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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EGP5</accession>
    <name>A0A8B7EGP5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AT-rich interactive domain-containing protein 4B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">180 kDa Sin3-associated polypeptide</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Histone deacetylase complex subunit SAP180</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARID4B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2. Interacts with ARID4A. Interacts with AR.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021274">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593712.1">
        <property type="nucleotide sequence ID" value="XM_012738258.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593713.1">
        <property type="nucleotide sequence ID" value="XM_012738259.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000043461.2">
        <property type="protein sequence ID" value="ENSMICP00000018469.2"/>
        <property type="gene ID" value="ENSMICG00000016358.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856481"/>
    <dbReference type="CTD" id="51742"/>
    <dbReference type="GeneTree" id="ENSGT00940000158149"/>
    <dbReference type="OrthoDB" id="10068428at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16883">
        <property type="entry name" value="ARID_ARID4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20460">
        <property type="entry name" value="Tudor_ARID4B_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20462">
        <property type="entry name" value="Tudor_ARID4B_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AT-rich interactive domain-containing protein 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000003">
        <property type="entry name" value="AT-rich interactive domain-containing protein 4B"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.30.140:FF:000009">
        <property type="entry name" value="AT-rich interactive domain-containing protein 4B"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.30.30.140:FF:000044">
        <property type="entry name" value="AT-rich interactive domain-containing protein 4B isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051232">
        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012603">
        <property type="entry name" value="ARID4A/B_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028853">
        <property type="entry name" value="ARID4B_ARID/BRIGHT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
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    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
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    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
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    <dbReference type="InterPro" id="IPR047476">
        <property type="entry name" value="Tudor_ARID4B_rpt1"/>
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    <dbReference type="InterPro" id="IPR047474">
        <property type="entry name" value="Tudor_ARID4B_rpt2"/>
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    <dbReference type="PANTHER" id="PTHR13964:SF24">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4B"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13964">
        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RBB1NT"/>
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        <property type="entry name" value="ARID"/>
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    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
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    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
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    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
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    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
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    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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            <dbReference type="ARBA" id="ARBA00053656"/>
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            <dbReference type="ARBA" id="ARBA00063472"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00083404"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS51011"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018469.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="1316" mass="147972" checksum="B388173EC27CCEC1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EP33</accession>
    <name>A0A8B7EP33_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Esterase OVCA2</fullName>
            <ecNumber evidence="5">3.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">OVCA2 serine hydrolase domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">OVCA2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of &gt;8 carbons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a carboxylic ester + H2O = an alcohol + a carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:33308"/>
            <dbReference type="EC" id="3.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03020371">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596120.1">
        <property type="nucleotide sequence ID" value="XM_012740666.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EP33"/>
    <dbReference type="Ensembl" id="ENSMICT00000070766.1">
        <property type="protein sequence ID" value="ENSMICP00000047051.1"/>
        <property type="gene ID" value="ENSMICG00000047371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105857925"/>
    <dbReference type="KEGG" id="mmur:105857925"/>
    <dbReference type="CTD" id="124641"/>
    <dbReference type="GeneTree" id="ENSGT00390000003541"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106435">
        <property type="term" value="F:carboxylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032526">
        <property type="term" value="P:response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000073">
        <property type="entry name" value="esterase OVCA2 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="10">
        <location>
            <begin position="5"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="227" mass="24119" checksum="8493F9F3252F5892" modified="2022-01-19" version="1">MAAKRPLRVLCLAGFRQSELGFREKTGALRKALRGRAELVCLSGPHPVPHAAGPEGAGPDSGPCPSEEQPRGWWFSEQDADVFSALEEPTVCRGLEEALGTVAQALNKLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFIILVSGFCPRGLGLKEPILQGPLSLPSLHVFGDTDRVIPSQESMQLASRFLGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ETF2</accession>
    <name>A0A8B7ETF2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Solute carrier family 12 member 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Electroneutral potassium-chloride cotransporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">K-Cl cotransporter 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Neuronal K-Cl cotransporter</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC12A5</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>K(+)(in) + chloride(in) = K(+)(out) + chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:72427"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598448.1">
        <property type="nucleotide sequence ID" value="XM_012742994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ETF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011379.3">
        <property type="protein sequence ID" value="ENSMICP00000010359.3"/>
        <property type="gene ID" value="ENSMICG00000011367.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859285"/>
    <dbReference type="KEGG" id="mmur:105859285"/>
    <dbReference type="CTD" id="57468"/>
    <dbReference type="GeneTree" id="ENSGT00940000160827"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060996">
        <property type="term" value="P:dendritic spine development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006971">
        <property type="term" value="P:hypotonic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030644">
        <property type="term" value="P:intracellular chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040040">
        <property type="term" value="P:thermosensory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000040">
        <property type="entry name" value="Solute carrier family 12 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000123">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000076">
        <property type="entry name" value="KCL_cotranspt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00930">
        <property type="entry name" value="2a30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF54">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12 MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SLC12"/>
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        <property type="entry name" value="KCLTRNSPORT"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="16" id="KW-0868">Chloride</keyword>
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        <location>
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        <location>
            <begin position="557"/>
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    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="581"/>
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        <location>
            <begin position="615"/>
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            <begin position="124"/>
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            <begin position="419"/>
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            <begin position="710"/>
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        <source>
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    <sequence length="1137" mass="125988" checksum="829B5BE68D83EAE1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F0F0</accession>
    <name>A0A8B7F0F0_MICMU</name>
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        <recommendedName>
            <fullName evidence="24">Serine/threonine-protein kinase STK11</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">STK11</name>
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    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Has a role in spermiogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012745790.3"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSMICP00000021105.1"/>
        <property type="gene ID" value="ENSMICG00000026794.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000062565.1">
        <property type="protein sequence ID" value="ENSMICP00000049787.1"/>
        <property type="gene ID" value="ENSMICG00000026794.2"/>
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    <dbReference type="GeneID" id="105860784"/>
    <dbReference type="KEGG" id="mmur:105860784"/>
    <dbReference type="CTD" id="6794"/>
    <dbReference type="GeneTree" id="ENSGT00940000158050"/>
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        <property type="component" value="Chromosome 24"/>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cilium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:intracellular protein-containing complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:serine/threonine protein kinase complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:LRR domain binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to UV-B"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:establishment of cell polarity"/>
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        <property type="term" value="P:G1 to G0 transition"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:glucose homeostasis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:Golgi localization"/>
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        <property type="term" value="P:intrinsic apoptotic signaling pathway by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="term" value="P:negative regulation of cell growth"/>
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    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of epithelial cell proliferation involved in prostate gland development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of axonogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030511">
        <property type="term" value="P:positive regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901610">
        <property type="term" value="P:positive regulation of vesicle transport along microtubule"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045059">
        <property type="term" value="P:positive thymic T cell selection"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein localization to nucleus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14119">
        <property type="entry name" value="STKc_LKB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000245">
        <property type="entry name" value="serine/threonine-protein kinase STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000235">
        <property type="entry name" value="serine/threonine-protein kinase STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039154">
        <property type="entry name" value="LKB1_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF94">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="16 25 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 25 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 26" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="28">
        <location>
            <begin position="49"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="27">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00059640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="437" mass="48932" checksum="167B36D6753AAE7F" modified="2022-01-19" version="1">MDVVDPQQLGVFTEGELMSVGMDTFIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPSPDTKDRWRSMTVVPYLEDLHGGDEDEDEDLFDIEDDIIYTQDFTVPGQVPEEEAGQNGQSRGLPKAVCMNGTESAQLSTKPKAECRAGASNPTRKACSASSKIRRLSACKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F9L3</accession>
    <name>A0A8B7F9L3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione hydrolase</fullName>
            <ecNumber evidence="5">2.3.2.2</ecNumber>
            <ecNumber evidence="5">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GGT1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="5"/>
    <dbReference type="EC" id="3.4.19.13" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03024698">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
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        <property type="nucleotide sequence ID" value="XM_012749275.2"/>
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        <property type="gene ID" value="ENSMICG00000027619.2"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
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    </dbReference>
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        <property type="term" value="P:peptide modification"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of immune system process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of inflammatory response"/>
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    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR055262">
        <property type="entry name" value="GGT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF56">
        <property type="entry name" value="GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00462">
        <property type="entry name" value="G_GLU_TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="399"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="451"/>
            <end position="452"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018741.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="569" mass="61366" checksum="A928552E8CB18FD4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FJ98</accession>
    <name>A0A8B7FJ98_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA m(6)A methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.348</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">METTL3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55584"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="2.1.1.348"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.348" evidence="1"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608105.1">
        <property type="nucleotide sequence ID" value="XM_012752651.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FJ98"/>
    <dbReference type="SMR" id="A0A8B7FJ98"/>
    <dbReference type="Ensembl" id="ENSMICT00000032459.2">
        <property type="protein sequence ID" value="ENSMICP00000032782.2"/>
        <property type="gene ID" value="ENSMICG00000015037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864667"/>
    <dbReference type="KEGG" id="mmur:105864667"/>
    <dbReference type="CTD" id="56339"/>
    <dbReference type="GeneTree" id="ENSGT00550000075058"/>
    <dbReference type="OrthoDB" id="10262526at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001734">
        <property type="term" value="F:mRNA m(6)A methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009048">
        <property type="term" value="P:dosage compensation by inactivation of X chromosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060339">
        <property type="term" value="P:negative regulation of type I interferon-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903679">
        <property type="term" value="P:positive regulation of cap-independent translational initiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MT-A70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12829:SF7">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51563">
        <property type="entry name" value="SAM_MTA70L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032782.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="580" mass="64468" checksum="42E4003C59B58E70" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FLT1</accession>
    <name>A0A8B7FLT1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenosine 3'-phospho 5'-phosphosulfate transporter 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC35B3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609136.1">
        <property type="nucleotide sequence ID" value="XM_012753682.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609137.1">
        <property type="nucleotide sequence ID" value="XM_012753683.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609138.1">
        <property type="nucleotide sequence ID" value="XM_012753684.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FLT1"/>
    <dbReference type="Ensembl" id="ENSMICT00000042328.2">
        <property type="protein sequence ID" value="ENSMICP00000039466.1"/>
        <property type="gene ID" value="ENSMICG00000012644.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865232"/>
    <dbReference type="CTD" id="51000"/>
    <dbReference type="GeneTree" id="ENSGT00940000157040"/>
    <dbReference type="OrthoDB" id="438495at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="369" mass="41091" checksum="4A879223E6808FD8" modified="2022-01-19" version="1">MDLKFNNSRKYISITVPSKTQTMSPHIKSIDDIVVLGINLSKFNKPTQFFICVAGVFIFYLIYGYLQELIFSVEGFKSYGWYLTLVQFAFYSIFGLIELQLIQDKRRRIPGKTYMIIAFLTVGTMGLSNTSLGYLNYPTQVIFKCCKLIPVMLGGVFIQGKRYNIVDVSAAVCMSLGLVWFTLADSTIAPNFNLTGVMLISLALCADAVIGNVQEKAMKLHNASNSEMVLYSYSIGFVYILLGLTCTSGVGPAVTFCSKNPFRTYGYAFLFSLTGYFGISFVLALIKIFGALLAVTVTTGRKAMTIVLSFIFFAKPFTFQYVWSGLLVVLGIFLNVYSKNMDKIRLPSLYALISKSVEARKSRTLAQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FQU6</accession>
    <name>A0A8B7FQU6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AMP deaminase</fullName>
            <ecNumber evidence="12">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AMPD3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">AMP deaminase plays a critical role in energy metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>AMP + H2O + H(+) = IMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:14777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.5.4.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:14778"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03006384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611274.1">
        <property type="nucleotide sequence ID" value="XM_012755820.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611275.1">
        <property type="nucleotide sequence ID" value="XM_012755821.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611278.1">
        <property type="nucleotide sequence ID" value="XM_012755824.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611279.1">
        <property type="nucleotide sequence ID" value="XM_012755825.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611280.1">
        <property type="nucleotide sequence ID" value="XM_012755826.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611281.1">
        <property type="nucleotide sequence ID" value="XM_012755827.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611282.1">
        <property type="nucleotide sequence ID" value="XM_012755828.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611284.1">
        <property type="nucleotide sequence ID" value="XM_012755830.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611285.1">
        <property type="nucleotide sequence ID" value="XM_012755831.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611286.1">
        <property type="nucleotide sequence ID" value="XM_012755832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FQU6"/>
    <dbReference type="Ensembl" id="ENSMICT00000065147.1">
        <property type="protein sequence ID" value="ENSMICP00000049058.1"/>
        <property type="gene ID" value="ENSMICG00000009437.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067389.1">
        <property type="protein sequence ID" value="ENSMICP00000040590.1"/>
        <property type="gene ID" value="ENSMICG00000009437.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866492"/>
    <dbReference type="CTD" id="272"/>
    <dbReference type="GeneTree" id="ENSGT00950000183011"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000171">
        <property type="entry name" value="AMP deaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF2">
        <property type="entry name" value="AMP DEAMINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001251">
        <property type="entry name" value="AMP_deaminase_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="767" mass="88798" checksum="683CEC47D7EF7425" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FZ49</accession>
    <name>A0A8B7FZ49_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RB-associated KRAB zinc finger protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RB-associated KRAB repressor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Zinc finger protein 769</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RBAK</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="function">
        <text evidence="15">May repress E2F-dependent transcription. May promote AR-dependent transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614837.1">
        <property type="nucleotide sequence ID" value="XM_012759383.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FZ49"/>
    <dbReference type="Ensembl" id="ENSMICT00000058426.1">
        <property type="protein sequence ID" value="ENSMICP00000048924.1"/>
        <property type="gene ID" value="ENSMICG00000044579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105868457"/>
    <dbReference type="KEGG" id="mmur:105868457"/>
    <dbReference type="CTD" id="57786"/>
    <dbReference type="GeneTree" id="ENSGT00940000154303"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000012">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000666">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001354">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002084">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000001">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000060">
        <property type="entry name" value="zinc finger protein 436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000290">
        <property type="entry name" value="Zinc finger protein 697 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001157">
        <property type="entry name" value="Zinc finger protein 793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF397">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="21">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="350"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="378"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="572"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="656"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="719" mass="83716" checksum="13892F52A61D6B64" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G1J9</accession>
    <name>A0A8B7G1J9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein C10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">C7H12orf57</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0456 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615873.1">
        <property type="nucleotide sequence ID" value="XM_012760419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G1J9"/>
    <dbReference type="Ensembl" id="ENSMICT00000064394.1">
        <property type="protein sequence ID" value="ENSMICP00000042045.1"/>
        <property type="gene ID" value="ENSMICG00000043340.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105868993"/>
    <dbReference type="CTD" id="105484214"/>
    <dbReference type="GeneTree" id="ENSGT00390000005242"/>
    <dbReference type="OrthoDB" id="75738at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026317">
        <property type="entry name" value="P_C10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13463:SF3">
        <property type="entry name" value="PROTEIN C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14974">
        <property type="entry name" value="P_C10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="126" mass="13194" checksum="426581446513FC0F" modified="2022-01-19" version="1">MTSASAQPAALSAEQAKVVLAEVIQAFSAPENAVRMDEARDNACNDMGKMLQFVLPVATQIQQEVIKAYGFSCDGEGVLKFARLVKSYEAQDPEIASLSGKLKALFLPPMTLPPHGPASGGSVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G3J5</accession>
    <name>A0A8B7G3J5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA repair protein XRCC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">X-ray repair cross-complementing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">XRCC1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity. Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Interacts with (poly-ADP-ribosylated) PARP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616694.1">
        <property type="nucleotide sequence ID" value="XM_012761240.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G3J5"/>
    <dbReference type="Ensembl" id="ENSMICT00000033569.2">
        <property type="protein sequence ID" value="ENSMICP00000028307.2"/>
        <property type="gene ID" value="ENSMICG00000014662.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869458"/>
    <dbReference type="CTD" id="7515"/>
    <dbReference type="GeneTree" id="ENSGT00390000004140"/>
    <dbReference type="OrthoDB" id="25840at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990599">
        <property type="term" value="F:3' overhang single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160002">
        <property type="term" value="F:ADP-D-ribose modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032356">
        <property type="term" value="F:oxidized DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072572">
        <property type="term" value="F:poly-ADP-D-ribose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905765">
        <property type="term" value="P:negative regulation of protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905051">
        <property type="term" value="P:regulation of base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033194">
        <property type="term" value="P:response to hydroperoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061819">
        <property type="term" value="P:telomeric DNA-containing double minutes formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17725">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17707">
        <property type="entry name" value="BRCT_XRCC1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000025">
        <property type="entry name" value="DNA repair protein XRCC1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000008">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000012">
        <property type="entry name" value="X-ray repair cross complementing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045080">
        <property type="entry name" value="BRCT_XRCC1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002706">
        <property type="entry name" value="Xrcc1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370:SF5">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11370">
        <property type="entry name" value="DNA-REPAIR PROTEIN XRCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01834">
        <property type="entry name" value="XRCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="16">
        <location>
            <begin position="538"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="226"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="400"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028307.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="633" mass="69374" checksum="B3C2A6CD820895A2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8H1</accession>
    <name>A0A8B7G8H1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proline synthase co-transcribed bacterial homolog protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PLPBP</name>
        <name evidence="2" type="synonym">PROSC</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023907">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618391.1">
        <property type="nucleotide sequence ID" value="XM_012762937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8H1"/>
    <dbReference type="Ensembl" id="ENSMICT00000064952.1">
        <property type="protein sequence ID" value="ENSMICP00000044252.1"/>
        <property type="gene ID" value="ENSMICG00000042505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870375"/>
    <dbReference type="KEGG" id="mmur:105870375"/>
    <dbReference type="CTD" id="11212"/>
    <dbReference type="GeneTree" id="ENSGT00390000004928"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="6">
        <location>
            <begin position="39"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="274" mass="30093" checksum="78F175C3A4475DC9" modified="2022-01-19" version="1">MWRAGSMSAELGVGFALRAVNERVQQAVARRPRDLPAIQPRLVAVSKTKPADMVIEAYNHGQRTFGENYVQELLEKASNPKILSSCPEIKWHFIGHLQKQNVNKLMAVPNLFMVETVDSTKLADKVNSSWQKKGSPERLKVMVQINTSGEESKHGLPPSEATAVVEHINAKCPSLEFVGLMTIGSFGHDPSQGPNPDFQVLLSLREALCAQLRIPTDQVELSMGMSMDFQHAIEVGSTNVRIGSTIFGERDYSKKPAPDKSAADLKAPAVAQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GB35</accession>
    <name>A0A8B7GB35_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PPP4C</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="7">Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits. Component of the PP4 complexes PPP4C-PPP4R1, PPP4C-PPP4R2, PPP4C-PPP4R2-PPP4R3A, PPP4C-PPP4R2-PPP4R3B and PPP4C-PPP4R4. The PPP4C-PPP4R2 complex appears to be a tetramer composed of 2 molecules of PPP4C and 2 molecules of PPP4R2. Interacts with REL, NFKB1/p50 and RELA. Interacts with SMN1 and GEMIN4. Interacts with IRS4 (phosphorylated). Interacts with SMEK1/PPP4R3A; the interaction requires PP4R2. Interacts with HDAC3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03021391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619769.1">
        <property type="nucleotide sequence ID" value="XM_012764315.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GB35"/>
    <dbReference type="SMR" id="A0A8B7GB35"/>
    <dbReference type="Ensembl" id="ENSMICT00000068545.1">
        <property type="protein sequence ID" value="ENSMICP00000040944.1"/>
        <property type="gene ID" value="ENSMICG00000009129.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871120"/>
    <dbReference type="KEGG" id="mmur:105871120"/>
    <dbReference type="CTD" id="5531"/>
    <dbReference type="GeneTree" id="ENSGT00930000151040"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000010">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="111"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="307" mass="35080" checksum="D6FE470A5C6CBCAC" modified="2022-01-19" version="1">MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GE88</accession>
    <name>A0A8B7GE88_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neurochondrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCDN</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neurochondrin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001646">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620719.1">
        <property type="nucleotide sequence ID" value="XM_012765265.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GE88"/>
    <dbReference type="Ensembl" id="ENSMICT00000048135.2">
        <property type="protein sequence ID" value="ENSMICP00000034870.1"/>
        <property type="gene ID" value="ENSMICG00000006440.3"/>
    </dbReference>
    <dbReference type="CTD" id="23154"/>
    <dbReference type="GeneTree" id="ENSGT00390000013601"/>
    <dbReference type="OrthoDB" id="8186546at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048168">
        <property type="term" value="P:regulation of neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008709">
        <property type="entry name" value="Neurochondrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13109:SF7">
        <property type="entry name" value="NEUROCHONDRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05536">
        <property type="entry name" value="Neurochondrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="712" mass="77182" checksum="9348A775A61F9392" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GN44</accession>
    <name>A0A8B7GN44_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Insulin like growth factor binding protein like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">IGFBPL1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03014697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624508.2">
        <property type="nucleotide sequence ID" value="XM_012769054.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144966.1">
        <property type="nucleotide sequence ID" value="XM_020289377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GN44"/>
    <dbReference type="Ensembl" id="ENSMICT00000068566.1">
        <property type="protein sequence ID" value="ENSMICP00000045465.1"/>
        <property type="gene ID" value="ENSMICG00000042294.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105873800"/>
    <dbReference type="CTD" id="347252"/>
    <dbReference type="GeneTree" id="ENSGT00530000063555"/>
    <dbReference type="OrthoDB" id="9535846at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071228">
        <property type="term" value="P:cellular response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000763">
        <property type="entry name" value="Insulin-like growth factor binding protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF16">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018239">
        <property type="entry name" value="IGFBP_rP_mac25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133906" evidence="7">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="151"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="274" mass="28681" checksum="1DC6830C9758164F" modified="2022-01-19" version="1">MPRLPLLFPLLLLLLPPLAPGLGLRGAGSRRPECGPCRPERCPAPASCPAPGISARDECGCCARCLGAERGGRPAGGGRALRPGLVCASRAAGAAPEGTGLCVCAQRGAVCGSDGRSYPSVCALRLRARHSPRAHLGHLHKARDGPCEFAPVVVIPPQSVHNVTGAQVCLSCEVRAVPTPVITWKKVTQSPGGTQVLEELPGDRVNMAVQVRGGPSDHEATAWILINPLRKEDEGVYQCHAANLVGEARSHGTVTVLELSKPKSPRFPAPDDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GSN3</accession>
    <name>A0A8B7GSN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">XK-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">XKR9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the XK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012876">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626239.1">
        <property type="nucleotide sequence ID" value="XM_012770785.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GSN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000013265.3">
        <property type="protein sequence ID" value="ENSMICP00000012096.3"/>
        <property type="gene ID" value="ENSMICG00000013281.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874691"/>
    <dbReference type="KEGG" id="mmur:105874691"/>
    <dbReference type="CTD" id="389668"/>
    <dbReference type="GeneTree" id="ENSGT01140000282565"/>
    <dbReference type="OrthoDB" id="8190653at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018629">
        <property type="entry name" value="XK-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050895">
        <property type="entry name" value="XK-related_scramblase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024">
        <property type="entry name" value="XK-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16024:SF13">
        <property type="entry name" value="XK-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09815">
        <property type="entry name" value="XK-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU910716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012096.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="373" mass="43483" checksum="DFFAC5599978AA5D" modified="2022-01-19" version="1">MKYTKHNFMMSVLGIIIYIIDLIVDIWVSVKFFLEGQYVFGILALSFMLFGTLVVQCFSYSWFKADLKKAGQESQRCLLLLHCLQGGVFTRYWFALKKGYGIAFKYNSKTNNFMEEEIDQHKEVIDRMTDLSMLRLFETYLEGGPQLILQLYILLEHGQANLSQYSAIAVSCCAISCSTVEYQIALRKSLPDKNLLNESGPKFIYLFYKLFTLISWMLSVVLLLFLNVKIALFLLLLLWFLGITWAFKKKTQFCTSISMEFLYRVVVGFILIFTFFNIKGQNTKRPMSYYYIVRVLSTLGILIVFWVFPLSIFSPDYFIPISITIVLTLLLGIIFLIVYYGTFHPTRSEETKCDEIDGKSVQRDCRVRYFLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GT11</accession>
    <name>A0A8B7GT11_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exosome component 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribosomal RNA-processing protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EXOSC7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Component of the RNA exosome core complex (Exo-9), composed of EXOSC1, EXOSC2, EXOSC3, EXOSC4, EXOSC5, EXOSC6, EXOSC7, EXOSC8 and EXOSC9; within the complex interacts with EXOSC2 and EXOSC4. The catalytically inactive RNA exosome core complex (Exo-9) associates with the catalytic subunit EXOSC10/RRP6. Exo-9 may associate with DIS3 to form the nucleolar exosome complex, or DIS3L to form the cytoplasmic exosome complex. Exo-9 is formed by a hexameric base ring consisting of the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and a cap ring consisting of EXOSC1, EXOSC2 and EXOSC3. The RNA exosome complex associates with cofactors C1D/RRP47, MPHOSPH6/MPP6 and MTREX/MTR4. Interacts with ZC3HAV1. Interacts with DIS3; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000337">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625798.1">
        <property type="nucleotide sequence ID" value="XM_012770344.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GT11"/>
    <dbReference type="Ensembl" id="ENSMICT00000073507.1">
        <property type="protein sequence ID" value="ENSMICP00000051350.1"/>
        <property type="gene ID" value="ENSMICG00000049103.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105874463"/>
    <dbReference type="KEGG" id="mmur:105874463"/>
    <dbReference type="CTD" id="23016"/>
    <dbReference type="GeneTree" id="ENSGT00950000183130"/>
    <dbReference type="OMA" id="YNTRIPK"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11367">
        <property type="entry name" value="RNase_PH_RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000009">
        <property type="entry name" value="Exosome complex component RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="13">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="14">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="291" mass="31864" checksum="EC8FDF0CC242FC37" modified="2022-01-19" version="1">MASVSLSEAEKVYIVHGVQEDLRVDGRGCEDYRCVEVETDVVSNTSGSARVKLGHTDILVGVKAEMGTPKLEKPNEGYLEFFVDCSANATPEFEGRGGDDLGTEIANTLYRIFNNKSSIDLKSLCISPREHCWVLYVDVLLLECGGNLFDAISVAVKAALFNTRIPRVRVLEDEEGSKDIELSDDPYDCIRLSVENVPCIVTLCKIGYRHVVDATLQEEACSLASLLVSVTSKGVVTCMRKVGKGSLDPESIFEMMETGKRVGKVLHTSLQSVLHKEESLGPKRQKVGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GZJ0</accession>
    <name>A0A8B7GZJ0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">RIO kinase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RIOK2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Associated with late 40S pre-ribosomal particles. Interacts with PLK1 (via its N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03016867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629144.1">
        <property type="nucleotide sequence ID" value="XM_012773690.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629151.1">
        <property type="nucleotide sequence ID" value="XM_012773697.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GZJ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000050767.2">
        <property type="protein sequence ID" value="ENSMICP00000039811.1"/>
        <property type="gene ID" value="ENSMICG00000037437.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069196.1">
        <property type="protein sequence ID" value="ENSMICP00000042197.1"/>
        <property type="gene ID" value="ENSMICG00000037437.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876083"/>
    <dbReference type="KEGG" id="mmur:105876083"/>
    <dbReference type="CTD" id="55781"/>
    <dbReference type="GeneTree" id="ENSGT00390000003255"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000208">
        <property type="term" value="P:positive regulation of ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030071">
        <property type="term" value="P:regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000307">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="22">
        <location>
            <begin position="66"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="552" mass="63613" checksum="B5B3AA54F036677F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HAM5</accession>
    <name>A0A8B7HAM5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3</fullName>
            <ecNumber evidence="18">7.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Cytochrome b ascorbate-dependent protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Lysosomal cytochrome b</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CYB561A3</name>
        <name evidence="26" type="synonym">LOC105878636</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30403"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="EC" id="7.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:30404"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="18"/>
    <dbReference type="EMBL" id="ABDC03005835">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633766.1">
        <property type="nucleotide sequence ID" value="XM_012778312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HAM5"/>
    <dbReference type="Ensembl" id="ENSMICT00000064372.1">
        <property type="protein sequence ID" value="ENSMICP00000044016.1"/>
        <property type="gene ID" value="ENSMICG00000013766.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878636"/>
    <dbReference type="KEGG" id="mmur:105878636"/>
    <dbReference type="GeneTree" id="ENSGT00950000183197"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF38">
        <property type="entry name" value="LYSOSOMAL MEMBRANE ASCORBATE-DEPENDENT FERRIREDUCTASE CYB561A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="25">
        <location>
            <begin position="68"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00042571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="298" mass="32956" checksum="EC1A5590D816202E" modified="2022-01-19" version="1">MLLSSEAAVSPGCRCPRVLHLPGASGAAARAQGGERRIPEALARCVLLWLGERLIRMASGWFYLSCLVLGSLGSMCILFTVYWMQFWCGGFAWDGSTHTFNWHPVLTVAGMVVFYGAGSLVYRLPQSWLGPKLPWKLLHAALHLMAFSLTVMGLVAVFKFHNHNHIANLYSLHSWLGITAVFLFACQWFLGFAIFLLPWASLWLRSLLKPIHVFFGASILSLSIASVISGINEKLFFVLKNATEPYSSLPSQAVFANSTGMLVVAFGLLVLYILLASSWKRPEPGMLTDRQPLLHDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HEN9</accession>
    <name>A0A8B7HEN9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase</fullName>
            <ecNumber evidence="14">2.4.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ST6GALNAC2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81643"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="Rhea" id="RHEA-COMP:19720"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="ChEBI" id="CHEBI:231970"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:81644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3-O-[N-acetyl-alpha-neuraminyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:81659"/>
            <dbReference type="Rhea" id="RHEA-COMP:14417"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:139598"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:81660"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a beta-D-galactosyl-(1-&gt;3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = a beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminyl-(2-&gt;6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11136"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:133470"/>
            <dbReference type="ChEBI" id="CHEBI:140764"/>
            <dbReference type="EC" id="2.4.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:11137"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.3" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03019865">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019866">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634357.1">
        <property type="nucleotide sequence ID" value="XM_012778903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HEN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000007521.3">
        <property type="protein sequence ID" value="ENSMICP00000006846.2"/>
        <property type="gene ID" value="ENSMICG00000007518.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878982"/>
    <dbReference type="KEGG" id="mmur:105878982"/>
    <dbReference type="CTD" id="10610"/>
    <dbReference type="GeneTree" id="ENSGT00940000160433"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000013">
        <property type="entry name" value="ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012163">
        <property type="entry name" value="Sialyl_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941:SF5">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45941">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005557">
        <property type="entry name" value="Sialyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134098" description="alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase" evidence="18">
        <location>
            <begin position="26"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="151"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006846.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="374" mass="41566" checksum="BE1E5DDC89977160" modified="2022-01-19" version="1">MGLPRSSLLCPVLLLAVACCGVLLALYSSAVQWDPEPGAGARETALSRAFLGLKASDSRTRKGRLCRHPLHLAVGRHRRFRRLFDFSSPVLLWGGLLTPELWDSLSQHRAPYGWQGLSRQVITSTLSLLNGSESAELFPLSGEPPPGCVRCAVVGNGGILNGSRQGANIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLISYGKLGFTSVPQGQDLRYIFIPSGIRDYVMLRSAILGVPVPEGRDEGDRPHTYFGPEASASKFKLLHPDFISYLTERFLKSKLINTNFGDLYMPSTGALMLLTALHTCDQVSAYGFITKNYQKFSDHYFEQKKKPLIFYSNHDLLLEATLWRDLHKAGVLQLYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HIZ0</accession>
    <name>A0A8B7HIZ0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Nostrin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nitric oxide synthase trafficker</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">eNOS-trafficking inducer</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NOSTRIN</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012781870.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000034756.1"/>
        <property type="gene ID" value="ENSMICG00000017323.3"/>
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    <dbReference type="GeneID" id="105880678"/>
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    <dbReference type="GeneTree" id="ENSGT00510000048120"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="SH3_Nostrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000186">
        <property type="entry name" value="Nitric oxide synthase trafficking"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000067">
        <property type="entry name" value="NOSTRIN isoform 1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
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        <property type="entry name" value="SH3 Domains"/>
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        <property type="entry name" value="FCH_dom"/>
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        <property type="entry name" value="HR1_rho-bd"/>
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    <keyword evidence="10 20 21" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
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            <begin position="292"/>
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        </location>
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        </source>
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            <dbReference type="ARBA" id="ARBA00022443"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00023212"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        </source>
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    <sequence length="507" mass="58120" checksum="2AAB847D603BE87D" modified="2022-01-19" version="1">MRDPLTDCPENKVYKNLKEFSQNGENFCKQITSVLQQRANLEISYAKGLQKLASKLSKTLQNTRKNCLSSAWAWASEGMKSAADLHQKLGKAIELEAIKPTYQVLNVQEKKRKSLDNEVEKTANLVISNWNQQIKAKKKLMVSTKKHEALFQLVESSKQSLNEKEKRKLLNKLKKSTEKLEKEDENYYQKNMAGYSTRLKWENTLENCYQNILELEKERIQLLCNNLNQYSQHISLFGQTLTTCHTQIHCAISKIDVEKDIQALMEETATLSTENKSEFLLTDYFEEDPNNTMDKDRRKTFIKPKLLRLQKDIEKASRDKEGLQRMLNTYSSNSSFSDTKSQKETAVLMDENNLKLDLLEANSYKLSSVLAELEQRPKPSHPCSTSIFKWKEKEHTHSYVKISRPSLMKRLDNVLSRASSDGQRTNLSSSSPASGATKSSNHLCKALYSFQARQDDELNLEKGDIVIIHEKKEEGWWFGSLNGRKGHFPAAYVEELPSNAGNTATQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HLX6</accession>
    <name>A0A8B7HLX6_MICMU</name>
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            <fullName evidence="2 13">Occludin</fullName>
        </recommendedName>
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        <name evidence="22" type="primary">OCLN</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with TJP1/ZO1. Interacts with VAPA. Interacts with CLDN1, CLDN6, CLDN9, CLDN11, CLDN12 and CLDN17. Interacts with PLSCR1. Interacts with LSR, ILDR1 and ILDR2. Interacts with TJP2/ZO2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cell junction</location>
            <location evidence="13">Tight junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 16">Belongs to the ELL/occludin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016064">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638596.1">
        <property type="nucleotide sequence ID" value="XM_012783142.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638604.1">
        <property type="nucleotide sequence ID" value="XM_012783150.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638615.1">
        <property type="nucleotide sequence ID" value="XM_012783161.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HLX6"/>
    <dbReference type="Ensembl" id="ENSMICT00000012690.3">
        <property type="protein sequence ID" value="ENSMICP00000011558.3"/>
        <property type="gene ID" value="ENSMICG00000012695.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881455"/>
    <dbReference type="KEGG" id="mmur:105881455"/>
    <dbReference type="CTD" id="100506658"/>
    <dbReference type="GeneTree" id="ENSGT00730000110989"/>
    <dbReference type="OrthoDB" id="8867927at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
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    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0796">Tight junction</keyword>
    <keyword evidence="6 13 15" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="67"/>
            <end position="89"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="140"/>
            <end position="161"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="195"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="244"/>
            <end position="265"/>
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        <location>
            <begin position="60"/>
            <end position="269"/>
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    </feature>
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        <location>
            <begin position="414"/>
            <end position="522"/>
        </location>
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        <location>
            <begin position="333"/>
            <end position="407"/>
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        <location>
            <begin position="436"/>
            <end position="487"/>
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        <location>
            <begin position="367"/>
            <end position="376"/>
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        <location>
            <begin position="381"/>
            <end position="390"/>
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            <begin position="391"/>
            <end position="400"/>
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        <location>
            <begin position="216"/>
            <end position="237"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00016772"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="522" mass="59357" checksum="87F1BCC6DD8AF32E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HM73</accession>
    <name>A0A8B7HM73_MICMU</name>
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        <recommendedName>
            <fullName evidence="15">Small ribosomal subunit protein mS27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">28S ribosomal protein S27, mitochondrial</fullName>
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        <alternativeName>
            <fullName evidence="16">Mitochondrial ribosomal protein S27</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MRPS27</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the mitochondrion-specific ribosomal protein mS27 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012783266.1"/>
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    <dbReference type="KEGG" id="mmur:105881562"/>
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    <dbReference type="GeneTree" id="ENSGT00390000007246"/>
    <dbReference type="OrthoDB" id="19830at2759"/>
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        <property type="component" value="Chromosome 12"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:tRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:mitochondrial translation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034913">
        <property type="entry name" value="mS27/PTCD2"/>
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    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019266">
        <property type="entry name" value="Ribosomal_mS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21393:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10037">
        <property type="entry name" value="MRP-S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="repeat" description="PPR" evidence="18">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039343.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="416" mass="47965" checksum="A1C4AC965F0424A9" modified="2022-01-19" version="1">MAAPMVWRGVLLVRKVILPQLSPAGKRCLLSAAYVDSHKWETREKEDYHLADLASLMDKTYERKLPVSSLTIGRFVDNISSREEVDHAEYYLYKFRHSPNCWYLREWTIHTWIRQCLKYGAQDKALYTLVNKVQYGVFLDNFTFNLLMDFFIKKEDYKSALSVVFEIMKQEAFEAPSTQLLSLYVLYHCLANKTDFSWEEERNFGASLLIPGLKQKNSVGLSSQLYGCALIGKVELQQGLRAVYHNMPLIWKPGYLDRALQVMEKVASSPEDVKLCKEALDVLDTVLKALTSPADDGASEAQPQEGEDNQASEEVVERLDFEETEQSKLPQYLERFKALHSKLQALDKVESESLLTLTTKLIKEKLPTHEAEDIATYEQKLQQWHVDQVSLIQREREYREKAKQEYLAQRAAEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRT9</accession>
    <name>A0A8B7HRT9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 169</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM169</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03010784">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640627.1">
        <property type="nucleotide sequence ID" value="XM_012785173.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640628.1">
        <property type="nucleotide sequence ID" value="XM_012785174.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640629.1">
        <property type="nucleotide sequence ID" value="XM_012785175.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640630.1">
        <property type="nucleotide sequence ID" value="XM_012785176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640631.1">
        <property type="nucleotide sequence ID" value="XM_012785177.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640632.1">
        <property type="nucleotide sequence ID" value="XM_012785178.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRT9"/>
    <dbReference type="Ensembl" id="ENSMICT00000061832.1">
        <property type="protein sequence ID" value="ENSMICP00000050174.1"/>
        <property type="gene ID" value="ENSMICG00000044265.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065662.1">
        <property type="protein sequence ID" value="ENSMICP00000043117.1"/>
        <property type="gene ID" value="ENSMICG00000044265.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882613"/>
    <dbReference type="KEGG" id="mmur:105882613"/>
    <dbReference type="CTD" id="92691"/>
    <dbReference type="GeneTree" id="ENSGT00390000015276"/>
    <dbReference type="OrthoDB" id="10066407at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029386">
        <property type="entry name" value="TMEM169"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31777">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31777:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15052">
        <property type="entry name" value="TMEM169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="297" mass="33410" checksum="B57C3A05D0B57E5C" modified="2022-01-19" version="1">MEEPAPVEGQTQLPSSYQGSLRKAVAAALALDGESTMGRRKKKKKESRPESIIVYRSDNEKTDEEPGELEGGEQPKEEEGDDFLDYPMDDGMWNMPLDSRYVTLTGTITRGKKKGQMVDIHVTLTEKELQELTKPKELSREATSEGREACQVGADRGPHVVLWTLVCLPVVFVLSFVVSFYYGTITWYNIFLVYNEERTFWHKISCCPCLILFYPVLIMAMASALGLYAAVVQLSWSWGAWWQAARDMEKGFCGWLCSKLGLEDCSPYSIVELLESDNISATLSNKDPTQEIETSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HUN8</accession>
    <name>A0A8B7HUN8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein NKG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Natural killer cell protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NKG7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases. Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection. Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules. Contributes to NK cell-mediated control of cancer metastasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytolytic granule membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PMP-22/EMP/MP20 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026408">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640995.1">
        <property type="nucleotide sequence ID" value="XM_012785541.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HUN8"/>
    <dbReference type="Ensembl" id="ENSMICT00000060930.1">
        <property type="protein sequence ID" value="ENSMICP00000047456.1"/>
        <property type="gene ID" value="ENSMICG00000046911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882857"/>
    <dbReference type="CTD" id="4818"/>
    <dbReference type="GeneTree" id="ENSGT01050000244814"/>
    <dbReference type="OrthoDB" id="9427654at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101004">
        <property type="term" value="C:cytolytic granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000033">
        <property type="entry name" value="Natural killer cell granule protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050579">
        <property type="entry name" value="PMP-22/EMP/MP20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671">
        <property type="entry name" value="EPITHELIAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10671:SF34">
        <property type="entry name" value="PROTEIN NKG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="165" mass="17513" checksum="87DF54E0D669FE93" modified="2022-01-19" version="1">MEPCRSLALLAGSLGLMSSLVALSTDFWFVAMGPTYSAHSGLWPREHGDSVAGYIHVTQSFCILAALWGLVSVGFLVLSCIPSLSAPGRGPLVATITAFAAALSMTVAMAVYTSERWGQPPHPQIQTFFSWSFYLGWVSAILLLCAGSLSLGAHCGTRQPGYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HY27</accession>
    <name>A0A8B7HY27_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane and coiled-coil domains 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMCO4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001949">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001951">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643133.1">
        <property type="nucleotide sequence ID" value="XM_012787679.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643134.1">
        <property type="nucleotide sequence ID" value="XM_012787680.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136740.1">
        <property type="nucleotide sequence ID" value="XM_020281151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HY27"/>
    <dbReference type="Ensembl" id="ENSMICT00000014263.3">
        <property type="protein sequence ID" value="ENSMICP00000013005.2"/>
        <property type="gene ID" value="ENSMICG00000014270.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884005"/>
    <dbReference type="KEGG" id="mmur:105884005"/>
    <dbReference type="CTD" id="255104"/>
    <dbReference type="GeneTree" id="ENSGT00390000001400"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="525"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013005.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="613" mass="65006" checksum="1EDBB7CF7775F749" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HZT3</accession>
    <name>A0A8B7HZT3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Ras-related protein Rab-24</fullName>
            <ecNumber evidence="8">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">RAB24</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="27">Interacts with ZFYVE20. Does not interact with the GDP dissociation inhibitors ARHGDIA and ARHGDIB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">Autophagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03033444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642781.1">
        <property type="nucleotide sequence ID" value="XM_012787327.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HZT3"/>
    <dbReference type="Ensembl" id="ENSMICT00000036244.2">
        <property type="protein sequence ID" value="ENSMICP00000029713.1"/>
        <property type="gene ID" value="ENSMICG00000036422.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105883849"/>
    <dbReference type="CTD" id="53917"/>
    <dbReference type="GeneTree" id="ENSGT00910000144316"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140013">
        <property type="term" value="P:meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001556">
        <property type="term" value="P:oocyte maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04118">
        <property type="entry name" value="Rab24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000799">
        <property type="entry name" value="ras-related protein Rab-24 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041828">
        <property type="entry name" value="Rab24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="23" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="20" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="18" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0636">Prenylation</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00093319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00093500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="203" mass="23070" checksum="549E0CD3C5F9449C" modified="2022-01-19" version="1">MSGQRVDVKVVMLGKEYVGKTSLVERYVHDRFLVGPYQNTIGAAFVAKVMSVGDQTVTLGIWDTAGSERYEAMSRIYYRGAKAAIVCYDLTDSSSFERAKFWVKELRSLEEGCQIYLCGTKSDLLEEDRRRRRVDFHDVQDYADNIKAQLFETSSKTGQSVDELFQKVAEDYVSVAAFQVMTEDKGVDLGQKANPYFYSCCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I0Q3</accession>
    <name>A0A8B7I0Q3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CUGBP Elav-like family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CELF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CELF/BRUNOL family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006156">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644143.1">
        <property type="nucleotide sequence ID" value="XM_012788689.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644148.1">
        <property type="nucleotide sequence ID" value="XM_012788694.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644154.1">
        <property type="nucleotide sequence ID" value="XM_012788700.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644215.1">
        <property type="nucleotide sequence ID" value="XM_012788761.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644220.1">
        <property type="nucleotide sequence ID" value="XM_012788766.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142070.1">
        <property type="nucleotide sequence ID" value="XM_020286481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I0Q3"/>
    <dbReference type="SMR" id="A0A8B7I0Q3"/>
    <dbReference type="Ensembl" id="ENSMICT00000063237.1">
        <property type="protein sequence ID" value="ENSMICP00000047958.1"/>
        <property type="gene ID" value="ENSMICG00000045113.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105884610"/>
    <dbReference type="KEGG" id="mmur:105884610"/>
    <dbReference type="CTD" id="10658"/>
    <dbReference type="GeneTree" id="ENSGT00940000158970"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001673">
        <property type="term" value="C:male germ cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106222">
        <property type="term" value="F:lncRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12631">
        <property type="entry name" value="RRM1_CELF1_2_Bruno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12634">
        <property type="entry name" value="RRM2_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12638">
        <property type="entry name" value="RRM3_CELF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000013">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000015">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000016">
        <property type="entry name" value="CUGBP Elav-like family member 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034196">
        <property type="entry name" value="CELF1/2_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034198">
        <property type="entry name" value="CELF1/2_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034199">
        <property type="entry name" value="CELF1/2_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="43"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="135"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="429"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="514" mass="55143" checksum="31E7DF974827F9B3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I483</accession>
    <name>A0A8B7I483_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LYR motif containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LYRM1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020982">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645614.1">
        <property type="nucleotide sequence ID" value="XM_012790160.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645615.1">
        <property type="nucleotide sequence ID" value="XM_012790161.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645616.1">
        <property type="nucleotide sequence ID" value="XM_012790162.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645617.1">
        <property type="nucleotide sequence ID" value="XM_012790163.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645618.1">
        <property type="nucleotide sequence ID" value="XM_012790164.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645619.1">
        <property type="nucleotide sequence ID" value="XM_012790165.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645620.1">
        <property type="nucleotide sequence ID" value="XM_012790166.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645621.1">
        <property type="nucleotide sequence ID" value="XM_012790167.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645622.1">
        <property type="nucleotide sequence ID" value="XM_012790168.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645624.1">
        <property type="nucleotide sequence ID" value="XM_012790170.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645625.1">
        <property type="nucleotide sequence ID" value="XM_012790171.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645626.1">
        <property type="nucleotide sequence ID" value="XM_012790172.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645627.1">
        <property type="nucleotide sequence ID" value="XM_012790173.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I483"/>
    <dbReference type="Ensembl" id="ENSMICT00000040087.2">
        <property type="protein sequence ID" value="ENSMICP00000019150.1"/>
        <property type="gene ID" value="ENSMICG00000036922.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885314"/>
    <dbReference type="KEGG" id="mmur:105885314"/>
    <dbReference type="CTD" id="57149"/>
    <dbReference type="GeneTree" id="ENSGT00390000006695"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20261">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045294">
        <property type="entry name" value="Complex1_LYR_LYRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040330">
        <property type="entry name" value="LYRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14273:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="122" mass="14221" checksum="28337F39EE93A8B3" modified="2022-01-19" version="1">MTTATRQEVLGLYRSIFRLARKWQAASGQMEDTIEEKQYILNEARTLFQKNKNLTDPELIKQCIDECTARIEIGLHYQIPYPRPIHLPPMGLTPLRGRGLRSQEKLRKLSKPVYLKSHDEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I792</accession>
    <name>A0A8B7I792_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="35 36">Serine/threonine-protein kinase mTOR</fullName>
            <ecNumber evidence="36">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="41" type="primary">MTOR</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:10597"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Lysosome membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Microsome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Mitochondrion outer membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">PML body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 36">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="36"/>
    <dbReference type="EMBL" id="ABDC03002388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646854.1">
        <property type="nucleotide sequence ID" value="XM_012791400.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000003888.3">
        <property type="protein sequence ID" value="ENSMICP00000003546.2"/>
        <property type="gene ID" value="ENSMICG00000003873.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105886039"/>
    <dbReference type="KEGG" id="mmur:105886039"/>
    <dbReference type="CTD" id="2475"/>
    <dbReference type="GeneTree" id="ENSGT00930000151037"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0007">Acetylation</keyword>
    <keyword evidence="22 36" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="31" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="26" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="18 36" id="KW-0418">Kinase</keyword>
    <keyword evidence="29" id="KW-0458">Lysosome</keyword>
    <keyword evidence="28" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-0492">Microsome</keyword>
    <keyword evidence="27" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="17 36" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="30" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 36" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="15 36" id="KW-0808">Transferase</keyword>
    <keyword evidence="23" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="FAT" evidence="39">
        <location>
            <begin position="1382"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="38">
        <location>
            <begin position="2156"/>
            <end position="2469"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="40">
        <location>
            <begin position="2517"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="37">
        <location>
            <begin position="1811"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="37">
        <location>
            <begin position="1836"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="37">
        <location>
            <begin position="1820"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="37">
        <location>
            <begin position="1836"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00051942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00073254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="40">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003546.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2549" mass="288861" checksum="FBFEC0623BBEE8A5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I965</accession>
    <name>A0A8B7I965_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc transporter SLC39A7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Solute carrier family 39 member 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Zrt-, Irt-like protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC39A7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Zn(2+)(in) = Zn(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29351"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">cis-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646820.1">
        <property type="nucleotide sequence ID" value="XM_012791366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I965"/>
    <dbReference type="Ensembl" id="ENSMICT00000000902.3">
        <property type="protein sequence ID" value="ENSMICP00000000813.2"/>
        <property type="gene ID" value="ENSMICG00000000905.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105886001"/>
    <dbReference type="KEGG" id="mmur:105886001"/>
    <dbReference type="CTD" id="7922"/>
    <dbReference type="GeneTree" id="ENSGT00940000160076"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110075">
        <property type="term" value="P:regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098773">
        <property type="term" value="P:skin epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950:SF25">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16950">
        <property type="entry name" value="ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0864">Zinc transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134266" description="Zinc transporter SLC39A7" evidence="14">
        <location>
            <begin position="33"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="243"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000813.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="469" mass="50057" checksum="7191EACF39A6DEE3" modified="2022-01-19" version="1">MARDLGAPHWVAVGLLTWAALGLLVAGHGGHGDPHEDLQEDFHGHSHRHSHEDFHHGHSHAQGHGHTHESIWHGHTHSHDHGHSHEDLHHGHSHGHSHERFYRGEHGHDHEHSHGGYGESGAPRIKQDLDTVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHHPLEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGLGHTHGHTHGSHGHERQECSSKEKQSSEEEEKEAGGLRKRRGGSTVPKDGPVRPQNPEELKTGSDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLLTAVGALAGTACALLTEGGAIGSEVAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVVMMVLIAHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XF72</accession>
    <name>A0A8B7XF72_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="8">MAD homolog</shortName>
            <shortName evidence="8">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SMAD9</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017777">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020146009.1">
        <property type="nucleotide sequence ID" value="XM_020290420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XF72"/>
    <dbReference type="Ensembl" id="ENSMICT00000070777.1">
        <property type="protein sequence ID" value="ENSMICP00000043807.1"/>
        <property type="gene ID" value="ENSMICG00000042342.1"/>
    </dbReference>
    <dbReference type="CTD" id="4093"/>
    <dbReference type="GeneTree" id="ENSGT00940000163092"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10490">
        <property type="entry name" value="MH1_SMAD_1_5_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000001">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF41">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03166">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00524">
        <property type="entry name" value="DWB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56366">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51075">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51076">
        <property type="entry name" value="MH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MH1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="MH2" evidence="10">
        <location>
            <begin position="236"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="430" mass="48596" checksum="08F5494F7473CD56" modified="2022-01-19" version="1">MHSTTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQPPCSALPPSPSHAFSQSPCTASYVHSPGSPLEPGSPYQHSDFRPVCYEEPQHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XGG9</accession>
    <name>A0A8B7XGG9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Collagen type VIII alpha 2 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COL8A2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_020290534.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000036439.2"/>
        <property type="gene ID" value="ENSMICG00000033642.2"/>
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        <property type="term" value="C:collagen trimer"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0048593">
        <property type="term" value="P:camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Complement C1q B chain"/>
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        <property type="entry name" value="Collagen/C1q_domain"/>
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        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
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        <property type="entry name" value="COLLAGEN TYPE VIII ALPHA 2 CHAIN"/>
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        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
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        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagen"/>
        <property type="match status" value="3"/>
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    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
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        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
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    <keyword evidence="4" id="KW-0176">Collagen</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135583" evidence="6">
        <location>
            <begin position="27"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="7">
        <location>
            <begin position="564"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
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            <begin position="73"/>
            <end position="91"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036439.2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJA3</accession>
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            <fullName evidence="4">4'-phosphopantetheine phosphatase</fullName>
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        <alternativeName>
            <fullName evidence="14">Inactive pantothenic acid kinase 4</fullName>
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        <name evidence="18" type="primary">PANK4</name>
        <name evidence="18" type="synonym">LOC105877375</name>
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    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-4'-phospho-S-sulfopantetheine + H2O = (R)-S-sulfopantetheine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:68340"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:177302"/>
            <dbReference type="ChEBI" id="CHEBI:177303"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:68341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with PKM.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJA3"/>
    <dbReference type="Ensembl" id="ENSMICT00000001013.3">
        <property type="protein sequence ID" value="ENSMICP00000000920.3"/>
        <property type="gene ID" value="ENSMICG00000001015.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158896"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000067">
        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pantothenate kinase 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1700.10">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.285.20">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035073">
        <property type="entry name" value="At2g17340_3_helix_bundle"/>
    </dbReference>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Type_II_PanK"/>
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    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-0944">Nitration</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="17">
        <location>
            <begin position="481"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="401"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000920.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="770" mass="85141" checksum="9C47BB4338EF853F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UPL2</accession>
    <name>A0A8C5UPL2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable ATP-dependent RNA helicase DDX52</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DDX52</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ABDC03019979">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019980">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UPL2"/>
    <dbReference type="Ensembl" id="ENSMICT00000004292.3">
        <property type="protein sequence ID" value="ENSMICP00000003913.3"/>
        <property type="gene ID" value="ENSMICG00000004290.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074863"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000906">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="196"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="378"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003913.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="555" mass="62913" checksum="13B4B8D2B8F434DB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UPN3</accession>
    <name>A0A8C5UPN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Interleukin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">IL26</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Immune regulatory cytokine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the IL-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009778">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637807.1">
        <property type="nucleotide sequence ID" value="XM_012782353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UPN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000003642.3">
        <property type="protein sequence ID" value="ENSMICP00000003316.2"/>
        <property type="gene ID" value="ENSMICG00000003647.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880943"/>
    <dbReference type="KEGG" id="mmur:105880943"/>
    <dbReference type="CTD" id="55801"/>
    <dbReference type="GeneTree" id="ENSGT00950000183124"/>
    <dbReference type="OrthoDB" id="9289879at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050680">
        <property type="term" value="P:negative regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020443">
        <property type="entry name" value="IL-10/19/20/24/26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48482">
        <property type="entry name" value="INTERLEUKIN-19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48482:SF1">
        <property type="entry name" value="INTERLEUKIN-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00726">
        <property type="entry name" value="IL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039435" description="Interleukin family protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003316.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="171" mass="20100" checksum="D6076872ECA51D5E" modified="2022-01-19" version="1">MLANCFLRSGLLFVTLSLAIAKHKQTSFTKSCYPRGILSQAVDTLYIKAAWLKATIPEDCIKNIRLLKKKTKKLFMKNCRFQEQLLSFFMEDVFGQLQLQVYKERHFVEDFHSLRQKLSCWISCDSSAREMKSITRMKRIFYKIGNKGIYKAISELDILLSWIKKFLESIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQG1</accession>
    <name>A0A8C5UQG1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BPI fold containing family B member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BPIFB6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021631">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQG1"/>
    <dbReference type="Ensembl" id="ENSMICT00000001985.3">
        <property type="protein sequence ID" value="ENSMICP00000001813.3"/>
        <property type="gene ID" value="ENSMICG00000001984.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00025">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051660">
        <property type="entry name" value="BPI_fold-BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019:SF2">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034404124" evidence="2">
        <location>
            <begin position="19"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="3">
        <location>
            <begin position="251"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001813.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="453" mass="48951" checksum="F801919A7AFA9870" modified="2022-01-19" version="1">MLRILCLALCSLLSGARADPGALLRLGMDVMNQVQSAMDESHILEKMAAEAGKKQPGMKPIKGITNLKVKDVQLPVITLNFVPGVGIFQCVATGMTITGKSFMGGNMEIIVVLNITATNRLLQDEETGLPTFKSEGCEVILVNVKTNLPSNMLPKVVNKFLDSTLHKVLPGLMCPAIDAVLVYVNRKWANLSDPMPVGQMGTVKYVLASTPATTASYIQVDFSPVVQQQKGKAIKLADAGAALQFPGGYAEGSSQLLVSAALLTAELALLRKSFNADIRETMIGELPPQTTVTLAGFIPAVAKAYPKSKPLVTQIRINKPPKLTMNPGKSLLHLHGTLKMSAAQQQGKGLASIFVLEAHFNLKVQYSVRENRLQMATTLDRLLSLARKSSSIGQFNEKELTGFITDYLQEAYIPVVNDALQVGLPLPDFLAMNYNLAQLDIVENALLLDLKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5URS4</accession>
    <name>A0A8C5URS4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5URS4"/>
    <dbReference type="Ensembl" id="ENSMICT00000002942.3">
        <property type="protein sequence ID" value="ENSMICP00000002679.3"/>
        <property type="gene ID" value="ENSMICG00000002937.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162785"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000144">
        <property type="entry name" value="sodium/hydrogen exchanger 11 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002679.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="420" mass="47957" checksum="19BCC634DA44939F" modified="2022-01-19" version="1">MRPDNLALIKFTVLIGYLRIIRFIPVLKTIIPMLIDITDVQIKKRLSLMYSITKGYVKSQEDAKLLIKQISSRESIYQKLYEILETNKREAIKELGLIEHEGRDVVIALKTKQAIRNVISKSLKNLTFLCSRGIIDKYEGIEMNKVLLTKIKALNNFPMAIPPPTPDKYLYNIIWLENKDVLIEFFKDRAKLAYFDYGDVICKEGEMPQGIYLIISGMAILHSLPPTFGIESSLMPARESKAMFTEYCTSGDIIGELSCLLKREIEYTVICETILEACFISLEDLYEGFDVFWPSLEYKIWLKFALSTAYQYFESSLIGEDLNFQKCVSLNRAYVETLSSCNEMTINNVTMKFVIIVYGSVIDTNTEEPYFAPCIIPKTCEQVQGTSDLSKLLIIQASEPSKNNNATNIMGKGLPFNKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UUH5</accession>
    <name>A0A8C5UUH5_MICMU</name>
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        <recommendedName>
            <fullName evidence="10">Nucleolar transcription factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Upstream-binding factor 1</fullName>
        </alternativeName>
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        <name evidence="15" type="primary">UBTF</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642154.1">
        <property type="nucleotide sequence ID" value="XM_012786700.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642155.1">
        <property type="nucleotide sequence ID" value="XM_012786701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UUH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000008118.3">
        <property type="protein sequence ID" value="ENSMICP00000007397.3"/>
        <property type="gene ID" value="ENSMICG00000008107.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000028818.2">
        <property type="protein sequence ID" value="ENSMICP00000031190.1"/>
        <property type="gene ID" value="ENSMICG00000008107.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883544"/>
    <dbReference type="CTD" id="7343"/>
    <dbReference type="GeneTree" id="ENSGT00940000161141"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21998">
        <property type="entry name" value="HMG-box_UBF1_rpt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22000">
        <property type="entry name" value="HMG-box_UBF1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22001">
        <property type="entry name" value="HMG-box_UBF1_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22002">
        <property type="entry name" value="HMG-box_UBF1_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22003">
        <property type="entry name" value="HMG-box_UBF1_rpt6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000021">
        <property type="entry name" value="nucleolar transcription factor 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000019">
        <property type="entry name" value="nucleolar transcription factor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000022">
        <property type="entry name" value="nucleolar transcription factor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000023">
        <property type="entry name" value="nucleolar transcription factor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000029">
        <property type="entry name" value="nucleolar transcription factor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029215">
        <property type="entry name" value="HMG_box_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051762">
        <property type="entry name" value="UBF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318:SF4">
        <property type="entry name" value="NUCLEOLAR TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46318">
        <property type="entry name" value="UPSTREAM BINDING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14887">
        <property type="entry name" value="HMG_box_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="261"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="14">
        <location>
            <begin position="531"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="112"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="261"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="370"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="531"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="509"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="611"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="627"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
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        </location>
    </feature>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080004"/>
        </source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007397.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="727" mass="84923" checksum="E7339A1B1BD38E12" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UUW4</accession>
    <name>A0A8C5UUW4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Potassium voltage-gated channel subfamily A member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Voltage-gated potassium channel subunit Kv1.2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">KCNA2</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Paranodal septate junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Lamellipodium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Synapse</location>
            <location evidence="23">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002913">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UUW4"/>
    <dbReference type="Ensembl" id="ENSMICT00000005271.3">
        <property type="protein sequence ID" value="ENSMICP00000004804.3"/>
        <property type="gene ID" value="ENSMICG00000035462.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158688"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043194">
        <property type="term" value="C:axon initial segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044224">
        <property type="term" value="C:juxtaparanode region of axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033010">
        <property type="term" value="C:paranodal junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021633">
        <property type="term" value="P:optic nerve structural organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045188">
        <property type="term" value="P:regulation of circadian sleep/wake cycle, non-REM sleep"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014059">
        <property type="term" value="P:regulation of dopamine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000025">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000007">
        <property type="entry name" value="Potassium voltage-gated channel subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003972">
        <property type="entry name" value="K_chnl_volt-dep_Kv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004049">
        <property type="entry name" value="K_chnl_volt-dep_Kv1.2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
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    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
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    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF23">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01509">
        <property type="entry name" value="KV12CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01496">
        <property type="entry name" value="SHAKERCHANEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="20" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0630">Potassium</keyword>
    <keyword evidence="12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="8" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="10" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="11 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="27">
        <location>
            <begin position="33"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004804.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="348" mass="39891" checksum="C9B8F1DF29166B71" modified="2022-01-19" version="1">MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILAASEHCTLGVNLAMGMTTQLTRASGLWIQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UV58</accession>
    <name>A0A8C5UV58_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Interleukin 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IL9</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03022451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UV58"/>
    <dbReference type="Ensembl" id="ENSMICT00000007280.3">
        <property type="protein sequence ID" value="ENSMICP00000006628.1"/>
        <property type="gene ID" value="ENSMICG00000007283.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015384"/>
    <dbReference type="OMA" id="IPSDNCP"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005140">
        <property type="term" value="F:interleukin-9 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016064">
        <property type="term" value="P:immunoglobulin mediated immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038113">
        <property type="term" value="P:interleukin-9-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032754">
        <property type="term" value="P:positive regulation of interleukin-5 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046425">
        <property type="term" value="P:regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020447">
        <property type="entry name" value="IL-9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16926">
        <property type="entry name" value="INTERLEUKIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16926:SF1">
        <property type="entry name" value="INTERLEUKIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01926">
        <property type="entry name" value="INTERLEUKIN9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034290706" evidence="1">
        <location>
            <begin position="19"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="144" mass="15792" checksum="CB996C0C5AA05B99" modified="2022-01-19" version="1">MLLAAVLASALLLCSVDGQRCSTLTGTLDVKFLIDKLQTDPPSRCNCSANVTSCLCLPIPSDDCDRPCFREGLSQLTNSTVQTRHPLVFSRVRKAVEVLKNSKCPFFSCEQPCNQTTAGNTLTFLTSLLEVFQKEKMRGMKGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVI5</accession>
    <name>A0A8C5UVI5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gastrokine-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Blottin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GKN2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605506.1">
        <property type="nucleotide sequence ID" value="XM_012750052.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVI5"/>
    <dbReference type="Ensembl" id="ENSMICT00000003743.3">
        <property type="protein sequence ID" value="ENSMICP00000003411.2"/>
        <property type="gene ID" value="ENSMICG00000003743.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863220"/>
    <dbReference type="KEGG" id="mmur:105863220"/>
    <dbReference type="CTD" id="200504"/>
    <dbReference type="GeneTree" id="ENSGT00930000150969"/>
    <dbReference type="OrthoDB" id="5977941at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002283">
        <property type="term" value="P:neutrophil activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044546">
        <property type="term" value="P:NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051414">
        <property type="term" value="P:response to cortisol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.150:FF:000004">
        <property type="entry name" value="Gastrokine 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051772">
        <property type="entry name" value="Gastrokine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16483">
        <property type="entry name" value="GASTROKINE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149921" description="Gastrokine-2" evidence="7">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="8">
        <location>
            <begin position="54"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00079996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003411.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="185" mass="20512" checksum="5A9BF360E6F0030C" modified="2022-01-19" version="1">MKILVAFLVVLAVFGIQSHGYEVFNIISPSSNGGNVQETVSIDNEKNVAIVNIHAGSCSSTTIFDYKHGYIASRVLSRRACFILKMNHKAIPALDTLQRYIYEKQALNNLYSNKYTWVKYNPVEALVTDMDWFLFGSPIKNLCEHIPLYKGEVVEKQRENTGAGGCAKVGLLGILGISLCADIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXG4</accession>
    <name>A0A8C5UXG4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Succinyl-CoA:glutarate CoA-transferase</fullName>
            <ecNumber evidence="14">2.8.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Dicarboxyl-CoA:dicarboxylic acid coenzyme A transferase SUGCT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Succinate--hydroxymethylglutarate CoA-transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SUGCT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Coenzyme A (CoA) transferase that reversibly catalyzes the transfer of a CoA moiety from a dicarboxyl-CoA to a dicarboxylate in a metabolite recycling process. Displays preference for succinyl-CoA and glutarate-CoA as dicarboxyl-CoA donors and glutarate, succinate, adipate/hexanedioate, itaconate and 3-hydroxy-3-methylglutarate as dicarboxylate acceptors. Acts on intermediates or end products of lysine and tryptophan degradation pathway, in particular catalyzes succinyl-CoA-dependent reesterification of free glutarate into glutaryl-CoA to prevent renal excretion of glutarate. Upon inflammation, may convert macrophage-derived itaconate to itaconyl-CoA in erythroid precursors where it negatively regulates the TCA cycle and heme synthesis to limit erythroid differentiation in the context of stress erythropoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81723"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:81724"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:81725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3-hydroxy-3-methylglutarate + succinyl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:12284"/>
            <dbReference type="ChEBI" id="CHEBI:17325"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.8.3.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12285"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:12286"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>glutarate + succinyl-CoA = glutaryl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:67900"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67901"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:67902"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81711"/>
            <dbReference type="ChEBI" id="CHEBI:17128"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:76327"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:81712"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:81713"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>itaconate + glutaryl-CoA = itaconyl-CoA + glutarate</text>
            <dbReference type="Rhea" id="RHEA:81715"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="ChEBI" id="CHEBI:30921"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:81716"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:81717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>itaconate + succinyl-CoA = itaconyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:38283"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57381"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:38284"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:38285"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CoA-transferase III family.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.13" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03015757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015758">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03015761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015762">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015763">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXG4"/>
    <dbReference type="Ensembl" id="ENSMICT00000010769.3">
        <property type="protein sequence ID" value="ENSMICP00000009815.2"/>
        <property type="gene ID" value="ENSMICG00000010769.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157866"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10540:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009815.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="445" mass="48522" checksum="207A186857097926" modified="2022-01-19" version="1">RLADRRAMLATLARVAALRRTGLLSCRGGGRGLWTSHPQSDMDHVKPLEGVKILDLTRVLAGPFATMNLGDLGAEVIKVERPGTGDDTRTWGPPFVGTESTYFLSVNRNKKSIAVNIKDPKGVKIIKELAAVCDVFVENYVPGKLSAMGLGYEDIDKIAPHIIYCSITGYGQTGPMSRRAGYDAVASAVSGLMHITGPEDGEPVRPGVAMTDLATGLYAYGAIMAGLIQRYKTGKGLFIDCNLLSSQVACLTQVAANYLTGQKEAKRWGTAHGSIVPYQAFKTKDGYLVVGAGNNEQFATVCKILNLPELIDDSKYKTNHLRVHNRKELIKILSARFEEELTSKWLYVFEGSGIPYGPINNMKNVFAEPQVLHNGLVMEMKHPTVGEISVPGPAVRYSKFKMSEARPPPLLGQHTTHILKEVLRYDDRAIGELLSSGVVTQHEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXQ9</accession>
    <name>A0A8C5UXQ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC6A9</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>glycine(out) + chloride(out) + 2 Na(+)(out) = glycine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70691"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXQ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000011036.3">
        <property type="protein sequence ID" value="ENSMICP00000010050.3"/>
        <property type="gene ID" value="ENSMICG00000011037.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157263"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005283">
        <property type="term" value="F:amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089718">
        <property type="term" value="P:amino acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11498">
        <property type="entry name" value="SLC6sbd_GlyT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003028">
        <property type="entry name" value="Na/ntran_symport_glycine_GLY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF263">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01204">
        <property type="entry name" value="GLY1TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0915">Sodium</keyword>
    <keyword evidence="7 14" id="KW-0769">Symport</keyword>
    <keyword evidence="5 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="450"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010050.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="658" mass="73436" checksum="91E0EB7F62A6A562" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZP1</accession>
    <name>A0A8C5UZP1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Smoothelin like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SMTNL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the smoothelin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020427">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634636.1">
        <property type="nucleotide sequence ID" value="XM_012779182.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZP1"/>
    <dbReference type="Ensembl" id="ENSMICT00000012426.3">
        <property type="protein sequence ID" value="ENSMICP00000011316.2"/>
        <property type="gene ID" value="ENSMICG00000012429.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879150"/>
    <dbReference type="KEGG" id="mmur:105879150"/>
    <dbReference type="CTD" id="342527"/>
    <dbReference type="GeneTree" id="ENSGT00940000154495"/>
    <dbReference type="OrthoDB" id="21607at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="CDD" id="cd21261">
        <property type="entry name" value="CH_SMTNL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000009">
        <property type="entry name" value="smoothelin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF37">
        <property type="entry name" value="SMOOTHELIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="347"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="87"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011316.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="457" mass="49457" checksum="57E279DF69BD04D9" modified="2022-01-19" version="1">MEPAPDAEEARSVREALGRYEAALEGAVRALHEDMQGLQRGVERRVAEALRLAGPLARTVAELQRDNQRLQAQLERLTRQVEALGLASGLSPAPGTPSPPPAPGVPDRAPRLGTARFASHATFSLSGRGQSVDHDEASELEMRRTSNSCVIENGHQPGAGPGDGPPEAAPTFPAPEPPKPRPVSLSLRLPHQPVTAVTRVSERFSGETSAAALSPTSAAILGGLTPSPSEAPTPWTPSPSEKNPPFPRSLSSSGFGAVAASKRSDSPPLVTPPQSPASPQPPATTQVHRPGERRRELVRSQTLPRTSGAQARKALFEKWEQDTGGKGRGEARAKLKRSQSFGVASASSIKQILLEWCRSKTLGYQHVDLQNFSSSWSDGMAFCALVHSFFPDAFDYNSLSPTQRQKNFELAFTMAENLANCERLIEVEDMMVMGRRPDPMCVFTYVQSLYNHLRRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZV4</accession>
    <name>A0A8C5UZV4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Eukaryotic translation initiation factor 2-alpha kinase 1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Hemin-sensitive initiation factor 2-alpha kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">EIF2AK1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Synthesized in an inactive form that binds to the N-terminal domain of CDC37. Has to be associated with a multiprotein complex containing Hsp90, CDC37 and PPP5C for maturation and activation by autophosphorylation. The phosphatase PPP5C modulates this activation. Homodimer; homodimerizes in presence of heme, forming a disulfide-linked inactive homodimer. Interacts with DELE1; binds both to full-length DELE1 and processed form of DELE1 (S-DELE1) in response to stress, leading to activate its protein kinase activity and trigger the integrated stress response (ISR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ABDC03021051">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZV4"/>
    <dbReference type="Ensembl" id="ENSMICT00000012840.3">
        <property type="protein sequence ID" value="ENSMICP00000011698.3"/>
        <property type="gene ID" value="ENSMICG00000012815.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157605"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002526">
        <property type="term" value="P:acute inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment of localization in cell"/>
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        <property type="term" value="P:HRI-mediated signaling"/>
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    </dbReference>
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        <property type="term" value="P:macrophage differentiation"/>
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    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of hemoglobin biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phagocytosis"/>
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        <property type="term" value="P:protein localization to mitochondrion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protoporphyrinogen IX metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to iron ion starvation"/>
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        <property type="term" value="P:translational initiation"/>
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        <property type="entry name" value="STKc_EIF2AK1_HRI"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 alpha kinase 1"/>
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        <property type="entry name" value="Putative eukaryotic translation initiation factor 2-alpha kinase 1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
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        <property type="entry name" value="HRI2_3H"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22949">
        <property type="entry name" value="HRI2_3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="167"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="20">
        <location>
            <begin position="590"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040433"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00042456"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00042914"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046654"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011698.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="630" mass="71287" checksum="4165542F87F5FE2B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V092</accession>
    <name>A0A8C5V092_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Transient receptor potential cation channel subfamily V member 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Calcium transport protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Epithelial calcium channel 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">TRPV6</name>
        <name evidence="28" type="synonym">TRPV5</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV6 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V092"/>
    <dbReference type="Ensembl" id="ENSMICT00000007382.3">
        <property type="protein sequence ID" value="ENSMICP00000006717.3"/>
        <property type="gene ID" value="ENSMICG00000007378.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156687"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034704">
        <property type="term" value="C:calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035898">
        <property type="term" value="P:parathyroid hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22192">
        <property type="entry name" value="TRPV5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000143">
        <property type="entry name" value="transient receptor potential cation channel subfamily V member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000230">
        <property type="entry name" value="transient receptor potential cation channel subfamily V member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008344">
        <property type="entry name" value="TRPV5/TRPV6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008345">
        <property type="entry name" value="TrpV6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF25">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
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        <property type="entry name" value="ECACCHANNEL"/>
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    <dbReference type="PRINTS" id="PR01766">
        <property type="entry name" value="ECACCHANNEL1"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 24" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="11" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="24">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="27">
        <location>
            <begin position="435"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="696"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="699"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="712"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054373"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060957"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00068288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075384"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006717.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="765" mass="86857" checksum="725C9FBA9989B1B7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V0N7</accession>
    <name>A0A8C5V0N7_MICMU</name>
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        <recommendedName>
            <fullName evidence="9">chymotrypsin</fullName>
            <ecNumber evidence="9">3.4.21.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CTRB1</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.21.1" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03024134">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V0N7"/>
    <dbReference type="Ensembl" id="ENSMICT00000013546.3">
        <property type="protein sequence ID" value="ENSMICP00000012357.3"/>
        <property type="gene ID" value="ENSMICG00000013553.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153216"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007586">
        <property type="term" value="P:digestion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000118">
        <property type="entry name" value="Chymotrypsinogen A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000176">
        <property type="entry name" value="Chymotrypsinogen A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250">
        <property type="entry name" value="CHYMOTRYPSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24250:SF65">
        <property type="entry name" value="CHYMOTRYPSINOGEN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0222">Digestion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034755074" description="chymotrypsin" evidence="11">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="12">
        <location>
            <begin position="34"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012357.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="263" mass="27827" checksum="D76B4D4EFC022539" modified="2022-01-19" version="1">MACLWLLSCWALLGTAFGCGVPAINPVLTGLSRIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVKTTDQVVAGEFDQGSDEENIQVLKIAKVFKNPKFNMLTVRNDITLLKLATPARFSDTVSPVCLPSADDDFPAGSLCVTTGWGKTKYNANKTPDKLQQAALPLMSNADCKKFWGSKITDVMVCAGASGVSSCMGDSGGPLVCQKDGAWNLVGIVSWGSGTCSTSSPGVYARVTELLPWVEEILAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V200</accession>
    <name>A0A8C5V200_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EPHX3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613833.1">
        <property type="nucleotide sequence ID" value="XM_012758379.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V200"/>
    <dbReference type="Ensembl" id="ENSMICT00000014245.3">
        <property type="protein sequence ID" value="ENSMICP00000012987.2"/>
        <property type="gene ID" value="ENSMICG00000014256.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867940"/>
    <dbReference type="KEGG" id="mmur:105867940"/>
    <dbReference type="CTD" id="79852"/>
    <dbReference type="GeneTree" id="ENSGT00940000162086"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="98"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012987.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="360" mass="40799" checksum="E0E0BD31BA2ED18E" modified="2022-01-19" version="1">MPDLVVTALLAPSRLSLKLLRAFLWSLVFSAALVAAAAYGCVALAHVLCRPRRGCCGRRRRAAPACLSDPSLGEHAFLTLKSSGLRLHYVSAGRGNGPLMLFLHGFPENWFSWRYQLREFQSRFHVVAVDLRGYGPSDAPRDVDCYTTSLLMADIEDVILGLGYSKCILVSHDWGALIAWNFSIYYPSMVERMVVVSGPPMSVYQDYCLRHIGQLFRSNYMFLFQLPWLPEKFLSMSDFQILKTTLAHRKSGIPHLTPSELEAFLYNFSQPNGLTGPINYYRNLFRNFPLEPQELAAPTLLLWGEKDQYFELGLVAAIGSRFVPGRLEAHILPGAGHWIPQSHPREMHQYMWAFLQDLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2J1</accession>
    <name>A0A8C5V2J1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-defensin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DEFB121</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Has antibacterial activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta-defensin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021647">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020137385.1">
        <property type="nucleotide sequence ID" value="XM_020281796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2J1"/>
    <dbReference type="Ensembl" id="ENSMICT00000014637.3">
        <property type="protein sequence ID" value="ENSMICP00000013343.1"/>
        <property type="gene ID" value="ENSMICG00000014655.3"/>
    </dbReference>
    <dbReference type="GeneID" id="109729666"/>
    <dbReference type="KEGG" id="mmur:109729666"/>
    <dbReference type="CTD" id="245934"/>
    <dbReference type="GeneTree" id="ENSGT00730000111628"/>
    <dbReference type="OMA" id="TPAMKCW"/>
    <dbReference type="OrthoDB" id="9534975at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.360.10">
        <property type="entry name" value="Antimicrobial Peptide, Beta-defensin 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050544">
        <property type="entry name" value="Beta-defensin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025933">
        <property type="entry name" value="Beta_defensin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15001:SF8">
        <property type="entry name" value="BETA-DEFENSIN 121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15001">
        <property type="entry name" value="BETA-DEFENSIN 123-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13841">
        <property type="entry name" value="Defensin_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0044">Antibiotic</keyword>
    <keyword evidence="4 9" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6 9" id="KW-0211">Defensin</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039452" description="Beta-defensin" evidence="9">
        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-defensin" evidence="10">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU231113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="76" mass="8444" checksum="CCFA54DBC4931490" modified="2022-01-19" version="1">MKLLLLVLIVTLLPVQVTPVKKCWSKLGRCRTTCKQSEVFYILCQTEFKCCVESKNVPVKPELPNTDGSLTSSSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2T2</accession>
    <name>A0A8C5V2T2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 138</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCDC138</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593074.1">
        <property type="nucleotide sequence ID" value="XM_012737620.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2T2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011890.3">
        <property type="protein sequence ID" value="ENSMICP00000010828.2"/>
        <property type="gene ID" value="ENSMICG00000011882.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856130"/>
    <dbReference type="CTD" id="165055"/>
    <dbReference type="GeneTree" id="ENSGT00390000000217"/>
    <dbReference type="OrthoDB" id="2161164at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038798">
        <property type="entry name" value="CCDC138"/>
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    <dbReference type="InterPro" id="IPR048750">
        <property type="entry name" value="CCDC138_C"/>
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    <dbReference type="InterPro" id="IPR048751">
        <property type="entry name" value="CCDC138_CC"/>
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    <dbReference type="PANTHER" id="PTHR34523">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34523:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 138"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CCDC138_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CCDC138_cc"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="265"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Coiled-coil" evidence="3">
        <location>
            <begin position="364"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010828.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="666" mass="76421" checksum="A15ECB34D114EBD2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V410</accession>
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        <submittedName>
            <fullName evidence="7">Integrator complex subunit 8</fullName>
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        <name evidence="7" type="primary">INTS8</name>
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    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Integrator subunit 8 family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013204">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013206">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V410"/>
    <dbReference type="Ensembl" id="ENSMICT00000015580.3">
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        <property type="gene ID" value="ENSMICG00000015571.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007597"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR057980">
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13350:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25756">
        <property type="entry name" value="TPR_INTS8"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="INTS8 TPR repeats" evidence="6">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007147"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Coiled-coil domain containing 33</fullName>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
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            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V8A7"/>
    <dbReference type="Ensembl" id="ENSMICT00000036635.2">
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        <property type="gene ID" value="ENSMICG00000036163.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017366"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039889">
        <property type="entry name" value="CCD33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21623">
        <property type="entry name" value="SPERIOLIN-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="431"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="648"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017726.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="747" mass="83675" checksum="882C50DE2E5A9F63" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBK1</accession>
    <name>A0A8C5VBK1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PMS1 homolog 2, mismatch repair system component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PMS2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of PMS2 and MLH1 (MutL alpha); this interaction is required for the stability of both partners. Forms a ternary complex with MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3). Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBS1 protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Interacts with MTMR15/FAN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021051">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBK1"/>
    <dbReference type="Ensembl" id="ENSMICT00000032925.2">
        <property type="protein sequence ID" value="ENSMICP00000017811.2"/>
        <property type="gene ID" value="ENSMICG00000012794.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155381"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016446">
        <property type="term" value="P:somatic hypermutation of immunoglobulin genes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.20:FF:000019">
        <property type="entry name" value="PMS1 homolog 2, mismatch repair system component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="277"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00063589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017811.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="455" mass="50802" checksum="423066B53D7B4F55" modified="2022-01-19" version="1">MERAEGSSTELAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSVDAGATNIDLRLKDYGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVSISTCHKSAKVGTRLVFDHNGKIIQKTPYPRPRGTTVSVQQLFYTLPVRHKEFQRNIKKEYARMVQVLHAYCIISAGIRISCTNQLGQGKRQSVVCTGGSSSIKENIGSVFGQKQLQSLIPFVQLPPSDSVCEEYGLSCSDALHNLFYKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQGQRLIAPQTLNLTAVNEAILIENLEIFRKNGFDFPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMCRPSRVRQMFASRACRKSVMIGTALNTSEMKKLIAHMGEMDHPWNCPHGRPTMRHIANLDVISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDZ8</accession>
    <name>A0A8C5VDZ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">N-alpha-acetyltransferase 30</fullName>
            <ecNumber evidence="15">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">N-acetyltransferase 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22 24" type="primary">NAA30</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. N-terminal acetylation protects proteins from ubiquitination and degradation by the N-end rule pathway. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03004079">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641070.1">
        <property type="nucleotide sequence ID" value="XM_012785616.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDZ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000046442.2">
        <property type="protein sequence ID" value="ENSMICP00000020794.1"/>
        <property type="gene ID" value="ENSMICG00000030737.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105882901"/>
    <dbReference type="KEGG" id="mmur:105882901"/>
    <dbReference type="CTD" id="122830"/>
    <dbReference type="GeneTree" id="ENSGT00390000005665"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="21">
        <location>
            <begin position="212"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="101"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00079214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="RefSeq" id="XP_012641070.1"/>
        </source>
    </evidence>
    <sequence length="360" mass="39009" checksum="080BF5D42F015EAA" modified="2022-01-19" version="1">MAEVPPGPSSLLPPPAPPAPAAAEPRCPFPVGAALACCSEDEEDDEEHEGGGGRSPAGGQPTAAAKGHTCLRCPQPSQEQQQLNGLISPELRHLRAAASLKSKVLSAAEAAATTATPDGGPRATATKGAGVHSGERPSHSLPNNARTAVPSPAEAAAASDPAAARNGLDEGTEQEEEEDEQVRLLSSSLTAGCSLRSLSGREVEPGEDRTIRYVRYESELQMPDIMRLITKDLSEPYSIYTYRYFIHNWPQLCFLAMVGEECVGAIVCKLDMHKKMFRRGYIAMLAVDSKYRRNGIGTNLVKKAIYAMVEGDCDEVVLETEITNKSALKLYENLGFVRDKRLFRYYLNGVDALRLKLWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VE92</accession>
    <name>A0A8C5VE92_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Tyrosine-protein kinase receptor</fullName>
            <ecNumber evidence="28">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">NTRK3</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220. Interacts with PTPRS. Interacts with MAPK8IP3/JIP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="28">Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="28"/>
    <dbReference type="EMBL" id="ABDC03013673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013674">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013675">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013676">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013677">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013678">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VE92"/>
    <dbReference type="Ensembl" id="ENSMICT00000041915.2">
        <property type="protein sequence ID" value="ENSMICP00000020945.2"/>
        <property type="gene ID" value="ENSMICG00000004359.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155645"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043121">
        <property type="term" value="F:neurotrophin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005030">
        <property type="term" value="F:neurotrophin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
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        <property type="entry name" value="Tyr_kinase_rcpt_2_CS"/>
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        <property type="entry name" value="NT-3 GROWTH FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LRR_8"/>
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        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NTKRECEPTOR"/>
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        <property type="entry name" value="NTKRECEPTOR3"/>
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        <property type="entry name" value="TYRKINASE"/>
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        <property type="entry name" value="LRRCT"/>
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        <property type="entry name" value="TyrKc"/>
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    <keyword evidence="9 25 27" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="7 30" id="KW-0732">Signal</keyword>
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    <keyword evidence="6 28 29" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="32"/>
            <end position="825"/>
        </location>
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        <location>
            <begin position="430"/>
            <end position="453"/>
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    </feature>
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        <location>
            <begin position="210"/>
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        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="31">
        <location>
            <begin position="538"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="544"/>
            <end position="552"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25 27">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with SHC1" evidence="26">
        <location>
            <position position="516"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with PLCG1" evidence="26">
        <location>
            <position position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047078"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00055541"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-51"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR620777-52"/>
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    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000312"/>
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    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000256" key="30">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="825" mass="92726" checksum="92C7A82E4F3E6510" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEW8</accession>
    <name>A0A8C5VEW8_MICMU</name>
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        <recommendedName>
            <fullName evidence="11">F-box/LRR-repeat protein 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">F-box and leucine-rich repeat protein 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">FBXL19</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization. Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner. Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration. Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis. Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Directly interacts with SKP1 and CUL1. Interacts with RNF20.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000018373.1"/>
        <property type="gene ID" value="ENSMICG00000001566.3"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="term" value="F:unmethylated CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="F-box_JHDM"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd15645">
        <property type="entry name" value="PHD_FXL19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box/LRR-repeat protein 19 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000020">
        <property type="entry name" value="lysine-specific demethylase 2B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CXXC-type" evidence="16">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="15">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="130"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="674" mass="73776" checksum="E5F3AB8578948CBC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEY0</accession>
    <name>A0A8C5VEY0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Endosome-lysosome associated apoptosis and autophagy regulator family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ELAPOR2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELAPOR family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015441">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ENSMICG00000013590.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879359"/>
    <dbReference type="KEGG" id="mmur:105879359"/>
    <dbReference type="CTD" id="222223"/>
    <dbReference type="GeneTree" id="ENSGT00940000154983"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030513">
        <property type="term" value="P:positive regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056609">
        <property type="entry name" value="Elapor1-like_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056606">
        <property type="entry name" value="Elapor1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056608">
        <property type="entry name" value="Elapor1/2_GBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056607">
        <property type="entry name" value="Elapor1/2_MRH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056610">
        <property type="entry name" value="Elapor1/2_TNFR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF3">
        <property type="entry name" value="ENDOSOME_LYSOSOME-ASSOCIATED APOPTOSIS AND AUTOPHAGY REGULATOR FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23089">
        <property type="entry name" value="ELAPOR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23031">
        <property type="entry name" value="GBD_ELAPOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23032">
        <property type="entry name" value="GBD_ELAPOR1-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23087">
        <property type="entry name" value="MRH_ELAPOR1_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23091">
        <property type="entry name" value="TNFR_ELAPOR1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="672"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1029" mass="113532" checksum="6B08DC294044B36A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHF8</accession>
    <name>A0A8C5VHF8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Microtubule actin crosslinking factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">MACF1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
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            <location evidence="3">Cell projection</location>
            <location evidence="3">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001700">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="TreeGrafter"/>
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    <sequence length="7589" mass="861078" checksum="1F787851741CE41B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHY9</accession>
    <name>A0A8C5VHY9_MICMU</name>
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        <recommendedName>
            <fullName evidence="11">ADP-ribosylation factor-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ARL3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03019375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03019376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012770176.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VHY9"/>
    <dbReference type="Ensembl" id="ENSMICT00000047491.2">
        <property type="protein sequence ID" value="ENSMICP00000023306.1"/>
        <property type="gene ID" value="ENSMICG00000012249.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874371"/>
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        <property type="component" value="Chromosome 15"/>
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    <keyword evidence="6 12 14" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="24"/>
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        <ligand>
            <name>GTP</name>
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            <position position="48"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJ44</accession>
    <name>A0A8C5VJ44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like DNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MSANTD1</name>
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    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJ44"/>
    <dbReference type="Ensembl" id="ENSMICT00000046561.2">
        <property type="protein sequence ID" value="ENSMICP00000023440.2"/>
        <property type="gene ID" value="ENSMICG00000031701.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002245"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
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        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000135">
        <property type="entry name" value="Myb/SANT-like DNA-binding domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026095">
        <property type="entry name" value="Myb/SANT-like_DNA-bd_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22666:SF3">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="3">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00070622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023440.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="265" mass="30572" checksum="9FB784351963A83C" modified="2022-01-19" version="1">PGPRLSASSMAAAEVPGYLVSPQTEKHRRARNWTDAEMRGLMLVWEEFFDELKQTKRNAKVYEKMASKLFEMTGERRLGEEIKIKITNMTFQYRKLKCMTDSESVPPDWPYYLAIDRILAKVPESCDGKLPDGQQPGPSTSQTEASLSPPAKSTPLYFPYNQCSYEGRFEDDHSDSSSSLLSLKFRSEERPVKKRKVQSGHLQKKKLRLLEAMLEEQRRLSRAVEETCREARRVLDQQHVLQVQSLQLQERMMNLLEKIIAKSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VR82</accession>
    <name>A0A8C5VR82_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat containing 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LRRC28</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03013599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013600">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619994.1">
        <property type="nucleotide sequence ID" value="XM_012764540.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VR82"/>
    <dbReference type="Ensembl" id="ENSMICT00000040220.2">
        <property type="protein sequence ID" value="ENSMICP00000026199.1"/>
        <property type="gene ID" value="ENSMICG00000028987.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871272"/>
    <dbReference type="KEGG" id="mmur:105871272"/>
    <dbReference type="CTD" id="123355"/>
    <dbReference type="GeneTree" id="ENSGT00940000157771"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF12">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="101"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="367" mass="41768" checksum="90F3C0E14E2F9109" modified="2022-01-19" version="1">MASELCKTISVARLEKHKNLFLNYRNLHHFPLELLKDEGLQYLERLYMKRNSLTTLPENLAQKLPNLVELYLHSNNIVVVPEAIGSLVKLQCLDLSDNALEIVCPEIGRLRALRHLRLANNQLQFLPPEVGDLKELQTLDISTNRLLTLPERLHLCLSLQYLTVDRNRLWCVPRHLCQLPSLNELSMAGNRLAFLPLDLGRSRELQYVYVDNNIHLKGLPSYLYNKVIGCSGCGAPIQVSEVKLLSFSSGQLTVFLPAEVKAIGTEHDHVLPLQELAMRSLYHTYHSFLKDLNFLSPISLPRSLLELLHCPLGHCHRCSEPMFTIVYPKLFPLRETPMAGLHQGRTTVSFVAYCCSTQCLQTFDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VTX1</accession>
    <name>A0A8C5VTX1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="12">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PIM3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03009095">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645034.1">
        <property type="nucleotide sequence ID" value="XM_012789580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VTX1"/>
    <dbReference type="Ensembl" id="ENSMICT00000033007.2">
        <property type="protein sequence ID" value="ENSMICP00000025268.1"/>
        <property type="gene ID" value="ENSMICG00000037597.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885028"/>
    <dbReference type="KEGG" id="mmur:105885028"/>
    <dbReference type="CTD" id="415116"/>
    <dbReference type="GeneTree" id="ENSGT00940000153394"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061179">
        <property type="term" value="P:negative regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14102">
        <property type="entry name" value="STKc_PIM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000209">
        <property type="entry name" value="Serine/threonine-protein kinase pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000232">
        <property type="entry name" value="Serine/threonine-protein kinase pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017348">
        <property type="entry name" value="PIM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051138">
        <property type="entry name" value="PIM_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22984:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PIM-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037993">
        <property type="entry name" value="STPK_Pim-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="40"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="46"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037993-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="35734" checksum="1A41E89160A3AE00" modified="2022-01-19" version="1">MLLSKFGSLAHLCGPGGADHLPAKLLQPARADRESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGAAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGVLLYDMVCGDIPFEQDAEILRGHLFFRRRVSPECQQLIQWCLSLRPSERPSLDQIAAHPWMLGASGDTPETCDLRLCALDPDDGASTTSSSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VW95</accession>
    <name>A0A8C5VW95_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CLK1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03010920">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VW95"/>
    <dbReference type="Ensembl" id="ENSMICT00000054746.2">
        <property type="protein sequence ID" value="ENSMICP00000028420.2"/>
        <property type="gene ID" value="ENSMICG00000003361.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159722"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14213">
        <property type="entry name" value="PKc_CLK1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000061">
        <property type="entry name" value="Dual specificity protein kinase CLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000220">
        <property type="entry name" value="dual specificity protein kinase CLK4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE CLK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="233"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="155"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028420.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="556" mass="65111" checksum="322AC0C1A68C2CDC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWF1</accession>
    <name>A0A8C5VWF1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COX16</name>
        <name evidence="10" type="synonym">LOC105880279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003988">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636656.1">
        <property type="nucleotide sequence ID" value="XM_012781202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWF1"/>
    <dbReference type="Ensembl" id="ENSMICT00000049867.2">
        <property type="protein sequence ID" value="ENSMICP00000028512.2"/>
        <property type="gene ID" value="ENSMICG00000041985.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105880279"/>
    <dbReference type="GeneTree" id="ENSGT00520000055955"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028512.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="106" mass="12413" checksum="C061EBE8725CAC3C" modified="2022-01-19" version="1">MFAPEVMRALRKNKTLRYGVPMLLLIVGGSFGLREFSQIRYDAVKIKIDPELEKKLKENKVSLESEYEKIKDSTFDDWKNIRGPRPWEDTDLLQGRNPEILKTKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0D3</accession>
    <name>A0A8C5W0D3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proline rich 11</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03010910">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W0D3"/>
    <dbReference type="Ensembl" id="ENSMICT00000044107.2">
        <property type="protein sequence ID" value="ENSMICP00000034319.1"/>
        <property type="gene ID" value="ENSMICG00000033274.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046704"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF9">
        <property type="entry name" value="PROLINE-RICH PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36794" checksum="AD9A9E76C1BF00BB" modified="2022-01-19" version="1">MPKRKLKAKAKRLFKKREASHLQPKLITPPPPPPSPERVILSSTDISHSRSWLKSSWNFNFPNIRERIKLWTNRVWSCQNCIAQSLEVLKETIFASRICHRELQSLKQQFYILESELSLKAISESSACPSCGQTCHMNSTTVPACAVTTPGESRTGAVLPPTRTQPASYLPPPLPPPKSNLTKALQTRPLKKDEPMQITVKNLLTVKLKKTQGFDERRKLVPSPKARNPLVTVSDLQRVTLKPNSKVLSTRVTNVLIAPSKSQIDLRKLLRKEGAQVVPPLTNKENMDTGTGLTPVMTRALRRKFQLAHPRSSTQALPHSTSSFDEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1T0</accession>
    <name>A0A8C5W1T0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Solute carrier family 2, facilitated glucose transporter member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucose transporter type 1, erythrocyte/brain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC2A1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors. Required for mesendoderm differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603916.1">
        <property type="nucleotide sequence ID" value="XM_012748462.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1T0"/>
    <dbReference type="Ensembl" id="ENSMICT00000034602.2">
        <property type="protein sequence ID" value="ENSMICP00000031839.1"/>
        <property type="gene ID" value="ENSMICG00000014811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862274"/>
    <dbReference type="KEGG" id="mmur:105862274"/>
    <dbReference type="CTD" id="6513"/>
    <dbReference type="GeneTree" id="ENSGT00940000156792"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055056">
        <property type="term" value="F:D-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033300">
        <property type="term" value="F:dehydroascorbic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17431">
        <property type="entry name" value="MFS_GLUT_Class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000040">
        <property type="entry name" value="Solute carrier family 2, facilitated glucose transporter member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002439">
        <property type="entry name" value="Glu_transpt_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF51">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01190">
        <property type="entry name" value="GLUCTRSPORT1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="15"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="492" mass="54161" checksum="5CCBD3D91B693456" modified="2022-01-19" version="1">MEPSSKKLTGRLMLAVGGAVLGSLQFGYNTGVINAPQKVIEEFYNQTWIQRYGEPILPTTLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLMMNLLAFVSAVLMGFSKLGKSFEMLILGRFIIGVYCGLTTGFVPMYVGEVSPTALRGALGTLHQLGIVIGILIAQVFGLDSLMGNKDLWPLLLSIIFIPALLQCVVLPFCPESPRFLLINRNEENRAKSVLKKLRGTADVTHDLQEMKEESRQMMREKKVTILELFRSPAYRQPILIAVVLQLSQQLSGINAVFYYSTSIFEKAGVQQPVYATIGSGIFNTAFTVVSLFVVERAGRRTLHLIGLAGMAGCAVLMTIALALLEQLPWMSYLSIVAIFGFVAFFEVGPGPIPWFIVAELFSQGPRPAAIAVAGFSNWTSNFIVGMCFQYLEQLCGPYVFIIFTVLLILFFIFTYFKVPETKGRTFDEIASGFRQGGASQSDKTPEELFHPLGADSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2K0</accession>
    <name>A0A8C5W2K0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Protein SYS1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SYS1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein trafficking. May serve as a receptor for ARFRP1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARFRP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the SYS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2K0"/>
    <dbReference type="Ensembl" id="ENSMICT00000026869.2">
        <property type="protein sequence ID" value="ENSMICP00000035738.1"/>
        <property type="gene ID" value="ENSMICG00000028195.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154347"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016973">
        <property type="entry name" value="Integral_membrane_SYS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019185">
        <property type="entry name" value="Integral_membrane_SYS1-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952:SF0">
        <property type="entry name" value="PROTEIN SYS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12952">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09801">
        <property type="entry name" value="SYS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031402">
        <property type="entry name" value="SYS1_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR031402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="156" mass="17557" checksum="EA10AF8D2AAEBC77" modified="2022-01-19" version="1">MAGQFRSYVWDPLLILSQIVLMQAVYYGSLGLWLAVVDGLVRSSPSLDQMFDAEILGFSTPPGRLSMMSFVLNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWWLVQAVCIALMAVIGEYLCMRTELKEIPLNSAPKSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W304</accession>
    <name>A0A8C5W304_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptor 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">GPR62</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000035674.2"/>
        <property type="gene ID" value="ENSMICG00000037214.2"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182998"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1990763">
        <property type="term" value="F:arrestin family protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0038035">
        <property type="term" value="P:ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="probable G-protein coupled receptor 62"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF11">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <end position="118"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="149"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
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        <location>
            <begin position="31"/>
            <end position="290"/>
        </location>
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            <begin position="337"/>
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            <dbReference type="ARBA" id="ARBA00004337"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070735"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035674.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="362" mass="37360" checksum="814C1F9795444F95" modified="2022-01-19" version="1">MANTTELNVSEVASSIRLILAAVVEVGALLGNGAVLVVVLRTPGLRDALYLVHLCVVDLLAAASIMPLGLVAAPPPGLGRVRLGPASCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGSRPPPVLVLTTVWAAAGLLGALSLLGPPPAPPPAPARCSVLAGGLGPFRPLWALLAFALPALLLLGAYGSIFVVARRAALRPPRPARGARLRSDSLDSRLSILPPLRPHLPGGKAALAPGLAVGQFAACWLPYGCACLAPAARAAEAEAAVTWVAYTAFAAHPFLYGLLQRPVRLALGRLTRRALPRPPRACAPQAWHPRALLKCLQGHPEGPALGPSEAPERPPELAGGRSLSISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W3T5</accession>
    <name>A0A8C5W3T5_MICMU</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC105868016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026707">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W3T5"/>
    <dbReference type="Ensembl" id="ENSMICT00000027198.2">
        <property type="protein sequence ID" value="ENSMICP00000033025.1"/>
        <property type="gene ID" value="ENSMICG00000009289.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183123"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000048">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein a1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000109">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein a1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF2">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="228"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="280" mass="30266" checksum="D367F9ED4A5EB587" modified="2022-01-19" version="1">MSKSESPKEPEQLWKLFIGGLSFETTDESLRSHFEDPNTKRSRGFGFVTYTTVEEVDAAMNAQPHKVDGRVVEPKRAVSREDSQRPGAHLPVKKIFVGGIKEDTEEHHLRYYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKTVIQKYHTVSGHNCEVRKALWKQEMARASSSQSRGGGFGGNDNFGRGGTFSGGGGGYGGSGDGYNGFGNDGSNFGGGGSYNDFGNDNNQGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W631</accession>
    <name>A0A8C5W631_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002908">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W631"/>
    <dbReference type="Ensembl" id="ENSMICT00000037130.2">
        <property type="protein sequence ID" value="ENSMICP00000035805.1"/>
        <property type="gene ID" value="ENSMICG00000033640.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006238"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000002">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="115"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="195" mass="22642" checksum="E5321157939B5C6C" modified="2022-01-19" version="1">MPKSKRDKKVSLTQSAKKGLELKQNLLEELWKCVDTYKYLFIFSVANMRNSKLKDIQNAWKHSGMFFGKNKVMMVALGRSPSDEYKDNLPQVSKKLRVQEEVNEWFTKYTEMDFARAGNKATFTMSLDPRLLEQFPDSMEPQLRQLGLPTTLRRGVVTLLSDYKMCKEGDMLTPEQACVLKLFGYEMAEFKVTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W7A9</accession>
    <name>A0A8C5W7A9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iroquois homeobox 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IRX4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629615.1">
        <property type="nucleotide sequence ID" value="XM_012774161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W7A9"/>
    <dbReference type="Ensembl" id="ENSMICT00000035544.2">
        <property type="protein sequence ID" value="ENSMICP00000036585.1"/>
        <property type="gene ID" value="ENSMICG00000029233.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876480"/>
    <dbReference type="KEGG" id="mmur:105876480"/>
    <dbReference type="CTD" id="50805"/>
    <dbReference type="GeneTree" id="ENSGT00940000158596"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF16">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00548">
        <property type="entry name" value="IRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="518" mass="54696" checksum="586BAB9886644FAD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDS0</accession>
    <name>A0A8C5XDS0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Importin subunit beta-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Karyopherin subunit beta-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nuclear factor p97</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Pore targeting complex 97 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KPNB1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Forms a complex with an importin alpha subunit. Interacts with XPO1. Forms a heterodimer with IPO7. The KPNB1/IPO7 heterodimer interacts with H1 histone. Interacts with SNUPN. Interacts with H2A, H2B, H3 and H4 histones. Component of an import snRNP complex composed of KPNB1, SNUPN, SMN1 and ZNF259. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Interacts with SRY. Interacts with PRKCI/atypical protein kinase C iota. Interacts with KPNA2. Interacts with KPNA7. Interacts with SNAI1 (via zinc fingers) and SNAI2 (via zinc fingers). Interacts with SLC35G1 and STIM1. Interacts with DCAF8. Interacts with RAN. Interacts with NUMA1 (via C-terminus); this interaction is inhibited by RanGTP. Interacts with ZBED1/hDREF; required for nuclear import of ZBED1/hDREF. Interacts with SRP19. Interacts with RPL23A (via BIB domain), RPS7 and RPL5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the importin beta family. Importin beta-1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621422.2">
        <property type="nucleotide sequence ID" value="XM_012765968.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDS0"/>
    <dbReference type="Ensembl" id="ENSMICT00000012063.3">
        <property type="protein sequence ID" value="ENSMICP00000010981.3"/>
        <property type="gene ID" value="ENSMICG00000012059.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105872146"/>
    <dbReference type="CTD" id="3837"/>
    <dbReference type="GeneTree" id="ENSGT00550000074898"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071782">
        <property type="term" value="C:endoplasmic reticulum tubular network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042564">
        <property type="term" value="C:NLS-dependent protein nuclear import complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030953">
        <property type="term" value="P:astral microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040001">
        <property type="term" value="P:establishment of mitotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007079">
        <property type="term" value="P:mitotic chromosome movement towards spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045542">
        <property type="term" value="P:positive regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035332">
        <property type="term" value="P:positive regulation of hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006610">
        <property type="term" value="P:ribosomal protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006404">
        <property type="term" value="P:RNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000027">
        <property type="entry name" value="Importin subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="16">
        <location>
            <begin position="187"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="14">
        <location>
            <begin position="575"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010981.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1042" mass="114355" checksum="580006B6A42D6542" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XF20</accession>
    <name>A0A8C5XF20_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">U3 small nucleolar RNA-interacting protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RRP9 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">U3 small nucleolar ribonucleoprotein-associated 55 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">RRP9</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts specifically with the U3 small nucleolar RNA (U3 snoRNA). Binds a sub-fragment of the U3 snoRNA surrounding the B/C motif (3UBC). This association with the U3BC RNA is dependent on the binding of a protein called 15.5K to the box B/C motif. The association of the protein with the U3BC RNA was found to be also dependent on a conserved RNA structure that flanks the box B/C motif. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat RRP9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626928.1">
        <property type="nucleotide sequence ID" value="XM_012771474.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XF20"/>
    <dbReference type="Ensembl" id="ENSMICT00000017292.3">
        <property type="protein sequence ID" value="ENSMICP00000015751.2"/>
        <property type="gene ID" value="ENSMICG00000017291.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875030"/>
    <dbReference type="KEGG" id="mmur:105875030"/>
    <dbReference type="CTD" id="9136"/>
    <dbReference type="GeneTree" id="ENSGT00940000158328"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000143">
        <property type="entry name" value="U3 small nucleolar RNA-interacting protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="140"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="193"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="318"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015751.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="476" mass="52025" checksum="5809FC607D9F458B" modified="2022-01-19" version="1">MSASVAAYKRGKSASSASAGASKRRRKADSAGDKGKSKGGGKMNEEISSDSENESPAPRRTEEEEEEELEETAQEKKLRLAKLYLEQLRQQEDEKAEAFAFEEDQVAGRLREDVLEQKGRLQKSVAKEIQAPALSDIRVLRGHQLSITCLVITPDDLAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGQPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCRHLYTFTGHRDAVSGLAFRRGTHQLYSASHDRAVKVWNAAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWVSSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDHLCDIPLVGFINSLKFSSTGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPAAPAAPAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGG5</accession>
    <name>A0A8C5XGG5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cadherin related family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CDHR2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03028896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028899">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028904">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000055263.2">
        <property type="protein sequence ID" value="ENSMICP00000019907.2"/>
        <property type="gene ID" value="ENSMICG00000027886.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161160"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090675">
        <property type="term" value="P:intermicrovillar adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060243">
        <property type="term" value="P:negative regulation of cell growth involved in contact inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032532">
        <property type="term" value="P:regulation of microvillus length"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000245">
        <property type="entry name" value="Cadherin related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000252">
        <property type="entry name" value="Cadherin related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000098">
        <property type="entry name" value="cadherin-23 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cadherin-related family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000094">
        <property type="entry name" value="protocadherin gamma-C4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF411">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034382945" evidence="15">
        <location>
            <begin position="21"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1067"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="120"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="237"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="362"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="548"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="664"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="869"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019907.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1221" mass="131588" checksum="7A646D3DACB61565" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHI1</accession>
    <name>A0A8C5XHI1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho guanine nucleotide exchange factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARHGEF4</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011562">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5XHI1"/>
    <dbReference type="Ensembl" id="ENSMICT00000037154.2">
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        <property type="gene ID" value="ENSMICG00000009501.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160622"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01224">
        <property type="entry name" value="PH_Collybistin_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11973">
        <property type="entry name" value="SH3_ASEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000002">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000077">
        <property type="entry name" value="spermatogenesis-associated protein 13 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DBL_dom_sf"/>
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        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055251">
        <property type="entry name" value="SOS1_NGEF_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47544:SF2">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22697">
        <property type="entry name" value="SOS1_NGEF_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RhoGEF"/>
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    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DBL homology domain (DH-domain)"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50002">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="196"/>
            <end position="380"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="518"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022991.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="602" mass="69188" checksum="512D6417F4B8AFBB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJG2</accession>
    <name>A0A8C5XJG2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Angiopoietin-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Angiopoietin-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ANGPTL3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with ANGPTL8. Interacts with ITGB3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001405">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJG2"/>
    <dbReference type="Ensembl" id="ENSMICT00000029843.2">
        <property type="protein sequence ID" value="ENSMICP00000028874.2"/>
        <property type="gene ID" value="ENSMICG00000001535.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156746"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005577">
        <property type="term" value="C:fibrinogen complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035473">
        <property type="term" value="F:lipase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004859">
        <property type="term" value="F:phospholipase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048844">
        <property type="term" value="P:artery morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072377">
        <property type="term" value="P:blood coagulation, common pathway"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010903">
        <property type="term" value="P:negative regulation of very-low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055091">
        <property type="term" value="P:phospholipid homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070527">
        <property type="term" value="P:platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050996">
        <property type="term" value="P:positive regulation of lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090318">
        <property type="term" value="P:regulation of chylomicron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000008">
        <property type="entry name" value="Angiopoietin like 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.215.10">
        <property type="entry name" value="Gamma Fibrinogen, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037579">
        <property type="entry name" value="FIB_ANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014716">
        <property type="entry name" value="Fibrinogen_a/b/g_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221">
        <property type="entry name" value="FIBRINOGEN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47221:SF5">
        <property type="entry name" value="FIBRINOGEN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00147">
        <property type="entry name" value="Fibrinogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00186">
        <property type="entry name" value="FBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034328104" description="Angiopoietin-related protein 3" evidence="17">
        <location>
            <begin position="17"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="18">
        <location>
            <begin position="238"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="92"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="460" mass="53809" checksum="0ECDBD04BDBB9E15" modified="2022-01-19" version="1">MYMIKIFLFIVPVVISSRIDQDNSSLDTISSEPISRFAMLDDVKILANGLLQLGHGLKDFVHKTKGQINDIFKKLNIFDQSFYDLSLQTNEIKEEEKELRRTTYKLQVKNEEVKNMSLELNSKLENLLEEKILLQQKVRYLEEQLTNLIQNQPETQEHPAVTSLKTFVEQQDNSIKDLLQTVEEQYKQLNQQHSQIKEIENQLRRTGIQEPTENSLSSKPRAPRTTPFLQLNEIKKNVEHDGIPPDCTTIYNRGEHTSGMYAIRPSNAQVFNVYCDVKSGSPWTLIQRRADGSQNFNETWENYKYGFGRLDGEFWLGLEKIYSIVKQSNYILRFELEDWKDNKYYIEYSFHLGDHETNYTLHLVEITGNIHNALPENKDLVFSTWDHKAKGHFNCPESSSGGWWWHDVCGENNLNGKYNKPRTKSKPERRRGICWKSQNGRLYSIKSTKMLIHPTDESFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XL82</accession>
    <name>A0A8C5XL82_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105858224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028657">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XL82"/>
    <dbReference type="Ensembl" id="ENSMICT00000050546.2">
        <property type="protein sequence ID" value="ENSMICP00000033767.2"/>
        <property type="gene ID" value="ENSMICG00000007861.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163771"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042445">
        <property type="term" value="P:hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19108">
        <property type="entry name" value="AKR_AKR1C1-35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000003">
        <property type="entry name" value="Aldo-keto reductase family 1 member C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044482">
        <property type="entry name" value="AKR1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="322" mass="36855" checksum="C225D6BE7991B1C6" modified="2022-01-19" version="1">MDPKYQRVELNDGHSIPVLGFGTYAPPEVPKSRTVEATKYAIEAGFRHIDAAYLYENEEQVGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALERSLKKLQLDYVDLYLIHSPVSFKPAEELIPKGEDGKPLYDTVDLRATWEALEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGTQRDKRWVDPSSPVLLEDPVCALAKKHKRTPALVALRYQLQRGVVVLAKSFNEQRIRENMQVFEFELTAEDMKVLDGLNRNLRYFNSDILSGHPNYPFSDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XMD2</accession>
    <name>A0A8C5XMD2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="20">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">POLR3B</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits: a ten-subunit catalytic core composed of POLR3A/RPC1, POLR3B/RPC2, POLR1C/RPAC1, POLR1D/RPAC2, POLR3K/RPC10, POLR2E/RPABC1, POLR2F/RPABC2, POLR2H/RPABC3, POLR2K/RPABC4 and POLR2L/RPABC5; a mobile stalk composed of two subunits POLR3H/RPC8 and CRCP/RPC9, protruding from the core and functioning primarily in transcription initiation; and additional subunits homologous to general transcription factors of the RNA polymerase II machinery, POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer required for transcription initiation and POLR3D/RPC4-POLR3E/RPC5 heterodimer involved in both transcription initiation and termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="20"/>
    <dbReference type="EMBL" id="ABDC03009206">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628209.1">
        <property type="nucleotide sequence ID" value="XM_012772755.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XMD2"/>
    <dbReference type="Ensembl" id="ENSMICT00000035848.2">
        <property type="protein sequence ID" value="ENSMICP00000037005.1"/>
        <property type="gene ID" value="ENSMICG00000008910.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875609"/>
    <dbReference type="KEGG" id="mmur:105875609"/>
    <dbReference type="CTD" id="55703"/>
    <dbReference type="GeneTree" id="ENSGT00950000183132"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071667">
        <property type="term" value="F:DNA/RNA hybrid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045089">
        <property type="term" value="P:positive regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15 20" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="24">
        <location>
            <begin position="38"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="186"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="25">
        <location>
            <begin position="438"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="26">
        <location>
            <begin position="539"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="27">
        <location>
            <begin position="621"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="21">
        <location>
            <begin position="668"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="1043"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1133" mass="127775" checksum="CF6918A16F69CB19" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNZ6</accession>
    <name>A0A8C5XNZ6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNZ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000031832.2">
        <property type="protein sequence ID" value="ENSMICP00000038526.1"/>
        <property type="gene ID" value="ENSMICG00000030505.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154399"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF12">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="77" mass="9274" checksum="CDFD6C9E9903A750" modified="2022-01-19" version="1">KNRRLKQAKEEAQAETEQYGLQREKEFKAKEASKETQEKMTMVQTYFHQNRDEVLDNLLAFVCYIRPEIHENYHING</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XP00</accession>
    <name>A0A8C5XP00_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase RING2</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING finger protein 1B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">RING finger protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase RING2</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03021172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XP00"/>
    <dbReference type="Ensembl" id="ENSMICT00000044449.2">
        <property type="protein sequence ID" value="ENSMICP00000038543.1"/>
        <property type="gene ID" value="ENSMICG00000031137.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154499"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
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        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:PcG protein complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:ubiquitin ligase complex"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RAWUL_RING2"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd16740">
        <property type="entry name" value="RING-HC_RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000067">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="RAWUL"/>
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        <property type="entry name" value="RING1/RING2"/>
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    <dbReference type="InterPro" id="IPR037937">
        <property type="entry name" value="RING2_RAWUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1 / RING 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46076:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0678">Repressor</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="156"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030504"/>
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            <dbReference type="ARBA" id="ARBA00030910"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="325" mass="36495" checksum="26C8275C08040F70" modified="2022-01-19" version="1">MSQAVQTNGTQPLSKTWELRLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLYMLKNTMTTKECLHCFCGVITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYLSRDEYEAHRERVLARINKHKNQHALSHSMEEGLKIQAVNRLQRGKKQQIENGSGAEGNGDTGPSDKRTKTSDVSGLDDSNAAAAIDPVMDGASEIELVFRPHPTLMEKDDSAQTRYLETSGNATVDHLSKYLAERLALEELRSKGESDQMNLDTASEKQYTIYIATASGQFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHKGAFNNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTV7</accession>
    <name>A0A8C5XTV7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Keratin associated protein 6-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KRTAP6-1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRTAP type 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTV7"/>
    <dbReference type="Ensembl" id="ENSMICT00000008596.3">
        <property type="protein sequence ID" value="ENSMICP00000041361.1"/>
        <property type="gene ID" value="ENSMICG00000034583.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183372"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040313">
        <property type="entry name" value="KAP6"/>
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    <dbReference type="PANTHER" id="PTHR31678:SF2">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 6-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31678">
        <property type="entry name" value="KERATIN-ASSOCIATED PROTEIN 6-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0416">Keratin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00008687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="67" mass="6774" checksum="A6BBC2344C981DC1" modified="2022-01-19" version="1">MCGSYYGNYYGGRGYGGCGYGGLGYGYGGLGCGYGCGYGCGFRRLGCGYGCGYGCGSGYGSGFGYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUJ2</accession>
    <name>A0A8C5XUJ2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Retinol dehydrogenase 16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUJ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000063599.1">
        <property type="protein sequence ID" value="ENSMICP00000041209.1"/>
        <property type="gene ID" value="ENSMICG00000047530.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154118"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF11">
        <property type="entry name" value="RETINOL DEHYDROGENASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="20759" checksum="C7D75F2EB9960BA5" modified="2022-01-19" version="1">VVSHLRDKYVFITGCGSGFGNLLARQLDMRGMRVLAACRTEKAAEQLRAQASDRLETVTLDVTKTDSITAAAQWVKECVGDRGLWGLVNNTGIAMPLGPIEWLTKEDFVTILGVNLLGMIEVTLSLLPLVRKARGRVVNVSSIAGRMAITGGGYCISKFGVEAFSDSLRCCPGIGPCLSPPVPGPLWEHFARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVJ1</accession>
    <name>A0A8C5XVJ1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Major histocompatibility complex, class II, DM beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HLA-DMB</name>
        <name evidence="18" type="synonym">LOC105886010</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Late endosome membrane</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XVJ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000063983.1">
        <property type="protein sequence ID" value="ENSMICP00000042105.1"/>
        <property type="gene ID" value="ENSMICG00000043729.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160381"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023026">
        <property type="term" value="F:MHC class II protein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019886">
        <property type="term" value="P:antigen processing and presentation of exogenous peptide antigen via MHC class II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002503">
        <property type="term" value="P:peptide antigen assembly with MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001190">
        <property type="term" value="P:positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21002">
        <property type="entry name" value="IgC1_MHC_II_beta_HLA-DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000968">
        <property type="entry name" value="MHC class II H2-M beta 2 chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF65">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0491">MHC II</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033981617" evidence="16">
        <location>
            <begin position="19"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="114"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="263" mass="28800" checksum="66785377C0C39E44" modified="2022-01-19" version="1">MATLLPLLLGLSLGCIGAGGFVAHVESTCLLDDDGTAQDFTYCISFNKDLLTCWDQQEEKMAPCEFGVLNGLASYLSDYLNQQGTLLQRLRSGLQDCATHTQPFWGSLTHRTRPPTVQVAQTTPFNTREPVMLACYVWGFYPADVTITWRKNGQPVTPHNSAQKTSQPNGDWTYQTLSHLALTPSYGDTYTCVVEHVGAPEPILQDWTPVLSPMQTVKVSVSAVTLGLGLIIFSLGLISWRRAASSSYIPLPGSSYPEGRHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XWZ3</accession>
    <name>A0A8C5XWZ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit E-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EIF3L</name>
        <name evidence="4" type="synonym">EIF3EIP</name>
        <name evidence="4" type="synonym">EIF3S6IP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034108">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XWZ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000064978.1">
        <property type="protein sequence ID" value="ENSMICP00000042765.1"/>
        <property type="gene ID" value="ENSMICG00000035434.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000411"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="361"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="594" mass="69467" checksum="6D63EB8046E533B0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXS7</accession>
    <name>A0A8C5XXS7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CGG triplet repeat binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CGGBP1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03032815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606439.1">
        <property type="nucleotide sequence ID" value="XM_012750985.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXS7"/>
    <dbReference type="Ensembl" id="ENSMICT00000067455.1">
        <property type="protein sequence ID" value="ENSMICP00000043102.1"/>
        <property type="gene ID" value="ENSMICG00000047167.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105863644"/>
    <dbReference type="GeneTree" id="ENSGT00390000017898"/>
    <dbReference type="OrthoDB" id="9434539at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033375">
        <property type="entry name" value="Cggbp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32344:SF1">
        <property type="entry name" value="U1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="167" mass="18806" checksum="1AF39C88530D63AD" modified="2022-01-19" version="1">MERFVVTAPPARNRSKTALYVTPLDRVSEFGGELHEDGGKLFCTSCNVVLNHVRKSAISDHLKSKTHTKRKAEFEEQNVRKKQRPLTASLQCNSTAQTEKVSVIQDFVKMCLEANIPLEKADHPAVRAFLSRHVKNGGSIPKSDQLRRAYLPDGYENENQLLNSQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y335</accession>
    <name>A0A8C5Y335_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium-activated potassium channel subunit alpha-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">BK channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">BKCA alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Calcium-activated potassium channel, subfamily M subunit alpha-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">K(VCA)alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">KCa1.1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Maxi K channel</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Slo-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Slo1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Slowpoke homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">KCNMA1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018974">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y335"/>
    <dbReference type="Ensembl" id="ENSMICT00000064411.1">
        <property type="protein sequence ID" value="ENSMICP00000044828.1"/>
        <property type="gene ID" value="ENSMICG00000010913.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154935"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060072">
        <property type="term" value="F:large conductance calcium-activated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000098">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000005">
        <property type="entry name" value="calcium-activated potassium channel subunit alpha-1 isoform X6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000015">
        <property type="entry name" value="Calcium-activated potassium channel subunit alpha-1 isoform X7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048735">
        <property type="entry name" value="Slowpoke-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF40">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22614">
        <property type="entry name" value="Slo-like_RCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21014">
        <property type="entry name" value="Slowpoke_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01449">
        <property type="entry name" value="BKCHANNELA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="30">
        <location>
            <begin position="405"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="30">
        <location>
            <begin position="844"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="762"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1191"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="28">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="1191"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="1225"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00030518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00031999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138231" checksum="5CBE482A4817BB6C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7I8</accession>
    <name>A0A8C5Y7I8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="15">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 13 14">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03036460">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7I8"/>
    <dbReference type="Ensembl" id="ENSMICT00000066748.1">
        <property type="protein sequence ID" value="ENSMICP00000046940.1"/>
        <property type="gene ID" value="ENSMICG00000046904.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161569"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004673">
        <property type="term" value="F:protein histidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Nucleoside diphosphate kinase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
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        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
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        <property type="entry name" value="NDK"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="16">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="13">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004013"/>
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        <source>
            <dbReference type="SMART" id="SM00562"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="152" mass="17241" checksum="AA8634EEC7A8555B" modified="2022-01-19" version="1">MANLERTFIAVKPDGVQRGLVGEIIKCFEQKGFRLVALKLLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPIVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7M0</accession>
    <name>A0A8C5Y7M0_MICMU</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7M0"/>
    <dbReference type="Ensembl" id="ENSMICT00000063289.1">
        <property type="protein sequence ID" value="ENSMICP00000046976.1"/>
        <property type="gene ID" value="ENSMICG00000045835.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153524"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="125" mass="13815" checksum="25A93CA0108788EA" modified="2022-01-19" version="1">MSSEEEKPFVGGLNFNTNEQVLEDHFSSSGPISEAVVVKDRETQRSRGFGFITFTNPDMPHLVPDGCQIRVDYDGKSARGTRGGFGSYGRGHSYSRGGGDRYGSWIWKGGYDRYSGGNDRDNYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y883</accession>
    <name>A0A8C5Y883_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-4 complex accessory subunit RUSC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Interacting protein of Rab1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RUN and SH3 domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RUSC2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associated component of the adapter-like complex 4 (AP-4). Interacts with active RAB1A and RAB1B, and with GOLGA2. Interacts (via RUN domain) with RAB35 (GTP-bound form); the interaction recruits RUSC2 to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03014786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000059346.1">
        <property type="protein sequence ID" value="ENSMICP00000047228.1"/>
        <property type="gene ID" value="ENSMICG00000043963.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141033"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Strepsirrhini</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="11">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="11584" checksum="5028B99E802AE215" modified="2022-01-19" version="1">QPVLTQPPSASASPGASAKLTCTLSSAHSDYTIAWLQQQPGKAPRYLMDIYSDGSQSKGDGVPDRFSGSSSGADRYLTISNVQPEDEADYYCQSYDASASHTVLQSMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y9D7</accession>
    <name>A0A8C5Y9D7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein lin-7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LIN7C</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules. This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Postsynaptic density membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the lin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006289">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600109.1">
        <property type="nucleotide sequence ID" value="XM_012744655.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y9D7"/>
    <dbReference type="SMR" id="A0A8C5Y9D7"/>
    <dbReference type="Ensembl" id="ENSMICT00000060103.1">
        <property type="protein sequence ID" value="ENSMICP00000048067.1"/>
        <property type="gene ID" value="ENSMICG00000005165.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860147"/>
    <dbReference type="KEGG" id="mmur:105860147"/>
    <dbReference type="CTD" id="55327"/>
    <dbReference type="GeneTree" id="ENSGT00940000153222"/>
    <dbReference type="OMA" id="RFDKQRM"/>
    <dbReference type="OrthoDB" id="10056216at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097025">
        <property type="term" value="C:MPP7-DLG1-LIN7 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097016">
        <property type="term" value="F:L27 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002011">
        <property type="term" value="P:morphogenesis of an epithelial sheet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06796">
        <property type="entry name" value="PDZ_Lin-7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000076">
        <property type="entry name" value="Protein lin-7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017365">
        <property type="entry name" value="LIN7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051109">
        <property type="entry name" value="MAM_complex_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14063">
        <property type="entry name" value="PROTEIN LIN-7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038039">
        <property type="entry name" value="Lin-7_homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00569">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51022">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 15" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="4" id="KW-0796">Tight junction</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="L27" evidence="17">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="16">
        <location>
            <begin position="93"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="197" mass="21834" checksum="7410FBFA3BD24F45" modified="2022-01-19" version="1">MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y9K1</accession>
    <name>A0A8C5Y9K1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">High mobility group AT-hook 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HMGA2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009762">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637855.1">
        <property type="nucleotide sequence ID" value="XM_012782401.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143128.1">
        <property type="nucleotide sequence ID" value="XM_020287539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y9K1"/>
    <dbReference type="Ensembl" id="ENSMICT00000060314.1">
        <property type="protein sequence ID" value="ENSMICP00000047374.1"/>
        <property type="gene ID" value="ENSMICG00000029622.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880976"/>
    <dbReference type="CTD" id="8091"/>
    <dbReference type="GeneTree" id="ENSGT00940000163109"/>
    <dbReference type="OrthoDB" id="9946651at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000637">
        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341:SF4">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN HMGI-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23341">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEINS HMG-A AND C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00354">
        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="11832" checksum="F36BABE623DA4615" modified="2022-01-19" version="1">MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQEETEETSSQESAEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAN8</accession>
    <name>A0A8C5YAN8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EMC4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004566">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598324.1">
        <property type="nucleotide sequence ID" value="XM_012742870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAN8"/>
    <dbReference type="Ensembl" id="ENSMICT00000060872.1">
        <property type="protein sequence ID" value="ENSMICP00000048632.1"/>
        <property type="gene ID" value="ENSMICG00000003864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859226"/>
    <dbReference type="KEGG" id="mmur:105859226"/>
    <dbReference type="CTD" id="51234"/>
    <dbReference type="GeneTree" id="ENSGT00390000006970"/>
    <dbReference type="OMA" id="FMMWMVG"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="183" mass="20117" checksum="D287FB92EB2DA805" modified="2022-01-19" version="1">MTAQGSLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEE4</accession>
    <name>A0A8C5YEE4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Receptor-type tyrosine-protein phosphatase U</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Pancreatic carcinoma phosphatase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Receptor-type protein-tyrosine phosphatase psi</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">PTPRU</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Forms homooligomeric complexes which mediate cell homotypic adhesion. Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT. May interact with AP3B1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03001764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001765">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606226.1">
        <property type="nucleotide sequence ID" value="XM_012750772.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068996.1">
        <property type="protein sequence ID" value="ENSMICP00000049049.1"/>
        <property type="gene ID" value="ENSMICG00000008985.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105863544"/>
    <dbReference type="CTD" id="10076"/>
    <dbReference type="GeneTree" id="ENSGT00940000157151"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034109">
        <property type="term" value="P:homotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000049">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034394">
        <property type="term" value="P:protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14632">
        <property type="entry name" value="R-PTPc-U-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14637">
        <property type="entry name" value="R-PTPc-U-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000019">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase kappa isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000009">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000048">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000019">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000022">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000025">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000014">
        <property type="entry name" value="receptor-type tyrosine-protein phosphatase U isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057598">
        <property type="entry name" value="Fn3_PTPRU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051622">
        <property type="entry name" value="R-tyr_protein_phosphatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051:SF10">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE U-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24051">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23144">
        <property type="entry name" value="Fn3_PTPRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00020">
        <property type="entry name" value="MAMDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00740">
        <property type="entry name" value="MAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="15 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 28" id="KW-0732">Signal</keyword>
    <keyword evidence="6 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150543" description="Receptor-type tyrosine-protein phosphatase U" evidence="28">
        <location>
            <begin position="19"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="31">
        <location>
            <begin position="25"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="288"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="386"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="32">
        <location>
            <begin position="485"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="29">
        <location>
            <begin position="918"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="30">
        <location>
            <begin position="1070"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="29">
        <location>
            <begin position="1182"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="30">
        <location>
            <begin position="1361"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="832"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00063907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00073602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00076349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00083361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1452" mass="163207" checksum="A3D5E54D5780ADCA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YES4</accession>
    <name>A0A8C5YES4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fraser extracellular matrix complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FRAS1</name>
        <name evidence="10" type="synonym">LOC105860481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the FRAS1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="3" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="52"/>
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        <location>
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    <feature type="domain" description="VWFC" evidence="9">
        <location>
            <begin position="178"/>
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    <feature type="domain" description="VWFC" evidence="9">
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            <begin position="242"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="14">Interacts with SLC16A1, SLC16A6 and SLC16A7.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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            <location evidence="13">Synapse</location>
        </subcellularLocation>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0098632">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0070593">
        <property type="term" value="P:dendrite self-avoidance"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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    <dbReference type="PANTHER" id="PTHR10075">
        <property type="entry name" value="BASIGIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10075:SF4">
        <property type="entry name" value="EMBIGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034266424" description="Embigin" evidence="18">
        <location>
            <begin position="33"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="73"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="161"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="329" mass="36774" checksum="E552DD7A3F58BDD8" modified="2022-01-19" version="1">MRAVPGLRGPRGPTPGLLSFLCLLAAARPSLADGGDPDSPFTSLPVQEEMMEKYNNLSMESYNISLTEQSSMPVEKNITLDRPSNIQLTCQLTTSRDLNSVNVTWKKGDEILENNYLINATGNILYTQHMFTITNSKQMGSYSCFFQEEKEQRGTFNFRVPKVHGRNKPLISYVGDSTVLTCKCEGCFPLNWTWYSSNGSVQVPVGIQKNMYVKNGTYANETSLKITELLEGDGGSYWCRALFQLGESEDHIELVVLSFLVPLKPFLAIVGEVVLLVTIILLCEKYTQKKQLDSGTEKEFEQIEQLKSDDSNGIENNAPRLRKTEPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHG2</accession>
    <name>A0A8C5YHG2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 33 member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC33A1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>acetyl-CoA(in) = acetyl-CoA(out)</text>
            <dbReference type="Rhea" id="RHEA:75039"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:75040"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SLC33A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629812.1">
        <property type="nucleotide sequence ID" value="XM_012774358.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629813.1">
        <property type="nucleotide sequence ID" value="XM_012774359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHG2"/>
    <dbReference type="Ensembl" id="ENSMICT00000072279.1">
        <property type="protein sequence ID" value="ENSMICP00000051524.1"/>
        <property type="gene ID" value="ENSMICG00000048976.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105876654"/>
    <dbReference type="KEGG" id="mmur:105876654"/>
    <dbReference type="CTD" id="9197"/>
    <dbReference type="GeneTree" id="ENSGT00940000154019"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000287">
        <property type="entry name" value="acetyl-coenzyme A transporter 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="260"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="550" mass="61349" checksum="2239D2FAF5A794AE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHX9</accession>
    <name>A0A8C5YHX9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Signal recognition particle 14 kDa protein</fullName>
            <shortName evidence="10">SRP14</shortName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHX9"/>
    <dbReference type="Ensembl" id="ENSMICT00000073211.1">
        <property type="protein sequence ID" value="ENSMICP00000051094.1"/>
        <property type="gene ID" value="ENSMICG00000049361.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000247044"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="12317" checksum="3CE2101AE46B729E" modified="2022-01-19" version="1">MVLLESEQFLTQLTRLFRQCQLSSSRQSVFIILKKYDRLEGFDPSDKKCLLRATDGKKKLTNMHGLKKRDKTNMSKKSKTAHTAYTTVNNTGMLAALIELTFTDGASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YI50</accession>
    <name>A0A8C5YI50_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 15">Transferrin receptor protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TFRC</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cell membrane</location>
            <topology evidence="15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="15">Stearoylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001061">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YI50"/>
    <dbReference type="Ensembl" id="ENSMICT00000071115.2">
        <property type="protein sequence ID" value="ENSMICP00000051698.1"/>
        <property type="gene ID" value="ENSMICG00000048390.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234598"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990712">
        <property type="term" value="C:HFE-transferrin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004998">
        <property type="term" value="F:transferrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010637">
        <property type="term" value="P:negative regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045830">
        <property type="term" value="P:positive regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900182">
        <property type="term" value="P:positive regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031334">
        <property type="term" value="P:positive regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033572">
        <property type="term" value="P:transferrin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09848">
        <property type="entry name" value="M28_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02128">
        <property type="entry name" value="PA_TfR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000002">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000045">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000010">
        <property type="entry name" value="Transferrin receptor protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
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        <property type="entry name" value="PA_domain"/>
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        <property type="entry name" value="TfR1/2_PA"/>
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    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRANSFERRIN RECEPTOR PROTEIN 1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
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        <property type="entry name" value="Peptidase_M28"/>
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        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 15" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 15" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13 15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
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        <location>
            <begin position="228"/>
            <end position="298"/>
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    <feature type="domain" description="Peptidase M28" evidence="18">
        <location>
            <begin position="387"/>
            <end position="575"/>
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    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="17">
        <location>
            <begin position="636"/>
            <end position="748"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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    <sequence length="759" mass="85439" checksum="541B04622469D9B6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EC13</accession>
    <name>A0A8B7EC13_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nipped-B protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NIPBL</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner. Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SCC2/Nipped-B family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000023868.2"/>
        <property type="gene ID" value="ENSMICG00000012468.3"/>
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        <property type="component" value="Chromosome 12"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:Scc2-Scc4 cohesin loading complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:histone deacetylase binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:mediator complex binding"/>
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        <property type="term" value="F:promoter-specific chromatin binding"/>
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        <property type="term" value="F:transcription corepressor activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:brain development"/>
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        <property type="term" value="P:cellular response to X-ray"/>
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        <property type="term" value="P:chromatin looping"/>
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        <property type="term" value="P:cognition"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:developmental growth"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:ear morphogenesis"/>
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        <property type="term" value="P:embryonic digestive tract morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:embryonic viscerocranium morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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    <dbReference type="GO" id="GO:0040018">
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        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061038">
        <property type="term" value="P:uterus morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23958">
        <property type="entry name" value="SCC2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nipped-B protein"/>
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        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="ARM-like"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033031">
        <property type="entry name" value="Scc2/Nipped-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704:SF18">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21704">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN DELANGIN SCC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sister chromatid cohesion C-terminal" evidence="13">
        <location>
            <begin position="2278"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="483"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1019"/>
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1694"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2476"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2654"/>
            <end position="2699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="128"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="161"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="191"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="234"/>
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    </feature>
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        <location>
            <begin position="286"/>
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            <begin position="332"/>
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            <begin position="442"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="12">
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            <begin position="452"/>
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            <begin position="483"/>
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            <begin position="524"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="563"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="594"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="673"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
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            <begin position="695"/>
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            <begin position="1111"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="12">
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        <location>
            <begin position="2513"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009252"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058410"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364107"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023868.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2807" mass="316519" checksum="915C919913CA8FC7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EFL2</accession>
    <name>A0A8B7EFL2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-galactoside alpha-2,6-sialyltransferase 2</fullName>
            <ecNumber evidence="18">2.4.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">ST6Gal II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Sialyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ST6GAL2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-galactoside + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2-&gt;6)-beta-D-galactosyl derivative + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28034"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:136398"/>
            <dbReference type="EC" id="2.4.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.3.1" evidence="18"/>
    <dbReference type="EMBL" id="ABDC03005416">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593091.1">
        <property type="nucleotide sequence ID" value="XM_012737637.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593092.1">
        <property type="nucleotide sequence ID" value="XM_012737638.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593093.1">
        <property type="nucleotide sequence ID" value="XM_012737639.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593094.1">
        <property type="nucleotide sequence ID" value="XM_012737640.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593095.1">
        <property type="nucleotide sequence ID" value="XM_012737641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EFL2"/>
    <dbReference type="Ensembl" id="ENSMICT00000066769.1">
        <property type="protein sequence ID" value="ENSMICP00000042863.1"/>
        <property type="gene ID" value="ENSMICG00000042257.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069843.1">
        <property type="protein sequence ID" value="ENSMICP00000050452.1"/>
        <property type="gene ID" value="ENSMICG00000042257.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105856143"/>
    <dbReference type="KEGG" id="mmur:105856143"/>
    <dbReference type="CTD" id="84620"/>
    <dbReference type="GeneTree" id="ENSGT00940000158714"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003835">
        <property type="term" value="F:beta-galactoside alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23986">
        <property type="entry name" value="GT29_ST6GAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000010">
        <property type="entry name" value="ST6 beta-galactoside alpha-2,6-sialyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46059">
        <property type="entry name" value="BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46059:SF3">
        <property type="entry name" value="BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="526" mass="59746" checksum="7B8532AD5B4D8A1F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ERQ7</accession>
    <name>A0A8B7ERQ7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">tRNA-dihydrouridine(20) synthase [NAD(P)+]-like</fullName>
            <ecNumber evidence="16">1.3.1.91</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Dihydrouridine synthase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">tRNA-dihydrouridine synthase 2-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DUS2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20 in cytoplasmic tRNAs. Activity depends on the presence of guanosine at position 19 in the tRNA substrate. Negatively regulates the activation of EIF2AK2/PKR.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(20) in tRNA + NADP(+) = uridine(20) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53336"/>
            <dbReference type="Rhea" id="RHEA-COMP:13533"/>
            <dbReference type="Rhea" id="RHEA-COMP:13534"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.91"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53338"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with EPRS1. Interacts (via DRBM domain) with PRKRA and EIF2AK2/PKR (via DRBM 1 domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Dus family. Dus2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.91" evidence="16"/>
    <dbReference type="EMBL" id="ABDC03024306">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597793.1">
        <property type="nucleotide sequence ID" value="XM_012742339.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597794.1">
        <property type="nucleotide sequence ID" value="XM_012742340.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597795.1">
        <property type="nucleotide sequence ID" value="XM_012742341.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597796.1">
        <property type="nucleotide sequence ID" value="XM_012742342.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597797.1">
        <property type="nucleotide sequence ID" value="XM_012742343.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597798.1">
        <property type="nucleotide sequence ID" value="XM_012742344.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138073.1">
        <property type="nucleotide sequence ID" value="XM_020282484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ERQ7"/>
    <dbReference type="Ensembl" id="ENSMICT00000068460.1">
        <property type="protein sequence ID" value="ENSMICP00000045123.1"/>
        <property type="gene ID" value="ENSMICG00000011354.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858921"/>
    <dbReference type="CTD" id="54920"/>
    <dbReference type="GeneTree" id="ENSGT00550000075019"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102264">
        <property type="term" value="F:tRNA-dihydrouridine20 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19871">
        <property type="entry name" value="DSRM_DUS2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000148">
        <property type="entry name" value="tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044463">
        <property type="entry name" value="DUS2_DSRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DRBM" evidence="21">
        <location>
            <begin position="370"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="438"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="493" mass="55342" checksum="EF8D3DF076410815" modified="2022-01-19" version="1">MIVNSLSLCYRNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMLQCKRVVNEALSTVDFVAPDDRVVFRTCEREQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKEYSTKGGMGAALLSDPDRIEKILSTLVKGTRRPVTCKIRILPSLEDTLNLVKRIERTGIAAIAVHGRKREERPQHPVSCDVIRAIADALSIPVIANGGSHDHIQQYLDIEDFRQATAASSVMVARAAMWNPSIFLKEGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSQEICEAFGLGAFYEETTQQLDARRARLLARTPEEAEEPAEDASGVIKMAVRFDRRAYPPQITPKMCLLEWCRREKLAQPVYETVQRPLDRLFCSVVTVAEQKYQSTLWDKSKKLAEQAAAIVCLRSQGLPEGRLGEESPSLHKRKREAPDQDPGSPRAQEPALCGELCKKPFVDLANGEETPLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EV47</accession>
    <name>A0A8B7EV47_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">CREBBP</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(S)-lactoyl-CoA + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61996"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
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            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
            <dbReference type="ChEBI" id="CHEBI:231528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:61997"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
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            <dbReference type="ChEBI" id="CHEBI:61930"/>
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        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
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            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
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        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:45949"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012743674.2"/>
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        <property type="gene ID" value="ENSMICG00000009148.3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
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                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
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    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="10">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00079494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015381.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="133" mass="15133" checksum="6B02E512B2DB1C67" modified="2022-01-19" version="1">MEEDQELERKISGLKTSMAEGERKTALEMVQAAGTDRHCVTFVLHEEDHTLGNSLRYMIMKNPEVEFCGYTTTHPSESKINLRIQTRGALPAVEPFQRGLTELMNVCQHVLDKFEASIKDYKDQKASRSESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F013</accession>
    <name>A0A8B7F013_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CSNK1G2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03027998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601118.1">
        <property type="nucleotide sequence ID" value="XM_012745664.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F013"/>
    <dbReference type="Ensembl" id="ENSMICT00000058339.1">
        <property type="protein sequence ID" value="ENSMICP00000041506.1"/>
        <property type="gene ID" value="ENSMICG00000004391.3"/>
    </dbReference>
    <dbReference type="CTD" id="1455"/>
    <dbReference type="GeneTree" id="ENSGT00940000156470"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14126">
        <property type="entry name" value="STKc_CK1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001113">
        <property type="entry name" value="Casein kinase 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000018">
        <property type="entry name" value="Casein kinase I isoform gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022247">
        <property type="entry name" value="Casein_kinase-1_gamma_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12605">
        <property type="entry name" value="CK1gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="46"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="415" mass="47507" checksum="B11953359B023AA3" modified="2022-01-19" version="1">MDFDKKGGKGELEEGRRMSKTGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTAEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHSDLPSQSQIREKVQLHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADDTKCCCFFKRRKRKSMQRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F0Q9</accession>
    <name>A0A8B7F0Q9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Phosphodiesterase</fullName>
            <ecNumber evidence="31">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="primary">PDE2A</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.</text>
    </comment>
    <comment type="function">
        <text evidence="25">cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16958"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:14654"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="31">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="31">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="27">Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="31"/>
    <dbReference type="EMBL" id="ABDC03006485">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600527.1">
        <property type="nucleotide sequence ID" value="XM_012745073.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F0Q9"/>
    <dbReference type="Ensembl" id="ENSMICT00000050141.2">
        <property type="protein sequence ID" value="ENSMICP00000028455.1"/>
        <property type="gene ID" value="ENSMICG00000012366.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860371"/>
    <dbReference type="KEGG" id="mmur:105860371"/>
    <dbReference type="CTD" id="5138"/>
    <dbReference type="GeneTree" id="ENSGT00940000159817"/>
    <dbReference type="OrthoDB" id="295473at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005741">
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004118">
        <property type="term" value="F:3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
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    <dbReference type="GO" id="GO:0047555">
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    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
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    <dbReference type="GO" id="GO:0030553">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="term" value="F:phosphate ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030911">
        <property type="term" value="F:TPR domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904613">
        <property type="term" value="P:cellular response to 2,3,7,8-tetrachlorodibenzodioxine"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071321">
        <property type="term" value="P:cellular response to cGMP"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036006">
        <property type="term" value="P:cellular response to macrophage colony-stimulating factor stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046069">
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    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106072">
        <property type="term" value="P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043116">
        <property type="term" value="P:negative regulation of vascular permeability"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043117">
        <property type="term" value="P:positive regulation of vascular permeability"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010752">
        <property type="term" value="P:regulation of cGMP-mediated signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000009">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000007">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000014">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="21" id="KW-0114">cAMP</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0140">cGMP</keyword>
    <keyword evidence="18" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 31" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 30 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDEase" evidence="33">
        <location>
            <begin position="575"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="32">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="28">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <begin position="653"/>
            <end position="657"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="693"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="694"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="805"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="856"/>
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        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058327"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="938" mass="105180" checksum="F86E777F2E3C1EA7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F3D4</accession>
    <name>A0A8B7F3D4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adhesion G protein-coupled receptor A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ADGRA1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019418">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602446.1">
        <property type="nucleotide sequence ID" value="XM_012746992.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602447.1">
        <property type="nucleotide sequence ID" value="XM_012746993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F3D4"/>
    <dbReference type="Ensembl" id="ENSMICT00000029690.2">
        <property type="protein sequence ID" value="ENSMICP00000033994.1"/>
        <property type="gene ID" value="ENSMICG00000028134.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105861494"/>
    <dbReference type="CTD" id="84435"/>
    <dbReference type="GeneTree" id="ENSGT00940000160175"/>
    <dbReference type="OrthoDB" id="10031018at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051963">
        <property type="entry name" value="Adhesion_GPCR_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930:SF3">
        <property type="entry name" value="ADHESION G PROTEIN-COUPLED RECEPTOR A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45930">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 124-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="9">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="552" mass="60069" checksum="B22DD5C977395A03" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6D2</accession>
    <name>A0A8B7F6D2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">B9 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">B9D1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the B9D family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603325.1">
        <property type="nucleotide sequence ID" value="XM_012747871.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6D2"/>
    <dbReference type="Ensembl" id="ENSMICT00000046541.2">
        <property type="protein sequence ID" value="ENSMICP00000038600.1"/>
        <property type="gene ID" value="ENSMICG00000014953.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861949"/>
    <dbReference type="KEGG" id="mmur:105861949"/>
    <dbReference type="CTD" id="27077"/>
    <dbReference type="GeneTree" id="ENSGT00940000160079"/>
    <dbReference type="OrthoDB" id="431939at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010796">
        <property type="entry name" value="C2_B9-type_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968">
        <property type="entry name" value="B9 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12968:SF1">
        <property type="entry name" value="B9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07162">
        <property type="entry name" value="B9-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51381">
        <property type="entry name" value="C2_B9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="22662" checksum="99B1AE78DA5FE9DA" modified="2022-01-19" version="1">MAAAGPSVFLLMVNGQVESAQFPEFDNLYCKYCFVYGQDWAPTAGLEEGISQITSKSRDACQALVWNFPIDITFKSTNPFGWPQIVLSVYGPDVFGNDVVRGYGAVHVPFSPGRHKRTIPMFVPESTSKLQKFTSWFMGRRPEYTDPKVVAQGEGREVTRVRSQGFVTLFFNVVTKDMRKLGYNSRPADTQSDPGPSMPQGTPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6Y9</accession>
    <name>A0A8B7F6Y9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptide chain release factor 1-like, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial translational release factor 1-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MTRF1L</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603602.1">
        <property type="nucleotide sequence ID" value="XM_012748148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6Y9"/>
    <dbReference type="Ensembl" id="ENSMICT00000003808.3">
        <property type="protein sequence ID" value="ENSMICP00000003472.3"/>
        <property type="gene ID" value="ENSMICG00000003811.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862107"/>
    <dbReference type="KEGG" id="mmur:105862107"/>
    <dbReference type="CTD" id="54516"/>
    <dbReference type="GeneTree" id="ENSGT00940000155683"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070126">
        <property type="term" value="P:mitochondrial translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1660:FF:000011">
        <property type="entry name" value="Peptide chain release factor 1-like, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001859">
        <property type="entry name" value="PRK00591.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF3">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR 1-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="12">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003472.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="380" mass="43492" checksum="AB8AA2FD608FD039" modified="2022-01-19" version="1">MRPWRLWAAARCLWARPAVGPARRPLSCGSPQLEELFSSGGPLRTFLERQAGSEAQLQVRRPELVTVAKRLSEKEQELRETEHLLHDKNEDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGGQEAMLFTSEIFEMYQQYAAFKRWNFETLEYFPSETGGLRHASASIGGSEAYKHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNKTDSAVRIVHLPTGVVSECQQERSQLKNREMAMKKLRAKLYSMHLEEETSKRYNARKIQVGTKGRSEKIRTYNFPQNRVTDHRINKSLHDLETFMQGDYLLDELVQSLKDYADYESLVEIISQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FAU1</accession>
    <name>A0A8B7FAU1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA-binding motif protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RBM10</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. May be involved in post-transcriptional processing, most probably in mRNA splicing. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A). May bind to specific miRNA hairpins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the spliceosome. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03036530">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605164.1">
        <property type="nucleotide sequence ID" value="XM_012749710.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FAU1"/>
    <dbReference type="Ensembl" id="ENSMICT00000048421.2">
        <property type="protein sequence ID" value="ENSMICP00000032912.2"/>
        <property type="gene ID" value="ENSMICG00000016937.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862993"/>
    <dbReference type="CTD" id="8241"/>
    <dbReference type="GeneTree" id="ENSGT00940000160369"/>
    <dbReference type="OrthoDB" id="29221at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16167">
        <property type="entry name" value="OCRE_RBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12754">
        <property type="entry name" value="RRM2_RBM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000110">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000114">
        <property type="entry name" value="RNA-binding protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000005">
        <property type="entry name" value="RNA-binding protein 10 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035618">
        <property type="entry name" value="RBM10_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034992">
        <property type="entry name" value="RBM10_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="37"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="18">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="223"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="17">
        <location>
            <begin position="781"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="543"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="741"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065703"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067853"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075688"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032912.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="853" mass="94349" checksum="B61E0BEA411894AC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FF54</accession>
    <name>A0A8B7FF54_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Proton-coupled zinc antiporter SLC30A8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 30 member 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Zinc transporter 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC30A8</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606563.1">
        <property type="nucleotide sequence ID" value="XM_012751109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FF54"/>
    <dbReference type="Ensembl" id="ENSMICT00000010557.3">
        <property type="protein sequence ID" value="ENSMICP00000009613.3"/>
        <property type="gene ID" value="ENSMICG00000010560.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863699"/>
    <dbReference type="KEGG" id="mmur:105863699"/>
    <dbReference type="CTD" id="169026"/>
    <dbReference type="GeneTree" id="ENSGT00940000160706"/>
    <dbReference type="OMA" id="RATKMYA"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030667">
        <property type="term" value="C:secretory granule membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140826">
        <property type="term" value="F:zinc:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030070">
        <property type="term" value="P:insulin processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062111">
        <property type="term" value="P:zinc ion import into organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000002">
        <property type="entry name" value="zinc transporter 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF37">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="22">
        <location>
            <begin position="76"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="23">
        <location>
            <begin position="279"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009613.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="369" mass="40913" checksum="4E2A93ED584341D0" modified="2022-01-19" version="1">MEFLERTYLVNDKGTRMYAFTLDSVELQQKPVNKDQRPGERPEELESGGIHHCHSDCRITDNRENEQARAKWKLCAASAICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSKRLTFGWHRAEIFGALLSILCIWVVTGVLVYLACQRLLHPDYQIQATVMIIVSACAVAANVVLAMVLHQRCFGHNHKEVQHNASVRAAFVHALGDLFQSISVLISALIIYFKPDYKIADPICTFIFSILVLASTVTILKDFSILLMEGVPKGLNYDGVKELILAVDGVVSVHSLHIWSLTMNQVILSAHVATAASQDGNVVRREIARALSKSFTVHSLTIQMESQADQDPDCLFCEEPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FGH4</accession>
    <name>A0A8B7FGH4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Crystallin gamma A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CRYGA</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FGH4"/>
    <dbReference type="Ensembl" id="ENSMICT00000063125.1">
        <property type="protein sequence ID" value="ENSMICP00000048005.1"/>
        <property type="gene ID" value="ENSMICG00000045154.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105864303"/>
    <dbReference type="KEGG" id="mmur:105864303"/>
    <dbReference type="GeneTree" id="ENSGT00940000156190"/>
    <dbReference type="OMA" id="HEIHSLH"/>
    <dbReference type="OrthoDB" id="8407241at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF123">
        <property type="entry name" value="GAMMA-CRYSTALLIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="174" mass="21029" checksum="16C7DA989D2664AB" modified="2022-01-19" version="1">MGKITFYEERGFQGRCYECISDCPNLQAYFSRCNSIRVDSGSWMLYERTNYQGHQYLLRRGEYPDYQQWMGLSDSIRSCHRIPYTSSHRLRLYERDNYRGLVSELTEDCSCIQDRFRVHEIHSLHVLEGCWVLYELPNYRGRQYLLRPGDYRRYHDWGAMDAKVGSLRRIIDMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FJQ9</accession>
    <name>A0A8B7FJQ9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomerase associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TEP1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004435">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608276.1">
        <property type="nucleotide sequence ID" value="XM_012752822.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012752823.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000023781.1"/>
        <property type="gene ID" value="ENSMICG00000001497.3"/>
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    <dbReference type="CTD" id="7011"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="TELOMERASE PROTEIN COMPONENT 1"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
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        <location>
            <begin position="183"/>
            <end position="633"/>
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            <begin position="1119"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FKX6</accession>
    <name>A0A8B7FKX6_MICMU</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DSCC1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
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            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA clamp loader activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
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        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
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        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017682"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="393" mass="44935" checksum="E3C2C45E384C2668" modified="2022-01-19" version="1">MRRTREEVDATLQIAKLNAAELLPAVHCLRFGAGASGAAAGDFCLLELEPALCQQLEAGHSLVIRGDKDEPAVLCSKDKTYDLKIADTSNMLLFIPDCKTPDQLKKEEAHCNIIHTEIFGFSNNYWELRRCRPKLKKLKKLLMENTYEGPDSQKEKDSNCSKYTTEDLLDQIQASEEEIMTQLQVLNACEIGGYWRILEFDYEMKLLNHVTQLVDSESWSFGKVPLNICLQELGPLEPEEMIEHCLKCYGNKYTDEGEVYFELSADKICRATAQMLLQNAVKFNLAEFQEVWQQSVPEGMITRLDQLKGLALVDRHSRPEIIFLLKVDDLPEDNQERFNSLFSLREKWTEEDIAPYIQDLCGEKQTIGALLTKYSRSSMQNGVKVYNSRRPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FM87</accession>
    <name>A0A8B7FM87_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">TBC1 domain family member 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TBC1D17</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
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            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with OPTN; this interaction mediates TBC1D17 transient association with Rab8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609776.1">
        <property type="nucleotide sequence ID" value="XM_012754322.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FM87"/>
    <dbReference type="Ensembl" id="ENSMICT00000027155.2">
        <property type="protein sequence ID" value="ENSMICP00000022045.1"/>
        <property type="gene ID" value="ENSMICG00000003129.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000062011.1">
        <property type="protein sequence ID" value="ENSMICP00000047289.1"/>
        <property type="gene ID" value="ENSMICG00000003129.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865620"/>
    <dbReference type="KEGG" id="mmur:105865620"/>
    <dbReference type="CTD" id="79735"/>
    <dbReference type="GeneTree" id="ENSGT00940000158989"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000036">
        <property type="entry name" value="TBC1 domain family member 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF360">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="14">
        <location>
            <begin position="310"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="640"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063386"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067478"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022045.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="650" mass="73036" checksum="D6DA764756546448" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FWA8</accession>
    <name>A0A8B7FWA8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 470</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May be involved in transcriptional regulation. May have a role in embryonic development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613229.1">
        <property type="nucleotide sequence ID" value="XM_012757775.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613230.1">
        <property type="nucleotide sequence ID" value="XM_012757776.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613231.1">
        <property type="nucleotide sequence ID" value="XM_012757777.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139059.1">
        <property type="nucleotide sequence ID" value="XM_020283470.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FWA8"/>
    <dbReference type="Ensembl" id="ENSMICT00000070902.1">
        <property type="protein sequence ID" value="ENSMICP00000044740.1"/>
        <property type="gene ID" value="ENSMICG00000027019.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105867566"/>
    <dbReference type="KEGG" id="mmur:105867566"/>
    <dbReference type="CTD" id="388566"/>
    <dbReference type="GeneTree" id="ENSGT00940000163087"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003729">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001502">
        <property type="entry name" value="ZFP28 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000002">
        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000519">
        <property type="entry name" value="Zinc finger protein 470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000238">
        <property type="entry name" value="Zinc finger protein 485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000070">
        <property type="entry name" value="zinc finger protein 689 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="701" mass="81020" checksum="044E9C8429654E60" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G2J0</accession>
    <name>A0A8B7G2J0_MICMU</name>
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        <recommendedName>
            <fullName evidence="13">Trem-like transcript 2 protein</fullName>
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        <alternativeName>
            <fullName evidence="14">Triggering receptor expressed on myeloid cells-like protein 2</fullName>
        </alternativeName>
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        <name evidence="19" type="primary">TREML2</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.</text>
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    <comment type="subunit">
        <text evidence="12">Interacts with CD276 and this interaction enhances T-cell activation.</text>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012760819.1"/>
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        <property type="nucleotide sequence ID" value="XM_012760820.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000019621.1"/>
        <property type="gene ID" value="ENSMICG00000027522.2"/>
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    <dbReference type="CTD" id="79865"/>
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        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:T cell activation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Triggering receptor expressed on myeloid cells like 2"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Immune_rcpt_domain"/>
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        <property type="entry name" value="TREM-LIKE TRANSCRIPT 2 PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR16423">
        <property type="entry name" value="TREM-LIKE TRANSCRIPT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133758" description="Trem-like transcript 2 protein" evidence="17">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
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        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="21"/>
            <end position="105"/>
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    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="189"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="221"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
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            <begin position="300"/>
            <end position="314"/>
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            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059754"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066031"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071543"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00082751"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019621.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="324" mass="35097" checksum="7ACB6FF63432A609" modified="2022-01-19" version="1">MPPATLLLLLLWLQGCVSGLPAESAYTKVKLLEGETLSVQCSYKGYKNRVEGKVWCKIRRKRCEPGFTRAWVKGPRYLLQDDAQVKVVNITMVALKSQDSGRYWCMRNTSGTLYPLMGIQLEVSPGSAAERSTPLTHLADVFKSGIVAAGQAPSSGPDVPSATGRTGFTPGILTLARLLPSSSPTSMPGYSFTGASLTTTGPRRTAGGQTATAPPRNAGASSVGSESISSESGHLGTRVPVTVMCHTSRSLDKFPSLRNQDFYPTVLVMGLTFLLVPVMLVVVYGLWKKRHVGSYSIRSDPARPWKDPPRRPEPPWKLAWSETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G4V3</accession>
    <name>A0A8B7G4V3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Family with sequence similarity 114 member A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FAM114A2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM114 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027486">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617220.2">
        <property type="nucleotide sequence ID" value="XM_012761766.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139277.1">
        <property type="nucleotide sequence ID" value="XM_020283688.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_020283689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G4V3"/>
    <dbReference type="Ensembl" id="ENSMICT00000003553.3">
        <property type="protein sequence ID" value="ENSMICP00000003233.3"/>
        <property type="gene ID" value="ENSMICG00000003553.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869730"/>
    <dbReference type="KEGG" id="mmur:105869730"/>
    <dbReference type="CTD" id="10827"/>
    <dbReference type="GeneTree" id="ENSGT00390000010054"/>
    <dbReference type="OrthoDB" id="5597648at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007998">
        <property type="entry name" value="DUF719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842">
        <property type="entry name" value="FI01459P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12842:SF3">
        <property type="entry name" value="PROTEIN FAM114A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05334">
        <property type="entry name" value="DUF719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003233.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="511" mass="56031" checksum="0A0BDE4D357359EC" modified="2022-01-19" version="1">MSDKDDSETPVLTEAVPILEDGNCEPAKNSESVDQNAKPESKSEPIASTRKRPEAKPSSDLETSEVLPVPVSQAPGKETVSKDVPQTGWGYWGSWGKSLLSSASATVATVGQGISTVIEKAETSLGIPSPSEVSTEQYAAGEINTKDNENSSPMAGPFGVFSTISTAVQSTGKSVISGGLDALEFIGKKTMDVIAEGDPGFKRTKGLMNRNSTLSQVLREAKEKEELRTSDEVTMETEKKTHYGLLFDEFQGLSHLEALEMLSRESEIKVKSILNSLSGEELETLKLELQQLKEAFSLAEFCEEEEEEKIGDEDFTKEITELFSQLHVSSKPEKLAKARNTAHEWIRTSLTKPFTEQEEGEKLLEAENNEQVNKNSIEDIHAFAIRSLAELTACSIELFHKTAALVLHGRKQEVTAIERSRTLSQMTVVLCKELSSLSKEFTTCLTTAGVKEKADVLNPLITAVFLEASNSASYIQDAFQLLLPVLEISLIENKTESPQHELQSQRPLSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GB93</accession>
    <name>A0A8B7GB93_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fibrosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FBRS</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619661.1">
        <property type="nucleotide sequence ID" value="XM_012764207.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GB93"/>
    <dbReference type="Ensembl" id="ENSMICT00000040253.2">
        <property type="protein sequence ID" value="ENSMICP00000033436.1"/>
        <property type="gene ID" value="ENSMICG00000034982.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871073"/>
    <dbReference type="KEGG" id="mmur:105871073"/>
    <dbReference type="CTD" id="64319"/>
    <dbReference type="GeneTree" id="ENSGT00940000161032"/>
    <dbReference type="OrthoDB" id="10060000at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023246">
        <property type="entry name" value="AUTS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429:SF24">
        <property type="entry name" value="FIBROSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14429">
        <property type="entry name" value="FIBROSIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15336">
        <property type="entry name" value="Auts2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02044">
        <property type="entry name" value="FIBROSIN1LPF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="925"/>
            <end position="981"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
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        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
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            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="282"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="386"/>
        </location>
    </feature>
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        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="767"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="830"/>
        </location>
    </feature>
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        <location>
            <begin position="957"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="981" mass="103589" checksum="444DC5781AF535E1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GEQ8</accession>
    <name>A0A8B7GEQ8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Syncoilin, intermediate filament protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SYNC</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="EMBL" id="ABDC03001609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000035006.2"/>
        <property type="gene ID" value="ENSMICG00000033792.2"/>
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        <property type="entry name" value="SYNCOILIN"/>
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        <property type="entry name" value="SYNCOILIN"/>
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    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Filament"/>
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    <keyword evidence="1" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="171"/>
            <end position="466"/>
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            <begin position="1"/>
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    <evidence type="ECO:0000256" key="4">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GNM7</accession>
    <name>A0A8B7GNM7_MICMU</name>
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        <recommendedName>
            <fullName evidence="15">Endophilin-A2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endophilin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SH3GL1</name>
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    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Implicated in endocytosis. May recruit other proteins to membranes with high curvature.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the endophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028042">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624719.1">
        <property type="nucleotide sequence ID" value="XM_012769265.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GNM7"/>
    <dbReference type="Ensembl" id="ENSMICT00000035386.2">
        <property type="protein sequence ID" value="ENSMICP00000028604.1"/>
        <property type="gene ID" value="ENSMICG00000000322.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873927"/>
    <dbReference type="KEGG" id="mmur:105873927"/>
    <dbReference type="CTD" id="6455"/>
    <dbReference type="GeneTree" id="ENSGT00940000154737"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016191">
        <property type="term" value="P:synaptic vesicle uncoating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="BAR_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11803">
        <property type="entry name" value="SH3_Endophilin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="endophilin-A1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000021">
        <property type="entry name" value="Endophilin-A2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035824">
        <property type="entry name" value="Endophilin_A_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF63">
        <property type="entry name" value="ENDOPHILIN-A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10 18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="21">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="306"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="243"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="368" mass="41552" checksum="07BCB3A155303903" modified="2022-01-19" version="1">MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLTRTIEYLQPNPASRAKLTMLNTVSKIRGQVKSPGYPQPEGLLGECMIRHGKELGGESNFGDALLDAGESMKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGRIPDEELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELADKLKRRMRDTSSRPKREYKPKPREPFDLGEPEQSNGGFPCATAPKITASSSFRSSDKPIRTPSRSMPPLDQPSCKALYDFEPENDGELGFREGDVITLTNQIDENWYEGMLDGQSGFFPLSYVEVLVPLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GQN7</accession>
    <name>A0A8B7GQN7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Reversion-inducing cysteine-rich protein with Kazal motifs</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RECK</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity. Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP).</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts (via knot repeats) with WNT7A (via disordered linker region); the interaction is direct. Interacts (via knot repeats) with WNT7B (via disordered linker region); the interaction is direct. Interacts with ADGRA2; the interaction is direct. Interacts with MMP9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RECK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625419.1">
        <property type="nucleotide sequence ID" value="XM_012769965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GQN7"/>
    <dbReference type="Ensembl" id="ENSMICT00000063899.1">
        <property type="protein sequence ID" value="ENSMICP00000046148.1"/>
        <property type="gene ID" value="ENSMICG00000045799.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105874290"/>
    <dbReference type="KEGG" id="mmur:105874290"/>
    <dbReference type="CTD" id="8434"/>
    <dbReference type="GeneTree" id="ENSGT00390000018540"/>
    <dbReference type="OrthoDB" id="5956770at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990909">
        <property type="term" value="C:Wnt signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001955">
        <property type="term" value="P:blood vessel maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010716">
        <property type="term" value="P:negative regulation of extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045765">
        <property type="term" value="P:regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090210">
        <property type="term" value="P:regulation of establishment of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002040">
        <property type="term" value="P:sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000011">
        <property type="entry name" value="reversion-inducing cysteine-rich protein with Kazal motifs isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000021">
        <property type="entry name" value="reversion-inducing cysteine-rich protein with Kazal motifs isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056978">
        <property type="entry name" value="CC4_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056976">
        <property type="entry name" value="EGF1_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055134">
        <property type="entry name" value="EGF2_RECK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056977">
        <property type="entry name" value="FnI_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056979">
        <property type="entry name" value="FZ_RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039016">
        <property type="entry name" value="RECK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055110">
        <property type="entry name" value="RECK-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487:SF3">
        <property type="entry name" value="REVERSION-INDUCING CYSTEINE-RICH PROTEIN WITH KAZAL MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13487">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23332">
        <property type="entry name" value="CC4_RECK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25027">
        <property type="entry name" value="EGF1_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22955">
        <property type="entry name" value="EGF2_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25028">
        <property type="entry name" value="FnI_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23298">
        <property type="entry name" value="FZ_RECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22961">
        <property type="entry name" value="RECK-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133925" description="Reversion-inducing cysteine-rich protein with Kazal motifs" evidence="17">
        <location>
            <begin position="23"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="627"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="698"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="971" mass="106330" checksum="36E5508D28ACFD96" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H441</accession>
    <name>A0A8B7H441_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of very long chain fatty acids protein 7</fullName>
            <ecNumber evidence="10">2.3.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-keto acyl-CoA synthase ELOVL7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">ELOVL fatty acid elongase 7</fullName>
            <shortName evidence="10">ELOVL FA elongase 7</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Very long chain 3-ketoacyl-CoA synthase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Very long chain 3-oxoacyl-CoA synthase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">ELOVL7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family. ELOVL7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03016543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631089.1">
        <property type="nucleotide sequence ID" value="XM_012775635.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631090.1">
        <property type="nucleotide sequence ID" value="XM_012775636.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631093.1">
        <property type="nucleotide sequence ID" value="XM_012775639.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H441"/>
    <dbReference type="Ensembl" id="ENSMICT00000061097.1">
        <property type="protein sequence ID" value="ENSMICP00000041134.1"/>
        <property type="gene ID" value="ENSMICG00000042937.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105877264"/>
    <dbReference type="KEGG" id="mmur:105877264"/>
    <dbReference type="CTD" id="79993"/>
    <dbReference type="GeneTree" id="ENSGT01050000244838"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035338">
        <property type="term" value="P:long-chain fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03207">
        <property type="entry name" value="VLCF_elongase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033670">
        <property type="entry name" value="ELOVL7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF118">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10 11">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="281" mass="33584" checksum="FEE4BD8BCB78D9F5" modified="2022-01-19" version="1">MAFSDLTSRTVRLYDNWIKDADPRVEDWLLMSSPLPQTIILGLYVYFVTSLGPKLMENRKPFELKRAMITYNFFIVLFSVYMCYEFVMSGWGTGYSFRCEIVDYSRSPTALRMARTCWLYYFSKFIELLDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHAFLNTAVHVVMYTYYGICALGPAYQKYLWWKKYLTSLQLVQFIIVTIHIGQFFFMEDCKYQFPVFLYIIMSYGCIFLLLFLHFWYRAYTKGQRLPKTVKNGNYRNKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H7N4</accession>
    <name>A0A8B7H7N4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="17">1.3.8.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="primary">ACADVL</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a very-long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:19181"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.8.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:19182"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>docosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-docosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47228"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65059"/>
            <dbReference type="ChEBI" id="CHEBI:74692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:47229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dodecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-dodecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:47297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>eicosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-eicosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:74691"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:47237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octadecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-octadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:47241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>oxidized [electron-transfer flavoprotein] + hexadecanoyl-CoA + H(+) = (2E)-hexadecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:43449"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>tetracosanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetracosenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:74693"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47233"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>tetradecanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-tetradecenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:47316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:47317"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 29">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Homodimerizes after import into the mitochondrion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 29">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.9" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03020560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632557.1">
        <property type="nucleotide sequence ID" value="XM_012777103.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H7N4"/>
    <dbReference type="Ensembl" id="ENSMICT00000070665.1">
        <property type="protein sequence ID" value="ENSMICP00000044801.1"/>
        <property type="gene ID" value="ENSMICG00000004298.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877978"/>
    <dbReference type="CTD" id="37"/>
    <dbReference type="GeneTree" id="ENSGT00940000158535"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004466">
        <property type="term" value="F:long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017099">
        <property type="term" value="F:very-long-chain fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01161">
        <property type="entry name" value="VLCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000008">
        <property type="entry name" value="acyl-CoA dehydrogenase family member 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000017">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000006">
        <property type="entry name" value="very long-chain specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000001">
        <property type="entry name" value="Very long-chain-specific acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049448">
        <property type="entry name" value="ACAD9/ACADV-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF11">
        <property type="entry name" value="VERY LONG-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21343">
        <property type="entry name" value="ACAD9-ACADV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 29" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 29" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13 29" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="32">
        <location>
            <begin position="104"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="31">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="30">
        <location>
            <begin position="327"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="ACAD9/ACADV-like C-terminal" evidence="33">
        <location>
            <begin position="527"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00049050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF21343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="655" mass="70302" checksum="F927FD3A919C826F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H7R5</accession>
    <name>A0A8B7H7R5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 family 27 subfamily B member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">CYP27B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632585.1">
        <property type="nucleotide sequence ID" value="XM_012777131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H7R5"/>
    <dbReference type="Ensembl" id="ENSMICT00000032020.2">
        <property type="protein sequence ID" value="ENSMICP00000034566.1"/>
        <property type="gene ID" value="ENSMICG00000037335.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105877998"/>
    <dbReference type="KEGG" id="mmur:105877998"/>
    <dbReference type="CTD" id="1594"/>
    <dbReference type="VGNC" id="VGNC:80524">
        <property type="gene designation" value="CYP27B1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182905"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004498">
        <property type="term" value="F:calcidiol 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062185">
        <property type="term" value="F:secalciferol 1-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006700">
        <property type="term" value="P:C21-steroid hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071305">
        <property type="term" value="P:cellular response to vitamin D"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046697">
        <property type="term" value="P:decidualization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070314">
        <property type="term" value="P:G1 to G0 transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006704">
        <property type="term" value="P:glucocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045618">
        <property type="term" value="P:positive regulation of keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070564">
        <property type="term" value="P:positive regulation of vitamin D receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042369">
        <property type="term" value="P:vitamin D catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20648">
        <property type="entry name" value="CYP27B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000006">
        <property type="entry name" value="Cytochrome P450 302a1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF121">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 27 SUBFAMILY B MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="VGNC" id="VGNC:80524"/>
        </source>
    </evidence>
    <sequence length="508" mass="56199" checksum="FBE3EF51F9B08AC5" modified="2022-01-19" version="1">MTQALKFAARVFHRGRCAPELGASRDYRNYDSAPRGLADIPGPSTPSFLAELFCKGGLSRLHELQVQGAARFGPVWLASFGTVRTVYVAAPALIEQLLRQEGPRPERCSFSPWVEHRRHRQRACGLLTAEGEEWQRLRSLLAPLLLRPHAAAGYAGTLDSVVCDLVRRLRRQRGRGTGPPSLVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAEVPPDTEGFIRAVGSVFVSTLLTMAMPSWLQRLVPGPWGRLCRDWDQMFAFAQQHVERREAEVAMRNRGKSEEDVGPGAYLTYFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALGHGSSAHPPATALSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEDPAPHPFASLPFGFGKRSCIGRRLAELELQMALAQILTHFEVQPEPGAAPIRPMTRTVLVPERSINLQFVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H971</accession>
    <name>A0A8B7H971_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box only protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">FBXO4</name>
        <name evidence="10" type="synonym">RIMOC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of cyclin-D1 (CCND1) and its subsequent proteasomal degradation. However, it does not act as a major regulator of CCND1 stability during the G1/S transition. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO4) formed of CUL1, SKP1, RBX1 and FBXO4. Interacts with TERF1; this interaction is prevented in the presence of GNL3L. Identified in a complex with CRYAB and CCND1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03016474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633227.1">
        <property type="nucleotide sequence ID" value="XM_012777773.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H971"/>
    <dbReference type="Ensembl" id="ENSMICT00000049276.2">
        <property type="protein sequence ID" value="ENSMICP00000023917.1"/>
        <property type="gene ID" value="ENSMICG00000006133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878383"/>
    <dbReference type="KEGG" id="mmur:105878383"/>
    <dbReference type="CTD" id="26272"/>
    <dbReference type="GeneTree" id="ENSGT00390000014416"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019725">
        <property type="term" value="P:cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035726">
        <property type="term" value="P:common myeloid progenitor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048147">
        <property type="term" value="P:negative regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900181">
        <property type="term" value="P:negative regulation of protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902916">
        <property type="term" value="P:positive regulation of protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032212">
        <property type="term" value="P:positive regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031648">
        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000001">
        <property type="term" value="P:regulation of DNA damage checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22085">
        <property type="entry name" value="F-box_FBXO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11656">
        <property type="entry name" value="FBX4_GTPase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001110">
        <property type="entry name" value="F-box only protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000020">
        <property type="entry name" value="F-box only protein 4 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039588">
        <property type="entry name" value="FBXO4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16008:SF4">
        <property type="entry name" value="F-BOX ONLY PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="9">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="387" mass="44184" checksum="E51FCF3EB8AA681A" modified="2022-01-19" version="1">MAGSEPRSGTSYSPPPPSDWSRLEAAILSGWRTFWQSVGKERPTQRAPREEADEAASTLTRLPIDIQLYILSFLSPHDLCQLGRTNHYWNETVRDPILWRYFLLRDFPSWSSVDWKSLPDLEILKKPISEVTDGAFFDYMAVYKTCCPYTRRALKSSRPMYGAVTSFLHSLIIQNEPRFAMFGPGLEELNTSLVLSLMSSEELCPMAGLPQRQIDGIGSGVNFQLSNQHKFNILILYSTTRKERDRAREEHTSAVNKMFSLQNEGDDQQGSRYSVIPQIQKVCEVVDGFIYVANAEAHKRHDWKDELSHIMAMTDPAFGSSGRPMLVLSCISKADVKRMPCFYLAHELRLNLLNHPWMVQDTEAETLSGFLNGIEWILEEVESKHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HGK7</accession>
    <name>A0A8B7HGK7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cAMP-dependent protein kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PKIG</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the PKI family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636235.1">
        <property type="nucleotide sequence ID" value="XM_012780781.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636251.1">
        <property type="nucleotide sequence ID" value="XM_012780797.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636256.1">
        <property type="nucleotide sequence ID" value="XM_012780802.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636266.1">
        <property type="nucleotide sequence ID" value="XM_012780812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HGK7"/>
    <dbReference type="Ensembl" id="ENSMICT00000066110.1">
        <property type="protein sequence ID" value="ENSMICP00000044109.1"/>
        <property type="gene ID" value="ENSMICG00000044432.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105880024"/>
    <dbReference type="KEGG" id="mmur:105880024"/>
    <dbReference type="CTD" id="11142"/>
    <dbReference type="GeneTree" id="ENSGT00390000002707"/>
    <dbReference type="OMA" id="TRDSHIF"/>
    <dbReference type="OrthoDB" id="8556393at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042308">
        <property type="term" value="P:negative regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004171">
        <property type="entry name" value="cAMP_dep_PKI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15416">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE INHIBITOR/PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02827">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001667">
        <property type="entry name" value="PKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="site" description="Important for inhibition" evidence="5">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="site" description="Important for inhibition" evidence="5">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="site" description="Important for inhibition" evidence="5">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001667-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="76" mass="7960" checksum="871B328EBDB3FE59" modified="2022-01-19" version="1">MMEVESSYSDFISCDRTGRRNAVPDIQGDSEAVSVRKLAGDMSELALEGTEGQAEASTADKEASNQPQSSDGATSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HGU1</accession>
    <name>A0A8B7HGU1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SR-related CTD associated factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SCAF4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012780918.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000018371.2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
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        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="1"/>
            <end position="139"/>
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        <location>
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            <end position="580"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <feature type="region of interest" description="Disordered" evidence="8">
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    <sequence length="1142" mass="125527" checksum="BCFB7355E95E91B8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HHD3</accession>
    <name>A0A8B7HHD3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Molecular chaperone MKKS</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MKKS</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of a complex composed at least of MKKS, BBS10, BBS12, TCP1, CCT2, CCT3, CCT4, CCT5 and CCT8. Interacts with STUB1. Interacts with BBS2 (via coiled coil domain). Interacts with CCDC28B. Interacts with BBS12. Interacts with SMARCC1, a component of the SWI/SNF complexes; the interaction takes place predominantly in the cytoplasm and may modulate SMARCC1 location. Interacts with DLEC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012780820.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000058441.1">
        <property type="protein sequence ID" value="ENSMICP00000042835.1"/>
        <property type="gene ID" value="ENSMICG00000043988.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061875.1">
        <property type="protein sequence ID" value="ENSMICP00000044936.1"/>
        <property type="gene ID" value="ENSMICG00000043988.1"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
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        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:kinociliary basal body"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014824">
        <property type="term" value="P:artery smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050910">
        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of sound"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060324">
        <property type="term" value="P:face development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038108">
        <property type="term" value="P:negative regulation of appetite by leptin-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045776">
        <property type="term" value="P:negative regulation of blood pressure"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060296">
        <property type="term" value="P:regulation of cilium beat frequency involved in ciliary motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051492">
        <property type="term" value="P:regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902140">
        <property type="term" value="P:response to inositol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035176">
        <property type="term" value="P:social behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021756">
        <property type="term" value="P:striatum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042311">
        <property type="term" value="P:vasodilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000016">
        <property type="entry name" value="McKusick-Kaufman syndrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000011">
        <property type="entry name" value="McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028790">
        <property type="entry name" value="MKKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46787:SF1">
        <property type="entry name" value="MOLECULAR CHAPERONE MKKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46787">
        <property type="entry name" value="SYNDROMES PUTATIVE CHAPERONIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="569" mass="61682" checksum="2400BA28816A9D53" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HSF6</accession>
    <name>A0A8B7HSF6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NOTCH regulated ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NRARP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Interacts with LEF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRARP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639910.1">
        <property type="nucleotide sequence ID" value="XM_012784456.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HSF6"/>
    <dbReference type="SMR" id="A0A8B7HSF6"/>
    <dbReference type="Ensembl" id="ENSMICT00000008751.3">
        <property type="protein sequence ID" value="ENSMICP00000022265.1"/>
        <property type="gene ID" value="ENSMICG00000008761.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882245"/>
    <dbReference type="KEGG" id="mmur:105882245"/>
    <dbReference type="CTD" id="441478"/>
    <dbReference type="GeneTree" id="ENSGT00940000161928"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019208">
        <property type="term" value="F:phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002043">
        <property type="term" value="P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001569">
        <property type="term" value="P:branching involved in blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045746">
        <property type="term" value="P:negative regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045581">
        <property type="term" value="P:negative regulation of T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905564">
        <property type="term" value="P:positive regulation of vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032525">
        <property type="term" value="P:somite rostral/caudal axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101023">
        <property type="term" value="P:vascular endothelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000085">
        <property type="entry name" value="Notch-regulated ankyrin repeat-containing protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051226">
        <property type="entry name" value="PP1_Regulatory_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179:SF21">
        <property type="entry name" value="MYOSIN BINDING SUBUNIT, ISOFORM O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24179">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="114" mass="12492" checksum="C8B84B648DB47F4F" modified="2022-01-19" version="1">MSQAELSTCSAPQTQRIFQEAVRKGNTQELQSLLQNMTNCEFNVNSFGPEGQTALHQSVIDGNLELVKLLVKFGADIRLANRDGWSALHIAAFGGHQDIVLYLITKAKYAASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I1F7</accession>
    <name>A0A8B7I1F7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium channel subfamily K member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KCNK3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011909">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643640.1">
        <property type="nucleotide sequence ID" value="XM_012788186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I1F7"/>
    <dbReference type="Ensembl" id="ENSMICT00000034691.2">
        <property type="protein sequence ID" value="ENSMICP00000034072.2"/>
        <property type="gene ID" value="ENSMICG00000006852.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884378"/>
    <dbReference type="KEGG" id="mmur:105884378"/>
    <dbReference type="CTD" id="3777"/>
    <dbReference type="GeneTree" id="ENSGT00940000158248"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005252">
        <property type="term" value="F:open rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071468">
        <property type="term" value="P:cellular response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003029">
        <property type="term" value="P:detection of hypoxic conditions in blood by carotid body chemoreceptor signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099605">
        <property type="term" value="P:regulation of action potential firing rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000057">
        <property type="entry name" value="Potassium channel subfamily K member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003092">
        <property type="entry name" value="2pore_dom_K_chnl_TASK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005406">
        <property type="entry name" value="KCNK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF138">
        <property type="entry name" value="POTASSIUM CHANNEL SUBFAMILY K MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038061">
        <property type="entry name" value="K_channel_subfamily_K_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01584">
        <property type="entry name" value="TASK1CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01095">
        <property type="entry name" value="TASKCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9 12 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="6 12" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="15">
        <location>
            <begin position="167"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="394" mass="43705" checksum="B5AAF414D8463A93" modified="2022-01-19" version="1">MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERIVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTFVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTHNGRAGGCGGGGGGSAHTTDTASSPAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGMGGRYSDTPSRRCLCSVAPRSAISSVSTGLHSLSTFRGLMKRRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7IAB9</accession>
    <name>A0A8B7IAB9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylacetamide deacetylase like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AADACL2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000588">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646764.1">
        <property type="nucleotide sequence ID" value="XM_012791310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7IAB9"/>
    <dbReference type="Ensembl" id="ENSMICT00000072760.1">
        <property type="protein sequence ID" value="ENSMICP00000051513.1"/>
        <property type="gene ID" value="ENSMICG00000048956.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105885981"/>
    <dbReference type="KEGG" id="mmur:105885981"/>
    <dbReference type="CTD" id="344752"/>
    <dbReference type="GeneTree" id="ENSGT00940000161405"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017157">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF28">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037251">
        <property type="entry name" value="Arylacetamide_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="107"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="313"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR037251-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="402" mass="46306" checksum="A5E51B00E244D29B" modified="2022-01-19" version="1">MGFKALCLGLLFVLFVSYIYKPIPENVEESWKVLALDVPLKILSLMAIYFEKLGIINYAEFISIIAKLDYTQPHSDEYLTVTDMAFADIPVRLYLPKRKSEIPRRAVIYVHGGAFCFGSFKMRIYDSMNRWTANKLDAVVVSVDYGLAPKHKFPVAFEDVLTAVKFFLQDKILTKYGVDPTRIGVAGDSSGCALLAAVTQQIQNDPEIKHKIKAQVFIYPVLQIIDSFLPSYREYEHGIFLTRDRAVKLVSLYVFGNDEAFYQAIKRNQYMPLESKHLFKFVNWSILLPEKYRKNHVYTEPILGRPGYSFPALMDNRASPLLANDSQLKNLPLTYILTCEYDILRDDGLMFVSRLRNVGVPVTHDHVENGFHAALLFMMPPFYLRLGFRIRDMYNSWLDKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X097</accession>
    <name>A0A8B7X097_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Apoptosis-inducing factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Apoptosis-inducing factor-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AIFM3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012632116.1">
        <property type="nucleotide sequence ID" value="XM_012776662.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632117.1">
        <property type="nucleotide sequence ID" value="XM_012776663.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632118.1">
        <property type="nucleotide sequence ID" value="XM_012776664.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632119.1">
        <property type="nucleotide sequence ID" value="XM_012776665.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632120.1">
        <property type="nucleotide sequence ID" value="XM_012776666.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632122.1">
        <property type="nucleotide sequence ID" value="XM_012776668.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140929.1">
        <property type="nucleotide sequence ID" value="XM_020285340.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X097"/>
    <dbReference type="Ensembl" id="ENSMICT00000069367.1">
        <property type="protein sequence ID" value="ENSMICP00000041804.1"/>
        <property type="gene ID" value="ENSMICG00000014580.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877773"/>
    <dbReference type="KEGG" id="mmur:105877773"/>
    <dbReference type="CTD" id="150209"/>
    <dbReference type="GeneTree" id="ENSGT00940000160448"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000058">
        <property type="entry name" value="apoptosis-inducing factor 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000003">
        <property type="entry name" value="apoptosis-inducing factor 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000011">
        <property type="entry name" value="Apoptosis-inducing factor, mitochondrion-associated, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF8">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="17">
        <location>
            <begin position="70"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="605" mass="66622" checksum="D232ADA8853BD3C9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X8J5</accession>
    <name>A0A8B7X8J5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain containing 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCDC38</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143500.1">
        <property type="nucleotide sequence ID" value="XM_020287911.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X8J5"/>
    <dbReference type="Ensembl" id="ENSMICT00000012154.3">
        <property type="protein sequence ID" value="ENSMICP00000011063.3"/>
        <property type="gene ID" value="ENSMICG00000012156.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877090"/>
    <dbReference type="KEGG" id="mmur:105877090"/>
    <dbReference type="CTD" id="120935"/>
    <dbReference type="GeneTree" id="ENSGT00940000153110"/>
    <dbReference type="OrthoDB" id="10264063at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061827">
        <property type="term" value="C:sperm head"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061649">
        <property type="term" value="F:ubiquitin-modified histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120316">
        <property type="term" value="P:sperm flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051147">
        <property type="entry name" value="CFAP_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025252">
        <property type="entry name" value="DUF4200"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683:SF7">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21683">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 42 LIKE-2-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13863">
        <property type="entry name" value="DUF4200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4200" evidence="6">
        <location>
            <begin position="112"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011063.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="559" mass="65151" checksum="412DE7B43231F540" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XAQ7</accession>
    <name>A0A8B7XAQ7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SMARCA2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592769.2">
        <property type="nucleotide sequence ID" value="XM_012737315.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144867.1">
        <property type="nucleotide sequence ID" value="XM_020289278.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144868.1">
        <property type="nucleotide sequence ID" value="XM_020289279.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144869.1">
        <property type="nucleotide sequence ID" value="XM_020289280.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144870.1">
        <property type="nucleotide sequence ID" value="XM_020289281.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000005173.3">
        <property type="protein sequence ID" value="ENSMICP00000004717.3"/>
        <property type="gene ID" value="ENSMICG00000005162.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855983"/>
    <dbReference type="KEGG" id="mmur:105855983"/>
    <dbReference type="CTD" id="6595"/>
    <dbReference type="GeneTree" id="ENSGT00940000154821"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05516">
        <property type="entry name" value="Bromo_SNF2L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18063">
        <property type="entry name" value="DEXHc_SMARCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000004">
        <property type="entry name" value="probable global transcription activator SNF2L2 isoform X1"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.40.5.120:FF:000001">
        <property type="entry name" value="probable global transcription activator SNF2L2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000089">
        <property type="entry name" value="Putative global transcription activator SNF2L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003020">
        <property type="entry name" value="SNF2-related domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006576">
        <property type="entry name" value="BRK_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037259">
        <property type="entry name" value="BRK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
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    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
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    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
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        <property type="entry name" value="SNF2_N"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF07529">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00951">
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        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF160481">
        <property type="entry name" value="BRK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="10 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="QLQ" evidence="21">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="20">
        <location>
            <begin position="426"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="726"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="1044"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="17">
        <location>
            <begin position="1409"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="95"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="204"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="541"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="617"/>
            <end position="662"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XB07</accession>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Mammalia</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="10">Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines.</text>
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        <property type="entry name" value="MCFD2-like"/>
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        <property type="entry name" value="CELL GROWTH REGULATOR WITH EF HAND DOMAIN PROTEIN 1"/>
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    </dbReference>
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        <property type="entry name" value="MULTIPLE COAGULATION FACTOR DEFICIENCY PROTEIN 2 NEURAL STEM CELL DERIVED NEURONAL SURVIVAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0338">Growth arrest</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="284" mass="30712" checksum="EA177603F417AF58" modified="2022-01-19" version="1">MLPLMMRVLMLLLLPLGQAAPKDGATRLDSEVQHQLLPNPFQPGLEQLRLLQGYLKGLEKMEEEPEHLSWEQVLLYLFALHDYDQSGQLDGLELLSMLTAALAPGVADSPTTNPVVLVVDKVLETQDLNGDGLMTPAELVNFPGEGPRHAEPREPLAPSPREPQAVGRQSLLAKSPLRQEIQEVLDPREAAGGHVEARRESLEPVQEAGGQAEAEGDAPGHGGKAGGQAEAEEDAPGHGGEAESQAEVRDNGEEAKELPGETLELKNTPNEFEVHSIQLENDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJG0</accession>
    <name>A0A8C5UJG0_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 4E type 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">EIF4E3</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. EIF4E3 interacts with EIF4G1, but not with EIF4EBP1, EIF4EBP2 and EIF4EBP3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJG0"/>
    <dbReference type="Ensembl" id="ENSMICT00000001124.3">
        <property type="protein sequence ID" value="ENSMICP00000001022.3"/>
        <property type="gene ID" value="ENSMICG00000001125.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155865"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF66">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00070560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001022.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="187" mass="20788" checksum="BA9D434E1826504A" modified="2022-01-19" version="1">TLGDVFIATGSSGIQPSPGRLLLSLPGATAAQCASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDRAADDEVIGVSVSIRDREDVVQVWNVNASLVGEATVLEKIYELLPHITFKAVFYKPHEEHHAFEGGRGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UMJ7</accession>
    <name>A0A8C5UMJ7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="21">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">GALNT1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:23957"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Golgi apparatus membrane</location>
            <topology evidence="21">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03022874">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03022875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597569.1">
        <property type="nucleotide sequence ID" value="XM_012742115.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UMJ7"/>
    <dbReference type="Ensembl" id="ENSMICT00000003244.3">
        <property type="protein sequence ID" value="ENSMICP00000002943.2"/>
        <property type="gene ID" value="ENSMICG00000003245.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105858764"/>
    <dbReference type="CTD" id="2589"/>
    <dbReference type="GeneTree" id="ENSGT00940000154732"/>
    <dbReference type="OrthoDB" id="330637at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23466">
        <property type="entry name" value="beta-trefoil_Ricin_GALNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000014">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000005">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF123">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 21" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14 21" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 21" id="KW-0430">Lectin</keyword>
    <keyword evidence="18 21" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="23">
        <location>
            <begin position="426"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002943.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="559" mass="64116" checksum="8561BDE891040843" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UMT5</accession>
    <name>A0A8C5UMT5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC105858350</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>eicosanoyl-CoA + H2O = eicosanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40147"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32360"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:40148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:30140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03003872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UMT5"/>
    <dbReference type="Ensembl" id="ENSMICT00000002777.3">
        <property type="protein sequence ID" value="ENSMICP00000002528.3"/>
        <property type="gene ID" value="ENSMICG00000002778.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222336"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF6">
        <property type="entry name" value="PEROXISOMAL SUCCINYL-COENZYME A THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="13">
        <location>
            <begin position="203"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002528.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="421" mass="46328" checksum="1D9BE36BF4D7575C" modified="2022-01-19" version="1">MTATLILEPAGRCCWDEPVRIVVRGLAPEQPVTLRASLRDEKGALFRAHARYRADVAGQLDLARAPALGGSFAGLEPMGLLWALEPQKPLRRFLKRDVRTPFAVELEVLDGHGPEAGRLLGRAVHERDFLPPGVRREPVRADRVRATLFLPPGPGPFPGIIDIFGLGGGLLEYRASLLAGHGFATLALAYYDFEDLPKQLDNIHLEYFEEALCYMLQHPQVKGPGIGLLGISLGADICLSMASFLKNVSATVSINGSVFTGNRGLHYKQTSIPPLGYDLRRTKVAFSGLLDIVDVRNDTVGGCENPSMIPIEKAQGPILFIVGQDDHNWRSELYAQVASERLQAHGKEKPQIISYPGTGHYIEPPYFPLCPASFHILLNKPVMWGGEPRPHSKAQVDAWKQILSFFCKHLGGTQKRAFPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNV9</accession>
    <name>A0A8C5UNV9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">steroid 11beta-monooxygenase</fullName>
            <ecNumber evidence="4">1.14.15.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cytochrome P450C11</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxy-11-deoxycorticosterone + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:76151"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16973"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:195166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:76152"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = corticosterone + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:46104"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16827"/>
            <dbReference type="ChEBI" id="CHEBI:16973"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46105"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a steroid + 2 reduced [adrenodoxin] + O2 + 2 H(+) = an 11beta-hydroxysteroid + 2 oxidized [adrenodoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:15629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35341"/>
            <dbReference type="ChEBI" id="CHEBI:35346"/>
            <dbReference type="EC" id="1.14.15.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:15630"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.4" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03013903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNV9"/>
    <dbReference type="Ensembl" id="ENSMICT00000002593.3">
        <property type="protein sequence ID" value="ENSMICP00000002366.3"/>
        <property type="gene ID" value="ENSMICG00000002589.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163354"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047783">
        <property type="term" value="F:corticosterone 18-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004507">
        <property type="term" value="F:steroid 11-beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032342">
        <property type="term" value="P:aldosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071375">
        <property type="term" value="P:cellular response to peptide hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034650">
        <property type="term" value="P:cortisol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006704">
        <property type="term" value="P:glucocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050479">
        <property type="entry name" value="CYP11_CYP27_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24279:SF1">
        <property type="entry name" value="CYTOCHROME P450 11B2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 18 19" id="KW-0349">Heme</keyword>
    <keyword evidence="9 18 19" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 19" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" description="axial binding residue" evidence="18">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002366.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="310" mass="35327" checksum="48CE3C11CFA00067" modified="2022-01-19" version="1">NKKEASNSALFGERLGLLGNNPSYASLKFIHALEAMFKSTVQLMYMPRSLSRWTSTKTWEEHFEAWDYIYQYGDKCIQKTYSELVGGCPSQHYRSVLAELLLHADLSPDAIKANAIELTAGSVDTTSFPLLMTFFELARNPDVQQALRQESLAAQASITDNPQRALVELPLLRAALKETLRLYPVGLFLERLLSSDMVLQNYHIPAGTLVQVFLHSLGRHSASFPRPERYEPQRWLEVKGSSTNFRHVAFGFGVRQCLGRRLAEVEMLLLLHHVLKTFLVETLNQEDVRMVYRFILRPTALPLLTFRAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UP97</accession>
    <name>A0A8C5UP97_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="9">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LSS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03033374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635521.1">
        <property type="nucleotide sequence ID" value="XM_012780067.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UP97"/>
    <dbReference type="Ensembl" id="ENSMICT00000004052.3">
        <property type="protein sequence ID" value="ENSMICP00000003691.2"/>
        <property type="gene ID" value="ENSMICG00000004051.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879670"/>
    <dbReference type="KEGG" id="mmur:105879670"/>
    <dbReference type="CTD" id="4047"/>
    <dbReference type="GeneTree" id="ENSGT00390000011570"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
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                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
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                <person name="Kurapati P."/>
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                <person name="Lee S."/>
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                <person name="Narasimhan A."/>
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                <person name="Nguyen L."/>
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                <person name="Quiroz J."/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032757">
        <property type="term" value="P:positive regulation of interleukin-8 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904996">
        <property type="term" value="P:positive regulation of leukocyte adhesion to vascular endothelial cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902895">
        <property type="term" value="P:positive regulation of miRNA transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050862">
        <property type="term" value="P:positive regulation of T cell receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099527">
        <property type="term" value="P:postsynapse to nucleus signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038161">
        <property type="term" value="P:prolactin signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032495">
        <property type="term" value="P:response to muramyl dipeptide"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to muscle stretch"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010224">
        <property type="term" value="P:response to UV-B"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023019">
        <property type="term" value="P:signal transduction involved in regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038124">
        <property type="term" value="P:toll-like receptor TLR6:TLR2 signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033209">
        <property type="term" value="P:tumor necrosis factor-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038084">
        <property type="term" value="P:vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01177">
        <property type="entry name" value="IPT_NFkappaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07885">
        <property type="entry name" value="RHD-n_RelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.340:FF:000003">
        <property type="entry name" value="NFkB p65 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000046">
        <property type="entry name" value="Nuclear factor NF-kappa-B p105 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.340">
        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033926">
        <property type="entry name" value="IPT_NFkappaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000451">
        <property type="entry name" value="NFkB/Dor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030495">
        <property type="entry name" value="RelA_RHD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030492">
        <property type="entry name" value="RHD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032397">
        <property type="entry name" value="RHD_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011539">
        <property type="entry name" value="RHD_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037059">
        <property type="entry name" value="RHD_DNA_bind_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169">
        <property type="entry name" value="NUCLEAR FACTOR NF-KAPPA-B PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24169:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR P65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16179">
        <property type="entry name" value="RHD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00554">
        <property type="entry name" value="RHD_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00057">
        <property type="entry name" value="NFKBTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01204">
        <property type="entry name" value="REL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50254">
        <property type="entry name" value="REL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RHD" evidence="10">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="310"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="551" mass="60424" checksum="32591484E06BBA6B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UYP8</accession>
    <name>A0A8C5UYP8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Anion exchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC4A5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 hydrogencarbonate(out) + Na(+)(out) = 2 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72215"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3 hydrogencarbonate(out) + Na(+)(out) = 3 hydrogencarbonate(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72219"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005158">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UYP8"/>
    <dbReference type="Ensembl" id="ENSMICT00000006138.3">
        <property type="protein sequence ID" value="ENSMICP00000005597.2"/>
        <property type="gene ID" value="ENSMICG00000006131.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157488"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008509">
        <property type="term" value="F:monoatomic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008510">
        <property type="term" value="F:sodium:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003014">
        <property type="term" value="P:renal system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000001">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.930.10:FF:000002">
        <property type="entry name" value="Anion exchange protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="entry name" value="Mannitol-specific EII, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013769">
        <property type="entry name" value="Band3_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003024">
        <property type="entry name" value="Na/HCO3_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00834">
        <property type="entry name" value="ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF20">
        <property type="entry name" value="ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07565">
        <property type="entry name" value="Band_3_cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01231">
        <property type="entry name" value="HCO3TRNSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01232">
        <property type="entry name" value="NAHCO3TRSPRT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="Phoshotransferase/anion transport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="490"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="850"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="920"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="Band 3 cytoplasmic" evidence="16">
        <location>
            <begin position="48"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="15">
        <location>
            <begin position="707"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="959"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005597.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113291" checksum="AAB66A909DF30DDE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V330</accession>
    <name>A0A8C5V330_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phospholipase B-like</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLBD1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Putative phospholipase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the phospholipase B-like family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03010227">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609184.1">
        <property type="nucleotide sequence ID" value="XM_012753730.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V330"/>
    <dbReference type="Ensembl" id="ENSMICT00000011741.3">
        <property type="protein sequence ID" value="ENSMICP00000010688.3"/>
        <property type="gene ID" value="ENSMICG00000011736.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865282"/>
    <dbReference type="KEGG" id="mmur:105865282"/>
    <dbReference type="CTD" id="79887"/>
    <dbReference type="GeneTree" id="ENSGT00530000063509"/>
    <dbReference type="OrthoDB" id="419508at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.60.20:FF:000001">
        <property type="entry name" value="Phospholipase B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.60">
        <property type="entry name" value="Phospholipase B-like, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.439.20">
        <property type="entry name" value="Phospholipase B-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007000">
        <property type="entry name" value="PLipase_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043040">
        <property type="entry name" value="PLipase_B-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043041">
        <property type="entry name" value="PLipase_B-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043042">
        <property type="entry name" value="PLipase_B-like_dom3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370:SF1">
        <property type="entry name" value="PHOSPHOLIPASE B-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12370">
        <property type="entry name" value="PHOSPHOLIPASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04916">
        <property type="entry name" value="Phospholip_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039447" description="Phospholipase B-like" evidence="10">
        <location>
            <begin position="31"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010688.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="551" mass="63221" checksum="ADB3E4906FBD538C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V446</accession>
    <name>A0A8C5V446_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ornithine decarboxylase</fullName>
            <ecNumber evidence="9">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ODC1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03012093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634432.1">
        <property type="nucleotide sequence ID" value="XM_012778978.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634433.1">
        <property type="nucleotide sequence ID" value="XM_012778979.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634434.1">
        <property type="nucleotide sequence ID" value="XM_012778980.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V446"/>
    <dbReference type="Ensembl" id="ENSMICT00000012510.3">
        <property type="protein sequence ID" value="ENSMICP00000011393.2"/>
        <property type="gene ID" value="ENSMICG00000012511.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879025"/>
    <dbReference type="KEGG" id="mmur:105879025"/>
    <dbReference type="CTD" id="4953"/>
    <dbReference type="GeneTree" id="ENSGT00950000182995"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000006">
        <property type="entry name" value="Ornithine decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF42">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="15">
        <location>
            <begin position="41"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="16">
        <location>
            <begin position="45"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011393.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="461" mass="51450" checksum="0F0316BE4B5BDB67" modified="2022-01-19" version="1">MNNFSNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHRRWLKALPRVTPFYAVKCNDSRAIVKTLATIGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAISDARYVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITSVVNPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQIGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPMWQLMQQIQNPDFTPEVEEQDVGTLPVSCAWESGMKRHRATCASASINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V4P7</accession>
    <name>A0A8C5V4P7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Ephrin type-A receptor 2</fullName>
            <ecNumber evidence="3">2.7.10.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="38" type="primary">EPHA2</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="26 40">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Cell projection</location>
            <location evidence="27">Lamellipodium membrane</location>
            <topology evidence="27">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03002301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V4P7"/>
    <dbReference type="Ensembl" id="ENSMICT00000016881.3">
        <property type="protein sequence ID" value="ENSMICP00000015383.3"/>
        <property type="gene ID" value="ENSMICG00000016876.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160786"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070160">
        <property type="term" value="C:tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048320">
        <property type="term" value="P:axial mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002043">
        <property type="term" value="P:blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046849">
        <property type="term" value="P:bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060444">
        <property type="term" value="P:branching involved in mammary gland duct morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046058">
        <property type="term" value="P:cAMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070309">
        <property type="term" value="P:lens fiber cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033598">
        <property type="term" value="P:mammary gland epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032682">
        <property type="term" value="P:negative regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901491">
        <property type="term" value="P:negative regulation of lymphangiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060035">
        <property type="term" value="P:notochord cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014028">
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6C5</accession>
    <name>A0A8C5V6C5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protocadherin beta 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PCDHB3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022494">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6C5"/>
    <dbReference type="Ensembl" id="ENSMICT00000016125.3">
        <property type="protein sequence ID" value="ENSMICP00000014697.3"/>
        <property type="gene ID" value="ENSMICG00000016131.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161193"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF302">
        <property type="entry name" value="PROTOCADHERIN BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="75"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="12">
        <location>
            <begin position="437"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="389"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="702"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014697.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="733" mass="79636" checksum="AD62831D413EF6C4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7C0</accession>
    <name>A0A8C5V7C0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Myosin-binding protein H-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MYBPHL</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Myosin-binding protein which plays a role in cardiac function. Seems to regulate conduction in the atria and ventricular conduction systems.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the immunoglobulin superfamily. MyBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7C0"/>
    <dbReference type="Ensembl" id="ENSMICT00000016335.3">
        <property type="protein sequence ID" value="ENSMICP00000014888.3"/>
        <property type="gene ID" value="ENSMICG00000016334.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162165"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036379">
        <property type="term" value="C:myofilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000977">
        <property type="entry name" value="Myosin binding protein H like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000031">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000062">
        <property type="entry name" value="Myosin-binding protein C, slow type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050964">
        <property type="entry name" value="Striated_Muscle_Regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817:SF49">
        <property type="entry name" value="MYOSIN-BINDING PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13817">
        <property type="entry name" value="TITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="45"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="13">
        <location>
            <begin position="148"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="261"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014888.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="357" mass="39197" checksum="92934A6389699F0B" modified="2022-01-19" version="1">MEAATAPEVASGSKLKVKEAIPADAERPQTPPGQGAGCPTPQLLPPIEEHPKIWLPRALRQTYIRKVGDTVNLLIPFQGKPKPQATWTHNGCALDTSRVSVRNGEQDSILFIREAQRADSGRYQLRVQLGGLEATATVDILVIERPGPPQSIKLVDVWGFNATLEWTPPQDTGNTALLGYTVQKADTKSGLWFTVLERYHRTSCIVSDLIVGNSYAFRVFAENQCGLSETAPITADLAHIQKAATIYKTKGFAQRDFSEAPKFTQPLADCTTVTGYDTQLFCCVRASPRPKIIWLKNKMDIQGNPKYRALTHLGICSLEIRKPGPFDGGIYTCKAVNPLGEASVDCRVDVKENIPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V981</accession>
    <name>A0A8C5V981_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SAM and SH3 domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SASH1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with GNAS. Interacts with IQGAP1. Interacts with TRAF6 (via C-terminus); the interaction is LPS-dependent. Interacts with MAP3K7, CHUK and IKBKB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03008542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V981"/>
    <dbReference type="Ensembl" id="ENSMICT00000014494.3">
        <property type="protein sequence ID" value="ENSMICP00000013211.3"/>
        <property type="gene ID" value="ENSMICG00000014483.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156778"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031435">
        <property type="term" value="F:mitogen-activated protein kinase kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010595">
        <property type="term" value="P:positive regulation of endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031666">
        <property type="term" value="P:positive regulation of lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010632">
        <property type="term" value="P:regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902498">
        <property type="term" value="P:regulation of protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900044">
        <property type="term" value="P:regulation of protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09559">
        <property type="entry name" value="SAM_SASH1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09492">
        <property type="entry name" value="SAM_SASH1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11967">
        <property type="entry name" value="SH3_SASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000024">
        <property type="entry name" value="Putative sam and sh3 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000038">
        <property type="entry name" value="Putative sam and sh3 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000021">
        <property type="entry name" value="Putative sam and sh3 domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051725">
        <property type="entry name" value="SAM-SH3_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058666">
        <property type="entry name" value="SASH1/NUB1_homeodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037627">
        <property type="entry name" value="SASH1_SAM_repeat1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037630">
        <property type="entry name" value="SASH1_SAM_repeat2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035720">
        <property type="entry name" value="SASH1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021090">
        <property type="entry name" value="SPIDER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301:SF3">
        <property type="entry name" value="SAM AND SH3 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12301">
        <property type="entry name" value="SAM-DOMAIN, SH3 AND NUCLEAR LOCALIZATION SIGNALS PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26285">
        <property type="entry name" value="SASH1_Homeodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12485">
        <property type="entry name" value="SPIDER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="549"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="628"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="1175"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="829"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="723"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="889"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="944"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1005"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013211.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1241" mass="135871" checksum="A38D52A68E8F400F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VF91</accession>
    <name>A0A8C5VF91_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase PLK</fullName>
            <ecNumber evidence="17">2.7.11.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Polo-like kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PLK2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with NSF; causing NSF dissociation from GRIA2. Interacts with CIB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.21" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03016536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631097.1">
        <property type="nucleotide sequence ID" value="XM_012775643.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VF91"/>
    <dbReference type="Ensembl" id="ENSMICT00000041042.2">
        <property type="protein sequence ID" value="ENSMICP00000021870.1"/>
        <property type="gene ID" value="ENSMICG00000014702.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877267"/>
    <dbReference type="KEGG" id="mmur:105877267"/>
    <dbReference type="CTD" id="10769"/>
    <dbReference type="GeneTree" id="ENSGT00940000158739"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043008">
        <property type="term" value="F:ATP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071866">
        <property type="term" value="P:negative regulation of apoptotic process in bone marrow cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046599">
        <property type="term" value="P:regulation of centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13117">
        <property type="entry name" value="POLO_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14188">
        <property type="entry name" value="STKc_PLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001498">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000091">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042825">
        <property type="entry name" value="PLK2_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033695">
        <property type="entry name" value="POLO_box_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF44">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="82"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="20">
        <location>
            <begin position="503"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="20">
        <location>
            <begin position="601"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="685" mass="78283" checksum="DE91116319660A84" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VH79</accession>
    <name>A0A8C5VH79_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">GTP-binding nuclear protein Ran</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VH79"/>
    <dbReference type="Ensembl" id="ENSMICT00000036396.2">
        <property type="protein sequence ID" value="ENSMICP00000022309.2"/>
        <property type="gene ID" value="ENSMICG00000032228.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153786"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022309.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="134" mass="15245" checksum="A0A1BB4092539871" modified="2022-01-19" version="1">MSDGTPRVTYKNVPNWRRDLARICENIPVVLCDNKVDIKDRKVKAKSIVFHRKKNLQGYDISAKSNYDFERPFLWLARKLAGDPALESVAMPTLAPPEAVTARCERDLEVAQTTALPNEDDDSREWSWSPASEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHB0</accession>
    <name>A0A8C5VHB0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcitonin receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CALCR</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer of CALCR and RAMP1, RAMP2 or RAMP3; the receptor complexes function as AMYR1, AMYR2 and AMYR3 receptors, respectively, and respond to amylin/IAPP, calcitonin/CT and CGRP1 ligands. Interacts with GPRASP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015481">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635105.1">
        <property type="nucleotide sequence ID" value="XM_012779651.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VHB0"/>
    <dbReference type="Ensembl" id="ENSMICT00000049626.2">
        <property type="protein sequence ID" value="ENSMICP00000020589.2"/>
        <property type="gene ID" value="ENSMICG00000002792.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879418"/>
    <dbReference type="CTD" id="799"/>
    <dbReference type="GeneTree" id="ENSGT00940000155380"/>
    <dbReference type="OrthoDB" id="16753at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150056">
        <property type="term" value="C:amylin receptor complex 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150057">
        <property type="term" value="C:amylin receptor complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150058">
        <property type="term" value="C:amylin receptor complex 3"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097643">
        <property type="term" value="F:amylin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032841">
        <property type="term" value="F:calcitonin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001635">
        <property type="term" value="F:calcitonin gene-related peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004948">
        <property type="term" value="F:calcitonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of ossification"/>
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        <property type="term" value="P:osteoclast differentiation"/>
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        <property type="term" value="P:positive regulation of calcium-mediated signaling"/>
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        <property type="term" value="P:positive regulation of cAMP/PKA signal transduction"/>
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        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
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        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
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        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to amyloid-beta"/>
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        <property type="term" value="P:response to glucocorticoid"/>
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        <property type="entry name" value="7tmB1_calcitonin_R"/>
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        <property type="entry name" value="Calcitonin receptor"/>
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        <property type="entry name" value="Calcitonin receptor"/>
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        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_2"/>
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        <property type="entry name" value="GPCR_2_calcitonin_rcpt"/>
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        <property type="entry name" value="CALCITONIN RECEPTOR"/>
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        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="CALCITONINR"/>
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        <property type="entry name" value="CTRFAMILY"/>
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        <property type="entry name" value="GPCRSECRETIN"/>
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        <property type="entry name" value="Hormone receptor domain"/>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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            <begin position="23"/>
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    <feature type="transmembrane region" description="Helical" evidence="16">
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    <sequence length="477" mass="55308" checksum="70D705B7B9AE56DF" modified="2022-01-19" version="1">MKIKSMCQWLALFILLSHPTLTLRSSSSGNTSTTEPEPFLYTIGRKKLQEAEKKCYERMQQMPPYQGEGPYCNRTWDGWMCWDDTPAGETSVQSCPGYFPDFDPSERVTRYCDETGVWFKHPETNESWSNYTLCNSFTPEKIQNAYILYYLALVGHSLSIITLIAALGVFFYFKRLGCQRVTLHKHLFVTYVMNSIIIIVHLLVVVPNGNLVRRDPASCKILHFFHQYMMSCNYFWMLCEGIYLHTLIVMAVFVERQRMWWYYLLGWGFPALPTVAHAITRAVYYDDNCWLSMETYLLYIIHGPVMAALVINFFFLLNIVRVLVVKMKQTREPESYMYLKAVKATLILVPLLGIQFVIFPWRPSNKVLGQIYDYVMHSLIHFQGFFVAVIHCFCNSEVQTTLKRHWAQYKLQRNRWGSRPSNRSAARAAAAAAAEAGDIPIYICHQELRNELAIDVEEEEEGVEIIPLNVIEQESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLQ9</accession>
    <name>A0A8C5VLQ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pregnancy zone protein-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105861536</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039550.2">
        <property type="protein sequence ID" value="ENSMICP00000022204.2"/>
        <property type="gene ID" value="ENSMICG00000027775.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163775"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02897">
        <property type="entry name" value="A2M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000312">
        <property type="entry name" value="Alpha-2-macroglobulin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000001">
        <property type="entry name" value="CD109 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000001">
        <property type="entry name" value="CD109 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1930:FF:000002">
        <property type="entry name" value="PZP, alpha-2-macroglobulin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.690:FF:000001">
        <property type="entry name" value="PZP, alpha-2-macroglobulin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.130.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1930">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.690">
        <property type="entry name" value="Alpha-macroglobulin, receptor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009048">
        <property type="entry name" value="A-macroglobulin_rcpt-bd"/>
    </dbReference>
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        <property type="entry name" value="A2M/Complement_sys"/>
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        <property type="entry name" value="A2M_N_BRD"/>
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        <property type="entry name" value="A2M_TED"/>
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    <dbReference type="InterPro" id="IPR047565">
        <property type="entry name" value="Alpha-macroglob_thiol-ester_cl"/>
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    <dbReference type="InterPro" id="IPR011626">
        <property type="entry name" value="Alpha-macroglobulin_TED"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_E-set"/>
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    <dbReference type="InterPro" id="IPR001599">
        <property type="entry name" value="Macroglobln_a2"/>
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    <dbReference type="InterPro" id="IPR019742">
        <property type="entry name" value="MacrogloblnA2_CS"/>
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    <dbReference type="InterPro" id="IPR002890">
        <property type="entry name" value="MG2"/>
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        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
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        <property type="entry name" value="MACROGLOBULIN / COMPLEMENT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PREGNANCY ZONE PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A2M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="A2M_recep"/>
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        <property type="entry name" value="MG2"/>
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        <property type="entry name" value="A2M"/>
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        <property type="entry name" value="A2M_N_2"/>
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        <property type="entry name" value="A2M_recep"/>
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    <dbReference type="SMART" id="SM01419">
        <property type="entry name" value="Thiol-ester_cl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49410">
        <property type="entry name" value="Alpha-macroglobulin receptor domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00477">
        <property type="entry name" value="ALPHA_2_MACROGLOBULIN"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0082">Bait region</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034070797" description="Pregnancy zone protein-like" evidence="11">
        <location>
            <begin position="25"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin bait region" evidence="12">
        <location>
            <begin position="464"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-2-macroglobulin" evidence="13">
        <location>
            <begin position="754"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-macroglobulin receptor-binding" evidence="14">
        <location>
            <begin position="1392"/>
            <end position="1479"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010952"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023248"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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        <source>
            <dbReference type="SMART" id="SM01360"/>
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        <source>
            <dbReference type="SMART" id="SM01361"/>
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    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022204.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1492" mass="166641" checksum="4A9A9D04570586CC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VML4</accession>
    <name>A0A8C5VML4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plastin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">T-plastin</fullName>
        </alternativeName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Actin-bundling protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03034731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000045987.2">
        <property type="protein sequence ID" value="ENSMICP00000026172.2"/>
        <property type="gene ID" value="ENSMICG00000026701.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183097"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21334">
        <property type="entry name" value="CH_PLS3_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000042">
        <property type="entry name" value="Fimbrin, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000010">
        <property type="entry name" value="Plastin-3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF32">
        <property type="entry name" value="PLASTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="24"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="87"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="217"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="396"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026172.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="508" mass="57113" checksum="049686F52FA30E94" modified="2022-01-19" version="1">MDEMATTYISKDELDELKEAFPKVEPESDRKLMLDGDRNKDGKISFDEFVYIFQEVKSSDIAKTFRKAINRKEGICALGRTSELSSKGTQHSYSLWKMIPIAPVIPMNPNTDNLFKAVGDGIVLCKMINLSVPDTIEKRIINKKKLTPSIIQENLNLALNSASATGCHVVNIGSEDLWAGKPHLVWGLLWQIIKIGLFTDIELSRNEALAALLRDGETLEELMKLSPEEHLLRWVYFHLENSGCADIKDSKAYFHLLNQIAPKGQKEGESQIDINMSGFNETDDLKRAESMLQQPDKLGCRQFVTLADVVGGNPKLNLAFVANLFNKYLALNKPENKDIDWTLLEETCEERTFCNWMNSLSVNPPVNHLYADLQDALQLMRRYTLIVLEDLGEGQKANDGIIVNWVNRTLSEAGKSTSIQSFKDKMISFSLAVVDLINAIQPGCINYDLVKSSNLTEDDKHNNAKYAVSMARIIGARVYALPEDLVEVKPKMVMTVFACLMGRGMKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNC4</accession>
    <name>A0A8C5VNC4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box E3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FOXE3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNC4"/>
    <dbReference type="Ensembl" id="ENSMICT00000045116.2">
        <property type="protein sequence ID" value="ENSMICP00000026716.2"/>
        <property type="gene ID" value="ENSMICG00000029422.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163987"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061073">
        <property type="term" value="P:ciliary body morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061303">
        <property type="term" value="P:cornea development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050673">
        <property type="term" value="P:epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061072">
        <property type="term" value="P:iris morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902747">
        <property type="term" value="P:negative regulation of lens fiber cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001111">
        <property type="term" value="P:positive regulation of lens epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002930">
        <property type="term" value="P:trabecular meshwork development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20019">
        <property type="entry name" value="FH_FOXE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000201">
        <property type="entry name" value="Forkhead box E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF156">
        <property type="entry name" value="FORKHEAD BOX PROTEIN E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="71"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="71"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026716.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="305" mass="32146" checksum="ACD64589277B99A9" modified="2022-01-19" version="1">MAGRGDMDPPATFSGFPALPSVAPSGPPPSPLAGGEPGREPEEAAAGRGEADCTPAPGPGRRRRRPLQRGKPPYSYIALIAMALAHAPGRRLTLAAIYRFITERFAFYRDSPRKWQNSIRHNLTLNDCFVKVPREPGNPGKGNYWTLDPAAADMFDNGSFLRRRNCPHTRPRRRGPRSPSPTRPTRPRPARAARAAAPAAGGAARALFSVDSLVSLQPELAAAPPSRRAAPAGRAFAPCGAAASPPLYAQAPERLGLPATRPGPGPLPAEPLLALGGPAAALGPLSPGEAYLRQPGFAPGLERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VPL8</accession>
    <name>A0A8C5VPL8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Adhesion G protein-coupled receptor L3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Latrophilin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">ADGRL3</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. Isoform 1 is specifically coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Following G-protein coupled receptor activation, undergoes liquid-liquid phase transition, associates with (1) cell adhesion molecules that are expressed at the surface of adjacent cells, as well as (2) PDZ-containing proteins, such as SHANK3 and DLG4, in the cytoplasm to direct synapse formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="26">Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts (via olfactomedin-like domain) with FLRT1 (via extracellular domain). Interacts (via olfactomedin-like domain) with FLRT2 (via extracellular domain). Interacts (via olfactomedin-like domain) with FLRT3 (via extracellular domain); the interaction is direct. Interacts (via extracellular domain) with TENM1. Interacts (via extracellular domain) with TENM2. Interacts (via extracellular domain) with TENM3. Identified in a complex with FLRT3 and UNC5B; does not interact with UNC5B by itself. Identified in a complex with FLRT3 and UNC5D; does not interact with UNC5D by itself.</text>
    </comment>
    <comment type="subunit">
        <text evidence="25">Interacts (via PDZ-binding motif) with SHANK3. Interacts (via PDZ-binding motif) with DLG4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Postsynaptic cell membrane</location>
            <topology evidence="21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029171">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029173">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029174">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="primary">MAB21L3</name>
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            <taxon>Eukaryota</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mab-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRI4"/>
    <dbReference type="Ensembl" id="ENSMICT00000050368.2">
        <property type="protein sequence ID" value="ENSMICP00000028659.1"/>
        <property type="gene ID" value="ENSMICG00000032799.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244827"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046903">
        <property type="entry name" value="Mab-21-like_nuc_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046906">
        <property type="entry name" value="Mab-21_HhH/H2TH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024810">
        <property type="entry name" value="MAB21L/cGLR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656">
        <property type="entry name" value="CELL FATE DETERMINING PROTEIN MAB21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10656:SF30">
        <property type="entry name" value="PROTEIN MAB-21-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03281">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20266">
        <property type="entry name" value="Mab-21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01265">
        <property type="entry name" value="Mab-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mab-21-like nucleotidyltransferase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Mab-21-like HhH/H2TH-like" evidence="3">
        <location>
            <begin position="255"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="362" mass="41916" checksum="6F4A3894931A672C" modified="2022-01-19" version="1">MKSLPAGNLEDCLLSKVDSRRQRISQTVEEVQKVIHQLTTEISHQDIRFQAVPHFDTYNRNIKVLAPGQFLVTVPIKGLAGYREASEQRWRYYTLQGARLPCPLPAPEGLQQWLEVEQFVKSLWQWHEADVNIEGDIVPAKVLQVFRKLVENAIRTCHLSGKVSMLANRAAVWVAVETSGGQVELELAPAVEIPTTWSQKARWPRCLQRWPSPERVKCIKSFGFNLLARSNYHWELSFLQAEQVLLEQLDEDGGCRRKCLQVMRQLKEDVWCPGKRPVLTSHHLQTVLFWTCEKYPHFKDWQVFSKAFLRLVRKLHKCVSQHFLKHYFVRNSNLLRCANSGELDAVAQKLAFFLKNPQISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VST7</accession>
    <name>A0A8C5VST7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Piwi-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PIWIL1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the argonaute family. Piwi subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03025101">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622474.1">
        <property type="nucleotide sequence ID" value="XM_012767020.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138505.1">
        <property type="nucleotide sequence ID" value="XM_020282916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VST7"/>
    <dbReference type="Ensembl" id="ENSMICT00000028923.2">
        <property type="protein sequence ID" value="ENSMICP00000029491.1"/>
        <property type="gene ID" value="ENSMICG00000004852.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872756"/>
    <dbReference type="KEGG" id="mmur:105872756"/>
    <dbReference type="CTD" id="9271"/>
    <dbReference type="GeneTree" id="ENSGT00950000183200"/>
    <dbReference type="OrthoDB" id="445936at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033391">
        <property type="term" value="C:chromatoid body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097433">
        <property type="term" value="C:dense body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140262">
        <property type="term" value="F:mRNA cap binding complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034584">
        <property type="term" value="F:piRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140991">
        <property type="term" value="P:piRNA-mediated gene silencing by mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140990">
        <property type="term" value="P:primary piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035092">
        <property type="term" value="P:sperm DNA condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141006">
        <property type="term" value="P:transposable element silencing by piRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02845">
        <property type="entry name" value="PAZ_piwi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04658">
        <property type="entry name" value="Piwi_piwi-like_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000014">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000131">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000003">
        <property type="entry name" value="Piwi-like RNA-mediated gene silencing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031320">
        <property type="entry name" value="GAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05831">
        <property type="entry name" value="GAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23278">
        <property type="entry name" value="Piwi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01379">
        <property type="entry name" value="GAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="13" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="12" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="20">
        <location>
            <begin position="279"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="21">
        <location>
            <begin position="556"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="862" mass="98619" checksum="1F78FE270699D8DE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VV86</accession>
    <name>A0A8C5VV86_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Synemin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SYNM</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VV86"/>
    <dbReference type="Ensembl" id="ENSMICT00000033395.2">
        <property type="protein sequence ID" value="ENSMICP00000028508.1"/>
        <property type="gene ID" value="ENSMICG00000007299.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159268"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043034">
        <property type="term" value="C:costamere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060053">
        <property type="term" value="C:neurofilament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019215">
        <property type="term" value="F:intermediate filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017166">
        <property type="term" value="F:vinculin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031443">
        <property type="term" value="P:fast-twitch skeletal muscle fiber contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030634">
        <property type="entry name" value="SYNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47136">
        <property type="entry name" value="SYNEMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47136:SF1">
        <property type="entry name" value="SYNEMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="29"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="291"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="998"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1136" mass="125612" checksum="0C150D1B29967F41" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYX4</accession>
    <name>A0A8C5VYX4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">GDP-fucose protein O-fucosyltransferase 2</fullName>
            <ecNumber evidence="4">2.4.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Peptide-O-fucosyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">POFUT2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.221" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03033340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03033341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033342">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033345">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033349">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635490.1">
        <property type="nucleotide sequence ID" value="XM_012780036.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYX4"/>
    <dbReference type="Ensembl" id="ENSMICT00000051981.2">
        <property type="protein sequence ID" value="ENSMICP00000029039.1"/>
        <property type="gene ID" value="ENSMICG00000035479.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879662"/>
    <dbReference type="KEGG" id="mmur:105879662"/>
    <dbReference type="CTD" id="23275"/>
    <dbReference type="GeneTree" id="ENSGT00390000007989"/>
    <dbReference type="OrthoDB" id="422368at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903334">
        <property type="term" value="P:positive regulation of protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010717">
        <property type="term" value="P:regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051046">
        <property type="term" value="P:regulation of secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11298">
        <property type="entry name" value="O-FucT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11340:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000002">
        <property type="entry name" value="GDP-fucose protein O-fucosyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150183" description="GDP-fucose protein O-fucosyltransferase 2" evidence="20">
        <location>
            <begin position="22"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="429" mass="49884" checksum="602F278C89BDCB00" modified="2022-01-19" version="1">MAPLFVVFLLLWAASWPPASASGEEFWPGQSAAGILSGAASRRRYLLYDVNPPEGFNLRRDVYIRVASLLKTLLKSEEWVLVLPPWGHLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQGYAEGWKEGSWEEKVDERPCIDRLLYLQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIIAPVLLKNTSARSVMLDRAENLFHDHYGGREYWDTRRSMVFARHLRAVGDEFRSRYLNSTDQADKIPFKEDWTKMKVKMGSSLGGPYLGVHLRRKDFIWGHREDVPSLKGAVRTIRSLMRAHQLDKVFVATDAVRKEHKELKRLLPEMVRFEPTWEELELYKDGGVAIIDQWVCSHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0W0</accession>
    <name>A0A8C5W0W0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CASP8-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">FLICE-associated huge protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CASP8AP2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007662">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606413.1">
        <property type="nucleotide sequence ID" value="XM_012750959.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606414.1">
        <property type="nucleotide sequence ID" value="XM_012750960.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000046997.2">
        <property type="protein sequence ID" value="ENSMICP00000030145.2"/>
        <property type="gene ID" value="ENSMICG00000032939.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000062276.1">
        <property type="protein sequence ID" value="ENSMICP00000044948.1"/>
        <property type="gene ID" value="ENSMICG00000032939.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863626"/>
    <dbReference type="KEGG" id="mmur:105863626"/>
    <dbReference type="CTD" id="9994"/>
    <dbReference type="GeneTree" id="ENSGT00620000088063"/>
    <dbReference type="OrthoDB" id="1938039at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036337">
        <property type="term" value="P:Fas signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12202">
        <property type="entry name" value="CASP8AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000265">
        <property type="entry name" value="CASP8-associated protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039674">
        <property type="entry name" value="FLASH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049257">
        <property type="entry name" value="Gon4l/CASP8AP2_myb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15489:SF2">
        <property type="entry name" value="CASP8-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15489">
        <property type="entry name" value="CASPASE 8 ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21227">
        <property type="entry name" value="Myb_DNA-binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="161"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="230"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="866"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="924"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="18">
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        <location>
            <begin position="1783"/>
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        <location>
            <begin position="73"/>
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    </feature>
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        <location>
            <begin position="161"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
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        <location>
            <begin position="462"/>
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        <location>
            <begin position="499"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
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        <location>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="1962" mass="221163" checksum="A96B50A83235871A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1N5</accession>
    <name>A0A8C5W1N5_MICMU</name>
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        <recommendedName>
            <fullName evidence="13">tRNA (guanine(10)-N(2))-methyltransferase TRMT11</fullName>
            <ecNumber evidence="12">2.1.1.214</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">tRNA methyltransferase 11 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TRMT11</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(10) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(10) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43128"/>
            <dbReference type="Rhea" id="RHEA-COMP:10355"/>
            <dbReference type="Rhea" id="RHEA-COMP:10357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
            <dbReference type="EC" id="2.1.1.214"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:43129"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the heterodimeric TRMT11-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit TRMT11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03008394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632944.1">
        <property type="nucleotide sequence ID" value="XM_012777490.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1N5"/>
    <dbReference type="Ensembl" id="ENSMICT00000046517.2">
        <property type="protein sequence ID" value="ENSMICP00000034861.1"/>
        <property type="gene ID" value="ENSMICG00000029227.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878193"/>
    <dbReference type="KEGG" id="mmur:105878193"/>
    <dbReference type="CTD" id="60487"/>
    <dbReference type="GeneTree" id="ENSGT00390000018131"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043528">
        <property type="term" value="C:tRNA (m2G10) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA (Guanine(10)-N2)-methyltransferase homolog isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="16">
        <location>
            <begin position="190"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="460" mass="52986" checksum="567E85F929A3226D" modified="2022-01-19" version="1">MALPCNLNRYLLLMAQEHLEFRLPEIKSLLSLFGGQFANSQETYGKSPFWILSIPSEEIARNLMKRTVCAKSIFELWGHGKSPEELYSSLKSYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKVKRIDALEFLPFEGKVNLKKPQHIFSVLEDYGLDPNHIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKANDIVFDPFVGTGGLLIASAHFGAYVYGTDIDYNTVHGLGKASRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKCPESHVPVSLSYHLSDMYFDLLNFAAETLVLGGRLVYWLPVYTPEYSEEMVPWHPCLELISNCEQKLSSHTSRRLITMEKVKKFENRDQYSHLLSDHFLPYQGHNSFREKYFSGVTKRISKEEKSSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2Y3</accession>
    <name>A0A8C5W2Y3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Coagulation factor II thrombin receptor like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">F2RL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016566">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593805.1">
        <property type="nucleotide sequence ID" value="XM_012738351.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2Y3"/>
    <dbReference type="Ensembl" id="ENSMICT00000047133.2">
        <property type="protein sequence ID" value="ENSMICP00000030552.2"/>
        <property type="gene ID" value="ENSMICG00000036441.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856534"/>
    <dbReference type="KEGG" id="mmur:105856534"/>
    <dbReference type="CTD" id="2151"/>
    <dbReference type="GeneTree" id="ENSGT01050000244840"/>
    <dbReference type="OrthoDB" id="8859266at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015057">
        <property type="term" value="F:thrombin-activated receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990806">
        <property type="term" value="P:ligand-gated ion channel signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15371">
        <property type="entry name" value="7tmA_PAR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000040">
        <property type="entry name" value="Coagulation factor 2 (thrombin) receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003943">
        <property type="entry name" value="Prot_act_rcpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003912">
        <property type="entry name" value="Protea_act_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24232:SF0">
        <property type="entry name" value="PROTEINASE-ACTIVATED RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01428">
        <property type="entry name" value="PROTEASEAR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01429">
        <property type="entry name" value="PROTEASEAR3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="10 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150201" evidence="14">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="111"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="166"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030552.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="378" mass="42776" checksum="DB54A90D1A32B477" modified="2022-01-19" version="1">MKDLISAAAGLLLLVPSFCQSGMKDDADNWATPTLPIKTFRGAPPNSFEVFPHSAIEGRTEDILTVKIKCPEESVSNLLVNNATMGYLSSSLSTKLIPAIYILVFVVGVPANAVTLWMLFFRTRSVCTAVFYTNLAIADLLLCVTLPFKIAYHLNGNNWVFGEVMCRATTVIFYGNMYCSILLLTCISINRYLAIVHPFTYRGLPKRTYALLTCGLVWATVFLYMLPFLILKQEYYLVQPDITTCHDVHNTCESSSLFQLFYFISLAFFGFLIPFVVIIYCYTAIIRTLNAYDHRWLWYVKASLLILAIFTICFAPSNIILIIHHANYYYDSTDGLYFIYLIALCLGSLNSCLDPFLYFLMSKIRDHSTAYLTTVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W510</accession>
    <name>A0A8C5W510_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein 198</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC105864877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM198 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608511.1">
        <property type="nucleotide sequence ID" value="XM_012753057.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W510"/>
    <dbReference type="Ensembl" id="ENSMICT00000051324.2">
        <property type="protein sequence ID" value="ENSMICP00000037295.1"/>
        <property type="gene ID" value="ENSMICG00000038463.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105864877"/>
    <dbReference type="GeneTree" id="ENSGT00390000016940"/>
    <dbReference type="OrthoDB" id="115781at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040236">
        <property type="entry name" value="TMEM198"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31247:SF8">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 198B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="9">
        <location>
            <begin position="45"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="350" mass="37512" checksum="CE0A4DB5ED5DA910" modified="2022-01-19" version="1">MEEALLPLAVMSESRPFNQQLPEPPEPSCVLEPQDNPELAPALVCALCCCFGIIYCCFGYRCFKAVMFLSGLLSGALVIFLLCHKERVLETQLSLEVSAGIALGIGLLCGLVTMLVRSVGLFLTGLLLGLTLGAGALLGTEPIYQPPSAWVPGGGLVGLALLGALLTLRWPRLFTTLGTAMLGAAVLVACADYFLEGLALGSRLGQRLQALPALPPLCWYSWVLLGTWPALGALGALAQWKLMAEEHGVHNNVVLSHQRRHLQLLRIHQQEAKWHRTPSGVGLCESSYRRQSPHNARSPADSLAPSYLQSLRERQLGPGPQATSPHTILDLDSDCGSTVPLTTHSGSTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W675</accession>
    <name>A0A8C5W675_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CES4A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03024306">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024307">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W675"/>
    <dbReference type="Ensembl" id="ENSMICT00000041450.2">
        <property type="protein sequence ID" value="ENSMICP00000035877.2"/>
        <property type="gene ID" value="ENSMICG00000030422.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162924"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="13"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035877.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="465" mass="52394" checksum="FC29EF52DC43751A" modified="2022-01-19" version="1">IYFNTRKPYQWLRFSEDCLYLNVYAPARARGDRMMPVMVWFPGGAFLVGSASTYDGSELAAREKVVLVSLQHRLGILGFLSTGDSQARGNWALLDQVAALRWVQENIMAFGGDPGSVTLFGQSSGAMCISGLMMSPLAQGLFHRAISQSGTAVLKIFITPDPLKVAKKVARLAGCNHNSTQILVKCLRALSGAKVIHVSKKMKFYHQHLNSQEDPREIIWFVSPVVDGVVFPDDPVVLLTQGQVSPVPYLLGVNNMEFNWLLPYVMNFPLNQCAMKTEVITRILWSTSTLLNITKEQVPLVMEEYLGDIDECDWKMLRNRVIDLCGDATFVYSTLQTGRYHRDAGLPVYLYEFKHRAPKGIIVKPRTDGADHGDEIHFIFGSPFSKGPSTGEEKALSLQMMKYWANFARTGNPNGEKLPCWPRYDKDEKYLQLDVNTSVGVKLKEQKMAFWTRLHQPQSPEQKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W6H4</accession>
    <name>A0A8C5W6H4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ASXL transcriptional regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ASXL2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asx family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011916">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000049148.2">
        <property type="protein sequence ID" value="ENSMICP00000033238.2"/>
        <property type="gene ID" value="ENSMICG00000038141.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055578"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035517">
        <property type="term" value="C:PR-DUB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042975">
        <property type="term" value="F:peroxisome proliferator activated receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035360">
        <property type="term" value="P:positive regulation of peroxisome proliferator activated receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026905">
        <property type="entry name" value="ASX-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024811">
        <property type="entry name" value="ASX/ASX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007759">
        <property type="entry name" value="Asxl_HARE-HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578">
        <property type="entry name" value="ADDITIONAL SEX COMBS LIKE PROTEIN ASXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13578:SF11">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN ASXL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05066">
        <property type="entry name" value="HARE-HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13922">
        <property type="entry name" value="PHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W6Z5</accession>
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            <fullName evidence="14">Assembly factor for spindle microtubules</fullName>
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        <name type="scientific">Microcebus murinus</name>
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        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W7L0</accession>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Bandaranaike D."/>
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                <person name="Gnanaolivu R."/>
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                <person name="Jayaseelan J."/>
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                <person name="Quiroz J."/>
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                <person name="Rajbhandari K."/>
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                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
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                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Bandaranaike D."/>
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                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
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                <person name="Kurapati P."/>
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                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Sullivan B."/>
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                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
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                <person name="Muzny D.M."/>
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                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amelogenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035904">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W9V3"/>
    <dbReference type="Ensembl" id="ENSMICT00000027361.2">
        <property type="protein sequence ID" value="ENSMICP00000036482.2"/>
        <property type="gene ID" value="ENSMICG00000034215.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009151"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030345">
        <property type="term" value="F:structural constituent of tooth enamel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070166">
        <property type="term" value="P:enamel mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004116">
        <property type="entry name" value="Amelogenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46794:SF2">
        <property type="entry name" value="AMELOGENIN, X ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46794">
        <property type="entry name" value="AMELOGENIN, Y ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02948">
        <property type="entry name" value="Amelogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01757">
        <property type="entry name" value="AMELOGENIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00818">
        <property type="entry name" value="Amelogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034600316" evidence="7">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036482.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="192" mass="21748" checksum="D7540F351963AACE" modified="2022-01-19" version="1">MGTWILFACLLGAAFAMPLPPHPGHPGYINFSYEVLTPLKWYQSMIRPPYPSYGYEPMGGWLHHQIIPVLSQQHPQTHTLQPHHHIPVVPAQQPVVPQQPMMPVPGQHSMTPTHHHQPNLPPPAQQPFQPQPVQPQPHQPMQPQPPLHPMQPLPPQPHLPPLFPMQPLPPMLPDLPLEAWPATDKTKREEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAE5</accession>
    <name>A0A8C5WAE5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Fibroblast activation protein alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FAP</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Invadopodium membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Lamellipodium membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011244">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011245">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615844.1">
        <property type="nucleotide sequence ID" value="XM_012760390.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WAE5"/>
    <dbReference type="Ensembl" id="ENSMICT00000043777.2">
        <property type="protein sequence ID" value="ENSMICP00000037536.1"/>
        <property type="gene ID" value="ENSMICG00000005381.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868962"/>
    <dbReference type="KEGG" id="mmur:105868962"/>
    <dbReference type="CTD" id="2191"/>
    <dbReference type="GeneTree" id="ENSGT00940000160454"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905368">
        <property type="term" value="C:peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043542">
        <property type="term" value="P:endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902362">
        <property type="term" value="P:melanocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097325">
        <property type="term" value="P:melanocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060244">
        <property type="term" value="P:negative regulation of cell proliferation involved in contact inhibition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010716">
        <property type="term" value="P:negative regulation of extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010710">
        <property type="term" value="P:regulation of collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.140.10.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002471">
        <property type="entry name" value="Pept_S9_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF136">
        <property type="entry name" value="PROLYL ENDOPEPTIDASE FAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00708">
        <property type="entry name" value="PRO_ENDOPEP_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="12">
        <location>
            <begin position="106"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="11">
        <location>
            <begin position="554"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="760" mass="87326" checksum="2F137F9800BD393B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XCA3</accession>
    <name>A0A8C5XCA3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ferroxidase</fullName>
            <ecNumber evidence="4">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">HEPHL1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03006657">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595121.1">
        <property type="nucleotide sequence ID" value="XM_012739667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XCA3"/>
    <dbReference type="Ensembl" id="ENSMICT00000006403.3">
        <property type="protein sequence ID" value="ENSMICP00000005844.2"/>
        <property type="gene ID" value="ENSMICG00000006401.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857348"/>
    <dbReference type="KEGG" id="mmur:105857348"/>
    <dbReference type="CTD" id="341208"/>
    <dbReference type="GeneTree" id="ENSGT00940000157994"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04222">
        <property type="entry name" value="CuRO_1_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11021">
        <property type="entry name" value="CuRO_2_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04224">
        <property type="entry name" value="CuRO_3_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11022">
        <property type="entry name" value="CuRO_4_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000009">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000002">
        <property type="entry name" value="Hephaestin like 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024715">
        <property type="entry name" value="Factor_5/8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF233">
        <property type="entry name" value="FERROXIDASE HEPHL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000354">
        <property type="entry name" value="Factors_V_VIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150261" description="ferroxidase" evidence="19">
        <location>
            <begin position="25"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1119"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="99"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="316"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="456"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="810"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="964"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1077"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="285"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="638"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000354-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005844.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1164" mass="131809" checksum="E659F0609015D8E2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XCG1</accession>
    <name>A0A8C5XCG1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ephexin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Eph-interacting exchange protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Neuronal guanine nucleotide exchange factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">NGEF</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010636">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012647058.1">
        <property type="nucleotide sequence ID" value="XM_012791604.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143712.1">
        <property type="nucleotide sequence ID" value="XM_020288123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XCG1"/>
    <dbReference type="Ensembl" id="ENSMICT00000006735.3">
        <property type="protein sequence ID" value="ENSMICP00000006142.3"/>
        <property type="gene ID" value="ENSMICG00000006727.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105886151"/>
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    <dbReference type="CTD" id="25791"/>
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    <sequence length="709" mass="81924" checksum="E1C067D60CB8F9AE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="9">FAM3 metabolism regulating signaling molecule B</fullName>
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        <name evidence="9" type="primary">FAM3B</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the FAM3 family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GG_LECTIN"/>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011229.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="237" mass="25947" checksum="4C39A0C3CAD50F06" modified="2022-01-19" version="1">MGSSPGFFGAFKAGLLVFASLCAWYGGYLLAELIPDTSLSSAVYNIRSIGKKPVLKAPAPKRQKCDHWTACPPDTYAYRLLSGGGRNNFAKVCFEDELLIGQKTGGASRGINIAIVNYVTGKVIATQCFDMYEGDNSGPMTRFIQSAPPKSLLLMVTHDDGSTRLTEDAKKAIEALGSKEIRNMRFRSSWVFLAAKGFELPAGIQREKINHSNDKKNRYSGWPAEIQIEGCLPREPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XFT4</accession>
    <name>A0A8C5XFT4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial import receptor subunit TOM34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Translocase of outer membrane 34 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TOMM34</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with HSP90A, VCP, ATP6V1D, KIAA0665, AMPK, and DMAP1 through its TPR repeat.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Tom34 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636058.1">
        <property type="nucleotide sequence ID" value="XM_012780604.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XFT4"/>
    <dbReference type="Ensembl" id="ENSMICT00000033408.2">
        <property type="protein sequence ID" value="ENSMICP00000017972.1"/>
        <property type="gene ID" value="ENSMICG00000032653.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879934"/>
    <dbReference type="KEGG" id="mmur:105879934"/>
    <dbReference type="CTD" id="10953"/>
    <dbReference type="GeneTree" id="ENSGT00940000161058"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000221">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000312">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF2">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="309" mass="34739" checksum="FB09A7394E4D6DDA" modified="2022-01-19" version="1">MAPKHPESVESLRAAGNASFRNGQYAEASALYCRALRALQARGSSDPGEESVLYSNRAACHFKDGNCRDCIKDCTSALALVPFSLKPLLRRASAYEALEKYHLAYVDYKTVLQIDENVTPALEGINRMTRALMDSLGPEWRQKLPSIPVVPVSSQKRWTASSWEKHKETAKKISKETTATKSRVPSAGNAERARVLKEEGNELVKKGNHKKAVEKYTESLLYSNQESATYSNRALCYLALKQYREAVKDCTEALKLDGRNVKAFYRRAQAYKALKDYKSSFADINNLLQIEPRNGPAQKLRQELKQNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XG49</accession>
    <name>A0A8C5XG49_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Disheveled-associated activator of morphogenesis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DAAM1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Together with DAAM2, required for myocardial maturation and sarcomere assembly. During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XG49"/>
    <dbReference type="Ensembl" id="ENSMICT00000039728.2">
        <property type="protein sequence ID" value="ENSMICP00000018960.2"/>
        <property type="gene ID" value="ENSMICG00000012461.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156452"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 1"/>
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        <property type="entry name" value="GBD_FH3"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="GBD/FH3" evidence="15">
        <location>
            <begin position="45"/>
            <end position="420"/>
        </location>
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    <feature type="domain" description="FH2" evidence="16">
        <location>
            <begin position="600"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="14">
        <location>
            <begin position="1032"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="524"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1062"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="438"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="548"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00069157"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS51231"/>
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    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
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        <source>
            <dbReference type="PROSITE" id="PS51444"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018960.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1083" mass="123994" checksum="1B8B6CDCF43F0313" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJD3</accession>
    <name>A0A8C5XJD3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 235</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF235</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026725">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026726">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026727">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616790.1">
        <property type="nucleotide sequence ID" value="XM_012761336.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616791.1">
        <property type="nucleotide sequence ID" value="XM_012761337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJD3"/>
    <dbReference type="Ensembl" id="ENSMICT00000037260.2">
        <property type="protein sequence ID" value="ENSMICP00000028650.1"/>
        <property type="gene ID" value="ENSMICG00000004971.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105869492"/>
    <dbReference type="CTD" id="9310"/>
    <dbReference type="GeneTree" id="ENSGT00940000162402"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000726">
        <property type="entry name" value="Zinc finger protein 214"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000874">
        <property type="entry name" value="zinc finger protein 235 isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000913">
        <property type="entry name" value="zinc finger protein 235 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001049">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001700">
        <property type="entry name" value="Zinc finger protein 677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002357">
        <property type="entry name" value="Zinc finger protein 782"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF107">
        <property type="entry name" value="ZFP2 ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="14">N-acetylneuraminate (7)9-O-acetyltransferase</fullName>
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            <fullName evidence="16">Sialate O-acetyltransferase</fullName>
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        <name evidence="21" type="primary">CASD1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <reaction evidence="11">
            <text>CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-7-O-acetyl-beta-neuraminate + CoA</text>
            <dbReference type="Rhea" id="RHEA:79555"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:229976"/>
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        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:79556"/>
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        <reaction evidence="12">
            <text>CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-9-O-acetyl-beta-neuraminate + CoA</text>
            <dbReference type="Rhea" id="RHEA:81827"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
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            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:229947"/>
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            <dbReference type="Rhea" id="RHEA:81828"/>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a ganglioside GD3 (d18:1(4E)) + acetyl-CoA = a ganglioside Ac-O-7-GD3(d18:1(4E)) + CoA</text>
            <dbReference type="Rhea" id="RHEA:79499"/>
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            <dbReference type="ChEBI" id="CHEBI:78436"/>
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            <dbReference type="Rhea" id="RHEA:79500"/>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
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        <property type="entry name" value="Cas1_AcylTrans_dom"/>
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        <property type="entry name" value="Cyclin-like_sf"/>
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        <property type="entry name" value="NXPE4_C"/>
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        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDAH family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002716">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002717">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603012.1">
        <property type="nucleotide sequence ID" value="XM_012747558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XL36"/>
    <dbReference type="Ensembl" id="ENSMICT00000033545.2">
        <property type="protein sequence ID" value="ENSMICP00000033401.1"/>
        <property type="gene ID" value="ENSMICG00000015756.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861776"/>
    <dbReference type="CTD" id="23576"/>
    <dbReference type="GeneTree" id="ENSGT00940000157892"/>
    <dbReference type="OrthoDB" id="10016839at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016403">
        <property type="term" value="F:dimethylargininase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000052">
        <property type="term" value="P:citrulline metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:L-arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900038">
        <property type="term" value="P:negative regulation of cellular response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043116">
        <property type="term" value="P:negative regulation of vascular permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003073">
        <property type="term" value="P:regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000004">
        <property type="entry name" value="N(G),N(G)-dimethylarginine dimethylaminohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033199">
        <property type="entry name" value="DDAH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737">
        <property type="entry name" value="DIMETHYLARGININE DIMETHYLAMINOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12737:SF17">
        <property type="entry name" value="N(G),N(G)-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19420">
        <property type="entry name" value="DDAH_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="78"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633199-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="285" mass="31213" checksum="E0E9CA66BC8E067A" modified="2022-01-19" version="1">MAGLGQAATFGRATHAVVRALPESLAQQALRSTKGEEVDFARAERQHQLYVGVLGSKLGLQVVELPAEESLPDCVFVEDVAVVCEETALITRPGASSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVTDTLHLKSFCSMAGPNLIAIGSSEPAQKALKIMQQMSDHRYDKLTVPDDKAANCIYLNIPSKGHILLHRTPEEYPESAKVYEKLKDHLLIPVSNSELEKVDGLLTCCSVLINKKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XLG7</accession>
    <name>A0A8C5XLG7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Spire type actin nucleation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SPIRE1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the spire family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023091">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XLG7"/>
    <dbReference type="Ensembl" id="ENSMICT00000042707.2">
        <property type="protein sequence ID" value="ENSMICP00000034865.2"/>
        <property type="gene ID" value="ENSMICG00000000131.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003058"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036089">
        <property type="term" value="P:cleavage furrow formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051295">
        <property type="term" value="P:establishment of meiotic spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070649">
        <property type="term" value="P:formin-nucleated actin cable assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040038">
        <property type="term" value="P:polar body extrusion after meiotic divisions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000781">
        <property type="term" value="P:positive regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15767">
        <property type="entry name" value="FYVE_SPIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22186">
        <property type="entry name" value="WH2_Spire1-2_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22078">
        <property type="entry name" value="WH2_Spire1_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22080">
        <property type="entry name" value="WH2_Spire1_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22065">
        <property type="entry name" value="WH2_Spire_1-2_r1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000455">
        <property type="entry name" value="protein spire homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KIND_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029905">
        <property type="entry name" value="Spir-1_FYVE-rel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029901">
        <property type="entry name" value="Spire"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345:SF8">
        <property type="entry name" value="PROTEIN SPIRE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21345">
        <property type="entry name" value="SPIRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16474">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00750">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51377">
        <property type="entry name" value="KIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KIND" evidence="15">
        <location>
            <begin position="32"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="450"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034865.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="749" mass="84759" checksum="3D927B84CDE2EF6E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XLH8</accession>
    <name>A0A8C5XLH8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase F(1) complex subunit gamma, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP synthase F1 subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with FLVCR2; this interaction occurs in the absence of heme and is disrupted upon heme binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XLH8"/>
    <dbReference type="Ensembl" id="ENSMICT00000041874.2">
        <property type="protein sequence ID" value="ENSMICP00000034958.2"/>
        <property type="gene ID" value="ENSMICG00000035619.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006837"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034958.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="242" mass="26547" checksum="C9B67C7CDDEE6F2C" modified="2022-01-19" version="1">MFSAAVGALQPQWVQVRNMATLKDITRRLNSTRNIQKITKSMKMVAAGKHVCGIGSLALYGKADIKVPEDKKKHLLIGVSSDRGLCGAIHFSVAKQMKSEVATLTVARKEVMIVGIGNKIRGILHRTCSDQFLVTFKEVGSALVIALELLNSGYEFYEDSFIFNRFRSVISFKTEGKPIFSPNIIASESTTCEQSARITAKDNASKNASEMIDKLTFTFNRTHQAVITKELIEITSGAAAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XMM1</accession>
    <name>A0A8C5XMM1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rab-interacting lysosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RILP</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with RAB7A. Interacts with RAB34. Identified in a complex with MREG and DCTN1; interacts directly with MREG. Interacts with CLN3. Interacts with FLCN; the interaction is direct and promotes association between RILP and RAB34.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XMM1"/>
    <dbReference type="Ensembl" id="ENSMICT00000050251.2">
        <property type="protein sequence ID" value="ENSMICP00000037768.1"/>
        <property type="gene ID" value="ENSMICG00000034729.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161117"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032509">
        <property type="term" value="P:endosome transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070676">
        <property type="term" value="P:intralumenal vesicle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000004">
        <property type="entry name" value="Rab interacting lysosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF7">
        <property type="entry name" value="RAB-INTERACTING LYSOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0458">Lysosome</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="17">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="18">
        <location>
            <begin position="239"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="303"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="404" mass="44630" checksum="A43E1D5FFE35122A" modified="2022-01-19" version="1">MEPRRAAPGAHGWGPVAAGSGTSAELVYHLAGALGTELQELARRFGPEAAAGLVPLVVRALELLEKAAVGPAPDSLQVSAQQAELELRRLREENEHLRRELRAGPQEERELLRQLKEVTDRQRDELRAHNRDLQQRSQETEALQEQLQRLLLVNAELRRKLAAVQTQLRATQDREREREQLGEGALEPAKERARGRAGGLGCEQRQEPERAAISTGASGTPEDPAAATQQPWRPSDAGQCGFSREELEQILQERNELKANVFLLKEELAYFQRELLTDHRVPGLLLEAMKVAVRKQRKKIKAKMLGTTEEAESSDDEDGSWLLLTSDKGDHPPAPESRIQSFFGSWYRGEAEAPEAETSSGAPSKLGRKEEASWKPHSEPVAPDQPCSAPDEHLCLGASTAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNN2</accession>
    <name>A0A8C5XNN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methylcytosine dioxygenase TET</fullName>
            <ecNumber evidence="11">1.14.11.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TET2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 5-formyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + succinate + CO2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53832"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="Rhea" id="RHEA-COMP:13657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="ChEBI" id="CHEBI:137732"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a 5-hydroxymethyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-formyl-2'-deoxycytidine in DNA + succinate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:53828"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="Rhea" id="RHEA-COMP:13656"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="ChEBI" id="CHEBI:137731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5-methyl-2'-deoxycytidine in DNA + 2-oxoglutarate + O2 = a 5-hydroxymethyl-2'-deoxycytidine in DNA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:52636"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="Rhea" id="RHEA-COMP:13315"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="ChEBI" id="CHEBI:136731"/>
            <dbReference type="EC" id="1.14.11.80"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">The zinc ions have a structural role.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TET family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.80" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03030270">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000047507.2">
        <property type="protein sequence ID" value="ENSMICP00000038361.2"/>
        <property type="gene ID" value="ENSMICG00000035595.2"/>
    </dbReference>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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        <text evidence="15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER. The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER. Binds the signal recognition particle RNA (7SL RNA) in presence of SRP68. Can bind 7SL RNA with low affinity. The SRP complex possibly participates in the elongation arrest function.</text>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038483.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="663" mass="74051" checksum="732C91E8921E26D4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNY8</accession>
    <name>A0A8C5XNY8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAP3K12 binding inhibitory protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MBIP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622489.1">
        <property type="nucleotide sequence ID" value="XM_012767035.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNY8"/>
    <dbReference type="Ensembl" id="ENSMICT00000039145.2">
        <property type="protein sequence ID" value="ENSMICP00000038566.1"/>
        <property type="gene ID" value="ENSMICG00000013161.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872765"/>
    <dbReference type="CTD" id="51562"/>
    <dbReference type="GeneTree" id="ENSGT00510000047831"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="344" mass="38862" checksum="497CEF644EE9C982" modified="2022-01-19" version="1">MAAATELSRPNSGDRSLERSCSPSLSREVLCEVFRSLHALPGKLSLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQPLIKEENTTACEDIGKTDMGNKNEINTKFSIGDLQEEEKHKDCDLGDVKKTQIHFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAVFTPYPGFKSHVKVSRVVNTYGPQTRPEGIQGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVNFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSREADSMATHHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTQ8</accession>
    <name>A0A8C5XTQ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Abasic site processing protein HMCES</fullName>
            <shortName evidence="12">ES cell-specific 5hmC-binding protein</shortName>
            <ecNumber evidence="12">3.4.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 12">Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 12">Peptidase HMCES</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">SRAP domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HMCES</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then either reversed or degraded. HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites. The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase. Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03025451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTQ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000071108.1">
        <property type="protein sequence ID" value="ENSMICP00000040897.1"/>
        <property type="gene ID" value="ENSMICG00000042693.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018439"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="entry name" value="SOS response associated peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604:SF0">
        <property type="entry name" value="ABASIC SITE PROCESSING PROTEIN HMCES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="DC12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="BB1717-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="247" mass="26971" checksum="BA48F13C9CEC34E8" modified="2022-01-19" version="1">EADPSERVIAPMRWGLVPSWFKERDPRSLQFNTTNCRSDTILEKRSFKSGGGGGPQHGLGDREVVWENWRPLTMAGVFDCWEPPEGGDALYSFSIITVDSCHALSDIHHRMPAILDGEAAVSQWLDFGGVPTQEAMRLIRPTENVAFHPVSTVVNNSRNDTPECLAPVDLAVKKEPTAGGGALLRWLATKSPGTEDPASPRRGRPDVPQGSSQFLRGGASPPRLGGAGLLRRWLKRETEAEDEPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUM7</accession>
    <name>A0A8C5XUM7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Immunoglobulin V-set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUM7"/>
    <dbReference type="Ensembl" id="ENSMICT00000063588.1">
        <property type="protein sequence ID" value="ENSMICP00000041407.1"/>
        <property type="gene ID" value="ENSMICG00000047169.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244871"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001259">
        <property type="entry name" value="Immunoglobulin heavy variable 13-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Immunoglobulin V-set" evidence="9">
        <location>
            <begin position="17"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="102" mass="10922" checksum="A5F654849285D76A" modified="2022-01-19" version="1">EVQLVESGGGLAQPGGSLRLSCAASGFTFSDYYMNWVRQAPGKGLEWVGVIRNKANGGTAEYAASVKGRFTISRDDSKSTAYLQMNSLRAEDTAFSLLTTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y105</accession>
    <name>A0A8C5Y105_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 684</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF684</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001726">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135895.1">
        <property type="nucleotide sequence ID" value="XM_020280306.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135897.1">
        <property type="nucleotide sequence ID" value="XM_020280308.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135899.1">
        <property type="nucleotide sequence ID" value="XM_020280310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y105"/>
    <dbReference type="Ensembl" id="ENSMICT00000068295.1">
        <property type="protein sequence ID" value="ENSMICP00000044071.1"/>
        <property type="gene ID" value="ENSMICG00000044852.1"/>
    </dbReference>
    <dbReference type="CTD" id="127396"/>
    <dbReference type="GeneTree" id="ENSGT00940000163099"/>
    <dbReference type="OrthoDB" id="6052214at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003729">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000638">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000650">
        <property type="entry name" value="Zinc finger protein 197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000725">
        <property type="entry name" value="zinc finger protein 205 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001126">
        <property type="entry name" value="zinc finger protein 684 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="378" mass="44136" checksum="F16F88C8D399178B" modified="2022-01-19" version="1">MINFQESVTFQDVAVDFTLEEWQLLDCAERTLYWDVMLENYRNLISVGCPVSKTKVIFRVEQGQEPWMVEGGNSCWSHPEADCPLVDEPEKQEENKDNFLTSVLFTFNKILTMERIHRYNMSTSLNPTRKKSYKPHRRSVQPNLDFLNYKRSYCGKNSCECCECEKDFKKKFHFIRHETNHTRKRPFECNDCGKAYSRKGHLATHQKIHNGERPFVCSDCGKAFMHKAQLVVHQRLHTGEKPYECSQCGKTFTWSSSFNQHVKSHTLENSFECKECGKTFRYSSSLYKHSRFHTGEKPYRCIICGKAFGNTSVLVTHQRIHTGEKPYGCIECGKAFIKKSHLLRHQITHTGEKPYECNKCGKAFSQKSNLIVHQKIHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y5R2</accession>
    <name>A0A8C5Y5R2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFA2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 14">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Mitochondrion inner membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022490">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604407.1">
        <property type="nucleotide sequence ID" value="XM_012748953.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y5R2"/>
    <dbReference type="Ensembl" id="ENSMICT00000060162.1">
        <property type="protein sequence ID" value="ENSMICP00000046220.1"/>
        <property type="gene ID" value="ENSMICG00000047730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105862566"/>
    <dbReference type="CTD" id="4695"/>
    <dbReference type="GeneTree" id="ENSGT00390000006178"/>
    <dbReference type="OMA" id="RIHLCQH"/>
    <dbReference type="OrthoDB" id="10250268at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001835">
        <property type="term" value="P:blastocyst hatching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000127">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016464">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12878">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B8 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005822">
        <property type="entry name" value="NDUA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="15">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR005822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR005822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="99" mass="10981" checksum="9D786E77C8176BD8" modified="2022-01-19" version="1">MAAAAAVRGIGAKLGLREIRIHLCQRSPGSQGVRDFIEKRYVELKKANPDLPILIRECSDVQPKLWARYAFGQEKNVSLNNFSADQVTRTVENVLSGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y6Q4</accession>
    <name>A0A8C5Y6Q4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Sulfotransferase</fullName>
            <ecNumber evidence="14">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HS3ST3B1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="14"/>
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                <person name="Liu Y."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="30"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047579.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="177" mass="17745" checksum="7D6F7F924B233840" modified="2022-01-19" version="1">RSRTEKREGPQVMAPAGRVPGRLPGLPSPALCCACGLCVLLAGVNVTLVGAFASFLPGHNAPLVVGPALLVLALGFFAACCLCSRRGPARRARSLAAADPGQGGGRAGPVALEMESSERTAQDTTAVQLSPAVSAASSGRSSPGPDAFALDAPAPAAVCALRTEGLQLNLPRERAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YA39</accession>
    <name>A0A8C5YA39_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03018511">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018512">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061407.1">
        <property type="protein sequence ID" value="ENSMICP00000048589.1"/>
        <property type="gene ID" value="ENSMICG00000045779.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234646"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.20:FF:000001">
        <property type="entry name" value="[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF14">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE ISOZYME 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="9">
        <location>
            <begin position="46"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="401" mass="46213" checksum="C982CB9B43DE70B2" modified="2022-01-19" version="1">MNFFFRHIRCSLPRPALPACDSPVSMASLVSGGSGLFPYARFSPSPLSMKQFLDFGSVDACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAVYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKDKGSPSHRKHIGSINPNCNVVEVIKDGYENARRLCDLYYVNSPELELGELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEYHADQGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRXXXXVSIYLQMFLILATRWLLIFPFFSFFPQALSTESMKRLRVQQAAWKHYNTNHETMTTFRSARYAWDTWETQMWFSYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAK8</accession>
    <name>A0A8C5YAK8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MGAT4 conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC105860062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 54 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029854">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029856">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAK8"/>
    <dbReference type="Ensembl" id="ENSMICT00000068565.1">
        <property type="protein sequence ID" value="ENSMICP00000047770.1"/>
        <property type="gene ID" value="ENSMICG00000026876.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163241"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF32">
        <property type="entry name" value="MGAT4 FAMILY, MEMBER F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="6">
        <location>
            <begin position="96"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="508" mass="57762" checksum="B5312FF2BEABC768" modified="2022-01-19" version="1">MGTMKWQASRQQENIPMLSEWDAARIHNQLTFLCRVAPGPRTMHCSLWRCIIVAVSLVLLGFIFQENKEEHVEYHVSVKEKKEVIWKAVQEQISSERKNHLETFKEMQQRAPLLQHAKYRFLAGAPPQQKKLLTVGISSMQPPGGSHLLDTLRSVFEASSEPEWRSIVVLVHLSDPDPEWLNQTAANISRLFAPHIEARELLVIHGLLGGSPVPGNLSDTNHTSPCEALYSRQKVDYALLMNFASSLSDYFLLMEDHVHCSPKFVSAIYWALSAWEELPWVTLEFSSLNMSGKVFRSSDLSRLTSFFLLFLNTPAPLLLSEFRLLLAQDVPIRFTPSLFSHVGVSSTVEDSCFPVEKEQDFDEPDNPTATVVTDMEVFLDLISQYAYTLNQEDFSTLDLLKGNHLTVIMDRPQKVIRIAVLTGLNEGERYRLQQGQVELGYDPIEEPKGCAHYTLLGPLVQGNLDQRVFSEEDSEKVSCIRLLVLASQKGWVLIRQIRVWTQPEEEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YCK3</accession>
    <name>A0A8C5YCK3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">R-spondin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Roof plate-specific spondin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RSPO2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the R-spondin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013316">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641774.1">
        <property type="nucleotide sequence ID" value="XM_012786320.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641775.1">
        <property type="nucleotide sequence ID" value="XM_012786321.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YCK3"/>
    <dbReference type="Ensembl" id="ENSMICT00000070343.1">
        <property type="protein sequence ID" value="ENSMICP00000048317.1"/>
        <property type="gene ID" value="ENSMICG00000010503.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883271"/>
    <dbReference type="KEGG" id="mmur:105883271"/>
    <dbReference type="CTD" id="340419"/>
    <dbReference type="GeneTree" id="ENSGT00940000159194"/>
    <dbReference type="OrthoDB" id="10257656at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035116">
        <property type="term" value="P:embryonic hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060441">
        <property type="term" value="P:epithelial tube branching involved in lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060437">
        <property type="term" value="P:lung growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042489">
        <property type="term" value="P:negative regulation of odontogenesis of dentin-containing tooth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060535">
        <property type="term" value="P:trachea cartilage morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00064">
        <property type="entry name" value="FU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000028">
        <property type="entry name" value="R-spondin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.220.10:FF:000012">
        <property type="entry name" value="R-spondin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.220.10">
        <property type="entry name" value="Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006212">
        <property type="entry name" value="Furin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051514">
        <property type="entry name" value="R-spondin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043601">
        <property type="entry name" value="Rspo_Fu-CRD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987">
        <property type="entry name" value="NEUROHYPOPHYSIAL HORMONES, N-TERMINAL DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46987:SF4">
        <property type="entry name" value="R-SPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15913">
        <property type="entry name" value="Furin-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00261">
        <property type="entry name" value="FU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="8 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150536" description="R-spondin-2" evidence="14">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="R-spondin Fu-CRD" evidence="15">
        <location>
            <begin position="40"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Spondin-like TSP1" evidence="16">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074432"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00075541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF19028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="243" mass="28229" checksum="8B40406986A0FD00" modified="2022-01-19" version="1">MQFRLFSFALIILNCMDYSHCQGNRWRRSKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMTMRHCPGGKRTPKAKEKKNKKKKRKLIERAQEQHSVFLATDRANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YCZ8</accession>
    <name>A0A8C5YCZ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03010560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YCZ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000065383.1">
        <property type="protein sequence ID" value="ENSMICP00000049926.1"/>
        <property type="gene ID" value="ENSMICG00000042660.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01140000282628"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034022747" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8279" checksum="D0980EDCBE05B063" modified="2022-01-19" version="1">MWPLTPPVVLLVSFLLVRPWPPAPLFFSVRWKMDGTAVGLSSRCWSSSLLEKLSLVKCSLQRNEYFVGVQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEA6</accession>
    <name>A0A8C5YEA6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ATE1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03019505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019506">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEA6"/>
    <dbReference type="Ensembl" id="ENSMICT00000059788.1">
        <property type="protein sequence ID" value="ENSMICP00000049725.1"/>
        <property type="gene ID" value="ENSMICG00000009823.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044926"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="293"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="520" mass="59670" checksum="F0606BBE2A928877" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGJ7</accession>
    <name>A0A8C5YGJ7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein kinase OSR1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Oxidative stress-responsive 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">OXSR1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03000475">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611845.1">
        <property type="nucleotide sequence ID" value="XM_012756391.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGJ7"/>
    <dbReference type="Ensembl" id="ENSMICT00000073444.1">
        <property type="protein sequence ID" value="ENSMICP00000051152.1"/>
        <property type="gene ID" value="ENSMICG00000049561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866809"/>
    <dbReference type="KEGG" id="mmur:105866809"/>
    <dbReference type="CTD" id="9943"/>
    <dbReference type="GeneTree" id="ENSGT00940000162134"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019870">
        <property type="term" value="F:potassium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071476">
        <property type="term" value="P:cellular hypotonic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038116">
        <property type="term" value="P:chemokine (C-C motif) ligand 21 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038146">
        <property type="term" value="P:chemokine (C-X-C motif) ligand 12 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901380">
        <property type="term" value="P:negative regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007231">
        <property type="term" value="P:osmosensory signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010820">
        <property type="term" value="P:positive regulation of T cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070294">
        <property type="term" value="P:renal sodium ion absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000043">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000068">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE OSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="17"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="527" mass="58062" checksum="4C40DCD30DBDA249" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHJ6</accession>
    <name>A0A8C5YHJ6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein O-glucosyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">POGLUT1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001106">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636037.1">
        <property type="nucleotide sequence ID" value="XM_012780583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHJ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000072365.1">
        <property type="protein sequence ID" value="ENSMICP00000051045.1"/>
        <property type="gene ID" value="ENSMICG00000048901.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879924"/>
    <dbReference type="KEGG" id="mmur:105879924"/>
    <dbReference type="CTD" id="56983"/>
    <dbReference type="GeneTree" id="ENSGT00940000158283"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048318">
        <property type="term" value="P:axial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072359">
        <property type="term" value="P:circulatory system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060537">
        <property type="term" value="P:muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048339">
        <property type="term" value="P:paraxial mesoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045747">
        <property type="term" value="P:positive regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010470">
        <property type="term" value="P:regulation of gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150579" evidence="4">
        <location>
            <begin position="24"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="121"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="392" mass="45978" checksum="9188017838DAEF63" modified="2022-01-19" version="1">MEPGKSSPLRLWLLLLLLPPVQGRQKESGSKWKVFIDQINRSLENYEPCSSQNCGCYHGVIEEDLMPFRGGISRKMMAEVVRRKLGTHYQIIKNKLYRENDCMFPSRCSGVEHFILEVIGRLPDMEMVINVRDYPQVPKWMEPAIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPIYPTGLGRWDLFREDLIRSAAQWPWKMKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLVDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWLEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDVAQEIAERGSQFIMNHLQMDDITCYWESLLTEYSKFLSYNVTRRKGYDQIIPKNLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EAK0</accession>
    <name>A0A8B7EAK0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nuclear transcription factor Y subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CAAT box DNA-binding protein subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Nuclear transcription factor Y subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NFYC</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001726">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591262.1">
        <property type="nucleotide sequence ID" value="XM_012735808.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591264.1">
        <property type="nucleotide sequence ID" value="XM_012735810.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591265.1">
        <property type="nucleotide sequence ID" value="XM_012735811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EAK0"/>
    <dbReference type="Ensembl" id="ENSMICT00000047179.2">
        <property type="protein sequence ID" value="ENSMICP00000019473.1"/>
        <property type="gene ID" value="ENSMICG00000004285.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855083"/>
    <dbReference type="CTD" id="4802"/>
    <dbReference type="GeneTree" id="ENSGT00940000155689"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000006">
        <property type="entry name" value="Nuclear transcription factor Y subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="288"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="439" mass="48184" checksum="8E0D289DA89A6AD6" modified="2022-01-19" version="1">MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKMISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPRDELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIIIAQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIPVQLNASQLQYIRLAQPVSGTQVVQGQIQTLATNAQQITQTEVQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKSTGNSTPCTSSLPTTHPPSHRAGASCVCCSQPQQSSTSPPPSDAMQWVVVEVSGTPNQLEAHRELHAPLPGMTSLSPLHPSQQLYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDU9</accession>
    <name>A0A8B7EDU9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC105855229</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03020950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020951">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591541.1">
        <property type="nucleotide sequence ID" value="XM_012736087.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EDU9"/>
    <dbReference type="Ensembl" id="ENSMICT00000000215.3">
        <property type="protein sequence ID" value="ENSMICP00000000194.2"/>
        <property type="gene ID" value="ENSMICG00000000215.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855229"/>
    <dbReference type="GeneTree" id="ENSGT00940000163352"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM2A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM5, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF3">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE ACSM2B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="59"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="17">
        <location>
            <begin position="478"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="578" mass="64424" checksum="02F72B4767E1D156" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EFD0</accession>
    <name>A0A8B7EFD0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U11/U12 small nuclear ribonucleoprotein 25 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SNRNP25</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593218.1">
        <property type="nucleotide sequence ID" value="XM_012737764.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EFD0"/>
    <dbReference type="Ensembl" id="ENSMICT00000032659.2">
        <property type="protein sequence ID" value="ENSMICP00000040079.1"/>
        <property type="gene ID" value="ENSMICG00000036732.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856251"/>
    <dbReference type="KEGG" id="mmur:105856251"/>
    <dbReference type="CTD" id="79622"/>
    <dbReference type="GeneTree" id="ENSGT00390000002628"/>
    <dbReference type="OrthoDB" id="72819at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17058">
        <property type="entry name" value="Ubl_SNRNP25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000194">
        <property type="entry name" value="U11/U12 small nuclear ribonucleoprotein 25 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039690">
        <property type="entry name" value="SNRNP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040610">
        <property type="entry name" value="SNRNP25_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942">
        <property type="entry name" value="U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14942:SF0">
        <property type="entry name" value="U11_U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 25 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18036">
        <property type="entry name" value="Ubiquitin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SNRNP25 ubiquitin-like" evidence="9">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="171" mass="19351" checksum="9898172876B979E2" modified="2022-01-19" version="1">MPAEPGQGLATLEEAEAAGRLEAPQDDEDEEEALPHSEAVDVFQEGLAMVVQDPLLCDLPIQVTLEEVNSQIALEYGQAMTVRVCKMDGEVMPVVVVQNATVLDLKKAIQRYVQLKQEREGGIQHISWSYVWRTYHLTSAGEKLTEDRKKLRDYGIRNRDEVSFIKKLRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EIG2</accession>
    <name>A0A8B7EIG2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Putative E3 ubiquitin-protein ligase UBR7</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-recognin-7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase UBR7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">UBR7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03003487">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003488">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594043.1">
        <property type="nucleotide sequence ID" value="XM_012738589.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EIG2"/>
    <dbReference type="Ensembl" id="ENSMICT00000031173.2">
        <property type="protein sequence ID" value="ENSMICP00000033900.1"/>
        <property type="gene ID" value="ENSMICG00000000784.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856746"/>
    <dbReference type="CTD" id="55148"/>
    <dbReference type="GeneTree" id="ENSGT00390000017610"/>
    <dbReference type="OrthoDB" id="10262564at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15542">
        <property type="entry name" value="PHD_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19677">
        <property type="entry name" value="UBR-box_UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000183">
        <property type="entry name" value="putative E3 ubiquitin-protein ligase UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040204">
        <property type="entry name" value="UBR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047506">
        <property type="entry name" value="UBR7-like_UBR-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13513:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="17">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="16">
        <location>
            <begin position="44"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00071060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="425" mass="48158" checksum="AB55E36F99B4825B" modified="2022-01-19" version="1">MAGAEGSAGRHSELEPVVSLVDVLEEDEELENEACAVLGGSDSEKCSYSQGSVKRQALYACSTCTPEGEEPAGICLACSYECHGSHKLFELYTKRNFRCDCGNSKFKNLECKLFPDKAKVNSGNKYNENFFGLYCVCKRPYPDPEDEIPDEMIQCVVCEDWFHGRHLGATPPESGDFQEMVCQACMKRCSFLWAYAAQWAVTKISAEDDALVRNVDGIGDQDVTKAENGNHQDGTLKEDVPEHGKDAIKEVKAEQNNEPCTSSSSESDLQTVFKNQSLNTESQSGCKLLELKAKQFIKKDTATYWPLNWRSKLCTCQDCMKMYGDLDVLFLTDEYDTVLAYENKGKIDQATDRRDPLMDTLNSMNRVQQVELICEYNDLKTELKDYLKRFADEGTVVKREDIQQFFEEFQSKKRRRVDGVQYYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ERK4</accession>
    <name>A0A8B7ERK4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small integral membrane protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SMIM9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03035485">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035486">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597736.1">
        <property type="nucleotide sequence ID" value="XM_012742282.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ERK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000061979.1">
        <property type="protein sequence ID" value="ENSMICP00000046376.1"/>
        <property type="gene ID" value="ENSMICG00000043321.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105858884"/>
    <dbReference type="KEGG" id="mmur:105858884"/>
    <dbReference type="CTD" id="100132963"/>
    <dbReference type="GeneTree" id="ENSGT00390000005685"/>
    <dbReference type="OrthoDB" id="9537610at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038853">
        <property type="entry name" value="Smim9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41687">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41687:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133422" evidence="2">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="99" mass="10928" checksum="580AFDEEC642E338" modified="2022-01-19" version="1">MEPQKLLSLGFLLCSLTCLLLELVASSPSPLSALRIQEKAGSKPRSRDNYRAWLSNFRDYLWDLIKSSIPPAAIFAFLITTALMGTLCCLTILVGEPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ET00</accession>
    <name>A0A8B7ET00_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC105858694</name>
        <name evidence="16" type="synonym">LOC105858732</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018500">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597460.1">
        <property type="nucleotide sequence ID" value="XM_012742006.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597518.1">
        <property type="nucleotide sequence ID" value="XM_012742064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ET00"/>
    <dbReference type="SMR" id="A0A8B7ET00"/>
    <dbReference type="Ensembl" id="ENSMICT00000066470.1">
        <property type="protein sequence ID" value="ENSMICP00000048494.1"/>
        <property type="gene ID" value="ENSMICG00000044377.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069674.1">
        <property type="protein sequence ID" value="ENSMICP00000049954.1"/>
        <property type="gene ID" value="ENSMICG00000047263.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105858694"/>
    <dbReference type="GeneID" id="105858732"/>
    <dbReference type="KEGG" id="mmur:105858694"/>
    <dbReference type="KEGG" id="mmur:105858732"/>
    <dbReference type="GeneTree" id="ENSGT01150000286957"/>
    <dbReference type="OMA" id="AQLCQTT"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000003">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="126" mass="13934" checksum="E9506F3DCE96C106" modified="2022-01-19" version="1">MPEPAKSAPAPKKGSKKAVTKVQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F124</accession>
    <name>A0A8B7F124_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">UBE2E1</name>
        <name evidence="12" type="synonym">LOC105860526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03000150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F124"/>
    <dbReference type="SMR" id="A0A8B7F124"/>
    <dbReference type="Ensembl" id="ENSMICT00000073133.1">
        <property type="protein sequence ID" value="ENSMICP00000051363.1"/>
        <property type="gene ID" value="ENSMICG00000048911.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105860526"/>
    <dbReference type="KEGG" id="mmur:105860526"/>
    <dbReference type="GeneTree" id="ENSGT00940000156415"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042296">
        <property type="term" value="F:ISG15 transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032020">
        <property type="term" value="P:ISG15-protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23793">
        <property type="entry name" value="UBCc_UBE2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000003">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="11">
        <location>
            <begin position="47"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="193" mass="21404" checksum="2FBC50BE2A6A0008" modified="2022-01-19" version="1">MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADITLDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIYHCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEHDRMARQWTKRYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6I3</accession>
    <name>A0A8B7F6I3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">MED9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603385.1">
        <property type="nucleotide sequence ID" value="XM_012747931.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6I3"/>
    <dbReference type="Ensembl" id="ENSMICT00000047704.2">
        <property type="protein sequence ID" value="ENSMICP00000029726.1"/>
        <property type="gene ID" value="ENSMICG00000031510.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105861981"/>
    <dbReference type="KEGG" id="mmur:105861981"/>
    <dbReference type="CTD" id="55090"/>
    <dbReference type="GeneTree" id="ENSGT00390000017379"/>
    <dbReference type="OrthoDB" id="5950777at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21431">
        <property type="entry name" value="Med9-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039242">
        <property type="entry name" value="MED9_metazoa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20844">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="147" mass="16456" checksum="4D8EDC6B1AF7ECB8" modified="2022-01-19" version="1">MASAGVAAGRQAEDALPPSSEPPLPDTKPLPPPQQPPPVAAPQPQQSPAPRPQSPARVREEENYSFLPLVHSIIKCMDKDSPDVHQDLNALKTKFQEMRKLISTMPGIHLSPEQQQQQLHSLREQVRTKNELLQKYKSLCMFEIPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F756</accession>
    <name>A0A8B7F756_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vasoactive intestinal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">VIP</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles. Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glucagon family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008590">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603608.1">
        <property type="nucleotide sequence ID" value="XM_012748154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F756"/>
    <dbReference type="Ensembl" id="ENSMICT00000027506.2">
        <property type="protein sequence ID" value="ENSMICP00000019956.1"/>
        <property type="gene ID" value="ENSMICG00000035122.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105862111"/>
    <dbReference type="KEGG" id="mmur:105862111"/>
    <dbReference type="CTD" id="7432"/>
    <dbReference type="GeneTree" id="ENSGT00950000183154"/>
    <dbReference type="OrthoDB" id="8795594at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051428">
        <property type="term" value="F:peptide hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031891">
        <property type="term" value="F:type 1 vasoactive intestinal polypeptide receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031892">
        <property type="term" value="F:type 2 vasoactive intestinal polypeptide receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048242">
        <property type="term" value="P:epinephrine secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.590">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000532">
        <property type="entry name" value="Glucagon_GIP_secretin_VIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046963">
        <property type="entry name" value="VIP/GHRH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11213">
        <property type="entry name" value="GLUCAGON-FAMILY NEUROPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11213:SF5">
        <property type="entry name" value="VIP PEPTIDES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00123">
        <property type="entry name" value="Hormone_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00070">
        <property type="entry name" value="GLUCA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00260">
        <property type="entry name" value="GLUCAGON"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0027">Amidation</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133525" evidence="7">
        <location>
            <begin position="26"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="8">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Glucagon / GIP / secretin / VIP family" evidence="8">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="170" mass="19033" checksum="7E24EF6FF9999015" modified="2022-01-19" version="1">METRSKPQLLALLTLFSVLFSQTLAWPLFGAPSALRLGDRMPFEGADEPDQDSLKADTDILQNALAENDTPYYDVSRYARHADGVFTSDFSRLLGQLSAKKYLESLIGKRVSSGISEDPAPIKRHSDAVFTDNYTRLRKQMAVKKYLNSILNGKRSSEGESPDFPEELEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F9V4</accession>
    <name>A0A8B7F9V4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-type lectin domain family 3 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLEC3A</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024196">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604783.1">
        <property type="nucleotide sequence ID" value="XM_012749329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F9V4"/>
    <dbReference type="Ensembl" id="ENSMICT00000060808.1">
        <property type="protein sequence ID" value="ENSMICP00000047998.1"/>
        <property type="gene ID" value="ENSMICG00000047455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105862795"/>
    <dbReference type="KEGG" id="mmur:105862795"/>
    <dbReference type="CTD" id="10143"/>
    <dbReference type="GeneTree" id="ENSGT00950000183186"/>
    <dbReference type="OMA" id="RYICEFL"/>
    <dbReference type="OrthoDB" id="10032136at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001503">
        <property type="term" value="P:ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03596">
        <property type="entry name" value="CLECT_tetranectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000010">
        <property type="entry name" value="C-type lectin domain family 3 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051663">
        <property type="entry name" value="CLec_Tetranectin-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799:SF2">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 3 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22799">
        <property type="entry name" value="TETRANECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133554" evidence="3">
        <location>
            <begin position="23"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="4">
        <location>
            <begin position="74"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="197" mass="22119" checksum="5DF2F61397963032" modified="2022-01-19" version="1">MAKNGLIICFLVITLLLDQTTSLPSKLKARKHSKRRVKEKDGDLKTQVEKLWREVNALKEMQALQTVCLRGTKVHKKCYLASDALKHFHEANEDCISKGGTLVIPRNSDEINALRDYGKSSLPGVNDFWLGINDMVTEGKFVDVNGVAVSFLNWDRAQPNGGKRENCVLFSQSAQGKWSDEACRSSKKYICEFTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FI90</accession>
    <name>A0A8B7FI90_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Amphoterin-induced protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">AMIGO-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">AMIGO2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Binds itself as well as AMIGO1 and AMIGO3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the immunoglobulin superfamily. AMIGO family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608214.1">
        <property type="nucleotide sequence ID" value="XM_012752760.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FI90"/>
    <dbReference type="Ensembl" id="ENSMICT00000016819.3">
        <property type="protein sequence ID" value="ENSMICP00000015327.2"/>
        <property type="gene ID" value="ENSMICG00000016826.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864713"/>
    <dbReference type="KEGG" id="mmur:105864713"/>
    <dbReference type="CTD" id="347902"/>
    <dbReference type="GeneTree" id="ENSGT00950000183146"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001047">
        <property type="entry name" value="amphoterin-induced protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000170">
        <property type="entry name" value="amphoterin-induced protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031283">
        <property type="entry name" value="AMIGO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24368">
        <property type="entry name" value="AMPHOTERIN-INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24368:SF209">
        <property type="entry name" value="AMPHOTERIN-INDUCED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133614" description="Amphoterin-induced protein 2" evidence="21">
        <location>
            <begin position="39"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="22">
        <location>
            <begin position="302"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015327.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="521" mass="57938" checksum="0A97F8734ADB7623" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FL11</accession>
    <name>A0A8B7FL11_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vestigial like family member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">VGLL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vestigial family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609310.1">
        <property type="nucleotide sequence ID" value="XM_012753856.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FL11"/>
    <dbReference type="Ensembl" id="ENSMICT00000033650.2">
        <property type="protein sequence ID" value="ENSMICP00000020092.1"/>
        <property type="gene ID" value="ENSMICG00000007779.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865359"/>
    <dbReference type="CTD" id="245806"/>
    <dbReference type="GeneTree" id="ENSGT00530000063353"/>
    <dbReference type="OrthoDB" id="10069705at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011520">
        <property type="entry name" value="Vg_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15950:SF17">
        <property type="entry name" value="TRANSCRIPTION COFACTOR VESTIGIAL-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07545">
        <property type="entry name" value="Vg_Tdu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="322" mass="33954" checksum="B0F14484FB2D93FF" modified="2022-01-19" version="1">MSCLDVMYQVYGPPQPYFAAAYTPYHQKLAYYSKMQEAQECNASPSSSGSGSSSFSSQTPASIKEEEGSPEKECPPEAEYINSRCVLFTYFQGDISSVVDEHFSRALSQPSSYSPSCTSSKAPRNSGPWQDGSFPMSQRSFPASFWNSAYQAPVPAPLGSPLAAAHSELPFAAADPYSPAALHSHLHQGTTEPWHHAHPHHAHPHHAHPHHPYALGSALGAQAAAYPRPAGVHEVYAPHFDPRYGPLLMPTASGRPARLAPGPAPAPGSPPCELSAKSEPAGAAWAAPGGPFASPAGDVAQGLGLSVDSARRYSLCGASLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FTY5</accession>
    <name>A0A8B7FTY5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear receptor subfamily 0 group B member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear receptor DAX-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NR0B1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Nuclear receptor that lacks a DNA-binding domain and acts as a corepressor that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Interacts with NR5A1, NR5A2, NR0B2 and with COPS2. Interacts with ESRRB; represses ESRRB activity at the GATA6 promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nuclear hormone receptor family. NR0 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612325.1">
        <property type="nucleotide sequence ID" value="XM_012756871.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FTY5"/>
    <dbReference type="Ensembl" id="ENSMICT00000066734.1">
        <property type="protein sequence ID" value="ENSMICP00000043441.1"/>
        <property type="gene ID" value="ENSMICG00000047871.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105867095"/>
    <dbReference type="KEGG" id="mmur:105867095"/>
    <dbReference type="CTD" id="190"/>
    <dbReference type="GeneTree" id="ENSGT00390000015719"/>
    <dbReference type="OrthoDB" id="9926883at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Retinoid X Receptor"/>
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        <property type="entry name" value="NHR-like_dom_sf"/>
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        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
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        <property type="entry name" value="Nuclear_receptor_repeat"/>
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        <property type="entry name" value="STRDHORMONER"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NR LBD" evidence="15">
        <location>
            <begin position="206"/>
            <end position="467"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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    <sequence length="468" mass="51709" checksum="1F5CB5B033C284D5" modified="2022-01-19" version="1">MAGEDHQWQGSILYNMLMSAKQTRTAAEAPEARRGAPCWGCSCGAEPAVGREGLFSGRAMTLLYRCCFCGEDHPRQGSILFNMLTSAKQMQRAPEARPGAPCWGCSCGAEPVVGREGVPGGRAVALTYRCCFCGEDHPRQGSILYSLLTSAKQAHVAPEAPEARPAGEWWERSNCSQRLRGREGLLGGRAMSLLYRCRLCGDDHSPQGSILYNMPTRANQTRAAPEAQSGAPWWDTSCGAQRPVALKSPQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRSCWAPLLMLELAQDRMQFETVETAEPSMLQRILTTRRRETASDEPLSLATLQPHLASPRETGRLPSAAEVQAIKGFLAKCWSLNISTKEYAYLKGTVLFNPDLPGLQCVKYIQGLQWGTQQILNEHVRMTHRGHQARFAELNSALFLLRFINANVIAELFFRPIIGTVSMDDMMLEMLCAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FYL0</accession>
    <name>A0A8B7FYL0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">G protein-coupled receptor 146</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GPR146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021029">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614622.1">
        <property type="nucleotide sequence ID" value="XM_012759168.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614623.1">
        <property type="nucleotide sequence ID" value="XM_012759169.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614624.1">
        <property type="nucleotide sequence ID" value="XM_012759170.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FYL0"/>
    <dbReference type="Ensembl" id="ENSMICT00000002096.3">
        <property type="protein sequence ID" value="ENSMICP00000001917.1"/>
        <property type="gene ID" value="ENSMICG00000002101.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868378"/>
    <dbReference type="KEGG" id="mmur:105868378"/>
    <dbReference type="CTD" id="115330"/>
    <dbReference type="GeneTree" id="ENSGT01030000234518"/>
    <dbReference type="OMA" id="YICSHVA"/>
    <dbReference type="OrthoDB" id="8660770at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045542">
        <property type="term" value="P:positive regulation of cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035456">
        <property type="term" value="P:response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14990">
        <property type="entry name" value="7tmA_GPR146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047143">
        <property type="entry name" value="GPER1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037487">
        <property type="entry name" value="GPR146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24226:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 146-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24226">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 182 AND ESTROGEN RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="44"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="36074" checksum="328F07036DC85259" modified="2022-01-19" version="1">MWGCGWFNGTGRSEEPPACQDLQLGLSVLSLLCLAAGVPIGLCYNGLLVLANLHSKNSMTMPDVYFVNMAVAGLVLNALAPVCLLGTPGSAWAPWSVSSEAHIALLIPFNVSSLVATYSTTLLSLDHYIERALPRTHMASVHNTRHVCGFIWGGALLTSFSSLLFYICSRVSSRVLECAKMQSAEAADAILVLIGYVVPAPAAIYGLVLISRIQKADTPLDQDTGRLDPSAHRLLVATVCTQFGLWTPHYLTLLGHTVLVSRGKPVDARYTGMVYLAKDLSKVLAFSSSFVMPLLYRHMNKSFPSKLGRLMKKMRCGRRHCAPDPAGLQQVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G3C8</accession>
    <name>A0A8B7G3C8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetratricopeptide repeat protein 21B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Intraflagellar transport 139 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TTC21B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Essential for retrograde trafficking of IFT-1, IFT-B and GPCRs. Negatively modulates the SHH signal transduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with WDR35 and TTC21B. Interacts with TTC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TTC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000044005.2">
        <property type="protein sequence ID" value="ENSMICP00000024145.2"/>
        <property type="gene ID" value="ENSMICG00000015487.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068173.1">
        <property type="protein sequence ID" value="ENSMICP00000048302.1"/>
        <property type="gene ID" value="ENSMICG00000015487.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105869409"/>
    <dbReference type="GeneTree" id="ENSGT00390000005979"/>
    <dbReference type="OrthoDB" id="10259630at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030991">
        <property type="term" value="C:intraciliary transport particle A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060020">
        <property type="term" value="P:Bergmann glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021702">
        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021798">
        <property type="term" value="P:forebrain dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035721">
        <property type="term" value="P:intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903999">
        <property type="term" value="P:negative regulation of eating behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097499">
        <property type="term" value="P:protein localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905799">
        <property type="term" value="P:regulation of intraciliary retrograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000197">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000219">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000245">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000493">
        <property type="entry name" value="Tetratricopeptide repeat domain 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056832">
        <property type="entry name" value="ARM_TT21_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056836">
        <property type="entry name" value="ARM_TT21_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056835">
        <property type="entry name" value="ARM_TT21_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056834">
        <property type="entry name" value="ARM_TT21_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056833">
        <property type="entry name" value="ARM_TT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040364">
        <property type="entry name" value="TTC21A/TTC21B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699">
        <property type="entry name" value="STI2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14699:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 21B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25058">
        <property type="entry name" value="ARM_TT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25060">
        <property type="entry name" value="ARM_TT21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25068">
        <property type="entry name" value="ARM_TT21_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25064">
        <property type="entry name" value="ARM_TT21_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25063">
        <property type="entry name" value="ARM_TT21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25062">
        <property type="entry name" value="ARM_TT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B N-terminal ARM repeat" evidence="15">
        <location>
            <begin position="13"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B second ARM" evidence="14">
        <location>
            <begin position="272"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="725"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fourth ARM" evidence="18">
        <location>
            <begin position="761"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B fifth ARM repeats" evidence="17">
        <location>
            <begin position="955"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="13">
        <location>
            <begin position="955"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat protein 21A/21B C-terminal ARM" evidence="16">
        <location>
            <begin position="1106"/>
            <end position="1314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00084066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF25063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF25068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024145.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1319" mass="151416" checksum="D46D0E80EDE50B83" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G6C1</accession>
    <name>A0A8B7G6C1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">HIG1 hypoxia inducible domain family member 1C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HIGD1C</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617775.1">
        <property type="nucleotide sequence ID" value="XM_012762321.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617786.1">
        <property type="nucleotide sequence ID" value="XM_012762332.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617793.1">
        <property type="nucleotide sequence ID" value="XM_012762339.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G6C1"/>
    <dbReference type="Ensembl" id="ENSMICT00000060893.1">
        <property type="protein sequence ID" value="ENSMICP00000043040.1"/>
        <property type="gene ID" value="ENSMICG00000044696.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870041"/>
    <dbReference type="KEGG" id="mmur:105870041"/>
    <dbReference type="CTD" id="613227"/>
    <dbReference type="GeneTree" id="ENSGT00940000162804"/>
    <dbReference type="OrthoDB" id="10003563at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF10">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="97" mass="11138" checksum="93D38D502047A615" modified="2022-01-19" version="1">MSSDNQWSADEDEGQLSRLIRKSRDSPFVPVGIAGFVTVVSYGLYKLKYRRDQKMSIHFIHLRVAAQGFVVGAVTLGVLYSMYKDYIRPRFFNVSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GD10</accession>
    <name>A0A8B7GD10_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcyclin-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CACYBP</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620535.1">
        <property type="nucleotide sequence ID" value="XM_012765081.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GD10"/>
    <dbReference type="Ensembl" id="ENSMICT00000041500.2">
        <property type="protein sequence ID" value="ENSMICP00000021588.1"/>
        <property type="gene ID" value="ENSMICG00000004856.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871644"/>
    <dbReference type="KEGG" id="mmur:105871644"/>
    <dbReference type="CTD" id="27101"/>
    <dbReference type="GeneTree" id="ENSGT00390000016470"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000006">
        <property type="entry name" value="calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000006">
        <property type="entry name" value="calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037201">
        <property type="entry name" value="CacyBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015120">
        <property type="entry name" value="Siah-Interact_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09032">
        <property type="entry name" value="Siah-Interact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140106">
        <property type="entry name" value="Calcyclin-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CS" evidence="12">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="11">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="230" mass="26450" checksum="9BE618E7F6B82BAF" modified="2022-01-19" version="1">MASALEELQKDLEEVKMLLEKASRKRVRDALTAEKTKIETEIKNKMQQKSQRKAEHLDNEKPAAVVAPITTGYTVKISNYGWDQSDKFVKIYITLTGVHQVPTENVQVHFTERSFDLLVKNLNGKSYSMIVNNLLKPISVEGSSKKVKTDTVLILCRKKAENTRWDYLTQVEKECKEKEKPSYDTETDPSEGLMNVLKKIYEDGDDDMKRTINKAWVESREKQAKGDTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GIL6</accession>
    <name>A0A8B7GIL6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box I1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FOXI1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622715.1">
        <property type="nucleotide sequence ID" value="XM_012767261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GIL6"/>
    <dbReference type="Ensembl" id="ENSMICT00000063460.1">
        <property type="protein sequence ID" value="ENSMICP00000047670.1"/>
        <property type="gene ID" value="ENSMICG00000041455.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872877"/>
    <dbReference type="KEGG" id="mmur:105872877"/>
    <dbReference type="CTD" id="2299"/>
    <dbReference type="GeneTree" id="ENSGT00940000161316"/>
    <dbReference type="OrthoDB" id="5402974at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20053">
        <property type="entry name" value="FH_FOXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF180">
        <property type="entry name" value="FORKHEAD BOX PROTEIN I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="379" mass="40428" checksum="EFD32E248364A9B7" modified="2022-01-19" version="1">MSSFDLPVPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRAPSFEGGSEYGATPNPYLWLNGPTATPPPYLPGAGAGPFLPQAYGVQRPLLPAVPGLGGGELGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSSGSLASEKAENSLLAGSPEGSEPQDMLDGGSPGTASPSEKRSPPPPTGAPCLSSFLSSMTAYAGGASPMGRPATTPGGLSPEPDDKMGQNSLSFNSFTPLTNLSSHGAGGDWANPVPANALGYGGSVLNQFGPHFYNGISTNGVLYPREGTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKN4</accession>
    <name>A0A8B7GKN4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="4">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GSTK1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03015146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623544.1">
        <property type="nucleotide sequence ID" value="XM_012768090.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKN4"/>
    <dbReference type="Ensembl" id="ENSMICT00000043976.2">
        <property type="protein sequence ID" value="ENSMICP00000035326.1"/>
        <property type="gene ID" value="ENSMICG00000015493.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873288"/>
    <dbReference type="KEGG" id="mmur:105873288"/>
    <dbReference type="CTD" id="373156"/>
    <dbReference type="GeneTree" id="ENSGT00440000033697"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03021">
        <property type="entry name" value="DsbA_GSTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000096">
        <property type="entry name" value="Glutathione S-transferase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044088">
        <property type="entry name" value="GSTK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF2">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="6">
        <location>
            <begin position="7"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="226" mass="25554" checksum="2114B21859FADA06" modified="2022-01-19" version="1">MGPLPRTLELFYDVLSPYSWLGFEVLCRYQNIWNIRLQLRPSLIAGIMKDSGNKPPALLPRKAQYLRGDIKLLRQQFQVPIQFPGDFLSVILEKGSLSAMRFLTALSLEHPEMLEKVSRELWMRVWSRDEDITEPQSILAAAEKAGMTAEQARGILEKISTPKVKNQLRETTEAACKYGAFGLPITVAHVDGQAHMLFGSDRMELLAYLLGEKWMGPVPPAMNARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GNF0</accession>
    <name>A0A8B7GNF0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">STT3B</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Component of the oligosaccharyltransferase (OST) complex. There are 2 OST complexes, OST-A and OST-B, which contain STT3A or STT3B as catalytic subunit, respectively. OST-A and OST-B contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, and OST-B contains either MAGT1 or TUSC3 as specific accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03000225">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624622.1">
        <property type="nucleotide sequence ID" value="XM_012769168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GNF0"/>
    <dbReference type="Ensembl" id="ENSMICT00000072956.1">
        <property type="protein sequence ID" value="ENSMICP00000051446.1"/>
        <property type="gene ID" value="ENSMICG00000049465.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873872"/>
    <dbReference type="KEGG" id="mmur:105873872"/>
    <dbReference type="CTD" id="201595"/>
    <dbReference type="GeneTree" id="ENSGT00940000155488"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160227">
        <property type="term" value="C:oligosaccharyltransferase complex B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="72"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="601"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00065008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00070525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="826" mass="93701" checksum="E4CAF0041BB612E4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H0T3</accession>
    <name>A0A8B7H0T3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="12">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HECTD1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with IGSF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03004312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004313">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628893.1">
        <property type="nucleotide sequence ID" value="XM_012773439.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000033520.2">
        <property type="protein sequence ID" value="ENSMICP00000039881.2"/>
        <property type="gene ID" value="ENSMICG00000034057.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875964"/>
    <dbReference type="KEGG" id="mmur:105875964"/>
    <dbReference type="CTD" id="25831"/>
    <dbReference type="GeneTree" id="ENSGT00940000156572"/>
    <dbReference type="OrthoDB" id="412600at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21062">
        <property type="entry name" value="BTHB_HectD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000051">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000085">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000014">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000018">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000021">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000033">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.80:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECTD1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000007">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041200">
        <property type="entry name" value="FKBP3_BTHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010606">
        <property type="entry name" value="Mib_Herc2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037252">
        <property type="entry name" value="Mib_Herc2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18410">
        <property type="entry name" value="BTHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06701">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF159034">
        <property type="entry name" value="Mib/herc2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51416">
        <property type="entry name" value="MIB_HERC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="395"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="426"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="MIB/HERC2" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="2151"/>
            <end position="2610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="269"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="489"/>
            <end position="513"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="627"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="707"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1343"/>
            <end position="1406"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1433"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1496"/>
            <end position="1515"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1592"/>
            <end position="1611"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1674"/>
            <end position="1757"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1777"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2297"/>
            <end position="2318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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    </feature>
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        <location>
            <begin position="707"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="718"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1348"/>
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        <location>
            <begin position="1373"/>
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        <location>
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            <position position="2579"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00065700"/>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369009"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51416"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039881.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2610" mass="289297" checksum="87AC493299A33076" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H4R1</accession>
    <name>A0A8B7H4R1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Beta-1,4-galactosyltransferase</fullName>
            <shortName evidence="17">Beta-1,4-GalTase</shortName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">B4GALT2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1-&gt;4)-N-acetyl-D-glucosamine + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17745"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:60152"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:506227"/>
            <dbReference type="EC" id="2.4.1.90"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:17746"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 7 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03001561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631386.1">
        <property type="nucleotide sequence ID" value="XM_012775932.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631387.1">
        <property type="nucleotide sequence ID" value="XM_012775933.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H4R1"/>
    <dbReference type="Ensembl" id="ENSMICT00000036140.2">
        <property type="protein sequence ID" value="ENSMICP00000027545.1"/>
        <property type="gene ID" value="ENSMICG00000029762.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105877433"/>
    <dbReference type="KEGG" id="mmur:105877433"/>
    <dbReference type="CTD" id="8704"/>
    <dbReference type="GeneTree" id="ENSGT00940000159367"/>
    <dbReference type="OrthoDB" id="10016069at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003945">
        <property type="term" value="F:N-acetyllactosamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00899">
        <property type="entry name" value="b4GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000028">
        <property type="entry name" value="beta-1,4-galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003859">
        <property type="entry name" value="Galactosyl_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027995">
        <property type="entry name" value="Galactosyl_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19300:SF32">
        <property type="entry name" value="BETA-1,4-GALACTOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13733">
        <property type="entry name" value="Glyco_transf_7N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02050">
        <property type="entry name" value="B14GALTRFASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14 17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase N-terminal" evidence="20">
        <location>
            <begin position="94"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="19">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="48"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="369" mass="41843" checksum="8606D14FE8AFAB02" modified="2022-01-19" version="1">MSRLLGGTLERVCKAVLLLCLLHFLVAVILYFDVYAQHLAFFTRSSARGPPRALHPAASSNSNCSRPNATAPSSGLPEVPSARPGPTAPVLPPCPDSPPGLVGRLLIEFTSPMPLERVQRENPGVLLGGRYTPPDCTPAQTVAVIIPFRHREHHLRYWLHYLHPILRRQRLRYGVYVINQHGEDTFNRAKLLNVGFLEALKEDATYDCFIFSDVDLVPMDDRNLYRCGDQPRHFATAMDKFGFRLPYAGYFGGVSGLSKAQFLRINGFPNEYWGWGGEDDDIFNRISLTGMKISRPDIRIGRYRMIKHDRDKHNEPNPQRFTRIQNTKQTMKRDGIGSVQYQVLEVSRQPLFTNITVDIGRPPPWHSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HCI7</accession>
    <name>A0A8B7HCI7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 20">Splicing factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SF1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 20">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633437.1">
        <property type="nucleotide sequence ID" value="XM_012777983.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HCI7"/>
    <dbReference type="Ensembl" id="ENSMICT00000050903.2">
        <property type="protein sequence ID" value="ENSMICP00000030188.2"/>
        <property type="gene ID" value="ENSMICG00000001202.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878489"/>
    <dbReference type="KEGG" id="mmur:105878489"/>
    <dbReference type="CTD" id="7536"/>
    <dbReference type="GeneTree" id="ENSGT00940000157258"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22382">
        <property type="entry name" value="KH-I_SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000016">
        <property type="entry name" value="Putative splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
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    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
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    <sequence length="638" mass="68259" checksum="C4BF17AE36992E84" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HEB5</accession>
    <name>A0A8B7HEB5_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Potassium channel tetramerization domain containing 2</fullName>
        </submittedName>
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        <name evidence="3" type="primary">KCTD2</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000029951.2"/>
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        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
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        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
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        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="72"/>
            <end position="175"/>
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    </feature>
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    </feature>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="263" mass="28517" checksum="C550476C40FA482C" modified="2022-01-19" version="1">MAELQLDPAMAGLGGGGGSGVGDGGGPGRGPPSPRPAGPMPRGHGRPSAAVAQPLDPGPGPPERAGGGGAARWVRLNVGGTYFVTTRQTLGREPKSFLCRLCCQEDPELDSDKDETGAYLIDRDPTYFGPILNYLRHGKLIITKELAEEGVLEEAEFYNIASLVRLVKERIRDNENRTSQGPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLISIGSSYNYGNEDQAEFLCVVSRELNNSTNGIVIEPSEKAKILQERGSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HEL1</accession>
    <name>A0A8B7HEL1_MICMU</name>
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        <recommendedName>
            <fullName evidence="6">D-aminoacyl-tRNA deacylase</fullName>
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        </recommendedName>
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        <name evidence="8" type="primary">DTD1</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
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        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer. Interacts with CDC45 and TOPBP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03021522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635451.1">
        <property type="nucleotide sequence ID" value="XM_012779997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HEL1"/>
    <dbReference type="Ensembl" id="ENSMICT00000010762.3">
        <property type="protein sequence ID" value="ENSMICP00000009808.3"/>
        <property type="gene ID" value="ENSMICG00000010771.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879622"/>
    <dbReference type="KEGG" id="mmur:105879622"/>
    <dbReference type="CTD" id="92675"/>
    <dbReference type="GeneTree" id="ENSGT00940000153431"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="181"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00054206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00062485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009808.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="209" mass="23433" checksum="1E1F7B40B25FE080" modified="2022-01-19" version="1">MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKILNLRVFEDESGKHWSKSVMDKQYEVLCVSQFTLQCVLKGHKPDFHLAMPTEQAEGFYNSFLEQLRKMYRPELIKDGKFGAYMQVHIQNDGPVTIELESPAPGAATSDPKQLSKLEKQQQRKEKTRAKGPSESSKERNTPRKEDRSASSGAEGDVSSEREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HK67</accession>
    <name>A0A8B7HK67_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inner nuclear membrane protein Man1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">LEM domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LEMD3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with SMAD1, SMAD2, SMAD3 and SMAD5. Binds to both phosphorylated and unphosphorylated R-SMADS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637851.1">
        <property type="nucleotide sequence ID" value="XM_012782397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HK67"/>
    <dbReference type="Ensembl" id="ENSMICT00000012101.3">
        <property type="protein sequence ID" value="ENSMICP00000011014.2"/>
        <property type="gene ID" value="ENSMICG00000012102.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880973"/>
    <dbReference type="KEGG" id="mmur:105880973"/>
    <dbReference type="CTD" id="23592"/>
    <dbReference type="GeneTree" id="ENSGT00940000157643"/>
    <dbReference type="OrthoDB" id="118234at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032926">
        <property type="term" value="P:negative regulation of activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12942">
        <property type="entry name" value="LEM_Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12286">
        <property type="entry name" value="RRM_Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1180:FF:000001">
        <property type="entry name" value="inner nuclear membrane protein Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000176">
        <property type="entry name" value="Inner nuclear membrane protein Man1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.720.40:FF:000001">
        <property type="entry name" value="LEM domain containing 2, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052277">
        <property type="entry name" value="INM_ESCRT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011015">
        <property type="entry name" value="LEM/LEM-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003887">
        <property type="entry name" value="LEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034394">
        <property type="entry name" value="Man1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428:SF10">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13428">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN MAN1 LEM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03020">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00540">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63451">
        <property type="entry name" value="LEM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50954">
        <property type="entry name" value="LEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="LEM" evidence="14">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011014.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="912" mass="99932" checksum="1C2BCD9F54D8DD4B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HK79</accession>
    <name>A0A8B7HK79_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transforming acidic coiled-coil containing protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TACC2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019509">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019510">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019511">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636731.1">
        <property type="nucleotide sequence ID" value="XM_012781277.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HK79"/>
    <dbReference type="Ensembl" id="ENSMICT00000009838.3">
        <property type="protein sequence ID" value="ENSMICP00000008959.3"/>
        <property type="gene ID" value="ENSMICG00000009830.3"/>
    </dbReference>
    <dbReference type="CTD" id="10579"/>
    <dbReference type="GeneTree" id="ENSGT00940000157052"/>
    <dbReference type="OrthoDB" id="10255048at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF11">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="891"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="900"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008959.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1097" mass="118926" checksum="B2D8D471DFB8715A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HL34</accession>
    <name>A0A8B7HL34_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Clarin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CLRN1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May have a role in the excitatory ribbon synapse junctions between hair cells and cochlear ganglion cells and presumably also in analogous synapses within the retina.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the clarin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000592">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638261.1">
        <property type="nucleotide sequence ID" value="XM_012782807.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HL34"/>
    <dbReference type="Ensembl" id="ENSMICT00000073415.1">
        <property type="protein sequence ID" value="ENSMICP00000050943.1"/>
        <property type="gene ID" value="ENSMICG00000049572.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105881231"/>
    <dbReference type="KEGG" id="mmur:105881231"/>
    <dbReference type="CTD" id="7401"/>
    <dbReference type="GeneTree" id="ENSGT00850000132319"/>
    <dbReference type="OrthoDB" id="10012538at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030140">
        <property type="term" value="C:trans-Golgi network transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048870">
        <property type="term" value="P:cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010592">
        <property type="term" value="P:positive regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000045">
        <property type="entry name" value="Clarin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026748">
        <property type="entry name" value="Clarin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548">
        <property type="entry name" value="CLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31548:SF4">
        <property type="entry name" value="CLARIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25807">
        <property type="entry name" value="Clarin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1009">Hearing</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0844">Vision</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="232" mass="25708" checksum="39758D7287A3FF86" modified="2022-01-19" version="1">MPNQQKKIIFCTAGVLSFACALGVVTALGTPLWIKATILCKTGALLVNASGQELDKFMGEMQYGLFHGEGVRQCGLGARPFRFSFFPDLLKAIPVSIHVNVILFSTILIVLTMVGTAFFMYNAFGKPFETLHGPLGLYLLSFISGSCGCLVMILFASEVKIHHLSEKIANYKEGTYAYKTQSEKYTTSFWVIFICFFVHFLNGLLIRLAGFQFPFAKSKETETTNVAADLMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRE9</accession>
    <name>A0A8B7HRE9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Myotubularin related protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">MTMR7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023758">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640460.1">
        <property type="nucleotide sequence ID" value="XM_012785006.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRE9"/>
    <dbReference type="Ensembl" id="ENSMICT00000002876.3">
        <property type="protein sequence ID" value="ENSMICP00000002619.2"/>
        <property type="gene ID" value="ENSMICG00000002877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882531"/>
    <dbReference type="KEGG" id="mmur:105882531"/>
    <dbReference type="CTD" id="9108"/>
    <dbReference type="GeneTree" id="ENSGT00940000155777"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052629">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13344">
        <property type="entry name" value="PH-GRAM_MTMR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14583">
        <property type="entry name" value="PTP-MTMR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000135">
        <property type="entry name" value="Myotubularin related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036003">
        <property type="entry name" value="MTMR7_PH-GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030572">
        <property type="entry name" value="MTMR7_PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048994">
        <property type="entry name" value="PH-GRAM_MTMR6-9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF35">
        <property type="entry name" value="MYOTUBULARIN-RELATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21098">
        <property type="entry name" value="PH-GRAM_MTMR6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="12">
        <location>
            <begin position="126"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="11">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="550"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="7">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="275"/>
            <end position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="338"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002619.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="660" mass="75842" checksum="2B15D29A81B1D01E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HT82</accession>
    <name>A0A8B7HT82_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Glycine receptor alpha 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="30">Glycine receptor subunit alpha-2 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28 30" type="primary">GLRA2</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Postsynaptic cell membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035916">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640241.1">
        <property type="nucleotide sequence ID" value="XM_012784787.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640242.1">
        <property type="nucleotide sequence ID" value="XM_012784788.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HT82"/>
    <dbReference type="Ensembl" id="ENSMICT00000015571.3">
        <property type="protein sequence ID" value="ENSMICP00000014191.2"/>
        <property type="gene ID" value="ENSMICG00000015578.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882422"/>
    <dbReference type="KEGG" id="mmur:105882422"/>
    <dbReference type="CTD" id="2742"/>
    <dbReference type="GeneTree" id="ENSGT00940000158730"/>
    <dbReference type="OrthoDB" id="407674at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098690">
        <property type="term" value="C:glycinergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016934">
        <property type="term" value="F:extracellularly glycine-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022852">
        <property type="term" value="F:glycine-gated chloride ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071361">
        <property type="term" value="P:cellular response to ethanol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071294">
        <property type="term" value="P:cellular response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050804">
        <property type="term" value="P:modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19009">
        <property type="entry name" value="LGIC_ECD_GlyR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19060">
        <property type="entry name" value="LGIC_TM_GlyR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000002">
        <property type="entry name" value="Glycine receptor alpha 1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000003">
        <property type="entry name" value="Glycine receptor alpha 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008127">
        <property type="entry name" value="Glycine_rcpt_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008129">
        <property type="entry name" value="Glycine_rcpt_A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01673">
        <property type="entry name" value="GLYRALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01675">
        <property type="entry name" value="GLYRALPHA2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0868">Chloride</keyword>
    <keyword evidence="12" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 24" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 24" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="9 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="11 30" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 24" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 24" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519624" evidence="24">
        <location>
            <begin position="20"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="26">
        <location>
            <begin position="49"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="27">
        <location>
            <begin position="261"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="236"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>strychnine</name>
            <dbReference type="ChEBI" id="CHEBI:90700"/>
            <note>antagonist</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for obstruction of the ion pore in the closed conformation" evidence="21">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR608127-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR608127-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR608127-53"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014191.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_012640242.1"/>
        </source>
    </evidence>
    <sequence length="452" mass="52000" checksum="D6C9A5A7D991387E" modified="2022-01-19" version="1">MNRQLVKILTALFAFFVETNHFRTAFCKDHDSRSGKQPSQTPSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HT89</accession>
    <name>A0A8B7HT89_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein sprouty homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SPRY2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Forms heterodimers with SPRY1. Forms a tripartite complex containing GAB1, METTL13 and SPRY2. Within the complex interacts with METTL13. Interacts with RAF1. Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction disrupts SPRY2 interaction with GRB2, potentially via disruption of SPRY2 serine dephosphorylation. Interacts with PPP2R1A/PP2A-A and PPP2CA/PP2A-C; the interaction with PPP2CA/PP2A-C is inhibited by interaction with TESK1, possibly by vesicular sequestration of SPRY2. Inhibition of the interaction with the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme results in loss of PP2A-mediated dephosphorylation, resulting in the loss of SPRY2 interaction with GRB2. Interacts with GRB2. Interacts with CBL/C-CBL; the interaction inhibits CBL-mediated ubiquitination of EGFR. Interacts (via C-terminus) with CAV1 (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Ruffle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sprouty family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641222.1">
        <property type="nucleotide sequence ID" value="XM_012785768.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641224.1">
        <property type="nucleotide sequence ID" value="XM_012785770.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HT89"/>
    <dbReference type="Ensembl" id="ENSMICT00000008535.3">
        <property type="protein sequence ID" value="ENSMICP00000007774.3"/>
        <property type="gene ID" value="ENSMICG00000008542.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882981"/>
    <dbReference type="KEGG" id="mmur:105882981"/>
    <dbReference type="CTD" id="10253"/>
    <dbReference type="GeneTree" id="ENSGT00950000183055"/>
    <dbReference type="OMA" id="TQSHCCV"/>
    <dbReference type="OrthoDB" id="10038884at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990752">
        <property type="term" value="C:microtubule end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055105">
        <property type="term" value="F:ubiquitin-protein transferase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060449">
        <property type="term" value="P:bud elongation involved in lung branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035924">
        <property type="term" value="P:cellular response to vascular endothelial growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060437">
        <property type="term" value="P:lung growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031345">
        <property type="term" value="P:negative regulation of cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042059">
        <property type="term" value="P:negative regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902747">
        <property type="term" value="P:negative regulation of lens fiber cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051387">
        <property type="term" value="P:negative regulation of neurotrophin TRK receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900747">
        <property type="term" value="P:negative regulation of vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF8">
        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007774.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="34627" checksum="32975D3DF4D72EFA" modified="2022-01-19" version="1">MEARAQSGNGSQPLVQAPRDSGRQRGEPDLRDTLTQQVHVLSLDQIRAIRNTNEYTEGPTVVPRPGLKPAPRPSTQHKHERLHGLPEHRQPPRLQHSQVHASARAPLSRSISTVSSGSRSSTRTSTSSSSSEQRLLGPSFSAPVGDGIIRVQPKSELKPGELKPLSKEDLGLHAYRCEDCGKCKCKECTYPRPLPSDWICDKQCLCSAQNVIDYGTCVCCVKGLFYHCSNDDEDNCADNPCSCSQSHCCTRWSAMGVMSLFLPCLWCYLPAKGCLKLCQGCYDRVNRPGCRCKNSNTVCCKVPTVPPRNFEKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HV22</accession>
    <name>A0A8B7HV22_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase/reductase 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DHRS7</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641137.1">
        <property type="nucleotide sequence ID" value="XM_012785683.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HV22"/>
    <dbReference type="Ensembl" id="ENSMICT00000012540.3">
        <property type="protein sequence ID" value="ENSMICP00000011421.2"/>
        <property type="gene ID" value="ENSMICG00000012540.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882932"/>
    <dbReference type="KEGG" id="mmur:105882932"/>
    <dbReference type="CTD" id="51635"/>
    <dbReference type="GeneTree" id="ENSGT00940000155226"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05332">
        <property type="entry name" value="11beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF1">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011421.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="341" mass="38546" checksum="D8784921701D9BE4" modified="2022-01-19" version="1">MSWELVLWLLALCAPLLLLVQLLRFLRADGDLALLWAEWQGRRPEWELTDMVVWVTGASSGIGEELAFQLSKLGVSLVLSARRVPELERVKRRCLENGNLKEKDILVLPLDLTDRSSHEAATKTVLQEFGRIDILVNNGGRTQRSLCVDTSMDVYKELIELNYLGTISLTKCVLPHMIERKQGKIVTVNSFMGILSAPLSTGYSASKHALQGFFNGLRTELDNTCPGIIVSNICPGPVQSDIVKNALTEDVTKSSPGSYGDQSYKMATSRCVRLMLITMANDLKEVWIAHQPFLLMPYLWQYMPTWAWWITSKLGKKRIENFQSGMDADSFYFKTWKAKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I705</accession>
    <name>A0A8B7I705_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PAT complex subunit Asterix</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WDR83OS</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein. Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Asterix family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027788">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645953.1">
        <property type="nucleotide sequence ID" value="XM_012790499.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I705"/>
    <dbReference type="SMR" id="A0A8B7I705"/>
    <dbReference type="Ensembl" id="ENSMICT00000039239.2">
        <property type="protein sequence ID" value="ENSMICP00000031161.2"/>
        <property type="gene ID" value="ENSMICG00000041694.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105885525"/>
    <dbReference type="KEGG" id="mmur:105885525"/>
    <dbReference type="CTD" id="51398"/>
    <dbReference type="GeneTree" id="ENSGT00390000002121"/>
    <dbReference type="OMA" id="MFGLMMK"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160064">
        <property type="term" value="C:multi-pass translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101031">
        <property type="term" value="C:protein folding chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160063">
        <property type="term" value="P:multi-pass transmembrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193">
        <property type="entry name" value="CGI-140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13193:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT ASTERIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031161.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="106" mass="12038" checksum="9C2BDDAF92681606" modified="2022-01-19" version="1">MSANNMSDPRRPNKVLRYKPPPSECNPALDDPTPDYMNLLGMIFSMCGLMLKLKWCAWVAVYCSFISFANSRSSEDTKQMMSSFMLSISAVVMSYLQNPQPMTPPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7IAQ3</accession>
    <name>A0A8B7IAQ3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SplA/ryanodine receptor domain and SOCS box containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SPSB1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SPSB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002438">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646913.1">
        <property type="nucleotide sequence ID" value="XM_012791459.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646914.1">
        <property type="nucleotide sequence ID" value="XM_012791460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7IAQ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000040317.2">
        <property type="protein sequence ID" value="ENSMICP00000031479.2"/>
        <property type="gene ID" value="ENSMICG00000030829.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000044798.2">
        <property type="protein sequence ID" value="ENSMICP00000017266.1"/>
        <property type="gene ID" value="ENSMICG00000030829.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000066526.1">
        <property type="protein sequence ID" value="ENSMICP00000040643.1"/>
        <property type="gene ID" value="ENSMICG00000030829.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068744.1">
        <property type="protein sequence ID" value="ENSMICP00000043575.1"/>
        <property type="gene ID" value="ENSMICG00000030829.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105886072"/>
    <dbReference type="KEGG" id="mmur:105886072"/>
    <dbReference type="CTD" id="80176"/>
    <dbReference type="GeneTree" id="ENSGT01030000234629"/>
    <dbReference type="OMA" id="SESYGWD"/>
    <dbReference type="OrthoDB" id="5547302at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12906">
        <property type="entry name" value="SPRY_SOCS1-2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000007">
        <property type="entry name" value="SPRY domain-containing SOCS box protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050672">
        <property type="entry name" value="FBXO45-Fsn/SPSB_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245">
        <property type="entry name" value="SPRY DOMAIN CONTAINING SOCS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12245:SF8">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING SOCS BOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="33"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="6">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031479.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="273" mass="30865" checksum="BAB04BFBFBA9642A" modified="2022-01-19" version="1">MGQKVTGGIKTVDMRDPAYRPLKQELQGLDYCKPTRLDLLLDMPPVPYDVQLLHSWNNDDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGKERLGEIHALPLPASLKAYLLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WNW9</accession>
    <name>A0A8B7WNW9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Family with sequence similarity 171 member A2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FAM171A2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM171 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136570.1">
        <property type="nucleotide sequence ID" value="XM_020280981.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WNW9"/>
    <dbReference type="Ensembl" id="ENSMICT00000034671.2">
        <property type="protein sequence ID" value="ENSMICP00000020792.2"/>
        <property type="gene ID" value="ENSMICG00000029059.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105883551"/>
    <dbReference type="KEGG" id="mmur:105883551"/>
    <dbReference type="CTD" id="284069"/>
    <dbReference type="GeneTree" id="ENSGT00950000183184"/>
    <dbReference type="OrthoDB" id="8762914at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018890">
        <property type="entry name" value="FAM171"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049175">
        <property type="entry name" value="FAM171_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048530">
        <property type="entry name" value="FAM171_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31626:SF3">
        <property type="entry name" value="PROTEIN FAM171A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31626">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20771">
        <property type="entry name" value="FAM171A1-2-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10577">
        <property type="entry name" value="FAM171A1-2-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135486" evidence="10">
        <location>
            <begin position="30"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="FAM171 N-terminal" evidence="11">
        <location>
            <begin position="41"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FAM171 C-terminal" evidence="12">
        <location>
            <begin position="382"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="379"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="417"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="732"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="793"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020792.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="826" mass="87550" checksum="A8DDA031B62A1249" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WZA1</accession>
    <name>A0A8B7WZA1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MyoD family inhibitor domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MDFIC2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDFI family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033463">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033464">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WZA1"/>
    <dbReference type="Ensembl" id="ENSMICT00000042100.2">
        <property type="protein sequence ID" value="ENSMICP00000030440.2"/>
        <property type="gene ID" value="ENSMICG00000032034.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111641"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026134">
        <property type="entry name" value="MDFI/MDFIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15304">
        <property type="entry name" value="MYOD FAMILY INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15304:SF2">
        <property type="entry name" value="MYOD FAMILY INHIBITOR DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15316">
        <property type="entry name" value="MDFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030440.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="189" mass="21434" checksum="549C4B1517679CA9" modified="2022-01-19" version="1">MSETELEKIKVRTAEHFENDKNNISWLKEDTQLTNEKRADEKPINAIVINSVSEFNITDGPAKESPNEKKLSESSTSLSSLEECQTKFSYLQTDTSVHQRDTDEECASLILTCLFCQFWDCLLMLPDTCETVCANLCCPSHPYHHAPDESHSRNDCGCNCDVDCSLFESCHETGECLELAMEISEICYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X7K6</accession>
    <name>A0A8B7X7K6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Epiphycan</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EPYC</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143524.1">
        <property type="nucleotide sequence ID" value="XM_020287935.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X7K6"/>
    <dbReference type="Ensembl" id="ENSMICT00000017312.3">
        <property type="protein sequence ID" value="ENSMICP00000015769.2"/>
        <property type="gene ID" value="ENSMICG00000017312.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865380"/>
    <dbReference type="KEGG" id="mmur:105865380"/>
    <dbReference type="CTD" id="1833"/>
    <dbReference type="GeneTree" id="ENSGT00940000157574"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061975">
        <property type="term" value="P:articular cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000167">
        <property type="entry name" value="epiphycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043547">
        <property type="entry name" value="Mimecan/Epiphycan/Opticin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269:SF3">
        <property type="entry name" value="EPIPHYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46269">
        <property type="entry name" value="EPIPHYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135550" evidence="11">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="12">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015769.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="322" mass="36717" checksum="DB671D882CF93ACB" modified="2022-01-19" version="1">MKTLARFVLGLVILDAAVAAPTLESINYDSETYDATLEDLDNLYNYENIPIDQAEIEIATVMPSGNRELLTPPPQPKEAQEEEGEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINRNDFASLNDLRRIDMTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYLCLPRLPIGSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM45</accession>
    <name>A0A8C5UM45_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transformation/transcription domain associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TRRAP</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000002931.3">
        <property type="protein sequence ID" value="ENSMICP00000002668.3"/>
        <property type="gene ID" value="ENSMICG00000002909.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017961"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080135">
        <property type="term" value="P:regulation of cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="2684"/>
            <end position="3267"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="3492"/>
            <end position="3815"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="3819"/>
            <end position="3851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2535"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2535"/>
            <end position="2546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002668.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="3851" mass="436971" checksum="E8E7B632C0D62580" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UND9</accession>
    <name>A0A8C5UND9_MICMU</name>
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        <submittedName>
            <fullName evidence="9">Keratin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KRT2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UND9"/>
    <dbReference type="Ensembl" id="ENSMICT00000002215.3">
        <property type="protein sequence ID" value="ENSMICP00000002026.3"/>
        <property type="gene ID" value="ENSMICG00000002217.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162573"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032980">
        <property type="term" value="P:keratinocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003334">
        <property type="term" value="P:keratinocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051546">
        <property type="term" value="P:keratinocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045684">
        <property type="term" value="P:positive regulation of epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF14">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="171"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="226"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="382"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="599"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002026.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="678" mass="68233" checksum="1E73855C875F33B6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UR77</accession>
    <name>A0A8C5UR77_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CDK17</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03009267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630783.1">
        <property type="nucleotide sequence ID" value="XM_012775329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UR77"/>
    <dbReference type="Ensembl" id="ENSMICT00000005550.3">
        <property type="protein sequence ID" value="ENSMICP00000005062.2"/>
        <property type="gene ID" value="ENSMICG00000005540.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877097"/>
    <dbReference type="CTD" id="5128"/>
    <dbReference type="GeneTree" id="ENSGT00940000155834"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07872">
        <property type="entry name" value="STKc_PCTAIRE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000061">
        <property type="entry name" value="Putative cyclin-dependent kinase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF128">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="192"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005062.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="523" mass="59554" checksum="DB483D3BE4D08836" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTV2</accession>
    <name>A0A8C5UTV2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DOCK9</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000008157.3">
        <property type="protein sequence ID" value="ENSMICP00000007431.3"/>
        <property type="gene ID" value="ENSMICG00000008131.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155972"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11698">
        <property type="entry name" value="DHR2_DOCK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000016">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000015">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF77">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="185"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="651"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1616"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1252"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007431.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2081" mass="238048" checksum="C9A1D324561ABA7D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UUT2</accession>
    <name>A0A8C5UUT2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Selenoprotein M</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SELENOM</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the selenoprotein M/F family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UUT2"/>
    <dbReference type="Ensembl" id="ENSMICT00000008553.3">
        <property type="protein sequence ID" value="ENSMICP00000007791.3"/>
        <property type="gene ID" value="ENSMICG00000008556.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154284"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035934">
        <property type="term" value="P:corticosterone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042445">
        <property type="term" value="P:hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010269">
        <property type="term" value="P:response to selenium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.50">
        <property type="entry name" value="Sep15/SelM thioredoxin-like domain, active-site redox motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038219">
        <property type="entry name" value="Sep15/SelM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039992">
        <property type="entry name" value="Sep15_SelM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014912">
        <property type="entry name" value="Sep15_SelM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077">
        <property type="entry name" value="SELENOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13077:SF7">
        <property type="entry name" value="SELENOPROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08806">
        <property type="entry name" value="Sep15_SelM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034434200" description="Selenoprotein M" evidence="5">
        <location>
            <begin position="24"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Selenoprotein F/M" evidence="6">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007791.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="144" mass="16041" checksum="F81BA0D525E88D5C" modified="2022-01-19" version="1">MRLLLPPPPPLLLLAALVASATAATTYRPDWNRLQGLARARVETCGGQLNRLKEVKAFVTQDIPFYHNLVMKHLPGADPELVLLGRRFEELERIPLSEMTRDEINALVQELGFYRKAAPDAQVPPEYLWAPAKSAEGASDRADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVK1</accession>
    <name>A0A8C5UVK1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a homohexamer that can probably bind six kinase subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVK1"/>
    <dbReference type="Ensembl" id="ENSMICT00000007936.3">
        <property type="protein sequence ID" value="ENSMICP00000007228.3"/>
        <property type="gene ID" value="ENSMICG00000007943.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182971"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000001">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007228.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="99" mass="12226" checksum="3A5336A27E799680" modified="2022-01-19" version="1">MAHKQIYYLDKYFDKHYEYRHVMLLQELSKQVPKTHLMSEEEWRRLGVQQSLGWVLYMIHEPETHILFQKINKNERDPLPLLINRKNLIGQLIYIYKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWH1</accession>
    <name>A0A8C5UWH1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EBP like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EBPL</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017716">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017717">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017718">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UWH1"/>
    <dbReference type="Ensembl" id="ENSMICT00000006637.3">
        <property type="protein sequence ID" value="ENSMICP00000006062.3"/>
        <property type="gene ID" value="ENSMICG00000006640.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063715"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006062.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="205" mass="22818" checksum="C3A0885AF354142A" modified="2022-01-19" version="1">MGSTWELEAAPAGALLLCAALLAAGCALGLRLGRGRAAADRGALAWLCYDALVHLVLEGPFVYLSVGNIANSDGLIASLWKEYGKADARWLNFDPTIVSVEILTAVLDGFLALFLIYAIVKEKPYRHFLQITLCVCELYGDWMTFCPEWLVGSPNLNTNNWLYCWVYLVFFNGVWVLIPALLLWQSWVELKKIHQKGTSSGKKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UYB4</accession>
    <name>A0A8C5UYB4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arylsulfatase family member H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARSH</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034666">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03034667">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03034668">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03034669">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UYB4"/>
    <dbReference type="Ensembl" id="ENSMICT00000009733.3">
        <property type="protein sequence ID" value="ENSMICP00000008863.3"/>
        <property type="gene ID" value="ENSMICG00000009734.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162925"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.550:FF:000001">
        <property type="entry name" value="Arylsulfatase E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000233">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000174">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.550">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF16">
        <property type="entry name" value="ARYLSULFATASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14707">
        <property type="entry name" value="Sulfatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="7">
        <location>
            <begin position="7"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008863.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="520" mass="58162" checksum="D91CB3084B642462" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UYU2</accession>
    <name>A0A8C5UYU2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Secretogranin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromogranin-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CHGB</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with ITPR1 in the secretory granules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromogranin/secretogranin protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021693">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610687.1">
        <property type="nucleotide sequence ID" value="XM_012755233.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UYU2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011617.3">
        <property type="protein sequence ID" value="ENSMICP00000010569.2"/>
        <property type="gene ID" value="ENSMICG00000011615.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866067"/>
    <dbReference type="KEGG" id="mmur:105866067"/>
    <dbReference type="CTD" id="1114"/>
    <dbReference type="GeneTree" id="ENSGT00940000154206"/>
    <dbReference type="OrthoDB" id="9907623at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001819">
        <property type="entry name" value="Chromogranin_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018054">
        <property type="entry name" value="Chromogranin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001990">
        <property type="entry name" value="Granin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10583">
        <property type="entry name" value="CHROMOGRANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10583:SF4">
        <property type="entry name" value="SECRETOGRANIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01271">
        <property type="entry name" value="Granin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00659">
        <property type="entry name" value="CHROMOGRANIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00422">
        <property type="entry name" value="GRANINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149934" description="Secretogranin-1" evidence="15">
        <location>
            <begin position="21"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="65"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="622"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="208"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="432"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010569.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="676" mass="77581" checksum="2838BF192C36E723" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1S2</accession>
    <name>A0A8C5V1S2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Matrix metallopeptidase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MMP8</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626025.1">
        <property type="nucleotide sequence ID" value="XM_012770571.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1S2"/>
    <dbReference type="Ensembl" id="ENSMICT00000014459.3">
        <property type="protein sequence ID" value="ENSMICP00000013180.2"/>
        <property type="gene ID" value="ENSMICG00000014462.3"/>
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    <sequence length="465" mass="52800" checksum="38E151A7F6578AE9" modified="2022-01-19" version="1">MFCLKTLPLLLLLHMELSKAFPVPSEGRNAKIVQDYLEKFYRLPSNQYRTARKNSASMVVEKLKEMQRFFGLNVTGKPDAETLEVMEKPRCGVPDSSSFMITPGSPKWEHTNVTYRIISHTQQLSVAEVGAAFEKAFKLWSGASPLTFTRISQGEADIKIAFVQRDHGDNSPFDGPNGILAHAFQPGPGIGGDVHFDAEETWTTNFNNYNLFLVAAHEFGHSLGLAHSSDAGALMYPNYAFSEPSTYTLPQDDINGIQAIYGPSNNPIQPTGPSTPMACDPRLTFDAITTLRGEIFFFKDKYFWRRHPQLRSVELNFISLFWPSLPNGIQAAYEDFDKDLVFLFKGNQYWAMSGYDIQQGYPRHISNYGFPSNVQAIDAAVSYGRKTYFFVNDQLWRYDNQRQAMDPGYPQSISSTFPGIQSRVDAVFQQDDFFLFFSGPRYYAFNLSTNRVTRLDKSNKWLNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2H6</accession>
    <name>A0A8C5V2H6_MICMU</name>
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        <recommendedName>
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            <ecNumber evidence="9">4.6.1.1</ecNumber>
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        <alternativeName>
            <fullName evidence="26">Germ cell soluble adenylyl cyclase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Testicular soluble adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ADCY10</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels. Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03003327">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003329">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000011677.3">
        <property type="protein sequence ID" value="ENSMICP00000010627.3"/>
        <property type="gene ID" value="ENSMICG00000011665.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001322"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071890">
        <property type="term" value="F:bicarbonate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000017">
        <property type="entry name" value="Adenylate cyclase type 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000021">
        <property type="entry name" value="Adenylate cyclase type 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001623">
        <property type="entry name" value="Adenylate cyclase type 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305:SF32">
        <property type="entry name" value="ADENYLATE CYCLASE TYPE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16305">
        <property type="entry name" value="TESTICULAR SOLUBLE ADENYLYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="22" id="KW-0966">Cell projection</keyword>
    <keyword evidence="27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="28">
        <location>
            <begin position="42"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="28">
        <location>
            <begin position="341"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="27">
        <location>
            <begin position="1430"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054660"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078060"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010627.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1565" mass="180948" checksum="CFEA040DD1FE5DF4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2Y1</accession>
    <name>A0A8C5V2Y1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FAM20A golgi associated secretory pathway pseudokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FAM20A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2Y1"/>
    <dbReference type="Ensembl" id="ENSMICT00000009544.3">
        <property type="protein sequence ID" value="ENSMICP00000008686.3"/>
        <property type="gene ID" value="ENSMICG00000009545.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182951"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055074">
        <property type="term" value="P:calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070166">
        <property type="term" value="P:enamel mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044691">
        <property type="term" value="P:tooth eruption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10469">
        <property type="entry name" value="FAM20A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024869">
        <property type="entry name" value="FAM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009581">
        <property type="entry name" value="FAM20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450">
        <property type="entry name" value="DENTIN MATRIX PROTEIN 4 PROTEIN FAM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12450:SF12">
        <property type="entry name" value="PSEUDOKINASE FAM20A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06702">
        <property type="entry name" value="Fam20C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM20 C-terminal" evidence="10">
        <location>
            <begin position="304"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="43"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="340"/>
            <end position="343"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="414"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="429"/>
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        <ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
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        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006557"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF06702"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008686.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="532" mass="60364" checksum="35C274CDDAB4BCF8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V348</accession>
    <name>A0A8C5V348_MICMU</name>
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        <submittedName>
            <fullName evidence="6">Izumo sperm-oocyte fusion 1</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">IZUMO1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Izumo family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V348"/>
    <dbReference type="Ensembl" id="ENSMICT00000013232.3">
        <property type="protein sequence ID" value="ENSMICP00000012065.3"/>
        <property type="gene ID" value="ENSMICG00000013241.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015014"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002080">
        <property type="term" value="C:acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086080">
        <property type="term" value="F:protein binding involved in heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035036">
        <property type="term" value="P:sperm-egg recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029389">
        <property type="entry name" value="IZUMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032699">
        <property type="entry name" value="Izumo-Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032700">
        <property type="entry name" value="IZUMO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35540">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35540:SF1">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15005">
        <property type="entry name" value="IZUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16706">
        <property type="entry name" value="Izumo-Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034086806" evidence="4">
        <location>
            <begin position="22"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="176"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012065.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="346" mass="38787" checksum="D7732D218886327A" modified="2022-01-19" version="1">MRPSFALLLAALARCLLPAGGCVTCSPLIEQALKSLKEDYLPGHLDVQHHQNVMERVEKAINDFKDLPLDANSFMGAVDEATLNKASWSLLKDLNRITDSDVKGELFVKELFWMLHLQKETFANFAAQFQKEAYCPNKCGTMYQTLIWCSNCEKQIHACRKSSNCGEREVVVHQMEDMILDCELSWHKASEGLTSYKFYRVWANNTEDLVTTGSASTLTKPMVDAKDAGRYRCELGSVNSSPATIMYFNVTVLPKRGEEEESSPNAVTQGKEDRLLSNNVTQGKEETPPPNTSPSDWYDIPAFNTPLPVEKTLKVRLAGGVPHSIKKVINFIKSLFRFGKRPAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3E6</accession>
    <name>A0A8C5V3E6_MICMU</name>
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        <submittedName>
            <fullName evidence="1">Ciliary microtubule associated protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">CIMAP3</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03002932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3E6"/>
    <dbReference type="Ensembl" id="ENSMICT00000011962.3">
        <property type="protein sequence ID" value="ENSMICP00000010891.2"/>
        <property type="gene ID" value="ENSMICG00000011967.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001017"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060971">
        <property type="term" value="P:embryonic heart tube left/right pattern formation"/>
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    <dbReference type="GO" id="GO:0031344">
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="CIMAP3"/>
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    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31508">
        <property type="entry name" value="PROTEIN PITCHFORK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31508:SF2">
        <property type="entry name" value="PROTEIN PITCHFORK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010891.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="23538" checksum="ABCB8432FD211383" modified="2022-01-19" version="1">CRRKYSSPLSTELLQPGFCAANKSSFGTRQHRKLFPLYHPPNLFGNKFLPIRGSPHIGPGCYVPEDRNDLAYNLSKIPTSVKGYTLGARTAVRFKPTNKDVTLYPGMYQKVRLQEEKHKQSFAPFNALVPRFRSYSKDTYCPGPGTYNPEMKPHPKVAWPMRFGSPDWAQVPCIQKRTFKTELSTDKDFRKHRNRVAYLSLFYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V471</accession>
    <name>A0A8C5V471_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Gamma-aminobutyric acid receptor subunit rho-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">GABA(A) receptor subunit rho-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">GABA(C) receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">GABRR1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Three rho subunits (rho-1/GBRR1, rho-2/GBRR2 and rho-3/GBRR3) coassemble either to form functional homopentamers or heteropentamers. Rho-1/GBRR1 subunits can also associate with alpha-1/GBRA1 subunits to form a functional GABAAR. Interacts with SQSTM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Postsynaptic cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRR1 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007636">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V471"/>
    <dbReference type="Ensembl" id="ENSMICT00000013039.3">
        <property type="protein sequence ID" value="ENSMICP00000011885.2"/>
        <property type="gene ID" value="ENSMICG00000013041.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158591"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19005">
        <property type="entry name" value="LGIC_ECD_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19059">
        <property type="entry name" value="LGIC_TM_GABAAR_rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000015">
        <property type="entry name" value="gamma-aminobutyric acid receptor subunit rho-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000005">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit rho-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008058">
        <property type="entry name" value="GABAAa_rho1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008057">
        <property type="entry name" value="GABAAa_rho_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01670">
        <property type="entry name" value="GABAARRHO"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01671">
        <property type="entry name" value="GABAARRHO1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0868">Chloride</keyword>
    <keyword evidence="10" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 22" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034841844" description="Gamma-aminobutyric acid receptor subunit rho-1" evidence="22">
        <location>
            <begin position="22"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="23">
        <location>
            <begin position="64"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="24">
        <location>
            <begin position="271"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00064308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011885.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="464" mass="53863" checksum="BD801488598CCAC4" modified="2022-01-19" version="1">MWTVQNMKFGVFLLWWGWVLATESRVHWPGREVHEMSKKGSPILKRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCAGGLPPPRAVMLDGSYSDGEVNDLDSYMPDNDNGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V487</accession>
    <name>A0A8C5V487_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MMS22-like</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methyl methanesulfonate-sensitivity protein 22-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MMS22L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication. It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs. Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination. Within the complex, MMS22L acts by binding ssDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MMS22 family. MMS22L subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007705">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007706">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007707">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624882.1">
        <property type="nucleotide sequence ID" value="XM_012769428.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624883.1">
        <property type="nucleotide sequence ID" value="XM_012769429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V487"/>
    <dbReference type="Ensembl" id="ENSMICT00000015766.3">
        <property type="protein sequence ID" value="ENSMICP00000014365.3"/>
        <property type="gene ID" value="ENSMICG00000015759.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874014"/>
    <dbReference type="KEGG" id="mmur:105874014"/>
    <dbReference type="CTD" id="253714"/>
    <dbReference type="GeneTree" id="ENSGT00390000011769"/>
    <dbReference type="OrthoDB" id="8193282at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042320">
        <property type="entry name" value="MMS22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029424">
        <property type="entry name" value="MMS22L_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029425">
        <property type="entry name" value="MMS22L_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28547:SF1">
        <property type="entry name" value="PROTEIN MMS22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14911">
        <property type="entry name" value="MMS22L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14910">
        <property type="entry name" value="MMS22L_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein MMS22-like N-terminal" evidence="12">
        <location>
            <begin position="26"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="MMS22-like C-terminal" evidence="13">
        <location>
            <begin position="850"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014365.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1242" mass="142155" checksum="1148C08D658DC104" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5P3</accession>
    <name>A0A8C5V5P3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stratifin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SFN</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001819">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606116.1">
        <property type="nucleotide sequence ID" value="XM_012750662.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5P3"/>
    <dbReference type="Ensembl" id="ENSMICT00000015640.3">
        <property type="protein sequence ID" value="ENSMICP00000014250.1"/>
        <property type="gene ID" value="ENSMICG00000015648.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863511"/>
    <dbReference type="KEGG" id="mmur:105863511"/>
    <dbReference type="CTD" id="2810"/>
    <dbReference type="GeneTree" id="ENSGT01090000260040"/>
    <dbReference type="OMA" id="ECRVFYL"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050815">
        <property type="term" value="F:phosphoserine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140311">
        <property type="term" value="F:protein sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141156">
        <property type="term" value="P:cAMP/PKA signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051715">
        <property type="term" value="P:cytolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003334">
        <property type="term" value="P:keratinocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010839">
        <property type="term" value="P:negative regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903077">
        <property type="term" value="P:negative regulation of protein localization to plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000647">
        <property type="term" value="P:negative regulation of stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160075">
        <property type="term" value="P:non-canonical inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045606">
        <property type="term" value="P:positive regulation of epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046827">
        <property type="term" value="P:positive regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022407">
        <property type="term" value="P:regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010482">
        <property type="term" value="P:regulation of epidermal cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd10019">
        <property type="entry name" value="14-3-3_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037435">
        <property type="entry name" value="14-3-3_sigma"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="248" mass="27830" checksum="B4623D2436237033" modified="2022-01-19" version="1">MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGLRAGWRVLSSIEQKSNEEGSEDKGPEVREYREKVETELRGVCDTVLGLLDSHLIKESGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARAAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGVEVPEEPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7I8</accession>
    <name>A0A8C5V7I8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105858380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596940.2">
        <property type="nucleotide sequence ID" value="XM_012741486.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7I8"/>
    <dbReference type="Ensembl" id="ENSMICT00000013200.3">
        <property type="protein sequence ID" value="ENSMICP00000012037.3"/>
        <property type="gene ID" value="ENSMICG00000013206.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008117"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013600">
        <property type="entry name" value="Ly49_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052013">
        <property type="entry name" value="Mouse_KLRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46329">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46329:SF1">
        <property type="entry name" value="KILLER CELL LECTIN-LIKE RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08391">
        <property type="entry name" value="Ly49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="12">
        <location>
            <begin position="154"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012037.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="281" mass="32135" checksum="170F4359C817C54E" modified="2022-01-19" version="1">MSDQGVIYSTVRFLQSSSESESGRSPDVTLRPEKTDDKEFSVSWRLIAVSLGILCLVLLVIVTVLVTKIFQCIQERHQQQEILGHLSQKDNYLKEQLLINKTLEYDILKNESLQQKKKLDSLFLKNNICHIKNEIFSKSLENTGKRYEAHWTCCGLSCYYFAVENKNWKGCKQTCQSYKSSLLKIDDEDELTFVQLQIYKNNYWIGLSYDERESKWKWVDSGSSPGINVGIMNSSSGRGKCGFLSSTRVAAIDCIQTYNCICEKRIGCSIFSASACTEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7Z6</accession>
    <name>A0A8C5V7Z6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC109731161</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03014315">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="16">
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    <feature type="compositionally biased region" description="Basic residues" evidence="16">
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    </feature>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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            <shortName evidence="10">ATPase subunit d</shortName>
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        <name evidence="11" type="primary">ATP5PD</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
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                <person name="Han Y."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="11" key="3">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="10">Subunit d, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase d subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 16"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:proton-transporting ATP synthase complex"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015925.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="150" mass="17469" checksum="2B2B373B2CCFBF21" modified="2022-01-19" version="1">MAGRKLALKTIDWVAFGEIIPRNQKAIANNLKSWNETLTSRSSVSKKKKLKCILASSWDKKYFNALKVPVPEDKYTALVDAEEKEDVKTCAEFVSLSKARIEEYEKELEKMRNIIPFDQMTIEDLNEAFPETKLDKEKYPYWPHQPIENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VA90</accession>
    <name>A0A8C5VA90_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">rRNA N(6)-adenosine-methyltransferase ZCCHC4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Zinc finger CCHC domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZCCHC4</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZCCHC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005487">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005488">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VA90"/>
    <dbReference type="SMR" id="A0A8C5VA90"/>
    <dbReference type="Ensembl" id="ENSMICT00000017184.3">
        <property type="protein sequence ID" value="ENSMICP00000015654.3"/>
        <property type="gene ID" value="ENSMICG00000017179.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012556"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041370">
        <property type="entry name" value="Mlase_EEF1AKMT1/ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039846">
        <property type="entry name" value="ZCCHC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493:SF3">
        <property type="entry name" value="RRNA N6-ADENOSINE-METHYLTRANSFERASE ZCCHC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13493">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10237">
        <property type="entry name" value="N6-adenineMlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="17">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="422"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015654.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="469" mass="55038" checksum="2C7FD98E19F359F5" modified="2022-01-19" version="1">ATLLFVKVQGKEETRRFYACSACRDRKDCNFFQWEDEKLSEARLAAREAHNRRCQPHLSRRQCVERYLKFIELPLTQRKFCQRCQQLLLPDEWGRHREHQVMGDISITQLRRPSQLLYPLENKKANAQYLFADRSCQFLVDLLSALGFRRVLCVGTPRLHELIMLTASGDKKSNIKSLLLDIDFRYSQFYMEDSFCHYNMFNHHFFDGKAALEICRAFLQEDEGEGVIMVTDPPFGGLVEPLAVTFKKLIAMWKEGQSQDDSHKELPIFWIFPYFFESRICQFFPSFCMLDYQVDYDNHALYKHGKTGRKQSPVRIFTNVPRNKIILPTEEGYRFCPLCQRYVSLENQHCEHCNSCTSKDGRKWNHCFLCKKCVKPSWIHCSICNRCALPGHSCEGPKDGCFICGELDHKRSTCPNIATPKRANKAVRKQKQRKSNKMKMETTKGQSMNHTSVTRKKKRRERAHQYLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAC3</accession>
    <name>A0A8C5VAC3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03017280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VAC3"/>
    <dbReference type="Ensembl" id="ENSMICT00000033031.2">
        <property type="protein sequence ID" value="ENSMICP00000017135.1"/>
        <property type="gene ID" value="ENSMICG00000027259.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000245573"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13135" checksum="BB5597EB16AB248D" modified="2022-01-19" version="1">MADEEENPTFEQENEEIGGGAEDRQGKRKRHFSEELSCMMYVDILENLDIEFITEMTQRAMAIGRQDRVQVEDLLFLMKFARVKDLLSVNEELKGASRRAFDEANYGSWHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBB7</accession>
    <name>A0A8C5VBB7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Laminin subunit gamma-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LAMC1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
            <location evidence="2">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029482">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029483">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029484">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029485">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029486">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029487">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591291.1">
        <property type="nucleotide sequence ID" value="XM_012735837.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000029659.2">
        <property type="protein sequence ID" value="ENSMICP00000019514.1"/>
        <property type="gene ID" value="ENSMICG00000007087.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855091"/>
    <dbReference type="KEGG" id="mmur:105855091"/>
    <dbReference type="CTD" id="3915"/>
    <dbReference type="GeneTree" id="ENSGT00940000158069"/>
    <dbReference type="OrthoDB" id="430826at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005201">
        <property type="term" value="F:extracellular matrix structural constituent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031581">
        <property type="term" value="P:hemidesmosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034446">
        <property type="term" value="P:substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00055">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000067">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000193">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000758">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000018">
        <property type="entry name" value="Laminin subunit gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000105">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000163">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000166">
        <property type="entry name" value="laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000174">
        <property type="entry name" value="Laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:001192">
        <property type="entry name" value="Laminin subunit gamma-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050440">
        <property type="entry name" value="Laminin/Netrin_ECM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000034">
        <property type="entry name" value="Laminin_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008211">
        <property type="entry name" value="Laminin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056863">
        <property type="entry name" value="LMN_ATRN_NET-like_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574:SF270">
        <property type="entry name" value="LAMININ SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10574">
        <property type="entry name" value="NETRIN/LAMININ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00053">
        <property type="entry name" value="EGF_laminin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24973">
        <property type="entry name" value="EGF_LMN_ATRN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00052">
        <property type="entry name" value="Laminin_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00055">
        <property type="entry name" value="Laminin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00011">
        <property type="entry name" value="EGFLAMININ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00180">
        <property type="entry name" value="EGF_Lam"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00281">
        <property type="entry name" value="LamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00136">
        <property type="entry name" value="LamNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50027">
        <property type="entry name" value="EGF_LAM_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51115">
        <property type="entry name" value="LAMININ_IVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51117">
        <property type="entry name" value="LAMININ_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0424">Laminin EGF-like domain</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150039" description="Laminin subunit gamma-1" evidence="17">
        <location>
            <begin position="35"/>
            <end position="1608"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin N-terminal" evidence="20">
        <location>
            <begin position="45"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="397"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="444"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin IV type A" evidence="19">
        <location>
            <begin position="520"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="723"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="827"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="883"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="18">
        <location>
            <begin position="982"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1067"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1228"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1453"/>
            <end position="1487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1543"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="936"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="982"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1608" mass="177824" checksum="C5C4E5889AE4A99A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEU0</accession>
    <name>A0A8C5VEU0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC105859914</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VEU0"/>
    <dbReference type="Ensembl" id="ENSMICT00000034675.2">
        <property type="protein sequence ID" value="ENSMICP00000018932.2"/>
        <property type="gene ID" value="ENSMICG00000032080.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286945"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15416">
        <property type="entry name" value="7tmA_OR5P-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="46"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018932.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="317" mass="35298" checksum="32336BE396799674" modified="2022-01-19" version="1">LAFLFPPDGNHTAVTGFTLLGLTDDPVLRVVLFMIILCIYLVTISGNLSTVILIRISSQLHHPMYFFLSHLASVDIGYSSSVTPNMLVNFLAEKNTISYLGCAIQLFSAAFFGTVECFLLAAMAYDRFVAICNPLLYSTKMSTQVCVQLLIVAYIGGFLNSSFFTFSFFSLSFCGPNQVNHFFCDFAPLIELSCFHTSVHTTVPSFSAGLVLMVTVLVIAVSYIYILITILKMRSTEGRHKAFSTCTSHLTAVTLFYGTTIFIYVMPKSSYSMDENKVVSVFYMVVIPMLNPLIYSLRNKEIKGALKRQLGRKIFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEZ1</accession>
    <name>A0A8C5VEZ1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03002299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VEZ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000031444.2">
        <property type="protein sequence ID" value="ENSMICP00000021305.1"/>
        <property type="gene ID" value="ENSMICG00000036237.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158947"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000096">
        <property type="entry name" value="KRAS proto-oncogene, GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="181" mass="20261" checksum="919DD10224E2E7E6" modified="2022-01-19" version="1">MSEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGKGFLCVFAINNSKSFADINLYREQIKQIKDSDDVPMVLVGNKCDLPTRRVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREMRHSDDGTQGCMGLPCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VF62</accession>
    <name>A0A8C5VF62_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LY6/PLAUR domain containing 6B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LYPD6B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VF62"/>
    <dbReference type="Ensembl" id="ENSMICT00000030176.2">
        <property type="protein sequence ID" value="ENSMICP00000018524.1"/>
        <property type="gene ID" value="ENSMICG00000016688.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000220"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030548">
        <property type="term" value="F:acetylcholine receptor regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23626">
        <property type="entry name" value="TFP_LU_ECD_LYPD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000004">
        <property type="entry name" value="Ly6/PLAUR domain-containing protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039457">
        <property type="entry name" value="LYPD6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31171">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31171:SF3">
        <property type="entry name" value="LY6_PLAUR DOMAIN-CONTAINING PROTEIN 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16975">
        <property type="entry name" value="UPAR_LY6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="183" mass="20798" checksum="0113F5AA2FEB1A2B" modified="2022-01-19" version="1">MLFLRLDRPKHEVTMLPLCHALAVAVVQLFIFSENWAFAKNINFYNVRPPLDPTPFPNSFKCFTCENAADNYNCNRWAEDKWCPQNTQYCLTVHHFNSRGRSTSITKKCASKTECHFVGCHRSQGSEHTECRSCCEGMICNVELPTNHTNAVFAIMHAQRASGSSVPVPCLPVLVWVFVLPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHL5</accession>
    <name>A0A8C5VHL5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Transient receptor potential cation channel subfamily C member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TRPC4</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03017767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017768">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017769">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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    <sequence length="977" mass="111974" checksum="1664B87EA18CEA31" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VIM4</accession>
    <name>A0A8C5VIM4_MICMU</name>
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        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor GTPase-activating protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger protein 289</fullName>
        </alternativeName>
    </protein>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005096">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0048205">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
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        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN 2"/>
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    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
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    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="19">
        <location>
            <begin position="11"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="137"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020460.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="507" mass="55128" checksum="3F93D31BEA6FD102" modified="2022-01-19" version="1">MAAEPSKTEIQTLFKRLRAIPTNKACFDCGAKNPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNANATAFFRQHGCTASDANTKYNSRAAQMYREKIRQLGSAALARHGTDLWIDNMSSAPSHSPEKKDSDFFTEHTQPPAWDVSATEPSGMQQAAPSAESSGLAPTEPEHGPNTDLLGTSPKATLEPKSSIIGKKKPAAAKKGLGAKKGLGAQKVSSQSFSEIERQAQVAEKLREQQAADAKKQAEESMVASMRPAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSVSHTVLSEMQVIEQETPVSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGESFGSRWDTDAAWDMDRVEEKEPEVTISSIRPISERSSEARQKFAGAKAISSDMFFGREVDVEYEARSRLQQLSGSSAISSSDLFGDMDGAHGAGSVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM47</accession>
    <name>A0A8C5VM47_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="6">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">eIF-3-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">eIF3 p35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">EIF3J</name>
        <name evidence="6" type="synonym">EIF3S1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit binds directly within the mRNA entry channel of the 40S ribosome to the aminoacyl (A) site. It may regulate the interaction between the 43S PIC and mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Phosphorylated. Phosphorylation is enhanced upon serum stimulation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004662">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM47"/>
    <dbReference type="Ensembl" id="ENSMICT00000037216.2">
        <property type="protein sequence ID" value="ENSMICP00000025096.1"/>
        <property type="gene ID" value="ENSMICG00000005006.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018400"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Promotes stable association with the 40S ribosome" evidence="6">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="210" mass="23172" checksum="A85BD832DB010DCF" modified="2022-01-19" version="1">MAAAAAAAGDSDSWDADTFSVEDPVRKVGGGGGTAGGDRWEGEDEDEDVKLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGINNTVYGIDAMNPSSREDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VUG1</accession>
    <name>A0A8C5VUG1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MYB proto-onco like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MYBL1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Transcriptional activator Myb isoform A"/>
        <property type="match status" value="1"/>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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            <location evidence="1">Endomembrane system</location>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Small_GTPase"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032161.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Homeobox even-skipped homolog protein 2</fullName>
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        <alternativeName>
            <fullName evidence="8">EVX-2</fullName>
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    </protein>
    <gene>
        <name evidence="13" type="primary">EVX2</name>
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    <organism evidence="13 14">
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        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the even-skipped homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608898.1">
        <property type="nucleotide sequence ID" value="XM_012753444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VXY6"/>
    <dbReference type="Ensembl" id="ENSMICT00000036960.2">
        <property type="protein sequence ID" value="ENSMICP00000032733.1"/>
        <property type="gene ID" value="ENSMICG00000035343.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105865088"/>
    <dbReference type="KEGG" id="mmur:105865088"/>
    <dbReference type="CTD" id="344191"/>
    <dbReference type="GeneTree" id="ENSGT00940000161025"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000367">
        <property type="entry name" value="homeobox even-skipped homolog protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052002">
        <property type="entry name" value="Even-skipped_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294:SF1">
        <property type="entry name" value="HOMEOBOX EVEN-SKIPPED HOMOLOG PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46294">
        <property type="entry name" value="SEGMENTATION PROTEIN EVEN-SKIPPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="188"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="474" mass="47724" checksum="B872AABDFB9F2240" modified="2022-01-19" version="1">MMERIRKEMILMERGLHSPTAGKRFSNLSDSAGNAVLEALENSQHPARLSPRLPSAPLHGALGDLPAKGKFEIDTLFNLQHPGSESTVSSEIASVTESRKKPGHYSEAAAEADMSSDVEVGCSALRSPGGLGATPLKENNGKGYAESGSAAGTTTSASGSGLGSLHGGGGGSGGGAALGSSGSGADQVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMSWPHPADPSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAASGAAAAASSPFATSIRPLDTFRALSHPYSRPELLCSFRHPGLYQAPAAAAGLNSAASAAAAAAAAAAAASSAAAAGAPPSGGSAPCSCLSCHSSQSAAAAAAAAAAALGSRGGGGGGGGGGGGSGAGATGGSDFGCSAAAPRSESGFLPYSAAVLSKTAVSPPDQRDEAPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W052</accession>
    <name>A0A8C5W052_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Stromal cell-derived factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">C-X-C motif chemokine 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Pre-B cell growth-stimulating factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CXCL12</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form. Interacts with the N-terminus of ACKR3. Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)). Interacts with TNFAIP6 (via Link domain).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019094">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W052"/>
    <dbReference type="Ensembl" id="ENSMICT00000032037.2">
        <property type="protein sequence ID" value="ENSMICP00000033941.2"/>
        <property type="gene ID" value="ENSMICG00000011935.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014056"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090280">
        <property type="term" value="P:positive regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050921">
        <property type="term" value="P:positive regulation of chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000010">
        <property type="entry name" value="Stromal cell-derived factor 1 precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF193">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="5" id="KW-0202">Cytokine</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0339">Growth factor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034669095" description="Stromal cell-derived factor 1" evidence="13">
        <location>
            <begin position="22"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="14">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033941.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="140" mass="15579" checksum="70249B9A35B00977" modified="2022-01-19" version="1">MDCKVIAMLFLVLTAFCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTANCALQIVARLKSNNRQVCIDPKLKWIQEYLEKALNNLVSAALVGRRVMAGAPALRPSPPFACPTRALCEIHLRPPPERSRPSPGDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W496</accession>
    <name>A0A8C5W496_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024675">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W496"/>
    <dbReference type="Ensembl" id="ENSMICT00000038241.2">
        <property type="protein sequence ID" value="ENSMICP00000033538.2"/>
        <property type="gene ID" value="ENSMICG00000044801.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153520"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000721">
        <property type="entry name" value="Immunoglobulin lambda variable 5-45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033538.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="11953" checksum="46C94E3053B1E7D0" modified="2022-01-19" version="1">QPVLTQLPSLSVSPGASARLTCTLSSGFRVGDFWIRWYQQKPESPPRYLLTFHSDSDKHQGSGVPSRFSGSSDASTNAGILHISGLQPEDEADYYCNTYHGNSKTFTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W4V5</accession>
    <name>A0A8C5W4V5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphoethanolamine/phosphocholine phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PHOSPHO1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization. Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphocholine + H2O = choline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:295975"/>
            <dbReference type="EC" id="3.1.3.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>phosphoethanolamine + H2O = ethanolamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16089"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
            <dbReference type="ChEBI" id="CHEBI:58190"/>
            <dbReference type="EC" id="3.1.3.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Extracellular vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily. PHOSPHO family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.75" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03020096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W4V5"/>
    <dbReference type="Ensembl" id="ENSMICT00000036227.2">
        <property type="protein sequence ID" value="ENSMICP00000036791.1"/>
        <property type="gene ID" value="ENSMICG00000032861.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007741"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903561">
        <property type="term" value="C:extracellular vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052731">
        <property type="term" value="F:phosphocholine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052732">
        <property type="term" value="F:phosphoethanolamine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035630">
        <property type="term" value="P:bone mineralization involved in bone maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030500">
        <property type="term" value="P:regulation of bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16418">
        <property type="entry name" value="HAD_Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000097">
        <property type="entry name" value="phosphoethanolamine/phosphocholine phosphatase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006384">
        <property type="entry name" value="HAD_hydro_PyrdxlP_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016965">
        <property type="entry name" value="Pase_PHOSPHO-typ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01489">
        <property type="entry name" value="DKMTPPase-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889">
        <property type="entry name" value="PHOSPHATASE, ORPHAN 1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20889:SF2">
        <property type="entry name" value="PHOSPHOETHANOLAMINE_PHOSPHOCHOLINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06888">
        <property type="entry name" value="Put_Phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031051">
        <property type="entry name" value="PyrdxlP_Pase_PHOSPHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0495">Mineral balance</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00084103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR031051-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="293" mass="32508" checksum="F02840D3A031DCB1" modified="2022-01-19" version="1">MCQHPWPWPANQPLPGRLPPRLLSLAPSSFSCYSPPCSQDGGMAAQGAPRFLLIFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLRAVYEAIPLSPGMADLLQFVAKQGACFEVILISDANTFGVESALRAAGHHGLFRRILSNPSGPDARGLLALRPFHTHSCTRCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRHGYPMHRLIQEAQKAEPSSVRANVVPWETAADVRLHLQQFSSTANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W4W6</accession>
    <name>A0A8C5W4W6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W4W6"/>
    <dbReference type="Ensembl" id="ENSMICT00000002070.3">
        <property type="protein sequence ID" value="ENSMICP00000033281.1"/>
        <property type="gene ID" value="ENSMICG00000002072.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006548"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="14392" checksum="6445DAD1BBD81F2A" modified="2022-01-19" version="1">MGHVCTKTKYYTRLGNDFHTDKDVCEEIAIIPSKKLHNKIAGYVTHLMKRIQRGPVRDISIKLQEEERERRDNYVPEVSALDQEIIEVVPDTKEMLKLFDFGSLSNLQVTQPTVGMNFKTQRGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W7N1</accession>
    <name>A0A8C5W7N1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">N-acetylated-alpha-linked acidic dipeptidase 2</fullName>
            <ecNumber evidence="21">3.4.17.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Glutamate carboxypeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">N-acetylated-alpha-linked acidic dipeptidase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">NAALAD2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates.</text>
            <dbReference type="EC" id="3.4.17.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.21" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03006632">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W7N1"/>
    <dbReference type="Ensembl" id="ENSMICT00000017534.3">
        <property type="protein sequence ID" value="ENSMICP00000015969.3"/>
        <property type="gene ID" value="ENSMICG00000015630.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000043249.2">
        <property type="protein sequence ID" value="ENSMICP00000035387.1"/>
        <property type="gene ID" value="ENSMICG00000015630.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234598"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000291">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.40:FF:000001">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000002">
        <property type="entry name" value="N-acetylated-alpha-linked acidic dipeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF38">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="26">
        <location>
            <begin position="161"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="28">
        <location>
            <begin position="347"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="27">
        <location>
            <begin position="617"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00066561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00080488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="741" mass="83713" checksum="FE458A8CAEB9659E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W8S5</accession>
    <name>A0A8C5W8S5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STARD3 N-terminal like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">STARD3NL</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STARD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015733">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633046.1">
        <property type="nucleotide sequence ID" value="XM_012777592.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633047.1">
        <property type="nucleotide sequence ID" value="XM_012777593.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W8S5"/>
    <dbReference type="Ensembl" id="ENSMICT00000046700.2">
        <property type="protein sequence ID" value="ENSMICP00000036299.1"/>
        <property type="gene ID" value="ENSMICG00000000945.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069609.1">
        <property type="protein sequence ID" value="ENSMICP00000041113.1"/>
        <property type="gene ID" value="ENSMICG00000000945.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070107.1">
        <property type="protein sequence ID" value="ENSMICP00000041235.1"/>
        <property type="gene ID" value="ENSMICG00000000945.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878251"/>
    <dbReference type="KEGG" id="mmur:105878251"/>
    <dbReference type="CTD" id="83930"/>
    <dbReference type="GeneTree" id="ENSGT00940000155476"/>
    <dbReference type="OMA" id="HWWAVAI"/>
    <dbReference type="OrthoDB" id="5912992at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019498">
        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF1">
        <property type="entry name" value="STARD3 N-TERMINAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51439">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="7">
        <location>
            <begin position="48"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="234" mass="26540" checksum="AF2033BCE7603F47" modified="2022-01-19" version="1">MNHLPEDMENVLTGSQSSHASVRSVHSINPTQLMARIESYEGREKKGISDVRRTFCLFVTFDLLFVTLLWIIELNVNGGIENTLEREVVQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAVALTTAVTSAFLLAKVILSKLFSQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEEENRLLIVQDASESAALLPGGLSDGQFYSPPESEAGSEEAEEKQDSEKPLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W973</accession>
    <name>A0A8C5W973_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="30">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">LOC105860485</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2E)-geranial + NADPH + O2 + H(+) = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54860"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:54861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>NADPH + O2 + H(+) = H2O2 + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:11260"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.6.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:11261"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>heptan-2-one + NADPH + O2 + H(+) = pentyl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54836"/>
            <dbReference type="ChEBI" id="CHEBI:5672"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:87362"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54837"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>heptan-4-one + NADPH + O2 + H(+) = propyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54852"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89484"/>
            <dbReference type="ChEBI" id="CHEBI:89719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:54853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexan-3-one + NADPH + O2 + H(+) = ethyl butanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54844"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:88764"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:54845"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexan-3-one + NADPH + O2 + H(+) = propyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54848"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:89828"/>
            <dbReference type="ChEBI" id="CHEBI:89891"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54849"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>octan-3-one + NADPH + O2 + H(+) = ethyl hexanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:86055"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:54857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octan-3-one + NADPH + O2 + H(+) = pentyl propanoate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:80946"/>
            <dbReference type="ChEBI" id="CHEBI:87373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54841"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>sulcatone + NADPH + O2 + H(+) = 4-methylpent-3-en-1-yl acetate + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:54864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16310"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:138373"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54865"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 29 30">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 29">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 29 30">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="30"/>
    <dbReference type="EMBL" id="ABDC03003316">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600747.1">
        <property type="nucleotide sequence ID" value="XM_012745293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W973"/>
    <dbReference type="Ensembl" id="ENSMICT00000039537.2">
        <property type="protein sequence ID" value="ENSMICP00000035054.1"/>
        <property type="gene ID" value="ENSMICG00000032977.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105860485"/>
    <dbReference type="GeneTree" id="ENSGT00940000160836"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000042">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000073">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000409">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002257">
        <property type="entry name" value="Flavin_mOase_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01125">
        <property type="entry name" value="FMOXYGENASE5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 29" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 29 30" id="KW-0274">FAD</keyword>
    <keyword evidence="7 29 30" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17 29 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 29 30" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="12 29" id="KW-0521">NADP</keyword>
    <keyword evidence="14 29 30" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 31" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="543" mass="62122" checksum="41A0BD443F60ECCC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WBK4</accession>
    <name>A0A8C5WBK4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AP4S1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004315">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004316">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004317">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WBK4"/>
    <dbReference type="SMR" id="A0A8C5WBK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000051982.2">
        <property type="protein sequence ID" value="ENSMICP00000037038.1"/>
        <property type="gene ID" value="ENSMICG00000003359.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00970000193421"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14832">
        <property type="entry name" value="AP4_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="9">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="144" mass="17005" checksum="0B620AFBB3B7F8A1" modified="2022-01-19" version="1">MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XBA4</accession>
    <name>A0A8C5XBA4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lamin tail domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LMNTD2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005979">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XBA4"/>
    <dbReference type="Ensembl" id="ENSMICT00000002434.3">
        <property type="protein sequence ID" value="ENSMICP00000002223.3"/>
        <property type="gene ID" value="ENSMICG00000002435.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012150"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005638">
        <property type="term" value="C:lamin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1260">
        <property type="entry name" value="Lamin Tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052877">
        <property type="entry name" value="Lamin_tail_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19956">
        <property type="entry name" value="LAMIN TAIL DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19956:SF5">
        <property type="entry name" value="LAMIN TAIL DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="Lamin A/C globular tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LTD" evidence="3">
        <location>
            <begin position="362"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="112"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002223.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="637" mass="70681" checksum="611BD27365CFB3AF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XBL5</accession>
    <name>A0A8C5XBL5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Aprataxin and PNK-like factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Apurinic-apyrimidinic endonuclease APLF</fullName>
        </alternativeName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="19">Interacts with LIG4. Interacts with PARP1. Interacts with XRCC4. Interacts (via KBM motif) with XRCC5 and XRCC6; promoting recruitment to DNA damage sites. Interacts with XRCC1. Interacts (via C-terminal disordered region) with histones; interacts with histone H2A, H2B and H3-H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the APLF family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XBL5"/>
    <dbReference type="Ensembl" id="ENSMICT00000003734.3">
        <property type="protein sequence ID" value="ENSMICP00000003402.3"/>
        <property type="gene ID" value="ENSMICG00000003735.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010591"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22717">
        <property type="entry name" value="FHA_APLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000026">
        <property type="entry name" value="Aprataxin and PNKP like factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039253">
        <property type="entry name" value="APLF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041388">
        <property type="entry name" value="FHA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315:SF2">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21315">
        <property type="entry name" value="APRATAXIN AND PNK-LIKE FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17913">
        <property type="entry name" value="FHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PNK FHA" evidence="23">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00071713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00083724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF17913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003402.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="276" mass="30384" checksum="CA64CDB5676679E1" modified="2022-01-19" version="1">MSGGFELQPQDGGPRVALAPGETVIGRGPLLGITDKRVSRRHAILEVVSGQLRIKPIHTNPCFYQSSEKSQLLPLKTNLWRWLNPGDSFSLLVDKYIFRVLSTHSEMEMECTLRNSQMLDEDDILKETPNSPVINLPDETTGASQLERSTEITETQTTTTESVSFLGECRDFSKQQTDLSQRKRILPAWMLAENLSDQNLSAPVISGDNNVIQGSGKEGICKDKTKVNIIQQGRKRLISSGSSESTSAEQDTGKKSKNANQEESVISSKNSSICAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDE4</accession>
    <name>A0A8C5XDE4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC6A18</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629581.1">
        <property type="nucleotide sequence ID" value="XM_012774127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDE4"/>
    <dbReference type="Ensembl" id="ENSMICT00000010871.3">
        <property type="protein sequence ID" value="ENSMICP00000009905.2"/>
        <property type="gene ID" value="ENSMICG00000010877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876453"/>
    <dbReference type="KEGG" id="mmur:105876453"/>
    <dbReference type="CTD" id="348932"/>
    <dbReference type="GeneTree" id="ENSGT00940000158906"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140931">
        <property type="term" value="F:neutral L-amino acid:sodium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990297">
        <property type="term" value="P:renal amino acid absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002438">
        <property type="entry name" value="Neutral_aa_SLC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF109">
        <property type="entry name" value="INACTIVE SODIUM-DEPENDENT NEUTRAL AMINO ACID TRANSPORTER B(0)AT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01206">
        <property type="entry name" value="ORPHTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 10" id="KW-0769">Symport</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="482"/>
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        <location>
            <begin position="575"/>
            <end position="600"/>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
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        <location>
            <position position="43"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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            <position position="44"/>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
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            <name>Na(+)</name>
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            <name>Na(+)</name>
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            <name>Na(+)</name>
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        <source>
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        <source>
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    <sequence length="615" mass="68208" checksum="CFE7CE47982A1D70" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDG8</accession>
    <name>A0A8C5XDG8_MICMU</name>
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        <submittedName>
            <fullName evidence="15">Rap guanine nucleotide exchange factor 6</fullName>
        </submittedName>
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    <gene>
        <name evidence="15" type="primary">RAPGEF6</name>
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    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
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            <location evidence="2">Cytoplasm</location>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="Ensembl"/>
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        <location>
            <begin position="37"/>
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    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
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    <feature type="region of interest" description="Disordered" evidence="9">
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        <location>
            <begin position="1242"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1436"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1575"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1263"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1302"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1575"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1602"/>
            <end position="1613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010161.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1613" mass="180447" checksum="10CADD8C41CCE5C4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XIF8</accession>
    <name>A0A8C5XIF8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein S100-A14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">S100 calcium-binding protein A14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">S100A14</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Interacts with AGER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646711.1">
        <property type="nucleotide sequence ID" value="XM_012791257.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646712.1">
        <property type="nucleotide sequence ID" value="XM_012791258.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646714.1">
        <property type="nucleotide sequence ID" value="XM_012791260.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646715.1">
        <property type="nucleotide sequence ID" value="XM_012791261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XIF8"/>
    <dbReference type="Ensembl" id="ENSMICT00000039670.2">
        <property type="protein sequence ID" value="ENSMICP00000025812.1"/>
        <property type="gene ID" value="ENSMICG00000031104.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885930"/>
    <dbReference type="KEGG" id="mmur:105885930"/>
    <dbReference type="CTD" id="57402"/>
    <dbReference type="GeneTree" id="ENSGT00940000161706"/>
    <dbReference type="OrthoDB" id="9402565at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042379">
        <property type="term" value="F:chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071624">
        <property type="term" value="P:positive regulation of granulocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090026">
        <property type="term" value="P:positive regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05022">
        <property type="entry name" value="S-100A13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000221">
        <property type="entry name" value="Protein S100-A14 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF4">
        <property type="entry name" value="PROTEIN S100-A14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S100/CaBP-9k-type calcium binding subdomain" evidence="9">
        <location>
            <begin position="18"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00076814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="104" mass="11416" checksum="D8B1C1BB7B25F4A9" modified="2022-01-19" version="1">MGQCRSANAEDAQEFSDVERAIETLIKNFHQYSVEGGKETLTPSELRDLVTQQLPHLMPSNCGLEEKIANLGNCSDSKLEFGSFWELIGEAAKSVKLESPARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJ41</accession>
    <name>A0A8C5XJ41_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ILEI/PANDER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001529">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJ41"/>
    <dbReference type="Ensembl" id="ENSMICT00000026852.2">
        <property type="protein sequence ID" value="ENSMICP00000027578.1"/>
        <property type="gene ID" value="ENSMICG00000038639.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063632"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047223">
        <property type="term" value="F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016266">
        <property type="term" value="P:protein O-linked glycosylation via N-acetyl-galactosamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039477">
        <property type="entry name" value="ILEI/PANDER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052463">
        <property type="entry name" value="O-linked_mannose_GnT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46396:SF1">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15711">
        <property type="entry name" value="ILEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52031">
        <property type="entry name" value="GG_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="ILEI/PANDER" evidence="4">
        <location>
            <begin position="129"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="200" mass="22559" checksum="DB20ED9B75EF8D8B" modified="2022-01-19" version="1">MDDWKPSPLIKPFGARKKRSWYLTWKYKLTNQRTLRRFCQTGAVLFLLVTVIVNIKLILDTRRAIGEANEDPEPEQDYDEALGHLEPSRRRVSGPQRVLDVEVYSSRSKVYVAVDGTTVLEDEAREQGRGIHVIVLNQATGHVMAKRVFDTYSPHEDEAMVLFLNMVAPGRVLICTVKVLSSGRNILSHLPSLPGGTQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJ69</accession>
    <name>A0A8C5XJ69_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium channel flower domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CACFD1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel flower family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJ69"/>
    <dbReference type="Ensembl" id="ENSMICT00000046795.2">
        <property type="protein sequence ID" value="ENSMICP00000027814.1"/>
        <property type="gene ID" value="ENSMICG00000031108.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000529"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="130" mass="13590" checksum="3C2953436629A26F" modified="2022-01-19" version="1">MSGSAGAASASASSAPPAQEEGMTWWYRWLCRLSGVLGAVSCAISGLFNCVTIHPLNIAAGVWMMMAVVPVVISLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETLEGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XKW8</accession>
    <name>A0A8C5XKW8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositol-3-phosphate synthase 1</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Myo-inositol 1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ISYNA1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03027605">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139455.1">
        <property type="nucleotide sequence ID" value="XM_020283866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XKW8"/>
    <dbReference type="Ensembl" id="ENSMICT00000054683.2">
        <property type="protein sequence ID" value="ENSMICP00000032844.2"/>
        <property type="gene ID" value="ENSMICG00000017023.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105855018"/>
    <dbReference type="CTD" id="51477"/>
    <dbReference type="GeneTree" id="ENSGT00390000018395"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000171">
        <property type="entry name" value="inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="19">
        <location>
            <begin position="307"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032844.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="559" mass="60917" checksum="B760431BF8139456" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XN21</accession>
    <name>A0A8C5XN21_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Hyaluronidase</fullName>
            <ecNumber evidence="10">3.2.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">HYAL4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.</text>
            <dbReference type="EC" id="3.2.1.35"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 10">Belongs to the glycosyl hydrolase 56 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.35" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03015272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XN21"/>
    <dbReference type="GlyCosmos" id="A0A8C5XN21">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000033710.2">
        <property type="protein sequence ID" value="ENSMICP00000038026.2"/>
        <property type="gene ID" value="ENSMICG00000030714.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230364"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004415">
        <property type="term" value="F:hyalurononglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030207">
        <property type="term" value="P:chondroitin sulfate proteoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030214">
        <property type="term" value="P:hyaluronan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000065">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018155">
        <property type="entry name" value="Hyaluronidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769">
        <property type="entry name" value="HYALURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11769:SF7">
        <property type="entry name" value="HYALURONIDASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01630">
        <property type="entry name" value="Glyco_hydro_56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038193">
        <property type="entry name" value="Hyaluronidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00846">
        <property type="entry name" value="GLHYDRLASE56"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00848">
        <property type="entry name" value="SPERMPH20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="8">
        <location>
            <position position="368"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="59"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="381"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038193-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU610713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038026.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="481" mass="54639" checksum="8E1C16C1BB88CB2F" modified="2022-01-19" version="1">MKLLSEGQLKLCVVQPVHLTSWLFIFFILKSMSSLKPARLPIYQRKPFIAAWNAPTDQCLIKYNLRLNLKMFQVIGSPLAKARGQNVTIFYVNRLGYYPWYTSEGVPINGGLPQNISLQVHLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNTKDVYRQKSRKLISDMQRNGSATDIEYLAKATFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNIYAPNYTGSCPEEEVLRNNELSWLWNSSAALYPSIGVRKFLGDSENILRFSQFRVHESMRISTMTCHDYALPVFVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTSSEGNCTKVKQFVSSDLGSYIVNVTRAAEACSRHLCRNNGRCIRKMWKAPDYLHLNPASYHIEASENGEFTVKGKTSDTDLAEMAEKFSCHCYQGYEGADCREMKPADGCSGVSPFSGSLITLCLLVLAGYGNILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XN85</accession>
    <name>A0A8C5XN85_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">E3 ubiquitin-protein ligase FANCL</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase FANCL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FANCL</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03005040">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604142.1">
        <property type="nucleotide sequence ID" value="XM_012748688.3"/>
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        <property type="gene ID" value="ENSMICG00000015042.3"/>
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    <dbReference type="CTD" id="55120"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:Fanconi anaemia nuclear complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nuclear body"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase FANCL isoform X2"/>
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        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
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        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN PHF9 FANCONI ANEMIA GROUP L PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FANCL_d3"/>
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        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fanconi anemia complex subunit FancL WD-repeat containing" evidence="18">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
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            <end position="197"/>
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        <location>
            <begin position="200"/>
            <end position="294"/>
        </location>
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        <location>
            <begin position="304"/>
            <end position="371"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    <sequence length="375" mass="42803" checksum="255AD4E66DAE60D0" modified="2022-01-19" version="1">MAGTEASLLRQCPLLLPQNREKTVYEGFVSAQGRDFHLRILLPEDLQLKNARLLCSWQLRTILNGYHQIVQQRMQHSPDLMSFMMELKMVLEVALKNRQELYALPPPPQFYSSLIEEIGTLGWDKLVYVDTCFSTIKLKAEDASGREHLITLKLKAKYPAESPDCFVDFPIPFSVSWTPQSSLVNIHSQFLAALESLKAFWDVMDEIDEKTWVLEPEKPTRSVTARRIALGNNVSINIEVDPRHPTMLPECCFLGADHVVKPLGIKLSRNIHLWDPENSLLQNLKDVLEIDFPARAILEKSDFTMDCGICYAYQLDGAIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQSFNIIFGECPYCSKPITLKMSGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQC9</accession>
    <name>A0A8C5XQC9_MICMU</name>
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        <recommendedName>
            <fullName evidence="3">Lymphotoxin beta receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03010460">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQC9"/>
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        <property type="gene ID" value="ENSMICG00000030640.2"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="F:ubiquitin protein ligase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:hematopoietic or lymphoid organ development"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR017349">
        <property type="entry name" value="TNFR_3_LTBR"/>
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    <dbReference type="PANTHER" id="PTHR47607">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUBFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR47607:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="Ensembl" id="ENSMICP00000039434.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8359" checksum="CB80A8F9DD6F3339" modified="2022-01-19" version="1">MGLEEAAPCTNKQKTQCRCQPGMFCAAWALECTHCELLSDCPPGTEAEFKGVRTRAWWRQLQAPPSLTEAAEMNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XWP4</accession>
    <name>A0A8C5XWP4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03008495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XWP4"/>
    <dbReference type="Ensembl" id="ENSMICT00000063100.1">
        <property type="protein sequence ID" value="ENSMICP00000042604.1"/>
        <property type="gene ID" value="ENSMICG00000045997.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153467"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21234">
        <property type="entry name" value="CH_UTRN_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000118">
        <property type="entry name" value="Dystrophin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000032">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000075">
        <property type="entry name" value="utrophin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002017">
        <property type="entry name" value="Spectrin_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00435">
        <property type="entry name" value="Spectrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="5">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="424" mass="49105" checksum="F5F1B2BA86D39D0D" modified="2022-01-19" version="1">KITTFLMLNFKNCCLVSLKQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEEINIQSTAPEEERGSPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKLQLQQLSAWLTLTEERIQKMETCPLDDDLNALQKLLEEHKSLQNDLEAEQVKVNSLTHMVVIVDENSGESATAVLEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3Q7</accession>
    <name>A0A8C5Y3Q7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dpy-19 like C-mannosyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105859508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015613">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3Q7"/>
    <dbReference type="Ensembl" id="ENSMICT00000066639.1">
        <property type="protein sequence ID" value="ENSMICP00000045737.1"/>
        <property type="gene ID" value="ENSMICG00000048019.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF5">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9877" checksum="2A07BDABEACB896F" modified="2022-01-19" version="1">MYSRKAAEEVKQELIKLKVNYYILEESWCIRRSKPGCSMPEIWDVEDPANAGKTPLCNLLVKESKPHFTTVFQNSVYKVLEVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4K2</accession>
    <name>A0A8C5Y4K2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 345</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF345</name>
        <name evidence="14" type="synonym">ZFP30</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026964">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4K2"/>
    <dbReference type="Ensembl" id="ENSMICT00000062499.1">
        <property type="protein sequence ID" value="ENSMICP00000045407.1"/>
        <property type="gene ID" value="ENSMICG00000043350.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163308"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002894">
        <property type="entry name" value="AGAP010979-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000800">
        <property type="entry name" value="zinc finger protein 181 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000058">
        <property type="entry name" value="Zinc finger protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002259">
        <property type="entry name" value="zinc finger protein 271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF8">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="322"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="346" mass="39288" checksum="B1CF9670925D63BF" modified="2022-01-19" version="1">METLTKHSIEYSSFRGDWECKSQFERKQGSQEGHFSEMIFTPEDIPTFSTRFVSVLIRHQRIHTGEKPYECKECGKAFGSGANLAYHQRIHTGEKPYECKECGKAFGSGSNLTHHQRIHTGEKPYECKESCGMAFSSGSALTRHQRIHTGEKPYICNECGKAFSFGSALTRHQRIHTGEKPYICKECGKAFNSRSDLTQHQRIHTGEKPYECTECEKAFRSGSKLIQHQRMHTGEKPYQCKECGKAFGSGSDLTQHWRIHTGEKPYECKECGKAFSSGSKLNQHQLIHTGEKLYECKECGKSFSSNSAVNRHQRIHTGEKPYECKECGKAFRSGSSLTQHQRIHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4T8</accession>
    <name>A0A8C5Y4T8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TLE family member 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TLE7</name>
        <name evidence="3" type="synonym">LOC105859051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat Groucho/TLE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4T8"/>
    <dbReference type="Ensembl" id="ENSMICT00000061156.1">
        <property type="protein sequence ID" value="ENSMICP00000045812.1"/>
        <property type="gene ID" value="ENSMICG00000046469.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234519"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009146">
        <property type="entry name" value="Groucho_enhance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10814:SF33">
        <property type="entry name" value="TRANSDUCIN-LIKE ENHANCER PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="442" mass="49865" checksum="446F90BC10AF0ED3" modified="2022-01-19" version="1">MSKAKKKNSFGMPRVHDEPEERRNVPESSGISNQHGQQGQQQSDHLHRMSREPLDCPTQHQPVYQELTAVTQQQWNRRALGLSELQATYSSKVEVGDEAVAGPSHLPPGHEYGWPHLCPPSAEVYSLLSKIPLVPDNVVVTRRAPWTTWKVGTLGHGKRVFAVAISRSTHHVYTCGTGCIKVWDKSALHATDSAPQAQLDLQDPNDSVFTCKLFPDEQSLITGGLSQRQTLTVWDLAPTPRVRVHLPTANSMCPSLALSHDARLCFACFKGCVEIWDVHNQILVRKHDIPKSGSRRIEVAGNKFWTGGEDTILYSWDLRTYRMLRQCCLHYEILSITHDPSEEWVLAGLRTGSIFILHTHRDDWFKTVAQKYYHHHNIKFASSGSFFVATTDTSINFFQAASLQKSFEVVEPFEILCCDMSPDNQYLITGSKNSATTYQLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4U0</accession>
    <name>A0A8C5Y4U0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine rich secretory protein LCCL domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRISPLD2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023429">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023430">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620092.2">
        <property type="nucleotide sequence ID" value="XM_012764638.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4U0"/>
    <dbReference type="Ensembl" id="ENSMICT00000002255.3">
        <property type="protein sequence ID" value="ENSMICP00000002063.2"/>
        <property type="gene ID" value="ENSMICG00000002251.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061735.1">
        <property type="protein sequence ID" value="ENSMICP00000045514.1"/>
        <property type="gene ID" value="ENSMICG00000002251.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105871345"/>
    <dbReference type="CTD" id="83716"/>
    <dbReference type="GeneTree" id="ENSGT00940000157410"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060325">
        <property type="term" value="P:face morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000001">
        <property type="entry name" value="Cysteine-rich secretory protein LCCL domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.130.20:FF:000001">
        <property type="entry name" value="Cysteine-rich secretory protein LCCL domain-containing 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044680990" evidence="7">
        <location>
            <begin position="23"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="8">
        <location>
            <begin position="284"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="8">
        <location>
            <begin position="385"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="497" mass="55737" checksum="52F0EF1A8282985F" modified="2022-01-19" version="1">MSRVLGCAVPLGLVLLVCGAQGYFLPNVTRLGELLGRYQRAEPHSRARRAIPREDREEILMLHNKLRGQVHPPAANMEYMTWDEELERSAAAWAQECVWEHGPARLLVSIGQNLAVHWGRYRSPGFHVQSWYDEVKDYTYPYPHECNPWCPERCSGAMCTHYTQIVWATTNKVGCAVNTCPRMNVWGEVWENAVYLVCNYSPKGNWIGEAPYKNGRPCSQCPPSYGGGCRNNLCYREETYHQKPETDEMNEVEVSPVPEEKHVWVQPRVSRPAKPKKAPAVSYMTQVVRCDTKMKDKCKGSTCNRYQCPAGCLRNKAKIFGTLFYESSSSICRAAIHHGVLDDQGGLVDVTRNGKVPFFVRSERNGLESLSKYKPSGSFTVSKVKVQDLDCYTTVAQLCPFEKPAVHCPRVRCPAHCKDEPSYWAPVFGTNIYADTSSICKSALHAGVIGDGSGGYVDVMPVDKKKSYAGSLRNGVQSESLDSPRDGKAFRIFAVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y9M5</accession>
    <name>A0A8C5Y9M5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CARD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC105867185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y9M5"/>
    <dbReference type="Ensembl" id="ENSMICT00000059389.1">
        <property type="protein sequence ID" value="ENSMICP00000048438.1"/>
        <property type="gene ID" value="ENSMICG00000044374.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157710"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.10:FF:000014">
        <property type="entry name" value="Apoptotic protease-activating factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22845:SF5">
        <property type="entry name" value="APOPTOTIC PROTEASE-ACTIVATING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00619">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="113" mass="12742" checksum="152189AD09BC9B9A" modified="2022-01-19" version="1">MDAKSRNCLLQHKAALEKDIKTPYIMDHMVGDGVLTTLEEEEVRNESTQQKRAALLIKMILKKDNYCYISFYNALLHEGYKDLAALLQDGIPVVSSSSDKDSVGRITTYGLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YE52</accession>
    <name>A0A8C5YE52_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">N-acetylglucosamine-1-phosphotransferase subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GlcNAc-1-phosphotransferase subunit gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GNPTG</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic subunit of the N-acetylglucosamine-1-phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer; disulfide-linked. Hexamer of two alpha (GNPTAB), two beta (GNPTAB) and two gamma (GNPTG) subunits; disulfide-linked. The alpha and/or the beta subunits of the enzyme constitute the catalytic subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020776">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598974.1">
        <property type="nucleotide sequence ID" value="XM_012743520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YE52"/>
    <dbReference type="Ensembl" id="ENSMICT00000071064.1">
        <property type="protein sequence ID" value="ENSMICP00000050341.1"/>
        <property type="gene ID" value="ENSMICG00000047931.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105859600"/>
    <dbReference type="CTD" id="84572"/>
    <dbReference type="GeneTree" id="ENSGT00510000048359"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070622">
        <property type="term" value="C:UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000018">
        <property type="entry name" value="N-acetylglucosamine-1-phosphotransferase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF6">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150545" description="N-acetylglucosamine-1-phosphotransferase subunit gamma" evidence="14">
        <location>
            <begin position="23"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="16">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="DMAP1-binding" evidence="15">
        <location>
            <begin position="174"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="267"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00083545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="304" mass="33812" checksum="3133EDA5DB9427F5" modified="2022-01-19" version="1">MAAKAAYVLLLLGLAARGPAGAAKMKVVEEPNTFGMNNLFVPQSSRLQPRREPAPVSGPEHLFRLAGKCFSLVESMYKYEFCPFHNVTQHEQTFRWNAYSGILGIWQEWEITNNTFAGMWMKDGDSCRSRSRQSKVELTCGKSNRLAHVSEPSTCVYSLTFETPLVCHPHSLLVYPALPEALQQRWDQVEQDLADELITPQGYEKLLRAIFEDAGYLMTPGENGPVLQEGAPAGLGFETLETCRKAHAELSKEVKRLRSLLAQHGIRHAKPTGTSSSEHLAHDTPTDRPPVQPRGDPGLRGSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEE8</accession>
    <name>A0A8C5YEE8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 50A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM50A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001835">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001836">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001837">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606191.1">
        <property type="nucleotide sequence ID" value="XM_012750737.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606192.1">
        <property type="nucleotide sequence ID" value="XM_012750738.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606193.1">
        <property type="nucleotide sequence ID" value="XM_012750739.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEE8"/>
    <dbReference type="Ensembl" id="ENSMICT00000016219.3">
        <property type="protein sequence ID" value="ENSMICP00000014782.2"/>
        <property type="gene ID" value="ENSMICG00000016225.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000059723.1">
        <property type="protein sequence ID" value="ENSMICP00000049855.1"/>
        <property type="gene ID" value="ENSMICG00000016225.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863532"/>
    <dbReference type="KEGG" id="mmur:105863532"/>
    <dbReference type="CTD" id="23585"/>
    <dbReference type="GeneTree" id="ENSGT00940000157715"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="157" mass="17357" checksum="96FB2AB84339AF92" modified="2022-01-19" version="1">MSGFLEGLRCSECVDWGEKRNTIASIAAGVLFFTGWWIIIDAAVIYPTMEDFNHSYHACGVIATIAFLMINAVSNGQVRGDSYSEGCLGQTGARIWLFIGFMLAFGSLIASMWILFGGYVAKEKAIVYPGIAVFFQNAFIFFGGLVFKFGRTEDLWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJK6</accession>
    <name>A0A8C6EJK6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C-X-C chemokine receptor type 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Interferon-inducible protein 10 receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CXCR3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033685">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591636.1">
        <property type="nucleotide sequence ID" value="XM_012736182.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJK6"/>
    <dbReference type="Ensembl" id="ENSMICT00000062800.1">
        <property type="protein sequence ID" value="ENSMICP00000047234.1"/>
        <property type="gene ID" value="ENSMICG00000038479.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105855307"/>
    <dbReference type="CTD" id="2833"/>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="OrthoDB" id="9818824at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016494">
        <property type="term" value="F:C-X-C chemokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002685">
        <property type="term" value="P:regulation of leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15180">
        <property type="entry name" value="7tmA_CXCR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000159">
        <property type="entry name" value="C-X-C chemokine receptor type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004070">
        <property type="entry name" value="Chemokine_CXCR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489:SF671">
        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01532">
        <property type="entry name" value="CXCCHMKINER3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0765">Sulfation</keyword>
    <keyword evidence="14 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="7 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="70"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="368" mass="40648" checksum="9785DE650EC4CCA1" modified="2022-01-19" version="1">MVPEMSDHQVLDVSEIASFLENFSSSYDYGENDSDSCCASPPCPQDFSLNFDRAFLPALYGLLFVLGLVGNGAVVAVLLSRRAALSSTDTFLLHLAAADALLVLTLPLWAVDTAVQWVFGAGLCKVAGALFNINFYAGVLLLACISFDRYLSIVHATQLYRRGPRARVALTCMAVWGLCLLFALPDFIFLSARYDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYARILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGLESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWTLLWRLGCPDQRGGQRQPASSRRDSSWSETTEASYSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EK18</accession>
    <name>A0A8C6EK18_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane protein 132D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMEM132D</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM132 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03025135">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025136">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025137">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025138">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025139">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025140">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025143">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EK18"/>
    <dbReference type="Ensembl" id="ENSMICT00000066250.1">
        <property type="protein sequence ID" value="ENSMICP00000047559.1"/>
        <property type="gene ID" value="ENSMICG00000043934.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158942"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031437">
        <property type="entry name" value="Ig_TMEM132_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055423">
        <property type="entry name" value="Ig_TMEM132_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055424">
        <property type="entry name" value="Ig_TMEM132_6th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026307">
        <property type="entry name" value="TMEM132"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055421">
        <property type="entry name" value="TMEM132_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031436">
        <property type="entry name" value="TMEM132_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13388:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 132D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16070">
        <property type="entry name" value="Ig_TMEM132_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23486">
        <property type="entry name" value="Ig_TMEM132_5th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23487">
        <property type="entry name" value="Ig_TMEM132_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23039">
        <property type="entry name" value="TMEM132_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15706">
        <property type="entry name" value="TMEM132_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 cohesin-like" evidence="10">
        <location>
            <begin position="158"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein family 132 fourth" evidence="9">
        <location>
            <begin position="214"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 fifth" evidence="11">
        <location>
            <begin position="314"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 sixth" evidence="12">
        <location>
            <begin position="451"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 C-terminal" evidence="8">
        <location>
            <begin position="675"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="585"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="807"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="889" mass="96078" checksum="C039FAF1773E8F48" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EL93</accession>
    <name>A0A8C6EL93_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Centrosomal protein of 97 kDa</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucine-rich repeat and IQ domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CEP97</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001247">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001248">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635126.1">
        <property type="nucleotide sequence ID" value="XM_012779672.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EL93"/>
    <dbReference type="Ensembl" id="ENSMICT00000072293.1">
        <property type="protein sequence ID" value="ENSMICP00000050775.1"/>
        <property type="gene ID" value="ENSMICG00000049248.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879440"/>
    <dbReference type="KEGG" id="mmur:105879440"/>
    <dbReference type="CTD" id="79598"/>
    <dbReference type="GeneTree" id="ENSGT00910000144283"/>
    <dbReference type="OrthoDB" id="5954088at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000165">
        <property type="entry name" value="Centrosomal protein of 97 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000199">
        <property type="entry name" value="centrosomal protein of 97 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF2">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 97 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="584"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="859" mass="96338" checksum="3570C9C6D739553D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q2QL90</accession>
    <name>CAV1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName>Caveolin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">CAV1</name>
    </gene>
    <organism>
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-11" db="EMBL/GenBank/DDBJ databases">
            <title>NISC comparative sequencing initiative.</title>
            <authorList>
                <person name="Antonellis A."/>
                <person name="Ayele K."/>
                <person name="Benjamin B."/>
                <person name="Blakesley R.W."/>
                <person name="Boakye A."/>
                <person name="Bouffard G.G."/>
                <person name="Brinkley C."/>
                <person name="Brooks S."/>
                <person name="Chu G."/>
                <person name="Coleman H."/>
                <person name="Engle J."/>
                <person name="Gestole M."/>
                <person name="Greene A."/>
                <person name="Guan X."/>
                <person name="Gupta J."/>
                <person name="Haghighi P."/>
                <person name="Han J."/>
                <person name="Hansen N."/>
                <person name="Ho S.-L."/>
                <person name="Hu P."/>
                <person name="Hunter G."/>
                <person name="Hurle B."/>
                <person name="Idol J.R."/>
                <person name="Kwong P."/>
                <person name="Laric P."/>
                <person name="Larson S."/>
                <person name="Lee-Lin S.-Q."/>
                <person name="Legaspi R."/>
                <person name="Madden M."/>
                <person name="Maduro Q.L."/>
                <person name="Maduro V.B."/>
                <person name="Margulies E.H."/>
                <person name="Masiello C."/>
                <person name="Maskeri B."/>
                <person name="McDowell J."/>
                <person name="Mojidi H.A."/>
                <person name="Mullikin J.C."/>
                <person name="Oestreicher J.S."/>
                <person name="Park M."/>
                <person name="Portnoy M.E."/>
                <person name="Prasad A."/>
                <person name="Puri O."/>
                <person name="Reddix-Dugue N."/>
                <person name="Schandler K."/>
                <person name="Schueler M.G."/>
                <person name="Sison C."/>
                <person name="Stantripop S."/>
                <person name="Stephen E."/>
                <person name="Taye A."/>
                <person name="Thomas J.W."/>
                <person name="Thomas P.J."/>
                <person name="Tsipouri V."/>
                <person name="Ung L."/>
                <person name="Vogt J.L."/>
                <person name="Wetherby K.D."/>
                <person name="Young A."/>
                <person name="Green E.D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3 4">May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3 4 5">Homooligomer. Interacts with GLIPR2. Interacts with NOSTRIN (By similarity). Interacts with SNAP25 and STX1A (By similarity). Interacts (via the N-terminus) with DPP4; the interaction is direct (By similarity). Interacts with CTNNB1, CDH1 and JUP. Interacts with PACSIN2; this interaction induces membrane tubulation (By similarity). Interacts with SLC7A9 (By similarity). Interacts with BMX and BTK. Interacts with TGFBR1. Interacts with CAVIN3 (via leucine-zipper domain) in a cholesterol-sensitive manner. Interacts with CAVIN1. Interacts with EHD2 in a cholesterol-dependent manner. Forms a ternary complex with UBXN6 and VCP; mediates CAV1 targeting to lysosomes for degradation. Interacts with ABCG1; this interaction regulates ABCG1-mediated cholesterol efflux (By similarity). Interacts with NEU3; this interaction enhances NEU3 sialidase activity within caveola. Interacts (via C-terminus) with SPRY1, SPRY2 (via C-terminus), SPRY3, and SPRY4 (By similarity). Interacts with IGFBP5; this interaction allows trafficking of IGFBP5 from the plasma membrane to the nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Caveola</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1 4">Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). In the presence of DSG2 localizes to the cytoplasm away from cell borders (By similarity).</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Ubiquitinated. Undergo monoubiquitination and multi- and/or polyubiquitination. Monoubiquitination of N-terminal lysines promotes integration in a ternary complex with UBXN6 and VCP which promotes oligomeric CAV1 targeting to lysosomes for degradation. Ubiquitinated by ZNRF1; leading to degradation and modulation of the TLR4-mediated immune response.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="EMBL" id="DP000022">
        <property type="protein sequence ID" value="ABB89819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616553.1">
        <property type="nucleotide sequence ID" value="XM_012761099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q2QL90"/>
    <dbReference type="SMR" id="Q2QL90"/>
    <dbReference type="Ensembl" id="ENSMICT00000050192.2">
        <property type="protein sequence ID" value="ENSMICP00000031777.1"/>
        <property type="gene ID" value="ENSMICG00000026847.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869367"/>
    <dbReference type="KEGG" id="mmur:105869367"/>
    <dbReference type="CTD" id="857"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMICG00000026847">
        <property type="expression patterns" value="Expressed in lung and 7 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002080">
        <property type="term" value="C:acrosomal membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002095">
        <property type="term" value="C:caveolar macromolecular signaling complex"/>
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        <property type="term" value="C:cell cortex"/>
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        <property type="term" value="C:cilium"/>
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        <property type="term" value="C:endoplasmic reticulum"/>
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        <property type="term" value="C:endosome"/>
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        <property type="term" value="C:focal adhesion"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="term" value="F:inward rectifier potassium channel inhibitor activity"/>
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        <property type="term" value="F:oxysterol binding"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="term" value="F:small GTPase binding"/>
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    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
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    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0038166">
        <property type="term" value="P:angiotensin-activated signaling pathway"/>
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    </dbReference>
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        <property type="term" value="P:apoptotic signaling pathway"/>
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        <property type="term" value="P:basement membrane organization"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
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    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
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    <dbReference type="GO" id="GO:0072584">
        <property type="term" value="P:caveolin-mediated endocytosis"/>
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        <property type="term" value="P:cellular response to hyperoxia"/>
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        <property type="term" value="P:cellular response to misfolded protein"/>
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        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
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        <property type="term" value="P:insulin receptor internalization"/>
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        <property type="term" value="P:lactation"/>
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        <property type="term" value="P:lipid storage"/>
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        <property type="term" value="P:mammary gland involution"/>
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        <property type="term" value="P:response to calcium ion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043627">
        <property type="term" value="P:response to estrogen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002931">
        <property type="term" value="P:response to ischemia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032570">
        <property type="term" value="P:response to progesterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001570">
        <property type="term" value="P:vasculogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042310">
        <property type="term" value="P:vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018361">
        <property type="entry name" value="Caveolin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF18">
        <property type="entry name" value="CAVEOLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01210">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0007">Acetylation</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0333">Golgi apparatus</keyword>
    <keyword id="KW-1017">Isopeptide bond</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0832">Ubl conjugation</keyword>
    <feature type="initiator methionine" description="Removed" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000226333" description="Caveolin-1">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="6">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for homooligomerization" evidence="4">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with CAVIN3" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interacts with SPRY1, SPRY2, SPRY3 and SPRY4" evidence="3">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interacts with SPRY1, SPRY2, and SPRY4" evidence="3">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interacts with SPRY1, SPRY2, SPRY3 and SPRY4" evidence="3">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylserine" evidence="4">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; alternate" evidence="4">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="4">
        <location>
            <position position="6"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="3">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by ABL1" evidence="3">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="1">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-palmitoyl cysteine" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate" evidence="4">
        <location>
            <position position="5"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="4">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="4">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="4">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="4">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P41350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P49817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="4">
        <source>
            <dbReference type="UniProtKB" id="Q03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="5">
        <source>
            <dbReference type="UniProtKB" id="Q2IBA5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6"/>
    <evidence type="ECO:0000305" key="7"/>
    <sequence length="179" mass="20666" checksum="0CA4983C20EEB176" modified="2006-01-24" version="1">MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADEVSEKQQVYDAHTKEIDLVNRDPKHLNDDVVKIDFEDVIAEPEGTHSFDGIWKASFTTFTVTKYWFYRLLSALFGIPMALIWGIYFAILSFLHIWAVVPCIKSFLIEIQCISRVYSIYVHTFCDPLFEAIGKVFSNIRINMQKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EBE6</accession>
    <name>A0A8B7EBE6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Vacuolar ATPase assembly factor VMA21</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">VMA21</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="9">Liver</tissue>
        </source>
    </reference>
    <reference evidence="7" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with the V0 complex of the vacuolar ATPase (V-ATPase).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591377.1">
        <property type="nucleotide sequence ID" value="XM_012735923.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EBE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000028830.2">
        <property type="protein sequence ID" value="ENSMICP00000019762.2"/>
        <property type="gene ID" value="ENSMICG00000030051.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105855145"/>
    <dbReference type="KEGG" id="mmur:105855145"/>
    <dbReference type="CTD" id="203547"/>
    <dbReference type="GeneTree" id="ENSGT00390000017980"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019762.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012591377.1"/>
        </source>
    </evidence>
    <sequence length="101" mass="11430" checksum="54047E2AA786B90B" modified="2022-01-19" version="1">MERLDKAALNLMQPPEFRNESSLASTLKTLLFFTALMITVPIGLYFTTKSYIFEGALGMSNRDSYFYAAIVAVVAVHVVLALFVYVAWNEGSRQWREGKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDA4</accession>
    <name>A0A8B7EDA4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Neural cell adhesion molecule 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NCAM2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
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                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
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                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
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                <person name="Puazo M."/>
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                <person name="Raj R."/>
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                <person name="Xin Y."/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
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                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
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                <person name="Durand N."/>
                <person name="Shamim M."/>
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                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
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            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC39 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592440.1">
        <property type="nucleotide sequence ID" value="XM_012736986.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EE27"/>
    <dbReference type="Ensembl" id="ENSMICT00000071284.2">
        <property type="protein sequence ID" value="ENSMICP00000051237.1"/>
        <property type="gene ID" value="ENSMICG00000048849.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105855807"/>
    <dbReference type="KEGG" id="mmur:105855807"/>
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    <dbReference type="GeneTree" id="ENSGT00390000015010"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="GOC"/>
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        <property type="term" value="P:central nervous system myelination"/>
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    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090660">
        <property type="term" value="P:cerebrospinal fluid circulation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0071907">
        <property type="term" value="P:determination of digestive tract left/right asymmetry"/>
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    <dbReference type="GO" id="GO:0071910">
        <property type="term" value="P:determination of liver left/right asymmetry"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035469">
        <property type="term" value="P:determination of pancreatic left/right asymmetry"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:establishment of left/right asymmetry"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040011">
        <property type="term" value="P:locomotion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014004">
        <property type="term" value="P:microglia differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044458">
        <property type="term" value="P:motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150076">
        <property type="term" value="P:neuroinflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cilium beat frequency"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060074">
        <property type="term" value="P:synapse maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033290">
        <property type="entry name" value="CCDC39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18962:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24161">
        <property type="entry name" value="CCDC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="867"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="164"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="458"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="540"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="664"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="733"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="880"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="928"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="939" mass="109840" checksum="515C52FD6F97BE36" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQ86</accession>
    <name>A0A8B7EQ86_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Centromere protein M</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Proliferation-associated nuclear element protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CENPM</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597224.1">
        <property type="nucleotide sequence ID" value="XM_012741770.3"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000031249.2">
        <property type="protein sequence ID" value="ENSMICP00000018419.1"/>
        <property type="gene ID" value="ENSMICG00000032243.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858551"/>
    <dbReference type="KEGG" id="mmur:105858551"/>
    <dbReference type="CTD" id="79019"/>
    <dbReference type="GeneTree" id="ENSGT00390000017504"/>
    <dbReference type="OrthoDB" id="2386686at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001481">
        <property type="entry name" value="Centromere protein M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020987">
        <property type="entry name" value="Centromere_Cenp-M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34436">
        <property type="entry name" value="CENTROMERE PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34436:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11111">
        <property type="entry name" value="CENP-M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062961"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077589"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="180" mass="19877" checksum="2799FC582F0C6F93" modified="2022-01-19" version="1">MSVLRPLDKLPGLNTATILLVGAEDALLQLLADSMLKEDCVSQLKVHLARSLPLPANVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDSSFFLGKVCFLATGAGQENHCIIHRHTVVKLAHTYQSPLLFCDLEVEGFRATMAQRLVRMLQICAGHMPGVSALNLLSLLRSSESPSLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ESF2</accession>
    <name>A0A8B7ESF2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule associated tyrosine carboxypeptidase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MATCAP1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ABDC03024310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598061.1">
        <property type="nucleotide sequence ID" value="XM_012742607.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598063.1">
        <property type="nucleotide sequence ID" value="XM_012742609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598064.1">
        <property type="nucleotide sequence ID" value="XM_012742610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ESF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000049245.2">
        <property type="protein sequence ID" value="ENSMICP00000036972.1"/>
        <property type="gene ID" value="ENSMICG00000035308.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105859042"/>
    <dbReference type="KEGG" id="mmur:105859042"/>
    <dbReference type="CTD" id="653319"/>
    <dbReference type="GeneTree" id="ENSGT00390000004417"/>
    <dbReference type="OrthoDB" id="449345at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106423">
        <property type="term" value="F:tubulin-tyrosine carboxypeptidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012548">
        <property type="entry name" value="MATCAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31817:SF1">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED TYROSINE CARBOXYPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08014">
        <property type="entry name" value="MATCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01154">
        <property type="entry name" value="DUF1704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="471" mass="53565" checksum="D1E0E0659799BB8A" modified="2022-01-19" version="1">MVLDSGDQVYERAPPSPSASPPSLHHRLKPSDRDGLPRYPWSQSLALPLALAVPSVLQPQPERQLSSKLHLGPRSHMRRSESTYTVNITSQRGCGTQGRATPGRGRNPSGGNLRSASSLPHIAKTRRDAGHGASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPRPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEATTGGQLLTKCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNAQQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLARYVQDADVRWEYCVRAKRGQTDTSKPGCFSKDQVYLDGIVHILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMHDLTRYRQQLEHIMATNRLDEAELGRLLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ETH5</accession>
    <name>A0A8B7ETH5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NOXRED1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Probable oxidoreductase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003912">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598470.1">
        <property type="nucleotide sequence ID" value="XM_012743016.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020141278.1">
        <property type="nucleotide sequence ID" value="XM_020285689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ETH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000017169.3">
        <property type="protein sequence ID" value="ENSMICP00000015639.3"/>
        <property type="gene ID" value="ENSMICG00000017170.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859304"/>
    <dbReference type="KEGG" id="mmur:105859304"/>
    <dbReference type="CTD" id="122945"/>
    <dbReference type="GeneTree" id="ENSGT00950000183044"/>
    <dbReference type="OrthoDB" id="195672at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000447">
        <property type="entry name" value="NADP dependent oxidoreductase domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF58">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="5">
        <location>
            <begin position="80"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015639.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="361" mass="40589" checksum="BE2A57582B6716E3" modified="2022-01-19" version="1">MDLLEDLASLQFDCGISEEESFLLYLQGRYRGLMINACAHATFFCKLLCNLRKLLHEKQSSRYRSVGSLHLTTPDNNKLKVGIIGGGHLGKQLALTLLQLVPIPAESLRISTRRPEALEEFQKLGIQCFYHNSNLASWANVIFLCCLPSQLSHICLEIQTSLEKTCVVYSFVAAVPLPRLKLLLNHTNILRPQYECVEDYVNIWGANKEVAAALQDPVILEATCPYIPAGGITLNMKWLEGVCYAALNMCTARKLANPQALLLLNELFLSVHFKYCKKNTASCPKFQPTDFVNKIYVKSLSRNRSFPWFDLTIAQLKKTPFSQCLSTSTVLQRHLTYLYCDLFGISLTKEQPVVSTGSLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2V3</accession>
    <name>A0A8B7F2V3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">THO complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Nuclear matrix protein p84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">THOC1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
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        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the THOC1 family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <feature type="region of interest" description="Disordered" evidence="22">
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="14">Glucocorticoid modulatory element binding protein 1</fullName>
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        <name evidence="14" type="primary">GMEB1</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
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    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Also binds to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:Hsp27 protein binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="PANTHER" id="PTHR10417">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10417:SF3">
        <property type="entry name" value="GLUCOCORTICOID MODULATORY ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25892">
        <property type="entry name" value="Spe-44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SAND" evidence="13">
        <location>
            <begin position="82"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="370"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="332"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049777.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="573" mass="62576" checksum="29079A1E5535C02A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FF63</accession>
    <name>A0A8B7FF63_MICMU</name>
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        <recommendedName>
            <fullName evidence="11">Growth/differentiation factor 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Bone morphogenetic protein 3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GDF10</name>
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    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TGF-beta family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012606970.1">
        <property type="nucleotide sequence ID" value="XM_012751516.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FF63"/>
    <dbReference type="Ensembl" id="ENSMICT00000069663.1">
        <property type="protein sequence ID" value="ENSMICP00000047527.1"/>
        <property type="gene ID" value="ENSMICG00000044392.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105863934"/>
    <dbReference type="KEGG" id="mmur:105863934"/>
    <dbReference type="GeneTree" id="ENSGT00940000157214"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030279">
        <property type="term" value="P:negative regulation of ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19394">
        <property type="entry name" value="TGF_beta_GDF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000008">
        <property type="entry name" value="Bone morphogenetic protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017197">
        <property type="entry name" value="BMP3/BMP3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF145">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037403">
        <property type="entry name" value="BMP3/GDF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="9 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0339">Growth factor</keyword>
    <keyword evidence="7" id="KW-0892">Osteogenesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133578" description="Growth/differentiation factor 10" evidence="16">
        <location>
            <begin position="35"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="17">
        <location>
            <begin position="369"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
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            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="272"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="379"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="408"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="412"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="13">
        <location>
            <position position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00042879"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="481" mass="52981" checksum="0E5CD465D0A55831" modified="2022-01-19" version="1">MARGPARTSPGPPGPQLLLLLPPLLLLLLRGAGGSHTAPARAAQSAAAHGLPGDKHPQRPLGDSAATLGPVAQDVVAVHMLRLYEKYSRRGARPGGGNTVRSFRARLEVVNQKAVYFFNLTSLQDSEMILTATFHFYWEPPRWPRAREGLCKLRAKNVSCHLQPSGPPPARRHLLFRSLSWNPAAQGLLRGAVALAPQPHALWQAKDISPIVKAARRDGELLLSAQLDSGEQEAGVPSPGPHVPYILVYANDLAISEPNSVAVTLQRYDPFAAGDPETRAAPNSSADPRVRRAAQVPGPLQDNELPGLDERPARAPHAQHYHEHALWPSPFRALKPRPGRKDRRRKGQDVFLASSQVLHFDKKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKVVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVETCACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FRT2</accession>
    <name>A0A8B7FRT2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane channel-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TMC6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TMC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019837">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611685.1">
        <property type="nucleotide sequence ID" value="XM_012756231.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611686.1">
        <property type="nucleotide sequence ID" value="XM_012756232.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611687.1">
        <property type="nucleotide sequence ID" value="XM_012756233.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611688.1">
        <property type="nucleotide sequence ID" value="XM_012756234.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611689.1">
        <property type="nucleotide sequence ID" value="XM_012756235.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611690.1">
        <property type="nucleotide sequence ID" value="XM_012756236.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136593.1">
        <property type="nucleotide sequence ID" value="XM_020281004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FRT2"/>
    <dbReference type="Ensembl" id="ENSMICT00000039320.2">
        <property type="protein sequence ID" value="ENSMICP00000028527.2"/>
        <property type="gene ID" value="ENSMICG00000003967.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000046817.2">
        <property type="protein sequence ID" value="ENSMICP00000025525.2"/>
        <property type="gene ID" value="ENSMICG00000003967.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866707"/>
    <dbReference type="KEGG" id="mmur:105866707"/>
    <dbReference type="CTD" id="11322"/>
    <dbReference type="GeneTree" id="ENSGT01050000244894"/>
    <dbReference type="OrthoDB" id="1936208at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038900">
        <property type="entry name" value="TMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012496">
        <property type="entry name" value="TMC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302:SF4">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23302">
        <property type="entry name" value="TRANSMEMBRANE CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07810">
        <property type="entry name" value="TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="654"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="726"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="domain" description="TMC" evidence="8">
        <location>
            <begin position="544"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU310713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028527.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="799" mass="88572" checksum="DDDF24E9BB1C8DD2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FVR1</accession>
    <name>A0A8B7FVR1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CAAX prenyl protease 2</fullName>
            <ecNumber evidence="11">3.4.26.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Farnesylated proteins-converting enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RCE1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03006020">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612979.1">
        <property type="nucleotide sequence ID" value="XM_012757525.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FVR1"/>
    <dbReference type="Ensembl" id="ENSMICT00000032489.2">
        <property type="protein sequence ID" value="ENSMICP00000038853.2"/>
        <property type="gene ID" value="ENSMICG00000003857.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867463"/>
    <dbReference type="KEGG" id="mmur:105867463"/>
    <dbReference type="CTD" id="9986"/>
    <dbReference type="GeneTree" id="ENSGT00390000004124"/>
    <dbReference type="OMA" id="HSFCNWC"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008238">
        <property type="term" value="F:exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="14">
        <location>
            <begin position="164"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038853.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="329" mass="35806" checksum="62E7DDE8C2CA8C60" modified="2022-01-19" version="1">MAALGGDGLRLLSVSRPERQPESAALGGPGPGLCCWVSVFSCLSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLADGLKVALAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFLSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQRRPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCVLLERTGDTKAPLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G0U1</accession>
    <name>A0A8B7G0U1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5-oxoprolinase, ATP-hydrolysing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OPLAH</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615532.1">
        <property type="nucleotide sequence ID" value="XM_012760078.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615533.1">
        <property type="nucleotide sequence ID" value="XM_012760079.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000017729.3">
        <property type="protein sequence ID" value="ENSMICP00000016142.2"/>
        <property type="gene ID" value="ENSMICG00000017729.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000058701.1">
        <property type="protein sequence ID" value="ENSMICP00000050369.1"/>
        <property type="gene ID" value="ENSMICG00000017729.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000062313.1">
        <property type="protein sequence ID" value="ENSMICP00000050427.1"/>
        <property type="gene ID" value="ENSMICG00000017729.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868850"/>
    <dbReference type="CTD" id="26873"/>
    <dbReference type="GeneTree" id="ENSGT00390000013463"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="10"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="231"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="546"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="734"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1248"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016142.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1288" mass="138082" checksum="8D9D35EEA9283D01" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G6S9</accession>
    <name>A0A8B7G6S9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Testican-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPOCK2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May participate in diverse steps of neurogenesis. Binds calcium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018951">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618013.1">
        <property type="nucleotide sequence ID" value="XM_012762559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G6S9"/>
    <dbReference type="Ensembl" id="ENSMICT00000004213.3">
        <property type="protein sequence ID" value="ENSMICP00000003840.2"/>
        <property type="gene ID" value="ENSMICG00000004214.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870173"/>
    <dbReference type="KEGG" id="mmur:105870173"/>
    <dbReference type="CTD" id="9806"/>
    <dbReference type="GeneTree" id="ENSGT00940000157107"/>
    <dbReference type="OrthoDB" id="8875634at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000101">
        <property type="entry name" value="SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000003">
        <property type="entry name" value="SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000001">
        <property type="entry name" value="Testican-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019577">
        <property type="entry name" value="SPARC/Testican_Ca-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866">
        <property type="entry name" value="SPARC OSTEONECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13866:SF18">
        <property type="entry name" value="TESTICAN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10591">
        <property type="entry name" value="SPARC_Ca_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0357">Heparan sulfate</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133798" description="Testican-2" evidence="16">
        <location>
            <begin position="23"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="18">
        <location>
            <begin position="130"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="17">
        <location>
            <begin position="308"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="385"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="346"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003840.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="419" mass="46513" checksum="E671D30E8AB37A7A" modified="2022-01-19" version="1">MRAPGCGRLALPLLLLAAAALAEGDAKGHKEGETPGNFMEDEQWLSSISQYSGKIKHWNRFRDEVEDDYIKSWEDNQQGDEALDTTKDPCQKVKCSRHKVCVAQGYQRAMCISRKKLEHRIKQPALKFHGNRDSNCKPCHMAQLASVCGSDGHTYSSVCKLEQQACLSSKQLTVRCEGPCPCPTEQAAAADGKPEACTGQDLADLGDRLRDWFQLLHENSKQNGSASSAASPASGLDKSLVASCKDSIGWMFTKLDTSADLFLDQTELAAINLDKYEVCIRPFFNSCDTYKDGRVSTAEWCFCFWREKPPCLAELERIQIQEAAKKKTGGFIPSCDEDGYYRKMQCDQRSGDCWCVDQLGLELTSTRMRGSPDCDDIVGFSGDFGSGVGWEDEEEKEPEEAGEETEEEEGEADDGGYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8N5</accession>
    <name>A0A8B7G8N5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SOAT2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + cholesterol = cholesteryl (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA</text>
            <dbReference type="Rhea" id="RHEA:42816"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:82751"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:42817"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a sterol + a long-chain fatty acyl-CoA = a long-chain 3-hydroxysterol ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:59816"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:232093"/>
            <dbReference type="EC" id="2.3.1.26"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:59817"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA</text>
            <dbReference type="Rhea" id="RHEA:41436"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:46898"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + cholesterol = a cholesterol ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17729"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17002"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:17730"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Endoplasmic reticulum membrane</location>
            <topology evidence="2 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618785.1">
        <property type="nucleotide sequence ID" value="XM_012763331.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8N5"/>
    <dbReference type="Ensembl" id="ENSMICT00000014166.3">
        <property type="protein sequence ID" value="ENSMICP00000012916.1"/>
        <property type="gene ID" value="ENSMICG00000014163.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870615"/>
    <dbReference type="KEGG" id="mmur:105870615"/>
    <dbReference type="CTD" id="8435"/>
    <dbReference type="GeneTree" id="ENSGT00950000183081"/>
    <dbReference type="OMA" id="TMNDRHT"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034736">
        <property type="term" value="F:cholesterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010878">
        <property type="term" value="P:cholesterol storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045797">
        <property type="term" value="P:positive regulation of intestinal cholesterol absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034379">
        <property type="term" value="P:very-low-density lipoprotein particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030687">
        <property type="entry name" value="Sterol_acyltranf_meta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF10">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500230">
        <property type="entry name" value="Sterol_acyltranf_ACAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="7 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 17 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="525" mass="60046" checksum="CA86E4FFCE9E6E05" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8P9</accession>
    <name>A0A8B7G8P9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">S-adenosylmethionine-dependent nucleotide dehydratase RSAD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Radical S-adenosyl methionine domain-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RSAD2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65944"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:166821"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homodimer. Interacts with IRAK1 and TRAF6. Interacts with FPPS. Interacts with HADHB. Interacts (via C-terminus) with VAPA/VAP33 (via C-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the radical SAM superfamily. RSAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618805.1">
        <property type="nucleotide sequence ID" value="XM_012763351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8P9"/>
    <dbReference type="Ensembl" id="ENSMICT00000043468.2">
        <property type="protein sequence ID" value="ENSMICP00000030911.1"/>
        <property type="gene ID" value="ENSMICG00000000161.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870632"/>
    <dbReference type="KEGG" id="mmur:105870632"/>
    <dbReference type="CTD" id="91543"/>
    <dbReference type="GeneTree" id="ENSGT00390000013670"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043367">
        <property type="term" value="P:CD4-positive, alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045071">
        <property type="term" value="P:negative regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000553">
        <property type="term" value="P:positive regulation of T-helper 2 cell cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034157">
        <property type="term" value="P:positive regulation of toll-like receptor 7 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034165">
        <property type="term" value="P:positive regulation of toll-like receptor 9 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000152">
        <property type="entry name" value="radical S-adenosyl methionine domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026372">
        <property type="entry name" value="RSAD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04278">
        <property type="entry name" value="viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="22">
        <location>
            <begin position="79"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="371" mass="43109" checksum="4826F19A75A41591" modified="2022-01-19" version="1">MWTLVPTTFAGKMLSTFGQPLGSLWRSLVPLLCWLKTVLWLPGTQRSRQQQQQQQQQQQQPRKEPDENREEEKEDILLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLQEAKRGLLLLKEAGMEKINFSGGEPFIQDRGEYVGQLVQFCKQELRLPSVSIVSNGSLIRERWFRNYGEYLDILAISCDSFDEQVNVLIGRGQGKKNHVENLQKLRTWCRDYRVAFKINSVINRFNVDEDMNEQIAALSPVRWKVFQCLLIEGENTGEDALREAGRFVISDEEFEGFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCQNGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLKLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G9A2</accession>
    <name>A0A8B7G9A2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gliomedin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GLDN</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618930.1">
        <property type="nucleotide sequence ID" value="XM_012763476.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G9A2"/>
    <dbReference type="Ensembl" id="ENSMICT00000043170.2">
        <property type="protein sequence ID" value="ENSMICP00000036106.1"/>
        <property type="gene ID" value="ENSMICG00000030199.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105870706"/>
    <dbReference type="KEGG" id="mmur:105870706"/>
    <dbReference type="CTD" id="342035"/>
    <dbReference type="GeneTree" id="ENSGT00940000158020"/>
    <dbReference type="OrthoDB" id="8397025at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086080">
        <property type="term" value="F:protein binding involved in heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045162">
        <property type="term" value="P:clustering of voltage-gated sodium channels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032528">
        <property type="term" value="P:microvillus organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF85">
        <property type="entry name" value="GLIOMEDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="5">
        <location>
            <begin position="296"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="548" mass="58937" checksum="45416F0D0CDD055F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GAZ5</accession>
    <name>A0A8B7GAZ5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nipsnap homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NIPSNAP1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NipSnap family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024638">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024639">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024641">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619318.1">
        <property type="nucleotide sequence ID" value="XM_012763864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GAZ5"/>
    <dbReference type="Ensembl" id="ENSMICT00000063431.1">
        <property type="protein sequence ID" value="ENSMICP00000042968.1"/>
        <property type="gene ID" value="ENSMICG00000042066.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870910"/>
    <dbReference type="KEGG" id="mmur:105870910"/>
    <dbReference type="CTD" id="8508"/>
    <dbReference type="GeneTree" id="ENSGT00950000183018"/>
    <dbReference type="OMA" id="NESSWFR"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097060">
        <property type="term" value="C:synaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000003">
        <property type="entry name" value="Protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000007">
        <property type="entry name" value="protein NipSnap homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF11">
        <property type="entry name" value="PROTEIN NIPSNAP HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIPSNAP" evidence="7">
        <location>
            <begin position="183"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00055688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="282" mass="33191" checksum="6311374AACC2DD82" modified="2022-01-19" version="1">MAPRLCSISAAARRWLGGPGPRARDLAAAARFYSKDNESSWFRSLFVHKVDPRKDAHSTLLSKKETSNLYKIQFHNVKPECLDTYNSLTEAVLPKLHLDEDYPCSLVGNWNTWYGEQDQAVHLWRFSGGYPALMDCMNKLKNNKEYLEFRKERSQMLLSRRNQLLLEFSFWNEPLPRAGPNIYELRTYKLKPGTMIEWGNNWARAIKYRQENQEAVGGFFSQIGELYIVHHLWAYKDLQSREETRNAAWRKRGWDENVYYTVPLVRHMESRIMIPLKISPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GBB6</accession>
    <name>A0A8B7GBB6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myosin light chain 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">MYL11</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619690.1">
        <property type="nucleotide sequence ID" value="XM_012764236.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7GBB6"/>
    <dbReference type="Ensembl" id="ENSMICT00000044575.2">
        <property type="protein sequence ID" value="ENSMICP00000023815.1"/>
        <property type="gene ID" value="ENSMICG00000030453.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871086"/>
    <dbReference type="KEGG" id="mmur:105871086"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159038"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006936">
        <property type="term" value="P:muscle contraction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Myosin regulatory light chain 2, atrial isoform"/>
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        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
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    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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        <property type="entry name" value="Myosin_RLC"/>
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    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
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    </dbReference>
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        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF_HAND_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="170" mass="18937" checksum="08499358775582D4" modified="2022-01-19" version="1">MAPKKAKRRAAAEGGSSNVFSMFDQTQIQEFKEAFTVIDQNRDGIIDKEDLRDTFAAMGRLNVKNEELDAMMKEASGPINFTVFLTMFGEKLKGADPEDVITGAFKVLDPDGKGTIKKQFLEELLTTQCDRFTPAEIKNMWAAFPPDVGGNVDYKNICYVITHGDAKDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GCX9</accession>
    <name>A0A8B7GCX9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tenascin-R</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Janusin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Restrictin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TNR</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tenascin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620504.1">
        <property type="nucleotide sequence ID" value="XM_012765050.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620505.1">
        <property type="nucleotide sequence ID" value="XM_012765051.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620506.1">
        <property type="nucleotide sequence ID" value="XM_012765052.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620507.1">
        <property type="nucleotide sequence ID" value="XM_012765053.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069014.1">
        <property type="protein sequence ID" value="ENSMICP00000044954.1"/>
        <property type="gene ID" value="ENSMICG00000045123.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069193.1">
        <property type="protein sequence ID" value="ENSMICP00000046375.1"/>
        <property type="gene ID" value="ENSMICG00000045123.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105871632"/>
    <dbReference type="KEGG" id="mmur:105871632"/>
    <dbReference type="CTD" id="7143"/>
    <dbReference type="GeneTree" id="ENSGT00940000157761"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072534">
        <property type="term" value="C:perineuronal net"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090733">
        <property type="term" value="C:tenascin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048677">
        <property type="term" value="P:axon extension involved in regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035641">
        <property type="term" value="P:locomotory exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048692">
        <property type="term" value="P:negative regulation of axon extension involved in regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022408">
        <property type="term" value="P:negative regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050805">
        <property type="term" value="P:negative regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097402">
        <property type="term" value="P:neuroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051968">
        <property type="term" value="P:positive regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051971">
        <property type="term" value="P:positive regulation of transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035249">
        <property type="term" value="P:synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022029">
        <property type="term" value="P:telencephalon cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="CDD" id="cd00087">
        <property type="entry name" value="FReD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000099">
        <property type="entry name" value="Fibronectin 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000001">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000201">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000207">
        <property type="entry name" value="Tenascin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.215.10:FF:000001">
        <property type="entry name" value="Tenascin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000609">
        <property type="entry name" value="Tenascin R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000682">
        <property type="entry name" value="Tenascin R"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1550" mass="172785" checksum="F0A58D78D2A377D0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GEP2</accession>
    <name>A0A8B7GEP2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Neuron-specific calcium-binding protein hippocalcin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HPCA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomer; oligomerization is calcium-dependent. May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the recoverin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001618">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620823.1">
        <property type="nucleotide sequence ID" value="XM_012765369.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620826.1">
        <property type="nucleotide sequence ID" value="XM_012765372.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GEP2"/>
    <dbReference type="SMR" id="A0A8B7GEP2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011223.3">
        <property type="protein sequence ID" value="ENSMICP00000010222.1"/>
        <property type="gene ID" value="ENSMICG00000011229.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871795"/>
    <dbReference type="KEGG" id="mmur:105871795"/>
    <dbReference type="CTD" id="3208"/>
    <dbReference type="GeneTree" id="ENSGT00940000158110"/>
    <dbReference type="OMA" id="QMYDPAR"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000078">
        <property type="entry name" value="Hippocalcin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000072">
        <property type="entry name" value="Hippocalcin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF57">
        <property type="entry name" value="NEURON-SPECIFIC CALCIUM-BINDING PROTEIN HIPPOCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0519">Myristate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="193" mass="22427" checksum="3DBEA176AC945DB1" modified="2022-01-19" version="1">MGKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYGDASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISREEMLEIVQAIYKMVSSVMKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDPSIVRLLQCDPSSASQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GEV8</accession>
    <name>A0A8B7GEV8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
            <ecNumber evidence="11">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DUSP1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EC" id="3.1.3.48" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03027333">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620953.1">
        <property type="nucleotide sequence ID" value="XM_012765499.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GEV8"/>
    <dbReference type="Ensembl" id="ENSMICT00000028125.2">
        <property type="protein sequence ID" value="ENSMICP00000030157.1"/>
        <property type="gene ID" value="ENSMICG00000031119.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871862"/>
    <dbReference type="KEGG" id="mmur:105871862"/>
    <dbReference type="CTD" id="1843"/>
    <dbReference type="GeneTree" id="ENSGT00940000159044"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051019">
        <property type="term" value="F:mitogen-activated protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990869">
        <property type="term" value="P:cellular response to chemokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001706">
        <property type="term" value="P:endoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090027">
        <property type="term" value="P:negative regulation of monocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903753">
        <property type="term" value="P:negative regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14638">
        <property type="entry name" value="DSP_DUSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000015">
        <property type="entry name" value="Dual specificity phosphatase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000026">
        <property type="entry name" value="Dual specificity protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF309">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000939">
        <property type="entry name" value="MAPK_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="15">
        <location>
            <begin position="20"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="13">
        <location>
            <begin position="173"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="14">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="12">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="367" mass="39292" checksum="11A2FF54261CD51F" modified="2022-01-19" version="1">MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCAAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHPTNSALSYLQSPITTSPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GLQ4</accession>
    <name>A0A8B7GLQ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Exocyst complex component 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EXOC2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the exocyst complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with EXOC3L1. Interacts with GNEFR/DELGEF; this interaction occurs only in the presence of magnesium or manganese and is stimulated by dCTP or GTP. Interacts with RALA and RALB. Interacts with ARL13B; regulates ARL13B localization to the cilium membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Midbody</location>
            <location evidence="2">Midbody ring</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018416">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623943.1">
        <property type="nucleotide sequence ID" value="XM_012768489.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623944.1">
        <property type="nucleotide sequence ID" value="XM_012768490.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623945.1">
        <property type="nucleotide sequence ID" value="XM_012768491.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GLQ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000062129.1">
        <property type="protein sequence ID" value="ENSMICP00000045840.1"/>
        <property type="gene ID" value="ENSMICG00000007997.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873509"/>
    <dbReference type="KEGG" id="mmur:105873509"/>
    <dbReference type="CTD" id="55770"/>
    <dbReference type="GeneTree" id="ENSGT00390000010872"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000535">
        <property type="term" value="P:regulation of entry of bacterium into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000196">
        <property type="entry name" value="Exocyst complex component 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPT/TIG" evidence="10">
        <location>
            <begin position="8"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="11">
        <location>
            <begin position="133"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="925" mass="104438" checksum="3957B6A0901A4F84" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GR86</accession>
    <name>A0A8B7GR86_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PC4 and SFRS1-interacting protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lens epithelium-derived growth factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSIP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HDGF family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625124.1">
        <property type="nucleotide sequence ID" value="XM_012769670.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625125.1">
        <property type="nucleotide sequence ID" value="XM_012769671.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GR86"/>
    <dbReference type="Ensembl" id="ENSMICT00000042069.2">
        <property type="protein sequence ID" value="ENSMICP00000037176.1"/>
        <property type="gene ID" value="ENSMICG00000013923.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874113"/>
    <dbReference type="KEGG" id="mmur:105874113"/>
    <dbReference type="CTD" id="11168"/>
    <dbReference type="GeneTree" id="ENSGT00940000154706"/>
    <dbReference type="OrthoDB" id="62853at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20151">
        <property type="entry name" value="PWWP_PSIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000017">
        <property type="entry name" value="hepatoma-derived growth factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000005">
        <property type="entry name" value="PC4 and SFRS1-interacting protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036218">
        <property type="entry name" value="HIVI-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021567">
        <property type="entry name" value="LEDGF_IBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550">
        <property type="entry name" value="HEPATOMA-DERIVED GROWTH FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12550:SF42">
        <property type="entry name" value="PC4 AND SFRS1-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11467">
        <property type="entry name" value="LEDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01503">
        <property type="entry name" value="TREACLE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140576">
        <property type="entry name" value="HIV integrase-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PWWP" evidence="11">
        <location>
            <begin position="7"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="213"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="498"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="530" mass="60210" checksum="A85B00EBA28C8CEB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GU42</accession>
    <name>A0A8B7GU42_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease LACTB2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Beta-lactamase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LACTB2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626240.1">
        <property type="nucleotide sequence ID" value="XM_012770786.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144469.1">
        <property type="nucleotide sequence ID" value="XM_020288880.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GU42"/>
    <dbReference type="Ensembl" id="ENSMICT00000058614.1">
        <property type="protein sequence ID" value="ENSMICP00000050491.1"/>
        <property type="gene ID" value="ENSMICG00000048059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105874692"/>
    <dbReference type="KEGG" id="mmur:105874692"/>
    <dbReference type="CTD" id="51110"/>
    <dbReference type="GeneTree" id="ENSGT00390000001710"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07722">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000328">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000017">
        <property type="entry name" value="Lactamase beta 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047921">
        <property type="entry name" value="LACTB2-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041516">
        <property type="entry name" value="LACTB2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050662">
        <property type="entry name" value="Sec-metab_biosynth-thioest"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23131:SF0">
        <property type="entry name" value="ENDORIBONUCLEASE LACTB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17778">
        <property type="entry name" value="WHD_BLACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="9">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="288" mass="32905" checksum="EEC9913DE29643CF" modified="2022-01-19" version="1">MAAVLQRVERLSSRVVRVLGCNPGPMTLQGTNTYLVGTGPRRILIDTGEPAIPEYISCLKQALTEFNTAIQEIIVTHWHRDHTGGIEDICKSISNDTTYCIKKLPRNPHREEIIGNGEQQYVYMKDGDIIKTEGATLRVIYTPGHTDDHMAIFLEEENAFFSGDCILGEGTTVFEDLYDYMNSLKKLLKMKADIIYPGHGPVIHNAEAKILQYISHRNIREQQILTVFRENFEKSFTVMELVKIIYKNTPEHLHRAAEHNLSLHLRKLEKDGKIFSNTDPDKKWKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GV70</accession>
    <name>A0A8B7GV70_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 26 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC26A6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626648.1">
        <property type="nucleotide sequence ID" value="XM_012771194.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626649.1">
        <property type="nucleotide sequence ID" value="XM_012771195.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626651.1">
        <property type="nucleotide sequence ID" value="XM_012771197.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626652.1">
        <property type="nucleotide sequence ID" value="XM_012771198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GV70"/>
    <dbReference type="Ensembl" id="ENSMICT00000055223.2">
        <property type="protein sequence ID" value="ENSMICP00000025456.1"/>
        <property type="gene ID" value="ENSMICG00000027204.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105874934"/>
    <dbReference type="CTD" id="65010"/>
    <dbReference type="GeneTree" id="ENSGT01150000286960"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140900">
        <property type="term" value="F:chloride:bicarbonate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015499">
        <property type="term" value="F:formate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019531">
        <property type="term" value="F:oxalate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071332">
        <property type="term" value="P:cellular response to fructose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042045">
        <property type="term" value="P:epithelial fluid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051454">
        <property type="term" value="P:intracellular pH elevation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015797">
        <property type="term" value="P:mannitol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046724">
        <property type="term" value="P:oxalic acid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001150">
        <property type="term" value="P:positive regulation of dipeptide transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030321">
        <property type="term" value="P:transepithelial chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="9">
        <location>
            <begin position="507"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="628"/>
        </location>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="736" mass="80133" checksum="80D3A88F388BF68E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GZD9</accession>
    <name>A0A8B7GZD9_MICMU</name>
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        <recommendedName>
            <fullName evidence="20">Sodium channel regulatory subunit beta-2</fullName>
        </recommendedName>
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        <name evidence="25" type="primary">SCN2B</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">A voltage-gated sodium (Nav) channel consists of an ion-conducting pore-forming alpha subunit functional on its own that is regulated by one or more beta subunits. The beta subunit SCN2B is disulfide-linked to the pore-forming alpha subunit. Interacts with SCN1A; regulatory subunit of SCN1A/Nav1.1. Interacts with SCN2A; regulatory subunit of SCN2A/Nav1.2. Interacts with SCN3A; regulatory subunit of SCN3A/Nav1.3. Interacts with SCN5A; regulatory subunit of SCN5A/Nav1.5. Interacts with SCN8A; regulatory subunit of SCN8A/Nav1.6. Interacts with SCN9A; regulatory subunit of SCN9A/Nav1.7. Interacts with SCN10A; regulatory subunit of SCN10A/Nav1.8. Interacts with TNR; may play a crucial role in clustering and regulation of activity of SCN2B-containing Nav channels at nodes of Ranvier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000040768.1"/>
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        <property type="term" value="F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="14" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 22" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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    </evidence>
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    <sequence length="215" mass="24378" checksum="8FAC2E4FF62D3B86" modified="2022-01-19" version="1">MHRDAWLPRPAFSLTGLSLFFSLVPPGQSMEVTVPTTLHVLNGSDARLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFRDRVEFSGNPSKYDVSVTLRNVQMEDEGIYNCYIMNPPDRHRGHGKIYLQILMEEPPERDSTVAVIVGASVGGFLAVVILVLVVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H284</accession>
    <name>A0A8B7H284_MICMU</name>
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        <submittedName>
            <fullName evidence="15">Zinc finger protein 527</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF527</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630300.1">
        <property type="nucleotide sequence ID" value="XM_012774846.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630302.1">
        <property type="nucleotide sequence ID" value="XM_012774848.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630303.1">
        <property type="nucleotide sequence ID" value="XM_012774849.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630304.1">
        <property type="nucleotide sequence ID" value="XM_012774850.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H284"/>
    <dbReference type="Ensembl" id="ENSMICT00000006889.3">
        <property type="protein sequence ID" value="ENSMICP00000006276.2"/>
        <property type="gene ID" value="ENSMICG00000006892.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876860"/>
    <dbReference type="KEGG" id="mmur:105876860"/>
    <dbReference type="CTD" id="84503"/>
    <dbReference type="GeneTree" id="ENSGT00940000162987"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000101">
        <property type="entry name" value="zinc finger protein 436 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001174">
        <property type="entry name" value="zinc finger protein 527 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001401">
        <property type="entry name" value="zinc finger protein 527 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001487">
        <property type="entry name" value="zinc finger protein 527 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000099">
        <property type="entry name" value="Zinc finger protein 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF412">
        <property type="entry name" value="ZINC FINGER PROTEIN 983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="14"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="385"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="525"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="553"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006276.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="608" mass="70914" checksum="7945711BD00E5511" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H2H5</accession>
    <name>A0A8B7H2H5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POLR2I</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630417.1">
        <property type="nucleotide sequence ID" value="XM_012774963.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630418.1">
        <property type="nucleotide sequence ID" value="XM_012774964.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H2H5"/>
    <dbReference type="SMR" id="A0A8B7H2H5"/>
    <dbReference type="Ensembl" id="ENSMICT00000010237.3">
        <property type="protein sequence ID" value="ENSMICP00000009323.3"/>
        <property type="gene ID" value="ENSMICG00000010241.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876890"/>
    <dbReference type="KEGG" id="mmur:105876890"/>
    <dbReference type="CTD" id="5438"/>
    <dbReference type="GeneTree" id="ENSGT00550000075063"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="GeneTree" id="ENSGT00390000009077"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033369">
        <property type="entry name" value="C19orf12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493">
        <property type="entry name" value="NAZO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31493:SF1">
        <property type="entry name" value="PROTEIN C19ORF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20721">
        <property type="entry name" value="C19orf12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="141" mass="14837" checksum="431FE68744ED2E5C" modified="2022-01-19" version="1">MPVVVEDIMKLLCSVSEQRKMKAAVKHSGKGALVTGAVAFVGGLVGGPPGLAIGGAVGGLLGAWMASGEFQSVPRILMELPAEEQQKLFLEASAIVRNLDWTDAVQLTALVMGSEALQQQLLAMLAAYVTKELRAEVRYGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H610</accession>
    <name>A0A8B7H610_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">AURKAIP1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631872.1">
        <property type="nucleotide sequence ID" value="XM_012776418.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631873.1">
        <property type="nucleotide sequence ID" value="XM_012776419.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H610"/>
    <dbReference type="Ensembl" id="ENSMICT00000014220.3">
        <property type="protein sequence ID" value="ENSMICP00000012965.1"/>
        <property type="gene ID" value="ENSMICG00000014229.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105877648"/>
    <dbReference type="CTD" id="54998"/>
    <dbReference type="GeneTree" id="ENSGT00390000012802"/>
    <dbReference type="OMA" id="GWTTPKI"/>
    <dbReference type="OrthoDB" id="6139741at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23699">
        <property type="entry name" value="At5g63150_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="199" mass="22842" checksum="4B79D0E9563C8BB8" modified="2022-01-19" version="1">MFLARLTSQLVKAVSWAGYSRAWPVSGVLSSHAHSSRYSVQPTGPSRAASLPGKGAQLELEEMLVPRKLSISPLESWLTARYLVPRLDAGAPETVASAQFYECPSSQVGEGPKQEGEEVWDAPHMQCKNVLKIRRRKMNHHKYRKLVKRTRFLRRKIREGRLKRKQIRFERDLRRIWRKAGLKEAPAGWQTPKIYVKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HAW4</accession>
    <name>A0A8B7HAW4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BCAS2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633866.1">
        <property type="nucleotide sequence ID" value="XM_012778412.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HAW4"/>
    <dbReference type="SMR" id="A0A8B7HAW4"/>
    <dbReference type="Ensembl" id="ENSMICT00000065864.1">
        <property type="protein sequence ID" value="ENSMICP00000042700.1"/>
        <property type="gene ID" value="ENSMICG00000042087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878714"/>
    <dbReference type="KEGG" id="mmur:105878714"/>
    <dbReference type="CTD" id="10286"/>
    <dbReference type="GeneTree" id="ENSGT00390000014494"/>
    <dbReference type="OMA" id="SAWQESI"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="139"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="225" mass="26131" checksum="9112718EEFD96890" modified="2022-01-19" version="1">MAGTGLVAGEVVVDALPYFDQGYEAPGVREAAAALVEEETRRYRPTKNYLSYLTAPDYSAFETDIMRNEFERLAARQPIELLSMKRYELPAPSSGQKNDITAWQECVNNSMAQLEHQAVRIENLELMSQHGCNAWKVYNENLVHMIEHAQKELQKLRKHIQDLNWQRKNMQLTAGSKLREMESNWVSLVSKNYEIERTIVQLENEIYQIKQQHGEANKENIRQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HCB3</accession>
    <name>A0A8B7HCB3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin thioesterase</fullName>
            <ecNumber evidence="15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">OTUB1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase C65 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03005869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633346.1">
        <property type="nucleotide sequence ID" value="XM_012777892.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HCB3"/>
    <dbReference type="Ensembl" id="ENSMICT00000061989.1">
        <property type="protein sequence ID" value="ENSMICP00000045610.1"/>
        <property type="gene ID" value="ENSMICG00000016916.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878462"/>
    <dbReference type="KEGG" id="mmur:105878462"/>
    <dbReference type="CTD" id="55611"/>
    <dbReference type="GeneTree" id="ENSGT00390000006979"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000780">
        <property type="term" value="P:negative regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22763">
        <property type="entry name" value="OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.20:FF:000001">
        <property type="entry name" value="Ubiquitin thioesterase OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.60:FF:000003">
        <property type="entry name" value="Ubiquitin thioesterase OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016615">
        <property type="entry name" value="Otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF19">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013503">
        <property type="entry name" value="Ubiquitin_thioesterase_Otubain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="18">
        <location>
            <begin position="80"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="17">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="17">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="17">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="17">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="site" description="Interacts with free ubiquitin" evidence="17">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR013503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR013503-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="271" mass="31297" checksum="32F78EFA56776F79" modified="2022-01-19" version="1">MAAEEPQQQKQEPLGSDSEGVNCLAYDEAIMAQQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKIKDLHKKYSYIRKTRPDGNCFYRAFGFSHLEALLDDSKELQRFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQTSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALNVSIQVEYMDRGEGGTTNPHVFPEGSEPKVYLLYRPGHYDILYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HDE7</accession>
    <name>A0A8B7HDE7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">G protein subunit alpha transducin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GNAT3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(i/o/t/z) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015411">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634948.1">
        <property type="nucleotide sequence ID" value="XM_012779494.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HDE7"/>
    <dbReference type="Ensembl" id="ENSMICT00000065133.1">
        <property type="protein sequence ID" value="ENSMICP00000046405.1"/>
        <property type="gene ID" value="ENSMICG00000043377.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879340"/>
    <dbReference type="KEGG" id="mmur:105879340"/>
    <dbReference type="CTD" id="346562"/>
    <dbReference type="GeneTree" id="ENSGT00940000161422"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007603">
        <property type="term" value="P:phototransduction, visible light"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0050913">
        <property type="term" value="P:sensory perception of bitter taste"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050916">
        <property type="term" value="P:sensory perception of sweet taste"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050917">
        <property type="term" value="P:sensory perception of umami taste"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000720">
        <property type="entry name" value="Guanine nucleotide-binding protein G(k) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000256">
        <property type="entry name" value="Guanine nucleotide-binding protein G(t) subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001408">
        <property type="entry name" value="Gprotein_alpha_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF66">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN G(T) SUBUNIT ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00441">
        <property type="entry name" value="GPROTEINAI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="354" mass="40220" checksum="EC687ADF6BAF95E5" modified="2022-01-19" version="1">MGSKISSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQMKIIHKNGYSEQECIEFKAVVYSNTLQSILAIVKAMTTLGIDYVNPGSAEDQEQLYAMANTLEDGGMTPQLAEVIKRLWKDPGIQACFERASEYQLNDSAAYYLNDLDRITAPGYVPNEQDVLHSRVKTTGIIETQFSFKDLHFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDEEVNRMHESLHLFNSICNHKYFATTSIVLFLNKKDLFQEKVTKVHLSICFPEYTGPNTFEDAGNYIKNQFLDLNLKKEDKEIYAHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HH29</accession>
    <name>A0A8B7HH29_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcription factor Sp8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SP8</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015582">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636438.1">
        <property type="nucleotide sequence ID" value="XM_012780984.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HH29"/>
    <dbReference type="Ensembl" id="ENSMICT00000051037.2">
        <property type="protein sequence ID" value="ENSMICP00000018138.1"/>
        <property type="gene ID" value="ENSMICG00000037978.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880174"/>
    <dbReference type="KEGG" id="mmur:105880174"/>
    <dbReference type="CTD" id="221833"/>
    <dbReference type="GeneTree" id="ENSGT00940000162033"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009953">
        <property type="term" value="P:dorsal/ventral pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22538">
        <property type="entry name" value="SP8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF25">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="374"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="507" mass="50398" checksum="961EA7CD39B08878" modified="2022-01-19" version="1">MATSLLGEEPRLGSTPLAMLAATCNKIGSPSPSPSSLSDSSSSFGKGFHPWKRSSSSSSGSCNVVGSSLSSFGVSGASRNGGSSSAAAAAAAAAAAAAALVSDSFSCGGSPGSSAFSLTSSSAAAAAAAAAAAASSSPFANDYSVFQAPGVSGGSGGGGGGGGGGSSAHSQDGSHQPVFISKVHTSVDGLQGIYPRVGMAHPYESWFKPSHPGLGAAGEVGSAGASSWWDVGAGWIDVQNPNGAAALPGSLHPAAGGLQTSLHSPLGGYNSDYSGLSHSAFSSGASSHLLSPAGQHLMDGFKPVLPGSYPDSAPSPLAGAGGSMLSAGPSAPLGGSPRSSARRYSGRATCDCPNCQEAERLGPAGASLRRKGLHSCHIPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELQRHLRTHTGEKRFACPVCNKRFMRSDHLSKHVKTHSGGGGGGSAGSGSGGKKGSDTDSEHSAAGSPPCHSPELLQPPEPGHRNGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HPH6</accession>
    <name>A0A8B7HPH6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Guanylate cyclase soluble subunit beta-1</fullName>
            <ecNumber evidence="4">4.6.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Guanylate cyclase soluble subunit beta-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Soluble guanylate cyclase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GUCY1B1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP = 3',5'-cyclic GMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13665"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="EC" id="4.6.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03018624">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639076.1">
        <property type="nucleotide sequence ID" value="XM_012783622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HPH6"/>
    <dbReference type="Ensembl" id="ENSMICT00000051712.2">
        <property type="protein sequence ID" value="ENSMICP00000019508.1"/>
        <property type="gene ID" value="ENSMICG00000015314.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881770"/>
    <dbReference type="KEGG" id="mmur:105881770"/>
    <dbReference type="CTD" id="2983"/>
    <dbReference type="GeneTree" id="ENSGT00940000157483"/>
    <dbReference type="OrthoDB" id="6127067at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008074">
        <property type="term" value="C:guanylate cyclase complex, soluble"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004383">
        <property type="term" value="F:guanylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019934">
        <property type="term" value="P:cGMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070482">
        <property type="term" value="P:response to oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1230:FF:000005">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1520.10:FF:000001">
        <property type="entry name" value="Guanylate cyclase soluble subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.260:FF:000001">
        <property type="entry name" value="guanylate cyclase soluble subunit beta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1520.10">
        <property type="entry name" value="H-NOX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.260">
        <property type="entry name" value="Haem NO binding associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018297">
        <property type="entry name" value="A/G_cyclase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038158">
        <property type="entry name" value="H-NOX_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011644">
        <property type="entry name" value="Heme_NO-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011645">
        <property type="entry name" value="HNOB_dom_associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042463">
        <property type="entry name" value="HNOB_dom_associated_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655:SF2">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45655">
        <property type="entry name" value="GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07700">
        <property type="entry name" value="HNOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07701">
        <property type="entry name" value="HNOBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00452">
        <property type="entry name" value="GUANYLATE_CYCLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0141">cGMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="421"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="619" mass="70521" checksum="2DFE4537FDE02AA1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HQ98</accession>
    <name>A0A8B7HQ98_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Stannin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SNN</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in the toxic effects of organotins. Plays a role in endosomal maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the stannin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020920">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640019.1">
        <property type="nucleotide sequence ID" value="XM_012784565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HQ98"/>
    <dbReference type="Ensembl" id="ENSMICT00000063936.1">
        <property type="protein sequence ID" value="ENSMICP00000049576.1"/>
        <property type="gene ID" value="ENSMICG00000041957.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105882304"/>
    <dbReference type="CTD" id="8303"/>
    <dbReference type="GeneTree" id="ENSGT00390000009447"/>
    <dbReference type="OrthoDB" id="9448252at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20257">
        <property type="entry name" value="Stannin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.20:FF:000001">
        <property type="entry name" value="stannin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.20">
        <property type="entry name" value="membrane protein stannin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015137">
        <property type="entry name" value="SNN_cytoplasm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015136">
        <property type="entry name" value="SNN_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015135">
        <property type="entry name" value="SNN_transmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038747">
        <property type="entry name" value="Stannin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027435">
        <property type="entry name" value="Stannin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28564">
        <property type="entry name" value="STANNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28564:SF1">
        <property type="entry name" value="STANNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09051">
        <property type="entry name" value="SNN_cytoplasm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09050">
        <property type="entry name" value="SNN_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09049">
        <property type="entry name" value="SNN_transmemb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Stannin transmembrane" evidence="13">
        <location>
            <begin position="2"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Stannin unstructured linker" evidence="14">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Stannin cytoplasmic" evidence="15">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00073781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="88" mass="9525" checksum="1E8DA733317226DF" modified="2022-01-19" version="1">MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSARGPCVERKAKLMTPNGPEVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HR09</accession>
    <name>A0A8B7HR09_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase Midline-1</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">RING finger protein Midline-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase Midline-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Tripartite motif-containing protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">MID1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 31">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03035902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640292.1">
        <property type="nucleotide sequence ID" value="XM_012784838.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640293.1">
        <property type="nucleotide sequence ID" value="XM_012784839.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640294.1">
        <property type="nucleotide sequence ID" value="XM_012784840.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640295.1">
        <property type="nucleotide sequence ID" value="XM_012784841.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640296.1">
        <property type="nucleotide sequence ID" value="XM_012784842.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640297.1">
        <property type="nucleotide sequence ID" value="XM_012784843.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640298.1">
        <property type="nucleotide sequence ID" value="XM_012784844.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HR09"/>
    <dbReference type="Ensembl" id="ENSMICT00000002489.3">
        <property type="protein sequence ID" value="ENSMICP00000002273.2"/>
        <property type="gene ID" value="ENSMICG00000002488.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039403.2">
        <property type="protein sequence ID" value="ENSMICP00000030564.2"/>
        <property type="gene ID" value="ENSMICG00000002488.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882448"/>
    <dbReference type="KEGG" id="mmur:105882448"/>
    <dbReference type="CTD" id="4281"/>
    <dbReference type="GeneTree" id="ENSGT00940000155821"/>
    <dbReference type="OrthoDB" id="9049620at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032874">
        <property type="term" value="P:positive regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19836">
        <property type="entry name" value="Bbox1_MID1_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19822">
        <property type="entry name" value="Bbox2_MID1_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16753">
        <property type="entry name" value="RING-HC_MID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase Midline-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000334">
        <property type="entry name" value="E3 ubiquitin-protein ligase Midline-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000153">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000014">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.40:FF:000002">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
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    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
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    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
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    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047095">
        <property type="entry name" value="MID1_Bbox1_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027727">
        <property type="entry name" value="MID1_Bbox2_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040859">
        <property type="entry name" value="Midline-1_COS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF23">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MIDLINE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18568">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="25">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="28">
        <location>
            <begin position="320"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="27">
        <location>
            <begin position="381"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="26">
        <location>
            <begin position="466"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031380"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002273.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="667" mass="75255" checksum="E14E5AFB78FB74C9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRT5</accession>
    <name>A0A8B7HRT5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ectonucleoside triphosphate diphosphohydrolase 8</fullName>
            <ecNumber evidence="5">3.6.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ENTPD8</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36795"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="5"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639909.1">
        <property type="nucleotide sequence ID" value="XM_012784455.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRT5"/>
    <dbReference type="Ensembl" id="ENSMICT00000009542.3">
        <property type="protein sequence ID" value="ENSMICP00000008684.3"/>
        <property type="gene ID" value="ENSMICG00000009546.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882244"/>
    <dbReference type="CTD" id="377841"/>
    <dbReference type="GeneTree" id="ENSGT01150000286965"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009133">
        <property type="term" value="P:nucleoside diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009124">
        <property type="term" value="P:nucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000002">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000068">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF31">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008684.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="497" mass="53754" checksum="8D45A6556CF4FB38" modified="2022-01-19" version="1">MGLSWKEKVFLALLGSAVALGLTALVLVLVEAVNVLLPPDTKFGIVFDAGSSHTSLFVYRWPVDKENGTGVVSQALACQVEGPGISSYASNPAQAGESLRGCLEEALALIPEAQHRGTPMFLGATAGMRLLSQKNSSQAGDIFAAVTRVLGGSPVDFQGAKLLDGQDEGAFGWITINYVLGLLIKYSFSGKWTRPPEGTLVGALDLGGASTQIAFVPRGPVLDTSTQATFHLYGSSYSVYTRSYLCYGRDQMLSRLLAGLVQRQNHSAGPVGHPCYHSGYRTTLPLASLYESPCVHTAAPQNLTQNLTVEGTGNPGACVVAIRELFNCSSHQGLGDCAFDRVHQPPLWGQFYAFSNFYYTFHFLNLTSQQSLGAANDTVWEFCQESWEQVEASYPGQDRWLRDYCACGLYILTLLTEGYGFSEETWPSIQFRKQAGGMDIGWTLGYMLNLTGMIPAEAPAQWRAESYGIWAAGVAFVVLTLLAVLGAAAVQFIWPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HSR1</accession>
    <name>A0A8B7HSR1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 27">Neuromodulin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23 27">Axonal membrane protein GAP-43</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24 27">Growth-associated protein 43</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">GAP43</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22 27">This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="26 27">Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="27">Cell membrane</location>
            <topology evidence="27">Peripheral membrane protein</topology>
            <orientation evidence="27">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5 27">Cell projection</location>
            <location evidence="5 27">Growth cone membrane</location>
            <topology evidence="5 27">Peripheral membrane protein</topology>
            <orientation evidence="5 27">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="25 27">Synapse</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6 27">Cell projection</location>
            <location evidence="6 27">Filopodium membrane</location>
            <topology evidence="6 27">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 27">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 27">Cell projection</location>
            <location evidence="1 27">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 27">Cell projection</location>
            <location evidence="3 27">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4 27">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="27">Cytoplasmic surface of growth cone and synaptic plasma membranes.</text>
    </comment>
    <comment type="PTM">
        <text evidence="27">Palmitoylated. Palmitoylation is essential for plasma membrane association.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 27">Belongs to the neuromodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001132">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641037.1">
        <property type="nucleotide sequence ID" value="XM_012785583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HSR1"/>
    <dbReference type="Ensembl" id="ENSMICT00000072318.1">
        <property type="protein sequence ID" value="ENSMICP00000050715.1"/>
        <property type="gene ID" value="ENSMICG00000049221.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882875"/>
    <dbReference type="KEGG" id="mmur:105882875"/>
    <dbReference type="CTD" id="2596"/>
    <dbReference type="GeneTree" id="ENSGT00730000111265"/>
    <dbReference type="OrthoDB" id="9397439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032584">
        <property type="term" value="C:growth cone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035727">
        <property type="term" value="F:lysophosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901981">
        <property type="term" value="F:phosphatidylinositol phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016198">
        <property type="term" value="P:axon choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031103">
        <property type="term" value="P:axon regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042246">
        <property type="term" value="P:tissue regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000075">
        <property type="entry name" value="Neuromodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001422">
        <property type="entry name" value="Neuromodulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017454">
        <property type="entry name" value="Neuromodulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018947">
        <property type="entry name" value="Neuromodulin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033137">
        <property type="entry name" value="Neuromodulin_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018243">
        <property type="entry name" value="Neuromodulin_palmitoyl_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10699:SF15">
        <property type="entry name" value="NEUROMODULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06614">
        <property type="entry name" value="Neuromodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10580">
        <property type="entry name" value="Neuromodulin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00215">
        <property type="entry name" value="NEUROMODULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00412">
        <property type="entry name" value="NEUROMODULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00413">
        <property type="entry name" value="NEUROMODULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 27" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="10 27" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20 27" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11 27" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 27" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="14 27" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13 27" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="21 27" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="16 27" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="19 27" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12 27" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 27" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Neuromodulin N-terminal" evidence="30">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Neuromodulin C-terminal" evidence="29">
        <location>
            <begin position="68"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="28">
        <location>
            <begin position="171"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="28">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00021591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00025215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00033250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00046855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU368113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF06614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF10580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="241" mass="25003" checksum="FC2AE9A52395C907" modified="2022-01-19" version="1">MLCCMRRTKQVEKNDEDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAQAAEAEANEKKDEAPVADGVEKKGEGAATAEAAPATGPKPDETGKAGETPSEEKKGEGAPDAATEPAAPPAPAPSEEKAGSAETESATKASTDNSPSSKAEDGPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETAESSQAEEKIEAVDETKPKESARQDEGQEEEREADQEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HUH5</accession>
    <name>A0A8B7HUH5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox protein engrailed-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EN2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Engrailed homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015082">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641708.1">
        <property type="nucleotide sequence ID" value="XM_012786254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HUH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000030453.2">
        <property type="protein sequence ID" value="ENSMICP00000039379.1"/>
        <property type="gene ID" value="ENSMICG00000036243.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105883219"/>
    <dbReference type="KEGG" id="mmur:105883219"/>
    <dbReference type="CTD" id="2020"/>
    <dbReference type="GeneTree" id="ENSGT00940000159935"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021953">
        <property type="term" value="P:central nervous system neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071542">
        <property type="term" value="P:dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990403">
        <property type="term" value="P:embryonic brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030902">
        <property type="term" value="P:hindbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000167">
        <property type="entry name" value="Homeobox protein engrailed-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000747">
        <property type="entry name" value="HD_engrailed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019549">
        <property type="entry name" value="Homeobox-engrailed_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019737">
        <property type="entry name" value="Homeobox-engrailed_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF5">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10525">
        <property type="entry name" value="Engrail_1_C_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00026">
        <property type="entry name" value="ENGRAILED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00033">
        <property type="entry name" value="ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="237"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="91"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU510713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="328" mass="34014" checksum="7AAE31DEC9B5432E" modified="2022-01-19" version="1">MEENDPKPSEAAAVEGQRQPESSPSGGSGGGGSPGDADTGRRRALMLPAVLQAPGNHQHPHRITNFFIDNILRPEFGRRKDVGTCCAGAGGGRGGGEGGAGGAEGGGGAGGAEQQLLGSGAREPRQNPPCAPGAGVQLPAGGGDSSGDGEGGSKTLSLHGGAKKGSDPGGPLDGALKARGLGGGDLSVSSDSDSSQASANLGAQPMLWPAWVYCTRYSDRPSSGPRSRKPKKKNPNKEDKRPRTAFTAEQLQRLKAEFQTNRYLTEQRRQSLAQELSLNESQIKIWFQNKRAKIKKATGNKNTLAVHLMAQGLYNHSTTAKEGKSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HWZ1</accession>
    <name>A0A8B7HWZ1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PWWP domain containing 3B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PWWP3B</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PWWP3A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642672.1">
        <property type="nucleotide sequence ID" value="XM_012787218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HWZ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000006192.3">
        <property type="protein sequence ID" value="ENSMICP00000005645.2"/>
        <property type="gene ID" value="ENSMICG00000006196.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883777"/>
    <dbReference type="KEGG" id="mmur:105883777"/>
    <dbReference type="CTD" id="139221"/>
    <dbReference type="GeneTree" id="ENSGT00390000001700"/>
    <dbReference type="OrthoDB" id="10013064at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06080">
        <property type="entry name" value="PWWP_MUM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000063">
        <property type="entry name" value="PWWP domain-containing DNA repair factor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035504">
        <property type="entry name" value="MUM1-like_PWWP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040263">
        <property type="entry name" value="PWP3A_3B_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048795">
        <property type="entry name" value="PWP3A_3B_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048765">
        <property type="entry name" value="PWP3A_3B_4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31333">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31333:SF3">
        <property type="entry name" value="PWWP DOMAIN-CONTAINING DNA REPAIR FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20884">
        <property type="entry name" value="MUM1-like_PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20886">
        <property type="entry name" value="PWP3A-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20887">
        <property type="entry name" value="PWP3A-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWWP" evidence="5">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="MUM1-like PWWP" evidence="3">
        <location>
            <begin position="384"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="4">
        <location>
            <begin position="536"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005645.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="690" mass="78674" checksum="95D2458DFD679D78" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I1L9</accession>
    <name>A0A8B7I1L9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="40">Multifunctional protein CAD</fullName>
            <ecNumber evidence="10">2.1.3.2</ecNumber>
            <ecNumber evidence="9">3.5.1.2</ecNumber>
            <ecNumber evidence="8">3.5.2.3</ecNumber>
            <ecNumber evidence="32">6.3.4.16</ecNumber>
            <ecNumber evidence="7">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="41">Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="46" type="primary">CAD</name>
    </gene>
    <organism evidence="46 47">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="46" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="46" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="46" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="38">Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="39">Homohexamer. Interacts with CIPC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="31">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="28">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="29">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="30">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="10"/>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EC" id="3.5.2.3" evidence="8"/>
    <dbReference type="EC" id="6.3.4.16" evidence="32"/>
    <dbReference type="EC" id="6.3.5.5" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03011908">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643700.1">
        <property type="nucleotide sequence ID" value="XM_012788246.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039142.2">
        <property type="protein sequence ID" value="ENSMICP00000033417.1"/>
        <property type="gene ID" value="ENSMICG00000017084.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884399"/>
    <dbReference type="CTD" id="790"/>
    <dbReference type="GeneTree" id="ENSGT00940000157241"/>
    <dbReference type="OrthoDB" id="434at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="CPSGATASE"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="24" id="KW-0007">Acetylation</keyword>
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    <keyword evidence="21 42" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="22" id="KW-0460">Magnesium</keyword>
    <keyword evidence="25" id="KW-0464">Manganese</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="27" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18 42" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="47" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ATP-grasp" evidence="44">
        <location>
            <begin position="519"/>
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    <feature type="domain" description="ATP-grasp" evidence="44">
        <location>
            <begin position="1052"/>
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    </feature>
    <feature type="domain" description="MGS-like" evidence="45">
        <location>
            <begin position="1308"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="43">
        <location>
            <begin position="1811"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="43">
        <location>
            <begin position="1866"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012860"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00048492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00059164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00063193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00070057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00077900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="44">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="45">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="46">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="47">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2225" mass="243043" checksum="86535A5175E4EAB7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I2C4</accession>
    <name>A0A8B7I2C4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 513</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF513</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transcriptional regulator that plays a role in retinal development and maintenance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Binds DNA. Can associate with the proximal promoter regions of PAX6 and SP4, and their known targets including ARR3, RHO, OPN1MW2 and OPN1SW.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643729.1">
        <property type="nucleotide sequence ID" value="XM_012788275.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I2C4"/>
    <dbReference type="Ensembl" id="ENSMICT00000066994.1">
        <property type="protein sequence ID" value="ENSMICP00000042215.1"/>
        <property type="gene ID" value="ENSMICG00000015886.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884411"/>
    <dbReference type="KEGG" id="mmur:105884411"/>
    <dbReference type="CTD" id="130557"/>
    <dbReference type="GeneTree" id="ENSGT00940000158687"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000049">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000123">
        <property type="entry name" value="transcriptional repressor CTCF isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000395">
        <property type="entry name" value="zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000584">
        <property type="entry name" value="Zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000713">
        <property type="entry name" value="Zinc finger protein 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000962">
        <property type="entry name" value="zinc finger protein 513 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000558">
        <property type="entry name" value="zinc finger protein 513 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050688">
        <property type="entry name" value="Zinc_finger/UBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF66">
        <property type="entry name" value="ZINC FINGER PROTEIN 513"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="492"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="541" mass="58017" checksum="E31738A817FADB55" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I561</accession>
    <name>A0A8B7I561_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Integrin alpha-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">CD49 antigen-like family member C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Galactoprotein B3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">VLA-3 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ITGA3</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-3 associates with beta-1. Interacts with HPS5. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cell projection</location>
            <location evidence="21">Filopodium membrane</location>
            <topology evidence="21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Invadopodium membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <topology evidence="28">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 28">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645187.1">
        <property type="nucleotide sequence ID" value="XM_012789733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I561"/>
    <dbReference type="Ensembl" id="ENSMICT00000069474.1">
        <property type="protein sequence ID" value="ENSMICP00000041827.1"/>
        <property type="gene ID" value="ENSMICG00000007204.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885102"/>
    <dbReference type="CTD" id="3675"/>
    <dbReference type="GeneTree" id="ENSGT00940000157746"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000004">
        <property type="entry name" value="integrin alpha-3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000007">
        <property type="entry name" value="Integrin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000012">
        <property type="entry name" value="Integrin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1530:FF:000004">
        <property type="entry name" value="Integrin subunit alpha 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF89">
        <property type="entry name" value="INTEGRIN ALPHA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 28" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 28" id="KW-0401">Integrin</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="16 28" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 28" id="KW-0732">Signal</keyword>
    <keyword evidence="6 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 28" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044038195" description="Integrin alpha-3" evidence="28">
        <location>
            <begin position="33"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="27">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="27">
        <location>
            <begin position="236"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="27">
        <location>
            <begin position="293"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="27">
        <location>
            <begin position="356"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="27">
        <location>
            <begin position="415"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="30">
        <location>
            <begin position="462"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="31">
        <location>
            <begin position="615"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="32">
        <location>
            <begin position="763"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="857"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00065515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00068407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00080510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00082278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1051" mass="116916" checksum="D8150DDCA15584C3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I797</accession>
    <name>A0A8B7I797_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein BING4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">WDR46</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with DDX21, NCL, NOP2 and EBNA1BP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012791356.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000000918.3">
        <property type="protein sequence ID" value="ENSMICP00000000828.2"/>
        <property type="gene ID" value="ENSMICG00000000916.3"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
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            <begin position="441"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_020135911.1">
        <property type="nucleotide sequence ID" value="XM_020280322.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135912.1">
        <property type="nucleotide sequence ID" value="XM_020280323.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_020280324.2"/>
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    <dbReference type="KEGG" id="mmur:105875095"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
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        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR QRICH1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF25561">
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        <property type="match status" value="1"/>
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        <location>
            <begin position="474"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="ZMYM2-like/QRICH1 C-terminal" evidence="5">
        <location>
            <begin position="601"/>
            <end position="759"/>
        </location>
    </feature>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
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    <feature type="region of interest" description="Disordered" evidence="4">
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            <end position="443"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF12012"/>
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    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031921.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="777" mass="86611" checksum="DDD9517C6A81ABFC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WVP7</accession>
    <name>A0A8B7WVP7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transcription factor COE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Early B-cell factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">EBF1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Key pioneer transcription factor of B-cell specification and commitment. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer. Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes. Interacts with CCR4-NOT component CNOT3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the COE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027434">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027435">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139253.1">
        <property type="nucleotide sequence ID" value="XM_020283664.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WVP7"/>
    <dbReference type="SMR" id="A0A8B7WVP7"/>
    <dbReference type="Ensembl" id="ENSMICT00000051257.2">
        <property type="protein sequence ID" value="ENSMICP00000031709.2"/>
        <property type="gene ID" value="ENSMICG00000010036.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880488"/>
    <dbReference type="CTD" id="1879"/>
    <dbReference type="GeneTree" id="ENSGT00950000182859"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11606">
        <property type="entry name" value="COE_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01175">
        <property type="entry name" value="IPT_COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3180:FF:000004">
        <property type="entry name" value="Transcription factor COE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4280:FF:000001">
        <property type="entry name" value="transcription factor COE1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001696">
        <property type="entry name" value="Transcription factor COE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3180">
        <property type="entry name" value="Transcription factor COE1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032200">
        <property type="entry name" value="COE_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038173">
        <property type="entry name" value="COE_DBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032201">
        <property type="entry name" value="COE_HLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038006">
        <property type="entry name" value="COE_IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003523">
        <property type="entry name" value="Transcription_factor_COE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018350">
        <property type="entry name" value="Transcription_factor_COE_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10747">
        <property type="entry name" value="TRANSCRIPTION FACTOR COE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16422">
        <property type="entry name" value="COE1_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16423">
        <property type="entry name" value="COE1_HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01345">
        <property type="entry name" value="COE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="3 19" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 19" id="KW-0804">Transcription</keyword>
    <keyword evidence="10 19" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="IPT/TIG" evidence="21">
        <location>
            <begin position="261"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031709.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="591" mass="64464" checksum="E47797B6FC1E5071" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WVT7</accession>
    <name>A0A8B7WVT7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 491</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC109729229</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027810">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027811">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WVT7"/>
    <dbReference type="Ensembl" id="ENSMICT00000047106.2">
        <property type="protein sequence ID" value="ENSMICP00000024792.1"/>
        <property type="gene ID" value="ENSMICG00000034536.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182755"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000838">
        <property type="entry name" value="Zinc finger protein 14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000184">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000165">
        <property type="entry name" value="Zinc finger protein 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000371">
        <property type="entry name" value="Zinc finger protein 555"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000156">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000564">
        <property type="entry name" value="zinc finger protein 699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 709-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="479"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="505" mass="59224" checksum="6737F37E8BC658E8" modified="2022-01-19" version="1">MFQDSVAFEDVAVNFTLEEWALLDPSQKNLYRDVMWETLRNLASIGKQWKDQNIEDQYKNPRRNLRSFLGERLFESKEGNRFGETFSLVPDHMVNKKTPHSIKPCGSSVRADISIGHSLRNRHVKANNGPKPHKYQEHGEMLYKHKQRGKAFSSHHPFQTHERPPTEKKPYECKECGKTFIALTSIRKHMVMHSGDGRYKCKFCGKALDCLSVCIIHERTHTGEKPYECKQCGKAFSLSSSVRIHERTHTGEKPYECKECGRAFKFSSSFRRHERTHTGEKPYECKECGRAFNRPSSFRRHQRTHIGEKPYECKQCGKALSCLISFQRHMSMHTGDRPHKCKICRRAFYSPSLFQRHERTHTGKKPYECKQCEKAFSCSTSLQYHKRTHTGEKPYECKQCGKTFRSARYIRIHERIHTGEKPYECKQCGKAFRCVSSFRRHERTHTGEKPYQCKHCAKTFPCSMYTRIHERIHTGEKPYACRECGKAFICSAYCRKHERTHNINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X300</accession>
    <name>A0A8B7X300_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Hepatic triacylglycerol lipase</fullName>
            <ecNumber evidence="8">3.1.1.3</ecNumber>
            <ecNumber evidence="6">3.1.1.32</ecNumber>
            <ecNumber evidence="7">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lipase member C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Lysophospholipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Phospholipase A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="38" type="primary">LIPC</name>
    </gene>
    <organism evidence="38 39">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="38" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="38" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="38" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:38392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40475"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:35020"/>
            <dbReference type="ChEBI" id="CHEBI:76478"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40476"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:74669"/>
            <dbReference type="ChEBI" id="CHEBI:76083"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:38700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38511"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:38512"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41384"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64563"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:41385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
            <dbReference type="ChEBI" id="CHEBI:75938"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:38652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40499"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64765"/>
            <dbReference type="ChEBI" id="CHEBI:74617"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:40500"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18689"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57875"/>
            <dbReference type="EC" id="3.1.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 35">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="8"/>
    <dbReference type="EC" id="3.1.1.32" evidence="6"/>
    <dbReference type="EC" id="3.1.1.5" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03004805">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004806">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020141638.1">
        <property type="nucleotide sequence ID" value="XM_020286049.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020141639.1">
        <property type="nucleotide sequence ID" value="XM_020286050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X300"/>
    <dbReference type="Ensembl" id="ENSMICT00000068505.1">
        <property type="protein sequence ID" value="ENSMICP00000048254.1"/>
        <property type="gene ID" value="ENSMICG00000005871.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881364"/>
    <dbReference type="KEGG" id="mmur:105881364"/>
    <dbReference type="CTD" id="3990"/>
    <dbReference type="GeneTree" id="ENSGT00940000157602"/>
    <dbReference type="OrthoDB" id="199913at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034185">
        <property type="term" value="F:apolipoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004465">
        <property type="term" value="F:lipoprotein lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008970">
        <property type="term" value="F:phospholipase A1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034375">
        <property type="term" value="P:high-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034374">
        <property type="term" value="P:low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034372">
        <property type="term" value="P:very-low-density lipoprotein particle remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00707">
        <property type="entry name" value="Pancreat_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01758">
        <property type="entry name" value="PLAT_LPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000010">
        <property type="entry name" value="hepatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000101">
        <property type="entry name" value="Hepatic triacylglycerol lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013818">
        <property type="entry name" value="Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002333">
        <property type="entry name" value="Lipase_hep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016272">
        <property type="entry name" value="Lipase_LIPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033906">
        <property type="entry name" value="Lipase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000734">
        <property type="entry name" value="TAG_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610:SF2">
        <property type="entry name" value="HEPATIC TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11610">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00151">
        <property type="entry name" value="Lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000865">
        <property type="entry name" value="Lipoprotein_lipase_LIPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00824">
        <property type="entry name" value="HEPLIPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00821">
        <property type="entry name" value="TAGLIPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00308">
        <property type="entry name" value="LH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="33" id="KW-0106">Calcium</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0345">HDL</keyword>
    <keyword evidence="11" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="33" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="39" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 36" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="36">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135532" description="Hepatic triacylglycerol lipase" evidence="36">
        <location>
            <begin position="24"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PLAT" evidence="37">
        <location>
            <begin position="353"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="32">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="32">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="33">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00049452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="PIRSR" id="PIRSR000865-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU004262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="501" mass="56203" checksum="66C2601CED464D1F" modified="2022-01-19" version="1">MESAPCVPIFLVLCIFIQSSAHGQSLGPEPSGRRSQAVETKKTLQETKTRFLLLGDKTNEGCQIQLNRPDTLQECGFNSSQPLVMIIHGWSVDGKLENWIWQLVAALKSRPAQPVNVGVADWLTLAYQPYTIAVRNTRLTGQEVAALLRWLEESVQFSPSNVHLIGYSLGAHVSGFAGSYLGRKHKIGRITGLDAAGPLFEGSPPSDRLSPDDANFVDAIHTFTREHMGLSVGIKRPVAHYDFYPNGGSFQPGCHFLELYKHIAEHGLHATITKTIKCSHERSVHLFIDSLLHDGMQSTAYLCSDMDSFSQGRCLSCRKGRCNTLGYHVHQQPQSKSKKLFLVTRAQSPFKVYHYQFKIRFVNHIEKPIEPTFTMSLLGTKEEMQKIPITLGGGITSNKTYSFLVTLDSDIGELIMIKFKWENSAVWTNVWNTVQTIIPWGAEPCCHSGLLLKTIRVKAGETQQRMTFCLENTDDLQLHPTQEKIFVKCELSSKKSKRKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJY0</accession>
    <name>A0A8C5UJY0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Kinetochore associated 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KNTC1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024819">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024820">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000000333.3">
        <property type="protein sequence ID" value="ENSMICP00000000304.3"/>
        <property type="gene ID" value="ENSMICG00000000331.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007883"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055403">
        <property type="entry name" value="ARM_KNTC1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055404">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055405">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055402">
        <property type="entry name" value="KNTC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019527">
        <property type="entry name" value="RZZ-complex_KNTC1/ROD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24520">
        <property type="entry name" value="ARM_KNTC1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24516">
        <property type="entry name" value="ARM_KNTC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24515">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24506">
        <property type="entry name" value="KNTC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10493">
        <property type="entry name" value="Rod_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 first ARM-repeats" evidence="5">
        <location>
            <begin position="402"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 second ARM-repeats" evidence="4">
        <location>
            <begin position="754"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="domain" description="KNTC1 third ARM-repeats" evidence="3">
        <location>
            <begin position="1325"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="domain" description="RZZ complex subunit KNTC1/ROD C-terminal" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="2111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000304.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2190" mass="249254" checksum="2CA1B6E5651199C3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5ULI7</accession>
    <name>A0A8C5ULI7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sialate O-acetylesterase</fullName>
            <ecNumber evidence="2">3.1.1.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Sialic acid-specific 9-O-acetylesterase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SIAE</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes. Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-acetyl-9-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28999"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35418"/>
            <dbReference type="EC" id="3.1.1.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22601"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an Ac-O-9-sialoglycoconjugate + H2O = a sialoglycoconjugate + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80763"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:231691"/>
            <dbReference type="ChEBI" id="CHEBI:231692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:80764"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.53" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03007093">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5ULI7"/>
    <dbReference type="Ensembl" id="ENSMICT00000001681.3">
        <property type="protein sequence ID" value="ENSMICP00000001526.3"/>
        <property type="gene ID" value="ENSMICG00000001679.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010608"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001681">
        <property type="term" value="F:sialate O-acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000008">
        <property type="entry name" value="Sialate O-acetylesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005181">
        <property type="entry name" value="SASA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039329">
        <property type="entry name" value="SIAE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22901:SF0">
        <property type="entry name" value="SIALATE O-ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03629">
        <property type="entry name" value="SASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034632840" description="Sialate O-acetylesterase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Sialate O-acetylesterase" evidence="14">
        <location>
            <begin position="119"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001526.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="518" mass="57695" checksum="ED2CEB5E7297686E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNB9</accession>
    <name>A0A8C5UNB9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox D12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXD12</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Abd-B homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608821.1">
        <property type="nucleotide sequence ID" value="XM_012753367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNB9"/>
    <dbReference type="Ensembl" id="ENSMICT00000002170.3">
        <property type="protein sequence ID" value="ENSMICP00000001987.2"/>
        <property type="gene ID" value="ENSMICG00000002172.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865049"/>
    <dbReference type="KEGG" id="mmur:105865049"/>
    <dbReference type="CTD" id="3238"/>
    <dbReference type="GeneTree" id="ENSGT00940000159938"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007389">
        <property type="term" value="P:pattern specification process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000130">
        <property type="entry name" value="Homeobox protein Hox-D12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46440:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46440">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="202"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001987.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="270" mass="28985" checksum="123D32187DB4E290" modified="2022-01-19" version="1">MCERSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAPAQSAGATAFGGFSQPYLAGSGPLGLQPPAAKDGPEEQAKFYTPEAAAGPEERNRTRPPFAPESSLGPAVAALKAAKYDYPGVGPAAPGSATLLQGAPCAASFKDDTKGPLNLNMTVQAAGVASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQQVKIWFQNRRMKKKRVVLREQALALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQ24</accession>
    <name>A0A8C5UQ24_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-B-cell leukemia transcription factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17 18">Homeobox protein PBX1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PBX1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a heterodimer with MEIS1 which binds DNA. The PBX1-MEIS1 heterodimer binds a cAMP-responsive sequence in CYP17. It also binds a consensus region in the SOX3 promoter. PBX1 forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Forms heterodimers with HOXA1, HOXA5, HOXB7 and HOXB8 which bind the 5'-TGATTGAT-3' consensus sequence. Also forms heterodimers with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 which bind the 5'-ATCAATCAA-3' consensus sequence. Interacts with PBXIP1. Interacts with TLX1. Interacts with FOXC1. Interacts with MN1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Part of a PDX1:PBX1b:MEIS2B complex; PBX1b recruits MEIS2B to the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/PBX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003293">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003294">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003295">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQ24"/>
    <dbReference type="Ensembl" id="ENSMICT00000001279.3">
        <property type="protein sequence ID" value="ENSMICP00000001167.3"/>
        <property type="gene ID" value="ENSMICG00000001280.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154374"/>
    <dbReference type="OMA" id="CHRMRHA"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030325">
        <property type="term" value="P:adrenal gland development"/>
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        <property type="term" value="P:anterior/posterior pattern specification"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035162">
        <property type="term" value="P:embryonic hemopoiesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of stem cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:proximal/distal pattern formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of ossification"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:sex differentiation"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Pre-B-cell leukemia transcription factor 1"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="HD"/>
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        <property type="entry name" value="Homeobox_CS"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="KN_HD"/>
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        <property type="entry name" value="PBX_PBC_dom"/>
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        <property type="entry name" value="TALE_homeobox"/>
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        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
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        <property type="entry name" value="Homeobox_KN"/>
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        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 19" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0726">Sexual differentiation</keyword>
    <keyword evidence="12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="38"/>
            <end position="232"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00022473"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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            <dbReference type="ARBA" id="ARBA00022928"/>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="Ensembl" id="ENSMICP00000001167.3"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="430" mass="46653" checksum="540FFACBC5B26D3D" modified="2022-01-19" version="1">MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYNDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTB9</accession>
    <name>A0A8C5UTB9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">COG1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UTB9"/>
    <dbReference type="Ensembl" id="ENSMICT00000007483.3">
        <property type="protein sequence ID" value="ENSMICP00000006810.3"/>
        <property type="gene ID" value="ENSMICG00000007471.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017136"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000301">
        <property type="term" value="P:retrograde transport, vesicle recycling within Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033370">
        <property type="entry name" value="COG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31658:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="931"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006810.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="983" mass="109302" checksum="F0073824850D3BD0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWM7</accession>
    <name>A0A8C5UWM7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CD79a molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CD79A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026705">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UWM7"/>
    <dbReference type="Ensembl" id="ENSMICT00000004557.3">
        <property type="protein sequence ID" value="ENSMICP00000004156.2"/>
        <property type="gene ID" value="ENSMICG00000004558.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154363"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071755">
        <property type="term" value="C:IgM B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003110">
        <property type="entry name" value="Phos_immunorcpt_sig_ITAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14334:SF1">
        <property type="entry name" value="B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02189">
        <property type="entry name" value="ITAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00077">
        <property type="entry name" value="ITAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51055">
        <property type="entry name" value="ITAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034281731" evidence="7">
        <location>
            <begin position="33"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004156.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="189" mass="20768" checksum="E73BE163D9ED9BFB" modified="2022-01-19" version="1">MPRSSGVLQALPATMFLFFLLSAACLGPGCQALWVDRGPPSVTVSVGDEVHLPCQYNGSRNNVTVTWWRIIQGNHVWPPESLAAGGGAGRPPPRPFLDMGEGTKNRIITAEGIILLFCAVVPGTLLLFRKRWQNEKFGVDVQDEYEDENLYEGLNLDDCSMYEDISRGLQGTYQDVGSLNIGDVQLEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UX20</accession>
    <name>A0A8C5UX20_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RFC2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the RFC complex, an heteropentameric complex consisting of a large subunit RFC1 and four small subunits RFC2, RFC3, RFC4 and RFC5; the RFC complex interacts with PCNA. Forms an heterotetrameric complex with RFC3, RFC4 and RFC5; this complex has ATPase activity but is not stimulated by PCNA. The heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 interacts with RAD17. RFC2 also interacts with PRKAR1A; the complex may be involved in cell survival. Interacts with DDX11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UX20"/>
    <dbReference type="Ensembl" id="ENSMICT00000010212.3">
        <property type="protein sequence ID" value="ENSMICP00000009298.2"/>
        <property type="gene ID" value="ENSMICG00000010212.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000075050"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000006">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001637">
        <property type="entry name" value="replication factor C subunit 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009298.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="343" mass="37891" checksum="22058E9BFE87C666" modified="2022-01-19" version="1">MEVQASCSNAGECGSQDPAAAPSKAPGSAGHYELPWVEKYRPVKLNEVVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEQALKETMEIYSKTTRFALLPHCPLSRPEPIQSRCAVLRYTKLTDAQILARLLNVIEKENVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVDANIDEAYKILAHLWHLGYSPEDVIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKVAEGVNSLLQMAGLLARLCQKTMAPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXK7</accession>
    <name>A0A8C5UXK7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Adenylate kinase 8</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
            <ecNumber evidence="7">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-AMP transphosphorylase 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AK8</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with CFAP45 and CFAP52; CFAP45 and AK8 dimerization may create a cavity at the interface of the dimer that can accommodate AMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EC" id="2.7.4.6" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03014965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599558.1">
        <property type="nucleotide sequence ID" value="XM_012744104.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXK7"/>
    <dbReference type="Ensembl" id="ENSMICT00000010623.3">
        <property type="protein sequence ID" value="ENSMICP00000009677.2"/>
        <property type="gene ID" value="ENSMICG00000010627.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859869"/>
    <dbReference type="KEGG" id="mmur:105859869"/>
    <dbReference type="CTD" id="158067"/>
    <dbReference type="GeneTree" id="ENSGT00940000161613"/>
    <dbReference type="OrthoDB" id="522106at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd22979">
        <property type="entry name" value="DD_AK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001538">
        <property type="entry name" value="Adenylate kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001617">
        <property type="entry name" value="Adenylate kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036193">
        <property type="entry name" value="ADK_active_lid_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57774">
        <property type="entry name" value="Microbial and mitochondrial ADK, insert 'zinc finger' domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009677.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="479" mass="54907" checksum="D83668E2AFFA80C0" modified="2022-01-19" version="1">MDATTAPHRIPAEMPQYGEANHIFELMQTMLEQLLIHQPEDPVSFMIKHLNRNNDNVPKIIILGPPASGKTTIAMWLCKHLNSNLLSMQNLIGRELQFMNPEMKRQYLRTKMIPSALLVRLIEDRLEEEDCIKRGWILDGIPETREQALTIQSQGIIPRHVVVLSALDTVLIERNLGKRVDPQTGEIYHTTFDWPPESDIQNRLVVPPGISEMETARKLLEYHRNIVRIIPSYPKILKVISADQPCVDVFYQALTYVQTHHRSNAPFTPRVLLCGPTGSGKSLQAALLAQKYSLVNVCCGQLLKEAVADKTQFGELIRPFFEKQMVVPDSLVVKVLTQRLDHQDSIQKGWVMHGFPRDQDQAHMLDTLGYEPNRVFFLNVPLDSIIERLTLRRTDPVTGERYHLLYKPPPTMEIQARLLQNPKDSEEQVKLKVDLFYRNSADLEQFYKQAITLNGDQDPYTVFEYVESGIINPLPKKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V150</accession>
    <name>A0A8C5V150_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylmalonyl-CoA mutase, mitochondrial</fullName>
            <ecNumber evidence="4">5.4.99.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Methylmalonyl-CoA isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MMUT</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-methylmalonyl-CoA = succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:22888"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57326"/>
            <dbReference type="EC" id="5.4.99.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:22889"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts (the apoenzyme form) with MMAA; the interaction is GTP dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylmalonyl-CoA mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.2" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03008238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616313.1">
        <property type="nucleotide sequence ID" value="XM_012760859.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616314.1">
        <property type="nucleotide sequence ID" value="XM_012760860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V150"/>
    <dbReference type="Ensembl" id="ENSMICT00000008081.3">
        <property type="protein sequence ID" value="ENSMICP00000007362.2"/>
        <property type="gene ID" value="ENSMICG00000008076.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869194"/>
    <dbReference type="KEGG" id="mmur:105869194"/>
    <dbReference type="CTD" id="4594"/>
    <dbReference type="GeneTree" id="ENSGT00390000011892"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072341">
        <property type="term" value="F:modified amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019678">
        <property type="term" value="P:propionate metabolic process, methylmalonyl pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901290">
        <property type="term" value="P:succinyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02071">
        <property type="entry name" value="MM_CoA_mut_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03679">
        <property type="entry name" value="MM_CoA_mutase_alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.240:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.280:FF:000002">
        <property type="entry name" value="Methylmalonyl-CoA mutase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.280">
        <property type="entry name" value="Cobalamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.240">
        <property type="entry name" value="Methylmalonyl-CoA mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058549">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006944">
        <property type="entry name" value="PRK09426.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101:SF4">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48101">
        <property type="entry name" value="METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="Cobalamin (vitamin B12)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="Cobalamin (vitamin B12)-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00544">
        <property type="entry name" value="METMALONYL_COA_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="B12-binding" evidence="16">
        <location>
            <begin position="614"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007362.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="750" mass="83276" checksum="8E0E01FD60C080B1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3U4</accession>
    <name>A0A8C5V3U4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Endosome/lysosome-associated apoptosis and autophagy regulator 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ELAPOR1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">May protect cells from cell death by inducing cytosolic vacuolization and up-regulating the autophagy pathway. May play a role in apoptosis and cell proliferation through its interaction with HSPA5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts with HSPA5; may regulate the function of HSPA5 in apoptosis and cell proliferation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Late endosome membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ELAPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002899">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607105.1">
        <property type="nucleotide sequence ID" value="XM_012751651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3U4"/>
    <dbReference type="Ensembl" id="ENSMICT00000016201.3">
        <property type="protein sequence ID" value="ENSMICP00000014765.2"/>
        <property type="gene ID" value="ENSMICG00000016180.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864026"/>
    <dbReference type="KEGG" id="mmur:105864026"/>
    <dbReference type="CTD" id="57535"/>
    <dbReference type="GeneTree" id="ENSGT00940000156861"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000054">
        <property type="entry name" value="UPF0577 protein KIAA1324 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000023">
        <property type="entry name" value="UPF0577 protein KIAA1324 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056609">
        <property type="entry name" value="Elapor1-like_3rd"/>
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    <dbReference type="InterPro" id="IPR039181">
        <property type="entry name" value="Elapor1/2"/>
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    <dbReference type="InterPro" id="IPR056606">
        <property type="entry name" value="Elapor1/2_C"/>
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        <property type="entry name" value="Elapor1/2_GBD"/>
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        <property type="entry name" value="Elapor1/2_MRH"/>
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    <dbReference type="InterPro" id="IPR056610">
        <property type="entry name" value="Elapor1/2_TNFR-like"/>
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    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727:SF13">
        <property type="entry name" value="ENDOSOME_LYSOSOME-ASSOCIATED APOPTOSIS AND AUTOPHAGY REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22727">
        <property type="entry name" value="PROTEIN CBG13728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23089">
        <property type="entry name" value="ELAPOR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23031">
        <property type="entry name" value="GBD_ELAPOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23032">
        <property type="entry name" value="GBD_ELAPOR1-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23087">
        <property type="entry name" value="MRH_ELAPOR1_9th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23091">
        <property type="entry name" value="TNFR_ELAPOR1_6th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0732">Signal</keyword>
    <keyword evidence="7 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149965" description="Endosome/lysosome-associated apoptosis and autophagy regulator 1" evidence="24">
        <location>
            <begin position="42"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="907"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="25">
        <location>
            <begin position="656"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="992"/>
            <end position="1013"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00037817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00064532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00070074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014765.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111415" checksum="099C94D6CCE5E982" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V411</accession>
    <name>A0A8C5V411_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (32-2'-O)-methyltransferase regulator THADA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">THADA</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011835">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011836">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000010397.3">
        <property type="protein sequence ID" value="ENSMICP00000009468.3"/>
        <property type="gene ID" value="ENSMICG00000010352.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015500"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032471">
        <property type="term" value="P:negative regulation of endoplasmic reticulum calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF7">
        <property type="entry name" value="THYROID ADENOMA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="7">
        <location>
            <begin position="522"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="6">
        <location>
            <begin position="948"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="8">
        <location>
            <begin position="1250"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="890"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009468.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1952" mass="219105" checksum="3FDC9501D9C76D0A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V466</accession>
    <name>A0A8C5V466_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">URB1 ribosome biosis homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">URB1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03033105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033106">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140301.1">
        <property type="nucleotide sequence ID" value="XM_020284712.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000016441.3">
        <property type="protein sequence ID" value="ENSMICP00000014985.3"/>
        <property type="gene ID" value="ENSMICG00000016424.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880080"/>
    <dbReference type="CTD" id="9875"/>
    <dbReference type="GeneTree" id="ENSGT00390000014210"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="75"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="632"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="1663"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2016"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2022"/>
            <end position="2031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014985.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2266" mass="253310" checksum="916228BF043F4069" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6N5</accession>
    <name>A0A8C5V6N5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Long-chain-fatty-acid--CoA ligase ACSBG2</fullName>
            <ecNumber evidence="10">6.2.1.15</ecNumber>
            <ecNumber evidence="11">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Acyl-CoA synthetase bubblegum family member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Arachidonate--CoA ligase ACSBG2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACSBG2</name>
        <name evidence="21" type="synonym">LOC105869659</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33607"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33608"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33651"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57383"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:33652"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:30751"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30752"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the ATP-dependent AMP-binding enzyme family. Bubblegum subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="10"/>
    <dbReference type="EC" id="6.2.1.3" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03028083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6N5"/>
    <dbReference type="Ensembl" id="ENSMICT00000014479.3">
        <property type="protein sequence ID" value="ENSMICP00000013196.3"/>
        <property type="gene ID" value="ENSMICG00000014476.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155332"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05933">
        <property type="entry name" value="ACSBG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF101">
        <property type="entry name" value="ACYL-COA SYNTHETASE BUBBLEGUM FAMILY MEMBER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="20">
        <location>
            <begin position="58"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00042118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013196.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="667" mass="74771" checksum="8B8A2406DEE7B5A5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7H0</accession>
    <name>A0A8C5V7H0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regucalcin</fullName>
            <ecNumber evidence="7">3.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Gluconolactonase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Senescence marker protein 30</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RGN</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucono-1,5-lactone + H2O = D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="EC" id="3.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SMP-30/CGR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.17" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03036527">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7H0"/>
    <dbReference type="Ensembl" id="ENSMICT00000016924.3">
        <property type="protein sequence ID" value="ENSMICP00000015424.2"/>
        <property type="gene ID" value="ENSMICG00000016929.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014995"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004341">
        <property type="term" value="F:gluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008367">
        <property type="entry name" value="Regucalcin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005511">
        <property type="entry name" value="SMP-30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10907:SF54">
        <property type="entry name" value="REGUCALCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01791">
        <property type="entry name" value="REGUCALCIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01790">
        <property type="entry name" value="SMP30FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="17">
        <location>
            <begin position="16"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="17">
        <location>
            <begin position="116"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="15">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR605511-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015424.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="227" mass="24982" checksum="51F32AC75B82AB67" modified="2022-01-19" version="1">MSSIKIECVLPENCRCGESPVWEEASNSLLFVDIPARKICRWNPLTNQLQRVTADAPVSSVALRQSGGYVATIGTKFCALNWEDQSIVALATVDKDKKNNRFNDGKVDPAGRYFAANRRSVYKLEKEEQIPDGMCIDAEGKLWVACYNGGRVIRLDPETGKRLQTVKLPVDKTTSCCFGGKDYSEMYVTCARDGLDSENLLRQPEAGGIFKITGLGVKGIAPYPYAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9M7</accession>
    <name>A0A8C5V9M7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC105856979</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="17">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="17">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010921">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000027100.2">
        <property type="protein sequence ID" value="ENSMICP00000017967.2"/>
        <property type="gene ID" value="ENSMICG00000027664.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183114"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.50:FF:000001">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000025">
        <property type="entry name" value="Aldehyde oxidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.50:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014313">
        <property type="entry name" value="Aldehyde_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02969">
        <property type="entry name" value="mam_aldehyde_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="18">
        <location>
            <begin position="246"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="274"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="782"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="813"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="927"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1094"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017967.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1344" mass="149074" checksum="D493213D1509FB16" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VA10</accession>
    <name>A0A8C5VA10_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">General transcription factor IIH subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105881469</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016064">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016065">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VA10"/>
    <dbReference type="Ensembl" id="ENSMICT00000040314.2">
        <property type="protein sequence ID" value="ENSMICP00000018746.1"/>
        <property type="gene ID" value="ENSMICG00000037919.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00490000043395"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01453">
        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000282">
        <property type="entry name" value="General transcription factor IIH subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="60"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="377" mass="42255" checksum="97FD44C544C12BB5" modified="2022-01-19" version="1">MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHIASLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGVLGSSSPPASASQSVRITGFPQHTIASLSDQDAKPSFSMAHLDSNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYICTVCQNVFCVDCDVFVHDSLHCCPGCIHKIPSHSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VB55</accession>
    <name>A0A8C5VB55_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZDHHC2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03023760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VB55"/>
    <dbReference type="Ensembl" id="ENSMICT00000017836.3">
        <property type="protein sequence ID" value="ENSMICP00000016245.3"/>
        <property type="gene ID" value="ENSMICG00000017836.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153716"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019705">
        <property type="term" value="F:protein-cysteine S-myristoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140439">
        <property type="term" value="F:protein-cysteine S-stearoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099630">
        <property type="term" value="P:postsynaptic neurotransmitter receptor cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903044">
        <property type="term" value="P:protein localization to membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022407">
        <property type="term" value="P:regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="125"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016245.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="368" mass="42026" checksum="11B11DE3B224B826" modified="2022-01-19" version="1">MAPSGPGSARRRCRRVLYWIPVVFICLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYAEKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCQLIKPDRCHHCSNLLLLKYLHAGGLFYSVVNNCVGFSNYKFFLLFLAYSLLYCVFIAATDLQYFVKFWTNGLPDTQAKFHIMFLFFAAAMFSVSLSSLFGYHCWLVSKNKSTLEAFRSPVFRHGTDKNGFSLGFSKNMRQVFGDEKKYWLLPIFSSLGDGCSFPTCLVNQDPEQPSTPAGLNSTAKNPENHQFPAKPLRESQSHLLTDSQSWTESSTNPGKCKAGMSNPALTMENET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBU4</accession>
    <name>A0A8C5VBU4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 221 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM221B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM221 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBU4"/>
    <dbReference type="Ensembl" id="ENSMICT00000042790.2">
        <property type="protein sequence ID" value="ENSMICP00000017205.1"/>
        <property type="gene ID" value="ENSMICG00000036610.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00770000120611"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026755">
        <property type="entry name" value="Fam221a/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214">
        <property type="entry name" value="PROTEIN FAM221A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31214:SF3">
        <property type="entry name" value="PROTEIN FAM221B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14753">
        <property type="entry name" value="FAM221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="414" mass="46547" checksum="4E86485649C0885D" modified="2022-01-19" version="1">MEADEVTEEPHTTMDAEEHPSSKNPSAEDLQKDPISETFLEPSISETPLEPHMSESPLSPLVPSPSQTPLGTHTSETHLEPSNSKTSLEYSISGIPLETPTSEGPLDSHISVVPEKHLDIHLPSAGPVPVSSSDALREDLSPEASSNKVSWPRESTQVSESESSPKDSLPGPSTQVYMNISENQEEEAREDEEGVDASDSPTHTAHPGHQLGYTVRPGVPAKQAELVAVAKAMHRKEFNAQMNHLFQWENNAALNAIQTGLYIGWRCPHYLWDCFRIGDESKCFCGHLLREHKIISDISVPCNVSQCRCLMFCFIPSRPEEVGEFWLRRRATFDPKAWRAQCRCKHSHEEHSATGSHPCRHHGCCCRYFESNFLCVACDRRWEEHETFFETEETRRRGGRPHGTDTVNNWRRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBV7</accession>
    <name>A0A8C5VBV7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit DKC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dyskerin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Nopp140-associated protein of 57 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein NAP57</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nucleolar protein family A member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">snoRNP protein DKC1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105864333</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBV7"/>
    <dbReference type="SMR" id="A0A8C5VBV7"/>
    <dbReference type="Ensembl" id="ENSMICT00000046573.2">
        <property type="protein sequence ID" value="ENSMICP00000016664.1"/>
        <property type="gene ID" value="ENSMICG00000038751.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047092"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="14">
        <location>
            <begin position="48"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="13">
        <location>
            <begin position="297"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="519" mass="58208" checksum="E3D4A654C07B177B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VG58</accession>
    <name>A0A8C5VG58_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105884136</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VG58"/>
    <dbReference type="Ensembl" id="ENSMICT00000052302.2">
        <property type="protein sequence ID" value="ENSMICP00000019734.1"/>
        <property type="gene ID" value="ENSMICG00000036331.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018706"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="241" mass="28061" checksum="B51E7C13E26FD8EA" modified="2022-01-19" version="1">MPQNEYIKLHRKRYGYRLDYHEKKRKKESQEAHERSKKAKKVIGLKAKLYHKQRHAEKIQMKKAIKMHEKRNTKQKNDEKTPQGAVPAYLLDREGQSRVKVVSNMIKQKRKEKAGKWGVPLPKVRAQAETEVLKVIRTGKRKKKAWKRMVPKVCFVGDDFTRKQPKYVRFIRSMGLRFKKAHVTHPELKATFCLPVLGTVIKVNVSELGLVTQGGKVIWGNYVQVTSNPENDRCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJE7</accession>
    <name>A0A8C5VJE7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PAK6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03004594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621851.1">
        <property type="nucleotide sequence ID" value="XM_012766397.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJE7"/>
    <dbReference type="Ensembl" id="ENSMICT00000029329.2">
        <property type="protein sequence ID" value="ENSMICP00000022248.1"/>
        <property type="gene ID" value="ENSMICG00000007683.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872431"/>
    <dbReference type="KEGG" id="mmur:105872431"/>
    <dbReference type="CTD" id="56924"/>
    <dbReference type="GeneTree" id="ENSGT00940000156528"/>
    <dbReference type="OrthoDB" id="1022360at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007612">
        <property type="term" value="P:learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140058">
        <property type="term" value="P:neuron projection arborization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990138">
        <property type="term" value="P:neuron projection extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06659">
        <property type="entry name" value="STKc_PAK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000073">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035066">
        <property type="entry name" value="STKc_PAK6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF3">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="407"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="99"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="199"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="268"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="681" mass="74782" checksum="BC8C4093E497E8DD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VK82</accession>
    <name>A0A8C5VK82_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LY6/PLAUR domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LYPD1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595517.1">
        <property type="nucleotide sequence ID" value="XM_012740063.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VK82"/>
    <dbReference type="Ensembl" id="ENSMICT00000040409.2">
        <property type="protein sequence ID" value="ENSMICP00000024657.1"/>
        <property type="gene ID" value="ENSMICG00000029863.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105857607"/>
    <dbReference type="KEGG" id="mmur:105857607"/>
    <dbReference type="CTD" id="116372"/>
    <dbReference type="GeneTree" id="ENSGT00390000002215"/>
    <dbReference type="OrthoDB" id="9924997at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030550">
        <property type="term" value="F:acetylcholine receptor inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0095500">
        <property type="term" value="P:acetylcholine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23559">
        <property type="entry name" value="TFP_LU_ECD_LYPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036">
        <property type="entry name" value="CD59 GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10036:SF7">
        <property type="entry name" value="LY6_PLAUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150084" evidence="5">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="6">
        <location>
            <begin position="22"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="141" mass="15159" checksum="1946D13C51A6E2E4" modified="2022-01-19" version="1">MWVLGIAATFCGLFLIPGFALQIQCYQCEEFQLNNDCSSPEFIVNCTVNVQDMCQKEVMEQSAGIMYRKSCASSAACLIASAGYQSFCSPGKLNSVCISCCNTPLCNGPRPKKRGSSASALRPGLPTTVLLLKLALFLAHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLV7</accession>
    <name>A0A8C5VLV7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane integral NOTCH2 associated receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MINAR2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINAR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016679">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLV7"/>
    <dbReference type="Ensembl" id="ENSMICT00000031732.2">
        <property type="protein sequence ID" value="ENSMICP00000025645.1"/>
        <property type="gene ID" value="ENSMICG00000027569.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063851"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032420">
        <property type="term" value="C:stereocilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035640">
        <property type="term" value="P:exploration behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042491">
        <property type="term" value="P:inner ear auditory receptor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060122">
        <property type="term" value="P:inner ear receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090659">
        <property type="term" value="P:walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039706">
        <property type="entry name" value="MINAR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009626">
        <property type="entry name" value="MINAR1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530:SF4">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06789">
        <property type="entry name" value="MINAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Major intrinsically disordered Notch2-binding receptor 1-like C-terminal" evidence="8">
        <location>
            <begin position="46"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="189" mass="21070" checksum="AB38822DB3FF3941" modified="2022-01-19" version="1">MDLSVLPNNNHPDKFLQLDVKSLMSSALLQASLAQFPGGNYPAAQHWQNLVYSQREKKNTAAQRPRGSGAECLAAAGSPPSSALSVTKNNPLYGDVSLEEAMEERKKSPSWTIEDYDKRSLHTNLSGHLKENPNDLRFWLGDMYTPGFDTLLKKEKKQEKQSKLCRLGLIFFVLTSIVVTIVTISTLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VN09</accession>
    <name>A0A8C5VN09_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rho-related GTP-binding protein RhoH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RHOH</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023149">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VN09"/>
    <dbReference type="Ensembl" id="ENSMICT00000034885.2">
        <property type="protein sequence ID" value="ENSMICP00000025575.2"/>
        <property type="gene ID" value="ENSMICG00000027779.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160078"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00157">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000756">
        <property type="entry name" value="Rho-related GTP-binding protein RhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025575.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="187" mass="20768" checksum="FBBFFECEDCE9146F" modified="2022-01-19" version="1">MLSSIKCVLVGDSAVGKTSLLVRFTSETFPEAYKPTVYENTGVDVFMDGVQISLGLWDTAGNDAFRSIRPLSYQQADVVLMCYSVANQSSFLNLKNKWIGEIRSNLPCTPVLVVATQTDQREMGPHRATCVSAIDGKRLAQDVRAKGYLECSALSNRGVQQVFECAVRTAVNQARRRNRRRLFPVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNY4</accession>
    <name>A0A8C5VNY4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HBS1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">HBS1L</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the Pelota-HBS1L complex, also named Dom34-Hbs1 complex, composed of PELO and HBS1L. Interacts with the SKI complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008441">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNY4"/>
    <dbReference type="Ensembl" id="ENSMICT00000044948.2">
        <property type="protein sequence ID" value="ENSMICP00000026938.2"/>
        <property type="gene ID" value="ENSMICG00000001533.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156274"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000039">
        <property type="entry name" value="HBS1-like translational GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000035">
        <property type="entry name" value="HBS1-like translational GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037189">
        <property type="entry name" value="HBS1-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109732">
        <property type="entry name" value="HBS1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="241"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026938.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="663" mass="73358" checksum="781964D40B46A60E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYG3</accession>
    <name>A0A8C5VYG3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat and fibronectin type III domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ANKFN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May play a role in neuronal function.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03020057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020058">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000052714.2">
        <property type="protein sequence ID" value="ENSMICP00000028754.2"/>
        <property type="gene ID" value="ENSMICG00000003923.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159856"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050957">
        <property type="term" value="P:equilibrioception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045475">
        <property type="term" value="P:locomotor rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061172">
        <property type="term" value="P:regulation of establishment of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000296">
        <property type="entry name" value="Ankyrin repeat and fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000905">
        <property type="entry name" value="Ankyrin repeat and fibronectin type III domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039269">
        <property type="entry name" value="ANKFN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437:SF3">
        <property type="entry name" value="ANKYRIN REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21437">
        <property type="entry name" value="WIDE AWAKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="273"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="861"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1048"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1106"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028754.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1150" mass="129991" checksum="29C5E65510DC2B5E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYG6</accession>
    <name>A0A8C5VYG6_MICMU</name>
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        <recommendedName>
            <fullName evidence="9">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
            <ecNumber evidence="8">3.5.99.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Translation inhibitor L-PSP ribonuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:39975"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:76545"/>
            <dbReference type="EC" id="3.5.99.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-iminopropanoate + H2O = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:40671"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:44400"/>
            <dbReference type="EC" id="3.5.99.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotrimer. Interacts with YTHDF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.10" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03023243">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYG6"/>
    <dbReference type="Ensembl" id="ENSMICT00000035548.2">
        <property type="protein sequence ID" value="ENSMICP00000032988.1"/>
        <property type="gene ID" value="ENSMICG00000028777.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029792"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120241">
        <property type="term" value="F:2-iminobutanoate/2-iminopropanoate deaminase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF53">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="125" mass="13370" checksum="C2B3A7C73F91025B" modified="2022-01-19" version="1">MSSLIRSMISTAKALGATGPYSQAVLVDKTVYISGQIEVEAAAKQALKNMGEILKAPGCDFTNVVKTTVLLADINDFNTVNDIYKQYFKSNFPARAAYQVAALPKGGRIEIEAVAVQGPFTTPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYN8</accession>
    <name>A0A8C5VYN8_MICMU</name>
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        <submittedName>
            <fullName evidence="9">G protein-coupled receptor 162</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="primary">GPR162</name>
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    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
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                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Shelton J."/>
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                <person name="Durand N."/>
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                <person name="Worley K.C."/>
                <person name="Rogers J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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</entry>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
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                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
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                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Durand N."/>
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                <person name="Worley K.C."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="264"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="532"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="67696" checksum="AD0822D00D763ED7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W542</accession>
    <name>A0A8C5W542_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Amyloid beta like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">APLP1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the APP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630434.1">
        <property type="nucleotide sequence ID" value="XM_012774980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W542"/>
    <dbReference type="Ensembl" id="ENSMICT00000037910.2">
        <property type="protein sequence ID" value="ENSMICP00000035257.1"/>
        <property type="gene ID" value="ENSMICG00000010113.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876901"/>
    <dbReference type="KEGG" id="mmur:105876901"/>
    <dbReference type="CTD" id="333"/>
    <dbReference type="GeneTree" id="ENSGT00530000063252"/>
    <dbReference type="OrthoDB" id="6147836at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031694">
        <property type="term" value="F:alpha-2A adrenergic receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031695">
        <property type="term" value="F:alpha-2B adrenergic receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031696">
        <property type="term" value="F:alpha-2C adrenergic receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071874">
        <property type="term" value="P:cellular response to norepinephrine stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180011">
        <property type="term" value="P:cytosolic mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106072">
        <property type="term" value="P:negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21708">
        <property type="entry name" value="JMTM_APLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.770:FF:000001">
        <property type="entry name" value="Amyloid beta A4 protein-like isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.770">
        <property type="entry name" value="Amyloid precursor protein, E2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.140">
        <property type="entry name" value="Amyloidogenic glycoprotein, copper-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.570.10">
        <property type="entry name" value="Amyloidogenic glycoprotein, heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036669">
        <property type="entry name" value="Amyloid_Cu-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008155">
        <property type="entry name" value="Amyloid_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011178">
        <property type="entry name" value="Amyloid_glyco_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024329">
        <property type="entry name" value="Amyloid_glyco_E2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008154">
        <property type="entry name" value="Amyloid_glyco_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015849">
        <property type="entry name" value="Amyloid_glyco_heparin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036454">
        <property type="entry name" value="Amyloid_glyco_heparin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019745">
        <property type="entry name" value="Amyloid_glyco_intracell_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019543">
        <property type="entry name" value="APP_amyloid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019744">
        <property type="entry name" value="APP_CUBD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036176">
        <property type="entry name" value="E2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103">
        <property type="entry name" value="ALZHEIMER'S DISEASE BETA-AMYLOID RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23103:SF13">
        <property type="entry name" value="AMYLOID BETA PRECURSOR LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10515">
        <property type="entry name" value="APP_amyloid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12924">
        <property type="entry name" value="APP_Cu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12925">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02177">
        <property type="entry name" value="APP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00203">
        <property type="entry name" value="AMYLOIDA4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00006">
        <property type="entry name" value="A4_EXTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56491">
        <property type="entry name" value="A heparin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89811">
        <property type="entry name" value="Amyloid beta a4 protein copper binding domain (domain 2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109843">
        <property type="entry name" value="CAPPD, an extracellular domain of amyloid beta A4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00319">
        <property type="entry name" value="APP_CUBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51869">
        <property type="entry name" value="APP_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51870">
        <property type="entry name" value="APP_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00320">
        <property type="entry name" value="APP_INTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150224" evidence="13">
        <location>
            <begin position="39"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="580"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="E1" evidence="14">
        <location>
            <begin position="50"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="E2" evidence="15">
        <location>
            <begin position="295"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="GFLD subdomain" evidence="10">
        <location>
            <begin position="50"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="CuBD subdomain" evidence="10">
        <location>
            <begin position="154"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="493"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="649" mass="72149" checksum="02D363A2C87909F6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W5R4</accession>
    <name>A0A8C5W5R4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Photoreceptor-specific nuclear receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Nuclear receptor subfamily 2 group E member 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Retina-specific nuclear receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NR2E3</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Orphan nuclear receptor of retinal photoreceptor cells. Transcriptional factor that is an activator of rod development and repressor of cone development. Binds the promoter region of a number of rod- and cone-specific genes, including rhodopsin, M- and S-opsin and rod-specific phosphodiesterase beta subunit. Enhances rhodopsin expression. Represses M- and S-cone opsin expression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004868">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5R4"/>
    <dbReference type="Ensembl" id="ENSMICT00000047551.2">
        <property type="protein sequence ID" value="ENSMICP00000034380.2"/>
        <property type="gene ID" value="ENSMICG00000038667.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156926"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042462">
        <property type="term" value="P:eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06970">
        <property type="entry name" value="NR_DBD_PNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06950">
        <property type="entry name" value="NR_LBD_Tlx_PNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.565.10:FF:000022">
        <property type="entry name" value="Nuclear receptor subfamily 2 group E member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000028">
        <property type="entry name" value="Nuclear receptor subfamily 2, group E, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.565.10">
        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035500">
        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001723">
        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="6 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="19">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="20">
        <location>
            <begin position="169"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="117"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034380.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="410" mass="44508" checksum="C70C0876A0EE99A9" modified="2022-01-19" version="1">PRTRPTAPMSSSVAAAAPAAGAASRKESPGRWGLGEDAAGAGPALQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESDTEPRPQPLVAPPAPAGPSPRGPTPVSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFTAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLAAIQWSLPLDGCPLLPPPEASAAGGAQGRLPLASMETRVLRETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITSERIEFLFFRKTIGNTPMEKLLCDMFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W9E1</accession>
    <name>A0A8C5W9E1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005457">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W9E1"/>
    <dbReference type="Ensembl" id="ENSMICT00000041802.2">
        <property type="protein sequence ID" value="ENSMICP00000036126.1"/>
        <property type="gene ID" value="ENSMICG00000027479.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012569"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF7">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="24067" checksum="F3B1434F24CC8D80" modified="2022-01-19" version="1">MAASGESGTSGGRGSTEKALTTLYSEVKQIKKRDSVLTSKNQIKRLTRPDPEVTDKEIKKRCWQLSILVHPDKNQDDAGRATVDKVDKLLLDQAQKKKALNVIQAGKEYVEHTDYPELFKQAVYKQTMKLSAELEIERKEKAKEMHKRKQQRKEEIEAEEKWQKNFEESRDVHVDSWQNFQANTKGKKEKKNQTILRPPKVKMEQPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEA8</accession>
    <name>A0A8C5XEA8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DMRT like family B with proline rich C-terminal 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">DMRTB1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRT family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001460">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEA8"/>
    <dbReference type="Ensembl" id="ENSMICT00000014234.3">
        <property type="protein sequence ID" value="ENSMICP00000012976.2"/>
        <property type="gene ID" value="ENSMICG00000014235.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161912"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007548">
        <property type="term" value="P:sex differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1040.10">
        <property type="entry name" value="DM DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001275">
        <property type="entry name" value="DM_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036407">
        <property type="entry name" value="DM_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026607">
        <property type="entry name" value="DMRT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322">
        <property type="entry name" value="DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12322:SF66">
        <property type="entry name" value="DOUBLESEX- AND MAB-3-RELATED TRANSCRIPTION FACTOR B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00751">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00301">
        <property type="entry name" value="DM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82927">
        <property type="entry name" value="Cysteine-rich DNA binding domain, (DM domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS40000">
        <property type="entry name" value="DM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50809">
        <property type="entry name" value="DM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DM" evidence="8">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="DM" evidence="6">
        <location>
            <begin position="11"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012976.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="316" mass="33624" checksum="657E3B90629CA43E" modified="2025-10-08" version="2">MADKMLRTPKCSRCRNHGFLVPVKGHAGKCRWKQCICEKCYLITERQKIMAAQKMLKRQASEEEDEVTLGAQGLELASGAAAAGPGASLRPLPPLAASRDAERPPRGPSPGPSAFQPVLGGRGHVGPSERAALAMPYPLGPQLGAEAAGSGGYGRLELRRPLRPMPSPPFADFGPPLSINSDCLYPMHPYRPFPLGYQDAPPAPGIPLQPGFRHVSCSPYHGGGLVSEPVGDFQPSYYPPPPLPPPPPPPPTPLQPQFLPPGFLSALHLLPPPPPPPPPSSFSLTILSDTDKENTDDQDAEVLGEPSQPSSQEQSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XH55</accession>
    <name>A0A8C5XH55_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heat shock factor-binding protein 1-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HSBP1L1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022791">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XH55"/>
    <dbReference type="Ensembl" id="ENSMICT00000048897.2">
        <property type="protein sequence ID" value="ENSMICP00000021962.2"/>
        <property type="gene ID" value="ENSMICG00000028958.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000076117"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.430:FF:000004">
        <property type="entry name" value="heat shock factor-binding protein 1-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF4">
        <property type="entry name" value="HEAT SHOCK FACTOR-BINDING PROTEIN 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00067977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021962.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="74" mass="8290" checksum="E44386935CEBE690" modified="2022-01-19" version="1">MDTRGPETPGGAVLRDAAENLIQELQEHFQALTATLTIRMEEMGHRIEDLQKNVNDLMVQAGIENSIKEQMLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XMM3</accession>
    <name>A0A8C5XMM3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome activator complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Proteasome activator PA200</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Protein BLM10 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PSME4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with the 20S and 26S proteasomes. Component of the spermatoproteasome, a form of the proteasome specifically found in testis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BLM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005010">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633245.1">
        <property type="nucleotide sequence ID" value="XM_012777791.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000054595.2">
        <property type="protein sequence ID" value="ENSMICP00000037766.1"/>
        <property type="gene ID" value="ENSMICG00000017158.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878408"/>
    <dbReference type="CTD" id="23198"/>
    <dbReference type="GeneTree" id="ENSGT00390000011433"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990111">
        <property type="term" value="C:spermatoproteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035092">
        <property type="term" value="P:sperm DNA condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000183">
        <property type="entry name" value="Proteasome activator complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055455">
        <property type="entry name" value="HEAT_PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23096">
        <property type="entry name" value="HEAT_PSME4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="17">
        <location>
            <begin position="330"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4-like HEAT repeat-like" evidence="18">
        <location>
            <begin position="1185"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="16">
        <location>
            <begin position="1757"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1843" mass="211309" checksum="92B0A7FD3292DEE7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XPJ1</accession>
    <name>A0A8C5XPJ1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serpin family A member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SERPINA3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003500">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003502">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003506">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003509">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XPJ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000031973.2">
        <property type="protein sequence ID" value="ENSMICP00000039022.2"/>
        <property type="gene ID" value="ENSMICG00000029260.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154392"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19551">
        <property type="entry name" value="serpinA3_A1AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000001">
        <property type="entry name" value="Serine protease inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000002">
        <property type="entry name" value="Serpin family D member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF145">
        <property type="entry name" value="ALPHA-1-ANTICHYMOTRYPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034044409" evidence="3">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Serpin" evidence="4">
        <location>
            <begin position="56"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039022.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="421" mass="46671" checksum="91D78EE57AF56BAE" modified="2022-01-19" version="1">MFPLLALGLLVAGICPAVLCHPGGPRDQESVTLGDHDNGTRGDSLRLGSSDTDFAFGLYKQLALQNPNENVIFSPLSVSAALAFLSLGAGGTTLTELLQGLKFNLTETSEAEIHQSFQQLLRSLSRPSEQLQLSTGNAMFIAEQLRLRERFVEDARGLYASKAFKTNFQDSAAAEKFINDYVEKKTRGKIVDLVKDLDPSTMMVLVNYIFFKAKWKTPFDPHDTVKARFYLSRRKWVKVPMMSMEDLDVPYFRDEELSCAVAELMYTGNASALLVLPDLGKMKQVEAKLLPETLRRWRDSLQTRHIDSLQLPKFSISGDYNLENILPRLGIRAVFTKEADLSGITGAKNLVLSQMVHKAALDVAEVGTEAAAATGIKIIPMSGRMGPMFTLKFSRPFLVIIQDKALQGILFMAKVTELKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQ85</accession>
    <name>A0A8C5XQ85_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQ85"/>
    <dbReference type="Ensembl" id="ENSMICT00000032518.2">
        <property type="protein sequence ID" value="ENSMICP00000039512.2"/>
        <property type="gene ID" value="ENSMICG00000036638.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155458"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000007">
        <property type="entry name" value="Putative myosin regulatory light chain sqh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039512.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="205" mass="22701" checksum="0B48283A33BAFE59" modified="2022-01-19" version="1">DLTAGMSSKRAKTKTTKKRPQGTTSNVFAMFDQSQIQEFKEAFDMTDQSRDGLIDKEDLHDVLASLGKNPTDEYLETTMKEAPGPTSLTTFLAVFGEKLNGADPEDVIRNAFACFDEEATGAIREDHLRELEAPTDKKGNFNCIGFTRTLKHGARDKDDRRELQIRPGAVAHACNPSTLGGRGGRIARGQEFETSLSETPRLYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XW13</accession>
    <name>A0A8C5XW13_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rho guanine nucleotide exchange factor 19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ARHGEF19</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03002300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618525.1">
        <property type="nucleotide sequence ID" value="XM_012763071.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618526.1">
        <property type="nucleotide sequence ID" value="XM_012763072.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618527.1">
        <property type="nucleotide sequence ID" value="XM_012763073.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XW13"/>
    <dbReference type="Ensembl" id="ENSMICT00000059012.1">
        <property type="protein sequence ID" value="ENSMICP00000041994.1"/>
        <property type="gene ID" value="ENSMICG00000042882.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870458"/>
    <dbReference type="KEGG" id="mmur:105870458"/>
    <dbReference type="CTD" id="128272"/>
    <dbReference type="GeneTree" id="ENSGT01030000234571"/>
    <dbReference type="OrthoDB" id="27593at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01221">
        <property type="entry name" value="PH_ephexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000205">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000111">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000007">
        <property type="entry name" value="rho guanine nucleotide exchange factor 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047271">
        <property type="entry name" value="Ephexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047270">
        <property type="entry name" value="PH_ephexin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12845:SF6">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="DH" evidence="7">
        <location>
            <begin position="382"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="598"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="721"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="214"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="808" mass="89448" checksum="EF6231C32C953FAC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYH0</accession>
    <name>A0A8C5XYH0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP-ribosylation factor-like protein 5A</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035916">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYH0"/>
    <dbReference type="Ensembl" id="ENSMICT00000058334.1">
        <property type="protein sequence ID" value="ENSMICP00000043170.1"/>
        <property type="gene ID" value="ENSMICG00000046220.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154714"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903292">
        <property type="term" value="P:protein localization to Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04153">
        <property type="entry name" value="Arl5_Arl8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000294">
        <property type="entry name" value="ADP-ribosylation factor-like protein 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20875" checksum="65B46784C09F3367" modified="2022-01-19" version="1">ITGILFTRIWRLFNHQEHKVNIIGLANAGKTTILYQFSMNEVVHTSPTIGSNVEEIVINNTRFLMWDIGGQECLHSSWNTYYTNTEFVIVVVDSIDRERISVTREELYKMLAHEDLRKAELLIFVNKQDVKESMTVAEISQFLKLTSIKDHQWHIQACCALTGEGLCQGLEWMMSRLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYP8</accession>
    <name>A0A8C5XYP8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">KN motif and ankyrin repeat domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">KANK2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
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                <person name="Durand N."/>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
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                <person name="Doddapaneni H."/>
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                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
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                <person name="Jayaseelan J."/>
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                <person name="Khan Z."/>
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                <person name="Lee S."/>
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                <person name="Narasimhan A."/>
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                <person name="Nguyen L."/>
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    <dbReference type="Pfam" id="PF03172">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01342">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00258">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51414">
        <property type="entry name" value="HSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50864">
        <property type="entry name" value="SAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HSR" evidence="13">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="SAND" evidence="12">
        <location>
            <begin position="544"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="651"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="756"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="828" mass="94110" checksum="E69D23FC0054C1E2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1D7</accession>
    <name>A0A8C5Y1D7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MGAT4 conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 54 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029854">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y1D7"/>
    <dbReference type="Ensembl" id="ENSMICT00000064596.1">
        <property type="protein sequence ID" value="ENSMICP00000044691.1"/>
        <property type="gene ID" value="ENSMICG00000045794.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163962"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF30">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="MGAT4 conserved region" evidence="5">
        <location>
            <begin position="15"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="453" mass="51591" checksum="FB0D9394C65E2F8B" modified="2022-01-19" version="1">MVAWQRARMQTSFVRTSHLKTFKTMQRNSELLKNVSSRILIGALPMEKKLLTIGISSAWHPRGSSHLLDTLQSLFSASSPAERRHSIVLVQLADPDPRWLDEMISNISTLFKSYVQARQLVVITTPLNRYLPLKGLTKHFNDTPAYVVLRSKQNMNYAFLMNFATNHSDYFLTMEDDVKCAPGFVTQIASILSAWEREPWVTLEFCQLGFTGKLFRTRDLSGFVRFLLLFYQEMPCNNLLSHFRDILRQKKAIRFFPFLFQHMGKYSPFGGRFDMLKGEEFKENDTGSPSNPAATLYTDLNATDGSVLMNAYSLDESFFYTKEATAGSHLTVLLNIPAVVFRVQVLTGSELKKENQLEEGQVELGYDSTNRINDCDDYILLGLLINGILDKHVLSEESGKKVKCVRVVVTAPLPSGLIVRHINLWIKETEKYTQKPLEVLGVVRLESTEVTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1N7</accession>
    <name>A0A8C5Y1N7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epididymal sperm binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ELSPBP1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the seminal plasma protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026783">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026784">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y1N7"/>
    <dbReference type="Ensembl" id="ENSMICT00000069102.1">
        <property type="protein sequence ID" value="ENSMICP00000044835.1"/>
        <property type="gene ID" value="ENSMICG00000007142.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162766"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048240">
        <property type="term" value="P:sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000008">
        <property type="entry name" value="Epididymal sperm-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051666">
        <property type="entry name" value="SP_Capacitation_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918:SF2">
        <property type="entry name" value="EPIDIDYMAL SPERM-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22918">
        <property type="entry name" value="SEMINAL PLASMA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034120794" evidence="7">
        <location>
            <begin position="24"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-II" evidence="8">
        <location>
            <begin position="29"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="75" mass="8876" checksum="43802FC07A76F8E6" modified="2022-01-19" version="1">MNGWSSYLLGWTTFLLYSYETQGRISSLAPGFPCHFPFNYKNKNYYNCTNKGSKENLTWCATSYNFDQDHTWVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4L2</accession>
    <name>A0A8C5Y4L2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Centrosomal protein 170B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CEP170B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEP170 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003728">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000045805.1"/>
        <property type="gene ID" value="ENSMICG00000035450.2"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
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        <property type="entry name" value="CEP170_C"/>
    </dbReference>
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        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF18">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15308">
        <property type="entry name" value="CEP170_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="793"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1051"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1468"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1644"/>
            <end position="1674"/>
        </location>
    </feature>
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        <location>
            <begin position="269"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="452"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="552"/>
            <end position="568"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1402"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1484"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1709" mass="183317" checksum="43E0258BB9B4736A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y5J1</accession>
    <name>A0A8C5Y5J1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002989">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y5J1"/>
    <dbReference type="Ensembl" id="ENSMICT00000032756.2">
        <property type="protein sequence ID" value="ENSMICP00000045778.1"/>
        <property type="gene ID" value="ENSMICG00000034737.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01090000260040"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00244">
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    </dbReference>
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        <property type="entry name" value="1433ZETA"/>
    </dbReference>
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        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="125" mass="14046" checksum="07BFF6A76055E6F5" modified="2022-01-19" version="1">MKGDYFRYLAEIACGDDRKQTIDNSLGDYQEAFDISKKEMQPTHPIPLGLALNFSVFYYEILNNPELACTLAKMAFDEAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDSAGEECDAAEGAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y696</accession>
    <name>A0A8C5Y696_MICMU</name>
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        <recommendedName>
            <fullName evidence="2">MAGE domain-containing protein</fullName>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03035161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y696"/>
    <dbReference type="Ensembl" id="ENSMICT00000063196.1">
        <property type="protein sequence ID" value="ENSMICP00000046448.1"/>
        <property type="gene ID" value="ENSMICG00000047372.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154972"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Melanoma-associated antigen C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1210:FF:000001">
        <property type="entry name" value="melanoma-associated antigen D1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
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        <property type="entry name" value="MAGE_N"/>
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        <property type="entry name" value="MAGE_WH1"/>
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        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR11736:SF153">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN 10"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="105"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="310" mass="34582" checksum="C562C08664848D0A" modified="2022-01-19" version="1">MPHHHDDQRNQCGSLEKGLQAQRVAQGLVGAQAPGAQEEEVATSSTVIPSILEEAGAAETPSPPGSPEGDSSSPTSLASKHHSDEGSSSEEEEGPSTYKDPEDSASKRMSDLVHFLLLKYRFKDPITKAEMLNIVLNDYQDHFPEIFMKASECMQMVFGVDVKEVDPAGHSYVLVTTLGLTYYEELNDDQRFPKSGLLIIMLGLILFEGDCAPEEVIWEALGGMGVHAGSEHYIYGEPRKLITQDWVQEGYLEYRQVPDSDPACYEFLWGPRAHAETSKMKVLEYVLKVNRSDHRSFPLLYEESVRDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7T2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018527">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="54" mass="6326" checksum="49A8859040B06EDA" modified="2022-01-19" version="1">MPAATVDHSQRICEVWACNLDEEMKKIRQVIGKYNYVAMDTDFFFIMGQKIQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y853</accession>
    <name>A0A8C5Y853_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
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        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017847">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y853"/>
    <dbReference type="Ensembl" id="ENSMICT00000059074.1">
        <property type="protein sequence ID" value="ENSMICP00000047765.1"/>
        <property type="gene ID" value="ENSMICG00000045668.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111659"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="108" mass="11039" checksum="A96BDCDED4E49629" modified="2022-01-19" version="1">MWILSNLMGTSEDGNLLSTVSPTVKALLGKAGVSPIFPFSPRSPFQPRIPRTPGSPWGPTGPASPLGPGFPMGPTGPGKPVGPKGPVWPLWPSLPGGPTSPFSPFCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YE45</accession>
    <name>A0A8C5YE45_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">G protein subunit gamma 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GNG14</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027788">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YE45"/>
    <dbReference type="Ensembl" id="ENSMICT00000065858.1">
        <property type="protein sequence ID" value="ENSMICP00000049356.1"/>
        <property type="gene ID" value="ENSMICG00000042997.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263497"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="9">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="68" mass="7348" checksum="0DD9787ACD104738" modified="2022-01-19" version="1">MSSKVAVGSDIGQARRTVEQLRMEAGIDRVKAADLLQFCTEQAKSDPFLVGIPAATNPFKEKKPCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7E9Q5</accession>
    <name>A0A8B7E9Q5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complexin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CPLX3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complexin/synaphin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590929.1">
        <property type="nucleotide sequence ID" value="XM_012735475.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7E9Q5"/>
    <dbReference type="Ensembl" id="ENSMICT00000065207.1">
        <property type="protein sequence ID" value="ENSMICP00000041949.1"/>
        <property type="gene ID" value="ENSMICG00000041612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105854862"/>
    <dbReference type="KEGG" id="mmur:105854862"/>
    <dbReference type="CTD" id="594855"/>
    <dbReference type="GeneTree" id="ENSGT00950000182938"/>
    <dbReference type="OrthoDB" id="9942329at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098684">
        <property type="term" value="C:photoreceptor ribbon synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031630">
        <property type="term" value="P:regulation of synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22809">
        <property type="entry name" value="Complexin_NTD_CPLX_III_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.580">
        <property type="entry name" value="Single Helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008849">
        <property type="entry name" value="Synaphin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705">
        <property type="entry name" value="COMPLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16705:SF5">
        <property type="entry name" value="COMPLEXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05835">
        <property type="entry name" value="Synaphin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0770">Synapse</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="158" mass="17572" checksum="05637D4A6DB6EA0F" modified="2022-01-19" version="1">MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEEKASVLGQLASLPGLDLGSLKDKAQATLGDLKQSAEKCHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EK36</accession>
    <name>A0A8B7EK36_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymocyte nuclear protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">THYN1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007182">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595065.1">
        <property type="nucleotide sequence ID" value="XM_012739611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EK36"/>
    <dbReference type="Ensembl" id="ENSMICT00000062140.1">
        <property type="protein sequence ID" value="ENSMICP00000048758.1"/>
        <property type="gene ID" value="ENSMICG00000005039.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857309"/>
    <dbReference type="KEGG" id="mmur:105857309"/>
    <dbReference type="CTD" id="29087"/>
    <dbReference type="GeneTree" id="ENSGT00390000013297"/>
    <dbReference type="OMA" id="DVQFIRM"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000003">
        <property type="entry name" value="Thymocyte nuclear protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="7">
        <location>
            <begin position="56"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="226" mass="25795" checksum="725041528D92FB07" modified="2022-01-19" version="1">MPRPQKRLAGTAGPDKKGLPGKRAKTEDAGEISAKVENSSLQKISASKDSVKKLSSYWLMKSEPESRLEKGVDVKFGIEDLKAQPKQTTCWDGVRNYQARNFLRAMKLEEAAFFYHSNCKEPGIAGLMKIVKEAYPDHTQFEKNNPHYDPSSKEDDPKWSMVDVQFVRMMKRFIPLAELKTYHQAHKATGGPLKNMTLFTRQRLSIQPLTQEEFDFILSLEEKEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EKU5</accession>
    <name>A0A8B7EKU5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein IWS1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">IWS1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">IWS1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with SUPT6H; binds preferentially to the POLR2A-bound SUPT6H. Interacts with ALYREF/THOC4, SETD2 and PRMT5. Interacts with HDGFRP2. Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011510">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011511">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011512">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595396.1">
        <property type="nucleotide sequence ID" value="XM_012739942.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EKU5"/>
    <dbReference type="Ensembl" id="ENSMICT00000040161.2">
        <property type="protein sequence ID" value="ENSMICP00000030922.2"/>
        <property type="gene ID" value="ENSMICG00000009948.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857530"/>
    <dbReference type="KEGG" id="mmur:105857530"/>
    <dbReference type="CTD" id="55677"/>
    <dbReference type="GeneTree" id="ENSGT00720000108834"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010793">
        <property type="term" value="P:regulation of mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000001">
        <property type="entry name" value="IWS1, SUPT6H interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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            <begin position="617"/>
            <end position="695"/>
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            <begin position="44"/>
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    <sequence length="822" mass="92711" checksum="C3EE9C942866F70B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EMX2</accession>
    <name>A0A8B7EMX2_MICMU</name>
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        <recommendedName>
            <fullName evidence="9">Pre-mRNA-processing-splicing factor 8</fullName>
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        <alternativeName>
            <fullName evidence="10">Splicing factor Prp8</fullName>
        </alternativeName>
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        <name evidence="12" type="primary">PRPF8</name>
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    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="8">Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.</text>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="2103"/>
            <end position="2234"/>
        </location>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009418.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2335" mass="273630" checksum="8C37AE2ABB9CB198" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQH6</accession>
    <name>A0A8B7EQH6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GDI2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">GDP-dissociation inhibitor preventing the GDP to GTP exchange of most Rab proteins. By keeping these small GTPases in their inactive GDP-bound form regulates intracellular membrane trafficking. Negatively regulates protein transport to the cilium and ciliogenesis through the inhibition of RAB8A.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with RHOH. Interacts with the GDP-bound inactive forms of RAB3A, RAB3B, RAB3C, RAB5A, RAB5B, RAB5C, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43; binds RAB3D to a lesser extent. Interacts with DZIP1; this interaction negatively regulates the interaction of GDI2 with GDP-bound RAB8A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028683">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028684">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596677.2">
        <property type="nucleotide sequence ID" value="XM_012741223.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQH6"/>
    <dbReference type="Ensembl" id="ENSMICT00000067390.1">
        <property type="protein sequence ID" value="ENSMICP00000050232.1"/>
        <property type="gene ID" value="ENSMICG00000002558.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858228"/>
    <dbReference type="KEGG" id="mmur:105858228"/>
    <dbReference type="CTD" id="2665"/>
    <dbReference type="GeneTree" id="ENSGT00950000182994"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903828">
        <property type="term" value="P:negative regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.519.10:FF:000005">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.519.10:FF:000014">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000232">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF1">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 13" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="445" mass="50445" checksum="B05A147AE4C1DF00" modified="2022-01-19" version="1">MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKLPGTPPASMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVIEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDTRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCCETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICVLSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISSAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPTDLGTESQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKNDIYGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EZR6</accession>
    <name>A0A8B7EZR6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystatin F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CST7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cystatin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021454">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600979.1">
        <property type="nucleotide sequence ID" value="XM_012745525.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EZR6"/>
    <dbReference type="Ensembl" id="ENSMICT00000002034.3">
        <property type="protein sequence ID" value="ENSMICP00000001860.2"/>
        <property type="gene ID" value="ENSMICG00000002037.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860641"/>
    <dbReference type="KEGG" id="mmur:105860641"/>
    <dbReference type="CTD" id="8530"/>
    <dbReference type="GeneTree" id="ENSGT00940000160277"/>
    <dbReference type="OrthoDB" id="9929365at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903979">
        <property type="term" value="P:negative regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031643">
        <property type="term" value="P:positive regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002577">
        <property type="term" value="P:regulation of antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000004">
        <property type="entry name" value="Cystatin C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042886">
        <property type="entry name" value="Cystatin-F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47141">
        <property type="entry name" value="CYSTATIN-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47141:SF1">
        <property type="entry name" value="CYSTATIN-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00031">
        <property type="entry name" value="Cystatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133466" evidence="3">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="4">
        <location>
            <begin position="34"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001860.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="145" mass="16444" checksum="20FD60AC4513AD24" modified="2022-01-19" version="1">MRAGALLALCCLVSSTAAVRVTPEFCSQDLNSGVKPGFPEPIKTNDPGVLKAARHSVEKFNNCTNDIFLFKESHIRRALLQIVKGLKYMLEVEIGRTTCKKNKHPNLDNCDFQTNHTLKQTLSCYSEVWVMPWLKRYEVPVLHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FEK9</accession>
    <name>A0A8B7FEK9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Histone-lysine N-methyltransferase SMYD3</fullName>
            <ecNumber evidence="3">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">SET and MYND domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zinc finger MYND domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SMYD3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with HSPCA. Interacts with HELZ. Interacts with POLR2A; the interaction may be indirect and may be mediated by HELZ. Interacts with HSP90AA1; this interaction enhances SMYD3 histone-lysine N-methyltransferase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03021210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606634.1">
        <property type="nucleotide sequence ID" value="XM_012751180.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FEK9"/>
    <dbReference type="Ensembl" id="ENSMICT00000005663.3">
        <property type="protein sequence ID" value="ENSMICP00000005165.2"/>
        <property type="gene ID" value="ENSMICG00000005665.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863746"/>
    <dbReference type="KEGG" id="mmur:105863746"/>
    <dbReference type="CTD" id="64754"/>
    <dbReference type="GeneTree" id="ENSGT00940000156766"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140939">
        <property type="term" value="F:histone H4 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001162">
        <property type="term" value="F:RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071549">
        <property type="term" value="P:cellular response to dexamethasone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014904">
        <property type="term" value="P:myotube cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19203">
        <property type="entry name" value="SET_SMYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000013">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.160:FF:000003">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000262">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.970:FF:000003">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000017">
        <property type="entry name" value="Histone-lysine N-methyltransferase SMYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025805">
        <property type="entry name" value="Hist-Lys_N-MeTrfase_SMYD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044420">
        <property type="entry name" value="SMYD3_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF288">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51574">
        <property type="entry name" value="SAM_MT43_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="21">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="22">
        <location>
            <begin position="49"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005165.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="428" mass="49092" checksum="6819183C60BB41E8" modified="2022-01-19" version="1">MEPLKVEKFATADRGNGLRAVAALRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWQHHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMEQTPSESEKLYSFYDLESNINKLTEDKKEGLRQLAMTFQHFLREEIQDASQLPPSFDIFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRAQYCFECDCVRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQTIISGNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FF15</accession>
    <name>A0A8B7FF15_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta/gamma crystallin 'Greek key' domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC105863902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606894.1">
        <property type="nucleotide sequence ID" value="XM_012751440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FF15"/>
    <dbReference type="Ensembl" id="ENSMICT00000063140.1">
        <property type="protein sequence ID" value="ENSMICP00000046859.1"/>
        <property type="gene ID" value="ENSMICG00000045866.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105863902"/>
    <dbReference type="KEGG" id="mmur:105863902"/>
    <dbReference type="GeneTree" id="ENSGT00940000158720"/>
    <dbReference type="OrthoDB" id="8407241at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000001">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000003">
        <property type="entry name" value="Crystallin gamma S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF119">
        <property type="entry name" value="GAMMA-CRYSTALLIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="5">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="174" mass="20849" checksum="6BDB3ACD38CF181E" modified="2022-01-19" version="1">MGKITFYEDRGFQGRHYECSSDHPNLQPYLSRCNSVRVDSGCWMLYEQPNYAGSQYFLRRGDYPDYQQWMGLSDSVRSCRLIPHASSHRIRIYEREDHRGQMVETTEDCSSLHDRFRFSEIHSFNVLEGSWILYEHSNYRGRQYLLRPGDYRRHHDWGAMDARVGSLRRAVDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FFR3</accession>
    <name>A0A8B7FFR3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 38 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC38A4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009663">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607131.1">
        <property type="nucleotide sequence ID" value="XM_012751677.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607195.1">
        <property type="nucleotide sequence ID" value="XM_012751741.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607268.1">
        <property type="nucleotide sequence ID" value="XM_012751814.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FFR3"/>
    <dbReference type="Ensembl" id="ENSMICT00000030352.2">
        <property type="protein sequence ID" value="ENSMICP00000037764.1"/>
        <property type="gene ID" value="ENSMICG00000037271.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070319.1">
        <property type="protein sequence ID" value="ENSMICP00000048335.1"/>
        <property type="gene ID" value="ENSMICG00000037271.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105864021"/>
    <dbReference type="KEGG" id="mmur:105864021"/>
    <dbReference type="CTD" id="55089"/>
    <dbReference type="GeneTree" id="ENSGT00940000158917"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015655">
        <property type="term" value="F:alanine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005295">
        <property type="term" value="F:neutral L-amino acid:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904273">
        <property type="term" value="P:L-alanine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF222">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="74"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="325"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="547" mass="60638" checksum="E787D97E59AC4691" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FIF5</accession>
    <name>A0A8B7FIF5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">(Lyso)-N-acylphosphatidylethanolamine lipase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Alpha/beta hydrolase domain-containing protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Alpha/beta-hydrolase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ABHD4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1-O-(1Z-octadecenoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + H2O = 1-O-(1Z-octadecenyl)-sn-glycero-3-phospho-N-hexadecanoyl-ethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55240"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:137009"/>
            <dbReference type="ChEBI" id="CHEBI:138663"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:55241"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + H2O = 1-octadecanoyl-2-hydroxy-sn-glycero-3-phospho-(N-hexadecanoyl)-serine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55236"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:138661"/>
            <dbReference type="ChEBI" id="CHEBI:138662"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:55237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N,1-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:85222"/>
            <dbReference type="ChEBI" id="CHEBI:85229"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:45397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N,1-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:85216"/>
            <dbReference type="ChEBI" id="CHEBI:85225"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:45421"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45400"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:85223"/>
            <dbReference type="ChEBI" id="CHEBI:85230"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:45401"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-eicosanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-eicosanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:85221"/>
            <dbReference type="ChEBI" id="CHEBI:85228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:45393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45424"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:78097"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:45425"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-hexadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:85217"/>
            <dbReference type="ChEBI" id="CHEBI:85226"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:45385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-octadecanoyl-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = N-octadecanoyl-sn-glycero-3-phospho-ethanolamine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45388"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:85219"/>
            <dbReference type="ChEBI" id="CHEBI:85227"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:45389"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = N,1-diacyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:62537"/>
            <dbReference type="ChEBI" id="CHEBI:85216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:45461"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004393">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608238.1">
        <property type="nucleotide sequence ID" value="XM_012752784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FIF5"/>
    <dbReference type="Ensembl" id="ENSMICT00000049417.2">
        <property type="protein sequence ID" value="ENSMICP00000035192.1"/>
        <property type="gene ID" value="ENSMICG00000012697.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864736"/>
    <dbReference type="KEGG" id="mmur:105864736"/>
    <dbReference type="CTD" id="63874"/>
    <dbReference type="GeneTree" id="ENSGT00390000016277"/>
    <dbReference type="OrthoDB" id="7457040at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042171">
        <property type="term" value="F:lysophosphatidic acid acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000044">
        <property type="entry name" value="Abhydrolase domain containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF21">
        <property type="entry name" value="(LYSO)-N-ACYLPHOSPHATIDYLETHANOLAMINE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="19">
        <location>
            <begin position="83"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="355" mass="40362" checksum="1AA2F32267FB4F02" modified="2022-01-19" version="1">MGWLCLTRQGLFTMADDLEQQPQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYISLPNQNKIWTVTVSPEQKDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPTFPRDPEGAEDEFVTSIETWRETMGIPNMILLGHSLGGFLATSYSIKYPERVKHLILVDPWGFPLRPTDPSEIRAPPTWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGANTWIDTSTGKKVKLQRPDSYVRDLEIEGASHHVYADQPHIFNAVVEEICSSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FKF6</accession>
    <name>A0A8B7FKF6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CAP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609062.1">
        <property type="nucleotide sequence ID" value="XM_012753608.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609063.1">
        <property type="nucleotide sequence ID" value="XM_012753609.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FKF6"/>
    <dbReference type="Ensembl" id="ENSMICT00000044922.2">
        <property type="protein sequence ID" value="ENSMICP00000031423.2"/>
        <property type="gene ID" value="ENSMICG00000014446.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865193"/>
    <dbReference type="KEGG" id="mmur:105865193"/>
    <dbReference type="CTD" id="10486"/>
    <dbReference type="GeneTree" id="ENSGT00390000017955"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028417">
        <property type="entry name" value="CAP_CS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF2">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01089">
        <property type="entry name" value="CAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="7">
        <location>
            <begin position="317"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031423.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="477" mass="52948" checksum="FF9935AAA62B2F8F" modified="2022-01-19" version="1">MADMEELVQRLERAVSRLEVLSAESHRRPGDCGEVNGVIGGVAPSVEAFDKLMNGMVAEFLKNSRILAGDVETHAEMVHSAFQAQRAFLLMASQYQQPQENEVATLLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIPALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLSIWSELQAYIKEHHTTGLTWSKTGPVASAVSAFSVLSSGPGFPPPPPPPPPPGPPPLFENEGRKEESSPSRSALFAQLNQGEAITKGLRHVTDDQKTYKNPGLRAQGGQARSPTKSHTPSPTSPKSHPSQKHDPVFELEGKKWRVEYQEDRNDLVISETELKQVAYIFKCDKSTLQIKGKVNSITIDNCKKFALVFDNVVGIVEVINSKDIQIQVMGRVPTISINKTEGCHIYLSEDALDCEIVSAKSSEMNILIPQDGDYREFPVPEQFKTAWDGSKLVTEPAEIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FQ24</accession>
    <name>A0A8B7FQ24_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fatty acid hydroxylase domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FAXDC2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027482">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610934.1">
        <property type="nucleotide sequence ID" value="XM_012755480.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FQ24"/>
    <dbReference type="Ensembl" id="ENSMICT00000051911.2">
        <property type="protein sequence ID" value="ENSMICP00000025003.1"/>
        <property type="gene ID" value="ENSMICG00000000842.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866253"/>
    <dbReference type="KEGG" id="mmur:105866253"/>
    <dbReference type="CTD" id="10826"/>
    <dbReference type="GeneTree" id="ENSGT00940000157328"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045654">
        <property type="term" value="P:positive regulation of megakaryocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="176"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="38854" checksum="1D1EDAE50F6BF666" modified="2022-01-19" version="1">MKGEARSMGQHDKSKQEGHIWGSMRRTAFILGSGLLLFVAFWNSVTWHLQRFWGASGYFWQAQWERLLSTYEGKEWILYIIGATHVPSLCFWTFNGLLLVVDTTGKPNFISRYRIQVGKNEPVDPVKLRQSIRTVLFNQFFISLPMLVFLYPFLKWWGDPCRRELPTFHWFLLELAIFTLIEEVLFYYSHRLLHHPIFYKKIHKKHHEWTAPIGVISLYAHPIEHVASNMLPAMAGPIIMGSHLSSITMWFSLALIITTISHCGYHLPFLPSPEFHDYHHLKFTQCYGVLGVLDHLHGTDTQFKQTKAYERHILLLGFTPLSESIPDSPKKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FQN4</accession>
    <name>A0A8B7FQN4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING finger protein 141</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RNF141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in spermatogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611288.1">
        <property type="nucleotide sequence ID" value="XM_012755834.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FQN4"/>
    <dbReference type="Ensembl" id="ENSMICT00000065087.1">
        <property type="protein sequence ID" value="ENSMICP00000043636.1"/>
        <property type="gene ID" value="ENSMICG00000044602.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866493"/>
    <dbReference type="KEGG" id="mmur:105866493"/>
    <dbReference type="CTD" id="50862"/>
    <dbReference type="GeneTree" id="ENSGT00390000003145"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16545">
        <property type="entry name" value="RING-HC_RNF141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000160">
        <property type="entry name" value="Ring finger protein 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043400">
        <property type="entry name" value="RING-HC_RNF141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047126">
        <property type="entry name" value="RNF141-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109:SF3">
        <property type="entry name" value="RING FINGER PROTEIN 141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12109">
        <property type="entry name" value="RING FINGER PROTEIN 141-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="230" mass="25536" checksum="ED77788ED3FFF35A" modified="2022-01-19" version="1">MGQQISDQTQLVISKLPEKVAKHITLVRESGSLTYEEFLGRVAELNDVTAKVASGQEKHLLFEVQPGSDSSAFWKVVVRVVCTKINKSSGIVEASRIMNLYQFIQLYKDITTQAAGVLAQSSTSEEPDENSSSVTSCQASLWMGRVKQLTDEEECCICMDGRADLILPCAHSFCQKCIDKWSDRHRNCPICRLQMTGANESWVVSDAPTEDDMANYILNMADEAGQPHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FT45</accession>
    <name>A0A8B7FT45_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase receptor</fullName>
            <ecNumber evidence="18">2.7.11.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ACVR2B</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[receptor-protein] + ATP = O-phospho-L-seryl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18673"/>
            <dbReference type="Rhea" id="RHEA-COMP:11022"/>
            <dbReference type="Rhea" id="RHEA-COMP:11023"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[receptor-protein] + ATP = O-phospho-L-threonyl-[receptor-protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44880"/>
            <dbReference type="Rhea" id="RHEA-COMP:11024"/>
            <dbReference type="Rhea" id="RHEA-COMP:11025"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="18">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.30" evidence="18"/>
    <dbReference type="EMBL" id="ABDC03000473">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611859.1">
        <property type="nucleotide sequence ID" value="XM_012756405.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FT45"/>
    <dbReference type="Ensembl" id="ENSMICT00000072679.1">
        <property type="protein sequence ID" value="ENSMICP00000051007.1"/>
        <property type="gene ID" value="ENSMICG00000049276.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866814"/>
    <dbReference type="CTD" id="93"/>
    <dbReference type="GeneTree" id="ENSGT00940000156210"/>
    <dbReference type="OrthoDB" id="547665at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048179">
        <property type="term" value="C:activin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048185">
        <property type="term" value="F:activin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016362">
        <property type="term" value="F:activin receptor activity, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071363">
        <property type="term" value="P:cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032927">
        <property type="term" value="P:positive regulation of activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051239">
        <property type="term" value="P:regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14140">
        <property type="entry name" value="STKc_ACVR2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23632">
        <property type="entry name" value="TFP_LU_ECD_ACVR2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000099">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000094">
        <property type="entry name" value="Serine/threonine-protein kinase receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000472">
        <property type="entry name" value="Activin_recp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000333">
        <property type="entry name" value="TGFB_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255:SF70">
        <property type="entry name" value="ACTIVIN RECEPTOR TYPE-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23255">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR TYPE I AND II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01064">
        <property type="entry name" value="Activin_recp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00653">
        <property type="entry name" value="ACTIVIN2R"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 18" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 18" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133675" description="Serine/threonine-protein kinase receptor" evidence="19">
        <location>
            <begin position="23"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="190"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="512" mass="57726" checksum="A129A6EB1CACD2A0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G186</accession>
    <name>A0A8B7G186_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Transcriptional repressor scratch 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Scratch homolog 1 zinc finger protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SCRT1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts (via SNAG domain) with LIMD1 (via LIM domains), WTIP (via LIM domains) and AJUBA (via LIM domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the snail C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013935">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615724.1">
        <property type="nucleotide sequence ID" value="XM_012760270.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G186"/>
    <dbReference type="Ensembl" id="ENSMICT00000063874.1">
        <property type="protein sequence ID" value="ENSMICP00000045126.1"/>
        <property type="gene ID" value="ENSMICG00000047717.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105868899"/>
    <dbReference type="KEGG" id="mmur:105868899"/>
    <dbReference type="CTD" id="83482"/>
    <dbReference type="GeneTree" id="ENSGT00940000154491"/>
    <dbReference type="OrthoDB" id="5428132at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001222">
        <property type="term" value="P:regulation of neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000560">
        <property type="entry name" value="Scratch family transcriptional repressor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000043">
        <property type="entry name" value="Scratch family zinc finger 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000169">
        <property type="entry name" value="transcriptional repressor scratch 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000207">
        <property type="entry name" value="zinc finger protein SNAI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF60">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR SCRATCH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="129"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="349" mass="35859" checksum="3C4411A72A5252E3" modified="2022-01-19" version="1">MPRSFLVKKVKLDTFSSADLESSYGRARGDLGVRLHDKGYLSDYVGPSVYDGDAEAALLKGPSPEPMYAAAVRGELGPAAAGSAPPPTPRPELATAAGGYINGDAAVSEGYAADAFFITDGRSRRKATNANAAAAPSTASGAAPDGDAGVGGGAGARSSGSGPGGRGGTRAGAGTEARAGPGVAGTGGRHACGECGKTYATSSNLSRHKQTHRSLDSQLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCGKAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYLNKHYESACFKGGAGSGGPAAPAPPQLSPVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G6Q3</accession>
    <name>A0A8B7G6Q3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Activating transcription factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATF1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009622">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617667.1">
        <property type="nucleotide sequence ID" value="XM_012762213.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G6Q3"/>
    <dbReference type="Ensembl" id="ENSMICT00000003296.3">
        <property type="protein sequence ID" value="ENSMICP00000002993.2"/>
        <property type="gene ID" value="ENSMICG00000003301.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869965"/>
    <dbReference type="CTD" id="466"/>
    <dbReference type="GeneTree" id="ENSGT00940000158200"/>
    <dbReference type="OrthoDB" id="5970722at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990590">
        <property type="term" value="C:ATF1-ATF4 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990589">
        <property type="term" value="C:ATF4-CREB1 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141156">
        <property type="term" value="P:cAMP/PKA signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014074">
        <property type="term" value="P:response to purine-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF2">
        <property type="entry name" value="CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50953">
        <property type="entry name" value="KID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="KID" evidence="9">
        <location>
            <begin position="31"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="230"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002993.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="270" mass="29296" checksum="427F3D01934C6815" modified="2022-01-19" version="1">MEDSHKNNTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKIFKDLSSEDTRGRKGDGENPGVSAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGNTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSHKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GDY9</accession>
    <name>A0A8B7GDY9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Dimethylaniline monooxygenase [N-oxide-forming]</fullName>
            <ecNumber evidence="20">1.14.13.148</ecNumber>
            <ecNumber evidence="20">1.14.13.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FMO1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15 20">Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>N,N-dimethylaniline + NADPH + O2 + H(+) = N,N-dimethylaniline N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:24468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16269"/>
            <dbReference type="ChEBI" id="CHEBI:17735"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:24469"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hypotaurine + NADH + O2 + H(+) = taurine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:74111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:74112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypotaurine + NADPH + O2 + H(+) = taurine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:69819"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57853"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
            <dbReference type="EC" id="1.14.13.8"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:69820"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:31979"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15724"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58389"/>
            <dbReference type="EC" id="1.14.13.148"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:31980"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20 21">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20 21">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.148" evidence="20"/>
    <dbReference type="EC" id="1.14.13.8" evidence="20"/>
    <dbReference type="EMBL" id="ABDC03003355">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620610.1">
        <property type="nucleotide sequence ID" value="XM_012765156.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620611.1">
        <property type="nucleotide sequence ID" value="XM_012765157.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GDY9"/>
    <dbReference type="Ensembl" id="ENSMICT00000043128.2">
        <property type="protein sequence ID" value="ENSMICP00000022075.1"/>
        <property type="gene ID" value="ENSMICG00000017112.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871687"/>
    <dbReference type="CTD" id="2326"/>
    <dbReference type="GeneTree" id="ENSGT00940000160945"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034899">
        <property type="term" value="F:trimethylamine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000042">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000073">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000144">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000777">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002253">
        <property type="entry name" value="Flavin_mOase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01121">
        <property type="entry name" value="FMOXYGENASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20 21" id="KW-0274">FAD</keyword>
    <keyword evidence="5 20 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="13 20 21" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 20" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRNR" id="PIRNR000332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="532" mass="60004" checksum="66520494FF18AAAB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GE30</accession>
    <name>A0A8B7GE30_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="33">Dynamin-2</fullName>
            <ecNumber evidence="8">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="39" type="primary">DNM3</name>
    </gene>
    <organism evidence="39 40">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="39" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="39" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="39" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Phagocytic cup</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="32">Cell projection</location>
            <location evidence="32">Uropodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Cytoplasmic vesicle</location>
            <location evidence="30">Phagosome membrane</location>
            <topology evidence="30">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <location evidence="7">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Postsynaptic density</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Recycling endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Synapse</location>
            <location evidence="28">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="34">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03003362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620582.1">
        <property type="nucleotide sequence ID" value="XM_012765128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GE30"/>
    <dbReference type="Ensembl" id="ENSMICT00000005116.3">
        <property type="protein sequence ID" value="ENSMICP00000004666.3"/>
        <property type="gene ID" value="ENSMICG00000005116.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871673"/>
    <dbReference type="CTD" id="26052"/>
    <dbReference type="GeneTree" id="ENSGT00940000158056"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
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        <property type="project" value="GOC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Dynamin_GTPase_CS"/>
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        <property type="entry name" value="Dynamin_stalk"/>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
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        <property type="entry name" value="GED"/>
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        <property type="entry name" value="GED_dom"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="DYNAMIN-3"/>
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        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
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            <begin position="515"/>
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        </location>
    </feature>
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            <begin position="649"/>
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        </location>
    </feature>
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            <begin position="623"/>
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        </location>
    </feature>
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            <begin position="738"/>
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        </location>
    </feature>
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        <location>
            <begin position="765"/>
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        </location>
    </feature>
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        <location>
            <begin position="787"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="35">
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            <begin position="822"/>
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        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
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            <dbReference type="ARBA" id="ARBA00004231"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
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            <dbReference type="ARBA" id="ARBA00023212"/>
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            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
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            <dbReference type="ARBA" id="ARBA00034105"/>
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            <dbReference type="ARBA" id="ARBA00046301"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00050873"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060447"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="36">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
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    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004666.3"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="859" mass="96742" checksum="D0D389BE347177E3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GEH3</accession>
    <name>A0A8B7GEH3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">E3 ubiquitin-protein ligase TRIM62</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Tripartite motif-containing protein 62</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TRIM62</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with the ubiquitin-conjugating enzyme, UBE2D2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03001626">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620808.1">
        <property type="nucleotide sequence ID" value="XM_012765354.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620809.1">
        <property type="nucleotide sequence ID" value="XM_012765355.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GEH3"/>
    <dbReference type="Ensembl" id="ENSMICT00000035802.2">
        <property type="protein sequence ID" value="ENSMICP00000020628.1"/>
        <property type="gene ID" value="ENSMICG00000028440.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061748.1">
        <property type="protein sequence ID" value="ENSMICP00000047878.1"/>
        <property type="gene ID" value="ENSMICG00000028440.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871788"/>
    <dbReference type="KEGG" id="mmur:105871788"/>
    <dbReference type="CTD" id="55223"/>
    <dbReference type="GeneTree" id="ENSGT00940000158433"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010719">
        <property type="term" value="P:negative regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032897">
        <property type="term" value="P:negative regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905036">
        <property type="term" value="P:positive regulation of antifungal innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044314">
        <property type="term" value="P:protein K27-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046596">
        <property type="term" value="P:regulation of viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19792">
        <property type="entry name" value="Bbox2_TRIM62_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16608">
        <property type="entry name" value="RING-HC_TRIM62_C-IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13744">
        <property type="entry name" value="SPRY_PRY_TRIM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000041">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001508">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000389">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035830">
        <property type="entry name" value="PRY/SPRY_TRIM62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="23">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="24">
        <location>
            <begin position="277"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="129"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00059305"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
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            <dbReference type="ARBA" id="ARBA00065049"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
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            <dbReference type="ARBA" id="ARBA00073095"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
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            <dbReference type="ARBA" id="ARBA00076781"/>
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    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="475" mass="54253" checksum="F4A2BDFA488F6A20" modified="2022-01-19" version="1">MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLANIVERYSAFPLDAILSARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFEELQRELKEQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGVHYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFLDYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GEN2</accession>
    <name>A0A8B7GEN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Phytanoyl-CoA dioxygenase, peroxisomal</fullName>
            <ecNumber evidence="10">1.14.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phytanic acid oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Phytanoyl-CoA alpha-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">PHYH</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-methylbutanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxy-3-methylbutanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54612"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57345"/>
            <dbReference type="ChEBI" id="CHEBI:138296"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:54613"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>3-methyldodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxy-3-methyldodecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:55192"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138636"/>
            <dbReference type="ChEBI" id="CHEBI:138637"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:55193"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>3-methylhexadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxy-3-methylhexadecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:44000"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58784"/>
            <dbReference type="ChEBI" id="CHEBI:83969"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:44001"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>3-methylnonanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxy-3-methylnonanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:55180"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:138633"/>
            <dbReference type="ChEBI" id="CHEBI:138634"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:55181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>3-methylundecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxy-3-methylundecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:55184"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:84183"/>
            <dbReference type="ChEBI" id="CHEBI:138632"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:55185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>butanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxybutanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:55176"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:138628"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:55177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>decanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54604"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
            <dbReference type="ChEBI" id="CHEBI:138292"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dodecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxydodecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54628"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:138299"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:54629"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>eicosanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyeicosanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54620"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
            <dbReference type="ChEBI" id="CHEBI:138298"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:54621"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>heptadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyheptadecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54616"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74307"/>
            <dbReference type="ChEBI" id="CHEBI:138297"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:54617"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyhexadecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54596"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>hexanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyhexanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:55172"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
            <dbReference type="ChEBI" id="CHEBI:138630"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:55173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54624"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:54625"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>octanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54600"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:138290"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:54601"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>phytanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyphytanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:16065"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57334"/>
            <dbReference type="ChEBI" id="CHEBI:57391"/>
            <dbReference type="EC" id="1.14.11.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16066"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tetradecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxytetradecanoyl-CoA + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54632"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:138300"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:54633"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="29">
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.18" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03028384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621160.1">
        <property type="nucleotide sequence ID" value="XM_012765706.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GEN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000050233.2">
        <property type="protein sequence ID" value="ENSMICP00000022494.1"/>
        <property type="gene ID" value="ENSMICG00000035907.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871998"/>
    <dbReference type="KEGG" id="mmur:105871998"/>
    <dbReference type="CTD" id="5264"/>
    <dbReference type="GeneTree" id="ENSGT00390000001775"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097731">
        <property type="term" value="C:9+0 non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097089">
        <property type="term" value="P:methyl-branched fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000012">
        <property type="entry name" value="Phytanoyl-CoA dioxygenase, peroxisomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF1">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0847">Vitamin C</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00051281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00051796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00051952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00052152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00052528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00052623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00053028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00071213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="338" mass="39108" checksum="2BEAC745525DB42A" modified="2022-01-19" version="1">MNQSRAATRLRTLLGHLGGPPAEAAVAHPTLGSSSFANFHPQQFQYTLDNNVLSLEQRKFYEENGFLLIKNLVSDEDIQRFQNEFEKICRQEVKPLGLHIMRDVTISKSEYDPKNEQMVCKIQDFQEDEELFRYCTLPEILKYVECFTGPNIMAMHTMMINKPPDSGKKTSRHPLHQDLHYFPFRPTDRIVCAWTAMEHIDRNNGCLCVIPGSHKGHLQPHDYPQWEGGVNIMFHGIQNFKDYDARVHIQMEKGDTLFFHPLLIHGSGRNTTQRFRKAISCHFSTADGYYIDVKGTTQENIEKEVQGIASRLYGVDNTNLKDFWMFRARLVKGERTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GES2</accession>
    <name>A0A8B7GES2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Testis-specific serine/threonine-protein kinase 3</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Serine/threonine-protein kinase 22C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">TSSK3</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Serine/threonine protein kinase required for spermatid development and male fertility.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03001599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620857.1">
        <property type="nucleotide sequence ID" value="XM_012765403.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GES2"/>
    <dbReference type="Ensembl" id="ENSMICT00000014376.3">
        <property type="protein sequence ID" value="ENSMICP00000013105.3"/>
        <property type="gene ID" value="ENSMICG00000014383.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871807"/>
    <dbReference type="KEGG" id="mmur:105871807"/>
    <dbReference type="CTD" id="81629"/>
    <dbReference type="GeneTree" id="ENSGT00940000161490"/>
    <dbReference type="OMA" id="HVMLCAS"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14163">
        <property type="entry name" value="STKc_TSSK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000485">
        <property type="entry name" value="testis-specific serine/threonine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042709">
        <property type="entry name" value="TSSK3_STKc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="18" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="10"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00057250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00071770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00080152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013105.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="268" mass="30233" checksum="3A00795C645D9EBB" modified="2022-01-19" version="1">MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIRVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKLRRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISAECQDLLKRLLEPDMILRPSIEEVSWHPWLAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GGQ9</accession>
    <name>A0A8B7GGQ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Solute carrier family 35 member G1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC35G1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with STIM1; stimulated by depletion of intracellular calcium. Interacts with ORAI1. Interacts with the plasma membrane calcium-transporting ATPases ATP2B1 and ATP2B4. Interacts with ATP1A1, ATP2A2, KPNB1 and XPO1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TMEM20 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019320">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621670.1">
        <property type="nucleotide sequence ID" value="XM_012766216.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GGQ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000061083.1">
        <property type="protein sequence ID" value="ENSMICP00000045804.1"/>
        <property type="gene ID" value="ENSMICG00000045783.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872317"/>
    <dbReference type="KEGG" id="mmur:105872317"/>
    <dbReference type="CTD" id="159371"/>
    <dbReference type="GeneTree" id="ENSGT00940000153249"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990034">
        <property type="term" value="P:calcium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000026">
        <property type="entry name" value="Solute carrier family 35, member G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="16">
        <location>
            <begin position="70"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="16">
        <location>
            <begin position="224"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00082789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="365" mass="39680" checksum="2860BB6B39C56367" modified="2022-01-19" version="1">MRPEDGAGAAEPGEPVLLLTDDAPPGASEEPAAAGTEGAPGRGRCWLCPASPCGSRAEPEAKKKAPCPGLGLLYTLLSAFLFSLTSLFVKKVQDVHAVEISAFRCVFQMLIVIPCLIYRKTGFIGPKGQRIFLVLRGVLGSTSMILIYYAFQTMPLADATVITFSTPVFTSIFAWIFLKEKYSPWDALFTMFSITGVILIVRPPFLFGSSSSGTEESYSVHLQGTLAAIGHAVFSGMTLVILRKMGKSVDYFLSIWYYVITGLLESTIVLFILGEWSLPYCGFDRLYLVLIGTVGLGAQVFLTKGLQIEKAGPVAVMRAMDVVFAFIFQIIFFNQVPSWWTVGGAICLVASSIGAAIHRWYQSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GL31</accession>
    <name>A0A8B7GL31_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HIPK2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03015165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623448.1">
        <property type="nucleotide sequence ID" value="XM_012767994.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GL31"/>
    <dbReference type="Ensembl" id="ENSMICT00000026962.2">
        <property type="protein sequence ID" value="ENSMICP00000019707.1"/>
        <property type="gene ID" value="ENSMICG00000003143.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873226"/>
    <dbReference type="CTD" id="28996"/>
    <dbReference type="GeneTree" id="ENSGT00940000157742"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046790">
        <property type="term" value="F:virion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007628">
        <property type="term" value="P:adult walking behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048596">
        <property type="term" value="P:embryonic camera-type eye morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060059">
        <property type="term" value="P:embryonic retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061072">
        <property type="term" value="P:iris morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060235">
        <property type="term" value="P:lens induction in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060425">
        <property type="term" value="P:lung morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000059">
        <property type="term" value="P:negative regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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</entry>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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    </evidence>
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        <source>
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    <sequence length="364" mass="40074" checksum="F0650370F9B242B2" modified="2022-01-19" version="1">MERRRLLGGMALLLLQALPSPLPARAEPPQDKEACVGTNNQSYICDTGHCCGQSQCCNYYYELWWFWLVWTIIIILSCCCVCHHRRAKHRLQAQQRQHEINLIAYREAHNYSALPFYFRFLPNYLLPPYEEVVNRPPTPPPPYSAFQLQQQQLPPQCGPAGGSPPGADPTRGSPGAQSSPLSGPSRSSTRPPSIADPEPSDLPADQAATKAPGMEPSGSVAGLGELDPGPFLDKDSECREELLKDYSPEHGSVLPDSKDKTPGRHRRFTGDSGIEVCVCNRGHHDDDLKEFNTLIDDALDGPLDFCDSCHVRPPGDEEEGLCQPSEEQAREPGHPHLPRPPACLLLNTINEQDSPNSQSSSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GYN3</accession>
    <name>A0A8B7GYN3_MICMU</name>
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        <recommendedName>
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        <name evidence="19" type="synonym">LOC105876468</name>
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        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 17">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="17">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628786.1">
        <property type="nucleotide sequence ID" value="XM_012773332.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629604.1">
        <property type="nucleotide sequence ID" value="XM_012774150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GYN3"/>
    <dbReference type="SMR" id="A0A8B7GYN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000067406.1">
        <property type="protein sequence ID" value="ENSMICP00000046063.1"/>
        <property type="gene ID" value="ENSMICG00000045862.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105875906"/>
    <dbReference type="GeneID" id="105876468"/>
    <dbReference type="KEGG" id="mmur:105875906"/>
    <dbReference type="KEGG" id="mmur:105876468"/>
    <dbReference type="CTD" id="54205"/>
    <dbReference type="GeneTree" id="ENSGT00390000009405"/>
    <dbReference type="OMA" id="MPAPYKK"/>
    <dbReference type="OrthoDB" id="9508248at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000008">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_012628786.1"/>
        </source>
    </evidence>
    <sequence length="105" mass="11605" checksum="B5BCA779BCE40492" modified="2022-01-19" version="1">MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H710</accession>
    <name>A0A8B7H710_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Collagen type III alpha 1 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">COL3A1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632307.1">
        <property type="nucleotide sequence ID" value="XM_012776853.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000014209.3">
        <property type="protein sequence ID" value="ENSMICP00000012954.3"/>
        <property type="gene ID" value="ENSMICG00000014169.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877880"/>
    <dbReference type="KEGG" id="mmur:105877880"/>
    <dbReference type="CTD" id="1281"/>
    <dbReference type="GeneTree" id="ENSGT00940000161229"/>
    <dbReference type="OrthoDB" id="8939548at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005586">
        <property type="term" value="C:collagen type III trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048407">
        <property type="term" value="F:platelet-derived growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060414">
        <property type="term" value="P:aorta smooth muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002062">
        <property type="term" value="P:chondrocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048565">
        <property type="term" value="P:digestive tract development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048251">
        <property type="term" value="P:elastic fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="23513" checksum="52D1517EA742A30C" modified="2022-01-19" version="1">MVMAEGTAVLRRNRPGTKAQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HDH5</accession>
    <name>A0A8B7HDH5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine-protein phosphatase non-receptor type</fullName>
            <ecNumber evidence="10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PTPN11</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03024899">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024904">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633812.1">
        <property type="nucleotide sequence ID" value="XM_012778358.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HDH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000029419.2">
        <property type="protein sequence ID" value="ENSMICP00000021030.2"/>
        <property type="gene ID" value="ENSMICG00000011410.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105878675"/>
    <dbReference type="CTD" id="5781"/>
    <dbReference type="GeneTree" id="ENSGT00940000153876"/>
    <dbReference type="OrthoDB" id="8815311at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902564">
        <property type="term" value="P:negative regulation of neutrophil activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060338">
        <property type="term" value="P:regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14605">
        <property type="entry name" value="PTPc-N11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09931">
        <property type="entry name" value="SH2_C-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10340">
        <property type="entry name" value="SH2_N-SH2_SHP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000012">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000018">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012152">
        <property type="entry name" value="Tyr_Pase_non-rcpt_typ-6/11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46559:SF1">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000929">
        <property type="entry name" value="Tyr-Ptase_nr_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 13" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="112"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="16">
        <location>
            <begin position="247"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="17">
        <location>
            <begin position="440"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="554"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="11">
        <location>
            <position position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="597" mass="68449" checksum="443B77A1ABEF9BC2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HEY0</accession>
    <name>A0A8B7HEY0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="4 9">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LCMT1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 9">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="4 9"/>
    <dbReference type="EMBL" id="ABDC03021007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635583.1">
        <property type="nucleotide sequence ID" value="XM_012780129.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HEY0"/>
    <dbReference type="Ensembl" id="ENSMICT00000001574.3">
        <property type="protein sequence ID" value="ENSMICP00000001430.2"/>
        <property type="gene ID" value="ENSMICG00000001568.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879704"/>
    <dbReference type="KEGG" id="mmur:105879704"/>
    <dbReference type="CTD" id="51451"/>
    <dbReference type="GeneTree" id="ENSGT00940000156372"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090266">
        <property type="term" value="P:regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000092">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF33">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001430.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="335" mass="38426" checksum="D25ECA0479FD3E38" modified="2022-01-19" version="1">MAGSLREPPSFTPGSSSSSRDTDDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLTKERKAPEINRGYFARVHGVNQLMKAFLRKTECHCQIFNLGAGMDTTFWNLKDEDLLPTKYFEVDFPMIVSRKLHNIKNKPPLSNPIIELHSEDTLHMDGHILDSKRYAIIGADLRDTHVLEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWATNTFETAMLINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLLSTGWETASVVDMMELYSRLPRAEVTRIESLEFLDEVELLEQLMQHYCLCWATKGGSELGLKDITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HM59</accession>
    <name>A0A8B7HM59_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Non-histone chromosomal protein HMG-17</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">High mobility group nucleosome-binding domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">HMGN2</name>
        <name evidence="10" type="synonym">LOC105881539</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606045.1">
        <property type="nucleotide sequence ID" value="XM_012750591.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638692.1">
        <property type="nucleotide sequence ID" value="XM_012783238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HM59"/>
    <dbReference type="Ensembl" id="ENSMICT00000045817.2">
        <property type="protein sequence ID" value="ENSMICP00000036326.1"/>
        <property type="gene ID" value="ENSMICG00000032007.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000072952.1">
        <property type="protein sequence ID" value="ENSMICP00000051608.1"/>
        <property type="gene ID" value="ENSMICG00000049058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105863488"/>
    <dbReference type="GeneID" id="105881539"/>
    <dbReference type="KEGG" id="mmur:105863488"/>
    <dbReference type="KEGG" id="mmur:105881539"/>
    <dbReference type="GeneTree" id="ENSGT00950000182802"/>
    <dbReference type="OMA" id="SEQQHCR"/>
    <dbReference type="OrthoDB" id="9908225at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000079">
        <property type="entry name" value="HMGN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087:SF13">
        <property type="entry name" value="NON-HISTONE CHROMOSOMAL PROTEIN HMG-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087">
        <property type="entry name" value="NONHISTONE CHROMOSOMAL PROTEIN HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01101">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00925">
        <property type="entry name" value="NONHISHMG17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00527">
        <property type="entry name" value="HMG17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00355">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="90" mass="9395" checksum="B1D717D926CCECC8" modified="2022-01-19" version="1">MPKRKAEGDAKGDKAKAKDEPQRRSARLSAKPAPPKPEPKPKKAPAKKGEKVPKGKKGKADTGKEGNNPAENGDAKTDQAQKAEGAGDAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HQG3</accession>
    <name>A0A8B7HQG3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EIF1AX</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6 10">Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 43S pre-initiation complex (43S PIC), which is composed of the 40S ribosomal subunit, EIF1, eIF1A (EIF1AX), eIF3 complex, EIF5 and eIF2-GTP-initiator tRNA complex (eIF2 ternary complex). Interacts with EIF5; this interaction contributes to the maintenance of EIF1 within the open 43S PIC. Interacts through its C-terminal domain (CTD) with the CTD of EIF5B; from the location of the start codon by the 43S complex until the formation of the 80S complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eIF-1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035962">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640094.1">
        <property type="nucleotide sequence ID" value="XM_012784640.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HQG3"/>
    <dbReference type="SMR" id="A0A8B7HQG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000064934.1">
        <property type="protein sequence ID" value="ENSMICP00000044826.1"/>
        <property type="gene ID" value="ENSMICG00000004110.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882368"/>
    <dbReference type="KEGG" id="mmur:105882368"/>
    <dbReference type="CTD" id="1964"/>
    <dbReference type="GeneTree" id="ENSGT00390000008256"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000071">
        <property type="entry name" value="Eukaryotic translation initiation factor 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="12">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="144" mass="16460" checksum="1C4209855B21BFD4" modified="2022-01-19" version="1">MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I387</accession>
    <name>A0A8B7I387_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Polycomb group RING finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nervous system Polycomb-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PCGF1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Interacts with BCORL1, forming heterodimers. The PCGF1-BCORL1 heterodimeric complex interacts with the KDM2B-SKP1 heterodimeric complex to form a homotetrameric polycomb repression complex 1 (PRC1.1). Component of the repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, RING1 and RNF2/RING2. Specifically interacts with BCOR, RING1 and RNF2/RING2. Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. Interacts with DPPA4, NANOG, POU5F1 and RYBP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644055.1">
        <property type="nucleotide sequence ID" value="XM_012788601.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I387"/>
    <dbReference type="Ensembl" id="ENSMICT00000052908.2">
        <property type="protein sequence ID" value="ENSMICP00000030857.1"/>
        <property type="gene ID" value="ENSMICG00000006222.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884577"/>
    <dbReference type="KEGG" id="mmur:105884577"/>
    <dbReference type="CTD" id="84759"/>
    <dbReference type="GeneTree" id="ENSGT00940000159651"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17081">
        <property type="entry name" value="RAWUL_PCGF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16733">
        <property type="entry name" value="RING-HC_PCGF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000099">
        <property type="entry name" value="Polycomb group RING finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000122">
        <property type="entry name" value="polycomb group RING finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032443">
        <property type="entry name" value="RAWUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825:SF29">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10825">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING, POLYCOMB GROUP COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16207">
        <property type="entry name" value="RAWUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="259" mass="30319" checksum="4673E630A4F71A7B" modified="2022-01-19" version="1">MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPSGEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEILPDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XD67</accession>
    <name>A0A8B7XD67_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Multiple C2 and transmembrane domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MCTP1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016879">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016882">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145766.1">
        <property type="nucleotide sequence ID" value="XM_020290177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XD67"/>
    <dbReference type="Ensembl" id="ENSMICT00000066092.1">
        <property type="protein sequence ID" value="ENSMICP00000048655.1"/>
        <property type="gene ID" value="ENSMICG00000006657.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105864136"/>
    <dbReference type="CTD" id="79772"/>
    <dbReference type="GeneTree" id="ENSGT00940000156031"/>
    <dbReference type="OrthoDB" id="5973539at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046928">
        <property type="term" value="P:regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04042">
        <property type="entry name" value="C2A_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08376">
        <property type="entry name" value="C2B_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08377">
        <property type="entry name" value="C2C_MCTP_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000050">
        <property type="entry name" value="Multiple C2 and transmembrane domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000068">
        <property type="entry name" value="multiple C2 and transmembrane domain-containing protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000019">
        <property type="entry name" value="Multiple C2 and transmembrane domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45911:SF3">
        <property type="entry name" value="DYSFERLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
        <property type="entry name" value="C2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="806"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="913"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="240"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="450"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="18">
        <location>
            <begin position="601"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="93"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="997" mass="111696" checksum="8DECE70426876348" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XD75</accession>
    <name>A0A8B7XD75_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ADAMTS like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ADAMTSL2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015001">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145140.1">
        <property type="nucleotide sequence ID" value="XM_020289551.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145141.1">
        <property type="nucleotide sequence ID" value="XM_020289552.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145142.1">
        <property type="nucleotide sequence ID" value="XM_020289553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XD75"/>
    <dbReference type="Ensembl" id="ENSMICT00000045130.2">
        <property type="protein sequence ID" value="ENSMICP00000028452.1"/>
        <property type="gene ID" value="ENSMICG00000031225.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880756"/>
    <dbReference type="CTD" id="9719"/>
    <dbReference type="GeneTree" id="ENSGT00940000159447"/>
    <dbReference type="OrthoDB" id="5781878at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.830:FF:000001">
        <property type="entry name" value="A disintegrin and metalloproteinase with thrombospondin motifs 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.830">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013273">
        <property type="entry name" value="ADAMTS/ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045371">
        <property type="entry name" value="ADAMTS_CR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010294">
        <property type="entry name" value="ADAMTS_spacer1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010909">
        <property type="entry name" value="PLAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF147">
        <property type="entry name" value="ADAMTS-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19236">
        <property type="entry name" value="ADAMTS_CR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05986">
        <property type="entry name" value="ADAMTS_spacer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08686">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01857">
        <property type="entry name" value="ADAMTSFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50900">
        <property type="entry name" value="PLAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135575" evidence="8">
        <location>
            <begin position="30"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="domain" description="PLAC" evidence="9">
        <location>
            <begin position="916"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="524"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613273-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="955" mass="104683" checksum="0C78FA7D20314FA8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UKY5</accession>
    <name>A0A8C5UKY5_MICMU</name>
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        <submittedName>
            <fullName evidence="7">PDZ binding kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PBK</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03023684">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630834.1">
        <property type="nucleotide sequence ID" value="XM_012775380.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UKY5"/>
    <dbReference type="Ensembl" id="ENSMICT00000001282.3">
        <property type="protein sequence ID" value="ENSMICP00000001170.2"/>
        <property type="gene ID" value="ENSMICG00000001285.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877135"/>
    <dbReference type="KEGG" id="mmur:105877135"/>
    <dbReference type="CTD" id="55872"/>
    <dbReference type="GeneTree" id="ENSGT00720000108839"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032873">
        <property type="term" value="P:negative regulation of stress-activated MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14001">
        <property type="entry name" value="PKc_TOPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000556">
        <property type="entry name" value="Lymphokine-activated killer T-cell-originated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041989">
        <property type="entry name" value="PKc_TOPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF14">
        <property type="entry name" value="LYMPHOKINE-ACTIVATED KILLER T-CELL-ORIGINATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="32"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001170.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="323" mass="36272" checksum="D24FFADEE94147D0" modified="2022-01-19" version="1">MEGISNFKTPSKLSEKSKSASCSTPCINIPASPFMQKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNEHYRSVYQKRLTDEAKILKSLHHPNIVGYRAFTEASDGSLCLAMEYGGEKSLNDLIEERRKDSRDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLTLDENMTVTDPEACYIGTEPWKPKEALEENGIITDKADIFAFGLTLWEMMTLSIPHMNLSDDDDDDKTFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEEPKDRPSAARIVEALEIDVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNQ9</accession>
    <name>A0A8C5UNQ9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycolipid transfer protein domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GLTPD2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNQ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000000159.3">
        <property type="protein sequence ID" value="ENSMICP00000000143.3"/>
        <property type="gene ID" value="ENSMICG00000000159.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162518"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF19">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycolipid transfer protein" evidence="3">
        <location>
            <begin position="98"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000143.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="244" mass="26601" checksum="5DB9D356658DB3F3" modified="2022-01-19" version="1">MGVAGGPLARQHCFRHSVPITIFLLLLLYLSARILGTLSGCGSWAQACIPEGPPPFQVRSGQAQVPQRWKEPSCLEPQGMLGRMMRPFRASLNPAGDVELSQYLAGWRELVKLLTPLGSIFTFATSEASTKVTALEARLRGPDAEHYTSLAAMVAWERRAGLLGARRGRPGDSGPALGSRTLLLAPLRRVPTCLHRWADRGARSPDAGAQCSDAYRTALPRTARPRHRTLEDHNRTPSSPLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQJ4</accession>
    <name>A0A8C5UQJ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Component of gems 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Survival of motor neuron protein-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GEMIN2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Monomer. Part of the core SMN complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8 and STRAP/UNRIP. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG. Interacts with GEMIN5; the interaction is direct. Interacts (via C-terminus) with SMN1; the interaction is direct. Interacts with SNRPD1; the interaction is direct. Interacts with SNRPD2; the interaction is direct. Interacts (via N-terminus) with SNRPF; the interaction is direct. Interacts (via N-terminus) with SNRPE; the interaction is direct. Interacts (via N-terminus) with SNRPG; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Gem</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the gemin-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004182">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQJ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000004815.3">
        <property type="protein sequence ID" value="ENSMICP00000004387.3"/>
        <property type="gene ID" value="ENSMICG00000004811.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013814"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097504">
        <property type="term" value="C:Gemini of Cajal bodies"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1070:FF:000001">
        <property type="entry name" value="Gem-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017364">
        <property type="entry name" value="GEMIN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794:SF0">
        <property type="entry name" value="GEM-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12794">
        <property type="entry name" value="GEMIN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038038">
        <property type="entry name" value="SMN_Gemin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004387.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="283" mass="31813" checksum="F346BD1444B4C966" modified="2022-01-19" version="1">MPVVPATREAEAAGFMAWVPAESAVEELMPRLLPVEPCDLTEAFDPSVPPRTPQEYLRRVQIEAAQCPDVVVAQIDPKKLKRKQSVNISLSGCQPAPEGYSPTLQWQQQQVAQFSTVRQSVNKHRSHWKSQQLDSNVTMPKSEDEEGWKKFCLGERLCAEGAIGPATNESPGIDYVQIGFPPLLSIVSRMNQATVTSVLEYLSNWFGERDFTPELGRWLYALLACLEKPLLPEAHSLIRQLARRCSEVRLLVDSKDDERVPALNLLICLVSRYFDQRIADEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5US64</accession>
    <name>A0A8C5US64_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquinone biosynthesis O-methyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">3-demethylubiquinol 3-O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.64</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">3-demethylubiquinone 3-O-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polyprenyldihydroxybenzoate methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.114</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">COQ3</name>
        <name evidence="11" type="synonym">LOC105856863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3,4-dihydroxy-5-(all-trans-decaprenyl)benzoate + S-adenosyl-L-methionine = 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoate + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:62793"/>
            <dbReference type="ChEBI" id="CHEBI:62796"/>
            <dbReference type="EC" id="2.1.1.114"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64182"/>
            <dbReference type="ChEBI" id="CHEBI:64183"/>
            <dbReference type="EC" id="2.1.1.64"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 3-demethylubiquinone + S-adenosyl-L-methionine = a ubiquinone + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:81215"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:19654"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:231825"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.64" evidence="10"/>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="2.1.1.114" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03007718">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007719">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5US64"/>
    <dbReference type="Ensembl" id="ENSMICT00000006813.3">
        <property type="protein sequence ID" value="ENSMICP00000006208.2"/>
        <property type="gene ID" value="ENSMICG00000006818.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007284"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110142">
        <property type="term" value="C:ubiquinone biosynthesis complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120537">
        <property type="term" value="F:3-demethylubiquinone 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000142">
        <property type="entry name" value="Ubiquinone biosynthesis O-methyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00472">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 10" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006208.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="370" mass="41285" checksum="F1A5354DDF78CF49" modified="2022-01-19" version="1">MWGGGKLSYSGARFLGVLVPGWRSSQTKCPGLTSLAVYSKNQLNWSLEIKPGVFNEYRTMWFKSYRTAFSCLNRMKSYRSPWTRLYSTSQNTVDSNEVKTFLALAHKWWDEQGVYAPLHSMNDLRVPFIRDNLLKTVANHQPGKPLSGMKILDVGCGGGLLTEPLGRLGASVVGIDPVDENIKTAQCHKSFDPVLDQRIEYRACSLEEIVEDTAETFDAVVASEVVEHVLDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIAGIVPKGTHTWEKFVSPEKLESILEPNGLSVQTVAGMLYNPFSGHWHWSENTSLNYAAHAVKSTVQEHTVPAEFVLKEETEELQANAYTSPGMHEELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5USN9</accession>
    <name>A0A8C5USN9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Growth arrest specific 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">GAS7</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020602">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020603">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5USN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000005375.3">
        <property type="protein sequence ID" value="ENSMICP00000004901.3"/>
        <property type="gene ID" value="ENSMICG00000005373.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156268"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048812">
        <property type="term" value="P:neuron projection morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07649">
        <property type="entry name" value="F-BAR_GAS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000024">
        <property type="entry name" value="growth arrest-specific protein 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037957">
        <property type="entry name" value="GAS7_F-BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF57">
        <property type="entry name" value="GROWTH ARREST-SPECIFIC PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16623">
        <property type="entry name" value="WW_FCH_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="94"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004901.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="374" mass="43002" checksum="AECE4F377C3DEFA9" modified="2022-01-19" version="1">TTWERPSSSPGIPASPGPHRSSLPPTVNGYHASGTPAHPPETAHMSLRKSTGDSQNLGSSSPSKKQSKENTITINCVTFPHPDTMPEQQLLKPTEWSYCDYFWADKKDPQGNGTVAGFELLLQKQLKGKQMQKEMSEFIRERIKIEEDYAKNLAKLSQNSLAAQEEGSLGEAWAQVKKSLADEAEVHLKFSAKLHSEVEKPLMNFRENFKKDMKKCDHHIADLRKQLASRYASVEKARKALTERQRDLEMKTQQLEIKLSNKTEEDIKKARRKSTQAGDDLMRCVDLYNQAQSKWFEEMVTTTLELERLEVERVEMIRQHLCQYTQLRHETDMFNQSTVEPVDQLLRKVDPAKDRELWVREHKTGNIRPVDMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UU00</accession>
    <name>A0A8C5UU00_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deaminated glutathione amidase</fullName>
            <ecNumber evidence="3">3.5.1.128</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nitrilase homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NIT1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.128" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03003090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624018.1">
        <property type="nucleotide sequence ID" value="XM_012768564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UU00"/>
    <dbReference type="Ensembl" id="ENSMICT00000007240.3">
        <property type="protein sequence ID" value="ENSMICP00000006593.3"/>
        <property type="gene ID" value="ENSMICG00000007241.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873542"/>
    <dbReference type="CTD" id="4817"/>
    <dbReference type="GeneTree" id="ENSGT00550000075099"/>
    <dbReference type="OrthoDB" id="680339at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110050">
        <property type="term" value="F:deaminated glutathione amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000005">
        <property type="entry name" value="nitrilase homolog 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006593.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="34257" checksum="467B11207253D9F7" modified="2022-01-19" version="1">MTFELPKRLAEEKGFSLMPRAMASSSSWELPLVAVCQVTSTPDKQQNFKTCAELVREAARLGACLAFLPEAFDFIARDPAETLYLSEPLGGNLLGEYTQLARECGLWLSLGGFHERGQDWEQTQKIYNCHVILNSKGSVVATYRKTHLCDVEIPGQGPMRESNSTMPGPSLESPVDTPAGKIGLAVCYDMRFPELSLALAQAGAEILTYPSAFGSVTGPAHWEVLLRARAIETQCYVVAAAQCGRHHEKRASYGHSMVVDPWGTVVARCSEGPGLCLARIDLNYLRQLRQHLPVFQHRRPDLYGNLGHPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVJ3</accession>
    <name>A0A8C5UVJ3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin tyrosine ligase like 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TTLL6</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin--tyrosine ligase family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012766045.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000007548.3">
        <property type="protein sequence ID" value="ENSMICP00000006870.3"/>
        <property type="gene ID" value="ENSMICG00000007549.3"/>
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    <dbReference type="KEGG" id="mmur:105872184"/>
    <dbReference type="CTD" id="284076"/>
    <dbReference type="GeneTree" id="ENSGT00940000161434"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097731">
        <property type="term" value="C:9+0 non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003353">
        <property type="term" value="P:positive regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060296">
        <property type="term" value="P:regulation of cilium beat frequency involved in ciliary motility"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF96">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006870.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Rho GTPase activating protein 30</fullName>
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        <name evidence="4" type="primary">ARHGAP30</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0035024">
        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000002">
        <property type="entry name" value="rho GTPase-activating protein 32 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
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    <dbReference type="PANTHER" id="PTHR15729">
        <property type="entry name" value="CDC42 GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15729:SF12">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="495"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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    <feature type="compositionally biased region" description="Pro residues" evidence="2">
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            <end position="951"/>
        </location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006572.3"/>
        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1A4</accession>
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        <recommendedName>
            <fullName evidence="7">Outer dynein arm-docking complex subunit 4</fullName>
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        <alternativeName>
            <fullName evidence="8">Tetratricopeptide repeat protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ODAD4</name>
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    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020164">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1A4"/>
    <dbReference type="Ensembl" id="ENSMICT00000011892.3">
        <property type="protein sequence ID" value="ENSMICP00000010830.3"/>
        <property type="gene ID" value="ENSMICG00000011891.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007911"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097728">
        <property type="term" value="C:9+0 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097729">
        <property type="term" value="C:9+2 motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120228">
        <property type="term" value="C:outer dynein arm docking complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090660">
        <property type="term" value="P:cerebrospinal fluid circulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060287">
        <property type="term" value="P:epithelial cilium movement involved in determination of left/right asymmetry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120197">
        <property type="term" value="P:mucociliary clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120229">
        <property type="term" value="P:protein localization to motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000189">
        <property type="entry name" value="Tetratricopeptide repeat domain 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000274">
        <property type="entry name" value="Tetratricopeptide repeat domain 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040111">
        <property type="entry name" value="ODAD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23040:SF1">
        <property type="entry name" value="OUTER DYNEIN ARM-DOCKING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="360"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="525"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="587"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010830.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="652" mass="74627" checksum="660531A578A294E0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2L1</accession>
    <name>A0A8C5V2L1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1</fullName>
            <ecNumber evidence="10">2.1.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">TAR RNA-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TARBP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 18 (Gm18) in a subset of tRNA. Selectively mediates Gm18 methylation of tRNAGln-TTG/CTG and tRNASer-TGA/GCT. Gm18 modification can enhance the stability of modified tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(18) in tRNA + S-adenosyl-L-methionine = 2'-O-methylguanosine(18) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20077"/>
            <dbReference type="Rhea" id="RHEA-COMP:10190"/>
            <dbReference type="Rhea" id="RHEA-COMP:10192"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="EC" id="2.1.1.34"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:20078"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.34" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03021262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021263">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021266">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000015300.3">
        <property type="protein sequence ID" value="ENSMICP00000013955.3"/>
        <property type="gene ID" value="ENSMICG00000015280.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003939"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141100">
        <property type="term" value="F:tRNA (guanine(18)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000010">
        <property type="entry name" value="probable methyltransferase TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025806">
        <property type="entry name" value="TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056921">
        <property type="entry name" value="TARBP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25050">
        <property type="entry name" value="TARBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51624">
        <property type="entry name" value="SAM_MT_TRMH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TARBP1" evidence="14">
        <location>
            <begin position="268"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="13">
        <location>
            <begin position="1378"/>
            <end position="1519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013955.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1550" mass="174632" checksum="9BC14991F4D8B518" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2Z0</accession>
    <name>A0A8C5V2Z0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC109729770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the large ribosomal subunit (LSU). Part of the 5S RNP complex, which is a LSU subcomplex composed of the 5S RNA, RPL5 and RPL11. Component of a hexameric 5S RNP precursor complex, composed of 5S RNA, RRS1, RPF2/BXDC1, RPL5, RPL11 and HEATR3; this complex acts as a precursor for ribosome assembly. Interacts with PML. Interacts with MDM2 (via its RanBP2-type zinc finger domain); negatively regulates MDM2-mediated TP53 ubiquitination and degradation. Interacts with NOP53; retains RPL11 into the nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2Z0"/>
    <dbReference type="Ensembl" id="ENSMICT00000009572.3">
        <property type="protein sequence ID" value="ENSMICP00000008711.3"/>
        <property type="gene ID" value="ENSMICG00000009582.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000144211"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008711.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="173" mass="19661" checksum="5FA4F7C338143771" modified="2022-01-19" version="1">IMADQGEKENPMQELRIRKLCPNSVLGRVGQTDRQQVLGVRADCVSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V457</accession>
    <name>A0A8C5V457_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">nucleoside-triphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.6.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ENTPD7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>UTP + H2O = UDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:64900"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03019354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623725.1">
        <property type="nucleotide sequence ID" value="XM_012768271.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623736.1">
        <property type="nucleotide sequence ID" value="XM_012768282.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V457"/>
    <dbReference type="Ensembl" id="ENSMICT00000010499.3">
        <property type="protein sequence ID" value="ENSMICP00000009563.3"/>
        <property type="gene ID" value="ENSMICG00000010496.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873392"/>
    <dbReference type="KEGG" id="mmur:105873392"/>
    <dbReference type="CTD" id="57089"/>
    <dbReference type="GeneTree" id="ENSGT01150000286963"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043273">
        <property type="term" value="F:CTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:UDP phosphatase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:CTP catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:GTP metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:nucleobase-containing small molecule catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072539">
        <property type="term" value="P:T-helper 17 cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006256">
        <property type="term" value="P:UDP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046052">
        <property type="term" value="P:UTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd24045">
        <property type="entry name" value="ASKHA_NBD_NTPDase4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000057">
        <property type="entry name" value="Ectonucleoside triphosphate diphosphohydrolase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000003">
        <property type="entry name" value="ectonucleoside triphosphate diphosphohydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF37">
        <property type="entry name" value="ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="261"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009563.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="604" mass="68960" checksum="E641EE02C8816D4A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBI4</accession>
    <name>A0A8C5VBI4_MICMU</name>
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        <submittedName>
            <fullName evidence="10">Dpy-19 like 4</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="12">Probable C-mannosyltransferase DPY19L4 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">DPY19L4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="12">Liver</tissue>
        </source>
    </reference>
    <reference evidence="10" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013200">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013201">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628292.1">
        <property type="nucleotide sequence ID" value="XM_012772838.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBI4"/>
    <dbReference type="Ensembl" id="ENSMICT00000054986.2">
        <property type="protein sequence ID" value="ENSMICP00000016469.1"/>
        <property type="gene ID" value="ENSMICG00000034944.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875663"/>
    <dbReference type="KEGG" id="mmur:105875663"/>
    <dbReference type="CTD" id="286148"/>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF2">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="RefSeq" id="XP_012628292.1"/>
        </source>
    </evidence>
    <sequence length="723" mass="83855" checksum="3403AF0F0BA5CD4D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDZ6</accession>
    <name>A0A8C5VDZ6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 19">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">MCM7</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with the ATR-ATRIP complex and with RAD17. Interacts with TIPIN. Interacts with MCMBP. Interacts with ANKRD17. Component of the replisome complex composed of at least DONSON, MCM2, MCM7, PCNA and TICRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="ABDC03021066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614440.1">
        <property type="nucleotide sequence ID" value="XM_012758986.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDZ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000031093.2">
        <property type="protein sequence ID" value="ENSMICP00000020365.1"/>
        <property type="gene ID" value="ENSMICG00000003969.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868306"/>
    <dbReference type="KEGG" id="mmur:105868306"/>
    <dbReference type="CTD" id="4176"/>
    <dbReference type="GeneTree" id="ENSGT01150000286966"/>
    <dbReference type="OrthoDB" id="3207464at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17758">
        <property type="entry name" value="MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000004">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000007">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000288">
        <property type="entry name" value="DNA replication licensing factor MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="332"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="719" mass="81316" checksum="40DB770B6EF365BB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHW7</accession>
    <name>A0A8C5VHW7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC105856683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014037">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VHW7"/>
    <dbReference type="Ensembl" id="ENSMICT00000047354.2">
        <property type="protein sequence ID" value="ENSMICP00000020082.2"/>
        <property type="gene ID" value="ENSMICG00000029452.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154129"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039694">
        <property type="term" value="P:viral RNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22515">
        <property type="entry name" value="KH-I_PCBP1_2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22518">
        <property type="entry name" value="KH-I_PCBP1_2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000002">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000003">
        <property type="entry name" value="poly(RC)-binding protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="96"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020082.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="286" mass="29976" checksum="10128E4DEDDACD00" modified="2022-01-19" version="1">MDAGVIEGGLNVTLTTRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAGPTNAISKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPANQCGSLIGKGGCKIKEMRESAGAQVQVAGDMLPNSTERAITIAGIPQSIIPCVKQICAVMLETLSQSPPKGVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTKPHQLAVQHGIESSSPEVNGYWGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGALSSETGGMGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VK04</accession>
    <name>A0A8C5VK04_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.155</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MGAT5B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;4)]-alpha-D-Man-(1-&gt;3)-[beta-D-GlcNAc-(1-&gt;2)-[beta-D-GlcNAc-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16921"/>
            <dbReference type="Rhea" id="RHEA-COMP:14374"/>
            <dbReference type="Rhea" id="RHEA-COMP:14377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:139507"/>
            <dbReference type="ChEBI" id="CHEBI:139510"/>
            <dbReference type="EC" id="2.4.1.155"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 18 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.155" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03019858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634373.2">
        <property type="nucleotide sequence ID" value="XM_012778919.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VK04"/>
    <dbReference type="Ensembl" id="ENSMICT00000051285.2">
        <property type="protein sequence ID" value="ENSMICP00000024515.2"/>
        <property type="gene ID" value="ENSMICG00000003382.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105878989"/>
    <dbReference type="CTD" id="146664"/>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="OrthoDB" id="2113294at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030144">
        <property type="term" value="F:alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026116">
        <property type="entry name" value="GT18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052105">
        <property type="entry name" value="MGAT5_Glycosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075:SF6">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLGLYCOPROTEIN 6-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15075">
        <property type="entry name" value="ALPHA-MANNOSIDE BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15024">
        <property type="entry name" value="Glyco_transf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase family 18 catalytic" evidence="15">
        <location>
            <begin position="185"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024515.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="793" mass="89093" checksum="DA236D731E153BB9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VK16</accession>
    <name>A0A8C5VK16_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 230</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C1orf232</name>
        <name evidence="2" type="synonym">LOC105863462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VK16"/>
    <dbReference type="Ensembl" id="ENSMICT00000032452.2">
        <property type="protein sequence ID" value="ENSMICP00000021281.1"/>
        <property type="gene ID" value="ENSMICG00000034667.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105863462"/>
    <dbReference type="GeneTree" id="ENSGT00530000067301"/>
    <dbReference type="OrthoDB" id="9940890at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35663:SF3">
        <property type="entry name" value="GENE, 30191-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35663">
        <property type="entry name" value="TESTIS DEVELOPMENT-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="185" mass="20260" checksum="54EA60BF2CBA95DD" modified="2022-01-19" version="1">MNQAFWKTYKSKVLQTLSGESEEDLTEERENPALVESEKTEPTEEASNAMSQLARRVQGVGVKGWLTMSSLFNKEDEDKLLPPEPCADHPLAARPPSQAAAAEPRGPGFWDAFASRWQQQQAAAASMLRGAEPTAEPDPEPRDEAAEEAAEPPELREADPAAGFKWGFLTHKLAEMRVKAASKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQP9</accession>
    <name>A0A8C5VQP9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ceramide synthase 5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03015178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQP9"/>
    <dbReference type="Ensembl" id="ENSMICT00000034704.2">
        <property type="protein sequence ID" value="ENSMICP00000028103.2"/>
        <property type="gene ID" value="ENSMICG00000026640.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000169926"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028103.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8028" checksum="6A623A91A42DAC4A" modified="2022-01-19" version="1">MATAAAGPLGLLWGWLWSERFWLPQNVSWADLEGPGDGYGYPRAQHIFSAFPVAAGIFSVRLLFERVSLCCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQV0</accession>
    <name>A0A8C5VQV0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sterile alpha motif domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SAMD1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027727">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQV0"/>
    <dbReference type="Ensembl" id="ENSMICT00000052785.2">
        <property type="protein sequence ID" value="ENSMICP00000025975.2"/>
        <property type="gene ID" value="ENSMICG00000030168.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162952"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09583">
        <property type="entry name" value="SAM_Atherin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056983">
        <property type="entry name" value="SAMD1-like_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048589">
        <property type="entry name" value="SAMD1-like_WH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36292:SF2">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36292">
        <property type="entry name" value="UPF0575 PROTEIN C19ORF67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24971">
        <property type="entry name" value="SAMD1_SHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21524">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52014">
        <property type="entry name" value="SAMD1_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAMD1-like winged helix (WH)" evidence="8">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="7">
        <location>
            <begin position="347"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025975.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="423" mass="45126" checksum="34AD497F922CD19A" modified="2022-01-19" version="1">MAGPPALPPPETAAAATTAAAASSSAASPHYQEWILDTIDSLRSRKARPDLERICRMVRRRHGPEPERTRAELEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGAPPAPPRAPQQQPPPPPPATPPPEGGAARAGGPARPVSCGSGGSGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERVLEKEEEDDEDEEEDDEDDVSESSEVPESDRPAGAQHHQLNGERGPQSAKERVKEWSPCGPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGSASVATGPDSPSPVPLPPGKPALPGADGTPFGCPPGRKEKPADPVEWTVMDVVEYFTEAGFPEQATAFQEQEIDGKSLLLMQRTDVLTGLSIRLGPALKIYEHHIKVLQQGHFEDDDPDGFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VR25</accession>
    <name>A0A8C5VR25_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine/tyrosine interacting protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VR25"/>
    <dbReference type="Ensembl" id="ENSMICT00000053414.2">
        <property type="protein sequence ID" value="ENSMICP00000027304.1"/>
        <property type="gene ID" value="ENSMICG00000037859.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154859"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12602" checksum="4B3D3A6B8B5960BC" modified="2022-01-19" version="1">ITKEFIDESLQTGGKVLVHGNAEISRSTAFVTAYIMETFGVKYRDAFTSVQERRFCINSNVGFVHQLQEYEAIYLMMSPLQTERSLSVHSGTTGSLKGTNEEDDDIGNTQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VRE9</accession>
    <name>A0A8C5VRE9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inducible T-cell costimulator</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Activation-inducible lymphocyte immunomediatory molecule</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ICOS</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Homodimer; disulfide-linked. Interacts with ICOSLG. Interacts with PIK3R1. Interacts with TBK1; this interaction is critical for the maturation of T follicular regulatory cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594359.1">
        <property type="nucleotide sequence ID" value="XM_012738905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRE9"/>
    <dbReference type="Ensembl" id="ENSMICT00000035131.2">
        <property type="protein sequence ID" value="ENSMICP00000028617.1"/>
        <property type="gene ID" value="ENSMICG00000037046.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856923"/>
    <dbReference type="KEGG" id="mmur:105856923"/>
    <dbReference type="CTD" id="29851"/>
    <dbReference type="GeneTree" id="ENSGT00390000000801"/>
    <dbReference type="OrthoDB" id="9403189at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031295">
        <property type="term" value="P:T cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002517">
        <property type="term" value="P:T cell tolerance induction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061470">
        <property type="term" value="P:T follicular helper cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000874">
        <property type="entry name" value="Inducible T-cell costimulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039943">
        <property type="entry name" value="ICOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20904:SF0">
        <property type="entry name" value="INDUCIBLE T-CELL COSTIMULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20904">
        <property type="entry name" value="INDUCIBLE T-CELL COSTIMULATOR ICOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15910">
        <property type="entry name" value="V-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150154" description="Inducible T-cell costimulator" evidence="14">
        <location>
            <begin position="21"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="15">
        <location>
            <begin position="23"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF15910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="200" mass="23022" checksum="C8697C5AA358B082" modified="2022-01-19" version="1">MKSDFWCFFLFCFQIEVVAGEINDSANYEMFSFHNGGVKVLCKYPEIVQQFKMQLLKGEQILCDLTKTKESGNAVSIEDLKFCKSQLSNNSVSFFLYNLDSSHTSYYFCKLSIFDPPPFQVGILKREYLHIYESQVCCHLKFWLYLGCAALGVICVLGCLFTFWLTKKKYQSSVHDPNSEYMFMAAVKTAKKPILTDVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VTN5</accession>
    <name>A0A8C5VTN5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Caveolin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CAV3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Cell membrane</location>
            <topology evidence="2 11">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <location evidence="11">Caveola</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the caveolin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028942">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028943">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616158.1">
        <property type="nucleotide sequence ID" value="XM_012760704.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VTN5"/>
    <dbReference type="Ensembl" id="ENSMICT00000049285.2">
        <property type="protein sequence ID" value="ENSMICP00000030063.1"/>
        <property type="gene ID" value="ENSMICG00000035303.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869098"/>
    <dbReference type="KEGG" id="mmur:105869098"/>
    <dbReference type="CTD" id="859"/>
    <dbReference type="GeneTree" id="ENSGT00950000183006"/>
    <dbReference type="OrthoDB" id="5917823at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016010">
        <property type="term" value="C:dystrophin-associated glycoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071253">
        <property type="term" value="F:connexin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003300">
        <property type="term" value="P:cardiac muscle hypertrophy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070836">
        <property type="term" value="P:caveola assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042632">
        <property type="term" value="P:cholesterol homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035995">
        <property type="term" value="P:detection of muscle stretch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060347">
        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051926">
        <property type="term" value="P:negative regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010614">
        <property type="term" value="P:negative regulation of cardiac muscle hypertrophy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045792">
        <property type="term" value="P:negative regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900826">
        <property type="term" value="P:negative regulation of membrane depolarization during cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060299">
        <property type="term" value="P:negative regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051647">
        <property type="term" value="P:nucleus localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010831">
        <property type="term" value="P:positive regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060762">
        <property type="term" value="P:regulation of branching involved in mammary gland duct morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090279">
        <property type="term" value="P:regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098909">
        <property type="term" value="P:regulation of cardiac muscle cell action potential involved in regulation of contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051480">
        <property type="term" value="P:regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900744">
        <property type="term" value="P:regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038009">
        <property type="term" value="P:regulation of signal transduction by receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014819">
        <property type="term" value="P:regulation of skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902305">
        <property type="term" value="P:regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017015">
        <property type="term" value="P:regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060373">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001612">
        <property type="entry name" value="Caveolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018361">
        <property type="entry name" value="Caveolin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10844:SF16">
        <property type="entry name" value="CAVEOLIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01146">
        <property type="entry name" value="Caveolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01210">
        <property type="entry name" value="CAVEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="151" mass="17020" checksum="89BF3E2F84FAD6D9" modified="2022-01-19" version="1">MMAEERSDLEAQIVKDIHFKEIDLVNRDPKNINEDIVKVDFEDVIAEPVGTYSFDGVWKASYTTFTVSKYWCYRLLSTLLGVPLALLWGFLFACISFGHIWAVVPCVKSYLIGVQCASHVYSLCVRTFCNPLFAALGQACGSIKVLLRKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZG0</accession>
    <name>A0A8C5VZG0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING finger protein 150</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RNF150</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03018671">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018672">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639282.1">
        <property type="nucleotide sequence ID" value="XM_012783828.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VZG0"/>
    <dbReference type="Ensembl" id="ENSMICT00000045981.2">
        <property type="protein sequence ID" value="ENSMICP00000032153.2"/>
        <property type="gene ID" value="ENSMICG00000009057.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881872"/>
    <dbReference type="KEGG" id="mmur:105881872"/>
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    <dbReference type="GeneTree" id="ENSGT00940000156171"/>
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        <property type="component" value="Chromosome 14"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RING-H2_RNF150"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase RNF130"/>
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        <property type="entry name" value="Ring finger protein 150"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PA_dom_sf"/>
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        <property type="entry name" value="PA_domain"/>
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    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF27">
        <property type="entry name" value="RING FINGER PROTEIN 128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150194" description="RING finger protein 150" evidence="12">
        <location>
            <begin position="35"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00074816"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032153.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="437" mass="48091" checksum="46AE98AE393E7D20" modified="2022-01-19" version="1">MAMSLIRACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYAEPAPDPAAGGAGGGAELRTEKTECGRYGEHSPKQDARGEVVMASSAHDRLACDPNTKFAAPTHGKNWIALIPKGNCTYRDKIRNAFLQNASAVVIFNVGSNNNETITMPHAGVEDIVAIMIPEPKGREIVSLLERNVTVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISKLQVRTIKKGDKETEPDFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPTDFEGSLGGPPTNQITGASDTTVNESSVTLDPAVRTVGALQVVQDADPTPQEGEVIFTTNSEQEPAVSSDSDISLIMAMEVGLSDVELSTDQDCEEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0F9</accession>
    <name>A0A8C5W0F9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EPC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_012783559.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000034937.2">
        <property type="protein sequence ID" value="ENSMICP00000030803.1"/>
        <property type="gene ID" value="ENSMICG00000033721.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105881717"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155003"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009607">
        <property type="entry name" value="Enhancer_polycomb_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06752">
        <property type="entry name" value="E_Pc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="10">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Enhancer of polycomb C-terminal" evidence="9">
        <location>
            <begin position="581"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="329"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="778"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06752"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="812" mass="90823" checksum="486C66525786F186" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W3H1</accession>
    <name>A0A8C5W3H1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromodomain Y-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CDYL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts (via chromo domain) with histone H3K9me3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W3H1"/>
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        <property type="protein sequence ID" value="ENSMICP00000035978.2"/>
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        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
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        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
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        <property type="entry name" value="CHROMODOMAIN Y-LIKE PROTEIN 2"/>
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    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
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            <begin position="88"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="508" mass="56295" checksum="15F487FB14C927C5" modified="2022-01-19" version="1">MASGDLYEVERIVDKRKNKKGKWEYLIRWKGYGSAEDTWEPEHHLLHCEEFIDEFNGLHVSKEKRVKSGKQPGSSKLLRDGRGPPVEKLAHRPPEPGKSKATSHKRKRINPPLSKLKKGCSGKPPAGGDRAAKTVSYRTTPSGLQIMPLKKAQNGVENGDAGPEKDERHFGNGSHQPGLDLSDQVGEQDVGECDGSHAATLAENGLAGSALTNGGLNLHSPVKRKLDAEKDYVFDKRLRYSVRQNESNCRFRDIVVRKEEGFTHILLSSQTSDNNALTPEIMKEVRRALCNAATDDSKLLLLSAVGSVFCSGLDYSYLIGRLSSDRRKESTRIAEAIRDFVKAFIQFKKPIVVAINGPALGLGASILPLCDIVWASEKAWFQTPYATIRLTPAGCSSYTFPQILGVALANEMLFCGRKLTAQEACSRGLVSQVFWPTTFSQEVMLRVKEMASCSAVVLEESKCLVRSFLKSVLEDVNEKECLMLKQLWSSSKGLDSLFSYLQDKIYEV</sequence>
</entry>
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    <accession>A0A8C5W4S0</accession>
    <name>A0A8C5W4S0_MICMU</name>
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        <submittedName>
            <fullName evidence="2">Ring finger protein 148</fullName>
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        <name evidence="2" type="primary">RNF148</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5034702740" evidence="1">
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            <begin position="35"/>
            <end position="102"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033575.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="102" mass="11547" checksum="B2E085C52DF9958F" modified="2022-01-19" version="1">MNLLRITPSTHSSFSYQLLRLSIFLLLSLPDSKGKAIWTAHLNITFQGTENIVAVMIGNLKGMELLHLIKKGVYVTIIIEVGRMHMPWEAKTDKGGCEESYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W4X2</accession>
    <name>A0A8C5W4X2_MICMU</name>
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        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC105862225</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000042114.2">
        <property type="protein sequence ID" value="ENSMICP00000033300.1"/>
        <property type="gene ID" value="ENSMICG00000033947.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000977"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="199" mass="22007" checksum="9D0A87045CC572F8" modified="2022-01-19" version="1">MPVAVMAETCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHLWSETVQPIMEALRDATRRRGFALVSQAHTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPDEQQLARLTDYVAFLEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W508</accession>
    <name>A0A8C5W508_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat domain 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TTC13</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021241">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593648.1">
        <property type="nucleotide sequence ID" value="XM_012738194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W508"/>
    <dbReference type="Ensembl" id="ENSMICT00000050112.2">
        <property type="protein sequence ID" value="ENSMICP00000035207.1"/>
        <property type="gene ID" value="ENSMICG00000004208.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856442"/>
    <dbReference type="KEGG" id="mmur:105856442"/>
    <dbReference type="CTD" id="79573"/>
    <dbReference type="GeneTree" id="ENSGT00940000158461"/>
    <dbReference type="OrthoDB" id="1926212at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44523">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44523:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044491665" evidence="2">
        <location>
            <begin position="38"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="249"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="317"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="351"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="860" mass="96896" checksum="889A4ABFF6E4F229" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W511</accession>
    <name>A0A8C5W511_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetraspanin-31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TSPAN31</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632582.1">
        <property type="nucleotide sequence ID" value="XM_012777128.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W511"/>
    <dbReference type="Ensembl" id="ENSMICT00000038630.2">
        <property type="protein sequence ID" value="ENSMICP00000033962.1"/>
        <property type="gene ID" value="ENSMICG00000003778.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877996"/>
    <dbReference type="KEGG" id="mmur:105877996"/>
    <dbReference type="CTD" id="6302"/>
    <dbReference type="GeneTree" id="ENSGT00940000160351"/>
    <dbReference type="OrthoDB" id="5845060at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF3">
        <property type="entry name" value="TETRASPANIN-31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="129"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="210" mass="23015" checksum="97692B10EA6DB42C" modified="2022-01-19" version="1">MVCGGFACSKNALCALNVVYMLVGLLLIGVAAWGKGLGLVSSIHIIGGVIAVGVFLLLIAVAGLVGAVNHHQVLLFFYMIILGLVFIFQFGISCSCLAINRSKQTDVINASWWVMSNKTRDELERSFDCCGLFNFTTLYQQDYDFCTAICKSKSPTCQMCGEKFLKHSDEALKILGGVGLFFSFTEILGVWLAMRFRNQKDPRANPSAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W970</accession>
    <name>A0A8C5W970_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">plus-end-directed kinesin ATPase</fullName>
            <ecNumber evidence="17">5.6.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">KIF1A</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + a kinesin associated with a microtubule at position (n) = ADP + phosphate a kinesin associated with a microtubule at position (n+1, toward the plus end).</text>
            <dbReference type="EC" id="5.6.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.3" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03010543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000034909.2">
        <property type="protein sequence ID" value="ENSMICP00000034709.2"/>
        <property type="gene ID" value="ENSMICG00000034158.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156474"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000023">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000001">
        <property type="entry name" value="Kinesin family member 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000004">
        <property type="entry name" value="Kinesin-like protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF2">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1A ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11 18" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Kinesin motor" evidence="23">
        <location>
            <begin position="5"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="22">
        <location>
            <begin position="524"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="21">
        <location>
            <begin position="1675"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="589"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="889"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1506"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1617"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="901"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1509"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1627"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="103"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034709.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1790" mass="200439" checksum="8E99841E8BD33D7F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAP0</accession>
    <name>A0A8C5WAP0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DEP domain-containing protein 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DEPDC1B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03016543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631094.1">
        <property type="nucleotide sequence ID" value="XM_012775640.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WAP0"/>
    <dbReference type="Ensembl" id="ENSMICT00000052248.2">
        <property type="protein sequence ID" value="ENSMICP00000037078.1"/>
        <property type="gene ID" value="ENSMICG00000013552.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877265"/>
    <dbReference type="KEGG" id="mmur:105877265"/>
    <dbReference type="CTD" id="55789"/>
    <dbReference type="GeneTree" id="ENSGT00950000182976"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04447">
        <property type="entry name" value="DEP_BRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04405">
        <property type="entry name" value="RhoGAP_BRCC3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000182">
        <property type="entry name" value="DEP domain-containing protein 1B isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000029">
        <property type="entry name" value="DEP domain-containing protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206">
        <property type="entry name" value="DEP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16206:SF11">
        <property type="entry name" value="DEP DOMAIN-CONTAINING PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GTPase activation domain, GAP"/>
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        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="201"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00069595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="529" mass="61939" checksum="88ABD1020E6B64AC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDA8</accession>
    <name>A0A8C5XDA8_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Ankyrin repeat domain 46</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ANKRD46</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03013273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDA8"/>
    <dbReference type="Ensembl" id="ENSMICT00000010224.3">
        <property type="protein sequence ID" value="ENSMICP00000009310.2"/>
        <property type="gene ID" value="ENSMICG00000038072.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157094"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039323">
        <property type="entry name" value="ANKRD_45/46/60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22677:SF4">
        <property type="entry name" value="USHER SYNDROME TYPE-1G PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009310.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="222" mass="24747" checksum="EBE88A2A4D80D653" modified="2022-01-19" version="1">MSYVFVNDSSQTNVPLLQACIDGDFNYSKWLLESGFDPNIRDSRGRTGLHLAAARGNVDICQLLHKFGADLLATDYQGNTALHLCGHVDTIQFLVSNGLKIDICNHQGATPLVLAKRRGVNKDVIRLLESLEEQEVKGFNRGTHSKLETMQTAESESAMESHSLLNPNLQQGEGVLSSFRTTWQEFVEDLGFWRVLLLIFVIALMSLGIAYYVRSRLVSFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDI3</accession>
    <name>A0A8C5XDI3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosylmethionine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDI3"/>
    <dbReference type="Ensembl" id="ENSMICT00000011317.3">
        <property type="protein sequence ID" value="ENSMICP00000010306.2"/>
        <property type="gene ID" value="ENSMICG00000011320.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011776"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019810">
        <property type="term" value="F:putrescine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010306.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="33043" checksum="517CEEB63AF259E0" modified="2022-01-19" version="1">MEAAHFYEGTEKLLEVWFSRQQPDTNQGSGDLCTVPRSERDILLKDVVTKTDKQEAYVVSESSMFVSKRPFILKTCGATLLLKAPVPLLKLARDYSGFDSIQSFFYSRYPRRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLHTLDFPESRVVSQPDQTLEILMSELDPAAMDQFYMKDGATAKDVTRESGIRDLIPGSVIDATLFNPCGFETNLSQTSYDDLIRKVVEVFKPGKCVTTLFVNQSSKCHTVLASPQKIEGFKRLDCQSAMFNGYNFVFTSFAKKQQQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEE4</accession>
    <name>A0A8C5XEE4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase-like oxidoreductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SCCPDH</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021206">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021207">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEE4"/>
    <dbReference type="Ensembl" id="ENSMICT00000014593.3">
        <property type="protein sequence ID" value="ENSMICP00000013305.2"/>
        <property type="gene ID" value="ENSMICG00000014588.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105863754"/>
    <dbReference type="GeneTree" id="ENSGT00390000004799"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000178">
        <property type="entry name" value="Saccharopine dehydrogenase-like oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00039852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013305.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="429" mass="47402" checksum="7594625E09159756" modified="2022-01-19" version="1">MATEQRPFHLVVFGASGFTGQFVTEEVAREQADPERSSQLPWAVAGRCRERLQRVLERAATKLGRPTLLSEVGIIICDITNPASLDEMAKQATIVLNCVGPYRFYGEPVVKACIENGTSCVDICGEPQFLELMKWKYHEKAAEKGVYIIGSSGFDSIPADLGVIYTRNKMNGTLTAVESFLTIQTGPEGLCIHDGTWKSAIYSLGDQSNLRKLRHASNLKPLPIVGPKLKRRWPISFCRELNVYSIPFLGSDVSVVKRTQRYLHENFEESPVQYAAYITVGGITSVIKLMFAGLFFLFFVRFGIGRQLLIKFPWLFSFGYFSKQGPTQKQIDASSFTLTFFGQGYSQGVSTDKNKPNIRICTQVKGPEAGYVATPIAMVQAAMTLLNDVSDLPKAGGVFTPGAAFSKTKLIDRLNKHGIEFSVISSSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEG0</accession>
    <name>A0A8C5XEG0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">hexokinase</fullName>
            <ecNumber evidence="6">2.7.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HKDC1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17825"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17826"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.1" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03018927">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618110.1">
        <property type="nucleotide sequence ID" value="XM_012762656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEG0"/>
    <dbReference type="Ensembl" id="ENSMICT00000014983.3">
        <property type="protein sequence ID" value="ENSMICP00000013663.2"/>
        <property type="gene ID" value="ENSMICG00000014978.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870210"/>
    <dbReference type="KEGG" id="mmur:105870210"/>
    <dbReference type="CTD" id="80201"/>
    <dbReference type="GeneTree" id="ENSGT00950000182787"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00242"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:fructokinase activity"/>
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        <property type="term" value="P:glycolytic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:intracellular glucose homeostasis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ASKHA_NBD_HKDC1_meta_rpt1"/>
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        <property type="entry name" value="Hexokinase 1"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Hexokinase 1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
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        <property type="entry name" value="HEXOKINASE"/>
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    </dbReference>
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        <property type="entry name" value="HEXOKINASE HKDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="18">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="19">
        <location>
            <begin position="226"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="18">
        <location>
            <begin position="470"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="19">
        <location>
            <begin position="672"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="917" mass="102175" checksum="EE9522AE64C1A013" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XF57</accession>
    <name>A0A8C5XF57_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Mitochondrial ribosomal protein S35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">MRPS35</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000017686.3">
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        <property type="gene ID" value="ENSMICG00000017686.3"/>
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        <property type="component" value="Chromosome 21"/>
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        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:mitochondrial translation"/>
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        <property type="entry name" value="Ribosomal_mS35_mit"/>
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        <property type="entry name" value="Ribosomal_mS35_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13490">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016105.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="319" mass="36328" checksum="653A463B5956DC69" modified="2022-01-19" version="1">MAAAALTAWLALHPGVRTLRAFSTAVSPATPSLPERTSKTERMWKRKALPPRTEKMAVDQDWPSVYPAAAPFKPSVVPLPIRMGYPVKKGVPLAKEGNLELLKIPNFLHLTPVAIKRHCEALKEFCTEWPAALDSDEKCEKHFPIEIDTADYVSSGPSIRNPKARVVTLRVKLSSLNLDDHAKKKLIKLVGERYCKTTDVLTIKTDRCPLTRQNYDYAMYLLTVLYHESWKTEEWEKHKTEADMEEYVWENSSSEKNILETLLQIKAAEKTTDVNEEELLGTKEVEDYKNCVVTLKNEGENENTLSQYKESVKRLLNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XH61</accession>
    <name>A0A8C5XH61_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">14 kDa phosphohistidine phosphatase</fullName>
            <ecNumber evidence="5">3.9.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Phosphohistidine phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein histidine phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PHPT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits phosphohistidine phosphatase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(pros)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47964"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(tele)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47960"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:10719"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="3.9.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the janus family.</text>
    </comment>
    <dbReference type="EC" id="3.9.1.3" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03015026">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015027">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XH61"/>
    <dbReference type="Ensembl" id="ENSMICT00000051179.2">
        <property type="protein sequence ID" value="ENSMICP00000022010.1"/>
        <property type="gene ID" value="ENSMICG00000029117.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002738"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.20.20:FF:000001">
        <property type="entry name" value="14 kDa phosphohistidine phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.20.20">
        <property type="entry name" value="Janus/Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007702">
        <property type="entry name" value="Janus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038596">
        <property type="entry name" value="Janus_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258:SF10">
        <property type="entry name" value="14 KDA PHOSPHOHISTIDINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12258">
        <property type="entry name" value="JANUS-A/JANUS-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05005">
        <property type="entry name" value="Ocnus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143724">
        <property type="entry name" value="PHP14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR607702-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="126" mass="14129" checksum="3000A37F2B328169" modified="2022-01-19" version="1">MAAASLAQIPDVDIDSDGVFKYVLIRVHLAPPSGSPAAESKEIVRGYKWAEYHADIYDKVSSEIQKQGYDCECLGGGRISHQSQDKKIHVYGYSMVRLRPCQHSVSTEKIKAKYPDYEVTWADDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XIB5</accession>
    <name>A0A8C5XIB5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Capping protein regulator and myosin 1 linker 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CARMIL2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CARMIL family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024313">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000033598.2">
        <property type="protein sequence ID" value="ENSMICP00000025431.2"/>
        <property type="gene ID" value="ENSMICG00000012140.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161003"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044354">
        <property type="term" value="C:macropinosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061339">
        <property type="term" value="P:establishment or maintenance of monopolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000813">
        <property type="term" value="P:negative regulation of barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090091">
        <property type="term" value="P:positive regulation of extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010592">
        <property type="term" value="P:positive regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900029">
        <property type="term" value="P:positive regulation of ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034315">
        <property type="term" value="P:regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044319">
        <property type="term" value="P:wound healing, spreading of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000009">
        <property type="entry name" value="F-actin-uncapping protein LRRC16A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031943">
        <property type="entry name" value="CARMIL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041245">
        <property type="entry name" value="CARMIL_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051279">
        <property type="entry name" value="PP1-Reg/Actin-Interact_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112:SF32">
        <property type="entry name" value="CAPPING PROTEIN, ARP2_3 AND MYOSIN-I LINKER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24112">
        <property type="entry name" value="LEUCINE-RICH REPEAT, ISOFORM F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17888">
        <property type="entry name" value="Carm_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16000">
        <property type="entry name" value="CARMIL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CARMIL pleckstrin homology" evidence="11">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="CARMIL C-terminal" evidence="10">
        <location>
            <begin position="807"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="920"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="955"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1213"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1267"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1396"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025431.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1418" mass="153120" checksum="D2B4ED9F23A08BFA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJ57</accession>
    <name>A0A8C5XJ57_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTPase, IMAP family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GIMAP4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015112">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641591.1">
        <property type="nucleotide sequence ID" value="XM_012786137.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJ57"/>
    <dbReference type="Ensembl" id="ENSMICT00000030834.2">
        <property type="protein sequence ID" value="ENSMICP00000027716.1"/>
        <property type="gene ID" value="ENSMICG00000038028.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105883163"/>
    <dbReference type="KEGG" id="mmur:105883163"/>
    <dbReference type="CTD" id="55303"/>
    <dbReference type="GeneTree" id="ENSGT00940000159317"/>
    <dbReference type="OrthoDB" id="5985928at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF182">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="6">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="225"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="324" mass="36816" checksum="EF39A7461A6D16CE" modified="2022-01-19" version="1">MATQYHGTSSSPGGHPANSHELGSQLRIVLVGRTGAGKSATGNSILGEKVFNSGIAAKSITKTCEKRSGRWEETELVVVDTPGIFDTETPDEDISKEIVRCILLTSPGPHALLLVVPLGRYTEEEHEATQKILKMFGDRARKFMTLLFTRKDDLGDISFHDYLQEAPKGIQELLSTFGGRYCVFNNRATGAEQEAQRAQLLALLQRMGRENGGGCYTNKLYGRAEQEIQKQIQVLQEKYRAELEREKAQIREEYESIIRNLRDKLEQEKRKANMERQLAEREDFYAARQQAARREVEGQKDIIEFIFNLLNVAYHIFSRIFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XMG1</accession>
    <name>A0A8C5XMG1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDGSH iron sulfur domain 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CISD3</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ABDC03020128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XMG1"/>
    <dbReference type="Ensembl" id="ENSMICT00000036847.2">
        <property type="protein sequence ID" value="ENSMICP00000037394.1"/>
        <property type="gene ID" value="ENSMICG00000030046.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004574"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.90:FF:000003">
        <property type="entry name" value="CDGSH iron sulfur domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.90:FF:000002">
        <property type="entry name" value="CDGSH iron-sulfur domain-containing protein 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052950">
        <property type="entry name" value="CISD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491">
        <property type="entry name" value="CDGSH IRON SULFUR DOMAIN PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46491:SF3">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="6">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="127" mass="14115" checksum="F1D1F32A113B12AC" modified="2022-01-19" version="1">VSGVGAMLRPAARGAWNLNQRRDISSWLARWFPKTPAKSVVALKTPIKVELVAGKTYRWCVCGHSKKQPFCDGSHFFQRTGLSPLKFKAQETRTVALCTCKATQKPPYCDGTHRSERVQKAEVGSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQU7</accession>
    <name>A0A8C5XQU7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger homeobox protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Zinc finger homeodomain protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ZFHX4</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May play a role in neural and muscle differentiation. May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18 19">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012957">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594632.1">
        <property type="nucleotide sequence ID" value="XM_012739178.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594633.1">
        <property type="nucleotide sequence ID" value="XM_012739179.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000029332.2">
        <property type="protein sequence ID" value="ENSMICP00000039608.2"/>
        <property type="gene ID" value="ENSMICG00000008252.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857064"/>
    <dbReference type="KEGG" id="mmur:105857064"/>
    <dbReference type="CTD" id="79776"/>
    <dbReference type="GeneTree" id="ENSGT00940000159542"/>
    <dbReference type="OrthoDB" id="6417226at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000082">
        <property type="entry name" value="Putative zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000317">
        <property type="entry name" value="zinc finger homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000429">
        <property type="entry name" value="Zinc finger homeobox protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000058">
        <property type="entry name" value="zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000064">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000096">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000081">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001440">
        <property type="entry name" value="Zinc finger homeobox protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051968">
        <property type="entry name" value="ZnFinger_Homeobox_TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45891:SF2">
        <property type="entry name" value="ZINC FINGER HOMEOBOX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24056">
        <property type="entry name" value="zf-C2H2_ZFHX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 18 19" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 18 19" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="1397"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="1425"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="1541"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="1593"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="1948"/>
            <end position="1976"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="21">
        <location>
            <begin position="2128"/>
            <end position="2188"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="21">
        <location>
            <begin position="2225"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="2313"/>
            <end position="2342"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="21">
        <location>
            <begin position="2603"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="22">
        <location>
            <begin position="2675"/>
            <end position="2703"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="21">
        <location>
            <begin position="2928"/>
            <end position="2988"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="18">
        <location>
            <begin position="2130"/>
            <end position="2189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="18">
        <location>
            <begin position="2227"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="18">
        <location>
            <begin position="2605"/>
            <end position="2664"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="18">
        <location>
            <begin position="2930"/>
            <end position="2989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="425"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="563"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1113"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1299"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1492"/>
            <end position="1525"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1858"/>
            <end position="1900"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1995"/>
            <end position="2070"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2335"/>
            <end position="2357"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2372"/>
            <end position="2476"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2555"/>
            <end position="2610"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2809"/>
            <end position="2857"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2875"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="3116"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="3328"/>
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    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="3493"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="9"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
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    <feature type="compositionally biased region" description="Pro residues" evidence="20">
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    <feature type="compositionally biased region" description="Pro residues" evidence="20">
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    <feature type="compositionally biased region" description="Low complexity" evidence="20">
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    <feature type="compositionally biased region" description="Pro residues" evidence="20">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="3176"/>
            <end position="3185"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
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    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039608.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="3617" mass="398257" checksum="A9063E4B3D60AB55" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XT98</accession>
    <name>A0A8C5XT98_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myelin protein P0</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Myelin peripheral protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Myelin protein zero</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MPZ</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer and homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin P0 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XT98"/>
    <dbReference type="Ensembl" id="ENSMICT00000063050.1">
        <property type="protein sequence ID" value="ENSMICP00000040890.1"/>
        <property type="gene ID" value="ENSMICG00000007313.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234556"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042552">
        <property type="term" value="P:myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05879">
        <property type="entry name" value="IgV_P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000193">
        <property type="entry name" value="Myelin protein zero-like 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000920">
        <property type="entry name" value="Myelin_P0-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047014">
        <property type="entry name" value="Myelin_P0_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019566">
        <property type="entry name" value="MYP0_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869">
        <property type="entry name" value="MYELIN P0 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13869:SF7">
        <property type="entry name" value="MYELIN PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10570">
        <property type="entry name" value="Myelin-PO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00213">
        <property type="entry name" value="MYELINP0"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034641348" description="Myelin protein P0" evidence="17">
        <location>
            <begin position="30"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="247" mass="27683" checksum="CFA173E2134C1465" modified="2022-01-19" version="1">AATRTRRPPAQDNAPLFLVSALVLSPAQAIVVYTDREVHGAVGSRVTLHCSFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDYSDNGTFTCDVKNPPDIVGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLALLLFYLVRYCWLRRQAALQRRLSAMEKGKLHKTGKDTKRGRQTPVLYAMLDHTRSAKTASEKKAKGLGESRKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUR6</accession>
    <name>A0A8C5XUR6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Charged multivesicular body protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016023">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUR6"/>
    <dbReference type="Ensembl" id="ENSMICT00000060484.1">
        <property type="protein sequence ID" value="ENSMICP00000041752.1"/>
        <property type="gene ID" value="ENSMICG00000047649.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165316"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904930">
        <property type="term" value="C:amphisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061952">
        <property type="term" value="P:midbody abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071985">
        <property type="term" value="P:multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901673">
        <property type="term" value="P:regulation of mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046761">
        <property type="term" value="P:viral budding from plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039702">
        <property type="term" value="P:viral budding via host ESCRT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="21632" checksum="4A17EF9046E0C174" modified="2022-01-19" version="1">MKPQKTKDSQSHPEQQQKSWRYSNQNSMKVKKNIYTFLHSMAKERIRSRKAVSKLYASKAHVNSVLMGMKNQLAVLRVAGPLQKSTEVMKIPEIQATMQELSKEMMKAGIIEEMLEDTFESMDDQEEMEEAEMEIDKILFEITTGALGKAPSKVTDALPETEPEGAMAASEDEEEEEALEAMQSRLATLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XX47</accession>
    <name>A0A8C5XX47_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein eL33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60S ribosomal protein L35a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105885300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XX47"/>
    <dbReference type="Ensembl" id="ENSMICT00000059585.1">
        <property type="protein sequence ID" value="ENSMICP00000042842.1"/>
        <property type="gene ID" value="ENSMICG00000047403.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016972"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000005">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="110" mass="12587" checksum="B794FB96A25E7F88" modified="2022-01-19" version="1">MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTRAYGHSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXF9</accession>
    <name>A0A8C5XXF9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Telomeric repeat-binding factor 2-interacting protein 1</fullName>
            <shortName evidence="10">TERF2-interacting telomeric protein 1</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Repressor/activator protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TERF2IP</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024141">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024142">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012627983.1">
        <property type="nucleotide sequence ID" value="XM_012772529.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000042747.1"/>
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    </dbReference>
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        <property type="component" value="Chromosome 20"/>
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        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="rap1_RCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2170:FF:000001">
        <property type="entry name" value="Telomeric repeat-binding factor 2-interacting protein 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Telomeric repeat-binding factor 2-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021661">
        <property type="entry name" value="Rap1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038104">
        <property type="entry name" value="Rap1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11626">
        <property type="entry name" value="Rap1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="3 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BRCT" evidence="14">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="12">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="TRF2-interacting telomeric protein/Rap1 C-terminal" evidence="13">
        <location>
            <begin position="318"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
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            <begin position="196"/>
            <end position="244"/>
        </location>
    </feature>
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        <location>
            <begin position="264"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017805"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF16589"/>
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        <source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="395" mass="43719" checksum="FCA704F3FA7A229D" modified="2022-01-19" version="1">MAETMDLGKDPNGPTHSSTLFVREDGSSMSFYVRPSPAKRRLSTLILHGGGTLCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNEKLELEAYRLGPSSAADQTPETTPGALAEGAAEPEPQPTAGRIAFTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEEYVKEEIKENEEAVKKMLVEATREFEEAVVDESPDFEIHITMCDDDPPTPEEDSETQPDEEEEEKASPPEVAAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSSFLASGHRADGYPIWSRQDDIDLQKSDEDTRNALVKKFGAQNVARRIEFRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXR5</accession>
    <name>A0A8C5XXR5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclin-dependent kinase 5 activator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CDK5R1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4. Interacts with RASGRF2. The complex p35/CDK5 interacts with CLOCK.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer of a catalytic subunit and a regulatory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Neuron projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 18">Belongs to the cyclin-dependent kinase 5 activator family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019939">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591148.1">
        <property type="nucleotide sequence ID" value="XM_012735694.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXR5"/>
    <dbReference type="Ensembl" id="ENSMICT00000062577.1">
        <property type="protein sequence ID" value="ENSMICP00000042655.1"/>
        <property type="gene ID" value="ENSMICG00000042797.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105855005"/>
    <dbReference type="KEGG" id="mmur:105855005"/>
    <dbReference type="CTD" id="8851"/>
    <dbReference type="GeneTree" id="ENSGT00390000008812"/>
    <dbReference type="OMA" id="QHCNQNQ"/>
    <dbReference type="OrthoDB" id="7676799at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016533">
        <property type="term" value="C:protein kinase 5 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035255">
        <property type="term" value="F:ionotropic glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007413">
        <property type="term" value="P:axonal fasciculation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:ephrin receptor signaling pathway"/>
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        <property type="term" value="P:G1 to G0 transition involved in cell differentiation"/>
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        <property type="term" value="P:hippocampus development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:layer formation in cerebral cortex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007158">
        <property type="term" value="P:neuron cell-cell adhesion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neuron migration"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of protein targeting to membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of dendritic spine morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:superior olivary nucleus maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Cyclin-dependent kinase 5 activator"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR004944">
        <property type="entry name" value="CDK5_activator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401">
        <property type="entry name" value="CYCLIN DEPENDANT KINASE-5 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23401:SF2">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5 ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03261">
        <property type="entry name" value="CDK5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009324">
        <property type="entry name" value="Cdk5_activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR009324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="306" mass="34015" checksum="5A3373108A618549" modified="2022-01-19" version="1">MGTVLSLSPSYRKATLFEDGAATVGHYTAVQNSKNAKDKNLKRHSIISVLPWKRIVAVSAKKKNSKKVQPNSSYQNNITHLNNENLKKSLSCANLSTFAQPPPAQPPAPPASQLSGSQTGVSSVKKAPHPAVTSAGTPKRVIVQASTSELLRCLGEFLCRRCYRLKHLSPTDPVLWLRSVDRSLLLQGWQDQGFITPANVVFLYMLCRDVISSEVGSDHELQAVLLTCLYLSYSYMGNEISYPLKPFLVESCKEAFWDRCLSVINLMSSKMLQINADPHYFTQVFSDLKNESGQEDKKRLLLGLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XY01</accession>
    <name>A0A8C5XY01_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 783</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF783</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XY01"/>
    <dbReference type="Ensembl" id="ENSMICT00000062418.1">
        <property type="protein sequence ID" value="ENSMICP00000042763.1"/>
        <property type="gene ID" value="ENSMICG00000047374.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162942"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000363">
        <property type="entry name" value="Zinc finger protein 239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000496">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24381:SF269">
        <property type="entry name" value="ZINC FINGER PROTEIN 398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="469"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="237"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="307"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="549" mass="59862" checksum="7E510FFB134B7EFB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XY15</accession>
    <name>A0A8C5XY15_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Signaling threshold regulating transmembrane adaptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SIT1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XY15"/>
    <dbReference type="Ensembl" id="ENSMICT00000070456.1">
        <property type="protein sequence ID" value="ENSMICP00000042971.1"/>
        <property type="gene ID" value="ENSMICG00000041425.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016476"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050863">
        <property type="term" value="P:regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033269">
        <property type="entry name" value="Sit1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15604">
        <property type="entry name" value="SIGNALING THRESHOLD-REGULATING TRANSMEMBRANE ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15604:SF0">
        <property type="entry name" value="SIGNALING THRESHOLD-REGULATING TRANSMEMBRANE ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034331019" evidence="2">
        <location>
            <begin position="24"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="199" mass="21364" checksum="AE942A71719DAD0A" modified="2022-01-19" version="1">MNGTYPWLWAVLVDLALTSAVMSGGCNCTDLPWLATGIPSIGWAWGLWALLGAVTLLLLISLAAHLFQWISGWGRGHLRQGRSGGSVEEVPLYGNLHYLQTGRLNQEPGPDQQDLTPGGPARAAEEVTCYTSLQLRPPQGRIPTPGTPIKYSEVVLDSEPKPQASGPEPELYASVCAQTRRARASFPDQAYANSQPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZ90</accession>
    <name>A0A8C5XZ90_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transforming acidic coiled-coil containing protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TACC3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TACC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021821">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021822">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021823">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZ90"/>
    <dbReference type="Ensembl" id="ENSMICT00000062316.1">
        <property type="protein sequence ID" value="ENSMICP00000043810.1"/>
        <property type="gene ID" value="ENSMICG00000038424.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158858"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1700:FF:000001">
        <property type="entry name" value="Transforming acidic coiled-coil-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039915">
        <property type="entry name" value="TACC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057663">
        <property type="entry name" value="TACC3_Aurora-A_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007707">
        <property type="entry name" value="TACC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL CONTAINING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13924:SF4">
        <property type="entry name" value="TRANSFORMING ACIDIC COILED-COIL-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25777">
        <property type="entry name" value="Aurora-A_bind_TACC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05010">
        <property type="entry name" value="TACC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transforming acidic coiled-coil-containing protein C-terminal" evidence="9">
        <location>
            <begin position="479"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="488"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="601"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="677" mass="74366" checksum="03181AD8FDB0AA13" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZR5</accession>
    <name>A0A8C5XZR5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEC16A</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">SEC16A and SEC16B are each present in multiple copies in a heteromeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015014">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068674.1">
        <property type="protein sequence ID" value="ENSMICP00000043971.1"/>
        <property type="gene ID" value="ENSMICG00000005865.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159324"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
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    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
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    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein transport protein sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
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    <dbReference type="PANTHER" id="PTHR13402:SF13">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="14 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0492">Microsome</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="1440"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="18">
        <location>
            <begin position="1610"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="region of interest" description="Disordered" evidence="17">
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    <feature type="compositionally biased region" description="Polar residues" evidence="17">
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            <dbReference type="ARBA" id="ARBA00022848"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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            <dbReference type="ARBA" id="ARBA00023034"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF12931"/>
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        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
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    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043971.1"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
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    <sequence length="2326" mass="250238" checksum="FBC2109B124C6127" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y0R2</accession>
    <name>A0A8C5Y0R2_MICMU</name>
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        <recommendedName>
            <fullName evidence="11">RILP-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RILPL2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines. Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024804">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y0R2"/>
    <dbReference type="Ensembl" id="ENSMICT00000062349.1">
        <property type="protein sequence ID" value="ENSMICP00000044142.1"/>
        <property type="gene ID" value="ENSMICG00000047555.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160182"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003382">
        <property type="term" value="P:epithelial cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903445">
        <property type="term" value="P:protein transport from ciliary membrane to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14445">
        <property type="entry name" value="RILP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1770:FF:000003">
        <property type="entry name" value="RILP-like protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034743">
        <property type="entry name" value="RH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034744">
        <property type="entry name" value="RH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021563">
        <property type="entry name" value="RILP_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF2">
        <property type="entry name" value="RILP-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09744">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11461">
        <property type="entry name" value="RILP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161256">
        <property type="entry name" value="RILP dimerisation region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51776">
        <property type="entry name" value="RH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51777">
        <property type="entry name" value="RH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RH1" evidence="14">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="RH2" evidence="15">
        <location>
            <begin position="131"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="211" mass="24016" checksum="8CB6CD616FD5A896" modified="2022-01-19" version="1">MEEPPLREEEEEEEEDDDEERDEAGPEGALGKSPSRLTAEDVYDISFVVGRELMALGSDPRVTQLQFKIVRVLEMLEALVSEGNLTAEALRMERDSLRKEVEGLRREGPPASREANLGPDKMVVDLTDPNRPRFTLQELRDVLQERNRLKSQLLVAQEELQCYKSGLFPPREVPGGREEKDVLVSRASSAGRNKEEKTIIKKLVCCFREQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y2U5</accession>
    <name>A0A8C5Y2U5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Parafibromin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division cycle protein 73 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CDC73</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and SKIC8. The PAF1 complex interacts with PHF5A. Within the PAF1 complex interacts directly with PHF5A. Interacts with POLR2A, CPSF1, CPSF4, CSTF2, KMT2A/MLL1 and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex. Interacts with PTPN11. Interacts with SETD5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627866.1">
        <property type="nucleotide sequence ID" value="XM_012772412.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y2U5"/>
    <dbReference type="Ensembl" id="ENSMICT00000067391.1">
        <property type="protein sequence ID" value="ENSMICP00000044438.1"/>
        <property type="gene ID" value="ENSMICG00000010319.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875399"/>
    <dbReference type="KEGG" id="mmur:105875399"/>
    <dbReference type="CTD" id="79577"/>
    <dbReference type="GeneTree" id="ENSGT00390000001114"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000001">
        <property type="entry name" value="Cell division cycle 73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032041">
        <property type="entry name" value="Cdc73_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16050">
        <property type="entry name" value="CDC73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Paf1 complex subunit Cdc73 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="10">
        <location>
            <begin position="357"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="531" mass="60607" checksum="894A73396BC0EBE2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4V2</accession>
    <name>A0A8C5Y4V2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arrestin domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ARRDC2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027650">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4V2"/>
    <dbReference type="Ensembl" id="ENSMICT00000059607.1">
        <property type="protein sequence ID" value="ENSMICP00000045220.1"/>
        <property type="gene ID" value="ENSMICG00000048039.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159994"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000007">
        <property type="entry name" value="Arrestin domain-containing protein 3 mRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF48">
        <property type="entry name" value="ARRESTIN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="180"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="461" mass="49414" checksum="A07194BB47B27DAD" modified="2022-01-19" version="1">MLFDKVKAFAVRLDGASAGAEPVFSGGQAVVGRVLLELAGPARVGALKLRARGRARVHWTESRSAGSSTAYTQSYSERVEVVSHRATLLAPDTGEATTLPPGRHEFPFSFQLPPTLVTSFEGKHGSVRYCIKATLHRPWVPARRAKKVFTVIEPVDINTPALLAPQAGAREKEARSWYYNQGLVSLSAKIERKGYTPGEAIPIFAEIDNGSRRPVLPRAALVQTQTFLARGARKQKRAVVASLAGEPVAPGRRALWRGRALRIPPVGPSILRCRVLHVDYALKVCVDIPGASKLLLELPLVIGTVPCILSDSPIVPRGQPPSGQRPPTQKGAAESTWVARSTRDSGEGTGLAAAEPALVPGPQGTLCALTPRLSISAPPEYSEVVAEEEMVASGQSPSLSLQDPDVSLDGPFFAFIQEFRYRPPPLYSEVSSRLWGPCDKCETHTGGGVRFGDGVSLYCPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7B0</accession>
    <name>A0A8C5Y7B0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003663">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7B0"/>
    <dbReference type="Ensembl" id="ENSMICT00000068874.1">
        <property type="protein sequence ID" value="ENSMICP00000046557.1"/>
        <property type="gene ID" value="ENSMICG00000046706.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183013"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000556">
        <property type="entry name" value="Immunoglobulin heavy variable 7-81 (non-functional)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="101" mass="11237" checksum="34D6C9C0EE1B5BCD" modified="2022-01-19" version="1">EVQLVQSGAQVKPPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMRLINPNNGGTNYAQKFQGRVTMTRDTSTSTAYMELSSLRPEDTAVYYCARDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7V7</accession>
    <name>A0A8C5Y7V7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein eL33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60S ribosomal protein L35a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105885967</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for the proliferation and viability of hematopoietic cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7V7"/>
    <dbReference type="Ensembl" id="ENSMICT00000063283.1">
        <property type="protein sequence ID" value="ENSMICP00000046408.1"/>
        <property type="gene ID" value="ENSMICG00000041516.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016972"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000005">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="110" mass="12526" checksum="52CE48CD41546F24" modified="2022-01-19" version="1">MSGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYSRDETEFYLGKRCAYVYKAKNNTVTPGGKPNKTRVIWGKVTQAHGNSGMVRAKFRSNLPAKAIGHRIRVMLYPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8F1</accession>
    <name>A0A8C5Y8F1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105864137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016882">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y8F1"/>
    <dbReference type="Ensembl" id="ENSMICT00000060258.1">
        <property type="protein sequence ID" value="ENSMICP00000046648.1"/>
        <property type="gene ID" value="ENSMICG00000046930.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182922"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="160" mass="18512" checksum="841D0B5E9312BB35" modified="2022-01-19" version="1">MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKCVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8I8</accession>
    <name>A0A8C5Y8I8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable RNA polymerase II nuclear localization protein SLC7A6OS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC7A6OS</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Directs RNA polymerase II nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597818.1">
        <property type="nucleotide sequence ID" value="XM_012742364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y8I8"/>
    <dbReference type="Ensembl" id="ENSMICT00000066153.1">
        <property type="protein sequence ID" value="ENSMICP00000047557.1"/>
        <property type="gene ID" value="ENSMICG00000041758.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105858930"/>
    <dbReference type="CTD" id="84138"/>
    <dbReference type="GeneTree" id="ENSGT00390000015672"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040218">
        <property type="entry name" value="SLC7A6OS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31196:SF2">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN SLC7A6OS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="11">
        <location>
            <begin position="194"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="309" mass="35019" checksum="83FE622C24483966" modified="2022-01-19" version="1">MEAGRTAVLRVKRKRSAEPAEALVLACKRLRSGVVDSIAQKAPEGLERAAENNVFQLVATVCSQEEPIQPLLRAALHPSRGSQQRIRSDLRASAREIRREGRYRVVSSRRSLGSTSSCLESECAAENPEAAKDSGFQLFDLIHEEGEPETASADPCKTSDPDVILCNSVKLIRERLTISEDGPGVRHQEEQKHDNYVYDIYYLDMATSGWIENILSVQPYSQEWELVNDDQEPEDVYDDEDDENSENNWRNEYPEEESSDGDEASRGSDEYNSLSEEEKGSSRHQMWNKYPLDVQKEFGYENPHDLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y9T1</accession>
    <name>A0A8C5Y9T1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PR domain-containing protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PRDM11</name>
        <name evidence="17" type="synonym">LOC105885401</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May be involved in transcription regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y9T1"/>
    <dbReference type="Ensembl" id="ENSMICT00000061249.1">
        <property type="protein sequence ID" value="ENSMICP00000048223.1"/>
        <property type="gene ID" value="ENSMICG00000014133.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159837"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19195">
        <property type="entry name" value="PR-SET_PRDM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000014">
        <property type="entry name" value="PR domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044405">
        <property type="entry name" value="PRDM11_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057456">
        <property type="entry name" value="Znf_C17orf113"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880:SF11">
        <property type="entry name" value="PR_SET DOMAIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46880">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25431">
        <property type="entry name" value="zf-C17orf113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="115"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="353"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="465"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1177" mass="134033" checksum="9E47307934E4E5C8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YBJ6</accession>
    <name>A0A8C5YBJ6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TNFR-Cys domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03002115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YBJ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000065453.1">
        <property type="protein sequence ID" value="ENSMICP00000048609.1"/>
        <property type="gene ID" value="ENSMICG00000047725.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162427"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046642">
        <property type="term" value="P:negative regulation of alpha-beta T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002720">
        <property type="term" value="P:positive regulation of cytokine production involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000406">
        <property type="term" value="P:positive regulation of T cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10582">
        <property type="entry name" value="TNFRSF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000007">
        <property type="entry name" value="TNF receptor superfamily member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022332">
        <property type="entry name" value="TNFR_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034031">
        <property type="entry name" value="TNFRSF14/UL144_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46838">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46838:SF1">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01965">
        <property type="entry name" value="TNFACTORR14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034311208" description="TNFR-Cys domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="37"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="4">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="266" mass="28046" checksum="CF632066ECC994E7" modified="2022-01-19" version="1">MGNMGPPPWAPKAHAFPLVLYLLFLESPRCAPALPSCKEEEYPVGTECCPKCSPGYHVKQACGELTGTVCVPCPPRTYTAHHNGLSECLPCRVCDPGTRATPPAPPPARLHGDGDHCAACASHSSCRPGQEVQERGELAGGLPPLTPAPSSLVARASDQAPLHFSGTKAGNTTPGTSSSDATCSLKTSLLGVISVVALVSMLGPVTFYLWRRTKARGERVRPLLSDWGREVQDTEGEATDLQAPPDVTTVAVEETSPKFPGRDPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YDM4</accession>
    <name>A0A8C5YDM4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTPase IMAP family member GIMD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GIMAP family P-loop NTPase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GIMD1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YDM4"/>
    <dbReference type="Ensembl" id="ENSMICT00000067245.1">
        <property type="protein sequence ID" value="ENSMICP00000049176.1"/>
        <property type="gene ID" value="ENSMICG00000045116.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000069080"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001392">
        <property type="entry name" value="GTPase IMAP family member GIMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF103">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER GIMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIG1-type G" evidence="6">
        <location>
            <begin position="29"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="240" mass="27059" checksum="C4756A455A54AB77" modified="2022-01-19" version="1">TKEQLYQLKARLCGESIFKTGKAMADPTKMVVNLALFGTTQSGKSSAGNTLLGSADFHSSFAPCSVTQDCSLGRSCHLQSFLRRRGQEVALQVRVLDTPGCPHSRLSKKDVEQKVRDALEHHFGQEGLHLALLVQRADVPFCGQEATYPVQMIQELLGHAWKNYTAILFTHAEKIEEAGSNEDKYLRAAPDTLLTLLNSIQHKYVFQHKKEKSFNEQRMKILERIMGFVKENCYQVLTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEU3</accession>
    <name>A0A8C5YEU3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024738">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000047293.1"/>
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        <property type="component" value="Chromosome 21"/>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Immunoglobulin lambda variable 6-57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
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        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="108" mass="11577" checksum="52DD5A9912A38953" modified="2022-01-19" version="1">NLVLTQPSSVSGSPGQKVTISCTRSSGSIGDYYVHWYQQRPGSAPTTVIYGDDKRPSGVPDRFSGSIDSSSNSASLTISGLQSEDEADYYCQSYDDSNNHTVLQSMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFI5</accession>
    <name>A0A8C5YFI5_MICMU</name>
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        <submittedName>
            <fullName evidence="5">SRA stem-loop interacting RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SLIRP</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003916">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFI5"/>
    <dbReference type="Ensembl" id="ENSMICT00000064389.1">
        <property type="protein sequence ID" value="ENSMICP00000050038.1"/>
        <property type="gene ID" value="ENSMICG00000012080.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008624"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097222">
        <property type="term" value="P:mitochondrial mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905638">
        <property type="term" value="P:negative regulation of mitochondrial mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12242">
        <property type="entry name" value="RRM_SLIRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034152">
        <property type="entry name" value="SLIRP_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF61">
        <property type="entry name" value="SRA STEM-LOOP INTERACTING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="117" mass="13449" checksum="3CB12EA6523AF626" modified="2022-01-19" version="1">MAALAARSVVSLRRSVNRPVAFVRKIPWTAASSEMREHFAQFGHIRRCFLPFDKETGFHKGFGWVQFSTEEELQNALQQENHFIDGVKESSFRETEPPQVNRRKAAQSHPARSTPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFL9</accession>
    <name>A0A8C5YFL9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">CD320 molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CD320</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645818.2">
        <property type="nucleotide sequence ID" value="XM_012790364.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFL9"/>
    <dbReference type="Ensembl" id="ENSMICT00000065385.1">
        <property type="protein sequence ID" value="ENSMICP00000050253.1"/>
        <property type="gene ID" value="ENSMICG00000046176.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885456"/>
    <dbReference type="CTD" id="51293"/>
    <dbReference type="GeneTree" id="ENSGT00730000111436"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031296">
        <property type="term" value="P:B cell costimulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015889">
        <property type="term" value="P:cobalamin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000045">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050685">
        <property type="entry name" value="LDLR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270:SF27">
        <property type="entry name" value="CD320 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24270">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150558" evidence="13">
        <location>
            <begin position="26"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="252" mass="26541" checksum="ABE3D52E1F50A8B7" modified="2022-01-19" version="1">MALGGAPGTAALGLALRLLLGLAVALEAAPTRFPTRTSAQAAGSCPPANFQCHTNGFCVPLTWRCDGDWDCSDGSDEEECRIEPCAQSRHCPPPAGRPCSCDGIGNCTDEELRNCSRPACPAGEQPCAQGDTCIPRTWHCDGHPDCPDLSDELGCGPKETFQEGNATTTWTPVTPESVTSLGNATVYSIWDQFGNPSTYGVIIAAMMLIMTLVTAALLVLCWLQAQGRLPPPGLLVAVKESLLPLGRKTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EDH0</accession>
    <name>A0A8C6EDH0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alkylglycerone-phosphate synthase</fullName>
            <shortName evidence="5">Alkyl-DHAP synthase</shortName>
            <ecNumber evidence="2 5">2.5.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">AGPS</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long chain fatty alcohol + a 1-acylglycerone 3-phosphate = a 1-O-alkylglycerone 3-phosphate + a long-chain fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36171"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57534"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:73315"/>
            <dbReference type="EC" id="2.5.1.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Glycerolipid metabolism; ether lipid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.26" evidence="2 5"/>
    <dbReference type="EMBL" id="ABDC03011060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EDH0"/>
    <dbReference type="Ensembl" id="ENSMICT00000049249.2">
        <property type="protein sequence ID" value="ENSMICP00000039166.1"/>
        <property type="gene ID" value="ENSMICG00000003750.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156112"/>
    <dbReference type="UniPathway" id="UPA00781"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008609">
        <property type="term" value="F:alkylglycerone-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008611">
        <property type="term" value="P:ether lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000002">
        <property type="entry name" value="Alkylglycerone-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025650">
        <property type="entry name" value="Alkyl-DHAP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46568:SF1">
        <property type="entry name" value="ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD-binding oxidoreductase/transferase type 4 C-terminal" evidence="7">
        <location>
            <begin position="126"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="186" mass="19910" checksum="17D69AC9EA65F49A" modified="2022-01-19" version="1">MAEAAAAAAGGTGAGSGSVADRDRDRDPDRAGRRLRVLSGHLLGRPQEALSTNECKARRAASAATAAPTATPAAQESGTIPKKRQEVMKWNGWGYNDSKFLFNKKGQIELTGKRGISDPLAVFEQTEAAAREEILANGGSLSHHHGVGKLRKQWLKESISDVGFGMLKSVKEYVDPNNIFGNRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKS6</accession>
    <name>A0A8C6EKS6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">H2AC25</name>
        <name evidence="20" type="synonym">LOC105878818</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017959">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634027.1">
        <property type="nucleotide sequence ID" value="XM_012778573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKS6"/>
    <dbReference type="SMR" id="A0A8C6EKS6"/>
    <dbReference type="Ensembl" id="ENSMICT00000064279.1">
        <property type="protein sequence ID" value="ENSMICP00000049072.1"/>
        <property type="gene ID" value="ENSMICG00000044054.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878818"/>
    <dbReference type="KEGG" id="mmur:105878818"/>
    <dbReference type="GeneTree" id="ENSGT00940000153092"/>
    <dbReference type="OMA" id="WRRHEGR"/>
    <dbReference type="OrthoDB" id="9538401at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0164">Citrullination</keyword>
    <keyword evidence="12 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="14 16" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="19">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="130" mass="14121" checksum="ECFC34D4B2CC89F0" modified="2022-01-19" version="1">MSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>D1GFC3</accession>
    <name>D1GFC3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TYRO protein tyrosine kinase-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNAX-activation protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18 21" type="primary">DAP12</name>
        <name evidence="19 21" type="synonym">TYROBP</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="e1000688" last="e1000688">
            <title>A novel system of polymorphic and diverse NK cell receptors in primates.</title>
            <authorList>
                <person name="Averdam A."/>
                <person name="Petersen B."/>
                <person name="Rosner C."/>
                <person name="Neff J."/>
                <person name="Roos C."/>
                <person name="Eberle M."/>
                <person name="Aujard F."/>
                <person name="Munch C."/>
                <person name="Schempp W."/>
                <person name="Carrington M."/>
                <person name="Shiina T."/>
                <person name="Inoko H."/>
                <person name="Knaust F."/>
                <person name="Coggill P."/>
                <person name="Sehra H."/>
                <person name="Beck S."/>
                <person name="Abi-Rached L."/>
                <person name="Reinhardt R."/>
                <person name="Walter L."/>
            </authorList>
            <dbReference type="PubMed" id="19834558"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000688"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <tissue evidence="18">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2022-04" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="5">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TYROBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FJ882074">
        <property type="protein sequence ID" value="ACY91939.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="EMBL" id="FJ882076">
        <property type="protein sequence ID" value="ACY91941.1"/>
        <property type="molecule type" value="mRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630436.1">
        <property type="nucleotide sequence ID" value="XM_012774982.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="D1GFC3"/>
    <dbReference type="Ensembl" id="ENSMICT00000070378.1">
        <property type="protein sequence ID" value="ENSMICP00000048651.1"/>
        <property type="gene ID" value="ENSMICG00000032551.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876902"/>
    <dbReference type="CTD" id="7305"/>
    <dbReference type="GeneTree" id="ENSGT00390000016786"/>
    <dbReference type="OrthoDB" id="9901873at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMICG00000032551">
        <property type="expression patterns" value="Expressed in lung and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097242">
        <property type="term" value="P:amyloid-beta clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043277">
        <property type="term" value="P:apoptotic cell clearance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904646">
        <property type="term" value="P:cellular response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030900">
        <property type="term" value="P:forebrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002282">
        <property type="term" value="P:microglial cell activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002228">
        <property type="term" value="P:natural killer cell mediated immunity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030889">
        <property type="term" value="P:negative regulation of B cell proliferation"/>
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    <dbReference type="GO" id="GO:0032693">
        <property type="term" value="P:negative regulation of interleukin-10 production"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1900272">
        <property type="term" value="P:negative regulation of long-term synaptic potentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032911">
        <property type="term" value="P:negative regulation of transforming growth factor beta1 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002283">
        <property type="term" value="P:neutrophil activation involved in immune response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:osteoclast differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032731">
        <property type="term" value="P:positive regulation of interleukin-1 beta production"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of macrophage fusion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of microglial cell mediated cytotoxicity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of natural killer cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001206">
        <property type="term" value="P:positive regulation of osteoclast development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1902685">
        <property type="term" value="P:positive regulation of receptor localization to synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032930">
        <property type="term" value="P:positive regulation of superoxide anion generation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002223">
        <property type="term" value="P:stimulatory C-type lectin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002222">
        <property type="term" value="P:stimulatory killer cell immunoglobulin-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002291">
        <property type="term" value="P:T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000004">
        <property type="entry name" value="TYRO protein tyrosine kinase-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026200">
        <property type="entry name" value="Tyrobp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17554">
        <property type="entry name" value="TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17554:SF2">
        <property type="entry name" value="TYRO PROTEIN TYROSINE KINASE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="21" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="21" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007650183" description="TYRO protein tyrosine kinase-binding protein" evidence="17">
        <location>
            <begin position="28"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00031252"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACY91939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048651.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_012630436.1"/>
        </source>
    </evidence>
    <sequence length="112" mass="12043" checksum="4BD45662BFAFD74E" modified="2010-01-19" version="1">MGGLEPSGRLLLLPLLLTVGGLSPVQAQSECNCASVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVPRGRGRGAVEVTRKQRMTETESPYQELQGQRADVYSDLNTQRQYYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ECP6</accession>
    <name>A0A8B7ECP6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine transcarbamylase, mitochondrial</fullName>
            <ecNumber evidence="5">2.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Ornithine carbamoyltransferase, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">OTC</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline. The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:19515"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nitrogen metabolism; urea cycle; L-citrulline from L-ornithine and carbamoyl phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03036425">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592134.1">
        <property type="nucleotide sequence ID" value="XM_012736680.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ECP6"/>
    <dbReference type="Ensembl" id="ENSMICT00000011722.3">
        <property type="protein sequence ID" value="ENSMICP00000010670.2"/>
        <property type="gene ID" value="ENSMICG00000011724.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855609"/>
    <dbReference type="KEGG" id="mmur:105855609"/>
    <dbReference type="CTD" id="5009"/>
    <dbReference type="GeneTree" id="ENSGT00510000047417"/>
    <dbReference type="OrthoDB" id="10252326at2759"/>
    <dbReference type="UniPathway" id="UPA00158">
        <property type="reaction ID" value="UER00271"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006593">
        <property type="term" value="P:L-ornithine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000009">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000010">
        <property type="entry name" value="Ornithine carbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001986">
        <property type="entry name" value="PRK00779.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753">
        <property type="entry name" value="ORNITHINE CARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45753:SF3">
        <property type="entry name" value="ORNITHINE TRANSCARBAMYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0835">Urea cycle</keyword>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase carbamoyl-P binding" evidence="18">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartate/ornithine carbamoyltransferase Asp/Orn-binding" evidence="17">
        <location>
            <begin position="187"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010670.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="354" mass="39950" checksum="F2F6A350F30092B7" modified="2022-01-19" version="1">MLFNLRILLNNAALRNGHNFVVRHFRCGQPLQNKVQLKGRDLLTLKNFTGEEIKYMLWLSADLKFRIKQKGEYLPLLQGKSLGMIFEKRSTRTRLSTETGFALLGGHPCFLTTQDIHLGVNESLTDTARVLSSMTDAVLARVYKQSDLDILAKEASIPIVNGLSDLYHPIQILADYLTLQEHYGSLKGLTLSWIGDGNNILHSIMMSAAKFGMHLQAATPKGYEPDPNITKLAEQYAKENGTKLSLTNDPLEAARGGNVLITDTWISMGQEEEKKKRLQAFQGYQVTMKTAKVAASDWTFLHCLPRKPEEVDDEVFYSPRSLVFPEAENRKWTIMAVMVSLLTDYSPQLQKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDN2</accession>
    <name>A0A8B7EDN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cis-aconitate decarboxylase</fullName>
            <ecNumber evidence="12">4.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Aconitate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Aconitate decarboxylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cis-aconitic acid decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Immune-responsive gene 1 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ACOD1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB. Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes. Plays a role in the embryo implantation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>cis-aconitate + H(+) = itaconate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15253"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16383"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17240"/>
            <dbReference type="EC" id="4.1.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15254"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.6" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03017458">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592524.1">
        <property type="nucleotide sequence ID" value="XM_012737070.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EDN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000050675.2">
        <property type="protein sequence ID" value="ENSMICP00000034593.1"/>
        <property type="gene ID" value="ENSMICG00000027082.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105855853"/>
    <dbReference type="KEGG" id="mmur:105855853"/>
    <dbReference type="CTD" id="730249"/>
    <dbReference type="GeneTree" id="ENSGT00390000015700"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047613">
        <property type="term" value="F:aconitate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002760">
        <property type="term" value="P:positive regulation of antimicrobial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072573">
        <property type="term" value="P:tolerance induction to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000002">
        <property type="entry name" value="Aconitate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000002">
        <property type="entry name" value="Aconitate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF11">
        <property type="entry name" value="CIS-ACONITATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="19">
        <location>
            <begin position="273"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="472" mass="51634" checksum="90B1FAD808A45E89" modified="2022-01-19" version="1">MLKSVTESFAKVIHGLKVGHLTDQVIQRSKRMILDTLGVGFLGTSTDVFHKASQYSKIYSSNISSTVWGQPDFRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALSEALPQSPKFSGLDLLLAFNVGIEVQGRLMHFSKEAKDIPKRFHPPSVVGTLGSAAAASKFLGLSLTKCQEALAIAVSYAGAPMANAATETKPLHIGNAAKHGIEAAFLAMLGLQGNKQALDLEAGFGAFYANYSPKVLPNLDSHTWLLDQQDVAIKSFPAHLATHWVADAAASVRKHLVTETALFPTEHIKRVVLRIPKVQYVNRPFPDSEHEARHSFQYVACAMLLDGDITVSSFQKHQINRPQVRELLSKVELEHPPDNLPSFNTLYCEISVTLKDGTTFTHRSDTFYGHWRKPLNQKDLEAKFRANASTTLSCDTVESLIKIVEKLEDLEDCSVLTTLLKGSSTPEAASKLSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EFP7</accession>
    <name>A0A8B7EFP7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Arf-GAP with dual PH domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Centaurin-alpha-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ADAP2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03019934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593332.1">
        <property type="nucleotide sequence ID" value="XM_012737878.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EFP7"/>
    <dbReference type="Ensembl" id="ENSMICT00000048703.2">
        <property type="protein sequence ID" value="ENSMICP00000021313.1"/>
        <property type="gene ID" value="ENSMICG00000003621.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856285"/>
    <dbReference type="KEGG" id="mmur:105856285"/>
    <dbReference type="CTD" id="55803"/>
    <dbReference type="GeneTree" id="ENSGT00940000156498"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043533">
        <property type="term" value="F:inositol 1,3,4,5 tetrakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08844">
        <property type="entry name" value="ArfGap_ADAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000015">
        <property type="entry name" value="arf-GAP with dual PH domain-containing protein 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF6">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="15">
        <location>
            <begin position="9"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="255"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="381" mass="44181" checksum="733FF759D7D58563" modified="2022-01-19" version="1">MGDSERNKKRLLELLRAAGTGNALCADCGAPDPDWASYKLGIFICLNCSGVHRNFPDISKVKSVRLDFWDDSIVEFMIHNGNLRVKAKFEARVPAFYYIPQASDCLVLKEQWIRAKYERQEFMADGKTISPPGNREGFLWKRGRDNAQFLRRRFVLLAREGLLKYYTKEEGKTPKAVISIKDLNATFQTEKIGHPHGLQITYRKEGHTRNLFVYHENGKEIVDWFNALRAARLQYLKMAFPELPESELLPLLTRNYLKQGFMEKTGPKQREPFKKRWFALDSQERRLLYYKNPLDAFEQGQVFLGSNEQGYEIYEDLPKGIRGNRWKAGITIVTPERRFVLTCPSEKEQREWLESLRDVLSRPLTPLNLITASTESGCSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ETN9</accession>
    <name>A0A8B7ETN9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C-C motif chemokine</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CCL2</name>
        <name evidence="11" type="synonym">LOC105859340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the intercrine beta (chemokine CC) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ETN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000036389.2">
        <property type="protein sequence ID" value="ENSMICP00000030081.1"/>
        <property type="gene ID" value="ENSMICG00000034682.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105859340"/>
    <dbReference type="GeneTree" id="ENSGT01130000278316"/>
    <dbReference type="OrthoDB" id="9930747at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043615">
        <property type="term" value="P:astrocyte cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044344">
        <property type="term" value="P:cellular response to fibroblast growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
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        <property type="term" value="P:negative regulation of glial cell apoptotic process"/>
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        <property type="term" value="P:negative regulation of natural killer cell chemotaxis"/>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Chemokine_CC"/>
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        <property type="entry name" value="Chemokine_IL8-like_dom"/>
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        <property type="entry name" value="Interleukin_8-like_sf"/>
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        <property type="entry name" value="C-C MOTIF CHEMOKINE 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00472">
        <property type="entry name" value="SMALL_CYTOKINES_CC"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3 8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5044038118" description="C-C motif chemokine" evidence="8">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="9">
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    <sequence length="119" mass="12909" checksum="90630E75BC4A992A" modified="2022-01-19" version="1">MKVSAALLCLLLVAAAFSPQGLAQPDAVNAPVTCCYTFSSRKISLQRLTSYRRVSNSKCPKEAVIFKTILAKEICANPEQNWVKDYIAKLDKKTQTPTPSNTPSTTQESTTNLSSPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EVW2</accession>
    <name>A0A8B7EVW2_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Alpha-N-acetylglucosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NAGLU</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides.</text>
            <dbReference type="EC" id="3.2.1.50"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 89 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012743201.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000046589.1"/>
        <property type="gene ID" value="ENSMICG00000047584.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105859410"/>
    <dbReference type="KEGG" id="mmur:105859410"/>
    <dbReference type="CTD" id="4669"/>
    <dbReference type="GeneTree" id="ENSGT00390000005900"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
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        <property type="component" value="Chromosome 16"/>
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    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:membrane"/>
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        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0004561">
        <property type="term" value="F:alpha-N-acetylglucosaminidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0140315">
        <property type="term" value="F:iron ion sequestering activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:adult behavior"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042982">
        <property type="term" value="P:amyloid precursor protein metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:aorta morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:astrocyte activation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0055013">
        <property type="term" value="P:cardiac muscle cell development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097696">
        <property type="term" value="P:cell surface receptor signaling pathway via STAT"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0021680">
        <property type="term" value="P:cerebellar Purkinje cell layer development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:collagen metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cone retinal bipolar cell differentiation"/>
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        <property type="term" value="P:determination of adult lifespan"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:endothelium development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030203">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:hair follicle morphogenesis"/>
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    <dbReference type="GO" id="GO:0030200">
        <property type="term" value="P:heparan sulfate proteoglycan catabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:inner ear receptor cell development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003220">
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    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045475">
        <property type="term" value="P:locomotor rhythm"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035633">
        <property type="term" value="P:maintenance of blood-brain barrier"/>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
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                <person name="Blankenburg K."/>
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                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
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                <person name="Kurapati P."/>
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                <person name="Lee S."/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039525.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="256" mass="27287" checksum="B6D729282EBCBE07" modified="2022-01-19" version="1">MVTSVLLALLLGGPALASEIVGGRPARPHAWPFMVSLQQRGGHFCGATLIAPSFVMSAAHCVNGRNFRSVQVVLGAHDLRLREPTRQMFGVRRVFENGFDPQNLRNDIVILQLNGSATINANVQAARLPAQDRGVGNGTRCLAMGWGQLGNNRPPPSVLQELNVTVVTALCNNRRNVCTLAGRRRAGICFGDSGGPLVCSGVVQGIDSFVRGGCGSGFYPDGFAPVAQFADWINSIIQRPGGHPLPHPRDPASRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2B3</accession>
    <name>A0A8B7F2B3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">GCSH</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="function">
        <text evidence="6">The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="8">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602021.1">
        <property type="nucleotide sequence ID" value="XM_012746567.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F2B3"/>
    <dbReference type="Ensembl" id="ENSMICT00000061517.1">
        <property type="protein sequence ID" value="ENSMICP00000043421.1"/>
        <property type="gene ID" value="ENSMICG00000045290.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105861205"/>
    <dbReference type="KEGG" id="mmur:105861205"/>
    <dbReference type="CTD" id="2653"/>
    <dbReference type="GeneTree" id="ENSGT00390000011666"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000045">
        <property type="entry name" value="Glycine cleavage system H protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF42">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="173" mass="18796" checksum="6AB77932B3B04252" modified="2022-01-19" version="1">MALRAARSVRPVLCSLRSASATATPCPPRPWRLAAGAVRTLRTGPALLSVRKFTEKHEWVTTENGVGTVGISNFAQESLGDVVYCSLPEVGTKLNKQEEFGALESVKAASELYSPLSGEVTEINGALTENPGLVNKSCYEDGWLIKMTLSNPSELDELMSEEAYEKYVKSIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FFD9</accession>
    <name>A0A8B7FFD9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Striatin-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein FAM40A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STRIP1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26. The STRIPAK complex can be extended by adapter proteins such as SLMAP:SIKE1, CTTNBP2 or CTTNBP2NL. Interacts with CDC42BPB. Interacts with CTTNBP2NL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STRIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002909">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607042.1">
        <property type="nucleotide sequence ID" value="XM_012751588.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FFD9"/>
    <dbReference type="Ensembl" id="ENSMICT00000039603.2">
        <property type="protein sequence ID" value="ENSMICP00000021742.1"/>
        <property type="gene ID" value="ENSMICG00000005215.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863990"/>
    <dbReference type="KEGG" id="mmur:105863990"/>
    <dbReference type="CTD" id="85369"/>
    <dbReference type="GeneTree" id="ENSGT00400000022095"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF7">
        <property type="entry name" value="STRIATIN-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="10">
        <location>
            <begin position="65"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="11">
        <location>
            <begin position="460"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="837" mass="95678" checksum="ABAE218B59F86667" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FFP2</accession>
    <name>A0A8B7FFP2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Voltage-gated potassium channel KCNC4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Potassium voltage-gated channel subfamily C member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Voltage-gated potassium channel subunit Kv3.4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">KCNC4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Voltage-gated potassium channel that opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotetramer. Heterotetramer of potassium channel proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002909">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607154.1">
        <property type="nucleotide sequence ID" value="XM_012751700.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FFP2"/>
    <dbReference type="Ensembl" id="ENSMICT00000053049.2">
        <property type="protein sequence ID" value="ENSMICP00000023920.1"/>
        <property type="gene ID" value="ENSMICG00000005247.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864051"/>
    <dbReference type="KEGG" id="mmur:105864051"/>
    <dbReference type="CTD" id="3749"/>
    <dbReference type="GeneTree" id="ENSGT00940000158860"/>
    <dbReference type="OrthoDB" id="10025005at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032590">
        <property type="term" value="C:dendrite membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032809">
        <property type="term" value="C:neuronal cell body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005251">
        <property type="term" value="F:delayed rectifier potassium channel activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18415">
        <property type="entry name" value="BTB_KCNC2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
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    </dbReference>
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        <property type="entry name" value="Potassium channel, voltage-gated Shaw-related subfamily C, member 4"/>
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    </dbReference>
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        <property type="entry name" value="potassium voltage-gated channel subfamily C member 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003968">
        <property type="entry name" value="K_chnl_volt-dep_Kv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003974">
        <property type="entry name" value="K_chnl_volt-dep_Kv3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005405">
        <property type="entry name" value="K_chnl_volt-dep_Kv3.4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021645">
        <property type="entry name" value="Shal-type_N"/>
    </dbReference>
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        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF126">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11601">
        <property type="entry name" value="Shal-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01583">
        <property type="entry name" value="KV34CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01491">
        <property type="entry name" value="KVCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01498">
        <property type="entry name" value="SHAWCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="313"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
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            <begin position="381"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
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            <begin position="423"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="452"/>
            <end position="481"/>
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    </feature>
    <feature type="domain" description="BTB" evidence="25">
        <location>
            <begin position="36"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="66"/>
            <end position="85"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="490"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00062770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="626" mass="68708" checksum="9FACBC648350B675" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FJB7</accession>
    <name>A0A8B7FJB7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dermatan sulfate epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DSE</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dermatan-sulfate isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608677.1">
        <property type="nucleotide sequence ID" value="XM_012753223.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FJB7"/>
    <dbReference type="Ensembl" id="ENSMICT00000008107.3">
        <property type="protein sequence ID" value="ENSMICP00000007387.1"/>
        <property type="gene ID" value="ENSMICG00000008111.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864972"/>
    <dbReference type="KEGG" id="mmur:105864972"/>
    <dbReference type="CTD" id="29940"/>
    <dbReference type="GeneTree" id="ENSGT00390000006522"/>
    <dbReference type="OMA" id="FFIHAVC"/>
    <dbReference type="OrthoDB" id="5946629at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047757">
        <property type="term" value="F:chondroitin-glucuronate 5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050651">
        <property type="term" value="P:dermatan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.100:FF:000001">
        <property type="entry name" value="dermatan-sulfate epimerase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.70:FF:000001">
        <property type="entry name" value="dermatan-sulfate epimerase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052447">
        <property type="entry name" value="Dermatan-Sulfate_Isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15532">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15532:SF3">
        <property type="entry name" value="DERMATAN-SULFATE EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133601" evidence="10">
        <location>
            <begin position="23"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="902"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="933"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="957" mass="109652" checksum="946951E50CBCB63E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FP12</accession>
    <name>A0A8B7FP12_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBC1 domain family member 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TBC1D20</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610593.1">
        <property type="nucleotide sequence ID" value="XM_012755139.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FP12"/>
    <dbReference type="Ensembl" id="ENSMICT00000060102.1">
        <property type="protein sequence ID" value="ENSMICP00000045519.1"/>
        <property type="gene ID" value="ENSMICG00000043422.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866007"/>
    <dbReference type="KEGG" id="mmur:105866007"/>
    <dbReference type="CTD" id="128637"/>
    <dbReference type="GeneTree" id="ENSGT00390000014944"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044829">
        <property type="term" value="P:host-mediated activation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070309">
        <property type="term" value="P:lens fiber cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034389">
        <property type="term" value="P:lipid droplet organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046726">
        <property type="term" value="P:positive regulation by virus of viral protein levels in host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902953">
        <property type="term" value="P:positive regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000024">
        <property type="entry name" value="TBC1 domain family member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1310:FF:000001">
        <property type="entry name" value="TBC1 domain family, member 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF10">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="9">
        <location>
            <begin position="60"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="403" mass="45917" checksum="C16FC2897BA9FC08" modified="2022-01-19" version="1">MALRSVQGDGLTSSRWDGGAEKTDFNAKRKKKVAEIHQALNSDPTDVAALRRMAISEGGLLTDEIRRKVWPELLNVNTSEPPPISGKDLRQMSKDYQQVLLDVRRSLRRFPPGMPDEQREGLQEELIDIILLILERNPQLHYYQGYHDIVVTFLLVVGERLATSLVEKLSTHHLRDFMDPTMDNTKHILNYLMPIIDRVNPELHDFMQSAEVGTIFALSWLITWFGHVLSDFRHVVRLYDFFLACHPLMPIYFAAVIVLHREQEVLDCDCDMASVHHLLSQIPQDLPYETLISRAGDLFVQFPPSELARAAAAQQQAERTAASTFKDFELASAQQRPDMVLRQRFRGLVRTEDRTKDVLTKPRTNRFVKLAVMGLTVALGAAALAVVKSALEWAPKFQLQLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FQJ8</accession>
    <name>A0A8B7FQJ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Receptor activity-modifying protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">RAMP1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB. Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of CALCRL and RAMP1; the interaction induces allosteric modulation of CALCRL function and CGRP1/CALCA and CGRP2/CALCB ligand specificity. Heterodimer of CALCR and RAMP1; interaction forms the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA ligands.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010502">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010506">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611161.1">
        <property type="nucleotide sequence ID" value="XM_012755707.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FQJ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000070117.1">
        <property type="protein sequence ID" value="ENSMICP00000049687.1"/>
        <property type="gene ID" value="ENSMICG00000047662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866420"/>
    <dbReference type="KEGG" id="mmur:105866420"/>
    <dbReference type="CTD" id="10267"/>
    <dbReference type="GeneTree" id="ENSGT00940000159224"/>
    <dbReference type="OrthoDB" id="10007519at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990406">
        <property type="term" value="C:CGRP receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097643">
        <property type="term" value="F:amylin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990407">
        <property type="term" value="F:calcitonin gene-related peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001635">
        <property type="term" value="F:calcitonin gene-related peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015026">
        <property type="term" value="F:coreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150059">
        <property type="term" value="P:amylin receptor 1 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990408">
        <property type="term" value="P:calcitonin gene-related peptide receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.510:FF:000002">
        <property type="entry name" value="Receptor activity-modifying protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.510">
        <property type="entry name" value="Receptor activity modifying family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006985">
        <property type="entry name" value="RAMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038126">
        <property type="entry name" value="RAMP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14076">
        <property type="entry name" value="RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14076:SF3">
        <property type="entry name" value="RECEPTOR ACTIVITY-MODIFYING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04901">
        <property type="entry name" value="RAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133655" description="Receptor activity-modifying protein 1" evidence="15">
        <location>
            <begin position="27"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="148" mass="16452" checksum="15597E2CB5D867AE" modified="2022-01-19" version="1">MARGTRGFPHRGLWLLLGHLVSLVTACREADLGTLLQDLCLPQFKVDMEAVGEKLWCDWGKTIRSYGELTNCTGLAAGKLGCFWPNAEVDKFFIAVHQRYFRSCPVSGRAVQDPPHSVLCPFIVVPILVTLLVTALVVWRSKRTEGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FUW7</accession>
    <name>A0A8B7FUW7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SSH3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 16">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein-tyrosine phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03006022">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612983.1">
        <property type="nucleotide sequence ID" value="XM_012757529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FUW7"/>
    <dbReference type="Ensembl" id="ENSMICT00000037598.2">
        <property type="protein sequence ID" value="ENSMICP00000033184.2"/>
        <property type="gene ID" value="ENSMICG00000004087.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867466"/>
    <dbReference type="CTD" id="54961"/>
    <dbReference type="GeneTree" id="ENSGT00940000160322"/>
    <dbReference type="OrthoDB" id="5779068at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14571">
        <property type="entry name" value="DSP_slingshot_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000004">
        <property type="entry name" value="Protein phosphatase Slingshot homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043587">
        <property type="entry name" value="Phosphatase_SSH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043588">
        <property type="entry name" value="SSH-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45864">
        <property type="entry name" value="SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23040">
        <property type="entry name" value="PH_SSH1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="13">
        <location>
            <begin position="266"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="325"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="12">
        <location>
            <begin position="390"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="558"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="619"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033184.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="656" mass="72633" checksum="7B58EAD4DFFCB49D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FZD6</accession>
    <name>A0A8B7FZD6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dynein axonemal assembly factor 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HEAT repeat-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DNAAF5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with DNAI2; probably involved in outer arm dynein assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNAAF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021029">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614546.1">
        <property type="nucleotide sequence ID" value="XM_012759092.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FZD6"/>
    <dbReference type="Ensembl" id="ENSMICT00000065184.1">
        <property type="protein sequence ID" value="ENSMICP00000049485.1"/>
        <property type="gene ID" value="ENSMICG00000044352.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105868352"/>
    <dbReference type="KEGG" id="mmur:105868352"/>
    <dbReference type="CTD" id="54919"/>
    <dbReference type="GeneTree" id="ENSGT00390000005666"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000547">
        <property type="entry name" value="Dynein assembly factor 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001468">
        <property type="entry name" value="Dynein, axonemal, assembly factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00063859"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078800"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="5 7" type="primary">DDHD2</name>
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        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
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                <consortium name="The Genome Assembly Team"/>
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                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
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                <consortium name="RefSeq"/>
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            <tissue evidence="7">Liver</tissue>
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    <reference evidence="5" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the PA-PLA1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GBW8</accession>
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    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012619683.1">
        <property type="nucleotide sequence ID" value="XM_012764229.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000025085.2"/>
        <property type="gene ID" value="ENSMICG00000031683.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871081"/>
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    <dbReference type="GeneTree" id="ENSGT00940000162332"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000823">
        <property type="entry name" value="replication initiator 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000277">
        <property type="entry name" value="Zinc finger protein 48"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000418">
        <property type="entry name" value="zinc finger protein 48"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000950">
        <property type="entry name" value="Zinc finger protein 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001245">
        <property type="entry name" value="zinc finger protein 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001305">
        <property type="entry name" value="Zinc finger protein 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
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    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF100">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="141"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="276"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="545"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="159"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="494"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="600"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="175"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="397"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="416"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="606"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025085.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="620" mass="68117" checksum="575397AA97F9F7A9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GXY9</accession>
    <name>A0A8B7GXY9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 512B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF512B</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628478.1">
        <property type="nucleotide sequence ID" value="XM_012773024.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GXY9"/>
    <dbReference type="Ensembl" id="ENSMICT00000028796.2">
        <property type="protein sequence ID" value="ENSMICP00000016830.2"/>
        <property type="gene ID" value="ENSMICG00000028104.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875764"/>
    <dbReference type="KEGG" id="mmur:105875764"/>
    <dbReference type="CTD" id="57473"/>
    <dbReference type="GeneTree" id="ENSGT00940000159165"/>
    <dbReference type="OrthoDB" id="7463797at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902894">
        <property type="term" value="P:negative regulation of miRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Zinc finger protein 512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000270">
        <property type="entry name" value="Zinc finger protein 512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000820">
        <property type="entry name" value="Zinc finger protein 512B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000857">
        <property type="entry name" value="Zinc finger protein 512B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052274">
        <property type="entry name" value="Krueppel_C2H2_Zn-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048408">
        <property type="entry name" value="ZNF512_C2HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22979:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 512B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22979">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21276">
        <property type="entry name" value="ZNF512_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="552"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="796"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="342"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="824"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="831"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="844"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="862"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="893"/>
            <end position="904"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016830.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="904" mass="98659" checksum="ECD20F6D78C78DAC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H5I2</accession>
    <name>A0A8B7H5I2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RAB3B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001482">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631678.1">
        <property type="nucleotide sequence ID" value="XM_012776224.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631679.1">
        <property type="nucleotide sequence ID" value="XM_012776225.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631681.1">
        <property type="nucleotide sequence ID" value="XM_012776227.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145010.1">
        <property type="nucleotide sequence ID" value="XM_020289421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H5I2"/>
    <dbReference type="Ensembl" id="ENSMICT00000039004.2">
        <property type="protein sequence ID" value="ENSMICP00000023541.1"/>
        <property type="gene ID" value="ENSMICG00000036580.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105877550"/>
    <dbReference type="KEGG" id="mmur:105877550"/>
    <dbReference type="CTD" id="5865"/>
    <dbReference type="GeneTree" id="ENSGT00940000159943"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098691">
        <property type="term" value="C:dopaminergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051586">
        <property type="term" value="P:positive regulation of dopamine uptake involved in synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098693">
        <property type="term" value="P:regulation of synaptic vesicle cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097494">
        <property type="term" value="P:regulation of vesicle size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="219" mass="24712" checksum="5E5A10532EA5BC0C" modified="2022-01-19" version="1">MASVTDGKTGGKDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVVPTEKGQLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSLDTDPSILGTSKNTRLSDTPPLLQQNCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H7I0</accession>
    <name>A0A8B7H7I0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Dishevelled segment polarity protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DVL2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DSH family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632495.1">
        <property type="nucleotide sequence ID" value="XM_012777041.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H7I0"/>
    <dbReference type="Ensembl" id="ENSMICT00000004316.3">
        <property type="protein sequence ID" value="ENSMICP00000003934.3"/>
        <property type="gene ID" value="ENSMICG00000004315.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877972"/>
    <dbReference type="KEGG" id="mmur:105877972"/>
    <dbReference type="CTD" id="1856"/>
    <dbReference type="GeneTree" id="ENSGT00950000182903"/>
    <dbReference type="OrthoDB" id="10031689at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090103">
        <property type="term" value="P:cochlea morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022007">
        <property type="term" value="P:convergent extension involved in neural plate elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001947">
        <property type="term" value="P:heart looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003151">
        <property type="term" value="P:outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901798">
        <property type="term" value="P:positive regulation of signal transduction by p53 class mediator"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007379">
        <property type="term" value="P:segment specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060071">
        <property type="term" value="P:Wnt signaling pathway, planar cell polarity pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04438">
        <property type="entry name" value="DEP_dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06717">
        <property type="entry name" value="PDZ_Dishevelled-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.130:FF:000001">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000040">
        <property type="entry name" value="segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000014">
        <property type="entry name" value="Segment polarity protein dishevelled homolog DVL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024580">
        <property type="entry name" value="Dishevelled_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008339">
        <property type="entry name" value="Dishevelled_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003351">
        <property type="entry name" value="Dishevelled_protein_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015506">
        <property type="entry name" value="Dsh/Dvl-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008341">
        <property type="entry name" value="DVL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10878:SF8">
        <property type="entry name" value="SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02377">
        <property type="entry name" value="Dishevelled"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12316">
        <property type="entry name" value="Dsh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01760">
        <property type="entry name" value="DISHEVELLED"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01762">
        <property type="entry name" value="DISHEVELLED2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00021">
        <property type="entry name" value="DAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50841">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="10">
        <location>
            <begin position="11"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="8">
        <location>
            <begin position="267"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="9">
        <location>
            <begin position="433"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="558"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="587"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008735"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003934.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="736" mass="79117" checksum="23DAC117C47DEF75" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H9F1</accession>
    <name>A0A8B7H9F1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spindlin interactor and repressor of chromatin binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPINDOC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005871">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633308.1">
        <property type="nucleotide sequence ID" value="XM_012777854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H9F1"/>
    <dbReference type="Ensembl" id="ENSMICT00000016882.3">
        <property type="protein sequence ID" value="ENSMICP00000015384.2"/>
        <property type="gene ID" value="ENSMICG00000016878.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878454"/>
    <dbReference type="CTD" id="144097"/>
    <dbReference type="GeneTree" id="ENSGT00410000025985"/>
    <dbReference type="OrthoDB" id="8962639at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052675">
        <property type="entry name" value="ZnF_transloc-Spindlin_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2700081O15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589:SF1">
        <property type="entry name" value="SPINDLIN INTERACTOR AND REPRESSOR OF CHROMATIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN-DOC-like zinc-finger" evidence="2">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015384.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="381" mass="40864" checksum="3AC2C5C56D0596ED" modified="2022-01-19" version="1">MALKAEGAALDCFEVTLKCEEGEDEEEAVVVAVIPRREPMLRVTQQEKTPPPRPSLLEAGGDGCEELKQQVSWEQEFLVGSSPGGSGRALCMVCGAEIPSPSADTARSHILEQHPHTLDLSPSEKSNILEAWSEGVALLQDVRAEHPSSPNSEAGRDVEPDPDSNPDSSRTPAEIVVLLDSEDNLSLPKRTRPRGLRPLELPAASAAEPGSKKFRGQRWKEPPEEEPVRKKRGRPMTKNLDPDPDPPSPDSPSETFAAPAEVRHFTDGSFPPGFVLQLFSHTQLRAPDSKDSPKEGEVAEGALPQPESPSPAPPPGLRGTLDLQVIRVRMEEPPAVSLLQDWSKHPQGTKSVGAGDTPDWPAVLSESNATVGGEPKAGSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HA28</accession>
    <name>A0A8B7HA28_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="3 13">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MAP3K11</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="13">Homodimerization via the leucine zipper domains is required for autophosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="3 13"/>
    <dbReference type="EMBL" id="ABDC03005855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633552.1">
        <property type="nucleotide sequence ID" value="XM_012778098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HA28"/>
    <dbReference type="Ensembl" id="ENSMICT00000068107.1">
        <property type="protein sequence ID" value="ENSMICP00000049434.1"/>
        <property type="gene ID" value="ENSMICG00000046309.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105878530"/>
    <dbReference type="CTD" id="4296"/>
    <dbReference type="GeneTree" id="ENSGT00940000161064"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004706">
        <property type="term" value="F:JUN kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031435">
        <property type="term" value="F:mitogen-activated protein kinase kinase kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12059">
        <property type="entry name" value="SH3_MLK1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14147">
        <property type="entry name" value="STKc_MLK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000076">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000079">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000085">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035779">
        <property type="entry name" value="MLK1-3_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016231">
        <property type="entry name" value="MLK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF46">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000556">
        <property type="entry name" value="MAPKKK9_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4 16" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SH3" evidence="20">
        <location>
            <begin position="41"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="117"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="536"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="396"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="597"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="675"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="760"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="800"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000556-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000556-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="847" mass="92939" checksum="AA02E2197CA0C490" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HH16</accession>
    <name>A0A8B7HH16_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">POLR1F</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters.</text>
    </comment>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA43 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636460.1">
        <property type="nucleotide sequence ID" value="XM_012781006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HH16"/>
    <dbReference type="Ensembl" id="ENSMICT00000045512.2">
        <property type="protein sequence ID" value="ENSMICP00000024700.1"/>
        <property type="gene ID" value="ENSMICG00000036489.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880187"/>
    <dbReference type="KEGG" id="mmur:105880187"/>
    <dbReference type="CTD" id="221830"/>
    <dbReference type="GeneTree" id="ENSGT00390000005553"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase I subunit RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1060:FF:000001">
        <property type="entry name" value="Twist neighbor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041178">
        <property type="entry name" value="RPA43_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17875">
        <property type="entry name" value="RPA43_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="10">
        <location>
            <begin position="55"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="RPA43 OB" evidence="11">
        <location>
            <begin position="125"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="214"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="37156" checksum="E2DC55714777E995" modified="2022-01-19" version="1">MAAGCSEALRPNTASDGSLVGSAGVLPCLELPTYAAACALVNSRYSCLVAGPHRRHIALSPRYLNRKRTGIREQLDAELLRYSESLLGVPIAYDNIKVVGELGDIYDDQGHIHLNIEADFVIFCPEPGQKLMGTVNKVSSSHIGCLVHGCFNASIPKPELLSAEQWQTLQINLGDELEFEVFRLDSDAAGVFCIRGKLNINSLQFKSSEVSEEVAETGTEEVVEKPPKKKKKKKKDPETYEVDSVTIKQANFADDTPKEELDLQITNNVNGLCEEEPKKKKKKKKKHQEDQDQDPVFQCSDSSGYQSDHKKKKKKRKHNEEAEFTSPKKKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HLF0</accession>
    <name>A0A8B7HLF0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcipressin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Regulator of calcineurin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RCAN1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033139">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638392.1">
        <property type="nucleotide sequence ID" value="XM_012782938.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HLF0"/>
    <dbReference type="Ensembl" id="ENSMICT00000067114.1">
        <property type="protein sequence ID" value="ENSMICP00000041460.1"/>
        <property type="gene ID" value="ENSMICG00000011975.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881315"/>
    <dbReference type="KEGG" id="mmur:105881315"/>
    <dbReference type="CTD" id="1827"/>
    <dbReference type="GeneTree" id="ENSGT00940000159870"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12708">
        <property type="entry name" value="RRM_RCAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000221">
        <property type="entry name" value="calcipressin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034906">
        <property type="entry name" value="RCAN1_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF4">
        <property type="entry name" value="CALCIPRESSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="197" mass="22597" checksum="146F51D39F0B4E08" modified="2022-01-19" version="1">MHFRNFNYSFSSLIACGANSDIFSESETRAKFEALFRTYDKDITFQYFKSFKRVRINFSNPLSAADARLHLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDEEKEEEEEVEKMKRPKPKIIQTRRPEYTPIHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HQX6</accession>
    <name>A0A8B7HQX6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GRB2 associated binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">GAB1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the GAB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018666">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639261.1">
        <property type="nucleotide sequence ID" value="XM_012783807.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HQX6"/>
    <dbReference type="Ensembl" id="ENSMICT00000045333.2">
        <property type="protein sequence ID" value="ENSMICP00000023711.2"/>
        <property type="gene ID" value="ENSMICG00000009956.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881860"/>
    <dbReference type="KEGG" id="mmur:105881860"/>
    <dbReference type="CTD" id="2549"/>
    <dbReference type="GeneTree" id="ENSGT00940000156801"/>
    <dbReference type="OrthoDB" id="67516at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035767">
        <property type="term" value="P:endothelial cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038084">
        <property type="term" value="P:vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01266">
        <property type="entry name" value="PH_Gab1_Gab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000166">
        <property type="entry name" value="GRB2-associated-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046355">
        <property type="entry name" value="Gab1-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45960:SF5">
        <property type="entry name" value="GRB2-ASSOCIATED-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="725"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023711.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="751" mass="82843" checksum="B9C88FD692D8772E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRW0</accession>
    <name>A0A8B7HRW0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm-tail PG-rich repeat containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">STPG3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03015045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639939.1">
        <property type="nucleotide sequence ID" value="XM_012784485.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRW0"/>
    <dbReference type="Ensembl" id="ENSMICT00000045347.2">
        <property type="protein sequence ID" value="ENSMICP00000029997.2"/>
        <property type="gene ID" value="ENSMICG00000010949.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882258"/>
    <dbReference type="KEGG" id="mmur:105882258"/>
    <dbReference type="CTD" id="441476"/>
    <dbReference type="GeneTree" id="ENSGT00390000009524"/>
    <dbReference type="OrthoDB" id="406368at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051291">
        <property type="entry name" value="CIMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010736">
        <property type="entry name" value="SHIPPO-rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580:SF25">
        <property type="entry name" value="PROTEIN STPG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21580">
        <property type="entry name" value="SHIPPO-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07004">
        <property type="entry name" value="SHIPPO-rpt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029997.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="342" mass="37528" checksum="D56519AC8C7BF8F8" modified="2022-01-19" version="1">MLLPRESLATEGSTSEVTELSGGRALGEGSPESLKMNFDQKAVKFLANFYINGGKHWTHGPLRQQPLEPGQPSAVVLLSGSEPGTYWEMWSSKTKEVPAVLRIHRGTTQDFSPTYTQTLRELLLKRRPPIVTDLDVPGPAKYEVPSASVRESSPHPRYSIGHKHQGREGGGRRAWQTPWLQSESPFTQKVDFNREQKWPSPADHVPVSRSACPAFSFGGRRPSSQTAVGQARPRLLGTGVPRLRAQSLIQGSLRAPGERRPAPNTYDILPGCSMQSARSPAFSMSRSPAFASWFRSSQTPGPGPAAYQVEDCYNSCFPSSPGVVIQGVRRPKRHDTGPFCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HYH6</accession>
    <name>A0A8B7HYH6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U5 small nuclear ribonucleoprotein 200 kDa helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">BRR2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">U5 snRNP-specific 200 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21 23" type="primary">SNRNP200</name>
    </gene>
    <organism evidence="23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="23">Liver</tissue>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of a core complex containing at least PRPF8, SNRNP200, EFTUD2 and SNRNP40. Component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes, building blocks of the spliceosome. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39. Component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the minor spliceosome, which splices U12-type introns. Interacts with C9orf78; the interaction is direct and mutually exclusive with its interaction with WBP4. Interacts with WBP4; the interaction is mutually exclusive with its interaction with C9orf78. Interacts with PRPF8. Interacts with TSSC4; the interaction is direct, excludes recruitment of C9ORF78 and WBP4 to SNRNP200 and negatively regulates its RNA helicase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03005338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642347.1">
        <property type="nucleotide sequence ID" value="XM_012786893.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000004748.3">
        <property type="protein sequence ID" value="ENSMICP00000004327.2"/>
        <property type="gene ID" value="ENSMICG00000004710.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883631"/>
    <dbReference type="KEGG" id="mmur:105883631"/>
    <dbReference type="CTD" id="23020"/>
    <dbReference type="GeneTree" id="ENSGT00940000154966"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000388">
        <property type="term" value="P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000048">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 23" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="23" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="490"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="684"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="1337"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="1545"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004327.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="RefSeq" id="XP_012642347.1"/>
        </source>
    </evidence>
    <sequence length="2136" mass="244521" checksum="D70701232190605B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I024</accession>
    <name>A0A8B7I024_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Actin-related protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ACTR6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for formation and/or maintenance of proper nucleolar structure and function. Plays a dual role in the regulation of ribosomal DNA (rDNA) transcription. In the presence of high glucose, maintains active rDNA transcription through H2A.Z deposition and under glucose starvation, is required for the repression of rDNA transcription, and this function may be independent of H2A.Z.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1. Interacts with CBX1, CBX3 and CBX5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643104.1">
        <property type="nucleotide sequence ID" value="XM_012787650.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I024"/>
    <dbReference type="SMR" id="A0A8B7I024"/>
    <dbReference type="Ensembl" id="ENSMICT00000016393.3">
        <property type="protein sequence ID" value="ENSMICP00000014941.3"/>
        <property type="gene ID" value="ENSMICG00000016393.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883963"/>
    <dbReference type="KEGG" id="mmur:105883963"/>
    <dbReference type="CTD" id="64431"/>
    <dbReference type="GeneTree" id="ENSGT00720000108833"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000003">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000599">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000601">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000602">
        <property type="entry name" value="Actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014941.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="396" mass="45782" checksum="67EE7B0D4A4148C8" modified="2022-01-19" version="1">MTTLVLDNGAYNAKIGYSHENVSVIPNCQFRSKTARLKTFTANQIDEIKDPSGLFYILPFQKGYLVNWDVQRQVWDYLFGKEMYQVDFLDTNIIITEPYFNFTSIQESMNEILFEEYQFQAVLRVNAGALSAHRYFRDNPSELCCIIVDSGYSFTHIVPYCRSKKKKEAIIRINVGGKLLTNHLKEIISYRQLHVMDETHVINQVKEDVCYVSQDFYKDMDIAKLKGEENTVMIDYVLPDFSTIKKGFCKPREEMVLSGKYKSGEQILRLANERFAVPEILFNPSDIGIQEMGIPEAIVYSIQNLPEEMQPHFFKNIVLTGGNSLFPGFRDRVYSEVRCLTPTDYDVSVVLPENPITYAWEGGKLISENDDFEDMVVTREDYEENGHSVCEEKFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I3S9</accession>
    <name>A0A8B7I3S9_MICMU</name>
    <protein>
        <submittedName>
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        <name evidence="11" type="primary">PRRT4</name>
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    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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</entry>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
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                <person name="Lee S."/>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="255"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="284"/>
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
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        <location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
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            <begin position="33"/>
            <end position="44"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        </source>
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        <source>
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        </source>
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        </source>
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        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049849.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Stimulator of chondrosis 1</fullName>
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        <name evidence="2" type="primary">SCRG1</name>
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        <name type="scientific">Microcebus murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_020280247.2"/>
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    </dbReference>
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        <property type="component" value="Chromosome 14"/>
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        </location>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007840.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="98" mass="11106" checksum="F8CCA56D7E87D4D8" modified="2022-01-19" version="1">MKFMVLAVIVGLTLLLGIQAMPANRLSCYRKILKDRNCHNLPEGVPDLTQIDVNVQDHFWDGKGCEMICYCNFNELLCCPKDIFFGPKISFVIPCNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WKQ6</accession>
    <name>A0A8B7WKQ6_MICMU</name>
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        <recommendedName>
            <fullName evidence="21">Metalloendopeptidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">TLL1</name>
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    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
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                <person name="Reid J.G."/>
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                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="20 21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="20 21">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03018883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018884">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135857.1">
        <property type="nucleotide sequence ID" value="XM_020280268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WKQ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000062776.1">
        <property type="protein sequence ID" value="ENSMICP00000048372.1"/>
        <property type="gene ID" value="ENSMICG00000007263.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157225"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00041">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04281">
        <property type="entry name" value="ZnMc_BMP1_TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000022">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000004">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000007">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000009">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000011">
        <property type="entry name" value="Metalloendopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.290:FF:000005">
        <property type="entry name" value="Procollagen C-endopeptidase enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.290">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015446">
        <property type="entry name" value="BMP_1/tolloid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000859">
        <property type="entry name" value="CUB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034036">
        <property type="entry name" value="ZnMP_TLD/BMP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251:SF45">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24251">
        <property type="entry name" value="OVOCHYMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00431">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001199">
        <property type="entry name" value="BMP_1/tolloid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00042">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01180">
        <property type="entry name" value="CUB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="15 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 20 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 18 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 20 21" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 20 21" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="11 18 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044038292" description="Metalloendopeptidase" evidence="21">
        <location>
            <begin position="23"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="25">
        <location>
            <begin position="148"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="349"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="462"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="618"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="24">
        <location>
            <begin position="730"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="774"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="23">
        <location>
            <begin position="887"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="120"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="17 20">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 20">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001199-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113332" checksum="73791E5FD690F92D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X509</accession>
    <name>A0A8B7X509_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Glucose 1,6-bisphosphate synthase</fullName>
            <ecNumber evidence="16">2.7.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Phosphoglucomutase-2-like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PGM2L1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Glucose 1,6-bisphosphate synthase using 1,3-bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1-phosphate, as acceptors. In vitro, also exhibits very low phosphopentomutase and phosphoglucomutase activity which are most probably not physiologically relevant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-3-phospho-glyceroyl phosphate + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16769"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.1.106"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16770"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R)-3-phospho-glyceroyl phosphate + alpha-D-mannose 1-phosphate = alpha-D-mannose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70907"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:190127"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:70908"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70899"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:68688"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:70900"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70903"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:190126"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:70904"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>alpha-D-glucose 6-phosphate + (2R)-3-phospho-glyceroyl phosphate = alpha-D-glucose 1,6-bisphosphate + (2R)-3-phosphoglycerate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70911"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70912"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.106" evidence="16"/>
    <dbReference type="EMBL" id="ABDC03006511">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006512">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142200.1">
        <property type="nucleotide sequence ID" value="XM_020286611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X509"/>
    <dbReference type="Ensembl" id="ENSMICT00000040026.2">
        <property type="protein sequence ID" value="ENSMICP00000032060.2"/>
        <property type="gene ID" value="ENSMICG00000002256.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105860379"/>
    <dbReference type="CTD" id="283209"/>
    <dbReference type="GeneTree" id="ENSGT00940000158353"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047933">
        <property type="term" value="F:glucose-1,6-bisphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000016">
        <property type="entry name" value="Glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000017">
        <property type="entry name" value="glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000018">
        <property type="entry name" value="Glucose 1,6-bisphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF2">
        <property type="entry name" value="GLUCOSE 1,6-BISPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="65"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="20">
        <location>
            <begin position="238"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="21">
        <location>
            <begin position="354"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00070753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00075074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032060.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="619" mass="70276" checksum="38E205F864CC0F94" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XCL8</accession>
    <name>A0A8B7XCL8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">snRNA-activating protein complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Small nuclear RNA-activating complex polypeptide 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SNAPC3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014556">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144935.1">
        <property type="nucleotide sequence ID" value="XM_020289346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XCL8"/>
    <dbReference type="Ensembl" id="ENSMICT00000013907.3">
        <property type="protein sequence ID" value="ENSMICP00000012683.2"/>
        <property type="gene ID" value="ENSMICG00000013886.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874114"/>
    <dbReference type="CTD" id="6619"/>
    <dbReference type="GeneTree" id="ENSGT00390000005708"/>
    <dbReference type="OrthoDB" id="46583at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012683.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="412" mass="47019" checksum="704D35701B3B36D5" modified="2022-01-19" version="1">MAEGGLGGPTCSGVRSRQDPVPNTGGCNFPEYELPELNTRAFHVGGFGELWRGRLRGAGDLSLREPPTPALPGRGEVADSDREDAAVARDLGCSLEAAAELRAVCGLDKLKCFEEGEDPEVIPEDTDLVTLGIRKKFLEHREETITIDRVCRQETFAYEMESHAIGKKPGNPADMIEEGELILSVNILYPVIFHKHKEHKPYQTMLVLGSQKLTELRDSIRCVSDLQIGGEFSNTPDQAPEHISKDLYKSAFFYFEGTFYNDKRYPECRDLSRTIVEWSESHDRGYGKFQTARMEDFTFNDLYIKLGFPYLYCHQGDCEHVVVITDIRLVHHDDCLDRTLYPLLIKKHWLWTRKCFVCKMYTARWVTNNDSFAPEDPCFFCDVCFRMLHYDSEGNKLGEFLAYPYVDPGTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UK13</accession>
    <name>A0A8C5UK13_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Acyl-coenzyme A thioesterase 13</fullName>
            <ecNumber evidence="15">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ACOT13</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:40140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octanoyl-CoA + H2O = octanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:30144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
            <location evidence="4">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03018569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UK13"/>
    <dbReference type="Ensembl" id="ENSMICT00000000040.3">
        <property type="protein sequence ID" value="ENSMICP00000000037.2"/>
        <property type="gene ID" value="ENSMICG00000000041.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013934"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="29">
        <location>
            <begin position="27"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000037.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="115" mass="12220" checksum="8BF1B2D3107A6B17" modified="2022-01-19" version="1">RKVTVVSAVPGKVVCEMKVEEEHTNRMGTLHGGLTATLVDDISTVALLCTERGLPGVSVDMNITYMSPAKIGEDVVITAHILKQGRTLAFASVDLTNKATGKLVAQGRHTKHLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNS1</accession>
    <name>A0A8C5UNS1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tight junction protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Tight junction protein ZO-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Zona occludens protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Zonula occludens protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TJP2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in tight junctions and adherens junctions. Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAGUK family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNS1"/>
    <dbReference type="Ensembl" id="ENSMICT00000002909.3">
        <property type="protein sequence ID" value="ENSMICP00000002651.3"/>
        <property type="gene ID" value="ENSMICG00000002908.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158634"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045216">
        <property type="term" value="P:cell-cell junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090557">
        <property type="term" value="P:establishment of endothelial intestinal barrier"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034109">
        <property type="term" value="P:homotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050892">
        <property type="term" value="P:intestinal absorption"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905605">
        <property type="term" value="P:positive regulation of blood-brain barrier permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150105">
        <property type="term" value="P:protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090559">
        <property type="term" value="P:regulation of membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06727">
        <property type="entry name" value="PDZ1_ZO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06728">
        <property type="entry name" value="PDZ2_ZO1-like_ds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06729">
        <property type="entry name" value="PDZ3_ZO1-like_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12027">
        <property type="entry name" value="SH3_ZO-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000009">
        <property type="entry name" value="Putative tight junction protein ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000013">
        <property type="entry name" value="Putative tight junction protein ZO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000110">
        <property type="entry name" value="tight junction protein ZO-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000081">
        <property type="entry name" value="Tight junction protein ZO-2 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000075">
        <property type="entry name" value="Tight junction protein ZO-2 isoform 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
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    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
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    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="SH3-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
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    <dbReference type="InterPro" id="IPR005417">
        <property type="entry name" value="ZO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005419">
        <property type="entry name" value="ZO-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035598">
        <property type="entry name" value="ZO-2_SH3"/>
    </dbReference>
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        <property type="entry name" value="TIGHT JUNCTION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIGHT JUNCTION PROTEIN ZO-2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Guanylate_kin"/>
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        <property type="entry name" value="SH3_2"/>
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        <property type="entry name" value="ZONOCCLUDNS"/>
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        <property type="entry name" value="ZONOCCLUDNS2"/>
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        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PDZ domain-like"/>
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    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ"/>
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    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="93"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="357"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="23">
        <location>
            <begin position="559"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="654"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="22">
        <location>
            <begin position="824"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="213"/>
            <end position="358"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="459"/>
            <end position="554"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="970"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1161"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="213"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="465"/>
            <end position="496"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1006"/>
            <end position="1021"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
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            <begin position="1104"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00053250"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075184"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077376"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081577"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002651.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138435" checksum="662DCF8522977346" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQ72</accession>
    <name>A0A8C5UQ72_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NOP16</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQ72"/>
    <dbReference type="Ensembl" id="ENSMICT00000004019.3">
        <property type="protein sequence ID" value="ENSMICP00000003663.3"/>
        <property type="gene ID" value="ENSMICG00000004020.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163830"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003663.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="150" mass="17289" checksum="3BECCFD988C5540D" modified="2022-01-19" version="1">MPKAKGKTRRQKFGYNVNRKRLNRNARRKAAPRIECSHIRHAWDHGKSSVRQNLAEMGLAVDPNRALPLRKRKVKAMEVDLEERPKELVRKPYVLNDLEAEASLPEKKGNTLSRDLIDYVRYMVENHGEDYKVSGRTTGRLGWCPGPCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5US87</accession>
    <name>A0A8C5US87_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TCP11</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007465">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5US87"/>
    <dbReference type="Ensembl" id="ENSMICT00000005056.3">
        <property type="protein sequence ID" value="ENSMICP00000004611.3"/>
        <property type="gene ID" value="ENSMICG00000005056.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161869"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007281">
        <property type="term" value="P:germ cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902490">
        <property type="term" value="P:regulation of sperm capacitation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF14">
        <property type="entry name" value="T-COMPLEX PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004611.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="464" mass="51885" checksum="BB18A959643A8E1B" modified="2022-01-19" version="1">VPSGRGGVLTETVNEVSKLSNKIGMNHDYHMEEKIVPPSSLEGKVKETMHNAFWDHLKEQLSAAPPDFSCALELLKEIKEILLSLLLPRQNRLRTEIEEALDMNFLKQKAEDGTLDVPYLSKYILNMMTLLCAPVRDEAVQKLEHVTDPAQLLRGIFQVLGLMKMDMVNYTIQSLQPHLQEHSIQYERAKFQEQLDEQPGLLNHTTKWLTKAAADLTTPPPTCPDMPDSTSVAGPSPNQPANNPEPLSPSMVLSQGFLNLLLWDPQNEEFPETLLMDRTRLQELESQLHQLTVLASVLLVASSFSGSVLFGSPQFVDKLKRITRSLLEDFNSRPEEAMLTVSEQVSQEIHQSLKNMGLAALSSDNTASLIGQLQNIAKKENCVRSVIDQRIHLFLKCCLVLGVQRSLLDLPGGLTLIEAELAELGQKFVNLTHHNQQVFGPYYTEILKTLTSPAQALETKVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTR0</accession>
    <name>A0A8C5UTR0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dipeptidyl peptidase 2</fullName>
            <ecNumber evidence="18">3.4.14.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Dipeptidyl aminopeptidase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Dipeptidyl peptidase 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Dipeptidyl peptidase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Quiescent cell proline dipeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">DPP7</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Plays an important role in the degradation of some oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides.</text>
            <dbReference type="EC" id="3.4.14.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.2" evidence="18"/>
    <dbReference type="EMBL" id="ABDC03015042">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639933.1">
        <property type="nucleotide sequence ID" value="XM_012784479.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UTR0"/>
    <dbReference type="Ensembl" id="ENSMICT00000006202.3">
        <property type="protein sequence ID" value="ENSMICP00000005655.2"/>
        <property type="gene ID" value="ENSMICG00000006205.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882253"/>
    <dbReference type="KEGG" id="mmur:105882253"/>
    <dbReference type="CTD" id="29952"/>
    <dbReference type="GeneTree" id="ENSGT00940000159838"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905146">
        <property type="term" value="P:lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000484">
        <property type="entry name" value="Dipeptidyl peptidase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF107">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00057675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00066778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00080970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00081307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005655.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="535" mass="58736" checksum="9903D25909C1512F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UUE6</accession>
    <name>A0A8C5UUE6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement component C9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">C9</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Constitutes the pore-forming subunit of the MAC complex: during MAC assembly, C9 associates with the C5b8 intermediate complex, and polymerizes to complete the pore.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homooligomer; about 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes. Component of the membrane attack complex (MAC), composed of complement C5b, C6, C7, C8A, C8B, C8G and multiple copies of the pore-forming subunit C9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complement C6/C7/C8/C9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591944.1">
        <property type="nucleotide sequence ID" value="XM_012736490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UUE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000006717.3">
        <property type="protein sequence ID" value="ENSMICP00000006127.2"/>
        <property type="gene ID" value="ENSMICG00000006710.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855476"/>
    <dbReference type="KEGG" id="mmur:105855476"/>
    <dbReference type="CTD" id="735"/>
    <dbReference type="GeneTree" id="ENSGT00940000159777"/>
    <dbReference type="OrthoDB" id="10037824at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005579">
        <property type="term" value="C:membrane attack complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902495">
        <property type="term" value="C:transmembrane transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006957">
        <property type="term" value="P:complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160257">
        <property type="term" value="P:complement activation, GZMK pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000766">
        <property type="entry name" value="Complement component C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000089">
        <property type="entry name" value="Complement component C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001862">
        <property type="entry name" value="MAC_perforin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742:SF3">
        <property type="entry name" value="COMPLEMENT COMPONENT C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00764">
        <property type="entry name" value="COMPLEMENTC9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00457">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00279">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51412">
        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0179">Complement alternate pathway</keyword>
    <keyword evidence="14" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="12" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="17 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0473">Membrane attack complex</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="20" id="KW-1053">Target membrane</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149894" description="Complement component C9" evidence="24">
        <location>
            <begin position="29"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="25">
        <location>
            <begin position="138"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00093294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006127.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="551" mass="61861" checksum="328D082853610ACF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UV55</accession>
    <name>A0A8C5UV55_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">E3 ubiquitin-protein ligase TRIM47</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Tripartite motif-containing protein 47</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TRIM47</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03019877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634300.1">
        <property type="nucleotide sequence ID" value="XM_012778846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UV55"/>
    <dbReference type="Ensembl" id="ENSMICT00000007657.3">
        <property type="protein sequence ID" value="ENSMICP00000006966.3"/>
        <property type="gene ID" value="ENSMICG00000007653.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878954"/>
    <dbReference type="KEGG" id="mmur:105878954"/>
    <dbReference type="CTD" id="91107"/>
    <dbReference type="GeneTree" id="ENSGT00940000154334"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19769">
        <property type="entry name" value="Bbox2_TRIM16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15808">
        <property type="entry name" value="SPRY_PRY_TRIM47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000045">
        <property type="entry name" value="E3 ubiquitin/ISG15 ligase TRIM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001413">
        <property type="entry name" value="tripartite motif-containing protein 47 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000375">
        <property type="entry name" value="tripartite motif-containing protein 47 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042780">
        <property type="entry name" value="TRIM47_SPRY_PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058030">
        <property type="entry name" value="TRIM8/14/16/25/29/45/65_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF21">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25600">
        <property type="entry name" value="TRIM_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15227">
        <property type="entry name" value="zf-C3HC4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="22">
        <location>
            <begin position="9"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="23">
        <location>
            <begin position="179"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="24">
        <location>
            <begin position="412"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00076777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006966.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="640" mass="69676" checksum="012ED858958CBEF3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVK4</accession>
    <name>A0A8C5UVK4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CD9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616069.1">
        <property type="nucleotide sequence ID" value="XM_012760615.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000009231.3">
        <property type="protein sequence ID" value="ENSMICP00000008407.2"/>
        <property type="gene ID" value="ENSMICG00000009235.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869055"/>
    <dbReference type="KEGG" id="mmur:105869055"/>
    <dbReference type="CTD" id="928"/>
    <dbReference type="GeneTree" id="ENSGT00940000155083"/>
    <dbReference type="OrthoDB" id="5870230at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071404">
        <property type="term" value="P:cellular response to low-density lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007342">
        <property type="term" value="P:fusion of sperm to egg plasma membrane involved in single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008347">
        <property type="term" value="P:glial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014905">
        <property type="term" value="P:myoblast fusion involved in skeletal muscle regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090331">
        <property type="term" value="P:negative regulation of platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030913">
        <property type="term" value="P:paranodal junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905521">
        <property type="term" value="P:regulation of macrophage migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035036">
        <property type="term" value="P:sperm-egg recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03152">
        <property type="entry name" value="CD9_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000016">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042055">
        <property type="entry name" value="CD9_LEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF163">
        <property type="entry name" value="CD9 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0278">Fertilization</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008407.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="228" mass="25234" checksum="F1EC6E10C93045D4" modified="2022-01-19" version="1">MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYSHKDEVIKDIQEMYEDTYNKLKSKEGPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDILDSLTVKPCPAAIRDVFENKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2C7</accession>
    <name>A0A8C5V2C7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DnaJ homolog subfamily B member 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Testis and spermatogenesis cell-related protein 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Testis spermatocyte apoptosis-related gene 6 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Testis spermatogenesis apoptosis-related gene 3 protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Testis spermatogenesis apoptosis-related gene 6 protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DNAJB13</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Interacts with SUN5. Interacts with IQUB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600314.1">
        <property type="nucleotide sequence ID" value="XM_012744860.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2C7"/>
    <dbReference type="Ensembl" id="ENSMICT00000012675.3">
        <property type="protein sequence ID" value="ENSMICP00000011544.2"/>
        <property type="gene ID" value="ENSMICG00000012675.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860296"/>
    <dbReference type="KEGG" id="mmur:105860296"/>
    <dbReference type="CTD" id="374407"/>
    <dbReference type="GeneTree" id="ENSGT00940000158090"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904158">
        <property type="term" value="P:axonemal central apparatus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000033">
        <property type="entry name" value="dnaJ homolog subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF519">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="14">
        <location>
            <begin position="4"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00078669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011544.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="316" mass="36088" checksum="528BEEE19ED1DB55" modified="2022-01-19" version="1">MGQDYYAVLQITRNAEDAQIKKAYRKLALRNHPLKSSEPISVEIFKQIAEAYDVLSDPVKRSIYDKFGEEGLKGGIPLEFGSQTPWTTGYVFHGNPEKVFHEFFGGDNPFSEFFDSEGIEVDLNFGGLRGRGVKKQDPPIERDLYLSLEDLFFGCTKKIKISRRVLNEDGYSSTIKDKILTIDVKPGWRQGTRITFEKEGDQGPNVIPADIIFIVKEKLHPRFRRENDNLFFVSPIPLGKALTCCTVEVKTLDDRLLNIPINDIVHPKYFKKVPGEGMPLPEDPTKKGDLFIFFDIQFPTRLTPQKKQMLRQALLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6X0</accession>
    <name>A0A8C5V6X0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PSMB8</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Component of the immunoproteasome, where it displaces the equivalent housekeeping subunit PSMB5. Component of the spermatoproteasome, a form of the proteasome specifically found in testis. Directly interacts with POMP. Interacts with TAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646841.1">
        <property type="nucleotide sequence ID" value="XM_012791387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6X0"/>
    <dbReference type="Ensembl" id="ENSMICT00000015249.3">
        <property type="protein sequence ID" value="ENSMICP00000013909.1"/>
        <property type="gene ID" value="ENSMICG00000015254.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105886024"/>
    <dbReference type="KEGG" id="mmur:105886024"/>
    <dbReference type="CTD" id="5696"/>
    <dbReference type="GeneTree" id="ENSGT00940000157293"/>
    <dbReference type="OMA" id="IQIEMAH"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000038">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF8">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="278" mass="30681" checksum="F583D6EBEBB3250E" modified="2022-01-19" version="1">MALLDVCGAPRGRGRRPDWALPGAGSRPGSGPGHYSFSVRSPELALPRGMQPTEFFQSLSGDRERNIRIEMAHGTTTLAFKFQHGVIVAVDSRASAGNYIATLLVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGLGLSMGSMICGWDKKGPGLYYVNEYGTRLSGNMFSTGSGNSYAYGVMDSGYRPNLSPKEAYDLGRRAIVHATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9Y5</accession>
    <name>A0A8C5V9Y5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
            <ecNumber evidence="15">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PLCB3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:43485"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33180"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03005869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9Y5"/>
    <dbReference type="Ensembl" id="ENSMICT00000016973.3">
        <property type="protein sequence ID" value="ENSMICP00000015469.3"/>
        <property type="gene ID" value="ENSMICG00000016970.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160539"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16210">
        <property type="entry name" value="EFh_PI-PLCbeta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08625">
        <property type="entry name" value="PI-PLCc_beta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000048">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1230.10:FF:000003">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.240:FF:000007">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000008">
        <property type="entry name" value="1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.240">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1230.10">
        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042531">
        <property type="entry name" value="PLC-beta_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037862">
        <property type="entry name" value="PLC-beta_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053945">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF11">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17787">
        <property type="entry name" value="PH_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08703">
        <property type="entry name" value="PLC-beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22631">
        <property type="entry name" value="PLCB1-4-like_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000956">
        <property type="entry name" value="PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69989">
        <property type="entry name" value="C-terminal domain of PLC-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15 18" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="9 15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="22">
        <location>
            <begin position="512"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="21">
        <location>
            <begin position="629"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="399"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="471"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="807"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1121"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="983"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="815"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000956-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015469.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1156" mass="130463" checksum="801179DD14B33FAA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAZ6</accession>
    <name>A0A8C5VAZ6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Contactin associated protein family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CNTNAP4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000032872.2">
        <property type="protein sequence ID" value="ENSMICP00000017107.2"/>
        <property type="gene ID" value="ENSMICG00000012242.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157674"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1000:FF:000005">
        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000088">
        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000026">
        <property type="entry name" value="contactin-associated protein-like 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF40">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034321498" evidence="15">
        <location>
            <begin position="26"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1241"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="16">
        <location>
            <begin position="31"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="183"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="370"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="549"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="19">
        <location>
            <begin position="585"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="793"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="959"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="17">
        <location>
            <begin position="1009"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="931"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017107.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1308" mass="144780" checksum="8D3C6373CB9DB7D8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VB42</accession>
    <name>A0A8C5VB42_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PFKFB4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018184">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626634.1">
        <property type="nucleotide sequence ID" value="XM_012771180.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VB42"/>
    <dbReference type="Ensembl" id="ENSMICT00000028931.2">
        <property type="protein sequence ID" value="ENSMICP00000018972.2"/>
        <property type="gene ID" value="ENSMICG00000026538.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874928"/>
    <dbReference type="CTD" id="5210"/>
    <dbReference type="GeneTree" id="ENSGT00950000182835"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000001">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000047">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF14">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="11">
        <location>
            <begin position="35"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="256"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018972.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="469" mass="54077" checksum="C4CBC672C2E0F512" modified="2022-01-19" version="1">MASPRELTQNPLKKIWMPYSNGRPALHACPRGVCMTNCPTLIVMVGLPARGKTYISKKLTRYLNWIGVPTREFNVGQYRRDMVKTYRSFEFFLPNNEEGLKIRKQCALAALRDVRRFLSEEGGHVAVFDATNTTRERRATIFNFGEQNGYKTFFVESICVDPEVIAANIVQVKLGSPDYVNRDSDEATEDFMRRIECYENSYESLDEDLDRDLSYIKIMDVGQSYVVNRVADHIQSRIVYYLMNIHVTPRSIYLCRHGESELNLKGRIGGDPGLSPRGREFAKSLAKFISDQNIKDLKVWTSQMKRTIQTAEALGVPYEQWKVLNEIDAGVCEEMTYEEIQDHYPLEFALRDQDKYRYRYPKGESYEDLVQRLEPVIMELERQENVLVVCHQAVMRCLLAYFLDKAAEQLPYLKCPLHTVLKLTPVAYGCKVESIFLNVAAVNTHRDRPQNVDISRPPEEALVTVPAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBA9</accession>
    <name>A0A8C5VBA9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="23">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ITCH</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 23">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">(Microbial infection) Interacts with Epstein-Barr virus LMP2A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="23"/>
    <dbReference type="EMBL" id="ABDC03021619">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021620">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021621">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610129.1">
        <property type="nucleotide sequence ID" value="XM_012754675.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610130.1">
        <property type="nucleotide sequence ID" value="XM_012754676.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBA9"/>
    <dbReference type="Ensembl" id="ENSMICT00000054254.2">
        <property type="protein sequence ID" value="ENSMICP00000017284.2"/>
        <property type="gene ID" value="ENSMICG00000003238.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865825"/>
    <dbReference type="KEGG" id="mmur:105865825"/>
    <dbReference type="CTD" id="83737"/>
    <dbReference type="GeneTree" id="ENSGT00940000157014"/>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050687">
        <property type="term" value="P:negative regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002683">
        <property type="term" value="P:negative regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein K48-linked ubiquitination"/>
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        <property type="term" value="P:protein K63-linked ubiquitination"/>
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        <property type="term" value="P:symbiont entry into host cell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd04021">
        <property type="entry name" value="C2_E3_ubiquitin_ligase"/>
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        <property type="entry name" value="HECTc"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
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    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000063">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="C2_domain_sf"/>
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        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
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        <property type="entry name" value="E3_ubiq-protein_ligase"/>
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        <property type="entry name" value="HECT_dom"/>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
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        <property type="entry name" value="WW_dom"/>
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    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ITCHY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HECT"/>
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        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="WW_DOMAIN_2"/>
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    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="12" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0967">Endosome</keyword>
    <keyword evidence="17" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="15 23 25" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="28">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="28">
        <location>
            <begin position="315"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="28">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="28">
        <location>
            <begin position="435"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="29">
        <location>
            <begin position="526"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="152"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="26">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="24 25">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00064638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017284.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="860" mass="98504" checksum="D1964696EFF79207" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDP6</accession>
    <name>A0A8C5VDP6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Defender against cell death 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DAD/OST2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020048">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDP6"/>
    <dbReference type="Ensembl" id="ENSMICT00000039050.2">
        <property type="protein sequence ID" value="ENSMICP00000020591.2"/>
        <property type="gene ID" value="ENSMICG00000029601.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000171663"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020591.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="79" mass="8769" checksum="B0CD4EAA9350208D" modified="2022-01-19" version="1">TSASVVSVISRFLEEYLSSAPQRLKLLDGYLLYILLTGNTDQPTEQSRFPRHLPGAERAFAGFLFASTILHLVVKNFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEY7</accession>
    <name>A0A8C5VEY7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MGAT4 conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC105860069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 54 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VEY7"/>
    <dbReference type="Ensembl" id="ENSMICT00000035819.2">
        <property type="protein sequence ID" value="ENSMICP00000018408.1"/>
        <property type="gene ID" value="ENSMICG00000035809.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163751"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008375">
        <property type="term" value="F:acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006759">
        <property type="entry name" value="Glyco_transf_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057279">
        <property type="entry name" value="MGAT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062:SF11">
        <property type="entry name" value="ALPHA-1,3-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE PROTEIN MGAT4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12062">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYLTRANSFERASE VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04666">
        <property type="entry name" value="MGAT4_cons"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034352853" description="MGAT4 conserved region domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="MGAT4 conserved region" evidence="6">
        <location>
            <begin position="56"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="444" mass="50755" checksum="0DF414EF5ECBC057" modified="2022-01-19" version="1">MRCSIRRCLITSVSILFLWLFITMQVLQETEDDQEAMTIKGQASHGSRKDLRQLEDWQNITLKYMEKIQRRKRTWLTVGISSLSQGNGSRLLTTLISLFHISSKTERKHLTVVVHLADSDLTWLRETVAHISNLFSPQIVAGQLLLIHAPPDAYPTADGKADLEEFYSKHNIDHAFLVSYATGLSDYFLLLEDNVFIAPNFVTHIRSKVTAMKHKPWVLLEFSNRGFLGKFLHSKDLPLLAHFLLLFHKEKPLDRLISHFRALLTQQEPIIFRPFLFYHRVPYEATDDKQKATAFQNRRASGPDNPPGAVFTDMNVFAVHQPWEAYTLDESFFWTYNVSTGKHLTVILNQPANLSRVQVLTGSLVDGKYSLQKGQVELGYNPEGMPQSCTSFVLLGRLLEGQMDQKIILKSMGFEVSCVRLVVKARQVGGLMIRHIYLWKGNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VFQ5</accession>
    <name>A0A8C5VFQ5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WNT3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606542.1">
        <property type="nucleotide sequence ID" value="XM_012751088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VFQ5"/>
    <dbReference type="Ensembl" id="ENSMICT00000029294.2">
        <property type="protein sequence ID" value="ENSMICP00000022149.2"/>
        <property type="gene ID" value="ENSMICG00000038322.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863673"/>
    <dbReference type="KEGG" id="mmur:105863673"/>
    <dbReference type="CTD" id="7473"/>
    <dbReference type="GeneTree" id="ENSGT00940000157854"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009948">
        <property type="term" value="P:anterior/posterior axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009950">
        <property type="term" value="P:dorsal/ventral axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035116">
        <property type="term" value="P:embryonic hindlimb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007276">
        <property type="term" value="P:gamete generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060323">
        <property type="term" value="P:head morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060174">
        <property type="term" value="P:limb bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061180">
        <property type="term" value="P:mammary gland epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904948">
        <property type="term" value="P:midbrain dopaminergic neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048843">
        <property type="term" value="P:negative regulation of axon extension involved in axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048697">
        <property type="term" value="P:positive regulation of collateral sprouting in absence of injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000739">
        <property type="term" value="P:regulation of mesenchymal stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060064">
        <property type="term" value="P:Spemann organizer formation at the anterior end of the primitive streak"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19335">
        <property type="entry name" value="Wnt_Wnt3_Wnt3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000009">
        <property type="entry name" value="Protein Wnt-3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009141">
        <property type="entry name" value="Wnt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF82">
        <property type="entry name" value="PROTO-ONCOGENE WNT-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01843">
        <property type="entry name" value="WNT3PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022149.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="339" mass="37983" checksum="51947249770373F0" modified="2022-01-19" version="1">MLYHCFLSACRSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYALFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VIA6</accession>
    <name>A0A8C5VIA6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 15">Histone deacetylase 1</fullName>
            <shortName evidence="15">HD1</shortName>
            <ecNumber evidence="2 15">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">HDAC1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-(2E)-butenoyl-L-lysyl-[protein] + H2O = (2E)-2-butenoate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:69172"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13707"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:35899"/>
            <dbReference type="ChEBI" id="CHEBI:137954"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:69173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(S)-lactoyl]-L-lysyl-[protein] + H2O = (S)-lactate + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:81387"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:19466"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:231527"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:81388"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[protein] + H2O = L-lysyl-[protein] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58108"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:58109"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 15"/>
    <dbReference type="EMBL" id="ABDC03001597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620859.1">
        <property type="nucleotide sequence ID" value="XM_012765405.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VIA6"/>
    <dbReference type="Ensembl" id="ENSMICT00000027085.2">
        <property type="protein sequence ID" value="ENSMICP00000021177.1"/>
        <property type="gene ID" value="ENSMICG00000030935.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871810"/>
    <dbReference type="KEGG" id="mmur:105871810"/>
    <dbReference type="CTD" id="3065"/>
    <dbReference type="GeneTree" id="ENSGT00940000154301"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160009">
        <property type="term" value="F:histone decrotonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035851">
        <property type="term" value="F:Krueppel-associated box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160216">
        <property type="term" value="F:protein lysine delactylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007492">
        <property type="term" value="P:endoderm development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009913">
        <property type="term" value="P:epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061029">
        <property type="term" value="P:eyelid development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:hair follicle placode formation"/>
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        <property type="term" value="P:hippocampus development"/>
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        <property type="term" value="P:host-mediated suppression of viral transcription"/>
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        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
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        <property type="term" value="P:odontogenesis of dentin-containing tooth"/>
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        <property type="entry name" value="Histone deacetylase"/>
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        <property type="entry name" value="HISTONE DEACETYLASE 1"/>
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        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
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        <property type="entry name" value="HDASUPER"/>
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        <property type="entry name" value="Arginase/deacetylase"/>
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    <keyword evidence="5 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
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        <location>
            <begin position="28"/>
            <end position="318"/>
        </location>
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            <end position="416"/>
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    <sequence length="482" mass="55073" checksum="2B24A92137D24D1B" modified="2022-01-19" version="1">MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACEEEFSDSDEEGEGGRKNSANFKKAKRVKTEDEKEKDPEEKKEVSEEEKTKEEKPEAKGVKEEVKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJ30</accession>
    <name>A0A8C5VJ30_MICMU</name>
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        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RPS5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012758062.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000023975.1"/>
        <property type="gene ID" value="ENSMICG00000016512.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867735"/>
    <dbReference type="KEGG" id="mmur:105867735"/>
    <dbReference type="CTD" id="6193"/>
    <dbReference type="GeneTree" id="ENSGT00390000010806"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
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        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="46"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="22876" checksum="DFE2FD5AAFCFD894" modified="2022-01-19" version="1">MTEWETAAPAVAETPDIKLFGKWSTDDVQINDISLQDYIAVKEKYAKYLPHSAGRYAAKRFRKAQCPIVERLTNSMMMHGRNNGKKLMTVRIVKHAFEIIHLLTGENPLQVLVNAIINSGPREDSTRIGRAGTVRRQAVDVSPLRRVNQAIWLLCTGAREAAFRNIKTIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLI7</accession>
    <name>A0A8C5VLI7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020205">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLI7"/>
    <dbReference type="Ensembl" id="ENSMICT00000036724.2">
        <property type="protein sequence ID" value="ENSMICP00000025435.1"/>
        <property type="gene ID" value="ENSMICG00000036096.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230794"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="126" mass="13052" checksum="9ECB7BC05D9FD3DB" modified="2022-01-19" version="1">METASPGPRKIRINPFSSSSSTFSSRAEGRAGAEGGTFSGSGARLEAPMAVDSLKDQCLPAGSLTSSLEAPAGLFWGLGGLPPRLTRRVSNSLRAWLSCFSSSAILAMDSFSASRSRSVSCGTSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLN3</accession>
    <name>A0A8C5VLN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fumarate hydratase, mitochondrial</fullName>
            <ecNumber evidence="4">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism. Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2).</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:12461"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:12462"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer. Interacts with H2AZ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03007540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000054422.2">
        <property type="protein sequence ID" value="ENSMICP00000025695.1"/>
        <property type="gene ID" value="ENSMICG00000036185.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183122"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="13">
        <location>
            <begin position="412"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024453"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060339"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="467" mass="50456" checksum="F1B54C9E3ED429A2" modified="2022-01-19" version="1">IGTAVPPSWPLNVARMASQNTFWIEYDTFGELKVPNDKYYGVQTVRSTMNFKIGGVTERMPIPVIKAFVNQDYGLDPKIANAMMKAADEVAEGKLNDHFSLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKKPVHPNDHVNKSQSSNDNFPTAMHIAAAVEVHEEMLPGLQKLYDALNAKSKGFAQIIKIGRTHTQDVVPLTLGQEFSGYVQQVSYAMVRIKAAMPRIYELAAGGTAVGTGLNTRIGFAGKVAAKVAALTDLPFVTAPNKFEALAAHDVLIELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNRVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDTSVSFTENCVVERINKLMNEPLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAQQFDEWVKPKDMLGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM57</accession>
    <name>A0A8C5VM57_MICMU</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 2 open reading frame 81</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C2orf81</name>
        <name evidence="2" type="synonym">C4H2orf81</name>
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    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM57"/>
    <dbReference type="Ensembl" id="ENSMICT00000040796.2">
        <property type="protein sequence ID" value="ENSMICP00000025114.2"/>
        <property type="gene ID" value="ENSMICG00000006168.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014979"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028042">
        <property type="entry name" value="DUF4639"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34438:SF1">
        <property type="entry name" value="CHROMOSOME 2 OPEN READING FRAME 81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34438">
        <property type="entry name" value="SI:DKEY-97L20.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15479">
        <property type="entry name" value="DUF4639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="251"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="275"/>
            <end position="303"/>
        </location>
    </feature>
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        <location>
            <begin position="537"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025114.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="592" mass="65389" checksum="FC2BC9E3AF6ACF4D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQ46</accession>
    <name>A0A8C5VQ46_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Tudor domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQ46"/>
    <dbReference type="Ensembl" id="ENSMICT00000046893.2">
        <property type="protein sequence ID" value="ENSMICP00000027827.1"/>
        <property type="gene ID" value="ENSMICG00000031640.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153352"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010304">
        <property type="entry name" value="SMN_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06003">
        <property type="entry name" value="SMN_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="226" mass="25299" checksum="FCC68D11E7BDF60D" modified="2022-01-19" version="1">MSEDLAKQLASYKAQLQQVEAALSGNGENEDWLKLEKDLQEVIELTKDLPSSQPSETLTSSDSFASAQPTHSWKCMAIWSEDGRCYESEVEETDEENGTAALTFAGHGYAEVTPLLSLKPVEGRKAKEDSGNKPMSKKEMMAQQHEYKKRKALKKAQRIKELEQEREDFNNRAYSKNKKGQVKRSIFASPESVTGKAGVGTCAIADKPVTQYQDTSKYNVRHLMSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VR21</accession>
    <name>A0A8C5VR21_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory subunit of type II PKA R-subunit domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RIIAD1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
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                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
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                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
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                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
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                <person name="Raj R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <scope>IDENTIFICATION</scope>
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</entry>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
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    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the eutherian X-chromosome-specific Armcx family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
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        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR000225">
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    </dbReference>
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        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING X-LINKED PROTEIN 4"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="7"/>
            <end position="25"/>
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    </feature>
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        <location>
            <begin position="1989"/>
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        </location>
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        <location>
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</entry>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Blankenburg K."/>
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                <person name="Gnanaolivu R."/>
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                <person name="Hernandez B."/>
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                <person name="Mathew T."/>
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                <person name="Nguyen L."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Larsen P."/>
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                <person name="Hughes D.S."/>
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                <person name="Nguyen L."/>
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                <person name="Puazo M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
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            <authorList>
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    <comment type="function">
        <text evidence="11">Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms homooligomers. Interacts (via C-terminal PDZ domain) with MYO15A; this interaction is necessary for localization of WHRN to stereocilia tips. Interacts (via C-terminal PDZ domain) with MPP1/p55. Interacts with LRRC4C/NGL1. Interacts with MYO7A. Interacts with RPGR. Interacts with EPS8. Interacts with CASK. Interacts with CIB2. Component of USH2 complex, composed of ADGRV1, PDZD7, USH2A and WHRN. Interacts (via PDZ domains) with PDZD7; the interaction is direct. Interacts (via N-terminal PDZ domain) with USH2A (via cytoplasmic region). Interacts with ADGRV1/MASS1 (via cytoplasmic region).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Stereocilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Synapse</location>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012768817.3"/>
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        <property type="protein sequence ID" value="ENSMICP00000026014.1"/>
        <property type="gene ID" value="ENSMICG00000015359.3"/>
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        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:actin filament"/>
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        <property type="term" value="C:ciliary basal body"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:photoreceptor connecting cilium"/>
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        <property type="term" value="C:photoreceptor inner segment"/>
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        <property type="term" value="C:stereocilia ankle link complex"/>
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        <property type="term" value="C:synapse"/>
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    <dbReference type="GO" id="GO:1990696">
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        <property type="term" value="P:cerebellar Purkinje cell layer formation"/>
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        <property type="entry name" value="PDZ"/>
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        <property type="entry name" value="PDZ_sf"/>
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        <property type="entry name" value="USH2_Complex_Protein"/>
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        <property type="entry name" value="Whirlin_HN-like_dom1"/>
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        <property type="entry name" value="PDZ DOMAIN CONTAINING WHIRLIN AND HARMONIN-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR23116:SF37">
        <property type="entry name" value="WHIRLIN"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1009">Hearing</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
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        <location>
            <begin position="140"/>
            <end position="215"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
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            <begin position="521"/>
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    </feature>
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        <location>
            <begin position="628"/>
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        <location>
            <begin position="743"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
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            <begin position="789"/>
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    <sequence length="907" mass="95782" checksum="640D03E7CA1215D8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VVH6</accession>
    <name>A0A8C5VVH6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unc-79 homolog, NALCN channel complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">UNC79</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03003495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000031038.2">
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        <property type="gene ID" value="ENSMICG00000008305.3"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024855">
        <property type="entry name" value="UNC79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21696:SF2">
        <property type="entry name" value="PROTEIN UNC-79 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14776">
        <property type="entry name" value="UNC-79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="932"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1695"/>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
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                <person name="Raveendran M."/>
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                <person name="Chao H."/>
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    <dbReference type="GeneTree" id="ENSGT00500000044966"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903724">
        <property type="term" value="P:positive regulation of centriole elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037693">
        <property type="entry name" value="CCDC15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14817">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14817:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032545.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="999" mass="116539" checksum="A19A7945D5ED06D4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYX8</accession>
    <name>A0A8C5VYX8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/arginine-rich splicing factor 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Delayed-early protein HRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor SRP40</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Splicing factor, arginine/serine-rich 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SRSF5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636630.1">
        <property type="nucleotide sequence ID" value="XM_012781176.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636631.1">
        <property type="nucleotide sequence ID" value="XM_012781177.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636632.1">
        <property type="nucleotide sequence ID" value="XM_012781178.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYX8"/>
    <dbReference type="Ensembl" id="ENSMICT00000049718.2">
        <property type="protein sequence ID" value="ENSMICP00000029929.2"/>
        <property type="gene ID" value="ENSMICG00000037432.2"/>
    </dbReference>
    <dbReference type="CTD" id="6430"/>
    <dbReference type="GeneTree" id="ENSGT00940000158275"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000375">
        <property type="term" value="P:RNA splicing, via transesterification reactions"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12595">
        <property type="entry name" value="RRM1_SRSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12765">
        <property type="entry name" value="RRM2_SRSF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000028">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000138">
        <property type="entry name" value="Serine/arginine-rich splicing factor 5 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF59">
        <property type="entry name" value="SERINE AND ARGININE RICH SPLICING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="4"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="108"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="174"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="181"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00076277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029929.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="269" mass="30933" checksum="0E7913DDA209E844" modified="2022-01-19" version="1">MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRSKSRSVSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZ03</accession>
    <name>A0A8C5VZ03_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PHD finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Polycomb-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PHF1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Polycomblike family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646771.1">
        <property type="nucleotide sequence ID" value="XM_012791317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VZ03"/>
    <dbReference type="Ensembl" id="ENSMICT00000049640.2">
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        <property type="gene ID" value="ENSMICG00000005660.3"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:histone H3K36me3 reader activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:histone H3K4me3 reader activity"/>
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        <property type="term" value="F:histone methyltransferase binding"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
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        <property type="entry name" value="PHD1_PHF1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD2_PHF1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd20449">
        <property type="entry name" value="Tudor_PHF1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD finger protein 1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative PHD finger protein 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative PHD finger protein 1"/>
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        <property type="entry name" value="KDM4-like_Tudor"/>
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        <property type="entry name" value="Mtf2_C_dom"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
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    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF11">
        <property type="entry name" value="PHD FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14061">
        <property type="entry name" value="Mtf2_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF18104">
        <property type="entry name" value="Tudor_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="20">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="335"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="456"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008084"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00068287"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00079981"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033409.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="567" mass="62213" checksum="ED0BAB4C770D8F6B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2J6</accession>
    <name>A0A8C5W2J6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Max-binding protein MNT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Myc antagonist MNT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Protein ROX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MNT</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020372">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2J6"/>
    <dbReference type="Ensembl" id="ENSMICT00000052625.2">
        <property type="protein sequence ID" value="ENSMICP00000030339.2"/>
        <property type="gene ID" value="ENSMICG00000031523.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000048287"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11402">
        <property type="entry name" value="bHLHzip_Mnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000034">
        <property type="entry name" value="MAX network transcriptional repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF99">
        <property type="entry name" value="MAX-BINDING PROTEIN MNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="220"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="319"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="261"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="368"/>
            <end position="381"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00070444"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00075297"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083368"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50888"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030339.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="580" mass="62091" checksum="25AB9A48D656DCA4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W8Z5</accession>
    <name>A0A8C5W8Z5_MICMU</name>
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        <recommendedName>
            <fullName evidence="15">Propionyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC109729720</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <name>biotin</name>
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        </cofactor>
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        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
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    </dbReference>
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        <property type="reaction ID" value="UER00908"/>
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        <property type="component" value="Chromosome 19"/>
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    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ATP_grasp_subdomain_1"/>
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        <property type="entry name" value="BC-like_N"/>
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        <property type="entry name" value="Biotin_carboxylase_complex"/>
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        <property type="entry name" value="Biotin_carboxylation_dom"/>
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    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
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    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR041265">
        <property type="entry name" value="PCC_BT"/>
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    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
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    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
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        <property type="entry name" value="Single_hybrid_motif"/>
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        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
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    </dbReference>
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        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00289">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PreATP-grasp domain"/>
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        <property type="entry name" value="Rudiment single hybrid motif"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
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        <location>
            <begin position="62"/>
            <end position="490"/>
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    </feature>
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            <end position="359"/>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036349.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="73569" checksum="D794AC33BD894612" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAY2</accession>
    <name>A0A8C5WAY2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">NOL12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults. Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with KIAA1191.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597270.1">
        <property type="nucleotide sequence ID" value="XM_012741816.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WAY2"/>
    <dbReference type="Ensembl" id="ENSMICT00000041856.2">
        <property type="protein sequence ID" value="ENSMICP00000036508.1"/>
        <property type="gene ID" value="ENSMICG00000033461.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858580"/>
    <dbReference type="KEGG" id="mmur:105858580"/>
    <dbReference type="CTD" id="79159"/>
    <dbReference type="GeneTree" id="ENSGT00390000015973"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012597270.1"/>
        </source>
    </evidence>
    <sequence length="211" mass="24584" checksum="EAA1592B5629B6EA" modified="2022-01-19" version="1">MGRNKKKRAGDDRRPRLVLSFDEEKRREYLTGFHKRKVERRKAAIEEIKHRLKEEQKKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLPLPEQRDGSEEEASSMEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKLKRKRPQRARDSTKKPPSATRTSKTQRRRLTGKARHSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WB96</accession>
    <name>A0A8C5WB96_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VEZT</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009271">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630746.1">
        <property type="nucleotide sequence ID" value="XM_012775292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WB96"/>
    <dbReference type="Ensembl" id="ENSMICT00000036674.2">
        <property type="protein sequence ID" value="ENSMICP00000036626.1"/>
        <property type="gene ID" value="ENSMICG00000031583.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105877082"/>
    <dbReference type="CTD" id="55591"/>
    <dbReference type="GeneTree" id="ENSGT00390000003290"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="16">
        <location>
            <begin position="150"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="618"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="771"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="780" mass="88953" checksum="927457B1C803F725" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XAW1</accession>
    <name>A0A8C5XAW1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cadherin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Neural cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">CDH2</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="25">Cadherins are calcium-dependent cell adhesion proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells. Required for proper neurite branching. Required for pre- and postsynaptic organization. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homodimer (via extracellular region). Can also form heterodimers with other cadherins (via extracellular region). Dimerization occurs in trans, i.e. with a cadherin chain from another cell. Interacts with CDCP1. Interacts with PCDH8; this complex may also include TAOK2. The interaction with PCDH8 may lead to internalization through TAOK2/p38 MAPK pathway. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. May interact with OBSCN (via protein kinase domain 2). Interacts with FBXO45.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 24">Cell membrane</location>
            <topology evidence="3 24">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592560.1">
        <property type="nucleotide sequence ID" value="XM_012737106.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XAW1"/>
    <dbReference type="Ensembl" id="ENSMICT00000000849.3">
        <property type="protein sequence ID" value="ENSMICP00000000764.3"/>
        <property type="gene ID" value="ENSMICG00000000847.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855871"/>
    <dbReference type="KEGG" id="mmur:105855871"/>
    <dbReference type="CTD" id="1000"/>
    <dbReference type="GeneTree" id="ENSGT00940000155981"/>
    <dbReference type="OrthoDB" id="6079678at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016327">
        <property type="term" value="C:apicolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005916">
        <property type="term" value="C:fascia adherens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044853">
        <property type="term" value="C:plasma membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042383">
        <property type="term" value="C:sarcolemma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045294">
        <property type="term" value="F:alpha-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045295">
        <property type="term" value="F:gamma-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034332">
        <property type="term" value="P:adherens junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048514">
        <property type="term" value="P:blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016339">
        <property type="term" value="P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007043">
        <property type="term" value="P:cell-cell junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090497">
        <property type="term" value="P:mesenchymal cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060563">
        <property type="term" value="P:neuroepithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097118">
        <property type="term" value="P:neuroligin clustering involved in postsynaptic membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000809">
        <property type="term" value="P:positive regulation of synaptic vesicle clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060019">
        <property type="term" value="P:radial glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070445">
        <property type="term" value="P:regulation of oligodendrocyte progenitor proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902897">
        <property type="term" value="P:regulation of postsynaptic density protein 95 clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051146">
        <property type="term" value="P:striated muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097091">
        <property type="term" value="P:synaptic vesicle clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003323">
        <property type="term" value="P:type B pancreatic cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000011">
        <property type="entry name" value="Cadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000019">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000022">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000027">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000045">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000001">
        <property type="entry name" value="Cadherin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000139">
        <property type="entry name" value="Cadherin-2 preproprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039808">
        <property type="entry name" value="Cadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014868">
        <property type="entry name" value="Cadherin_pro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000233">
        <property type="entry name" value="Cadherin_Y-type_LIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027:SF79">
        <property type="entry name" value="CADHERIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24027">
        <property type="entry name" value="CADHERIN-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01049">
        <property type="entry name" value="CADH_Y-type_LIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08758">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01820">
        <property type="entry name" value="DESMOCOLLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01055">
        <property type="entry name" value="Cadherin_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="5"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0165">Cleavage on pair of basic residues</keyword>
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        <location>
            <begin position="1"/>
            <end position="25"/>
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            <end position="906"/>
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            <begin position="160"/>
            <end position="267"/>
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            <begin position="268"/>
            <end position="382"/>
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            <begin position="383"/>
            <end position="497"/>
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            <begin position="498"/>
            <end position="605"/>
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        <location>
            <begin position="604"/>
            <end position="710"/>
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            <begin position="863"/>
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            <begin position="863"/>
            <end position="880"/>
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    <evidence type="ECO:0000256" key="26">
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        <source>
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    <evidence type="ECO:0000256" key="28">
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        <source>
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    <sequence length="906" mass="99789" checksum="9644AD16831B32E8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XB05</accession>
    <name>A0A8C5XB05_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Bromodomain adjacent to zinc finger domain 2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">BAZ2A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WAL family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000001080.3">
        <property type="protein sequence ID" value="ENSMICP00000000984.3"/>
        <property type="gene ID" value="ENSMICG00000001077.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159490"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033553">
        <property type="term" value="C:rDNA heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05503">
        <property type="entry name" value="Bromo_BAZ2A_B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15629">
        <property type="entry name" value="PHD_BAZ2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000023">
        <property type="entry name" value="Bromodomain adjacent to zinc finger domain protein 2B"/>
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    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037374">
        <property type="entry name" value="BAZ2A/B_Bromo"/>
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        <property type="entry name" value="Bromodomain"/>
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        <property type="entry name" value="Bromodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028940">
        <property type="entry name" value="PHD_BAZ2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
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    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915:SF5">
        <property type="entry name" value="BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45915">
        <property type="entry name" value="TRANSCRIPTION INTERMEDIARY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
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        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
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        <property type="entry name" value="ZF_PHD_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DDT" evidence="16">
        <location>
            <begin position="820"/>
            <end position="885"/>
        </location>
    </feature>
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        <location>
            <begin position="1632"/>
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    </feature>
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            <begin position="1765"/>
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    </feature>
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            <begin position="1"/>
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            <begin position="1013"/>
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            <begin position="1127"/>
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    <feature type="region of interest" description="Disordered" evidence="13">
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            <begin position="1252"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1690"/>
            <end position="1744"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="36"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
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            <begin position="132"/>
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    </feature>
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        <location>
            <begin position="628"/>
            <end position="640"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="641"/>
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            <begin position="668"/>
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        <location>
            <begin position="711"/>
            <end position="720"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="728"/>
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    </feature>
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        <location>
            <begin position="1023"/>
            <end position="1033"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
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        <location>
            <begin position="1186"/>
            <end position="1214"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1252"/>
            <end position="1265"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1278"/>
            <end position="1287"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1317"/>
            <end position="1331"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1694"/>
            <end position="1703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00007444"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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        <source>
            <dbReference type="PROSITE" id="PS50827"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000984.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1860" mass="206039" checksum="E35E3E4EAA8CB06A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDN8</accession>
    <name>A0A8C5XDN8_MICMU</name>
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        <recommendedName>
            <fullName evidence="10">Homeobox protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOXC9</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the Abd-B homeobox family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012619640.1">
        <property type="nucleotide sequence ID" value="XM_012764186.3"/>
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    <dbReference type="SMR" id="A0A8C5XDN8"/>
    <dbReference type="Ensembl" id="ENSMICT00000011708.3">
        <property type="protein sequence ID" value="ENSMICP00000010657.1"/>
        <property type="gene ID" value="ENSMICG00000011714.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871057"/>
    <dbReference type="KEGG" id="mmur:105871057"/>
    <dbReference type="CTD" id="3225"/>
    <dbReference type="GeneTree" id="ENSGT00940000160866"/>
    <dbReference type="OMA" id="GYADYMY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:proximal/distal pattern formation"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006711">
        <property type="entry name" value="Hox9_activation_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017112">
        <property type="entry name" value="HXA9/HXB9/HXC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45970">
        <property type="entry name" value="AGAP004664-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45970:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-C9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04617">
        <property type="entry name" value="Hox9_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037109">
        <property type="entry name" value="Homeobox_Hox9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00003263"/>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="260" mass="29234" checksum="0A978FF948F5BCAE" modified="2022-01-19" version="1">MSATGPISNYYVDSLISHDNEDLLASRFPATGAHPAAARPSGLVPDCSDFPSCSFAPKPAVFSTSWAPVPSQSSVVYHPYGPQPHLGADTRYMRTWLEPLSGAVSFPSFPAGGRHYALKPDAYPGRRADCGPGDGRSYPDYMYGSPGELRDRAPQTLPSPEADALAGSKHKEEKADLDPSNPVANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARVLNLTERQVKIWFQNRRMKMKKMNKEKTDKEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XFU1</accession>
    <name>A0A8C5XFU1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPD52 like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TPD52L3</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPD52 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XFU1"/>
    <dbReference type="Ensembl" id="ENSMICT00000033679.2">
        <property type="protein sequence ID" value="ENSMICP00000018098.2"/>
        <property type="gene ID" value="ENSMICG00000000600.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163110"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007327">
        <property type="entry name" value="TPD52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307">
        <property type="entry name" value="TUMOR PROTEIN D52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19307:SF5">
        <property type="entry name" value="TUMOR PROTEIN D55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04201">
        <property type="entry name" value="TPD52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018098.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="135" mass="15282" checksum="5E5E4F35E1D02B8A" modified="2022-01-19" version="1">MPDPMTKTSVGTYESHPTSEPMALTEAEQLELKSELAKLEAEIVTLRQALAAKERRCGELKRKLGLTTMDGLRQNLSKSWHDVQVSNTYVKQKTSVALSSMSSAICRKFGDMKKSATFRSFEEQMFNKYSLNQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGB6</accession>
    <name>A0A8C5XGB6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Serine/threonine-protein kinase N1</fullName>
            <ecNumber evidence="7">2.7.11.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Protein kinase C-like 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Protein kinase C-like PKN</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Protein-kinase C-related kinase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Serine-threonine protein kinase N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="36" type="primary">PKN1</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="36" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="36" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03027736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613768.1">
        <property type="nucleotide sequence ID" value="XM_012758314.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XGB6"/>
    <dbReference type="Ensembl" id="ENSMICT00000048801.2">
        <property type="protein sequence ID" value="ENSMICP00000019498.2"/>
        <property type="gene ID" value="ENSMICG00000035009.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105867909"/>
    <dbReference type="CTD" id="5585"/>
    <dbReference type="GeneTree" id="ENSGT00940000154990"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010631">
        <property type="term" value="P:epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08687">
        <property type="entry name" value="C2_PKN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11630">
        <property type="entry name" value="HR1_PKN1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11622">
        <property type="entry name" value="HR1_PKN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05589">
        <property type="entry name" value="STKc_PKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000001">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000002">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000003">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000058">
        <property type="entry name" value="Putative serine/threonine-protein kinase N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000038">
        <property type="entry name" value="serine/threonine-protein kinase N2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037784">
        <property type="entry name" value="C2_PKN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037317">
        <property type="entry name" value="PKN1_HR1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037313">
        <property type="entry name" value="PKN_HR1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17 28 30" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="19" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="REM-1" evidence="35">
        <location>
            <begin position="31"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="35">
        <location>
            <begin position="118"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="35">
        <location>
            <begin position="205"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="32">
        <location>
            <begin position="313"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="33">
        <location>
            <begin position="622"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="34">
        <location>
            <begin position="882"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="565"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="30">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="29">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00072336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00075876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00077669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00079335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00080562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019498.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="949" mass="104637" checksum="9AD152FED25E0D18" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJ87</accession>
    <name>A0A8C5XJ87_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PI3K/PI4K catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJ87"/>
    <dbReference type="Ensembl" id="ENSMICT00000040212.2">
        <property type="protein sequence ID" value="ENSMICP00000027951.1"/>
        <property type="gene ID" value="ENSMICG00000031659.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074892"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="184" mass="21017" checksum="D6109536E30479A6" modified="2022-01-19" version="1">MIEPVVNAMSIYQVKKQSQLSLIDYFRQEHGSYTTEAFLSAQCNFVQSCTGYCLVCYLLQVKDRHNGNILLDAECHIIHIDFGFILSSSPRNLGFETSADHRVCGCNGWPRWEKVVQIVEIMQQGSQLPCFHGSSTICDLKERFHMSITEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJS5</accession>
    <name>A0A8C5XJS5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sulfiredoxin</fullName>
            <ecNumber evidence="10">1.8.98.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SRXN1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17545"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="Rhea" id="RHEA-COMP:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:17976"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:61973"/>
            <dbReference type="ChEBI" id="CHEBI:61974"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.8.98.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the sulfiredoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.8.98.2" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03021655">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610689.1">
        <property type="nucleotide sequence ID" value="XM_012755235.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJS5"/>
    <dbReference type="Ensembl" id="ENSMICT00000041861.2">
        <property type="protein sequence ID" value="ENSMICP00000029834.1"/>
        <property type="gene ID" value="ENSMICG00000038174.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105866069"/>
    <dbReference type="KEGG" id="mmur:105866069"/>
    <dbReference type="CTD" id="140809"/>
    <dbReference type="GeneTree" id="ENSGT00390000007832"/>
    <dbReference type="OrthoDB" id="10023328at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032542">
        <property type="term" value="F:sulfiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16395">
        <property type="entry name" value="Srx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1530.10:FF:000001">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1530.10">
        <property type="entry name" value="Conserved hypothetical protein from pyrococcus furiosus pfu- 392566-001, ParB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016692">
        <property type="entry name" value="Sulfiredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21348:SF2">
        <property type="entry name" value="SULFIREDOXIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017267">
        <property type="entry name" value="Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="ParB/Sulfiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB-like N-terminal" evidence="14">
        <location>
            <begin position="42"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="98"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017267-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="137" mass="14242" checksum="277B65BF3B33F774" modified="2022-01-19" version="1">MGLRAGGALGRAGAGRGAPEGPGPSGGAHNGSIHSGCIAAVHNVPLSVLIRPLPSVLDPAKVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XKD0</accession>
    <name>A0A8C5XKD0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tumor protein p73</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TP73</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Found in a complex with p53/TP53 and CABLES1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the p53 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002049">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002050">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XKD0"/>
    <dbReference type="Ensembl" id="ENSMICT00000033635.2">
        <property type="protein sequence ID" value="ENSMICP00000031305.2"/>
        <property type="gene ID" value="ENSMICG00000037331.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183153"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097371">
        <property type="term" value="F:MDM2/MDM4 family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033326">
        <property type="term" value="P:cerebrospinal fluid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021766">
        <property type="term" value="P:hippocampus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042771">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060044">
        <property type="term" value="P:negative regulation of cardiac muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045793">
        <property type="term" value="P:positive regulation of cell size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902167">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901248">
        <property type="term" value="P:positive regulation of lung ciliated cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08367">
        <property type="entry name" value="P53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09571">
        <property type="entry name" value="SAM_tumor-p73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.720:FF:000002">
        <property type="entry name" value="Cellular tumor antigen p53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000020">
        <property type="entry name" value="Tumor protein 63 (p63)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012346">
        <property type="entry name" value="p53/RUNT-type_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057064">
        <property type="entry name" value="P53_central_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011615">
        <property type="entry name" value="p53_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010991">
        <property type="entry name" value="p53_tetrameristn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002117">
        <property type="entry name" value="p53_tumour_suppressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037612">
        <property type="entry name" value="Tumour-p73_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11447">
        <property type="entry name" value="CELLULAR TUMOR ANTIGEN P53"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
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                <person name="Khan Z."/>
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                <person name="Lee S."/>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Bandaranaike D."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with C6orf89.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611805.1">
        <property type="nucleotide sequence ID" value="XM_012756351.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSY6"/>
    <dbReference type="Ensembl" id="ENSMICT00000070541.1">
        <property type="protein sequence ID" value="ENSMICP00000041030.1"/>
        <property type="gene ID" value="ENSMICG00000047770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866771"/>
    <dbReference type="KEGG" id="mmur:105866771"/>
    <dbReference type="CTD" id="680"/>
    <dbReference type="GeneTree" id="ENSGT01150000286942"/>
    <dbReference type="OrthoDB" id="10049706at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004946">
        <property type="term" value="F:bombesin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000166">
        <property type="entry name" value="Bombesin receptor subtype-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001560">
        <property type="entry name" value="Bombesin_rcpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001556">
        <property type="entry name" value="Bombsn_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF6">
        <property type="entry name" value="BOMBESIN RECEPTOR SUBTYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00637">
        <property type="entry name" value="BOMBESIN3R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00358">
        <property type="entry name" value="BOMBESINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="11 15" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="64"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="399" mass="44219" checksum="F3266670B2E2BD16" modified="2022-01-19" version="1">MSQRQPHSPNETLISITNDTESSSSVVSNDTTNKGQTGNNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAKGWLFGRIGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGCIWIVSMIFALPEAIFSNVYTFRDPEKNTTFESCTSYPVSEKLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFAVCWLPNHLLYLYHSFTYQTYVDPSAVHFVVTILSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCCKAEMPEPPSADTPLNNLAVMGRVPGAGSTQVSDISVTLFTGCSVKKEEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVD8</accession>
    <name>A0A8C5XVD8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">High mobility group nucleosome-binding domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XVD8"/>
    <dbReference type="Ensembl" id="ENSMICT00000065109.1">
        <property type="protein sequence ID" value="ENSMICP00000042016.1"/>
        <property type="gene ID" value="ENSMICG00000044932.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182802"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000079">
        <property type="entry name" value="HMGN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087:SF12">
        <property type="entry name" value="NON-HISTONE CHROMOSOMAL PROTEIN HMG-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087">
        <property type="entry name" value="NONHISTONE CHROMOSOMAL PROTEIN HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01101">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00925">
        <property type="entry name" value="NONHISHMG17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00527">
        <property type="entry name" value="HMG17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00355">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13587" checksum="80AEAD761A55FC63" modified="2022-01-19" version="1">MPNRKVSLAKGTVKEEPKRRSARLSAKPAPAKVETKPIKAACNQKGKRGAKAEVVNQETKDLPAENGETKTEESPASDETGEKEAKSDSYHTPCLISGPCLPCTIQRNIFINYFVNASFLVALET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYC2</accession>
    <name>A0A8C5XYC2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Splicing factor 45</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA-binding motif protein 17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105860686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds SXL. Associates with the spliceosome. Interacts with SF3B1, SF1 and U2AF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03013144">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYC2"/>
    <dbReference type="Ensembl" id="ENSMICT00000063413.1">
        <property type="protein sequence ID" value="ENSMICP00000043359.1"/>
        <property type="gene ID" value="ENSMICG00000041489.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00790000123099"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12647">
        <property type="entry name" value="RRM_UHM_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000079">
        <property type="entry name" value="Putative splicing factor 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034653">
        <property type="entry name" value="SPF45_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031066">
        <property type="entry name" value="Splicing_factor_SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="313"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00065586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR031066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="409" mass="45442" checksum="AEF130B83AFD5746" modified="2022-01-19" version="1">MSLYDDLGVEASDSKTEGWSKNFKLLQSQLQVKKAALTQAESQRTKQSTVVLAPVTDLKRGGSSDDRQLVDSPPHVAAGLKGPVPSGFSAGEVLVPLAGEYDPMFPNDCEEVVKRQREERQRRRELERQKEIEEREKRRKDRHEGSGFSRRPDPDSDEDEDYERERRKRSMRGAAIAPPTGLVERDKELPRDFPYEEDSRPRSQSSKAAIPPPSDEERDRPRSPTGPSNSFLANMGGTVALKIMQKYGFREGQGLGKHEQGLSTALSVEKTSKRGGKITVGDATERGDSPGKCDATKKSDSNPLTEILKCPTNVVLLRNMVGAGEVDEDLEVETKEECEKYGKVGKCVIFEIPGAPEDEAGQIFLEFEKVESVMKAVVDLNGREIGGRVVKACFYNLDKFRVLDLAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZN1</accession>
    <name>A0A8C5XZN1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GNGT2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136647.1">
        <property type="nucleotide sequence ID" value="XM_020281058.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136648.1">
        <property type="nucleotide sequence ID" value="XM_020281059.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136650.1">
        <property type="nucleotide sequence ID" value="XM_020281061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZN1"/>
    <dbReference type="Ensembl" id="ENSMICT00000061332.1">
        <property type="protein sequence ID" value="ENSMICP00000043703.1"/>
        <property type="gene ID" value="ENSMICG00000045728.1"/>
    </dbReference>
    <dbReference type="GeneID" id="109729475"/>
    <dbReference type="KEGG" id="mmur:109729475"/>
    <dbReference type="CTD" id="2793"/>
    <dbReference type="GeneTree" id="ENSGT01100000263525"/>
    <dbReference type="OMA" id="SWLEIAW"/>
    <dbReference type="OrthoDB" id="9933679at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="53"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
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                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZQ0"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="30" mass="3598" checksum="166E026A94516FE4" modified="2022-01-19" version="1">FFSRCSRILLSSLRLSISRLLTLSRRCWQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y604</accession>
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        <recommendedName>
            <fullName evidence="6">Ornithine decarboxylase antizyme 2</fullName>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ODC antizyme family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000043120.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157725"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:viral translational frameshifting"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ornithine decarboxylase antizyme 1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
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        <property type="entry name" value="ODC_AZ_sf"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
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            <dbReference type="Ensembl" id="ENSMICP00000046029.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="167" mass="18782" checksum="1BBE54B3C894C8C2" modified="2022-01-19" version="1">MINTQDTSTRYSILPLSNCLQYIIPGPLWAGRDPSLSALIYEDKKLPVTQDLPVNDGKPHIVHLQNEATEVNVSSWDAVLSSQSLFIESPDGLLADGNEGLLALLEFAEEKMKVNYIFICFRKGWEDRGPLLKTFSFLGFEIMHPGHPCVPSWPDVMFMDQNLSNED</sequence>
</entry>
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            <fullName evidence="16">Histone H2A</fullName>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
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            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the histone H2A family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012742060.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000047412.1"/>
        <property type="gene ID" value="ENSMICG00000047655.1"/>
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    <dbReference type="GeneID" id="105858728"/>
    <dbReference type="KEGG" id="mmur:105858728"/>
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        <property type="component" value="Chromosome 14"/>
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    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:structural constituent of chromatin"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000103">
        <property type="entry name" value="Histone H2A type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="H2A/H2B/H3"/>
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    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
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    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
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    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0164">Citrullination</keyword>
    <keyword evidence="12 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="14 16" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="18">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="19">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="130" mass="14112" checksum="A8C8539793FCB259" modified="2022-01-19" version="1">MSGRGKQGGKTRAKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHQKAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8K0</accession>
    <name>A0A8C5Y8K0_MICMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03015630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y8K0"/>
    <dbReference type="Ensembl" id="ENSMICT00000066696.1">
        <property type="protein sequence ID" value="ENSMICP00000047027.1"/>
        <property type="gene ID" value="ENSMICG00000044121.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000235027"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="56" mass="7091" checksum="AEBFA6BD9C7ACB32" modified="2025-10-08" version="2">MIEDNDFLEVNVREEIEEFFPRMWKINQDKRRLMKSIKDQKIKIEWGKKLNRRLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAQ4</accession>
    <name>A0A8C5YAQ4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="27">Solute carrier family 22 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">SLC22A1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-adrenaline(out) = (R)-adrenaline(in)</text>
            <dbReference type="Rhea" id="RHEA:73875"/>
            <dbReference type="ChEBI" id="CHEBI:71406"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(R)-salsolinol(in) = (R)-salsolinol(out)</text>
            <dbReference type="Rhea" id="RHEA:74791"/>
            <dbReference type="ChEBI" id="CHEBI:194082"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-methylnicotinamide(out) = 1-methylnicotinamide(in)</text>
            <dbReference type="Rhea" id="RHEA:73859"/>
            <dbReference type="ChEBI" id="CHEBI:16797"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidyl-L-proline diketopiperazine(in) = L-histidyl-L-proline diketopiperazine(out)</text>
            <dbReference type="Rhea" id="RHEA:74787"/>
            <dbReference type="ChEBI" id="CHEBI:90039"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetylcholine(in) = acetylcholine(out)</text>
            <dbReference type="Rhea" id="RHEA:74663"/>
            <dbReference type="ChEBI" id="CHEBI:15355"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>dopamine(out) = dopamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73863"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>guanidine(out) = guanidine(in)</text>
            <dbReference type="Rhea" id="RHEA:73883"/>
            <dbReference type="ChEBI" id="CHEBI:30087"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>histamine(out) = histamine(in)</text>
            <dbReference type="Rhea" id="RHEA:73879"/>
            <dbReference type="ChEBI" id="CHEBI:58432"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>prostaglandin E2(out) = prostaglandin E2(in)</text>
            <dbReference type="Rhea" id="RHEA:50984"/>
            <dbReference type="ChEBI" id="CHEBI:606564"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>prostaglandin F2alpha(out) = prostaglandin F2alpha(in)</text>
            <dbReference type="Rhea" id="RHEA:50988"/>
            <dbReference type="ChEBI" id="CHEBI:57404"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>putrescine(out) = putrescine(in)</text>
            <dbReference type="Rhea" id="RHEA:72135"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>serotonin(out) = serotonin(in)</text>
            <dbReference type="Rhea" id="RHEA:73867"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>spermidine(in) = spermidine(out)</text>
            <dbReference type="Rhea" id="RHEA:35039"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>thiamine(in) = thiamine(out)</text>
            <dbReference type="Rhea" id="RHEA:34919"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Basal cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008671">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615075.1">
        <property type="nucleotide sequence ID" value="XM_012759621.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAQ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000061056.1">
        <property type="protein sequence ID" value="ENSMICP00000047818.1"/>
        <property type="gene ID" value="ENSMICG00000007625.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868589"/>
    <dbReference type="KEGG" id="mmur:105868589"/>
    <dbReference type="GeneTree" id="ENSGT00940000162065"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016328">
        <property type="term" value="C:lateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901235">
        <property type="term" value="F:(R)-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005277">
        <property type="term" value="F:acetylcholine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008504">
        <property type="term" value="F:monoamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008514">
        <property type="term" value="F:organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015132">
        <property type="term" value="F:prostaglandin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015214">
        <property type="term" value="F:pyrimidine nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015234">
        <property type="term" value="F:thiamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019534">
        <property type="term" value="F:toxin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015870">
        <property type="term" value="P:acetylcholine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990748">
        <property type="term" value="P:cellular detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090494">
        <property type="term" value="P:dopamine uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048241">
        <property type="term" value="P:epinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015874">
        <property type="term" value="P:norepinephrine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902616">
        <property type="term" value="P:O-acyl-L-carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072530">
        <property type="term" value="P:purine-containing compound transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051610">
        <property type="term" value="P:serotonin uptake"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000148">
        <property type="entry name" value="Solute carrier family 22 member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00898">
        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="379"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="100"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00035901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00037001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="554" mass="60985" checksum="897CAFF3E100CFBD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAY1</accession>
    <name>A0A8C5YAY1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="ABDC03009832">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAY1"/>
    <dbReference type="Ensembl" id="ENSMICT00000070114.1">
        <property type="protein sequence ID" value="ENSMICP00000048650.1"/>
        <property type="gene ID" value="ENSMICG00000045041.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154514"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043368">
        <property type="entry name" value="FKBP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46493:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="2">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="159" mass="18204" checksum="F77364BD1A991B7E" modified="2022-01-19" version="1">FLTVNKDHLVTAYNHLFETKHFKGIESVSKVSEQVKHVKLNENKPKETKSEETLDEGPLKYMKSVLKKGDKTNFPQKGDVVHCWYIGTLQDGTVFDTYIQTSSKKKKNSNPLSFKVEVGKVIRGWDEIEPQWVYGKRGQPDAKIPPNAKLVKMELVDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YD16</accession>
    <name>A0A8C5YD16_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucuronosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03029051">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YD16"/>
    <dbReference type="Ensembl" id="ENSMICT00000058156.1">
        <property type="protein sequence ID" value="ENSMICP00000049592.1"/>
        <property type="gene ID" value="ENSMICG00000012671.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163930"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000322">
        <property type="entry name" value="UDP glucuronosyltransferase family 2 member B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000081">
        <property type="entry name" value="UDP-glucuronosyltransferase 2A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF12">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE 2B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034701987" description="glucuronosyltransferase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="370" mass="42692" checksum="B74476F373E3CC7B" modified="2022-01-19" version="1">MTQQWTSVLLLMQLSVYFSSGTCGKVLVWPTEYSHWMNMKTILDELVQRGHEVTVLASSASIVIDPSKTSAIKFEVYPTSLSKEEFDGVFIHLFHRAIYDVPKDTFWSHVSLIEEMKYEFTEIMRKLCKDAALNKKLMTKLQVSKFDVVLAGGIGFRADLLAEILKTPLVCSLHCSPGYTFEKHSGGLLFPPSYIPVVMSEFSDRMTFMERVKNMIHVLYYDFWFQAYDMKEWNQLYLEILGRPTTLYETMRKADMWLIRTYWDFEFPRPLLPNFDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVFSLGSMLSNMTEERANVIASALAQIPQKVLWRFDGKKPDTFGPNTRLYKWLPQNDLLGNKSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEE9</accession>
    <name>A0A8C5YEE9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tox-GHH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018894">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEE9"/>
    <dbReference type="Ensembl" id="ENSMICT00000064025.1">
        <property type="protein sequence ID" value="ENSMICP00000049488.1"/>
        <property type="gene ID" value="ENSMICG00000042810.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234566"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048666">
        <property type="term" value="P:neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.180.10.10:FF:000012">
        <property type="entry name" value="Teneurin transmembrane protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056823">
        <property type="entry name" value="TEN-like_YD-shell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051216">
        <property type="entry name" value="Teneurin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028916">
        <property type="entry name" value="Tox-GHH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219">
        <property type="entry name" value="TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11219:SF65">
        <property type="entry name" value="TENEURIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25023">
        <property type="entry name" value="TEN_YD-shell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23538">
        <property type="entry name" value="Teneurin_ABD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15636">
        <property type="entry name" value="Tox-GHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Teneurin-like YD-shell" evidence="5">
        <location>
            <begin position="4"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Tox-GHH" evidence="4">
        <location>
            <begin position="517"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="68926" checksum="BD84103B0CA0D215" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YG15</accession>
    <name>A0A8C5YG15_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 17">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="17">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YG15"/>
    <dbReference type="Ensembl" id="ENSMICT00000072380.1">
        <property type="protein sequence ID" value="ENSMICP00000051157.1"/>
        <property type="gene ID" value="ENSMICG00000049081.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009405"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000008">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="105" mass="11613" checksum="619AF341066D1C03" modified="2022-01-19" version="1">MGDVEKGKKIFVHKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERANLIAYLKKATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGC8</accession>
    <name>A0A8C5YGC8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC19</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03001060">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGC8"/>
    <dbReference type="Ensembl" id="ENSMICT00000073068.1">
        <property type="protein sequence ID" value="ENSMICP00000051301.1"/>
        <property type="gene ID" value="ENSMICG00000049177.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161784"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097356">
        <property type="term" value="C:perinucleolar compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905337">
        <property type="term" value="P:positive regulation of aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071211">
        <property type="term" value="P:protein targeting to vacuole involved in autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF326">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="110"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="310" mass="35022" checksum="176F380545FB2225" modified="2022-01-19" version="1">MPLLNDAMPLMKEPRPPPQLPLPWVLPSLFAAFNVVLLVVFSALFFAFPCRWLAQNGEWVFPIVTGPLFVLTFFSLVSLNFSDPGILHQGSAEQGPMMVHVVWVNHRAFRLQWCPKCCFHRPPRTYHCPWCNVCVEDFDHHCKWVNNCIGHRNFRFFMLLVLSLCLYLSALLVTCLIFLVRTTHLPFSTDKVIAVTVAVPAAGFLVPLFLLLLIQAMSVSAAERSCEGKRRYLHGYNPFDQGCASNWYLTICAPLGPKYMAEAVQLQRVVGSDWVPMPSLHSPTCPFAFEPPAPPSGSVQAREGPPREWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YI22</accession>
    <name>A0A8C5YI22_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Sigma non-opioid intracellular receptor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Sigma 1-type opioid receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SIGMAR1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ERG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625558.1">
        <property type="nucleotide sequence ID" value="XM_012770104.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YI22"/>
    <dbReference type="Ensembl" id="ENSMICT00000059858.1">
        <property type="protein sequence ID" value="ENSMICP00000050525.1"/>
        <property type="gene ID" value="ENSMICG00000042605.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105874342"/>
    <dbReference type="KEGG" id="mmur:105874342"/>
    <dbReference type="CTD" id="10280"/>
    <dbReference type="GeneTree" id="ENSGT00390000012082"/>
    <dbReference type="OMA" id="AMYVIHA"/>
    <dbReference type="OrthoDB" id="347124at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="223" mass="25042" checksum="3772847F9D7F0B81" modified="2022-01-19" version="1">MQWAVGRRWAWAALLLAAAAVLAQVVWLWLGTQSFVFQQEEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EE10</accession>
    <name>A0A8C6EE10_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Intraflagellar transport 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC105875560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03009224">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628114.1">
        <property type="nucleotide sequence ID" value="XM_012772660.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EE10"/>
    <dbReference type="Ensembl" id="ENSMICT00000052025.2">
        <property type="protein sequence ID" value="ENSMICP00000039544.1"/>
        <property type="gene ID" value="ENSMICG00000035436.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875560"/>
    <dbReference type="KEGG" id="mmur:105875560"/>
    <dbReference type="GeneTree" id="ENSGT00390000007109"/>
    <dbReference type="OrthoDB" id="444379at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000012">
        <property type="entry name" value="intraflagellar transport protein 74 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029602">
        <property type="entry name" value="IFT74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31432:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 74 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="69531" checksum="6CA7B4773A3D0C7A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EEE4</accession>
    <name>A0A8C6EEE4_MICMU</name>
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        <recommendedName>
            <fullName evidence="5">Ceramide transfer protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Collagen type IV alpha-3-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">START domain-containing protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">StAR-related lipid transfer protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CERT1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-hexadecanoylsphing-4-enine(in) = N-hexadecanoylsphing-4-enine(out)</text>
            <dbReference type="Rhea" id="RHEA:45720"/>
            <dbReference type="ChEBI" id="CHEBI:72959"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03016572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C6EEE4"/>
    <dbReference type="Ensembl" id="ENSMICT00000038057.2">
        <property type="protein sequence ID" value="ENSMICP00000039832.1"/>
        <property type="gene ID" value="ENSMICG00000028951.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155123"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13283">
        <property type="entry name" value="PH_GPBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08872">
        <property type="entry name" value="START_STARD11-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000104">
        <property type="entry name" value="collagen type IV alpha-3-binding protein-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000003">
        <property type="entry name" value="Collagen type IV alpha-3-binding protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041952">
        <property type="entry name" value="STARD11_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF53">
        <property type="entry name" value="CERAMIDE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
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        <location>
            <begin position="389"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
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        <location>
            <begin position="270"/>
            <end position="297"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000074"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045146"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080074"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039832.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKF0</accession>
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        <submittedName>
            <fullName evidence="4">Ankyrin repeat and BTB domain containing 1</fullName>
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        <name evidence="4" type="primary">ABTB1</name>
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        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
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            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03025608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025610">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025611">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025612">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025613">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025614">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKF0"/>
    <dbReference type="Ensembl" id="ENSMICT00000070738.1">
        <property type="protein sequence ID" value="ENSMICP00000049011.1"/>
        <property type="gene ID" value="ENSMICG00000031555.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017131"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18296">
        <property type="entry name" value="BTB2_POZ_ABTB1_BPOZ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000064">
        <property type="entry name" value="Ankyrin repeat and BTB/POZ domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044515">
        <property type="entry name" value="ABTB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB/POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46231:SF1">
        <property type="entry name" value="ANKYRIN REPEAT AND BTB_POZ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="264"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="465" mass="52037" checksum="B2BD44566634414B" modified="2022-01-19" version="1">MDTSDLFSSCRKGDVGRVRYLLEQRDVEVNVRDKWDSTPFPPPLSPVVAGARCEANTFDGERCLYGALSDAIRRALRDYKQVTSSCGRRDCFRDFLQRLLEQGLHSDIAFQVHGRRLRAHRCVLGARSDYLARALGTRWRDKGVVVLRHPLVRPRHLPFSLCRLPPPTPGWSECQGESRLAKQCHLWDLLGDLEAKREKVSEFVASKPGTCVKAVTIEPAPGDPRLRRDFARLAERALPAELRGDLWELPFPCPDDSDSFPSRPDVCFRVGNCAFPCHKAFFCGRSDYFRALLDGHFRETEEEPGTSGDPQTVALSGVSPETFAHVLRYVYSDHTELPPEAAYDVLGAADMYLLPGLKRLCGRSLAQLLHEDTVVGVWRVAKLFHLARLEDQCAQFMAKVLDKVRPAVREEAAAVASRQETDSIPLVDDIRFHVAAAAQTHSAAADAQRRLRALQDLLVALGLDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EL03</accession>
    <name>A0A8C6EL03_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Diacylglycerol kinase</fullName>
            <shortName evidence="24">DAG kinase</shortName>
            <ecNumber evidence="24">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DGKI</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="22">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 24">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="24"/>
    <dbReference type="EMBL" id="ABDC03015190">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015191">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015192">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015193">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015194">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EL03"/>
    <dbReference type="Ensembl" id="ENSMICT00000066706.1">
        <property type="protein sequence ID" value="ENSMICP00000050247.1"/>
        <property type="gene ID" value="ENSMICG00000003946.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158094"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005095">
        <property type="term" value="F:GTPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060079">
        <property type="term" value="P:excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046959">
        <property type="term" value="P:habituation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007269">
        <property type="term" value="P:neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046579">
        <property type="term" value="P:positive regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099171">
        <property type="term" value="P:presynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900452">
        <property type="term" value="P:regulation of long-term synaptic depression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051966">
        <property type="term" value="P:regulation of synaptic transmission, glutamatergic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20850">
        <property type="entry name" value="C1_DGKiota_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20896">
        <property type="entry name" value="C1_DGKiota_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000061">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047486">
        <property type="entry name" value="C1_DGKiota_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047487">
        <property type="entry name" value="C1_DGKiota_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056383">
        <property type="entry name" value="DGKI-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF92">
        <property type="entry name" value="DIACYLGLYCEROL KINASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23578">
        <property type="entry name" value="DGKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 23" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="13 24" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 24" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="26">
        <location>
            <begin position="365"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="23">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="23">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="323"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="25">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1071" mass="118129" checksum="AB66901391E4B6E5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6ELS3</accession>
    <name>A0A8C6ELS3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">SCN10A</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others. Interacts with NEDD4 and NEDD4L.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000469">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000072522.1">
        <property type="protein sequence ID" value="ENSMICP00000051160.1"/>
        <property type="gene ID" value="ENSMICG00000048891.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154992"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001518">
        <property type="term" value="C:voltage-gated sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086006">
        <property type="term" value="F:voltage-gated sodium channel activity involved in cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086016">
        <property type="term" value="P:AV node cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086043">
        <property type="term" value="P:bundle of His cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060371">
        <property type="term" value="P:regulation of atrial cardiac muscle cell membrane depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055117">
        <property type="term" value="P:regulation of cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13433">
        <property type="entry name" value="Na_channel_gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000001">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000002">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000004">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000049">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000007">
        <property type="entry name" value="Sodium channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000003">
        <property type="entry name" value="Voltage-dependent sodium channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000049">
        <property type="entry name" value="Voltage-dependent sodium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058542">
        <property type="entry name" value="IQ_SCN5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001696">
        <property type="entry name" value="Na_channel_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044564">
        <property type="entry name" value="Na_chnl_inactivation_gate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010526">
        <property type="entry name" value="Na_trans_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043203">
        <property type="entry name" value="VGCC_Ca_Na"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037:SF208">
        <property type="entry name" value="SODIUM CHANNEL PROTEIN TYPE 10 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10037">
        <property type="entry name" value="VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24609">
        <property type="entry name" value="IQ_SCN5A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06512">
        <property type="entry name" value="Na_trans_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00170">
        <property type="entry name" value="NACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 22" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 22" id="KW-0915">Sodium</keyword>
    <keyword evidence="4 22" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="17 22" id="KW-0739">Sodium transport</keyword>
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</entry>
<entry dataset="TrEMBL" created="2010-01-19" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="journal article" date="2009" name="PLoS Genet." volume="5" first="e1000688" last="e1000688">
            <title>A novel system of polymorphic and diverse NK cell receptors in primates.</title>
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                <person name="Averdam A."/>
                <person name="Petersen B."/>
                <person name="Rosner C."/>
                <person name="Neff J."/>
                <person name="Roos C."/>
                <person name="Eberle M."/>
                <person name="Aujard F."/>
                <person name="Munch C."/>
                <person name="Schempp W."/>
                <person name="Carrington M."/>
                <person name="Shiina T."/>
                <person name="Inoko H."/>
                <person name="Knaust F."/>
                <person name="Coggill P."/>
                <person name="Sehra H."/>
                <person name="Beck S."/>
                <person name="Abi-Rached L."/>
                <person name="Reinhardt R."/>
                <person name="Walter L."/>
            </authorList>
            <dbReference type="PubMed" id="19834558"/>
            <dbReference type="DOI" id="10.1371/journal.pgen.1000688"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Membrane</location>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
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        <property type="entry name" value="C-type_lectin-like"/>
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        <property type="entry name" value="C-type_lectin-like/link_sf"/>
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        <property type="entry name" value="NKG2/CD94_NK_receptors"/>
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        <property type="entry name" value="NKR-like_CTLD"/>
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        </location>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="234" mass="26542" checksum="35F57BA7244B91FE" modified="2010-01-19" version="1">MDNQTVIYSEMLLAKTPKRQQKKSKDTTSSISETDQEITYAELNLQNAAQDLQRVDRSYHYKDLLLPQEKLIAGILGILCLVLIMSTVVTSLVNSSRVPQEQNNFSQTTRTQKACNCGRCPEEWLTYSTNCYYISKETKTWDDSVKACASKNSNLLYIDNEEEMKFLSSLSKKAWIGVFRNSSEQPWISRNGSTFKLKIEETVSGRHNCAVLQSPSLHSGGCESTKTYICKHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U2RII2</accession>
    <name>A0A0U2RII2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">NADH-ubiquinone oxidoreductase chain 2</fullName>
            <ecNumber evidence="3 18">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ND2</name>
        <name evidence="22" type="synonym">MT-ND2</name>
    </gene>
    <organism evidence="21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="21 22"/>
    <reference evidence="21" key="1">
        <citation type="journal article" date="2016" name="Mitochondrial DNA A DNA Mapp Seq Anal" volume="27" first="3514" last="3516">
            <title>Complete mitochondrial genome of the gray mouse lemur, Microcebus murinus (Primates, Cheirogaleidae).</title>
            <authorList>
                <person name="Lecompte E."/>
                <person name="Crouau-Roy B."/>
                <person name="Aujard F."/>
                <person name="Holota H."/>
                <person name="Murienne J."/>
            </authorList>
            <dbReference type="PubMed" id="27158869"/>
            <dbReference type="DOI" id="10.3109/19401736.2015.1074196"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">920FAG</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 18"/>
    <dbReference type="EMBL" id="KR911908">
        <property type="protein sequence ID" value="ALP29117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009192250.1">
        <property type="nucleotide sequence ID" value="NC_028718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U2RII2"/>
    <dbReference type="Ensembl" id="ENSMICT00000055164.1">
        <property type="protein sequence ID" value="ENSMICP00000029192.1"/>
        <property type="gene ID" value="ENSMICG00000038730.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26823994"/>
    <dbReference type="KEGG" id="mmur:26823994"/>
    <dbReference type="CTD" id="4536"/>
    <dbReference type="GeneTree" id="ENSGT00730000111348"/>
    <dbReference type="OrthoDB" id="4092844at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMICG00000038730">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072593">
        <property type="term" value="P:reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050175">
        <property type="entry name" value="Complex_I_Subunit_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010933">
        <property type="entry name" value="NADH_DH_su2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003917">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46552">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46552:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06444">
        <property type="entry name" value="NADH_dehy_S2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01436">
        <property type="entry name" value="NADHDHGNASE2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 18" id="KW-0520">NAD</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 18" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="13 18" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="19">
        <location>
            <begin position="23"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="NADH dehydrogenase subunit 2 C-terminal" evidence="20">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="ALP29117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="349" mass="39309" checksum="82E68FD2DB6551FA" modified="2016-03-16" version="1">MKLPILTIVMTTIFTGTMLTMISSHWLLIWIGLEINMLSIIPILTKNQKPRSTEAATKYFLTQATASMLLMFTIVFNAMHSGQWTTTNIDPNNMIVSLTMIIALTMKLGMTPFHFWVPEVTQGVSLMTGMLLLTWQKLAPISIMMQMFTSINSIILLLIALMSVLVGGWGGLNQTQLRKILAYSSIAHMGWMMAILTFCPSLTMLNLLIYLMLTIIMFTMLNMNTNTTTLTLSNLWNKSPTITMMILISLLSLGGLPPLTGFLPKWVIIQELTKNNNIAMATVMAIMALLNLYFYMRLIYSTSLTLFPTPNNIKMKWQFQPKKRSLFLSPLIILSTLTLPLSPVFSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EAF2</accession>
    <name>A0A8B7EAF2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Growth differentiation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GDF1</name>
        <name evidence="12" type="synonym">CERS1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027579">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591114.1">
        <property type="nucleotide sequence ID" value="XM_012735660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EAF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000043495.2">
        <property type="protein sequence ID" value="ENSMICP00000033002.2"/>
        <property type="gene ID" value="ENSMICG00000031178.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105855007"/>
    <dbReference type="CTD" id="2657"/>
    <dbReference type="GeneTree" id="ENSGT00940000162926"/>
    <dbReference type="OrthoDB" id="5987191at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090092">
        <property type="term" value="P:regulation of transmembrane receptor protein serine/threonine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF151">
        <property type="entry name" value="EMBRYONIC GROWTH_DIFFERENTIATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00669">
        <property type="entry name" value="INHIBINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133305" evidence="10">
        <location>
            <begin position="28"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="11">
        <location>
            <begin position="248"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033002.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="370" mass="39108" checksum="BDA2537C0441ADA1" modified="2022-01-19" version="1">MRPLCPRPGRHLLLLLLALLPPRPCPARAPVPPGPAAALLRALGLRDAPQGAPTLRSVPPVMWRLFRRRDPQETRSGLRRTPPGTTLRPCHVEELGVAGNIVRHIPDRGAAARPPEPASAAGQCPAWTVVFDLSAVDPAERPSRARLELRFAAAAAPASGWELSVAQAGEAAGPGPGAVLLRQAVPALESPVRAELLGAAWARNASVPRSLRLALALRPRGPAACARLAEASLLLVTLDPRLCHPLARPRREAEPAAGGGLGGACRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPAALSGPGGPPALNHAVLRALMHGASPGAGGLPCCVPARLSPISMLFFDNSDNVVLRHYEDMVVDECGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EC90</accession>
    <name>A0A8B7EC90_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Junctophilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">JPH1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the junctophilin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590807.1">
        <property type="nucleotide sequence ID" value="XM_012735353.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590808.1">
        <property type="nucleotide sequence ID" value="XM_012735354.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590809.1">
        <property type="nucleotide sequence ID" value="XM_012735355.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590810.1">
        <property type="nucleotide sequence ID" value="XM_012735356.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590811.1">
        <property type="nucleotide sequence ID" value="XM_012735357.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EC90"/>
    <dbReference type="Ensembl" id="ENSMICT00000000666.3">
        <property type="protein sequence ID" value="ENSMICP00000000597.2"/>
        <property type="gene ID" value="ENSMICG00000000667.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105854792"/>
    <dbReference type="KEGG" id="mmur:105854792"/>
    <dbReference type="CTD" id="56704"/>
    <dbReference type="GeneTree" id="ENSGT00940000156130"/>
    <dbReference type="OrthoDB" id="284854at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030314">
        <property type="term" value="C:junctional membrane complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014701">
        <property type="term" value="C:junctional sarcoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008307">
        <property type="term" value="F:structural constituent of muscle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060402">
        <property type="term" value="P:calcium ion transport into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010882">
        <property type="term" value="P:regulation of cardiac muscle contraction by calcium ion signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010880">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000001">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000003">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000012">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017191">
        <property type="entry name" value="Junctophilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085">
        <property type="entry name" value="GH28348P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23085:SF6">
        <property type="entry name" value="JUNCTOPHILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037387">
        <property type="entry name" value="Junctophilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="584"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000597.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="662" mass="71818" checksum="733C913B918C1CDD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EFZ5</accession>
    <name>A0A8B7EFZ5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-acyl fatty acid synthase thioesterase, medium chain</fullName>
            <ecNumber evidence="2">3.1.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Oleoyl-ACP hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Thioesterase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Thioesterase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">OLAH</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>decanoyl-CoA + H2O = decanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40059"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:27689"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:40060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts (via C-terminus) with FASN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.14" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03028367">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593445.1">
        <property type="nucleotide sequence ID" value="XM_012737991.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593446.1">
        <property type="nucleotide sequence ID" value="XM_012737992.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593448.1">
        <property type="nucleotide sequence ID" value="XM_012737994.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593449.1">
        <property type="nucleotide sequence ID" value="XM_012737995.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593450.1">
        <property type="nucleotide sequence ID" value="XM_012737996.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593451.1">
        <property type="nucleotide sequence ID" value="XM_012737997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EFZ5"/>
    <dbReference type="ESTHER" id="micmu-a0a8b7efz5">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065142.1">
        <property type="protein sequence ID" value="ENSMICP00000041428.1"/>
        <property type="gene ID" value="ENSMICG00000045566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105856354"/>
    <dbReference type="KEGG" id="mmur:105856354"/>
    <dbReference type="CTD" id="55301"/>
    <dbReference type="GeneTree" id="ENSGT00390000015518"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000153">
        <property type="entry name" value="Surfactin synthase thioesterase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487:SF0">
        <property type="entry name" value="S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="19">
        <location>
            <begin position="28"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="265" mass="30030" checksum="06915AD1E0B9F2C3" modified="2022-01-19" version="1">MEGRDQAGRTRNEKVLNCLYENPDAIFKLICFPWAGGGSMYFAKWGQQIHESLEVHSVRLAGRESRLEEPFAKDIYQIVDEVLCAVLPVIHDKPFAFFGHSMGCYIALLTALKLKEKYKLEPVHFFVSSATPPYSKARVYIPEDKGLSEEQLYHVLNDFGGTPQHLVEDKELFQQYIPILMSDMHVMSTYTCDTPSKAVLSCDLTCFVGTKDIAKDMEAWKGITNGSTNLHVLPGDHFYLKEPGNEKFLKDYIAKCLEISSLANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EIP8</accession>
    <name>A0A8B7EIP8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Shugoshin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SGO2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594527.1">
        <property type="nucleotide sequence ID" value="XM_012739073.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594528.1">
        <property type="nucleotide sequence ID" value="XM_012739074.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EIP8"/>
    <dbReference type="Ensembl" id="ENSMICT00000043779.2">
        <property type="protein sequence ID" value="ENSMICP00000038456.1"/>
        <property type="gene ID" value="ENSMICG00000033463.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856982"/>
    <dbReference type="KEGG" id="mmur:105856982"/>
    <dbReference type="CTD" id="151246"/>
    <dbReference type="GeneTree" id="ENSGT00940000154107"/>
    <dbReference type="OrthoDB" id="5990092at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038889">
        <property type="entry name" value="Shugoshin1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577">
        <property type="entry name" value="SHUGOSHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21577:SF3">
        <property type="entry name" value="SHUGOSHIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="404"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1023"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1199"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1212"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1248"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1260" mass="144122" checksum="017A9251C6FFBECB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EJJ4</accession>
    <name>A0A8B7EJJ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105856576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03031284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593872.1">
        <property type="nucleotide sequence ID" value="XM_012738418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EJJ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000006436.3">
        <property type="protein sequence ID" value="ENSMICP00000005876.1"/>
        <property type="gene ID" value="ENSMICG00000006437.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000042698.2">
        <property type="protein sequence ID" value="ENSMICP00000039464.2"/>
        <property type="gene ID" value="ENSMICG00000006437.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856576"/>
    <dbReference type="KEGG" id="mmur:105856576"/>
    <dbReference type="GeneTree" id="ENSGT00940000155234"/>
    <dbReference type="OMA" id="EPWYCFA"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08299">
        <property type="entry name" value="alcohol_DH_class_I_II_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="17"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039464.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="375" mass="39944" checksum="C1A8CAD4F4A377A3" modified="2022-01-19" version="1">MSTAGKVIKCKAAVLWELNKPFSIEEVEVAPPKAYEVRVKMVAVGICRTDDHVVSGTMVLPLPVIAGHESAGIVESIGEGVTTVKPGDKVIPLFTPQCGKCRICKHPESNFCLKNDLGKPRGTMQDGTTRFTCRGKPVHHFLGISTFSQYTVMDENSVAKIDAASPLEKVCLIGCGFSTGYGSAVKIAKVTPGSSCAVFGLGGVGLSVIMGCKAAGAARIIAVDINKSKFAKARELGATECINPQDHKKPIQEVITEMTDGGVDFSFEVVGRLDTTMAALLCCHQACGTTVSVGIPPDSQNLSMNPLILLTGRTWKGGVFGGYKSKESVPKLVADFMAKKFPLDPLITNVMPFEKINEGFDLLRSGKSIRTVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EKB6</accession>
    <name>A0A8B7EKB6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FHF complex subunit HOOK interacting protein 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FHIP2B</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FHIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023724">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594707.1">
        <property type="nucleotide sequence ID" value="XM_012739253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EKB6"/>
    <dbReference type="Ensembl" id="ENSMICT00000000987.3">
        <property type="protein sequence ID" value="ENSMICP00000000895.2"/>
        <property type="gene ID" value="ENSMICG00000000981.3"/>
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    <dbReference type="KEGG" id="mmur:105857131"/>
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    <dbReference type="GeneTree" id="ENSGT00950000182936"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
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    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
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    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
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        <property type="entry name" value="FHIP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045668">
        <property type="entry name" value="FHIP_KELAA_motif"/>
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    <dbReference type="PANTHER" id="PTHR21705:SF9">
        <property type="entry name" value="FHF COMPLEX SUBUNIT HOOK-INTERACTING PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF5917"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="KELAA"/>
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        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="601"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000895.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="744" mass="82501" checksum="FCF747EC75FCB636" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EPX6</accession>
    <name>A0A8B7EPX6_MICMU</name>
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        <submittedName>
            <fullName evidence="10">Lymphocyte antigen 6 family member G6F</fullName>
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    </protein>
    <gene>
        <name evidence="10" type="primary">LY6G6F</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007266">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596461.1">
        <property type="nucleotide sequence ID" value="XM_012741007.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7EPX6"/>
    <dbReference type="Ensembl" id="ENSMICT00000067748.1">
        <property type="protein sequence ID" value="ENSMICP00000048597.1"/>
        <property type="gene ID" value="ENSMICG00000028884.2"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000015960"/>
    <dbReference type="OrthoDB" id="9937043at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026524">
        <property type="entry name" value="LY6G6d/LY6G6f"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32286">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32286:SF10">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6 COMPLEX LOCUS PROTEIN G6F"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133407" evidence="8">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="9">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048597.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="295" mass="32063" checksum="34F579157A4BF396" modified="2022-01-19" version="1">MAVLFLLLLFLCGTPQAAADNIWAIYVALGEAMELPCPSPPTLHGDELLSWFHSPVAGSFTTLVAQVHVASPAPDPGKPRRESRLKLLGNYSLWLEGSKEGDAGRYWCAVLGQHHDYQNWRVYDVSVLRGSQLSARAADGSPCSVLLCSVVPSRRLDSVTWQEGRGPVRGRVQSFWGDGAALLLVCPGEGLPEPRGHRPRTIRCLMPHNKGVSFSLPASPALCAPATGWDVPWILLLLLTVGQGVAILALTIVLWSQRARGAPGRDASIPQFKPEIQVYENIHLARLSPPAHKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="8">Shisa family member 4</fullName>
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        <name evidence="8" type="primary">SHISA4</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03029829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012744418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EWY1"/>
    <dbReference type="Ensembl" id="ENSMICT00000065482.1">
        <property type="protein sequence ID" value="ENSMICP00000047020.1"/>
        <property type="gene ID" value="ENSMICG00000048002.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="mmur:105860044"/>
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    <dbReference type="GeneTree" id="ENSGT00730000111186"/>
    <dbReference type="OrthoDB" id="10010453at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026910">
        <property type="entry name" value="Shisa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053891">
        <property type="entry name" value="Shisa_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395:SF5">
        <property type="entry name" value="PROTEIN SHISA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31395">
        <property type="entry name" value="SHISA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13908">
        <property type="entry name" value="Shisa_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133460" evidence="6">
        <location>
            <begin position="28"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Shisa N-terminal" evidence="7">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="197" mass="21496" checksum="346D6A8446C64D51" modified="2022-01-19" version="1">MRPAGLREAAPLAGIALLLLGAPLALAGEDCLWYLDRNGSWHPGFSCEFFTFCCGTCYQRYCCRDLSLLITERQQKHCLAFSPKTIAGIASAVILFVAVVATTICCFLCSCCYLYRRRQQLQSPFEGQEIPMTGIPVQPVYPYPQDPKAGPAPPQPGFMYPPSGPAPQYPMYPAGPPIYNPAAPPPYMPPQPSYPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F4V7</accession>
    <name>A0A8B7F4V7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">pre-rRNA processing protein FTSJ3</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein ftsJ homolog 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Putative rRNA methyltransferase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">FTSJ3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with NIP7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03020238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602721.1">
        <property type="nucleotide sequence ID" value="XM_012747267.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F4V7"/>
    <dbReference type="Ensembl" id="ENSMICT00000065485.1">
        <property type="protein sequence ID" value="ENSMICP00000049865.1"/>
        <property type="gene ID" value="ENSMICG00000045996.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105861620"/>
    <dbReference type="KEGG" id="mmur:105861620"/>
    <dbReference type="CTD" id="117246"/>
    <dbReference type="GeneTree" id="ENSGT00550000075004"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="232"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="623"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="333"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="458"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="545"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="803"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="732"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="803"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="814"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="839" mass="95522" checksum="6791256B8D9406B4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F5P1</accession>
    <name>A0A8B7F5P1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KIF18A</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603041.1">
        <property type="nucleotide sequence ID" value="XM_012747587.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603049.1">
        <property type="nucleotide sequence ID" value="XM_012747595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F5P1"/>
    <dbReference type="Ensembl" id="ENSMICT00000005167.3">
        <property type="protein sequence ID" value="ENSMICP00000004711.2"/>
        <property type="gene ID" value="ENSMICG00000005169.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067124.1">
        <property type="protein sequence ID" value="ENSMICP00000045987.1"/>
        <property type="gene ID" value="ENSMICG00000005169.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861796"/>
    <dbReference type="KEGG" id="mmur:105861796"/>
    <dbReference type="CTD" id="81930"/>
    <dbReference type="GeneTree" id="ENSGT00940000159058"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070463">
        <property type="term" value="F:tubulin-dependent ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000027">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF73">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11 12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="11"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="783"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="830"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="377"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="679"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="834"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="854"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="898" mass="102564" checksum="15794664CD01C1F2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F861</accession>
    <name>A0A8B7F861_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">IKAROS family zinc finger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">IKZF2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the Ikaros C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010810">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603994.1">
        <property type="nucleotide sequence ID" value="XM_012748540.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603995.1">
        <property type="nucleotide sequence ID" value="XM_012748541.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603996.1">
        <property type="nucleotide sequence ID" value="XM_012748542.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F861"/>
    <dbReference type="Ensembl" id="ENSMICT00000013858.3">
        <property type="protein sequence ID" value="ENSMICP00000012644.3"/>
        <property type="gene ID" value="ENSMICG00000013862.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000037164.2">
        <property type="protein sequence ID" value="ENSMICP00000030574.2"/>
        <property type="gene ID" value="ENSMICG00000013862.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065381.1">
        <property type="protein sequence ID" value="ENSMICP00000044980.1"/>
        <property type="gene ID" value="ENSMICG00000013862.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065881.1">
        <property type="protein sequence ID" value="ENSMICP00000040501.1"/>
        <property type="gene ID" value="ENSMICG00000013862.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862318"/>
    <dbReference type="CTD" id="22807"/>
    <dbReference type="GeneTree" id="ENSGT00940000157137"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000073">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000525">
        <property type="entry name" value="IKAROS family zinc finger 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000124">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000372">
        <property type="entry name" value="IKAROS family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000168">
        <property type="entry name" value="zinc finger protein Eos isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF33">
        <property type="entry name" value="ZINC FINGER PROTEIN HELIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="17">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="28"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="368"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="526" mass="59557" checksum="8C67E8CC22FF049B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FK01</accession>
    <name>A0A8B7FK01_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Metaxin-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial outer membrane import complex protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MTX2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport of proteins into the mitochondrion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with MTX1/metaxin-1. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and QIL1/MIC13. This complex was also known under the names MINOS or MitOS complex. The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9. The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608865.1">
        <property type="nucleotide sequence ID" value="XM_012753411.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FK01"/>
    <dbReference type="Ensembl" id="ENSMICT00000035519.2">
        <property type="protein sequence ID" value="ENSMICP00000031907.1"/>
        <property type="gene ID" value="ENSMICG00000004295.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865071"/>
    <dbReference type="KEGG" id="mmur:105865071"/>
    <dbReference type="CTD" id="10651"/>
    <dbReference type="GeneTree" id="ENSGT00950000182919"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03211">
        <property type="entry name" value="GST_C_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03079">
        <property type="entry name" value="GST_N_Metaxin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000033">
        <property type="entry name" value="metaxin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF38">
        <property type="entry name" value="METAXIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="13">
        <location>
            <begin position="41"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="14">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="263" mass="29887" checksum="C07D5DAA885D4A82" modified="2022-01-19" version="1">MSLVAEAFVSQIAATEPWPENATLYQQLKGEQILLSDNAASLAVQAFLQMCNLPIKVVCRANAEYMSPSGKVPFIHVGNQVVSELGPIVQFVKAKGHSLSDRLDEVQKAEMKAYMELVNNMLLTAELYLQWCDEATVGEITHARYGSPYPWPLNHILAYQKQWEVKRKMKAIGWGKKTLDQVLEDVDQCCQALSQRLGTQPYFFNKQPTELDALVFGHLYTILTTQLTNDELSEKVKNYSNLLAFCRRIEQHYFEDHGRGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FLY4</accession>
    <name>A0A8B7FLY4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kallikrein related peptidase 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">KLK6</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609667.1">
        <property type="nucleotide sequence ID" value="XM_012754213.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609668.1">
        <property type="nucleotide sequence ID" value="XM_012754214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FLY4"/>
    <dbReference type="Ensembl" id="ENSMICT00000037243.2">
        <property type="protein sequence ID" value="ENSMICP00000016852.1"/>
        <property type="gene ID" value="ENSMICG00000029131.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105865560"/>
    <dbReference type="KEGG" id="mmur:105865560"/>
    <dbReference type="CTD" id="5653"/>
    <dbReference type="GeneTree" id="ENSGT01030000234551"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045745">
        <property type="term" value="P:positive regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000021">
        <property type="entry name" value="Kallikrein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000041">
        <property type="entry name" value="kallikrein-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF19">
        <property type="entry name" value="KALLIKREIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133645" evidence="13">
        <location>
            <begin position="17"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="14">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="244" mass="26910" checksum="6CADC46196489E78" modified="2022-01-19" version="1">MRRLIAALVLVAAAWAEEQEKVVQGGPCEETSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVYLGKHNLQQRESSQEQSSVVRAVTHPGYDAATHDQDIMLLRLAHRAKLSEHIQPILLEKDCSANHTSCHILGWGKTADGDFPDTIQCAYIHLVPREECERAYPGQITQNMVCAGDEKHGKDSCQGDSGGPLVCGDRLRGLVSWGNIPCGSKEKPGVYTNVCRYNNWIRKIIQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FPP9</accession>
    <name>A0A8B7FPP9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BPI fold containing family B member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BPIFB4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021631">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610771.1">
        <property type="nucleotide sequence ID" value="XM_012755317.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FPP9"/>
    <dbReference type="Ensembl" id="ENSMICT00000036852.2">
        <property type="protein sequence ID" value="ENSMICP00000028337.1"/>
        <property type="gene ID" value="ENSMICG00000026403.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105866125"/>
    <dbReference type="KEGG" id="mmur:105866125"/>
    <dbReference type="CTD" id="149954"/>
    <dbReference type="GeneTree" id="ENSGT01100000263546"/>
    <dbReference type="OrthoDB" id="9905567at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.20.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017943">
        <property type="entry name" value="Bactericidal_perm-incr_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051660">
        <property type="entry name" value="BPI_fold-BPI/LBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001124">
        <property type="entry name" value="Lipid-bd_serum_glycop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017942">
        <property type="entry name" value="Lipid-bd_serum_glycop_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019:SF4">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46019">
        <property type="entry name" value="BPI FOLD-CONTAINING FAMILY B MEMBER 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01273">
        <property type="entry name" value="LBP_BPI_CETP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02886">
        <property type="entry name" value="LBP_BPI_CETP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00328">
        <property type="entry name" value="BPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00329">
        <property type="entry name" value="BPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55394">
        <property type="entry name" value="Bactericidal permeability-increasing protein, BPI"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133649" evidence="2">
        <location>
            <begin position="18"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein N-terminal" evidence="3">
        <location>
            <begin position="173"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Lipid-binding serum glycoprotein C-terminal" evidence="4">
        <location>
            <begin position="417"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="619" mass="65248" checksum="0CDE6C7D176AAE48" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FRP2</accession>
    <name>A0A8B7FRP2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chromobox 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CBX2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03019770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611642.1">
        <property type="nucleotide sequence ID" value="XM_012756188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FRP2"/>
    <dbReference type="Ensembl" id="ENSMICT00000007809.3">
        <property type="protein sequence ID" value="ENSMICP00000007107.2"/>
        <property type="gene ID" value="ENSMICG00000007813.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866696"/>
    <dbReference type="KEGG" id="mmur:105866696"/>
    <dbReference type="CTD" id="84733"/>
    <dbReference type="GeneTree" id="ENSGT00940000158816"/>
    <dbReference type="OrthoDB" id="8192126at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
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        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035102">
        <property type="term" value="C:PRC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062072">
        <property type="term" value="F:histone H3K9me2/3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045137">
        <property type="term" value="P:development of primary sexual characteristics"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="CD_Cbx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000006">
        <property type="entry name" value="Chromobox protein homolog 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042796">
        <property type="entry name" value="CBX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033773">
        <property type="entry name" value="CBX7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46860">
        <property type="entry name" value="CHROMOBOX PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46860:SF1">
        <property type="entry name" value="CHROMOBOX PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17218">
        <property type="entry name" value="CBX7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="8">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="295"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007107.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="533" mass="55407" checksum="1D262F188B89FD3B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FRU5</accession>
    <name>A0A8B7FRU5_MICMU</name>
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        <recommendedName>
            <fullName evidence="3">Cysteine-rich PDZ-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cysteine-rich interactor of PDZ three</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CRIPT</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRIPT family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611302.1">
        <property type="nucleotide sequence ID" value="XM_012755848.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FRU5"/>
    <dbReference type="SMR" id="A0A8B7FRU5"/>
    <dbReference type="Ensembl" id="ENSMICT00000069466.1">
        <property type="protein sequence ID" value="ENSMICP00000043364.1"/>
        <property type="gene ID" value="ENSMICG00000046155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105866511"/>
    <dbReference type="KEGG" id="mmur:105866511"/>
    <dbReference type="CTD" id="9419"/>
    <dbReference type="GeneTree" id="ENSGT00950000183100"/>
    <dbReference type="OrthoDB" id="17366at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019367">
        <property type="entry name" value="PDZ-binding_CRIPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11805:SF1">
        <property type="entry name" value="CYSTEINE-RICH PDZ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10235">
        <property type="entry name" value="Cript"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="101" mass="11216" checksum="161B0F4CA87DFBAD" modified="2022-01-19" version="1">MVCEKCEKKLGTVITPDTWKDGARNTTESGGRKLNENKALTSKKARFDPYGKNKFSTCRICKSSVHQPGSHYCQGCAYKKGICAMCGKKVLDTKNYKQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FTN0</accession>
    <name>A0A8B7FTN0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GNGT1</name>
        <name evidence="11" type="synonym">LOC105867248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">G proteins are composed of 3 units; alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <orientation evidence="1 9">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015484">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612517.1">
        <property type="nucleotide sequence ID" value="XM_012757063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FTN0"/>
    <dbReference type="SMR" id="A0A8B7FTN0"/>
    <dbReference type="Ensembl" id="ENSMICT00000035980.2">
        <property type="protein sequence ID" value="ENSMICP00000028520.1"/>
        <property type="gene ID" value="ENSMICG00000014546.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867248"/>
    <dbReference type="KEGG" id="mmur:105867248"/>
    <dbReference type="GeneTree" id="ENSGT01100000263525"/>
    <dbReference type="OMA" id="CEEVMEY"/>
    <dbReference type="OrthoDB" id="9933679at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042462">
        <property type="term" value="P:eye photoreceptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00068">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000001">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001770">
        <property type="entry name" value="G-protein_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13809">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00321">
        <property type="entry name" value="GPROTEING"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="10">
        <location>
            <begin position="5"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="74" mass="8528" checksum="3ABB43EF45CE02F4" modified="2022-01-19" version="1">MPVINIEDLTEKDKLKMEVDQLKKEVTLERMMVSKCCEEVRDYIEERSGEDPLVKGIPEDKNPFKELKGGCVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G0V5</accession>
    <name>A0A8B7G0V5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">calcium/calmodulin-dependent protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CAMK2G</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.17" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03019035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G4B7</accession>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        </citation>
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    </evidence>
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</entry>
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    <accession>A0A8B7G7P2</accession>
    <name>A0A8B7G7P2_MICMU</name>
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        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPS24</name>
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    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Eutheria</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617915.1">
        <property type="nucleotide sequence ID" value="XM_012762461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G7P2"/>
    <dbReference type="SMR" id="A0A8B7G7P2"/>
    <dbReference type="Ensembl" id="ENSMICT00000005950.3">
        <property type="protein sequence ID" value="ENSMICP00000005427.3"/>
        <property type="gene ID" value="ENSMICG00000005951.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870121"/>
    <dbReference type="KEGG" id="mmur:105870121"/>
    <dbReference type="CTD" id="6229"/>
    <dbReference type="GeneTree" id="ENSGT00390000000153"/>
    <dbReference type="OrthoDB" id="9532209at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005427.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="133" mass="15423" checksum="CE9065C0764D60A6" modified="2022-01-19" version="1">MNDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEIREKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSLDYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVRGTAKANVGAGKKPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8V7</accession>
    <name>A0A8B7G8V7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Keratin 74</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KRT74</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618581.1">
        <property type="nucleotide sequence ID" value="XM_012763127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8V7"/>
    <dbReference type="Ensembl" id="ENSMICT00000002202.3">
        <property type="protein sequence ID" value="ENSMICP00000002015.2"/>
        <property type="gene ID" value="ENSMICG00000002204.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870496"/>
    <dbReference type="KEGG" id="mmur:105870496"/>
    <dbReference type="CTD" id="121391"/>
    <dbReference type="GeneTree" id="ENSGT00940000162774"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF5">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="140"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="480"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="195"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="351"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002015.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="528" mass="57658" checksum="D30B1F629CA0E3BF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GAP9</accession>
    <name>A0A8B7GAP9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">MORC family CW-type zinc finger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">MORC2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012763935.3"/>
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    <dbReference type="Ensembl" id="ENSMICT00000008542.3">
        <property type="protein sequence ID" value="ENSMICP00000007781.3"/>
        <property type="gene ID" value="ENSMICG00000008540.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000153998"/>
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        <property type="component" value="Chromosome 21"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Sexton D."/>
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                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
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                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD3, a base containing 6 ATPases and few additional components. Interacts with UBQLN1 (via ubiquitin-like domain). Interacts with ERCC6.</text>
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        <text evidence="2">Belongs to the proteasome subunit S3 family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of protein catabolic process"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CSN3"/>
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        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PCI" evidence="13">
        <location>
            <begin position="284"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="498"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="499"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00063952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00080169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="532" mass="60824" checksum="0149B7D286E51E75" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GPE3</accession>
    <name>A0A8B7GPE3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Four and a half LIM domains protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FHL5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with CREM (via the third LIM domain). Interacts (via second LIM domain) with SPAG8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624894.1">
        <property type="nucleotide sequence ID" value="XM_012769440.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624895.1">
        <property type="nucleotide sequence ID" value="XM_012769441.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GPE3"/>
    <dbReference type="Ensembl" id="ENSMICT00000032287.2">
        <property type="protein sequence ID" value="ENSMICP00000024378.1"/>
        <property type="gene ID" value="ENSMICG00000009176.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874019"/>
    <dbReference type="KEGG" id="mmur:105874019"/>
    <dbReference type="CTD" id="9457"/>
    <dbReference type="GeneTree" id="ENSGT00950000183028"/>
    <dbReference type="OrthoDB" id="274660at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09343">
        <property type="entry name" value="LIM1_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09428">
        <property type="entry name" value="LIM2_FHL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09347">
        <property type="entry name" value="LIM4_FHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000013">
        <property type="entry name" value="Four and a half LIM domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000030">
        <property type="entry name" value="Four and a half LIM domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000048">
        <property type="entry name" value="Four and a half LIM domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000049">
        <property type="entry name" value="Four and a half LIM domains protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042947">
        <property type="entry name" value="FHL5_LIM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056807">
        <property type="entry name" value="LIM_FHL1/2/3/5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF7">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25076">
        <property type="entry name" value="LIM_FHL2-3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="39"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="12">
        <location>
            <begin position="223"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="284" mass="32842" checksum="F7E7C2BB99798C6E" modified="2022-01-19" version="1">MTTVQFDCQYCTASLLGKKYVLKDDNPYCVSCYDHIFSNYCEECKEPIESDSKDLCYKDRHWHEGCFKCTKCSRSLVEKPFAAKDERLLCTECYSNECSSKCFHCKRTIMPGSRKMEFKGNYWHETCFVCEHCRQPIGTKPLISKENGNYCVLCFEKEFAQYCNFCKKVITSGGITFHDQLWHKECFLCSGCRKELSAEEFMSRDDYPFCLDCYHHLFAKKCAACSKSITGLRGAKFICFQDRQWHSECFNCGKCSVSLVGEGFLTQNKEIFCRKCGSGVDTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GRE1</accession>
    <name>A0A8B7GRE1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger protein 445</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZNF445</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625821.1">
        <property type="nucleotide sequence ID" value="XM_012770367.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625822.1">
        <property type="nucleotide sequence ID" value="XM_012770368.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625823.1">
        <property type="nucleotide sequence ID" value="XM_012770369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GRE1"/>
    <dbReference type="Ensembl" id="ENSMICT00000051070.2">
        <property type="protein sequence ID" value="ENSMICP00000033198.1"/>
        <property type="gene ID" value="ENSMICG00000038112.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874471"/>
    <dbReference type="KEGG" id="mmur:105874471"/>
    <dbReference type="CTD" id="353274"/>
    <dbReference type="GeneTree" id="ENSGT00900000141186"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010385">
        <property type="term" value="F:double-stranded methylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044726">
        <property type="term" value="P:epigenetic programing of female pronucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001480">
        <property type="entry name" value="Si:cabz01071911.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000151">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000178">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000870">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001124">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001966">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002001">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000038">
        <property type="entry name" value="Zinc finger protein 624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF242">
        <property type="entry name" value="ZINC FINGER PROTEIN 628"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="16">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="17">
        <location>
            <begin position="234"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="544"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="842"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="870"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="980"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="733"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00067827"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1033" mass="120126" checksum="2A5B8AE1C18363D9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GS84</accession>
    <name>A0A8B7GS84_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Matrix metallopeptidase 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">MMP20</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006770">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626026.1">
        <property type="nucleotide sequence ID" value="XM_012770572.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GS84"/>
    <dbReference type="Ensembl" id="ENSMICT00000002937.3">
        <property type="protein sequence ID" value="ENSMICP00000002674.1"/>
        <property type="gene ID" value="ENSMICG00000002940.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874594"/>
    <dbReference type="KEGG" id="mmur:105874594"/>
    <dbReference type="CTD" id="9313"/>
    <dbReference type="GeneTree" id="ENSGT00940000161277"/>
    <dbReference type="OMA" id="YKNPYGF"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097186">
        <property type="term" value="P:amelogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF125">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133941" evidence="21">
        <location>
            <begin position="23"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="22">
        <location>
            <begin position="113"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="293"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="344"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="391"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="20">
        <location>
            <begin position="440"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="19">
        <location>
            <begin position="98"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="17">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
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            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="296"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR621190-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="483" mass="54053" checksum="96BA22316A811D91" modified="2022-01-19" version="1">MKVLPASGLAVLLITALKLSTAAPSLFSATPRTWRNNYHLAQAYLDKYYTKKGGHQIAEMAARGGNSMVKKIKELQAFFGLQVTGKLDPTTMDVIKRPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSAAEVDKAIDMALRAWSSAVPLNFVRVNAGEADIMISFETGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGMNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYQNPYGFRLPSDDVKGIQALYGPRKPYLGNPAMPHGPPHKPPTPDLCDSSASFDAVTMLGKELLFFKDRIFWRRQVHLPSGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHVQRIDAAVYLREPQKTLFFVGDEYYSYDERKRRMEKDYPKNTEEEFSGVSGQIDAAVELNGYIYFFSGPKAYKYDTEKEDVVSVVKSSSWIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GWD2</accession>
    <name>A0A8B7GWD2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glutaredoxin-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GLRX2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627863.1">
        <property type="nucleotide sequence ID" value="XM_012772409.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GWD2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011509.3">
        <property type="protein sequence ID" value="ENSMICP00000010474.2"/>
        <property type="gene ID" value="ENSMICG00000011515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875398"/>
    <dbReference type="KEGG" id="mmur:105875398"/>
    <dbReference type="CTD" id="51022"/>
    <dbReference type="GeneTree" id="ENSGT00940000162420"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000026">
        <property type="entry name" value="Glutaredoxin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011899">
        <property type="entry name" value="Glutaredoxin_euk/vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02180">
        <property type="entry name" value="GRX_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46679:SF1">
        <property type="entry name" value="GLUTAREDOXIN-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="17">
        <location>
            <begin position="60"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010474.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="155" mass="16977" checksum="D7F10AE511F74999" modified="2022-01-19" version="1">MYWRGAALAGTRLLRSGSCSAGRLGGAAASGMGSSISSSLGKSATAPMNQIQETISDHCVVIFSKTSCSYCKMAKKLFHDMNVNYKVVELDMLEYGSQFQDALYKMTGERTVPRIFVNGTFIGGATDTHRLHKEGKLLPLVHQCYLKKSKRKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GZE6</accession>
    <name>A0A8B7GZE6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Interleukin-10 receptor subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">CDw210a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Interleukin-10 receptor subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">IL10RA</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with IL10. Interacts with IL10RB. Interacts (via its cytoplasmic domain) with JAK1 (via N-terminus). Interacts with BTRC; this interaction leads to IL10RA ubiquitination and subsequent degradation. Interacts with STAT3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II cytokine receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007028">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629095.1">
        <property type="nucleotide sequence ID" value="XM_012773641.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GZE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000069052.1">
        <property type="protein sequence ID" value="ENSMICP00000049284.1"/>
        <property type="gene ID" value="ENSMICG00000043191.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105876063"/>
    <dbReference type="KEGG" id="mmur:105876063"/>
    <dbReference type="CTD" id="3587"/>
    <dbReference type="GeneTree" id="ENSGT00510000048847"/>
    <dbReference type="OrthoDB" id="9886749at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004920">
        <property type="term" value="F:interleukin-10 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140105">
        <property type="term" value="P:interleukin-10-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060729">
        <property type="term" value="P:intestinal epithelial structure maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000348">
        <property type="entry name" value="Interleukin 20 receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001488">
        <property type="entry name" value="Interleukin-10 receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015373">
        <property type="entry name" value="Interferon/interleukin_rcp_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050650">
        <property type="entry name" value="Type-II_Cytokine-TF_Rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859">
        <property type="entry name" value="INTERFERON/INTERLEUKIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20859:SF90">
        <property type="entry name" value="INTERLEUKIN-10 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09294">
        <property type="entry name" value="Interfer-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01108">
        <property type="entry name" value="Tissue_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133988" description="Interleukin-10 receptor subunit alpha" evidence="22">
        <location>
            <begin position="24"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="23">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon/interleukin receptor" evidence="24">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="300"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF01108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF09294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="575" mass="62642" checksum="D420A6272E85F3F7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H2L3</accession>
    <name>A0A8B7H2L3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proline dehydrogenase</fullName>
            <ecNumber evidence="9">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PRODH2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>trans-4-hydroxy-L-proline + a quinone = (3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52512"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:58375"/>
            <dbReference type="ChEBI" id="CHEBI:62612"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the proline oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03026971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630456.1">
        <property type="nucleotide sequence ID" value="XM_012775002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H2L3"/>
    <dbReference type="Ensembl" id="ENSMICT00000036081.2">
        <property type="protein sequence ID" value="ENSMICP00000024214.1"/>
        <property type="gene ID" value="ENSMICG00000035697.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876907"/>
    <dbReference type="KEGG" id="mmur:105876908"/>
    <dbReference type="GeneTree" id="ENSGT00390000006265"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF29">
        <property type="entry name" value="HYDROXYPROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="10">
        <location>
            <begin position="181"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="460" mass="50584" checksum="6BD0462167728F97" modified="2022-01-19" version="1">MLRTCRVLYSQAGPSAGGWQPLNFDGGAFHLKGTGELARALLVLRLCAWPPLVTHGLALQAWSQRLLGSRISGALLRASVYGQFVAGETAEEVRGCVRQLQTLGLRPLLAVPTEEEPDSAAKTGEAWYEGNLSAMLQCVDLSRGLQGTPGPARNNLMQLKVTALTSTRLCKELTSWVTRPGASLELSPERLAEAMDSGRNLQVSCLHAEQNRHLQAALRRLHRVAQHARAQDVRLLVDAEYTSLNPALSLLVAALAARWNGPGEGGPWVWNTYQAYLKDTHERLGRDAEAAHRAGLAFGVKLVRGAYLDKERAVAQLQGTEDPTQPDYEATNRSYSRCLELMLNQVSCHGPMCHLMVASHNEESVRQATKRMWELGIPLDGPVCFGQLLGMCDHVSLALGQAGYAVYKSIPYGSLEEVIPYLIRRAQENRSVLQGARREQDLLSQELRRRLLGGGPRLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H5L2</accession>
    <name>A0A8B7H5L2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Tumor necrosis factor ligand superfamily member 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">TNF-related weak inducer of apoptosis</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">TNFSF12</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Homotrimer. Interacts with the angiogenic factor AGGF1/VG5Q.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020552">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631677.1">
        <property type="nucleotide sequence ID" value="XM_012776223.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H5L2"/>
    <dbReference type="Ensembl" id="ENSMICT00000036831.2">
        <property type="protein sequence ID" value="ENSMICP00000026989.1"/>
        <property type="gene ID" value="ENSMICG00000041583.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105877544"/>
    <dbReference type="CTD" id="8742"/>
    <dbReference type="GeneTree" id="ENSGT00940000163167"/>
    <dbReference type="OrthoDB" id="6159739at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097191">
        <property type="term" value="P:extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00184">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000022">
        <property type="entry name" value="Tumor necrosis factor ligand superfamily member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051748">
        <property type="entry name" value="TNF_Ligand_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151">
        <property type="entry name" value="PROTEIN EIGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15151:SF20">
        <property type="entry name" value="TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="11" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-0202">Cytokine</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="24">
        <location>
            <begin position="120"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00053942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00082830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="262" mass="28664" checksum="1B332B2202F6B864" modified="2022-01-19" version="1">MGGAVRQAQPPAPMAARRSQRRRGRRGEPGTALLAPLMLGLGLALVGLGLLLAAVSLGSRASLSAQEPSQGELVAEEDQDPLELKPQRDESREPVPFLNRLIRPRRSAPKGRKTRTRKAIAAHYEVHPRPGQEGAQAGVDGTVSGWEEAKINSSSPLRYDRQVGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDDMLALRCLEEFSATAASSLGPQLRLCQVSGLLPLRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H5L3</accession>
    <name>A0A8B7H5L3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zyg-11 family member A, cell cycle regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ZYG11A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zyg-11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001466">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001467">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631718.1">
        <property type="nucleotide sequence ID" value="XM_012776264.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H5L3"/>
    <dbReference type="Ensembl" id="ENSMICT00000009172.3">
        <property type="protein sequence ID" value="ENSMICP00000008352.2"/>
        <property type="gene ID" value="ENSMICG00000009173.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877569"/>
    <dbReference type="KEGG" id="mmur:105877569"/>
    <dbReference type="CTD" id="440590"/>
    <dbReference type="GeneTree" id="ENSGT00530000063187"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001025">
        <property type="entry name" value="Protein zyg-11 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000086">
        <property type="entry name" value="protein zyg-11 homolog B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055142">
        <property type="entry name" value="ZER1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF20">
        <property type="entry name" value="PROTEIN ZYG-11 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22964">
        <property type="entry name" value="ZER1-like_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Protein zer-1 homolog-like C-terminal" evidence="5">
        <location>
            <begin position="388"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008352.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="762" mass="86065" checksum="0D61FD5BA8A243A8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBX2</accession>
    <name>A0A8B7HBX2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Envoplakin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">210 kDa cornified envelope precursor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p210</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">EVPL</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">May form a homodimer or a heterodimer with PPL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cornified envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the plakin or cytolinker family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634312.1">
        <property type="nucleotide sequence ID" value="XM_012778858.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000045546.2">
        <property type="protein sequence ID" value="ENSMICP00000017523.1"/>
        <property type="gene ID" value="ENSMICG00000007705.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878961"/>
    <dbReference type="KEGG" id="mmur:105878961"/>
    <dbReference type="CTD" id="2125"/>
    <dbReference type="GeneTree" id="ENSGT00940000153578"/>
    <dbReference type="OrthoDB" id="9945740at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045104">
        <property type="term" value="P:intermediate filament cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000178">
        <property type="entry name" value="Envoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1290.10:FF:000010">
        <property type="entry name" value="Envoplakin a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.780:FF:000002">
        <property type="entry name" value="Envoplakin b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000142">
        <property type="entry name" value="Envoplakin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000109">
        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000088">
        <property type="entry name" value="Periplakin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000030">
        <property type="entry name" value="Short stop, isoform K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1290.10">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041615">
        <property type="entry name" value="Desmoplakin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043197">
        <property type="entry name" value="Plakin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035915">
        <property type="entry name" value="Plakin_repeat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058847">
        <property type="entry name" value="Plectin_PPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001101">
        <property type="entry name" value="Plectin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055419">
        <property type="entry name" value="Spectrin_PEPL/EVPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23169:SF7">
        <property type="entry name" value="ENVOPLAKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00681">
        <property type="entry name" value="Plectin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26346">
        <property type="entry name" value="Plectin_PPL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17902">
        <property type="entry name" value="SH3_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23160">
        <property type="entry name" value="Spectrin_1st_PEPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00250">
        <property type="entry name" value="PLEC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00150">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75399">
        <property type="entry name" value="Plakin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0417">Keratinization</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 18" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="413"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="892"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1614"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="478"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="979"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1263"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1395"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="1478"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="71"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="892"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="910"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1614"/>
            <end position="1623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2034" mass="230643" checksum="514BF72A935C02A7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HHG4</accession>
    <name>A0A8B7HHG4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CYB5A</name>
        <name evidence="17" type="synonym">LOC105880290</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HHG4"/>
    <dbReference type="Ensembl" id="ENSMICT00000030920.2">
        <property type="protein sequence ID" value="ENSMICP00000019582.1"/>
        <property type="gene ID" value="ENSMICG00000003395.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880290"/>
    <dbReference type="KEGG" id="mmur:105880290"/>
    <dbReference type="GeneTree" id="ENSGT00940000156770"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 15" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15" id="KW-0408">Iron</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="134" mass="15353" checksum="2A0604D5A445047E" modified="2022-01-19" version="1">MAEQSHKEVKYYTLEEIQKHNHSKSTWLILHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVGHSTDARELSKTYIIGELHPDDRAKLSKPSETLITTVDSKSSWWTNWVIPAISALAVALMYRLYVAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HIH8</accession>
    <name>A0A8B7HIH8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lysophosphatidylglycerol acyltransferase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LPGAT1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637123.1">
        <property type="nucleotide sequence ID" value="XM_012781669.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637124.1">
        <property type="nucleotide sequence ID" value="XM_012781670.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637125.1">
        <property type="nucleotide sequence ID" value="XM_012781671.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637126.1">
        <property type="nucleotide sequence ID" value="XM_012781672.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HIH8"/>
    <dbReference type="Ensembl" id="ENSMICT00000059816.1">
        <property type="protein sequence ID" value="ENSMICP00000041889.1"/>
        <property type="gene ID" value="ENSMICG00000007842.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880544"/>
    <dbReference type="CTD" id="9926"/>
    <dbReference type="GeneTree" id="ENSGT00950000182836"/>
    <dbReference type="OrthoDB" id="5920068at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF2">
        <property type="entry name" value="ACYL-COA:LYSOPHOSPHATIDYLGLYCEROL ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="10">
        <location>
            <begin position="95"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="370" mass="43216" checksum="A9A6EE8FDF0C72FC" modified="2022-01-19" version="1">MAVTLEEAPWLGWILLKALLRFAFMVANNLVAIPSYICYVIILQPLRVLDSKRFWYIEGIMYKWLLGMVASWGWYAGYTVMEWGEDIKAISKDEAMMLVNHQATGDVCTLMMCLQDKGLVVAEMMWLMDHIFKYTNFGIVSLIHGDFFIRQGRSYRDQQLLLLKKHLENYYRSRGRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTHVTLPRCGATKIILSTLVARQENGSPAGGDAKQLGSKSKGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIKDVPLEIDDLTNWLYQRFIEKEDLLSHFYETGAFPPSKGQKEAVSREMTLSNMWIFLIQSFAFLSGYMWYNILQYFYHYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HIQ3</accession>
    <name>A0A8B7HIQ3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Potassium inwardly rectifying channel subfamily J member 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">KCNJ15</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637217.1">
        <property type="nucleotide sequence ID" value="XM_012781763.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637218.1">
        <property type="nucleotide sequence ID" value="XM_012781764.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637219.1">
        <property type="nucleotide sequence ID" value="XM_012781765.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637220.1">
        <property type="nucleotide sequence ID" value="XM_012781766.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637222.1">
        <property type="nucleotide sequence ID" value="XM_012781768.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140319.1">
        <property type="nucleotide sequence ID" value="XM_020284730.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140320.1">
        <property type="nucleotide sequence ID" value="XM_020284731.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140321.1">
        <property type="nucleotide sequence ID" value="XM_020284732.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140322.1">
        <property type="nucleotide sequence ID" value="XM_020284733.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140323.1">
        <property type="nucleotide sequence ID" value="XM_020284734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HIQ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000063217.1">
        <property type="protein sequence ID" value="ENSMICP00000046259.1"/>
        <property type="gene ID" value="ENSMICG00000045136.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880590"/>
    <dbReference type="CTD" id="3772"/>
    <dbReference type="GeneTree" id="ENSGT01140000282491"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000036">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000002">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003270">
        <property type="entry name" value="K_chnl_inward-rec_Kir1.3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF20">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01323">
        <property type="entry name" value="KIR13CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 15" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <keyword evidence="7 15" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="17">
        <location>
            <begin position="31"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="18">
        <location>
            <begin position="179"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="14">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="376" mass="42541" checksum="C7AC55A8E7D11B90" modified="2022-01-19" version="1">MDAMPAATPSAPLVKHAAAGAGLKASRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVIDMKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPSELVSNHTPCIMKVDSLTGAFLFSLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKFSHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVDSSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSYIPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRRSSDCTFYCADSEKQKLEEKYRQEDQRERELRTLLLQQSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HK56</accession>
    <name>A0A8B7HK56_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein kinase TBK1</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">T2K</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">TANK-binding kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TBK1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03009747">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637842.1">
        <property type="nucleotide sequence ID" value="XM_012782388.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637843.1">
        <property type="nucleotide sequence ID" value="XM_012782389.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HK56"/>
    <dbReference type="Ensembl" id="ENSMICT00000045324.2">
        <property type="protein sequence ID" value="ENSMICP00000025192.1"/>
        <property type="gene ID" value="ENSMICG00000029327.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880966"/>
    <dbReference type="CTD" id="29110"/>
    <dbReference type="GeneTree" id="ENSGT00950000182937"/>
    <dbReference type="OrthoDB" id="10013850at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051219">
        <property type="term" value="F:phosphoprotein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140896">
        <property type="term" value="P:cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044565">
        <property type="term" value="P:dendritic cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904515">
        <property type="term" value="P:positive regulation of TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904417">
        <property type="term" value="P:positive regulation of xenophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061470">
        <property type="term" value="P:T follicular helper cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13988">
        <property type="entry name" value="STKc_TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21954">
        <property type="entry name" value="TBK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17127">
        <property type="entry name" value="Ubl_TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000100">
        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.420:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000106">
        <property type="entry name" value="serine/threonine-protein kinase TBK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000112">
        <property type="entry name" value="TANK binding kinase TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041309">
        <property type="entry name" value="TBK1_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041087">
        <property type="entry name" value="TBK1_ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF14">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE TBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18394">
        <property type="entry name" value="TBK1_CCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18396">
        <property type="entry name" value="TBK1_ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="9"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="729" mass="83619" checksum="60BE9D05A37B84C1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HM94</accession>
    <name>A0A8B7HM94_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105881600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007127">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638749.1">
        <property type="nucleotide sequence ID" value="XM_012783295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HM94"/>
    <dbReference type="Ensembl" id="ENSMICT00000012233.3">
        <property type="protein sequence ID" value="ENSMICP00000011136.3"/>
        <property type="gene ID" value="ENSMICG00000012248.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881600"/>
    <dbReference type="KEGG" id="mmur:105881600"/>
    <dbReference type="GeneTree" id="ENSGT01050000244869"/>
    <dbReference type="OrthoDB" id="5975390at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:olfactory receptor activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd15228">
        <property type="entry name" value="7tmA_OR10D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011136.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="35352" checksum="3DDE7BF2A81360A5" modified="2022-01-19" version="1">MRNVSGVTEFILLGIPHTEGLETMLFVFFLSFYIFTLMGNLLILLAIVSSTRLHTPMYFFLCKLSVFDIFFPSVSSPKMLFYLSGNSRTISYAGCVSQLFFYHFLGCTECFLYTVMAYDRFVAICYPLRYTIIMSHRVCTILAMGTSFFGCIQATFLTTLTFQLPYCGPNEVDYYFCDIPVMLKLACADTSALEMVGFISVGLMPLSCFLLILTSYSRIVCSILQIRSAEGRRHAFSTCSAHLTAILLFYMPVVLIYLRPTPSPWLDATVQILNNLVTPMLNPLIYSLRNKEVKSSLRKVLYQLVFLPEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HSQ8</accession>
    <name>A0A8B7HSQ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Hyaluronan synthase 1</fullName>
            <ecNumber evidence="5">2.4.1.212</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Hyaluronate synthase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Hyaluronic acid synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">HAS1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-[hyaluronan](n) + UDP-alpha-D-glucuronate = [hyaluronan](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12585"/>
            <dbReference type="Rhea" id="RHEA-COMP:12587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132153"/>
            <dbReference type="ChEBI" id="CHEBI:132154"/>
            <dbReference type="EC" id="2.4.1.212"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-[hyaluronan](n) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20465"/>
            <dbReference type="Rhea" id="RHEA-COMP:12583"/>
            <dbReference type="Rhea" id="RHEA-COMP:12585"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132153"/>
            <dbReference type="ChEBI" id="CHEBI:132154"/>
            <dbReference type="EC" id="2.4.1.212"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; hyaluronan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NodC/HAS family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.212" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03026411">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641008.1">
        <property type="nucleotide sequence ID" value="XM_012785554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HSQ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000039287.2">
        <property type="protein sequence ID" value="ENSMICP00000018560.2"/>
        <property type="gene ID" value="ENSMICG00000035879.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105882864"/>
    <dbReference type="CTD" id="3036"/>
    <dbReference type="GeneTree" id="ENSGT00390000010337"/>
    <dbReference type="OrthoDB" id="9876900at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050501">
        <property type="term" value="F:hyaluronan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085029">
        <property type="term" value="P:extracellular matrix assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030213">
        <property type="term" value="P:hyaluronan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000108">
        <property type="entry name" value="hyaluronan synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913">
        <property type="entry name" value="HYALURONAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22913:SF4">
        <property type="entry name" value="HYALURONAN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018560.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="582" mass="65118" checksum="15346C6D19224495" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HXH0</accession>
    <name>A0A8B7HXH0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Nectin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Nectin cell adhesion molecule 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Poliovirus receptor-related protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">NECTIN3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="17">Cis- and trans-homodimer. Can form trans-heterodimers with NECTIN1, NECTIN2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between NECTIN1 and NECTIN3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with AFDN, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Postsynaptic cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nectin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642874.1">
        <property type="nucleotide sequence ID" value="XM_012787420.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HXH0"/>
    <dbReference type="Ensembl" id="ENSMICT00000073418.1">
        <property type="protein sequence ID" value="ENSMICP00000050839.1"/>
        <property type="gene ID" value="ENSMICG00000049065.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105883892"/>
    <dbReference type="KEGG" id="mmur:105883892"/>
    <dbReference type="CTD" id="25945"/>
    <dbReference type="GeneTree" id="ENSGT00940000156028"/>
    <dbReference type="OrthoDB" id="9442762at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043296">
        <property type="term" value="C:apical junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044291">
        <property type="term" value="C:cell-cell contact zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098631">
        <property type="term" value="F:cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090103">
        <property type="term" value="P:cochlea morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061951">
        <property type="term" value="P:establishment of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002089">
        <property type="term" value="P:lens morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902414">
        <property type="term" value="P:protein localization to cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150052">
        <property type="term" value="P:regulation of postsynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060042">
        <property type="term" value="P:retina morphogenesis in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:symbiont entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07704">
        <property type="entry name" value="IgC1_2_Nectin-3-4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05887">
        <property type="entry name" value="IgV_1_Nectin-3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000298">
        <property type="entry name" value="Nectin cell adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000378">
        <property type="entry name" value="Nectin cell adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000511">
        <property type="entry name" value="Nectin cell adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033320">
        <property type="entry name" value="IgC1_2_Nectin-3-4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033319">
        <property type="entry name" value="Nectin-3_IgV_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051427">
        <property type="entry name" value="Nectin/Nectin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277:SF12">
        <property type="entry name" value="NECTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23277">
        <property type="entry name" value="NECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="405"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="59"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="170"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="23">
        <location>
            <begin position="269"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00065327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="549" mass="60813" checksum="81E3CA67AF8EA467" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HYN1</accession>
    <name>A0A8B7HYN1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Myelin proteolipid protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lipophilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PLP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Myelin membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the myelin proteolipid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034290">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643351.1">
        <property type="nucleotide sequence ID" value="XM_012787897.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HYN1"/>
    <dbReference type="Ensembl" id="ENSMICT00000041107.2">
        <property type="protein sequence ID" value="ENSMICP00000029162.1"/>
        <property type="gene ID" value="ENSMICG00000003053.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884181"/>
    <dbReference type="KEGG" id="mmur:105884181"/>
    <dbReference type="CTD" id="5354"/>
    <dbReference type="GeneTree" id="ENSGT00390000006915"/>
    <dbReference type="OMA" id="AVCKTRE"/>
    <dbReference type="OrthoDB" id="9993736at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043209">
        <property type="term" value="C:myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019911">
        <property type="term" value="F:structural constituent of myelin sheath"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022010">
        <property type="term" value="P:central nervous system myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001614">
        <property type="entry name" value="Myelin_PLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018237">
        <property type="entry name" value="Myelin_PLP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683">
        <property type="entry name" value="MYELIN PROTEOLIPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11683:SF11">
        <property type="entry name" value="MYELIN PROTEOLIPID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01275">
        <property type="entry name" value="Myelin_PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00214">
        <property type="entry name" value="MYELINPLP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00002">
        <property type="entry name" value="PLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00575">
        <property type="entry name" value="MYELIN_PLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01004">
        <property type="entry name" value="MYELIN_PLP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="277" mass="30061" checksum="C49AE251712D3954" modified="2022-01-19" version="1">MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNFQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I525</accession>
    <name>A0A8B7I525_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Zinc finger protein 709</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105885537</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645979.1">
        <property type="nucleotide sequence ID" value="XM_012790525.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I525"/>
    <dbReference type="Ensembl" id="ENSMICT00000064316.1">
        <property type="protein sequence ID" value="ENSMICP00000041006.1"/>
        <property type="gene ID" value="ENSMICG00000044274.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105885537"/>
    <dbReference type="KEGG" id="mmur:105885537"/>
    <dbReference type="GeneTree" id="ENSGT00950000182755"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000052">
        <property type="entry name" value="zinc finger protein 546 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000156">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000292">
        <property type="entry name" value="zinc finger protein 619"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF67">
        <property type="entry name" value="ZINC FINGER PROTEIN 709-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="137"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="55408" checksum="B6D06DCF0F09C514" modified="2022-01-19" version="1">MESVTFEDVAVNFTQGEWALLNPSQKNLYKDVMRETLRNLSFVGIKWEDQDIEDRYRNPRRNLRHYMAERLRESKAERQGGETLSQIPKHVLHKKTPAVKACESSVCGEVVMGHSFHMRDHADHEPNEYQEFTEKPYTHSRCEKAFGDHHSFPTHQSPHTHARQKPYDCKECGKTFTSPKTLRTHMVTHTGDGPHKCKVCRKGFAYPSLLRIHERSHTGEKPYECKQCGKAFKYSYYIEIHKRIHTGEKPYKCKICGKAFIYPVQSHEKTHNRENLYECKQCGKAFSLTSLRRHMIMHTGEGRYKCKVCGKAFDYPSEVRIHERIHTGEKPYQCKQCGKAFSCSSTFRKHEQIHTGERPYKCTKCEKAFRSRSSVRNHEMTHTGKKPYECKECGKTFICATSLRRHVIMHTGNGAYKCKVCGKAFAFPSSFHRHERIHTGEKAYECKQCGKTFRRSGSFRIHKRKHTGEKLESCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I7Q1</accession>
    <name>A0A8B7I7Q1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Volume-regulated anion channel subunit LRRC8E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Leucine-rich repeat-containing protein 8E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LRRC8E</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2',3'-cGAMP(out) = 2',3'-cGAMP(in)</text>
            <dbReference type="Rhea" id="RHEA:66320"/>
            <dbReference type="ChEBI" id="CHEBI:143093"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:66321"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:66322"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>taurine(out) = taurine(in)</text>
            <dbReference type="Rhea" id="RHEA:66328"/>
            <dbReference type="ChEBI" id="CHEBI:507393"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LRRC8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646230.2">
        <property type="nucleotide sequence ID" value="XM_012790776.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646231.2">
        <property type="nucleotide sequence ID" value="XM_012790777.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646232.2">
        <property type="nucleotide sequence ID" value="XM_012790778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I7Q1"/>
    <dbReference type="Ensembl" id="ENSMICT00000009643.3">
        <property type="protein sequence ID" value="ENSMICP00000008775.3"/>
        <property type="gene ID" value="ENSMICG00000009651.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000049707.2">
        <property type="protein sequence ID" value="ENSMICP00000034791.2"/>
        <property type="gene ID" value="ENSMICG00000009651.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885652"/>
    <dbReference type="CTD" id="80131"/>
    <dbReference type="GeneTree" id="ENSGT00940000159311"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005225">
        <property type="term" value="F:volume-sensitive anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015810">
        <property type="term" value="P:aspartate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140361">
        <property type="term" value="P:cyclic-GMP-AMP transmembrane import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000747">
        <property type="entry name" value="volume-regulated anion channel subunit LRRC8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001071">
        <property type="entry name" value="volume-regulated anion channel subunit LRRC8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000907">
        <property type="entry name" value="Volume-regulated anion channel subunit LRRC8E isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050715">
        <property type="entry name" value="LRR-SigEffector_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021040">
        <property type="entry name" value="LRRC8_Pannexin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45752:SF8">
        <property type="entry name" value="VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12534">
        <property type="entry name" value="Pannexin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="13 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="LRRC8 pannexin-like TM region" evidence="25">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00043750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00044211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF12534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008775.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="795" mass="90205" checksum="4EA6373A76D53811" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I7U0</accession>
    <name>A0A8B7I7U0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CD82</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006186">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645834.1">
        <property type="nucleotide sequence ID" value="XM_012790380.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645841.1">
        <property type="nucleotide sequence ID" value="XM_012790387.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645849.1">
        <property type="nucleotide sequence ID" value="XM_012790395.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I7U0"/>
    <dbReference type="Ensembl" id="ENSMICT00000040107.2">
        <property type="protein sequence ID" value="ENSMICP00000039389.1"/>
        <property type="gene ID" value="ENSMICG00000010264.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885471"/>
    <dbReference type="KEGG" id="mmur:105885471"/>
    <dbReference type="CTD" id="3732"/>
    <dbReference type="GeneTree" id="ENSGT00940000158481"/>
    <dbReference type="OrthoDB" id="10016273at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03160">
        <property type="entry name" value="CD37_CD82_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000021">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF44">
        <property type="entry name" value="CD82 ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="267" mass="29463" checksum="3150A0105F3DB14F" modified="2022-01-19" version="1">MGSACIKVTKYFLFLFNLLFFILGAVILGFGVWILADRSSFISVLQTSSSSLSMGGYIFIGVGAVTMLMGFLGCIGAVNEVRCLLGLYFAFLLVILVVQVAAGILFYLNVGKLKQEMGSIVTELIRNYNSSREDSLQEAWDYVQAQVKCCGWVSFYNWTDNAELMSRAEVTYPCSCEDKGQEDDSLFPRKGFCEAPGNSTQSGNSPEDWPVYKEGCMEKVQAWLQENLGIILGVCGGVAVIELLGMLLSICLCRHVHAEDYSKVPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WNN2</accession>
    <name>A0A8B7WNN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Gamma-aminobutyric acid receptor subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">GABA(A) receptor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">GABRD</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heteropentamer, formed by a combination of alpha (GABRA1-6), beta (GABRB1-3), gamma (GABRG1-3), delta (GABRD), epsilon (GABRE), rho (GABRR1-3), pi (GABRP) and theta (GABRQ) chains, each subunit exhibiting distinct physiological and pharmacological properties.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002133">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136873.1">
        <property type="nucleotide sequence ID" value="XM_020281284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WNN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000017160.3">
        <property type="protein sequence ID" value="ENSMICP00000015631.3"/>
        <property type="gene ID" value="ENSMICG00000017160.3"/>
    </dbReference>
    <dbReference type="CTD" id="2563"/>
    <dbReference type="GeneTree" id="ENSGT00940000160122"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19055">
        <property type="entry name" value="LGIC_TM_GABAAR_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000015">
        <property type="entry name" value="Gamma-aminobutyric acid (GABA-A) receptor, subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000018">
        <property type="entry name" value="Gamma-aminobutyric acid (GABA-A) receptor, subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008098">
        <property type="entry name" value="GABAAd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01722">
        <property type="entry name" value="GABAARDELTA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044038293" description="Gamma-aminobutyric acid receptor subunit delta" evidence="20">
        <location>
            <begin position="25"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="45"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="255"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015631.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="451" mass="50710" checksum="B77AA186CA3F8EE9" modified="2022-01-19" version="1">MDALARLLPALLLLCARRPRGTRAMNDIGDYVGSNLEISWLPNLDGLMAGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDKQECMLDLESYGYSSEDIVYYWSESQEHIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFHLRRNRGVYIIQSYMPSILLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKQKAKVKVAKPRAEMDVRNAIVLFSLSAAGVTQELAVTRRQCRVPGNLMGSYRSVEVETGETKEGAARAGAQGGLCGRFKPIDADTIDIYSRVVFPAAFVAVNVIYWAAYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WTL0</accession>
    <name>A0A8B7WTL0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peroxisomal membrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PXMP2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024948">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138697.1">
        <property type="nucleotide sequence ID" value="XM_020283108.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WTL0"/>
    <dbReference type="Ensembl" id="ENSMICT00000065084.1">
        <property type="protein sequence ID" value="ENSMICP00000048285.1"/>
        <property type="gene ID" value="ENSMICG00000047764.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105861818"/>
    <dbReference type="KEGG" id="mmur:105861818"/>
    <dbReference type="CTD" id="5827"/>
    <dbReference type="GeneTree" id="ENSGT00940000161539"/>
    <dbReference type="OrthoDB" id="860at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="195" mass="22246" checksum="A0919DCC17560A7B" modified="2022-01-19" version="1">MAPAVSTLRAEAGVGALPRRALARYLLLLRLYPVLTKAATSGVLSALGNFLTQMIEKTRKKEKSTSLDVSGPLRYAVYGFFFTGPLSHYFYLFLEHWIPSEVPLAGVKRLLLDRLLFAPAFLLLFFLVMNFLEGQDRAAAVARVRTHFWPVLRMNWRVWTPVQFVNINYVPLQFRVLFANLVALFWYAYLASLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJ47</accession>
    <name>A0A8C5UJ47_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein Ke2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PFDN6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007295">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJ47"/>
    <dbReference type="Ensembl" id="ENSMICT00000000920.3">
        <property type="protein sequence ID" value="ENSMICP00000000830.2"/>
        <property type="gene ID" value="ENSMICG00000000922.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010512"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="2"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00077068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000830.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="103" mass="11406" checksum="404A86745CE50A9E" modified="2022-01-19" version="1">MAELIQKKLQGEVEKYQQLQKDLSKSMSGRQKLEAQLTENNIVKEELALLDGSNVVFKLLGPVLVRQELGEARATVGKRLEYITAEIFLGTVLALGDEPGSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5ULV7</accession>
    <name>A0A8C5ULV7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metallophosphoesterase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Post-GPI attachment to proteins factor 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MPPE1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Metallophosphoesterase that catalyzes the removal of a side-chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI-anchor protein intermediate. Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with GPI-anchor proteins (via the GPI portion). Interacts with TMED10.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. MPPE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023096">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5ULV7"/>
    <dbReference type="Ensembl" id="ENSMICT00000001933.3">
        <property type="protein sequence ID" value="ENSMICP00000001764.2"/>
        <property type="gene ID" value="ENSMICG00000001930.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013236"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08165">
        <property type="entry name" value="MPP_MPPE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039541">
        <property type="entry name" value="MPP_MPPE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF0">
        <property type="entry name" value="METALLOPHOSPHOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="16">
        <location>
            <begin position="12"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001764.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="237" mass="27136" checksum="8B98947E097232C8" modified="2022-01-19" version="1">MERAFQTALWLLKPDVVFILGDVFDEGKWSSPQAWADDVERFQKMFRHPSHVQLKVVVGNHDIGFHYEMTTYKVKRFKKVFNPERLFSWKGVNFVMVNSVTMEGDRCTLCSKEEAELLAISHRLNCSWEVGCGAGRPLPASAPVLLQHYPLYRRSDSNCSGEDAAPPDERSTPFQERYDVLSREASQKLLWWLRPRLVLSGHTHSGCEVLHAGGPPELSVPSFSWRNRNNPSFIMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM19</accession>
    <name>A0A8C5UM19_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Photoreceptor cilium actin regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PCARE</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5URJ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000002547.3">
        <property type="protein sequence ID" value="ENSMICP00000002324.3"/>
        <property type="gene ID" value="ENSMICG00000002552.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161876"/>
    <dbReference type="OMA" id="CTVAHFC"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01327">
        <property type="entry name" value="KAZAL_PSTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050159">
        <property type="entry name" value="Kazal-type_SerProtInhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47499:SF1">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47499">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00282">
        <property type="entry name" value="KAZAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034797851" evidence="4">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002324.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="85" mass="9287" checksum="118F789013D2F2C2" modified="2022-01-19" version="1">MKILVGLLLLCTVTHFCSSSEAANLPLTTVDCSIYKKYPVAVIPCPITYLPVCGSDYITYGNECLLCSESLKSHGRVQFLHEGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UU73</accession>
    <name>A0A8C5UU73_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021395">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UU73"/>
    <dbReference type="Ensembl" id="ENSMICT00000002701.3">
        <property type="protein sequence ID" value="ENSMICP00000002459.2"/>
        <property type="gene ID" value="ENSMICG00000002705.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007084"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF18">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002459.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="145" mass="15731" checksum="DAEA2C6EEA77B56F" modified="2022-01-19" version="1">MAKSKNHTTHNQSQKWHRNGVDPKFPRNMCFAKKYNEKGLKKMQGNNTKAMSARAEAIKALVKPKEVKAKIPKGRSCKLSRLAYIAHPKLGKRACARIAKGLRLCKPKAENQTKAHSTASAAAPASVPAPAQAPKSAQAPTKAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVB1</accession>
    <name>A0A8C5UVB1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Beta-centractin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Actin-related protein 1B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ACTR1B</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642410.1">
        <property type="nucleotide sequence ID" value="XM_012786956.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVB1"/>
    <dbReference type="Ensembl" id="ENSMICT00000007411.3">
        <property type="protein sequence ID" value="ENSMICP00000006743.2"/>
        <property type="gene ID" value="ENSMICG00000007406.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883658"/>
    <dbReference type="KEGG" id="mmur:105883658"/>
    <dbReference type="CTD" id="10120"/>
    <dbReference type="GeneTree" id="ENSGT00940000161587"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000205">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000008">
        <property type="entry name" value="alpha-centractin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0944">Nitration</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00058335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006743.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="376" mass="42277" checksum="D1C3FCCD573631D7" modified="2022-01-19" version="1">MESYDIIANQPVVIDNGSGVIKAGFAGDQIPKYCFPNYVGRPKHMRVMAGALEGDLFIGPKAEEHRGLLAIRYPMEHGVVRDWNDMERIWQYVYSKDQLQTFSEEHPVLLTEAPLNPSKNREKAAEVFFETFNVPALFISMQAVLSLYATGRTTGVVLDSGDGVTHAVPIYEGFAMPHSIMRVDIAGRDVSRYLRLLLRKEGVDFHTSAEFEVVRTIKERACYLSINPQKDEALETEKVQYTLPDGSTLDVGPARFRAPELLFQPDLVGEESEGLHEVLAFAIHKSDMDLRRTLFANIVLSGGSTLFKGFGDRLLSEVKKLAPKDVKIKISAPQERLYSTWIGGSILASLDTFKKMWVSKKEYEEDGSRAIHRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1B7</accession>
    <name>A0A8C5V1B7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 157</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FAM174A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM174 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016842">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629040.1">
        <property type="nucleotide sequence ID" value="XM_012773586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1B7"/>
    <dbReference type="Ensembl" id="ENSMICT00000012294.3">
        <property type="protein sequence ID" value="ENSMICP00000011194.2"/>
        <property type="gene ID" value="ENSMICG00000012302.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876034"/>
    <dbReference type="KEGG" id="mmur:105876034"/>
    <dbReference type="CTD" id="345757"/>
    <dbReference type="GeneTree" id="ENSGT00730000111385"/>
    <dbReference type="OrthoDB" id="5917722at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009565">
        <property type="entry name" value="FAM174-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28607:SF1">
        <property type="entry name" value="MEMBRANE PROTEIN FAM174A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06679">
        <property type="entry name" value="DUF1180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149947" description="Transmembrane protein 157" evidence="11">
        <location>
            <begin position="28"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="190" mass="19852" checksum="34FBE568BDB7A0BB" modified="2022-01-19" version="1">MKAPHCCCCLIHFLAPVFLLLLLPGLSGPLVVLLQAADTEPGPGPPDPGSRTLPPLPPGPTAAQQPGPASAEAAGPRGSEAGNGSSPGAGLTADDNGGKAMEGLLGGGLAVSPSLGDKPMTQRALTVLMVVSGAVLVYFVVRTVRMRRRNRKTRRYGVLDTNIENMELTPLEQDDEDDDNTLFDANHPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1Y6</accession>
    <name>A0A8C5V1Y6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Macrosialin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CD68</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Lysosome membrane</location>
            <topology evidence="2 16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the LAMP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020552">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631652.1">
        <property type="nucleotide sequence ID" value="XM_012776198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1Y6"/>
    <dbReference type="Ensembl" id="ENSMICT00000014764.3">
        <property type="protein sequence ID" value="ENSMICP00000013464.3"/>
        <property type="gene ID" value="ENSMICG00000014773.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877543"/>
    <dbReference type="KEGG" id="mmur:105877543"/>
    <dbReference type="CTD" id="968"/>
    <dbReference type="GeneTree" id="ENSGT00940000164775"/>
    <dbReference type="OrthoDB" id="9428839at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072594">
        <property type="term" value="P:establishment of protein localization to organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.110:FF:000007">
        <property type="entry name" value="CD68 molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048528">
        <property type="entry name" value="Lamp2-like_luminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002000">
        <property type="entry name" value="Lysosome-assoc_membr_glycop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506">
        <property type="entry name" value="LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11506:SF2">
        <property type="entry name" value="MACROSIALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01299">
        <property type="entry name" value="Lamp2-like_luminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00336">
        <property type="entry name" value="LYSASSOCTDMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51407">
        <property type="entry name" value="LAMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 16 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149951" description="Macrosialin" evidence="19">
        <location>
            <begin position="22"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosome-associated membrane glycoprotein 2-like luminal" evidence="20">
        <location>
            <begin position="162"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="283"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013464.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="360" mass="38027" checksum="9EDD6391F7739E32" modified="2022-01-19" version="1">MRLAVIFSGALLGLLAAQGTGNDHPHKKSATLLPSFTVTPTATESTTSPGTTSHRTTKSHKTTTHRTTTTGTTQGPTTATHNPATTTSHGNVTVYPTSNSTATSQGPSTATHNPATTTTGHGNATVHPTSNSTSTSPGLSTSSPQPGPPPPPPSPSPGSQEAIGNYTWTNGSQPCVQLHAQIQIRVLYPTQSGTEAWGISVLNPNKTKAKGACEGPNPHLLLSFPYGQLSFGFQQDPQQNTVYLSYMAVEYNVSFPKAAQWTFSAQNSSLRDLQAPLGWSFSCRNSSIMLSPAFHLDLLSLRLQAAQLPHTGVFGPSFSCPSDRSILLPLIIGLILLGLLALVLVAFCIVRRRPPTYQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3A1</accession>
    <name>A0A8C5V3A1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03012388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012390">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3A1"/>
    <dbReference type="Ensembl" id="ENSMICT00000009812.3">
        <property type="protein sequence ID" value="ENSMICP00000008934.2"/>
        <property type="gene ID" value="ENSMICG00000009824.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00740000115534"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="10"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008934.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="128" mass="14528" checksum="38AD6A3F16D4679B" modified="2022-01-19" version="1">MFFCIGVKVPRNFRLLEELEEGQKGVGDGTVSWGLEDDEDMTLTRWTGMIIGPPRTNYENRIYSLKVECGSKYPEAPPSVRFVTKINMNGINNSSGMVSYSHFCSAKWQFSIAIKVLPQHQKAQTYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3W6</accession>
    <name>A0A8C5V3W6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">PR domain zinc finger protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 16">PR domain-containing protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PRDM12</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 16">Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors. Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates. Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15 16">Interacts with EHMT2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the class V-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014939">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609963.1">
        <property type="nucleotide sequence ID" value="XM_012754509.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3W6"/>
    <dbReference type="Ensembl" id="ENSMICT00000015479.3">
        <property type="protein sequence ID" value="ENSMICP00000014107.3"/>
        <property type="gene ID" value="ENSMICG00000015480.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865707"/>
    <dbReference type="KEGG" id="mmur:105865707"/>
    <dbReference type="CTD" id="59335"/>
    <dbReference type="GeneTree" id="ENSGT00940000161616"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140713">
        <property type="term" value="F:histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990226">
        <property type="term" value="F:histone methyltransferase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050965">
        <property type="term" value="P:detection of temperature stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048665">
        <property type="term" value="P:neuron fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19196">
        <property type="entry name" value="PR-SET_PRDM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000018">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000501">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000526">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001416">
        <property type="entry name" value="PR domain zinc finger protein 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044406">
        <property type="entry name" value="PRDM12_PR/SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017126">
        <property type="entry name" value="Znf_PRDM12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF20">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037163">
        <property type="entry name" value="PRDM12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0010">Activator</keyword>
    <keyword evidence="8 16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 16" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="86"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079747"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093312"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014107.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="362" mass="40293" checksum="E3083C3C44C13F85" modified="2022-01-19" version="1">MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLFEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPAEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEEQKKNKHEDFHPADSAAGTAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSAALQAHSPALPARHPHAPALAARAAAAHHLPAMWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V544</accession>
    <name>A0A8C5V544_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5'-nucleotidase domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NT5DC4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'(3')-deoxyribonucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V544"/>
    <dbReference type="Ensembl" id="ENSMICT00000013307.3">
        <property type="protein sequence ID" value="ENSMICP00000012134.3"/>
        <property type="gene ID" value="ENSMICG00000013300.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162631"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046054">
        <property type="term" value="P:dGMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046037">
        <property type="term" value="P:GMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07522">
        <property type="entry name" value="HAD_cN-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000021">
        <property type="entry name" value="NT5C2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008380">
        <property type="entry name" value="HAD-SF_hydro_IG_5-nucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016695">
        <property type="entry name" value="Pur_nucleotidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02244">
        <property type="entry name" value="HAD-IG-Ncltidse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12103:SF18">
        <property type="entry name" value="5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05761">
        <property type="entry name" value="5_nucleotid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017434">
        <property type="entry name" value="Purine_5'-nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012134.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="429" mass="48384" checksum="74CA54A159095EAE" modified="2022-01-19" version="1">GPAGIFVNRSLALGKIRCFGFDMDYTLAAYKSPAYEALAFELLLERLVCIGYPHEILRYTYDPAFPTRGLVFDALYGNLLKVDAHGNVLLGAHGFTFLSEAEIWSFYPSKFIQRDDLQRFHVLNTLFNLPETYLYACLVDFFSGCSRYTNCDTGYQHGNLFMSFRSLFQDVTEAMNNIHQSGCLKEKTLENLEKYVEKDARIPVLLGKMKEVGKVFLATNSSYDYTDAIMTYLFGVSEAAAPARPWRSFFDLIVVDTQKPRFFAEGTVLRQVNTDSGKLRVGTYTGPHQHCAVYSGGSSDVVCELLGVRGKDILYIGDHIFGDILKSKKRQGWRTCLVVPELSWELDIWAREKERLERLKRLDTCLADLYQHMDGSSRGLQVISSTKTEIQMPHESVVEQERASLATTACPLPCSQTSLLIKSCLSSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5C6</accession>
    <name>A0A8C5V5C6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PIK3C2B</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18373"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57658"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:18374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029884">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000016949.3">
        <property type="protein sequence ID" value="ENSMICP00000015446.3"/>
        <property type="gene ID" value="ENSMICG00000016940.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158263"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005942">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035005">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905037">
        <property type="term" value="P:autophagosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04012">
        <property type="entry name" value="C2A_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08381">
        <property type="entry name" value="C2B_PI3K_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00869">
        <property type="entry name" value="PI3Ka_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07290">
        <property type="entry name" value="PX_PI3K_C2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000006">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000005">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000036">
        <property type="entry name" value="phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000065">
        <property type="entry name" value="phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000105">
        <property type="entry name" value="phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000001">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000341">
        <property type="entry name" value="PI3K_Ras-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042134">
        <property type="entry name" value="PX_PI3K_C2_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF30">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00794">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00144">
        <property type="entry name" value="PI3K_rbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51546">
        <property type="entry name" value="PI3K_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K-RBD" evidence="14">
        <location>
            <begin position="377"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="C2 PI3K-type" evidence="15">
        <location>
            <begin position="627"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="13">
        <location>
            <begin position="789"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1042"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="1207"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="1322"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1461"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015446.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1591" mass="178743" checksum="661FB648E6378940" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5K1</accession>
    <name>A0A8C5V5K1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">Myoglobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MB</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 16">Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Fe(III)-heme b-[protein] + nitric oxide + H2O = Fe(II)-heme b-[protein] + nitrite + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:77711"/>
            <dbReference type="Rhea" id="RHEA-COMP:18975"/>
            <dbReference type="Rhea" id="RHEA-COMP:18976"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:77713"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
            <location evidence="12">Sarcoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the globin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642551.1">
        <property type="nucleotide sequence ID" value="XM_012787097.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5K1"/>
    <dbReference type="SMR" id="A0A8C5V5K1"/>
    <dbReference type="Ensembl" id="ENSMICT00000014099.3">
        <property type="protein sequence ID" value="ENSMICP00000012854.1"/>
        <property type="gene ID" value="ENSMICG00000014107.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883702"/>
    <dbReference type="KEGG" id="mmur:105883702"/>
    <dbReference type="CTD" id="4151"/>
    <dbReference type="GeneTree" id="ENSGT00940000160809"/>
    <dbReference type="OMA" id="VIIRMFQ"/>
    <dbReference type="OrthoDB" id="6344802at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016528">
        <property type="term" value="C:sarcoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098809">
        <property type="term" value="F:nitrite reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005344">
        <property type="term" value="F:oxygen carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08926">
        <property type="entry name" value="Mb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002335">
        <property type="entry name" value="Myoglobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47132">
        <property type="entry name" value="MYOGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47132:SF1">
        <property type="entry name" value="MYOGLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00613">
        <property type="entry name" value="MYOGLOBIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="9 16" id="KW-0408">Iron</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 15" id="KW-0561">Oxygen transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU251113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="154" mass="17081" checksum="85A5B35E59971359" modified="2022-01-19" version="1">MGLSDGEWQLVLNVWGKVEADVSGHGQEVLIRLFTGHPETLEKFDKFKHLKTADEMKASEDLKKHGTTVLTALGAILKKKGQHEAELKPLAQSHATKHKIPVKYLEFISDAIIHVLQSKHPADFGADAQGAMKKALELFRNDIAAKYKELGFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5N2</accession>
    <name>A0A8C5V5N2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cryptochrome-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CRY2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5N2"/>
    <dbReference type="Ensembl" id="ENSMICT00000014177.3">
        <property type="protein sequence ID" value="ENSMICP00000012925.3"/>
        <property type="gene ID" value="ENSMICG00000014177.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159073"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990512">
        <property type="term" value="C:Cry-Per complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042754">
        <property type="term" value="P:negative regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000850">
        <property type="term" value="P:negative regulation of glucocorticoid secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000323">
        <property type="term" value="P:negative regulation of nuclear receptor-mediated glucocorticoid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000118">
        <property type="term" value="P:regulation of sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014823">
        <property type="term" value="P:response to activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.579.10:FF:000001">
        <property type="entry name" value="Cryptochrome 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000001">
        <property type="entry name" value="Cryptochrome circadian regulator 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.80:FF:000003">
        <property type="entry name" value="cryptochrome-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF15">
        <property type="entry name" value="CRYPTOCHROME-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="12" id="KW-0157">Chromophore</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0274">FAD</keyword>
    <keyword evidence="9 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Photolyase/cryptochrome alpha/beta" evidence="22">
        <location>
            <begin position="30"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="539"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="316"/>
            <end position="323"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="20">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="20">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="20">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012925.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="601" mass="67978" checksum="50F3AF683AED7B6F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7L8</accession>
    <name>A0A8C5V7L8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DDX3X</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ABDC03036444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637291.1">
        <property type="nucleotide sequence ID" value="XM_012781837.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7L8"/>
    <dbReference type="Ensembl" id="ENSMICT00000041694.2">
        <property type="protein sequence ID" value="ENSMICP00000016754.1"/>
        <property type="gene ID" value="ENSMICG00000032772.2"/>
    </dbReference>
    <dbReference type="CTD" id="1654"/>
    <dbReference type="GeneTree" id="ENSGT00940000154443"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031252">
        <property type="term" value="C:cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043273">
        <property type="term" value="F:CTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008190">
        <property type="term" value="F:eukaryotic initiation factor 4E binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035613">
        <property type="term" value="F:RNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033592">
        <property type="term" value="F:RNA strand annealing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071243">
        <property type="term" value="P:cellular response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008625">
        <property type="term" value="P:extrinsic apoptotic signaling pathway via death domain receptors"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097193">
        <property type="term" value="P:intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901223">
        <property type="term" value="P:negative regulation of non-canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031333">
        <property type="term" value="P:negative regulation of protein-containing complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070131">
        <property type="term" value="P:positive regulation of mitochondrial translation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902523">
        <property type="term" value="P:positive regulation of protein K63-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034157">
        <property type="term" value="P:positive regulation of toll-like receptor 7 signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034161">
        <property type="term" value="P:positive regulation of toll-like receptor 8 signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036493">
        <property type="term" value="P:positive regulation of translation in response to endoplasmic reticulum stress"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045070">
        <property type="term" value="P:positive regulation of viral genome replication"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903608">
        <property type="term" value="P:protein localization to cytoplasmic stress granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18051">
        <property type="entry name" value="DEADc_DDX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="211"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="414"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="581"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="623"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="662" mass="73291" checksum="F45654BB0811094B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V8U5</accession>
    <name>A0A8C5V8U5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC105876694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010257">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V8U5"/>
    <dbReference type="Ensembl" id="ENSMICT00000034689.2">
        <property type="protein sequence ID" value="ENSMICP00000017629.1"/>
        <property type="gene ID" value="ENSMICG00000037516.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009819"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2650:FF:000001">
        <property type="entry name" value="40S ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="242" mass="27748" checksum="0E1DD884588DF515" modified="2022-01-19" version="1">MKLNISFPATGCQKLIEVDDERKLRTFYEKRLATEVAADGYVVRISGGNDKQGFPVTQGVLPHGRVLLLLSKGHSCYRPRRTGERKCKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEDKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDX1</accession>
    <name>A0A8C5VDX1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytosolic iron-sulfur assembly component 2A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">MIP18 family protein FAM96A</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer. Component of the CIA complex. Interacts with CIAO1. Interacts with IREB2. Interacts with APAF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDX1"/>
    <dbReference type="Ensembl" id="ENSMICT00000051926.2">
        <property type="protein sequence ID" value="ENSMICP00000019126.2"/>
        <property type="gene ID" value="ENSMICG00000011072.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017697"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.130:FF:000004">
        <property type="entry name" value="cytosolic iron-sulfur assembly component 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF2">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00082916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019126.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="164" mass="18695" checksum="23DE7BF11B016683" modified="2022-01-19" version="1">MGQVSGLLSWTRSRVLQLSGFSEPGAIMERKALEIYDLIRTIWDPEKPHTLEELEVATESCVEVEEINEDDYLVIIKFMPIVPHCSLATLIGLCLRRFLTFKHKLEISISEETHSTEEDINQVSGNCDNPNLQEIVEQCVLEPDSYSKSHQTVIDKFILTVCIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VGK4</accession>
    <name>A0A8C5VGK4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A</fullName>
            <ecNumber evidence="4">3.1.4.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PDE8A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with RAF1. The interaction promotes RAF1 activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.53" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03013889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VGK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000035480.2">
        <property type="protein sequence ID" value="ENSMICP00000022721.2"/>
        <property type="gene ID" value="ENSMICG00000000779.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156422"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000002">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000040">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000209">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057304">
        <property type="entry name" value="PDE8-like_REC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23198">
        <property type="entry name" value="PDE8A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0114">cAMP</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="141"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="17">
        <location>
            <begin position="408"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="484"/>
            <end position="488"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022721.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="757" mass="85679" checksum="3D8CCD8F28C79EFA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VH87</accession>
    <name>A0A8C5VH87_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
            <ecNumber evidence="5">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">4'-phosphopantetheinyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">AASDHPPT</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>apo-[ACP] + CoA = holo-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:12069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>apo-[ACP] + acetyl-CoA = acetyl-[ACP] + adenosine 3',5'-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46564"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46565"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03006793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604208.1">
        <property type="nucleotide sequence ID" value="XM_012748754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VH87"/>
    <dbReference type="Ensembl" id="ENSMICT00000037057.2">
        <property type="protein sequence ID" value="ENSMICP00000022327.1"/>
        <property type="gene ID" value="ENSMICG00000032630.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105862470"/>
    <dbReference type="KEGG" id="mmur:105862470"/>
    <dbReference type="CTD" id="60496"/>
    <dbReference type="GeneTree" id="ENSGT00390000004663"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000006">
        <property type="entry name" value="L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="16">
        <location>
            <begin position="125"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="309" mass="35727" checksum="FBAE09F988DAF1A0" modified="2022-01-19" version="1">MVFPAKRLCLVPSMEGVRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNNIRLQRTAKGKPVLAKDSLNPYPNFNFNISHQGDFAVLAAEPELQVGIDIMKTSFPGRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDISPLNLDIGQVYRETRLFLDGEEEKEWIFEESKIDEHHFVAVALRKPDGSRHQEVPSQDDSKPSQRKFTILTFNDLIASAVPMTPEDPSFWDCFCFTEEILIRNGGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VIV7</accession>
    <name>A0A8C5VIV7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 variant 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LOC105875108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VIV7"/>
    <dbReference type="Ensembl" id="ENSMICT00000030726.2">
        <property type="protein sequence ID" value="ENSMICP00000023795.1"/>
        <property type="gene ID" value="ENSMICG00000034139.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158854"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13909" checksum="034EFDDE95F4F7B4" modified="2022-01-19" version="1">MPATTDSGVKVPHNFQLLEELEEAQKGVGDAIVSWGLDDDKDMTLTRWTGMIIGTPPLFVRFVTKINMNGVHSSNGVVDPRAISVLAKWQNSYNIKVVLQELQCLMMSKENMKLAQLPKGQCYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLX3</accession>
    <name>A0A8C5VLX3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PML-RARA-regulated adapter molecule 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRAM1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with SKAP2, LCP2 and DBNL. May interact with LYN. Interacts with NEK6.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLX3"/>
    <dbReference type="Ensembl" id="ENSMICT00000037204.2">
        <property type="protein sequence ID" value="ENSMICP00000024991.1"/>
        <property type="gene ID" value="ENSMICG00000038402.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063460"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043313">
        <property type="term" value="P:regulation of neutrophil degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000179">
        <property type="entry name" value="PML-RARA regulated adaptor molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043443">
        <property type="entry name" value="FYB1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029294">
        <property type="entry name" value="hSH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16830:SF11">
        <property type="entry name" value="PML-RARA-REGULATED ADAPTER MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16830">
        <property type="entry name" value="SH2 CONTAINING ADAPTOR PRAM-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14603">
        <property type="entry name" value="hSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="606"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00063710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00074948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024991.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="705" mass="78150" checksum="990829E1D0682F40" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM72</accession>
    <name>A0A8C5VM72_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytoplasmic polyadenylation element-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CPEB1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Interacts with kinesin, dynein, APLP1, APLP2, TENT2/GLD2 and APP. Both phosphorylated and non phosphorylated forms interact with APLP1. Interacts with TENT4B; the interaction is required for TENT4B-mediated translational control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Postsynaptic density</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CPEB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013891">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM72"/>
    <dbReference type="Ensembl" id="ENSMICT00000042086.2">
        <property type="protein sequence ID" value="ENSMICP00000025915.2"/>
        <property type="gene ID" value="ENSMICG00000026395.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155524"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000900">
        <property type="term" value="F:mRNA regulatory element binding translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008135">
        <property type="term" value="F:translation factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000766">
        <property type="term" value="P:negative regulation of cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12723">
        <property type="entry name" value="RRM1_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12725">
        <property type="entry name" value="RRM2_CPEB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000054">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000086">
        <property type="entry name" value="Putative Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.40:FF:000002">
        <property type="entry name" value="Putative Cytoplasmic polyadenylation element-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.40">
        <property type="entry name" value="Cytoplasmic polyadenylation element-binding protein, ZZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032292">
        <property type="entry name" value="CEBP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032296">
        <property type="entry name" value="CEBP_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038446">
        <property type="entry name" value="CEBP_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034819">
        <property type="entry name" value="CPEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034977">
        <property type="entry name" value="CPEB1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT BINDING PROTEIN CPEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12566:SF9">
        <property type="entry name" value="CYTOPLASMIC POLYADENYLATION ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16368">
        <property type="entry name" value="CEBP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16366">
        <property type="entry name" value="CEBP_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16367">
        <property type="entry name" value="RRM_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="338"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="452"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="186"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025915.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="588" mass="64803" checksum="9B323BBAEB917C25" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNM3</accession>
    <name>A0A8C5VNM3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RPS2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Interacts with zinc finger protein ZNF277 (via zinc-finger domains); the interaction is direct; the interaction is extra-ribosomal. Interaction with ZNF277 competes with the binding of RPS2 to protein arginine methyltransferase PRMT3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020800">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNM3"/>
    <dbReference type="Ensembl" id="ENSMICT00000042843.2">
        <property type="protein sequence ID" value="ENSMICP00000025932.1"/>
        <property type="gene ID" value="ENSMICG00000012765.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153095"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000133">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="72"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="210" mass="21712" checksum="07CA68A8AD15A741" modified="2022-01-19" version="1">MADDAGAAGGPGGPGGPGMGGRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFGHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNT6</accession>
    <name>A0A8C5VNT6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">V-ATPase 69 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Vacuolar proton pump subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC105859570</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4. Interacts with WFS1. Interacts with alpha-crystallin B chain/CRYAB and with MTOR, forming a ternary complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">Clathrin-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03020820">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNT6"/>
    <dbReference type="Ensembl" id="ENSMICT00000032297.2">
        <property type="protein sequence ID" value="ENSMICP00000023422.2"/>
        <property type="gene ID" value="ENSMICG00000028894.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074787"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF9">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="18">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="19">
        <location>
            <begin position="119"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="17">
        <location>
            <begin position="225"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023422.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="521" mass="57172" checksum="F85591BD1FA4C87A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VRP2</accession>
    <name>A0A8C5VRP2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Monocarboxylate transporter 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 16 member 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SLC16A11</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyruvate(out) + H(+)(out) = pyruvate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:64720"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with isoform 2 of BSG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRP2"/>
    <dbReference type="Ensembl" id="ENSMICT00000054744.2">
        <property type="protein sequence ID" value="ENSMICP00000028757.1"/>
        <property type="gene ID" value="ENSMICG00000005931.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162017"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000187">
        <property type="entry name" value="Solute carrier family 16 member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF80">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="250"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="18">
        <location>
            <begin position="14"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="442" mass="44495" checksum="DBD797D6EC6622D1" modified="2022-01-19" version="1">MTPRPAGPPDGGWGWVVAATGFAVNGLSYGLLRSLGLALPDLAEHFDRSAQETAWVSALALAVQQAASPVGSALSTRWGARPVVMVGGVLTSLGFVCSAFARSLAHVYLGLGLLAGSGWALAFAPALGTLSRYFSRRRVLAVGLALTGNGASSLLLAPALQFLLDTFGWRGALLLLGALTLHLTPCGALLRPLTLPGDPPAPPRGPLAALGLGLFTHRAFSVFALGTALVGGGYFVPYVHLAPHALDRGLAGYGAALVVAVAAVGDAGARLVCGWLADQGWVPLPRLLAVFGALTGLGLLVVGLGGWGGPLLAAAGAYGLSAGSYAPLVFGVLPGLVGLGGVVQATGLVMMLMSLGGLLGPPLSGFLRDETGDFTASFLVCGSFILAGSFIYTGLPRALPSCRPASPPATPPPEMGELLPVPVPQVALLSPAGPRSTLDATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VUL1</accession>
    <name>A0A8C5VUL1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LIM domain binding 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LDB2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005454">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005455">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VUL1"/>
    <dbReference type="Ensembl" id="ENSMICT00000030302.2">
        <property type="protein sequence ID" value="ENSMICP00000027486.1"/>
        <property type="gene ID" value="ENSMICG00000000598.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005639"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029005">
        <property type="entry name" value="LIM-bd/SEUSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10378">
        <property type="entry name" value="LIM DOMAIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01803">
        <property type="entry name" value="LIM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="331" mass="37992" checksum="F1E5F330D385B3F8" modified="2022-01-19" version="1">MSSTPHDPFYSSPFGPFYRRHTPYMVQPEYRIYEMNKRLQSRTEDSDNLWWDAFATEFFEDDATLTLSFCLEDGPKRYTIGRTLIPRYFSTVFEGGVTDLYYILKHSKESYHNSSITVDCDQCTMVTQHGKPMFTKVCTEGRLILEFTFDDLMRIKTWHFTIRQYRELVPRSILAMHAQDPQVLDQLSKNITRMGLTNFTLNYLRLCVILEPMQELMSRHKTYNLSPRDCLKTCLFQKWQRMVAPPAEPTRQPTTKRRKRKNSTSSTSNSSAGTNANSTGSKKKTTAANLSLSSQVPGLGAIPNCSLNPGRDGDLCHSTAVTPSGQFKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VXS4</accession>
    <name>A0A8C5VXS4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 54</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM54 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029848">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VXS4"/>
    <dbReference type="Ensembl" id="ENSMICT00000045303.2">
        <property type="protein sequence ID" value="ENSMICP00000027469.2"/>
        <property type="gene ID" value="ENSMICG00000035663.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004700"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020977">
        <property type="entry name" value="Beta-casein-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258">
        <property type="entry name" value="KERATINOCYTE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31258:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12304">
        <property type="entry name" value="BCLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027469.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20899" checksum="7F787CA414921B6F" modified="2022-01-19" version="1">MCLCLGGLSVCDFWKVLMKTGLVLVVLGHVSFITAPLLHGTVLYYVGYCTVTILSVTSSIVVITSGIAAIMLSRHLPSTPLRWMVFNWSVACALLSLTCALVLLASIAVTFATQGQALPELLALTPDCPFDPISSVCLWAVTLVLCMVESVFAVRCTQLAHQLLEPSIHHVIPESPEPVGDQDLLSCTSSELLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYU6</accession>
    <name>A0A8C5VYU6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatosis and centriole associated 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPATC1L</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03033374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635520.1">
        <property type="nucleotide sequence ID" value="XM_012780066.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYU6"/>
    <dbReference type="Ensembl" id="ENSMICT00000052320.2">
        <property type="protein sequence ID" value="ENSMICP00000033316.2"/>
        <property type="gene ID" value="ENSMICG00000027207.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879669"/>
    <dbReference type="KEGG" id="mmur:105879669"/>
    <dbReference type="CTD" id="84221"/>
    <dbReference type="GeneTree" id="ENSGT00520000055666"/>
    <dbReference type="OrthoDB" id="6114770at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141163">
        <property type="term" value="P:positive regulation of cAMP/PKA signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010739">
        <property type="term" value="P:positive regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026715">
        <property type="entry name" value="SPATC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029384">
        <property type="entry name" value="Speriolin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029385">
        <property type="entry name" value="Speriolin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22192">
        <property type="entry name" value="SPERIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22192:SF1">
        <property type="entry name" value="SPERIOLIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15059">
        <property type="entry name" value="Speriolin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15058">
        <property type="entry name" value="Speriolin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Speriolin N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Speriolin C-terminal" evidence="2">
        <location>
            <begin position="198"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF15058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033316.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="343" mass="38143" checksum="32DCBD58EB5A62AF" modified="2022-01-19" version="1">MAERSELMSRLMSENADLKKQVRLLKENQMLKRLLNESCQESCGRAGRDLLFPKAPGYPEACSPASAVPDFGRFASVPDVPSQLQTSSLEDLLCSHAPLSSEDDSSPGCAVPSQAPFKAFLSPQELRTPRDNDGMLSPLLSPLQNSLGDKAMLEPRGTARPKKVCFSESSLPTGDRPRRSYYLSEIQSFAGTEKDGRIVGEIAFQLDRRILAYVFPGVTRLYGFTVSNIPEKIKQTSIKSLDGSVDEKKLRELTHRYLTLTARLEKLGYSRDVHPVFSEFLINTYGILKQRPDLRANPLHSSPAALRKLVIDIVPPKFLGDSLLLLNCLCELSKEDSKPLFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZY4</accession>
    <name>A0A8C5VZY4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Myosin XVB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MYO15B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019879">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000029673.2">
        <property type="protein sequence ID" value="ENSMICP00000030730.2"/>
        <property type="gene ID" value="ENSMICG00000043633.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00930000151032"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.530">
        <property type="entry name" value="MyTH4 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059004">
        <property type="entry name" value="MYO15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000857">
        <property type="entry name" value="MyTH4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038185">
        <property type="entry name" value="MyTH4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051567">
        <property type="entry name" value="Unconventional_Myosin_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692">
        <property type="entry name" value="MYOSIN VII, XV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22692:SF16">
        <property type="entry name" value="MYOSIN XVB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26570">
        <property type="entry name" value="MYO15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00784">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00139">
        <property type="entry name" value="MyTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51016">
        <property type="entry name" value="MYTH4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="627"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="13">
        <location>
            <begin position="1432"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="domain" description="MyTH4" evidence="13">
        <location>
            <begin position="2510"/>
            <end position="2657"/>
        </location>
    </feature>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="2635"/>
            <end position="2960"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
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        <location>
            <begin position="570"/>
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        <location>
            <begin position="1116"/>
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            <begin position="1831"/>
            <end position="1939"/>
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            <begin position="1955"/>
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            <begin position="2414"/>
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            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
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            <begin position="33"/>
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            <begin position="237"/>
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    </feature>
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            <begin position="412"/>
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            <begin position="487"/>
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    </feature>
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            <begin position="1831"/>
            <end position="1858"/>
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        <location>
            <begin position="1890"/>
            <end position="1904"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1986"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="2046"/>
            <end position="2055"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2069"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="2116"/>
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    </feature>
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    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="652"/>
            <end position="659"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50057"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51456"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030730.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2960" mass="320949" checksum="5E9075AFBD0EE55C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W5A8</accession>
    <name>A0A8C5W5A8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase 1 regulatory subunit 1B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DARPP-32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Dopamine- and cAMP-regulated neuronal phosphoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PPP1R1B</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibitor of protein-phosphatase 1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein phosphatase inhibitor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621358.1">
        <property type="nucleotide sequence ID" value="XM_012765904.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136559.1">
        <property type="nucleotide sequence ID" value="XM_020280970.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5A8"/>
    <dbReference type="Ensembl" id="ENSMICT00000029339.2">
        <property type="protein sequence ID" value="ENSMICP00000035358.1"/>
        <property type="gene ID" value="ENSMICG00000010515.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872106"/>
    <dbReference type="KEGG" id="mmur:105872106"/>
    <dbReference type="CTD" id="84152"/>
    <dbReference type="GeneTree" id="ENSGT00730000111283"/>
    <dbReference type="OrthoDB" id="9946890at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048148">
        <property type="term" value="P:behavioral response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071314">
        <property type="term" value="P:cellular response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007621">
        <property type="term" value="P:negative regulation of female receptivity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001975">
        <property type="term" value="P:response to amphetamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043278">
        <property type="term" value="P:response to morphine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008542">
        <property type="term" value="P:visual learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008466">
        <property type="entry name" value="PPP1R1A/B/C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417:SF2">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15417">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR AND DOPAMINE- AND CAMP-REGULATED NEURONAL PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05395">
        <property type="entry name" value="DARPP-32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="90"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="22909" checksum="79E792989FE5FA3D" modified="2022-01-19" version="1">MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPAMLFRLSEHSSPEEEASPHQRASGEGHHVKSKRSNPCAYTPPSLKAVQRIAESHLQSISNLNENPGSEEEDELGELRELGYPREEDEEEEDDDEEEEEEEDSQAEILKGSRVFAGQKTAYGQGLEGPWERPPPLDESQRDGSSEDQVEDPALSEPGEEPQRPAPPKPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAV1</accession>
    <name>A0A8C5WAV1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010676">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WAV1"/>
    <dbReference type="Ensembl" id="ENSMICT00000009624.3">
        <property type="protein sequence ID" value="ENSMICP00000037265.1"/>
        <property type="gene ID" value="ENSMICG00000009630.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000687"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="117"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="191" mass="21562" checksum="B95BEAD92645B68E" modified="2022-01-19" version="1">MSAAPARHPHGVKRPASPDDDLGSSNWEAADLDNEEKKQKFLRLMGAGKKEYTGRLVIGNHKTKIHEELESQYQQSRDSKLSGRYRRHHGLGFSEIDNHDEEGDVAGDVMMMMMMMMIPDDSESDSESEKEESAKELQAIEHPDQVEDPPKKDAKSNYKMTFVKSSGSLLETKTLHIPTTCPDLSYERKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XAP7</accession>
    <name>A0A8C5XAP7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Signal transducer and activator of transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">STAT2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009854">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5XAP7"/>
    <dbReference type="Ensembl" id="ENSMICT00000000091.3">
        <property type="protein sequence ID" value="ENSMICP00000000084.3"/>
        <property type="gene ID" value="ENSMICG00000000089.3"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0070721">
        <property type="term" value="C:ISGF3 complex"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007259">
        <property type="term" value="P:cell surface receptor signaling pathway via JAK-STAT"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0060339">
        <property type="term" value="P:negative regulation of type I interferon-mediated signaling pathway"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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    <dbReference type="GO" id="GO:0090140">
        <property type="term" value="P:regulation of mitochondrial fission"/>
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    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
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    </dbReference>
    <dbReference type="CDD" id="cd10373">
        <property type="entry name" value="SH2_STAT2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
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    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
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    </dbReference>
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        <property type="entry name" value="STAT transcription factor, DNA-binding domain"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.532.10">
        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
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    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022756">
        <property type="entry name" value="STAT2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035854">
        <property type="entry name" value="STAT2_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12188">
        <property type="entry name" value="STAT2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47655">
        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0010">Activator</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13 14" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="16">
        <location>
            <begin position="564"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="149"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000084.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="845" mass="97463" checksum="B8F9C62F4189052B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDE8</accession>
    <name>A0A8C5XDE8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ORM1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ORMDL2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Ceramide-sensitive subunit of the serine palmitoyltransferase (SPT) complex, which is also composed of SPTLC1, SPTLC2/3 and SPTSSA/B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ORM family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608517.1">
        <property type="nucleotide sequence ID" value="XM_012753063.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDE8"/>
    <dbReference type="SMR" id="A0A8C5XDE8"/>
    <dbReference type="Ensembl" id="ENSMICT00000010916.3">
        <property type="protein sequence ID" value="ENSMICP00000009944.1"/>
        <property type="gene ID" value="ENSMICG00000027741.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105864895"/>
    <dbReference type="KEGG" id="mmur:105864895"/>
    <dbReference type="CTD" id="29095"/>
    <dbReference type="GeneTree" id="ENSGT00950000183178"/>
    <dbReference type="OMA" id="STHYTHF"/>
    <dbReference type="OrthoDB" id="1932233at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000303">
        <property type="term" value="P:regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018147">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="153" mass="17361" checksum="2D6738AC34960969" modified="2022-01-19" version="1">MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYVFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRVFGINKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XP35</accession>
    <name>A0A8C5XP35_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">TBP-associated factor 8</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XP35"/>
    <dbReference type="Ensembl" id="ENSMICT00000053907.2">
        <property type="protein sequence ID" value="ENSMICP00000038495.2"/>
        <property type="gene ID" value="ENSMICG00000035609.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017567"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22918">
        <property type="entry name" value="HFD_TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037818">
        <property type="entry name" value="TAF8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46469:SF1">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="9">
        <location>
            <begin position="28"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038495.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="287" mass="32012" checksum="24B319C5117B7313" modified="2022-01-19" version="1">NLDSNMAGASGSGTRSGSKQTTNPVDNFHLARRRTLQVVVSSLLTEPGFESAEKASVETLTEMLQSYIPEIGRSAESHCEHTARTRPALSDIVVTLVEMGFNVDTLPAYPVTPKALTAGQNRPHPPHIPSHCPEFPDPHTYIGTPTYREPVSDSQVLREKAAPQRRHVQRALTRFMAKTGETQSLFKDDVSTLPSIAARPFGIPYLTALLPSELEMQQMEETDSSEQDEQTQRTSLFISVQRILEPRRRTLLSCSRTPPCREAESIIDNPYLRPVKKPKIRRKKSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XPP5</accession>
    <name>A0A8C5XPP5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat domain 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ANKRD7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03015317">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XPP5"/>
    <dbReference type="Ensembl" id="ENSMICT00000036420.2">
        <property type="protein sequence ID" value="ENSMICP00000039137.2"/>
        <property type="gene ID" value="ENSMICG00000036567.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161777"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050657">
        <property type="entry name" value="Ankyrin_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147:SF62">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039137.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="252" mass="28734" checksum="EB4D06DAA1BE9FB8" modified="2022-01-19" version="1">MKKLFCFRRRKGKPHNLPMGLGYDLRDKDLKKLHKAASVGDSEELRKYLQLKKLDVNMRDKEYRTPLHLACANGYMNIVCLLIEKQCEINVLDSENRSPLIKAVQCQREDCVTVLLSCGADPELVDFNHNTALHYAVCGQSVSLVEKLLKHKANLEAKNKDGYTPLLLAVSENNEEMVKFLLRKGADVNATDNNQRTALMIAISNEPTSLVNILLQQDLRNMLLLMVLLCKYYQLISNYGMKENSKQMNCTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQ24</accession>
    <name>A0A8C5XQ24_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine protease 42, pseudo</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PRSS42</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQ24"/>
    <dbReference type="Ensembl" id="ENSMICT00000048485.2">
        <property type="protein sequence ID" value="ENSMICP00000039191.2"/>
        <property type="gene ID" value="ENSMICG00000029208.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163134"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000006">
        <property type="entry name" value="Serine proteinase stubble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253:SF159">
        <property type="entry name" value="SERINE PROTEASE 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24253">
        <property type="entry name" value="TRANSMEMBRANE PROTEASE SERINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="77"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039191.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="289" mass="31506" checksum="74B2B77CD7725915" modified="2022-01-19" version="1">MGLSPGWGEGCLGAWEALPREVCSARRCPRVQQDVASFSAVYFPREALGAGETGPASLSSSSDTVLTPVCGRSFLKIVGGQDAEEGKWPWQVSVRIHGRHICGGSLVTSKWVVTAAHCIISRYHYSVKMGDRSILAENTSLVVPVKKIIVHPKFATFTTVEHDLAILQLVYSVNFTSNIQPICIPRETFQVESGTRCWVTGWGKTQEGGFPAKILQEVELSVIRKEKCNEMMQRILLSSREIIQKGMICGYGGKGKDSCQGDSGGPMACEYNDTWVQVGVVSWGMGCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQJ3</accession>
    <name>A0A8C5XQJ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cAMP-responsive element modulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CREM</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028413">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028414">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028416">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028418">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028419">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQJ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000053550.2">
        <property type="protein sequence ID" value="ENSMICP00000039476.2"/>
        <property type="gene ID" value="ENSMICG00000000835.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156952"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990589">
        <property type="term" value="C:ATF4-CREB1 transcription factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14690">
        <property type="entry name" value="bZIP_CREB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000003">
        <property type="entry name" value="cAMP-responsive element modulator isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003102">
        <property type="entry name" value="CREB1-like_pKID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001630">
        <property type="entry name" value="Leuzip_CREB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879:SF4">
        <property type="entry name" value="CAMP-RESPONSIVE ELEMENT MODULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45879">
        <property type="entry name" value="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02173">
        <property type="entry name" value="pKID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00041">
        <property type="entry name" value="LEUZIPPRCREB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="13">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039476.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="295" mass="32247" checksum="5569065904EC35FC" modified="2022-01-19" version="1">MSKCGRKKYIKTNLRQMTMETIESRQDGSVRDSVAESKSAHMQTQTGQNSIPTLAQVATIAETDESAESEGVIDSHKRREILSRRPSYRKKNEISSDVPGVPKIEEESEEEPPNIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQAATGDMPTYQIRAPTTALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XSQ5</accession>
    <name>A0A8C5XSQ5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSQ5"/>
    <dbReference type="Ensembl" id="ENSMICT00000066884.1">
        <property type="protein sequence ID" value="ENSMICP00000040537.1"/>
        <property type="gene ID" value="ENSMICG00000041618.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154039"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000365">
        <property type="entry name" value="If kappa light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="5">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="106" mass="11516" checksum="7ACC7C628F582FD4" modified="2022-01-19" version="1">DIVMTQTPLSLPVTPGEPASISCRSSQSLLHSNGKTYLHWYLQKPGQSPQLLIYLGFTRASGVPDRFSGSGSGTDFTLKISKVEAEDVGVYYCMQTIQLPPTVVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XT65</accession>
    <name>A0A8C5XT65_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105882985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 12">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. STT3A complex assembly occurs through the formation of 3 subcomplexes. Subcomplex 1 contains RPN1 and TMEM258, subcomplex 2 contains the STT3A-specific subunits STT3A, DC2/OSTC, and KCP2 as well as the core subunit OST4, and subcomplex 3 contains RPN2, DAD1, and OST48. The STT3A complex can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with TMEM35A/NACHO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endoplasmic reticulum membrane</location>
            <topology evidence="2 12">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the OST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03025537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025538">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025539">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XT65"/>
    <dbReference type="Ensembl" id="ENSMICT00000059676.1">
        <property type="protein sequence ID" value="ENSMICP00000040923.1"/>
        <property type="gene ID" value="ENSMICG00000044691.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009630"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="349" mass="39589" checksum="B641CF983471E49D" modified="2022-01-19" version="1">SRNVESYSRLGNPARSDDVLDYGPFRDVPAFSQAVLRAHFENNSPFLTVTGLARAIEVSHWGNVAVEETGSRRPTRRAVSVPQTILPAAAQDVYYRDEIGNVSTSHLHVLDDSVEMEIRPRFPLFGGWKTHYVIGYNLPSYEYLYCLGDQYALKMRFVDHVFDEQVIDSLTVKIILPEGAKNIQIDSPYDIVRAPDELHYTYLDTFGRPVIVAYKNNLVEQHIQDIVVHYTFNKVLMLQEPLLVVAAFYVLFFTVIVYVRLDFSITKDPAAEARMKVACITEQVLTLVNKRLGLYRHFEEAVNRYKQSRDAAALSGGRKSLEAEHKALTGEIAVLQSRLKAEGSDLCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XWS2</accession>
    <name>A0A8C5XWS2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018437">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XWS2"/>
    <dbReference type="Ensembl" id="ENSMICT00000066423.1">
        <property type="protein sequence ID" value="ENSMICP00000042294.1"/>
        <property type="gene ID" value="ENSMICG00000041621.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162547"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05385">
        <property type="entry name" value="CAP_GLIPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000008">
        <property type="entry name" value="GLI pathogenesis-related 1 (Glioma)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034121">
        <property type="entry name" value="SCP_GLIPR-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01010">
        <property type="entry name" value="CRISP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034465796" description="SCP domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="6">
        <location>
            <begin position="32"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="239" mass="26473" checksum="1CAC93D953EC5581" modified="2022-01-19" version="1">MALRRALSCLWTLGLCLAAGKSPVIPSIADPHFIDSCLRAHNQWRGRVEPPAADMKFMSWDAGLAKMAKAWANKCIFQHNSCLDQSYGCYAAFEYVGENIWLGGTRIFTPNAAITSWYNETEFYDFDSLSCSKVCGHYTQLVWAKSSNVGCAATMCPNLGGPSTAIFVCNYGPAGNFANMPPYTRGEPCSLCSAKERCITKLCSKQKGKKIIITLYLDSKVSRNSLSFQIYLLRFIIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXB4</accession>
    <name>A0A8C5XXB4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane and coiled-coil domains 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMCO5A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03004577">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXB4"/>
    <dbReference type="Ensembl" id="ENSMICT00000060668.1">
        <property type="protein sequence ID" value="ENSMICP00000042522.1"/>
        <property type="gene ID" value="ENSMICG00000044342.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153380"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026617">
        <property type="entry name" value="SMCO2/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22422:SF7">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22422">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 5B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14992">
        <property type="entry name" value="TMCO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="190" mass="22493" checksum="E81DCCFA59A98F64" modified="2022-01-19" version="1">MEILRLAQSKRNIISLNMDLERDMQRIDEANQELLLKIQERENEIQRLENEVTQTGDLAEEEEWEKDNCTTMERETALQELEEETARLERKNETLVHSITELQKKLTRKSQKITKCEQSNLDGTPEESKAKLQQLEASCADQEKELVKVMEEYAFVAQLCEDQALCIKKYQETLRKIEEELETRFLEREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYR0</accession>
    <name>A0A8C5XYR0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="12">2.1.1.386</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">HEN1 methyltransferase homolog 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HENMT1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03002887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYR0"/>
    <dbReference type="Ensembl" id="ENSMICT00000065895.1">
        <property type="protein sequence ID" value="ENSMICP00000043278.1"/>
        <property type="gene ID" value="ENSMICG00000041527.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004798"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000124">
        <property type="entry name" value="HEN methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="384" mass="43900" checksum="CDCEC2C6558CC235" modified="2022-01-19" version="1">MEEKNTQCESEVEIPSVPVIQFYPQLYKQRYRFVEDLVYRYEPKKVADLGCGDASLLRQLKKLSCIELLVGVDIKDEWQNLVTLMPDTTFGFLELTIILYQGSVVERDSRLLGFDMITCIELIEHLNPDDLAKFPEVVFGYLSPSMVVISTPNSDFNPLFEVVTVRDFDHKFEWSRKEFQSWALRVAETYSYSVEFTGVGEPPAGAESVGFCTQIGIFRKNGAKAAESCASEQREQHVYKWWTLLELANQIVVTISFPSLQQEKYFKTTVVSEVCKQVKIMRMEYLRGLKEQEEGREPSNESDPRLLAPMLWEGQLYTEAEKARIEASAKPFSVKDKFYVPLQRLPAYVRLHHLGVSEERIRSVLADSGTLSSDGSAVAIDLHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZF2</accession>
    <name>A0A8C5XZF2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
            <ecNumber evidence="7">3.5.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartylglucosaminidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosylasparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AGA</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11544"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15947"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58080"/>
            <dbReference type="EC" id="3.5.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Ntn-hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.26" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03018847">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626187.1">
        <property type="nucleotide sequence ID" value="XM_012770733.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000065536.1">
        <property type="protein sequence ID" value="ENSMICP00000043894.1"/>
        <property type="gene ID" value="ENSMICG00000009153.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874671"/>
    <dbReference type="KEGG" id="mmur:105874671"/>
    <dbReference type="CTD" id="175"/>
    <dbReference type="GeneTree" id="ENSGT00950000183045"/>
    <dbReference type="OMA" id="YKPIINI"/>
    <dbReference type="OrthoDB" id="188713at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003948">
        <property type="term" value="F:N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04513">
        <property type="entry name" value="Glycosylasparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000003">
        <property type="entry name" value="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF6">
        <property type="entry name" value="N(4)-(BETA-N-ACETYLGLUCOSAMINYL)-L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150413" description="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="234"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="257"/>
            <end position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="15">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00050421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00066729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="346" mass="37093" checksum="BBD72099E1728BC5" modified="2022-01-19" version="1">MARKSNLFVLLAPLLLGPALVRGCGPLPLVLNTWPFKNATEAAWRTLVSGGSSLDAVENGCATCEREQCDGTVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRQIKNAIGVARKVLEHTTHTLLAGESATKFAESMGFINENLSTNTSRALHSDWLARNCQPNYWRNVIPDASKYCGPYKPPSILKQDDPTYKETGADRGHDTIGMVVIHKTGRTAAGTSTNGLKFKIPGRIGDSPVPGSGAYADDAAGAAAATGDGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKYYPKFFGAVICANVTGSYGAACNKLSTFTQFSFMVYNPLKNQPTEEKVDCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y563</accession>
    <name>A0A8C5Y563_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">formyltetrahydrofolate dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-10-formyltetrahydrofolate + NADP(+) + H2O = (6S)-5,6,7,8-tetrahydrofolate + CO2 + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="1.5.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10181"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.6" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03025980">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025982">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025983">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03025984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y563"/>
    <dbReference type="Ensembl" id="ENSMICT00000058773.1">
        <property type="protein sequence ID" value="ENSMICP00000045647.1"/>
        <property type="gene ID" value="ENSMICG00000042999.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160913"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016155">
        <property type="term" value="F:formyltetrahydrofolate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009258">
        <property type="term" value="P:10-formyltetrahydrofolate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000002">
        <property type="entry name" value="10-formyltetrahydrofolate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000038">
        <property type="entry name" value="Aldehyde dehydrogenase 1 family member L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="FMT C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="109"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="297" mass="32607" checksum="1B4EADA47E3BEB7C" modified="2022-01-19" version="1">TLIHGDKKGGFTVFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGVKGMVQAVRLIAEGKAPRIPQPEEGATYEGIQKKETAMVNWDQPAEAIHNWIRGHDKVPGAWTEAGGQSAWQRILPNVLEVEDSTDFFKAGAASVDVVRLVEEVKELCEGLELENEDVYMATTFGDFVQLLVRKLRGEDEDAQPPIDYVELAVNKRCVRVPHQLFIGGAFVEAEDGKTYDTINPTDGSVICQVSLAQASDVDKAVAAAKDAFENGLWGKISARDRGRLLYRAPRSPSTMPGPTVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YB24</accession>
    <name>A0A8C5YB24_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein phosphatase 1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PPP1R12B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
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                <person name="Yoder A."/>
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    <sequence length="94" mass="10281" checksum="73EB6008EB307B39" modified="2022-01-19" version="1">ISKFGFAIGSQTTKKASAISIKLGSSKPKETVPTLAPKTLSVAAAFNEDKDSEPEEMPPEAKMRMKNIGRDTPTSKLWERNIKSHLGNVHDQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YE41</accession>
    <name>A0A8C5YE41_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leucine rich repeat transmembrane neuronal 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LRRTM2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Postsynaptic cell membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LRRTM family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022477">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604263.1">
        <property type="nucleotide sequence ID" value="XM_012748809.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YE41"/>
    <dbReference type="Ensembl" id="ENSMICT00000066677.1">
        <property type="protein sequence ID" value="ENSMICP00000049641.1"/>
        <property type="gene ID" value="ENSMICG00000047009.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105862515"/>
    <dbReference type="KEGG" id="mmur:105862515"/>
    <dbReference type="CTD" id="26045"/>
    <dbReference type="GeneTree" id="ENSGT00940000160581"/>
    <dbReference type="OrthoDB" id="2325980at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002091">
        <property type="term" value="P:negative regulation of receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000005">
        <property type="entry name" value="leucine-rich repeat transmembrane neuronal protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF22">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN COMPLEX ACID LABILE SUBUNIT ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150554" evidence="14">
        <location>
            <begin position="34"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="516" mass="59093" checksum="488C561429C7098B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEM5</accession>
    <name>A0A8C5YEM5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIPA like domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NIPAL4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIPA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027445">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139300.1">
        <property type="nucleotide sequence ID" value="XM_020283711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEM5"/>
    <dbReference type="Ensembl" id="ENSMICT00000062583.1">
        <property type="protein sequence ID" value="ENSMICP00000049869.1"/>
        <property type="gene ID" value="ENSMICG00000001010.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880479"/>
    <dbReference type="CTD" id="348938"/>
    <dbReference type="GeneTree" id="ENSGT00940000159087"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF7">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="404" mass="43775" checksum="6B788F8ADFBBC8A0" modified="2022-01-19" version="1">MELRVSNASCENGSLINLYCSSQQVLCQIVGDLVPEAPSNATSISWQERVRQSYGFYIGLGLAFLSSFLIGSSVILKKKGLQRLVATGATRAVDGGYGYLKDAMWWAGFLTMAAGEVANFGAYAFAPATVITPLGALSVLISAILSSYFLGETLNLLGKLGCVICVAGSTVMVIHAPEEERVTTVMEMASKMKDTGYIVFAVLLVVSCLILIFIVAPRYGQRNILVYIVICSVIGAFSVAAVKGLGITIKNFFQGLPVVRHPLPYILSLILALSLSTQVNFLNRALDIFNTSLVFPIYYVFFTTVVVTSSITLFKEWNSMSAVDIVGTLSGFVTIILGVFMLHAFRDLDISWASLPHTHKNPPPPPAPEPTVIRLEDKNVLVDNIELASTPSPEEKPKVFTIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFH5</accession>
    <name>A0A8C5YFH5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">V-set and transmembrane domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">VSTM5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical development in the brain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Can homooligomerize through cis interactions within the same cell membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006652">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006653">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142248.1">
        <property type="nucleotide sequence ID" value="XM_020286659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000062747.1">
        <property type="protein sequence ID" value="ENSMICP00000050026.1"/>
        <property type="gene ID" value="ENSMICG00000045625.1"/>
    </dbReference>
    <dbReference type="CTD" id="387804"/>
    <dbReference type="GeneTree" id="ENSGT01130000278319"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046847">
        <property type="term" value="P:filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904891">
        <property type="term" value="P:positive regulation of excitatory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021517">
        <property type="term" value="P:ventral spinal cord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001595">
        <property type="entry name" value="V-set and transmembrane domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015631">
        <property type="entry name" value="CD2/SLAM_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024303">
        <property type="entry name" value="NK_rcpt_2B4_Ig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080">
        <property type="entry name" value="SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12080:SF93">
        <property type="entry name" value="V-SET AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11465">
        <property type="entry name" value="Receptor_2B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150595" description="V-set and transmembrane domain-containing protein 5" evidence="16">
        <location>
            <begin position="27"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="17">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="200" mass="22521" checksum="CE71618E352C8C19" modified="2022-01-19" version="1">MRPLPSCRRKTRGISLGLFALCLAAARCLQSQGVSLYIPQPTINATVKQDILFSVEYSCHGVPTIEWTYTSNWGMQKIVEWKPGTQANISQSHQDRVCTFDNGSIQLFSVGVRDSGYYIVTVTERPGSSQFGTIVLHVSEILYEDLHLVAVFLAFLTAVAAVLISLLWVCNKCAYKFQRKRRHKLKESTTEEIELQDVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJR1</accession>
    <name>A0A8C5YJR1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DCN1-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Defective in cullin neddylation protein 1-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DCUN1D1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03000939">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592417.1">
        <property type="nucleotide sequence ID" value="XM_012736963.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YJR1"/>
    <dbReference type="SMR" id="A0A8C5YJR1"/>
    <dbReference type="Ensembl" id="ENSMICT00000072514.1">
        <property type="protein sequence ID" value="ENSMICP00000051814.1"/>
        <property type="gene ID" value="ENSMICG00000049045.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105855790"/>
    <dbReference type="CTD" id="54165"/>
    <dbReference type="GeneTree" id="ENSGT00940000154552"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000436">
        <property type="term" value="P:positive regulation of protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Cullin, PONY binding domain"/>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
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    <sequence length="259" mass="30124" checksum="F3709235E0610C54" modified="2022-01-19" version="1">MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EFH9</accession>
    <name>A0A8C6EFH9_MICMU</name>
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        <submittedName>
            <fullName evidence="10">Trinucleotide repeat containing adaptor 6A</fullName>
        </submittedName>
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        <name evidence="10" type="primary">TNRC6A</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the GW182 family.</text>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1971" mass="211786" checksum="1B78515AEAC32891" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EI82</accession>
    <name>A0A8C6EI82_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 709</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF709</name>
        <name evidence="15" type="synonym">LOC105885528</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EI82"/>
    <dbReference type="Ensembl" id="ENSMICT00000066037.1">
        <property type="protein sequence ID" value="ENSMICP00000043789.1"/>
        <property type="gene ID" value="ENSMICG00000041711.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182755"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000744">
        <property type="entry name" value="zinc finger E-box-binding homeobox 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000838">
        <property type="entry name" value="Zinc finger protein 14"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001223">
        <property type="entry name" value="Zinc finger protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000193">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002306">
        <property type="entry name" value="Zinc finger protein 433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000371">
        <property type="entry name" value="Zinc finger protein 555"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000156">
        <property type="entry name" value="Zinc finger protein 568"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001544">
        <property type="entry name" value="Zinc finger protein 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000493">
        <property type="entry name" value="Zinc finger protein 805"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="225"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="281"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="642" mass="75027" checksum="9A4E7C8C19B56C4F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJK0</accession>
    <name>A0A8C6EJK0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105864536</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142346.1">
        <property type="nucleotide sequence ID" value="XM_020286757.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJK0"/>
    <dbReference type="Ensembl" id="ENSMICT00000062595.1">
        <property type="protein sequence ID" value="ENSMICP00000047198.1"/>
        <property type="gene ID" value="ENSMICG00000046486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105864536"/>
    <dbReference type="KEGG" id="mmur:105864536"/>
    <dbReference type="GeneTree" id="ENSGT01010000222320"/>
    <dbReference type="OrthoDB" id="9603828at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000646">
        <property type="entry name" value="Olfactory receptor 887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:001035">
        <property type="entry name" value="Putative olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="130"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="34613" checksum="6CC99F29D260C2B6" modified="2022-01-19" version="1">MAAENSSSVTEFILSGLTDQPELQIPLFFLFLGFYVVTVVGNLGLITLIGLNSHLHIPMYFFLFNLSFIDFSYSTTLTPKMLMSFVLKKNIISYAGCMTQFFFFCFFVFSESYILSAMAYDRYVAICKPLLYTVTMSPQVCLLLLSGVYGMGVFGAVAHMGNLMFMTFCADNLVNHYMCDIIPLLELSCNSTYVNLLVVFIVVTIGIGVPIVTIFISYGFILSSILHISSMEGRSKAFSTCSSHIIVVSLFFGSGAFMYLKPPSILPLDQGKVSSVFYTAVVPMFNPLIYSLRNKDVKIALKKTLSRKILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EEV0</accession>
    <name>A0A8B7EEV0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Signal recognition particle 54 kDa protein</fullName>
            <ecNumber evidence="15">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SRP54</name>
        <name evidence="17" type="synonym">FAM177A1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 15">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="13 15">Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. Interacts with RNPS1. Interacts with the SRP receptor subunit SRPRA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03004153">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591952.1">
        <property type="nucleotide sequence ID" value="XM_012736498.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591953.1">
        <property type="nucleotide sequence ID" value="XM_012736499.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591954.1">
        <property type="nucleotide sequence ID" value="XM_012736500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EEV0"/>
    <dbReference type="SMR" id="A0A8B7EEV0"/>
    <dbReference type="Ensembl" id="ENSMICT00000051778.2">
        <property type="protein sequence ID" value="ENSMICP00000027040.1"/>
        <property type="gene ID" value="ENSMICG00000010270.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855489"/>
    <dbReference type="KEGG" id="mmur:105855489"/>
    <dbReference type="GeneTree" id="ENSGT00550000074824"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000002">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="16">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="504" mass="55705" checksum="7D7630A43BC5EC2C" modified="2022-01-19" version="1">MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVANAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EI74</accession>
    <name>A0A8B7EI74_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ADAM metallopeptidase domain 23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ADAM23</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594331.1">
        <property type="nucleotide sequence ID" value="XM_012738877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EI74"/>
    <dbReference type="Ensembl" id="ENSMICT00000066910.1">
        <property type="protein sequence ID" value="ENSMICP00000045484.1"/>
        <property type="gene ID" value="ENSMICG00000009477.3"/>
    </dbReference>
    <dbReference type="CTD" id="8745"/>
    <dbReference type="GeneTree" id="ENSGT00940000158781"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000147">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000014">
        <property type="entry name" value="disintegrin and metalloproteinase domain-containing protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000001">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013111">
        <property type="entry name" value="EGF_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002870">
        <property type="entry name" value="Peptidase_M12B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF13">
        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08516">
        <property type="entry name" value="ADAM_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07974">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01562">
        <property type="entry name" value="Pep_M12B_propep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="9 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="17">
        <location>
            <begin position="295"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="16">
        <location>
            <begin position="498"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="15">
        <location>
            <begin position="728"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="828" mass="91676" checksum="CC47F9956D4535FD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EK99</accession>
    <name>A0A8B7EK99_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras association domain family member 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RASSF8</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03009969">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594994.2">
        <property type="nucleotide sequence ID" value="XM_012739540.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594995.2">
        <property type="nucleotide sequence ID" value="XM_012739541.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EK99"/>
    <dbReference type="Ensembl" id="ENSMICT00000034384.2">
        <property type="protein sequence ID" value="ENSMICP00000036423.2"/>
        <property type="gene ID" value="ENSMICG00000006156.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000063112.1">
        <property type="protein sequence ID" value="ENSMICP00000044546.1"/>
        <property type="gene ID" value="ENSMICG00000006156.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105857282"/>
    <dbReference type="CTD" id="11228"/>
    <dbReference type="GeneTree" id="ENSGT00950000182839"/>
    <dbReference type="OrthoDB" id="10051571at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16134">
        <property type="entry name" value="RA_RASSF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033593">
        <property type="entry name" value="N-RASSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
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    <dbReference type="InterPro" id="IPR048945">
        <property type="entry name" value="RASSF8/10_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048944">
        <property type="entry name" value="RASSF8_RA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286:SF9">
        <property type="entry name" value="RAS ASSOCIATION DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15286">
        <property type="entry name" value="RAS-ASSOCIATING DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21712">
        <property type="entry name" value="RASSF8-10_RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036423.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="419" mass="48224" checksum="A333862EFDE12009" modified="2022-01-19" version="1">MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPIISLNKWGQYASDVQLILRRTGPSLGERPTSDSVARIPERTLYRQSLPPLAKLRPQIDKSIKRREPKRKSLTFTGGAKGLMDIFGKGKETEFKQKVLNNCRTTADELKKLVHLQTEKLQSIEKQLESNEIEIRFWEQKYNSNLEEEIVRLEQKIKKNDVEIEEEEFWENELQIEQENEKQLKDQLQEIRQKITECESKLKDYLAQIQTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLRLENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPTEIEASHADIQREVPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EU34</accession>
    <name>A0A8B7EU34_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beclin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">BECN1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasmic vesicle</location>
            <location evidence="4">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endosome membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the beclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020172">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598711.1">
        <property type="nucleotide sequence ID" value="XM_012743257.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598712.1">
        <property type="nucleotide sequence ID" value="XM_012743258.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598713.1">
        <property type="nucleotide sequence ID" value="XM_012743259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EU34"/>
    <dbReference type="Ensembl" id="ENSMICT00000058732.1">
        <property type="protein sequence ID" value="ENSMICP00000048842.1"/>
        <property type="gene ID" value="ENSMICG00000010391.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859442"/>
    <dbReference type="KEGG" id="mmur:105859442"/>
    <dbReference type="CTD" id="8678"/>
    <dbReference type="GeneTree" id="ENSGT00390000008164"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032473">
        <property type="term" value="C:cytoplasmic side of mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050435">
        <property type="term" value="P:amyloid-beta metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Atg6/Beclin"/>
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        <property type="entry name" value="BH3_dom"/>
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        <property type="entry name" value="BH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="14 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beclin-1 BH3" evidence="22">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="23">
        <location>
            <begin position="133"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="21">
        <location>
            <begin position="262"/>
            <end position="443"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="47"/>
            <end position="66"/>
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    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="143"/>
            <end position="265"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004150"/>
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    <sequence length="448" mass="51662" checksum="B22B8D9D9D2C06A7" modified="2022-01-19" version="1">MEGSKSSNSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELTELALEEERLIQELEDVEKNRKMVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQMQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EUA1</accession>
    <name>A0A8B7EUA1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="4 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NTAQ1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="4 8"/>
    <dbReference type="EMBL" id="ABDC03013406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598792.1">
        <property type="nucleotide sequence ID" value="XM_012743338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EUA1"/>
    <dbReference type="Ensembl" id="ENSMICT00000063574.1">
        <property type="protein sequence ID" value="ENSMICP00000044707.1"/>
        <property type="gene ID" value="ENSMICG00000036520.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105859515"/>
    <dbReference type="CTD" id="55093"/>
    <dbReference type="GeneTree" id="ENSGT00390000014398"/>
    <dbReference type="OrthoDB" id="191192at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.10:FF:000001">
        <property type="entry name" value="Blast:Protein N-terminal glutamine amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="9">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="208" mass="23885" checksum="09FCF540CE926355" modified="2022-01-19" version="1">MDGDATAAATAACYQPASPPRDACVYSSCYCEENIWKLCEYIKNHNQYPLEECYAVFISNERKMVPIWKQQTRPGSGPVIWDYHVVLLHVSSGGQSFIYDLDTVLPFPCLFDTYVEDAFKSDDDIHPQFRRKFRVIRADSYLKNFASDRSHMKDSSGNWREPPPPYPCIETGDSKMNLNDFISMDPEVGWGAVYTLSEFVHRFGSKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2N8</accession>
    <name>A0A8B7F2N8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cold-inducible RNA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycine-rich RNA-binding protein CIRP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CIRBP</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with EIF4G1. Associates with ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601227.1">
        <property type="nucleotide sequence ID" value="XM_012745773.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F2N8"/>
    <dbReference type="Ensembl" id="ENSMICT00000070474.1">
        <property type="protein sequence ID" value="ENSMICP00000041886.1"/>
        <property type="gene ID" value="ENSMICG00000038000.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860780"/>
    <dbReference type="CTD" id="1153"/>
    <dbReference type="GeneTree" id="ENSGT00940000153524"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12449">
        <property type="entry name" value="RRM_CIRBP_RBM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000174">
        <property type="entry name" value="cold-inducible RNA-binding protein isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034278">
        <property type="entry name" value="RBM3/CIRBP_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="172" mass="18545" checksum="E43B0E1A4E781411" modified="2022-01-19" version="1">MASDEGKLFVGGLSFDTNEQSLEQVFSKYGQIAEVVVVKDRETQRSRGFGFVTFENIDDAKDAMMAMNGKSVDGRQIRVDQAGKSSDNRSRGYRGGSAGGRGFFRGGRGRGRGFSRGGGDRGYGGGRFESRSGGYGGSRDYYSSRSQGSGYGDRSSGGSYRDSYDSYATHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F396</accession>
    <name>A0A8B7F396_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BCL2 interacting protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BNIP5</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03007452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F396"/>
    <dbReference type="Ensembl" id="ENSMICT00000011172.3">
        <property type="protein sequence ID" value="ENSMICP00000010174.2"/>
        <property type="gene ID" value="ENSMICG00000011173.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105861449"/>
    <dbReference type="CTD" id="389384"/>
    <dbReference type="GeneTree" id="ENSGT00390000001176"/>
    <dbReference type="OrthoDB" id="9836802at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031362">
        <property type="entry name" value="BNIP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22435">
        <property type="entry name" value="CHROMOSOME 6 OPEN READING FRAME 222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22435:SF0">
        <property type="entry name" value="PROTEIN BNIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15661">
        <property type="entry name" value="CF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010174.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="643" mass="69609" checksum="50726DAEC8D86E29" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F3S8</accession>
    <name>A0A8B7F3S8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAD50-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RAD50 interactor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RINT1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RINT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602100.1">
        <property type="nucleotide sequence ID" value="XM_012746646.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F3S8"/>
    <dbReference type="Ensembl" id="ENSMICT00000010949.3">
        <property type="protein sequence ID" value="ENSMICP00000009971.2"/>
        <property type="gene ID" value="ENSMICG00000010945.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861251"/>
    <dbReference type="KEGG" id="mmur:105861251"/>
    <dbReference type="CTD" id="60561"/>
    <dbReference type="GeneTree" id="ENSGT00390000017006"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000003">
        <property type="entry name" value="RAD50-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00073943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00079551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009971.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="792" mass="90799" checksum="A7C616F2A01A6D25" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F623</accession>
    <name>A0A8B7F623_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Adenosine deaminase 2</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cat eye syndrome critical region protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ADA2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adenosine deaminase that may contribute to the degradation of extracellular adenosine, a signaling molecule that controls a variety of cellular responses. Requires elevated adenosine levels for optimal enzyme activity. Binds to cell surfaces via proteoglycans and may play a role in the regulation of cell proliferation and differentiation, independently of its enzyme activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Interacts with adenosine receptors. Binds heparin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03009489">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009490">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603212.1">
        <property type="nucleotide sequence ID" value="XM_012747758.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603213.1">
        <property type="nucleotide sequence ID" value="XM_012747759.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F623"/>
    <dbReference type="Ensembl" id="ENSMICT00000050246.2">
        <property type="protein sequence ID" value="ENSMICP00000035080.1"/>
        <property type="gene ID" value="ENSMICG00000028193.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105861873"/>
    <dbReference type="KEGG" id="mmur:105861873"/>
    <dbReference type="CTD" id="51816"/>
    <dbReference type="GeneTree" id="ENSGT00950000183113"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031685">
        <property type="term" value="F:adenosine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043394">
        <property type="term" value="F:proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01321">
        <property type="entry name" value="ADGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013659">
        <property type="entry name" value="A_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006331">
        <property type="entry name" value="ADGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01431">
        <property type="entry name" value="adm_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08451">
        <property type="entry name" value="A_deaminase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133515" description="Adenosine deaminase 2" evidence="14">
        <location>
            <begin position="30"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine/AMP deaminase N-terminal" evidence="16">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="15">
        <location>
            <begin position="194"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="513" mass="58637" checksum="F45BFA4DB4E0282E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F7R5</accession>
    <name>A0A8B7F7R5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphopantothenate--cysteine ligase</fullName>
            <ecNumber evidence="5">6.3.2.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphopantothenoylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PPCS</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-4'-phosphopantothenate + L-cysteine + ATP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25156"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.51"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:25157"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:19398"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.51" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03001576">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603933.1">
        <property type="nucleotide sequence ID" value="XM_012748479.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F7R5"/>
    <dbReference type="Ensembl" id="ENSMICT00000014926.3">
        <property type="protein sequence ID" value="ENSMICP00000013609.3"/>
        <property type="gene ID" value="ENSMICG00000014936.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862279"/>
    <dbReference type="KEGG" id="mmur:105862279"/>
    <dbReference type="CTD" id="79717"/>
    <dbReference type="GeneTree" id="ENSGT00950000182834"/>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="OrthoDB" id="3174329at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003015">
        <property type="term" value="P:heart process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10300:FF:000002">
        <property type="entry name" value="Phosphopantothenate--cysteine ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="8">
        <location>
            <begin position="166"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00051127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00052332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00068949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013609.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="33955" checksum="290A74FF1DE1C4F8" modified="2022-01-19" version="1">MAEMDLVAEFPRPAGAARWAEVMARFAARLGAQGRRVVLVTSGGTKVPLEARPVRFLDNFSSGRRGATSAEAFLAAGYGVLFLYRARSAFPFAHRFPPQTWLSALRPSGPAHSGLLSLEAEENALPGFAAALRSYQEAVAAGTFMAVEFTTLADYLHLLQAAAQALNPLGSTAMFYLAAAVSDFYVPVSEMPEHKIQSSGGLLQITMKMVPKMLSPLVKDWAPKAFIISFKLETDPSIVINRARNALEIYQHQVVVANILESRQSCVVIVTKDSETKLLLSEEEVGKGIEIEEKIVDNLRSRHTAFICEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FBW6</accession>
    <name>A0A8B7FBW6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Empty spiracles homeobox 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EMX1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMX homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605661.1">
        <property type="nucleotide sequence ID" value="XM_012750207.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7FBW6"/>
    <dbReference type="Ensembl" id="ENSMICT00000030539.2">
        <property type="protein sequence ID" value="ENSMICP00000026768.1"/>
        <property type="gene ID" value="ENSMICG00000032816.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863280"/>
    <dbReference type="KEGG" id="mmur:105863280"/>
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    <dbReference type="GeneTree" id="ENSGT00940000161476"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleolus"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:brain morphogenesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0021895">
        <property type="term" value="P:cerebral cortex neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0021796">
        <property type="term" value="P:cerebral cortex regionalization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048872">
        <property type="term" value="P:homeostasis of number of cells"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060563">
        <property type="term" value="P:neuroepithelial cell differentiation"/>
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        <property type="term" value="P:neuron projection extension"/>
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        <property type="term" value="P:post-embryonic development"/>
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        <property type="term" value="P:radial glial cell differentiation"/>
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    <dbReference type="GO" id="GO:0070445">
        <property type="term" value="P:regulation of oligodendrocyte progenitor proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000299">
        <property type="entry name" value="Empty spiracles homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050877">
        <property type="entry name" value="EMX-VAX-Noto_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339:SF28">
        <property type="entry name" value="E5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24339">
        <property type="entry name" value="HOMEOBOX PROTEIN EMX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="190"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="192"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="249"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007397"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026768.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="290" mass="31256" checksum="1E48D8B6B09ED934" modified="2022-01-19" version="1">MCLAGCTPRTAAAPGRGALPRARLPQTAPAAATMFQPAAKRGFTIESLVAKDGGTGGGTGGGGAGSHPLAAAASEEPLRPTALNYPHPSAAEAAFVSGFPAAAAAGAGRSLYGGPELVFPEAMNHPALTMHPAHQLGASPLQPPHSFFGAQHRDPLHFYPWVLRNRFFGHRFQASDVPQDGLLLHGPFARKPKRIRTAFSPSQLLRLERAFEKNHYVVGAERKQLAGSLSLSETQVKVWFQNRRTKYKRQKLEEEGPESEQKKKGSHHINRWRIATKQANGEDIDVTSND</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FSY3</accession>
    <name>A0A8B7FSY3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox protein DBX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Developing brain homeobox protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DBX1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the H2.0 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006321">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612177.1">
        <property type="nucleotide sequence ID" value="XM_012756723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FSY3"/>
    <dbReference type="Ensembl" id="ENSMICT00000017107.3">
        <property type="protein sequence ID" value="ENSMICP00000015587.2"/>
        <property type="gene ID" value="ENSMICG00000017111.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867003"/>
    <dbReference type="KEGG" id="mmur:105867003"/>
    <dbReference type="CTD" id="120237"/>
    <dbReference type="GeneTree" id="ENSGT00950000183093"/>
    <dbReference type="OrthoDB" id="10048112at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021521">
        <property type="term" value="P:ventral spinal cord interneuron specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000177">
        <property type="entry name" value="Homeobox protein DBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051662">
        <property type="entry name" value="H2.0_Homeobox_NeuralPatt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331">
        <property type="entry name" value="DBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24331:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN DBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="2 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="179"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="181"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="315"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015587.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="344" mass="37404" checksum="3CB2B93FC86150B7" modified="2022-01-19" version="1">MMFPGLLAPPAGYPSLLRPTPTLTLPQSLQSAFSGHSSFLVEDLIRISRPPAYLPRSVPTASMSPPRQGAPGALADSGSSDLGSPGSGNRRGGSPPTAVSPASEPTFLKFGVNAILASGPRTETSPALLQSVPPKTFAFPYFEGSFQPFIRSSYFPASSSVVPIPGTFSWPLAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNRRMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGDDEEEDEVPGSPRHRLAYRASPEPPHLRDPRLEGPLPPSPAHSSSPGKPSDFSDSEEDEEGEEEEEITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FVN2</accession>
    <name>A0A8B7FVN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carnosine synthase 1</fullName>
            <ecNumber evidence="11">6.3.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP-grasp domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CARNS1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-aminobutanoate + L-histidine + ATP = L-homocarnosine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:59568"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="ChEBI" id="CHEBI:143075"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:59569"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19297"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57485"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.11"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19298"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.11" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03006022">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612994.1">
        <property type="nucleotide sequence ID" value="XM_012757540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FVN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000049064.2">
        <property type="protein sequence ID" value="ENSMICP00000032227.1"/>
        <property type="gene ID" value="ENSMICG00000004109.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867471"/>
    <dbReference type="KEGG" id="mmur:105867471"/>
    <dbReference type="CTD" id="57571"/>
    <dbReference type="GeneTree" id="ENSGT00390000018717"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047730">
        <property type="term" value="F:carnosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102102">
        <property type="term" value="F:homocarnosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035499">
        <property type="term" value="P:carnosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000040">
        <property type="entry name" value="Carnosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000018">
        <property type="entry name" value="Carnosine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031046">
        <property type="entry name" value="CARNS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48066">
        <property type="entry name" value="CARNOSINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48066:SF1">
        <property type="entry name" value="CARNOSINE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15632">
        <property type="entry name" value="ATPgrasp_Ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="638"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="949" mass="101030" checksum="7A3E4C268124D1D4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FZI6</accession>
    <name>A0A8B7FZI6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribosome-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ribosome receptor protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RRBP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614983.1">
        <property type="nucleotide sequence ID" value="XM_012759529.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000013708.3">
        <property type="protein sequence ID" value="ENSMICP00000012505.3"/>
        <property type="gene ID" value="ENSMICG00000013693.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868536"/>
    <dbReference type="CTD" id="6238"/>
    <dbReference type="GeneTree" id="ENSGT00940000158015"/>
    <dbReference type="OrthoDB" id="6410656at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000010">
        <property type="entry name" value="Ribosome binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007794">
        <property type="entry name" value="Rib_rcpt_KP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040248">
        <property type="entry name" value="RRBP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18939">
        <property type="entry name" value="RIBOSOME BINDING PROTEIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="9"/>
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            <begin position="33"/>
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            <dbReference type="ARBA" id="ARBA00004643"/>
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        <source>
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    <sequence length="1569" mass="169119" checksum="5F54CC28A00660C5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G1C1</accession>
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        <name type="scientific">Microcebus murinus</name>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8N6</accession>
    <name>A0A8B7G8N6_MICMU</name>
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        <submittedName>
            <fullName evidence="11">DnaJ heat shock protein family (Hsp40) member C16</fullName>
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        <name evidence="11" type="primary">DNAJC16</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Primates</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03002327">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002328">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618495.1">
        <property type="nucleotide sequence ID" value="XM_012763041.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618496.1">
        <property type="nucleotide sequence ID" value="XM_012763042.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8N6"/>
    <dbReference type="Ensembl" id="ENSMICT00000060361.1">
        <property type="protein sequence ID" value="ENSMICP00000048383.1"/>
        <property type="gene ID" value="ENSMICG00000003462.3"/>
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    <dbReference type="GeneID" id="105870441"/>
    <dbReference type="KEGG" id="mmur:105870441"/>
    <dbReference type="CTD" id="23341"/>
    <dbReference type="GeneTree" id="ENSGT00940000155851"/>
    <dbReference type="OrthoDB" id="10065037at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0016243">
        <property type="term" value="P:regulation of autophagosome size"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd02963">
        <property type="entry name" value="TRX_DnaJ"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
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        <property type="entry name" value="DnaJ_domain"/>
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        <property type="entry name" value="DNAJC16_TRX"/>
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        <property type="entry name" value="J_dom_sf"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
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    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="THIOREDOXIN_2"/>
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        <location>
            <begin position="1"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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            <dbReference type="PROSITE" id="PS51352"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
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    <sequence length="779" mass="89827" checksum="38E75C108AF29F24" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="12">E74 like ETS transcription factor 1</fullName>
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        <name evidence="12" type="primary">ELF1</name>
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    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ETS family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012620432.1">
        <property type="nucleotide sequence ID" value="XM_012764978.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157039"/>
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    <dbReference type="Proteomes" id="UP000694394">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050860">
        <property type="term" value="P:negative regulation of T cell receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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    <dbReference type="Gene3D" id="1.10.10.10">
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    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022084">
        <property type="entry name" value="TF_Elf_N"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF156">
        <property type="entry name" value="ETS-RELATED TRANSCRIPTION FACTOR ELF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12310">
        <property type="entry name" value="Elf-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="156"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="298"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="617" mass="67181" checksum="7CA80C7C58D89BED" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GG91</accession>
    <name>A0A8B7GG91_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum membrane sensor NFE2L1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Nuclear factor erythroid 2-related factor 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Nuclear factor, erythroid derived 2, like 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">NFE2L1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the bZIP family. CNC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020112">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020113">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621469.1">
        <property type="nucleotide sequence ID" value="XM_012766015.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GG91"/>
    <dbReference type="Ensembl" id="ENSMICT00000033620.2">
        <property type="protein sequence ID" value="ENSMICP00000026582.1"/>
        <property type="gene ID" value="ENSMICG00000014716.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872165"/>
    <dbReference type="CTD" id="4779"/>
    <dbReference type="GeneTree" id="ENSGT00950000182892"/>
    <dbReference type="OrthoDB" id="7458135at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14720">
        <property type="entry name" value="bZIP_NFE2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.880.10:FF:000001">
        <property type="entry name" value="Nuclear factor erythroid 2-related factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.880.10">
        <property type="entry name" value="Transcription factor, Skn-1-like, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004826">
        <property type="entry name" value="bZIP_Maf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047167">
        <property type="entry name" value="NFE2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008917">
        <property type="entry name" value="TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411:SF31">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MEMBRANE SENSOR NFE2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24411">
        <property type="entry name" value="NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03131">
        <property type="entry name" value="bZIP_Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47454">
        <property type="entry name" value="A DNA-binding domain in eukaryotic transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="21" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="18" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BZIP" evidence="27">
        <location>
            <begin position="624"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="108"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="440"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="446"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00030985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00031659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="742" mass="81572" checksum="8B876B920207E87C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GQ59</accession>
    <name>A0A8B7GQ59_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DAPK3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03028031">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624752.1">
        <property type="nucleotide sequence ID" value="XM_012769298.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GQ59"/>
    <dbReference type="Ensembl" id="ENSMICT00000061248.1">
        <property type="protein sequence ID" value="ENSMICP00000049405.1"/>
        <property type="gene ID" value="ENSMICG00000046071.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873943"/>
    <dbReference type="KEGG" id="mmur:105873943"/>
    <dbReference type="CTD" id="1613"/>
    <dbReference type="GeneTree" id="ENSGT00940000161753"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043522">
        <property type="term" value="F:leucine zipper domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071346">
        <property type="term" value="P:cellular response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043519">
        <property type="term" value="P:regulation of myosin II filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14105">
        <property type="entry name" value="STKc_DAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000110">
        <property type="entry name" value="Death-associated kinase 3, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000250">
        <property type="entry name" value="Death-associated protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042870">
        <property type="entry name" value="DAPK3_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF18">
        <property type="entry name" value="DEATH-ASSOCIATED PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="13"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="371"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="454" mass="52708" checksum="375153FD47F220F5" modified="2022-01-19" version="1">MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKDVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRNEDSGQKPERRRLKTTRLKEYTIKSHSSMPPNNTYVNFERFSKVLEEVAAAEEGLRELERSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELHKTEALKRQAQEEARGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGTECGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GSS4</accession>
    <name>A0A8B7GSS4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TCF3 fusion partner</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TFPT</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626289.1">
        <property type="nucleotide sequence ID" value="XM_012770835.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GSS4"/>
    <dbReference type="Ensembl" id="ENSMICT00000041943.2">
        <property type="protein sequence ID" value="ENSMICP00000019818.1"/>
        <property type="gene ID" value="ENSMICG00000036691.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874713"/>
    <dbReference type="KEGG" id="mmur:105874713"/>
    <dbReference type="CTD" id="29844"/>
    <dbReference type="GeneTree" id="ENSGT00390000016605"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904507">
        <property type="term" value="P:positive regulation of telomere maintenance in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060382">
        <property type="term" value="P:regulation of DNA strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033555">
        <property type="entry name" value="TFPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35084:SF1">
        <property type="entry name" value="TCF3 FUSION PARTNER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="253" mass="28337" checksum="8C5B01F2CC8D7293" modified="2022-01-19" version="1">MELEQREGTMAAVGFDEFSAPPGSELALPPLFGGHILESELETEVEFVSGGLGSSGLRERDEEEEAARGRRRRQRELNRRKYQALGRRCREIEQVNERVLNRLHQVQRITRRLQQERRFLMRVLDSYGDDYRASQFTIVLEDEGSQGTDAPTPGNAENEPPEKEGLSPPRRTPIPPEPSSPAPGEGPSGRKRRRAPRDGRRAGAALTPELAPVQIKVEEDFGFEADEALDSSWVSRGPDKLLPYPTLASPPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GUA5</accession>
    <name>A0A8B7GUA5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Poly [ADP-ribose] polymerase</fullName>
            <shortName evidence="17">PARP</shortName>
            <ecNumber evidence="17">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PARP3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="16">Interacts with PARP1; leading to activate PARP1 in absence of DNA. Interacts with PRKDC. Interacts with XRCC5/Ku80; the interaction is dependent on nucleic acids. Interacts with XRCC6/Ku70; the interaction is dependent on nucleic acids. Interacts with EZH2, HDAC1, HDAC2, SUZ12, YY1, LRIG3 and LIG4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the ARTD/PARP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03018255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626921.1">
        <property type="nucleotide sequence ID" value="XM_012771467.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626923.1">
        <property type="nucleotide sequence ID" value="XM_012771469.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626924.1">
        <property type="nucleotide sequence ID" value="XM_012771470.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626925.1">
        <property type="nucleotide sequence ID" value="XM_012771471.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626926.1">
        <property type="nucleotide sequence ID" value="XM_012771472.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626927.1">
        <property type="nucleotide sequence ID" value="XM_012771473.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135948.1">
        <property type="nucleotide sequence ID" value="XM_020280359.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135949.1">
        <property type="nucleotide sequence ID" value="XM_020280360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GUA5"/>
    <dbReference type="Ensembl" id="ENSMICT00000017295.3">
        <property type="protein sequence ID" value="ENSMICP00000015754.2"/>
        <property type="gene ID" value="ENSMICG00000017294.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000060017.1">
        <property type="protein sequence ID" value="ENSMICP00000046982.1"/>
        <property type="gene ID" value="ENSMICG00000017294.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875029"/>
    <dbReference type="KEGG" id="mmur:105875029"/>
    <dbReference type="CTD" id="10039"/>
    <dbReference type="GeneTree" id="ENSGT00940000158855"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140294">
        <property type="term" value="F:NAD DNA ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003950">
        <property type="term" value="F:NAD+ poly-ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140806">
        <property type="term" value="F:NAD+-protein-aspartate ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140807">
        <property type="term" value="F:NAD+-protein-glutamate ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140804">
        <property type="term" value="F:NAD+-protein-lysine ADP-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030592">
        <property type="term" value="P:DNA ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045829">
        <property type="term" value="P:negative regulation of isotype switching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001034">
        <property type="term" value="P:positive regulation of double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070213">
        <property type="term" value="P:protein auto-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990166">
        <property type="term" value="P:protein localization to site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070212">
        <property type="term" value="P:protein poly-ADP-ribosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01437">
        <property type="entry name" value="parp_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08002">
        <property type="entry name" value="WGR_PARP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.142.10:FF:000006">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.140.10:FF:000001">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.10:FF:000009">
        <property type="entry name" value="Poly [ADP-ribose] polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.142.10">
        <property type="entry name" value="Poly(ADP-ribose) polymerase, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.140.10">
        <property type="entry name" value="WGR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050800">
        <property type="entry name" value="ARTD/PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012317">
        <property type="entry name" value="Poly(ADP-ribose)pol_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004102">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036616">
        <property type="entry name" value="Poly(ADP-ribose)pol_reg_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036930">
        <property type="entry name" value="WGR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008893">
        <property type="entry name" value="WGR_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459">
        <property type="entry name" value="DNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10459:SF66">
        <property type="entry name" value="PROTEIN MONO-ADP-RIBOSYLTRANSFERASE PARP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00644">
        <property type="entry name" value="PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02877">
        <property type="entry name" value="PARP_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05406">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00773">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47587">
        <property type="entry name" value="Domain of poly(ADP-ribose) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142921">
        <property type="entry name" value="WGR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51060">
        <property type="entry name" value="PARP_ALPHA_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51059">
        <property type="entry name" value="PARP_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51977">
        <property type="entry name" value="WGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 17" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WGR" evidence="21">
        <location>
            <begin position="58"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PARP alpha-helical" evidence="20">
        <location>
            <begin position="180"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="PARP catalytic" evidence="19">
        <location>
            <begin position="311"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015754.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="531" mass="59741" checksum="6A1FE9B91E47A5D4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GZ31</accession>
    <name>A0A8B7GZ31_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">GRIK4</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15 20">Postsynaptic cell membrane</location>
            <topology evidence="15 20">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Presynaptic cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007058">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628953.1">
        <property type="nucleotide sequence ID" value="XM_012773499.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628954.1">
        <property type="nucleotide sequence ID" value="XM_012773500.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GZ31"/>
    <dbReference type="Ensembl" id="ENSMICT00000011200.3">
        <property type="protein sequence ID" value="ENSMICP00000010200.2"/>
        <property type="gene ID" value="ENSMICG00000011188.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875994"/>
    <dbReference type="KEGG" id="mmur:105875994"/>
    <dbReference type="CTD" id="2900"/>
    <dbReference type="GeneTree" id="ENSGT00940000159111"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032983">
        <property type="term" value="C:kainate selective glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042734">
        <property type="term" value="C:presynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099507">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13724">
        <property type="entry name" value="PBP2_iGluR_kainate_KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000060">
        <property type="entry name" value="Glutamate receptor ionotropic, kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000072">
        <property type="entry name" value="glutamate receptor ionotropic, kainate 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000059">
        <property type="entry name" value="Glutamate receptor, ionotropic, kainate 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000010">
        <property type="entry name" value="Putative glutamate receptor ionotropic kainate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 20" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="9 20" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 20" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044038164" description="Glutamate receptor" evidence="20">
        <location>
            <begin position="21"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="805"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="22">
        <location>
            <begin position="417"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="23">
        <location>
            <begin position="427"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="860"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="932"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="939"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="502"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="723"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="18">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="735"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010200.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="956" mass="107221" checksum="1A87C029849046CE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H6M0</accession>
    <name>A0A8B7H6M0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GDP-fucose protein O-fucosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FUT10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo. May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63644"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:17914"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189632"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:63645"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + GDP-beta-L-fucose = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70491"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:17915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:189631"/>
            <dbReference type="EC" id="2.4.1.221"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70492"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 15">Belongs to the glycosyltransferase 10 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03023859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023860">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631196.1">
        <property type="nucleotide sequence ID" value="XM_012775742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H6M0"/>
    <dbReference type="Ensembl" id="ENSMICT00000013096.3">
        <property type="protein sequence ID" value="ENSMICP00000011938.2"/>
        <property type="gene ID" value="ENSMICG00000013099.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877333"/>
    <dbReference type="KEGG" id="mmur:105877333"/>
    <dbReference type="CTD" id="84750"/>
    <dbReference type="GeneTree" id="ENSGT00940000160287"/>
    <dbReference type="OrthoDB" id="9993460at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046920">
        <property type="term" value="F:alpha-(1-&gt;3)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021799">
        <property type="term" value="P:cerebral cortex radially oriented cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097402">
        <property type="term" value="P:neuroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036445">
        <property type="term" value="P:neuronal stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050714">
        <property type="term" value="P:positive regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11660:FF:000002">
        <property type="entry name" value="Alpha-(1,3)-fucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11660">
        <property type="entry name" value="Glycosyl transferase family 10, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017176">
        <property type="entry name" value="Alpha-1_3-FUT_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055270">
        <property type="entry name" value="Glyco_tran_10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031481">
        <property type="entry name" value="Glyco_tran_10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001503">
        <property type="entry name" value="Glyco_trans_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038577">
        <property type="entry name" value="GT10-like_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929">
        <property type="entry name" value="ALPHA- 1,3 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11929:SF194">
        <property type="entry name" value="ALPHA-(1,3)-FUCOSYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17039">
        <property type="entry name" value="Glyco_tran_10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00852">
        <property type="entry name" value="Glyco_transf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037332">
        <property type="entry name" value="Alpha1_3FUT_met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 14 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fucosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="83"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fucosyltransferase C-terminal" evidence="16">
        <location>
            <begin position="213"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF17039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011938.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="479" mass="55602" checksum="3E116AE816557F8C" modified="2022-01-19" version="1">MVRIQRRKFLASCLCITATVFLLVTLQVVVELGKFERTKFGNSNLQDGHAKMEEGPGHLNPFLKKEAPALHRKKTSGSDSYPVMLWWSPLTGETGRLGQCGADACFFTINRTYLHHPMTKAFLFYGTDFNIDSLPLPRKAHHDWALFHEESPKNNYKLFHKPVVTLFNYTATFSRHSHLPLTTQYLEGVEALKSLRYLVPLPSKNELRKRLAPLVYVQSDCDPPSDRDSYVRELMTYIEVDSYGECLRNRDLPGQLNSPVSMDADGFYRILAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPSIKDWLPSNKSAILVSEFPHPRELAGHIRRLDHDDRSYEGYVEWKLKGQISNQRLLTALRERSWGVQDISQDNYIDAFECMVCTKVWDNIRLQEKGLPPKRWKAEDTHLSCPEPTMFAFSPPRAPRWGSSREMWVRSFEQSKKEARALRWLVDRNQNFSAQEFWALVFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H7F3</accession>
    <name>A0A8B7H7F3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Raftlin family member 2</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="11">Raftlin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">RFTN2</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the raftlin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010945">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632459.1">
        <property type="nucleotide sequence ID" value="XM_012777005.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632460.1">
        <property type="nucleotide sequence ID" value="XM_012777006.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632461.1">
        <property type="nucleotide sequence ID" value="XM_012777007.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632462.1">
        <property type="nucleotide sequence ID" value="XM_012777008.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H7F3"/>
    <dbReference type="Ensembl" id="ENSMICT00000009021.3">
        <property type="protein sequence ID" value="ENSMICP00000008218.2"/>
        <property type="gene ID" value="ENSMICG00000028117.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105877940"/>
    <dbReference type="KEGG" id="mmur:105877940"/>
    <dbReference type="CTD" id="130132"/>
    <dbReference type="GeneTree" id="ENSGT00530000063609"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033227">
        <property type="term" value="P:dsRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043330">
        <property type="term" value="P:response to exogenous dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028169">
        <property type="entry name" value="Raftlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17601:SF1">
        <property type="entry name" value="RAFTLIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17601">
        <property type="entry name" value="RAFTLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15250">
        <property type="entry name" value="Raftlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008218.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012632462.1"/>
        </source>
    </evidence>
    <sequence length="499" mass="55975" checksum="D0D1AED90E35F36F" modified="2022-01-19" version="1">MGCGLRKLEDPDDSSPGKIFSTLKRPQVETKTEFAYEYVLLDFTLQASSNPEVIKINSILDIVTKVEDYYLKGYIVGAIHPVIQPVVQRKHLPASYLYRVVLSRVKLSPKHSAVPSGQRRPRLLIEECPLIYETQTNDIAKELIEKINVAAKRGMKFVGFISQHYSPSKFCNGTNHDGDIESMLHMRHSSDENCKSWNEGTLSGQSSESGIEEELHHESGQYQMEQNGSPSSPKSRKGEDNKLYIVFNAFDDDSTCWTYQEGILSMKVTRKGSIISTLDADWLELTTFYYKQGLSLIDSFVCWETSKGDHLPKSLEGFFIYEEEGSGVPGSSRKGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPILRHDSEGNLATKQVVFLQRPVMWNSAAQTPDRKASQHVKGEDRNKVTSRSIGLDTAASQPAESRHPPEECLLSPSRECWTKEERPAQHSSFSGFSSSDSVLRELDDGQFDQEDGVTQVTCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H8A5</accession>
    <name>A0A8B7H8A5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rho GTPase-activating protein 44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Rho-type GTPase-activating protein RICH2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RhoGAP interacting with CIP4 homologs protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ARHGAP44</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with BST2 (via cytoplasmic domain). Interacts (probably via PDZ-binding motif) with SHANK3 (via PDZ domain); the interaction takes place in dendritic spines and promotes GRIA1 exocytosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Presynapse</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020581">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632823.1">
        <property type="nucleotide sequence ID" value="XM_012777369.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H8A5"/>
    <dbReference type="Ensembl" id="ENSMICT00000002423.3">
        <property type="protein sequence ID" value="ENSMICP00000002213.3"/>
        <property type="gene ID" value="ENSMICG00000002417.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878134"/>
    <dbReference type="KEGG" id="mmur:105878134"/>
    <dbReference type="CTD" id="9912"/>
    <dbReference type="GeneTree" id="ENSGT00940000157296"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031256">
        <property type="term" value="C:leading edge membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098886">
        <property type="term" value="P:modification of dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035021">
        <property type="term" value="P:negative regulation of Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061001">
        <property type="term" value="P:regulation of dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07619">
        <property type="entry name" value="BAR_Rich2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000001">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000018">
        <property type="entry name" value="Rho GTPase activating protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047165">
        <property type="entry name" value="RHG17/44/SH3BP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130">
        <property type="entry name" value="3BP-1 RELATED RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14130:SF13">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="BAR" evidence="17">
        <location>
            <begin position="14"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="16">
        <location>
            <begin position="255"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="528"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="785"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="621"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="686"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00070278"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00076927"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
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        <source>
            <dbReference type="PROSITE" id="PS51021"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002213.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="815" mass="88698" checksum="8BCF4164C4740419" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HAQ0</accession>
    <name>A0A8B7HAQ0_MICMU</name>
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        <submittedName>
            <fullName evidence="16">Transmembrane protein 132A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TMEM132A</name>
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    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM132 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012633792.1">
        <property type="nucleotide sequence ID" value="XM_012778338.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7HAQ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000067642.1">
        <property type="protein sequence ID" value="ENSMICP00000047391.1"/>
        <property type="gene ID" value="ENSMICG00000042560.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878646"/>
    <dbReference type="KEGG" id="mmur:105878646"/>
    <dbReference type="CTD" id="54972"/>
    <dbReference type="GeneTree" id="ENSGT00940000161414"/>
    <dbReference type="OrthoDB" id="10026202at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061357">
        <property type="term" value="P:positive regulation of Wnt protein secretion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Ig_TMEM132_2nd"/>
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        <property type="entry name" value="Ig_TMEM132_4th"/>
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        <property type="entry name" value="Ig_TMEM132_5th"/>
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        <property type="entry name" value="Ig_TMEM132_6th"/>
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        <property type="entry name" value="TMEM132"/>
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        <property type="entry name" value="TMEM132_3rd"/>
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        <property type="entry name" value="TMEM132_C"/>
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    <dbReference type="InterPro" id="IPR031435">
        <property type="entry name" value="TMEM132_N"/>
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    <dbReference type="PANTHER" id="PTHR13388">
        <property type="entry name" value="DETONATOR, ISOFORM E"/>
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    </dbReference>
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        <property type="entry name" value="TRANSMEMBRANE PROTEIN 132A"/>
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    </dbReference>
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        <property type="entry name" value="Ig_TMEM132_2nd"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF16070">
        <property type="entry name" value="Ig_TMEM132_4th"/>
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    </dbReference>
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        <property type="entry name" value="Ig_TMEM132_5th"/>
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        <property type="entry name" value="Ig_TMEM132_6th"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF23039">
        <property type="entry name" value="TMEM132_3rd"/>
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    </dbReference>
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        <property type="entry name" value="TMEM132_C"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF15705">
        <property type="entry name" value="TMEM132_N"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134065" evidence="8">
        <location>
            <begin position="37"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="851"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 second Ig-like" evidence="13">
        <location>
            <begin position="124"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 cohesin-like" evidence="12">
        <location>
            <begin position="247"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein family 132 fourth" evidence="11">
        <location>
            <begin position="399"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 fifth" evidence="14">
        <location>
            <begin position="499"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 sixth" evidence="15">
        <location>
            <begin position="635"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Transmembrane protein TMEM132 C-terminal" evidence="10">
        <location>
            <begin position="821"/>
            <end position="906"/>
        </location>
    </feature>
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        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="907"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="778"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="794"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006166"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15705"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF15706"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF16070"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23039"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23481"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1026" mass="110311" checksum="5D3FD43B9288B144" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBX1</accession>
    <name>A0A8B7HBX1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SIX homeobox 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SIX6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633219.1">
        <property type="nucleotide sequence ID" value="XM_012777765.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HBX1"/>
    <dbReference type="Ensembl" id="ENSMICT00000067761.1">
        <property type="protein sequence ID" value="ENSMICP00000050370.1"/>
        <property type="gene ID" value="ENSMICG00000047804.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878374"/>
    <dbReference type="KEGG" id="mmur:105878374"/>
    <dbReference type="CTD" id="4990"/>
    <dbReference type="GeneTree" id="ENSGT00940000160091"/>
    <dbReference type="OrthoDB" id="3501850at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000046">
        <property type="entry name" value="SIX homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF12">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="128"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="190"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="246" mass="27671" checksum="537857DDD943DF27" modified="2022-01-19" version="1">MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQGSGRALRAEGEGTPEVLGVAASPAASLSSKAATSAISITSSDSECDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HCD3</accession>
    <name>A0A8B7HCD3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SLIT and NTRK like family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLITRK1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLITRK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017400">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634497.1">
        <property type="nucleotide sequence ID" value="XM_012779043.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HCD3"/>
    <dbReference type="Ensembl" id="ENSMICT00000005381.3">
        <property type="protein sequence ID" value="ENSMICP00000004906.1"/>
        <property type="gene ID" value="ENSMICG00000005389.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879075"/>
    <dbReference type="KEGG" id="mmur:105879075"/>
    <dbReference type="CTD" id="114798"/>
    <dbReference type="GeneTree" id="ENSGT00940000159810"/>
    <dbReference type="OMA" id="KICACNE"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050772">
        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000001">
        <property type="entry name" value="SLIT and NTRK-like family, member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF7">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134070" evidence="11">
        <location>
            <begin position="16"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="619"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="12">
        <location>
            <begin position="529"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="696" mass="77723" checksum="A44EFA8A1A0C1C83" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HI27</accession>
    <name>A0A8B7HI27_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Transforming growth factor beta activator LRRC33</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Negative regulator of reactive oxygen species</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NRROS</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the LRRC32/LRRC33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001050">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012635787.1">
        <property type="nucleotide sequence ID" value="XM_012780333.1"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSMICP00000050777.1"/>
        <property type="gene ID" value="ENSMICG00000049545.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879813"/>
    <dbReference type="KEGG" id="mmur:105879813"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:receptor ligand inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:transforming growth factor beta binding"/>
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        <property type="term" value="P:immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014005">
        <property type="term" value="P:microglia development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sequestering of TGFbeta in extracellular matrix"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:superoxide metabolic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.80.10.10:FF:000806">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000913">
        <property type="entry name" value="Transforming growth factor beta activator LRRC33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF30">
        <property type="entry name" value="LRRNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00054314"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00079458"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="750" mass="83248" checksum="296D982FC404E450" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HJV7</accession>
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        <submittedName>
            <fullName evidence="10">CAP-Gly domain containing linker protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLIP1</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024826">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024828">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637709.1">
        <property type="nucleotide sequence ID" value="XM_012782255.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000045498.2">
        <property type="protein sequence ID" value="ENSMICP00000040019.2"/>
        <property type="gene ID" value="ENSMICG00000001175.3"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000155122"/>
    <dbReference type="OrthoDB" id="5412539at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044354">
        <property type="term" value="C:macropinosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
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    </dbReference>
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        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CAP_GLY"/>
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    <feature type="domain" description="CAP-Gly" evidence="9">
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            <end position="274"/>
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    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
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    <evidence type="ECO:0000256" key="8">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50245"/>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRN5</accession>
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        <submittedName>
            <fullName evidence="6">Leucine zipper tumor suppressor 1</fullName>
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        <name evidence="6" type="primary">LZTS1</name>
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        <name type="scientific">Microcebus murinus</name>
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        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
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                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        </subcellularLocation>
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        <property type="nucleotide sequence ID" value="XM_012785093.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012785094.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000039465.2">
        <property type="protein sequence ID" value="ENSMICP00000031626.1"/>
        <property type="gene ID" value="ENSMICG00000001804.3"/>
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    <dbReference type="KEGG" id="mmur:105882562"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="153"/>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="598" mass="66532" checksum="E775A498BC580956" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HT14</accession>
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        <recommendedName>
            <fullName evidence="18">Disintegrin and metalloproteinase domain-containing protein 17</fullName>
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        <alternativeName>
            <fullName evidence="19">TNF-alpha-converting enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ADAM17</name>
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        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to 'shed' the extracellular domains.</text>
            <dbReference type="EC" id="3.4.24.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MAD2L1, MAPK14 and MUC1. Interacts with iRhom1/RHBDF1 and iRhom2/RHBDF2. Interacts with FRMD8 via its interaction with iRhom1/RHBDF1 and iRhom2/RHBDF2. Interacts with TSPAN8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.86" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03012151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012785691.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7HT14"/>
    <dbReference type="Ensembl" id="ENSMICT00000002387.3">
        <property type="protein sequence ID" value="ENSMICP00000002182.2"/>
        <property type="gene ID" value="ENSMICG00000002380.3"/>
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    <dbReference type="GeneID" id="105882940"/>
    <dbReference type="KEGG" id="mmur:105882940"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155443"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005138">
        <property type="term" value="F:interleukin-6 receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:metallodipeptidase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902945">
        <property type="term" value="F:metalloendopeptidase activity involved in amyloid precursor protein catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030165">
        <property type="term" value="F:PDZ domain binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043120">
        <property type="term" value="F:tumor necrosis factor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071403">
        <property type="term" value="P:cellular response to high density lipoprotein particle stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140447">
        <property type="term" value="P:cytokine precursor processing"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038134">
        <property type="term" value="P:ERBB2-EGFR signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002467">
        <property type="term" value="P:germinal center formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120163">
        <property type="term" value="P:negative regulation of cold-induced thermogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043536">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900087">
        <property type="term" value="P:positive regulation of G1/S transition of mitotic cell cycle"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010820">
        <property type="term" value="P:positive regulation of T cell chemotaxis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1903265">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002532">
        <property type="term" value="P:production of molecular mediator involved in inflammatory response"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048679">
        <property type="term" value="P:regulation of axon regeneration"/>
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        <property type="term" value="P:regulation of mast cell apoptotic process"/>
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    <dbReference type="GO" id="GO:2001222">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001666">
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0023061">
        <property type="term" value="P:signal release"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0033077">
        <property type="term" value="P:T cell differentiation in thymus"/>
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        <property type="term" value="P:wound healing, spreading of epidermal cells"/>
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        <property type="entry name" value="ZnMc_TACE_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ADAM10_ADAM17"/>
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        <property type="entry name" value="ADAM_Metalloproteinase"/>
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        <property type="entry name" value="Disintegrin_dom"/>
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        <property type="entry name" value="Disintegrin_dom_sf"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Peptidase_M12B"/>
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        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
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    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
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    <keyword evidence="9 21" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5044134167" description="Disintegrin and metalloproteinase domain-containing protein 17" evidence="24">
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            <begin position="18"/>
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        <location>
            <begin position="672"/>
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        <location>
            <begin position="223"/>
            <end position="474"/>
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        <location>
            <begin position="475"/>
            <end position="563"/>
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        <location>
            <begin position="763"/>
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        <location>
            <begin position="768"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="405"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="409"/>
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        <ligand>
            <name>Zn(2+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
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            <position position="415"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00075778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002182.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="824" mass="92929" checksum="B4FC90F62464E9A3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I7E2</accession>
    <name>A0A8B7I7E2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Peroxisomal membrane protein PEX14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PEX14</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with PEX13; forming the PEX13-PEX14 docking complex. Interacts with PEX5 (via WxxxF/Y motifs). Interacts with PEX19. Interacts with tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peroxin-14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002401">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646870.1">
        <property type="nucleotide sequence ID" value="XM_012791416.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I7E2"/>
    <dbReference type="Ensembl" id="ENSMICT00000026912.2">
        <property type="protein sequence ID" value="ENSMICP00000038910.1"/>
        <property type="gene ID" value="ENSMICG00000004575.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105886051"/>
    <dbReference type="KEGG" id="mmur:105886051"/>
    <dbReference type="CTD" id="5195"/>
    <dbReference type="GeneTree" id="ENSGT00390000015047"/>
    <dbReference type="OrthoDB" id="441517at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034453">
        <property type="term" value="P:microtubule anchoring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036250">
        <property type="term" value="P:peroxisome transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044721">
        <property type="term" value="P:protein import into peroxisome matrix, substrate release"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016561">
        <property type="term" value="P:protein import into peroxisome matrix, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000296">
        <property type="entry name" value="Peroxisomal membrane protein PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025655">
        <property type="entry name" value="PEX14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006785">
        <property type="entry name" value="Pex14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23058:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04695">
        <property type="entry name" value="Pex14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peroxisome membrane anchor protein Pex14p N-terminal" evidence="18">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="265"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="376" mass="41100" checksum="CD5BEF2639CB3AAF" modified="2022-01-19" version="1">MASSEQAEQPSQPSSTPGSDNVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLIVGGREDRKQLERMEASLSELTGSVAQTVTQLQTTLASVQELLIQQQQKVQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRLEVQGEEEKREDKEDEEDEDDDVSHVDEEDCLGVQREDRRGGDGQINEQVEKLRRPEGASNENERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I7I4</accession>
    <name>A0A8B7I7I4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">F-box/LRR-repeat protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">F-box and leucine-rich repeat protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FBXL7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase. Interacts with BIRC5; this interaction allows BIRC5 to be polyubiquitinated by the SCF(FBXL7) E3 ubiquitin-protein ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FBXL7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016125">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016127">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016129">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645713.1">
        <property type="nucleotide sequence ID" value="XM_012790259.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I7I4"/>
    <dbReference type="Ensembl" id="ENSMICT00000010530.3">
        <property type="protein sequence ID" value="ENSMICP00000009587.2"/>
        <property type="gene ID" value="ENSMICG00000010535.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885363"/>
    <dbReference type="CTD" id="23194"/>
    <dbReference type="GeneTree" id="ENSGT00940000158009"/>
    <dbReference type="OrthoDB" id="423607at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22120">
        <property type="entry name" value="F-box_FBXL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000122">
        <property type="entry name" value="F-box/LRR-repeat protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000126">
        <property type="entry name" value="F-box/LRR-repeat protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000018">
        <property type="entry name" value="F-box/LRR-repeat protein 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF50">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="17">
        <location>
            <begin position="111"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009587.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="491" mass="54580" checksum="DE1D4EB673FA5093" modified="2022-01-19" version="1">MGANNGKQYGSEGKGSSSISSDVSSSTDHTPTKAQKNVATSEDSDLSMRTLSTPSPALICPPNLPGFQNGRGSSTSSSSITGETVAMVHSPPPTRLTHPLIRLASRPQKEQASIDRLPDQAMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLTRRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEGLRYLVIYCTSIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCGKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQMLNVQDCEVSVEALRFVKRHCKRCVIEHTNPAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XCG6</accession>
    <name>A0A8B7XCG6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dedicator of cytokinesis 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DOCK8</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014392">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014393">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014395">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014396">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014397">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014398">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144880.1">
        <property type="nucleotide sequence ID" value="XM_020289291.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039870.2">
        <property type="protein sequence ID" value="ENSMICP00000029663.2"/>
        <property type="gene ID" value="ENSMICG00000008267.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855901"/>
    <dbReference type="KEGG" id="mmur:105855901"/>
    <dbReference type="CTD" id="81704"/>
    <dbReference type="GeneTree" id="ENSGT00940000155876"/>
    <dbReference type="OrthoDB" id="47328at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031256">
        <property type="term" value="C:leading edge membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990869">
        <property type="term" value="P:cellular response to chemokine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036336">
        <property type="term" value="P:dendritic cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001771">
        <property type="term" value="P:immunological synapse formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061485">
        <property type="term" value="P:memory T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070233">
        <property type="term" value="P:negative regulation of T cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903905">
        <property type="term" value="P:positive regulation of establishment of T cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000406">
        <property type="term" value="P:positive regulation of T cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08696">
        <property type="entry name" value="C2_Dock-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11701">
        <property type="entry name" value="DHR2_DOCK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000002">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000022">
        <property type="entry name" value="Dedicator of cytokinesis protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037808">
        <property type="entry name" value="C2_Dock-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF74">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 DOCK-type" evidence="4">
        <location>
            <begin position="560"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="5">
        <location>
            <begin position="1633"/>
            <end position="2067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029663.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2100" mass="238913" checksum="BE968FF17A319DC5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5ULR3</accession>
    <name>A0A8C5ULR3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transmembrane p24 trafficking protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMED6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024098">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5ULR3"/>
    <dbReference type="Ensembl" id="ENSMICT00000001485.3">
        <property type="protein sequence ID" value="ENSMICP00000001355.2"/>
        <property type="gene ID" value="ENSMICG00000001486.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010961"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034796185" evidence="10">
        <location>
            <begin position="22"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001355.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="236" mass="27317" checksum="BB17E82F22C23E33" modified="2022-01-19" version="1">MFPLLFGAGLAVLNLVTSASSQKTEPLSGSGEQLLFRGADRHDFAIMIPPGGTECFWQFAHQTGYFYFSYEVQRTVGMSHDRHVVATAHTPQGLLIGTSQDVRGQINFSTQETGFYELCLKNQQNHFGSVQVYLNFGVFYEEPEMDHKQNERKQLNDTLDAIEQSTRKVQNNIFHMWRYYNFARMRKMADFFLLQSNYKDERTQSLLIILFWDPAAVFLKRLFNVPTTIDTKKPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5ULS3</accession>
    <name>A0A8C5ULS3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Integrin subunit alpha 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ITGA11</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Membrane</location>
            <topology evidence="1 17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004847">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
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    <keyword evidence="9 17" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="14 17" id="KW-0675">Receptor</keyword>
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    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
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    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
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        <source>
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    <sequence length="1189" mass="132659" checksum="0FE5D97A3D0806BB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5URN6</accession>
    <name>A0A8C5URN6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Matrix metallopeptidase 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MMP10</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012770514.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5URN6"/>
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        <property type="protein sequence ID" value="ENSMICP00000005730.2"/>
        <property type="gene ID" value="ENSMICG00000006282.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874562"/>
    <dbReference type="KEGG" id="mmur:105874562"/>
    <dbReference type="CTD" id="4319"/>
    <dbReference type="GeneTree" id="ENSGT00940000163375"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
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    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF270">
        <property type="entry name" value="STROMELYSIN-2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
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    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
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    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
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    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
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    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
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        <property type="entry name" value="HEMOPEXIN"/>
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    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 23" id="KW-0732">Signal</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149877" evidence="23">
        <location>
            <begin position="18"/>
            <end position="489"/>
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    <feature type="domain" description="Peptidase metallopeptidase" evidence="24">
        <location>
            <begin position="105"/>
            <end position="264"/>
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    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="286"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="336"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="384"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="20">
        <location>
            <begin position="90"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="17">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="158"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="168"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="170"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
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            <position position="176"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>3</label>
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            <position position="183"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
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        <ligand>
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            <name>Ca(2+)</name>
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            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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            <name>Zn(2+)</name>
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        <ligand>
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        <ligand>
            <name>Ca(2+)</name>
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        <ligand>
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        <ligand>
            <name>Ca(2+)</name>
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        </ligand>
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        <location>
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        <ligand>
            <name>Ca(2+)</name>
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        <ligand>
            <name>Ca(2+)</name>
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            <position position="371"/>
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            <begin position="289"/>
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            <dbReference type="ARBA" id="ARBA00004498"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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            <dbReference type="ARBA" id="ARBA00023145"/>
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            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="SMART" id="SM00235"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="489" mass="55869" checksum="CA721873CA58D2E7" modified="2022-01-19" version="1">MKHLAILVLLCLSVCSAYTLKRGAKEEATSVDLARKYLEDYYNLAKDVKMFVRRKDSGSVVKKIREMQKFLGLEVTGKLDSDTLEVIRKPRCGVPDVGHFTTFPGTPKWRKTHLTYRIVNYTPDLPRDAVDSAIERALKVWEEVTPLTFSRLYEGEADIMISFAVGEHGDFFPFYGPGGSLAHAYPPGPGFHGDVHFDDDENWTEDASGTNLFLVAVHELGHSLGLSHSANVKAVMHPLYKSTDLAQFRLSQDDVDGIQSLYGPPPAFSDDTPVPTKPVPPRPVTPAKCDPALSFDAVSTLRGEVLFFKDRYFWRKTRWNPEPEFHLISTFWPSLPSHLDAAYEVNSKDTVFIFKGNQFWAVRGSEIQAGYPRRIHTLGFPPTIRKIDAALSDKDKKKTYFFVEDKYWRFDENSQSMEHGFPRLIADDFPGVEPKVDAVFQAFGFFYFFSGSSQFEFDPNARMVTHIWKSNSWLRCQARQRKDRHRHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5URX3</accession>
    <name>A0A8C5URX3_MICMU</name>
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        <recommendedName>
            <fullName evidence="18">Regulator of microtubule dynamics protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein FAM82A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Protein FAM82C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">RMDN3</name>
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    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB. Interacts (via FFAT motif) with MOSPD2 (via MSP domain). Interacts (via phosphorylated FFAT motif) with MOSPD2, VAPA and VAPB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the RMDN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004603">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004605">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004607">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621891.1">
        <property type="nucleotide sequence ID" value="XM_012766437.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5URX3"/>
    <dbReference type="Ensembl" id="ENSMICT00000005943.3">
        <property type="protein sequence ID" value="ENSMICP00000005421.2"/>
        <property type="gene ID" value="ENSMICG00000005945.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872452"/>
    <dbReference type="KEGG" id="mmur:105872452"/>
    <dbReference type="CTD" id="55177"/>
    <dbReference type="GeneTree" id="ENSGT00950000182992"/>
    <dbReference type="OrthoDB" id="512473at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097431">
        <property type="term" value="C:mitotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044232">
        <property type="term" value="C:organelle membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000310">
        <property type="entry name" value="Regulator of microtubule dynamics protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049039">
        <property type="entry name" value="RMD1-3_a_helical_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16056:SF18">
        <property type="entry name" value="REGULATOR OF MICROTUBULE DYNAMICS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21033">
        <property type="entry name" value="RMD1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="168"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005421.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="471" mass="52170" checksum="4BD779FC8BD162F1" modified="2022-01-19" version="1">MSRLGSLGGARAGLGLLLGTAAGLGFLCVLYSRRWKRTQRHGRSQSLPNSLDYTQTSEPGRQVMLLRAVPGEAGDAAVLPSLPQEGQEKVLDRLDFVLTSLVALRREVEELRSSLQGLAGEIVGEVRSHMEENQRVARRRRFPFARERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDYERDSDKESEDGEDEVSCETVKMGRKDSLDLDMEAEAASGLGPSALEAGGSLEDVLPLLRQADELHRGDEQGKREGFQLLLNNKLAYGSRQDFLWRLARAYSDICELTEEVSEKKSYALNGKEEAEAALEKGDESAECHQWYAVLCGQLAEHEGIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALSENPLSATVQDALQSFLKAEELQPGFSKAGRVYISKCYRELGNNSEARRWMKLALELPDVTKEDSAFQKDLEELEVILGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVV0</accession>
    <name>A0A8C5UVV0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC105875531</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03024431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVV0"/>
    <dbReference type="Ensembl" id="ENSMICT00000009258.3">
        <property type="protein sequence ID" value="ENSMICP00000008432.2"/>
        <property type="gene ID" value="ENSMICG00000009260.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158564"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00312">
        <property type="entry name" value="Esterase_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000011">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="17"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008432.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="481" mass="53288" checksum="1ECA69F8D59F671D" modified="2022-01-19" version="1">MCPQDPVGGQVVSELITNRKENIPLTFSEDCLYLNIYTPADLRENSRLPVMVWIYGGGLVLGGASTYDGLALSARENVVVVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHQAISESGVALTYALLKKDNIKLLAEQVAVSAGCKTTTSAVMVHCLRQKTEEELLEATLKMKFFTIDFLGDPRKGHPFLPTVVDGVVLPKSPEEILAEKSFNTVPYIVGINKQEFGWILPTLMGYPLSEGKLDQRTATSLLWKSYPVTGIPEELTLVAIKEYLGGTDDPVKKKDRFLDLMADVMFGVPSVIVARQHRDSGAPTYMYEFRYRPSFSSDMKPETVRGDHADEIFSVFGAPFLKEGASDEEIQLSKTVMKFWANFARNGNPNGEGLPHWPEYDKKEGYLQIDVPIQEAQKLKDKEVDFWTKLLDTDAAEKAPQKGHTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UW67</accession>
    <name>A0A8C5UW67_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AT-rich interactive domain-containing protein 3</fullName>
            <shortName evidence="8">ARID domain-containing protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ARID3A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UW67"/>
    <dbReference type="Ensembl" id="ENSMICT00000010145.3">
        <property type="protein sequence ID" value="ENSMICP00000009238.3"/>
        <property type="gene ID" value="ENSMICG00000010143.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160899"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16878">
        <property type="entry name" value="ARID_ARID3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000006">
        <property type="entry name" value="AT-rich interactive domain-containing protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045147">
        <property type="entry name" value="ARI3A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023334">
        <property type="entry name" value="REKLES_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348:SF1">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15348">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN ARID DOMAIN- CONTAINING PROTEIN DEAD RINGER PROTEIN B-CELL REGULATOR OF IGH TRANSCRIPTION BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51486">
        <property type="entry name" value="REKLES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ARID" evidence="10">
        <location>
            <begin position="244"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="REKLES" evidence="11">
        <location>
            <begin position="450"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="571"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009238.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="606" mass="64034" checksum="A6EBC4B7727BCBBF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXN5</accession>
    <name>A0A8C5UXN5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">eIF-2-alpha kinase GCN2</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Eukaryotic translation initiation factor 2-alpha kinase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">GCN2-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">EIF2AK4</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 35">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 35">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homodimer; homodimerization is important for kinase activation by uncharged tRNAs. Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with DNAJC3; this interaction inhibits EIF2AK4/GCN2 kinase activity during endoplasmic reticulum (ER), hypothermic and amino acid-starving stress conditions. Interacts with MAP3K20; activates EIF2AK4/GCN2 kinase activity in response to moderate ribotoxic stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03004588">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004589">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004590">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004591">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
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        <name type="synonym">Lemur murinus</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2 21">Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 21">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 21">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 21">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="7 21"/>
    <dbReference type="EMBL" id="ABDC03003220">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623361.1">
        <property type="nucleotide sequence ID" value="XM_012767907.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623362.1">
        <property type="nucleotide sequence ID" value="XM_012767908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UY95"/>
    <dbReference type="Ensembl" id="ENSMICT00000007946.3">
        <property type="protein sequence ID" value="ENSMICP00000007238.2"/>
        <property type="gene ID" value="ENSMICG00000007946.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000035369.2">
        <property type="protein sequence ID" value="ENSMICP00000021334.1"/>
        <property type="gene ID" value="ENSMICG00000007946.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067095.1">
        <property type="protein sequence ID" value="ENSMICP00000040866.1"/>
        <property type="gene ID" value="ENSMICG00000007946.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873190"/>
    <dbReference type="KEGG" id="mmur:105873190"/>
    <dbReference type="CTD" id="80308"/>
    <dbReference type="GeneTree" id="ENSGT00390000007266"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047884">
        <property type="term" value="F:FAD diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006771">
        <property type="term" value="P:riboflavin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000113">
        <property type="entry name" value="FAD synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000007">
        <property type="entry name" value="FAD synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012183">
        <property type="entry name" value="FAD_synth_MoaB/Mog-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056596">
        <property type="entry name" value="FLAD1_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24102">
        <property type="entry name" value="FLAD1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036620">
        <property type="entry name" value="MPTbdFAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 21" id="KW-0274">FAD</keyword>
    <keyword evidence="10 21" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 21" id="KW-0288">FMN</keyword>
    <keyword evidence="14 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 21" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="22">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR036620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007238.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="490" mass="54383" checksum="1CCC25D69EF1B633" modified="2022-01-19" version="1">MASRASELPPGRSVTAGIIIVGDEILKGHTQDTNTYFLCRTLRSLGVQVCRVSVVPDEVATIAAEVTSFSSRFTHVLTAGGIGPTHDDVTFEAVAKAFGDELKPHPELEAATKALGGEGLEKLSLVPSSARLHYGTDPRTGRPFRFPLVSVRNVYLFPGIPELLQRVLEGLKGLFQNTAVQFHSRELYVAANEASIASILAEAQTHFGHRLSLGSYPDWGSNYYQVKLTLDSEEEGPLEECMAYLTARLPQGSLIPYMPNTVEQASEAVYKLAESGSSLGKKVASALQTIETALARYNLTQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRGISPFPELEQFLQDTIKRYNLQVLEAEGNMKQALCELQAQHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPSFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSQENTVRNPALKCLSPGGRLTYRPAYLLENEDEERNSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V0H9</accession>
    <name>A0A8C5V0H9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cell division cycle 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CDC16</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018095">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V0H9"/>
    <dbReference type="Ensembl" id="ENSMICT00000012600.3">
        <property type="protein sequence ID" value="ENSMICP00000011475.3"/>
        <property type="gene ID" value="ENSMICG00000012596.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182950"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="445"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011475.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="587" mass="67578" checksum="D384F7627CB2B7C4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V4C7</accession>
    <name>A0A8C5V4C7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein Wnt</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">WNT3A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ligand for members of the frizzled family of seven transmembrane receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
            <location evidence="1 11">Extracellular space</location>
            <location evidence="1 11">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Wnt family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017942">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017943">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V4C7"/>
    <dbReference type="Ensembl" id="ENSMICT00000010667.3">
        <property type="protein sequence ID" value="ENSMICP00000009720.3"/>
        <property type="gene ID" value="ENSMICG00000010671.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160510"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005109">
        <property type="term" value="F:frizzled binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19335">
        <property type="entry name" value="Wnt_Wnt3_Wnt3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2460.20:FF:000001">
        <property type="entry name" value="Wnt homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005817">
        <property type="entry name" value="Wnt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009141">
        <property type="entry name" value="Wnt3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043158">
        <property type="entry name" value="Wnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018161">
        <property type="entry name" value="Wnt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027:SF88">
        <property type="entry name" value="PROTEIN WNT-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12027">
        <property type="entry name" value="WNT RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00110">
        <property type="entry name" value="wnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01843">
        <property type="entry name" value="WNT3PROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01349">
        <property type="entry name" value="WNTPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00097">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00246">
        <property type="entry name" value="WNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0879">Wnt signaling pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009720.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="346" mass="38490" checksum="AC448736760495FE" modified="2022-01-19" version="1">QTRRIWGALLGVTTGGKASLAVGPQYSSLGTQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKMGIQECQHQFRGRRWNCTTVNNSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGAATICGCSSRHQGSPGEGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAVGDFLKDKYDSASEMLVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARTEQRREKCRCVFHWCCYVSCQECTRVYDVHTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5Q7</accession>
    <name>A0A8C5V5Q7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vinculin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Metavinculin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">VCL</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <location evidence="4">Sarcolemma</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019036">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5Q7"/>
    <dbReference type="Ensembl" id="ENSMICT00000011736.3">
        <property type="protein sequence ID" value="ENSMICP00000010683.3"/>
        <property type="gene ID" value="ENSMICG00000011725.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="Proteomes" id="UP000694394">
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="term" value="C:podosome ring"/>
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        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:actin filament binding"/>
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        <property type="term" value="F:alpha-catenin binding"/>
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        <property type="term" value="F:dystroglycan binding"/>
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        <property type="term" value="F:structural molecule activity"/>
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        <property type="entry name" value="Vinculin b"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
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        <property type="entry name" value="Vinculin, Vh2 four-helix bundle"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
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        <property type="entry name" value="Vinculin"/>
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    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
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        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
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        <property type="entry name" value="VINCULIN"/>
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    </dbReference>
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        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00806">
        <property type="entry name" value="VINCULIN"/>
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    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
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        <property type="entry name" value="VINCULIN_1"/>
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    <dbReference type="PROSITE" id="PS00664">
        <property type="entry name" value="VINCULIN_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="12" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="13" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="862"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="365"/>
            <end position="392"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="865"/>
            <end position="881"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
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        <source>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00024757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010683.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1139" mass="124355" checksum="FF15E41C8220BB68" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6D7</accession>
    <name>A0A8C5V6D7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Family with sequence similarity 234 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAM234B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FAM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010240">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010241">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6D7"/>
    <dbReference type="Ensembl" id="ENSMICT00000014798.3">
        <property type="protein sequence ID" value="ENSMICP00000013493.3"/>
        <property type="gene ID" value="ENSMICG00000014794.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063694"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF25">
        <property type="entry name" value="PROTEIN FAM234B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="8">
        <location>
            <begin position="152"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="8">
        <location>
            <begin position="326"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013493.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="595" mass="64154" checksum="95576E6D33A989D0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9G6</accession>
    <name>A0A8C5V9G6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Osteoclast associated Ig-like receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OSCAR</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9G6"/>
    <dbReference type="Ensembl" id="ENSMICT00000037464.2">
        <property type="protein sequence ID" value="ENSMICP00000017852.2"/>
        <property type="gene ID" value="ENSMICG00000028728.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286974"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038064">
        <property type="term" value="F:collagen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002764">
        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000033">
        <property type="entry name" value="Killer cell immunoglobulin-like receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000049">
        <property type="entry name" value="Leukocyte immunoglobulin-like receptor subfamily B member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF186">
        <property type="entry name" value="OSTEOCLAST-ASSOCIATED IMMUNOGLOBULIN-LIKE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034613890" evidence="8">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017852.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="251" mass="27179" checksum="C25B6A43C68E033D" modified="2022-01-19" version="1">MALVLILQLLSLFPPASYSKPWLGVQPAAVVTPGVNVTLRCRAPQVAWRFALFKPGETGPLLFRDVSSELAEFFLEEVTLAQGGSYCCSYRRPDWKPGVWSQPSDELELLVTEQLPRPSLVALPGPVVARGANVSLRCAGRVRGMSFALYREGVAAPLQFRDSAQRWADFPLPGARAPGTYSCYYHTPSAPYVLSQRSEPLVISSEDSGSSDYTRGNLVRLGLAGLVLISLGALVAFDWRSQKRAPGGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9P1</accession>
    <name>A0A8C5V9P1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Chloride intracellular channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="37" type="primary">CLIC4</name>
    </gene>
    <organism evidence="37 38">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="37" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="37" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="37" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="34">In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>choline(out) = choline(in)</text>
            <dbReference type="Rhea" id="RHEA:32751"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>nitrate(in) = nitrate(out)</text>
            <dbReference type="Rhea" id="RHEA:34923"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>thiocyanate(in) = thiocyanate(out)</text>
            <dbReference type="Rhea" id="RHEA:75347"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
            <location evidence="5">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="32">Cytoplasmic vesicle membrane</location>
            <topology evidence="32">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="35">Membrane</location>
            <topology evidence="35">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="35">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="35">Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 35">Belongs to the chloride channel CLIC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606047.1">
        <property type="nucleotide sequence ID" value="XM_012750593.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9P1"/>
    <dbReference type="SMR" id="A0A8C5V9P1"/>
    <dbReference type="Ensembl" id="ENSMICT00000043474.2">
        <property type="protein sequence ID" value="ENSMICP00000018527.1"/>
        <property type="gene ID" value="ENSMICG00000038442.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863489"/>
    <dbReference type="KEGG" id="mmur:105863489"/>
    <dbReference type="CTD" id="25932"/>
    <dbReference type="GeneTree" id="ENSGT00940000155017"/>
    <dbReference type="OrthoDB" id="1935530at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045177">
        <property type="term" value="C:apical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="528" mass="58974" checksum="FBA3E9F8AB36DF58" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDV2</accession>
    <name>A0A8C5VDV2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">STEAP family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">STEAP1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STEAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015456">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635038.1">
        <property type="nucleotide sequence ID" value="XM_012779584.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDV2"/>
    <dbReference type="Ensembl" id="ENSMICT00000008957.3">
        <property type="protein sequence ID" value="ENSMICP00000008157.2"/>
        <property type="gene ID" value="ENSMICG00000008961.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000041186.2">
        <property type="protein sequence ID" value="ENSMICP00000016461.1"/>
        <property type="gene ID" value="ENSMICG00000008961.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879380"/>
    <dbReference type="CTD" id="26872"/>
    <dbReference type="GeneTree" id="ENSGT00390000008042"/>
    <dbReference type="OrthoDB" id="550646at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051267">
        <property type="entry name" value="STEAP_metalloreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239">
        <property type="entry name" value="DUDULIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14239:SF3">
        <property type="entry name" value="METALLOREDUCTASE STEAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ferric oxidoreductase" evidence="7">
        <location>
            <begin position="119"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="338" mass="39811" checksum="9FF28FDF8DB3303F" modified="2022-01-19" version="1">MENTKDITNQEELWKMKPRGDLEDDAYLNKDAGETTMLKRPVLSHLHQTAHVDEFDCPSELQHKQRFFPKWHLPMKVAAIISSLTFLYTLLREIIYPLTFDKQYFYKIPILVINKVLPMVSITLLALVYLPGVIAAVVQLHNGTKYKKFPHWLDRWMLTRKQFGLLSFFFAVLHALYSLSYPMRQSYRYKLLQWTYQQVKQNKEDAWIEHDVWRMEIYVSLGIMGLAILALLALTSIPSVSNSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWVDKEQFIWYTPPTFMIAVFLPIVVLICKGILFLPCLRKKIMKIRRGWEDVAKINRIEMSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEI8</accession>
    <name>A0A8C5VEI8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">ADP-ribosylation factor-like protein 2-binding protein</fullName>
            <shortName evidence="13">ARF-like 2-binding protein</shortName>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
            <location evidence="1 13">Cytoskeleton</location>
            <location evidence="1 13">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
            <location evidence="3 13">Cytoskeleton</location>
            <location evidence="3 13">Microtubule organizing center</location>
            <location evidence="3 13">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the ARL2BP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VEI8"/>
    <dbReference type="Ensembl" id="ENSMICT00000032985.2">
        <property type="protein sequence ID" value="ENSMICP00000021130.2"/>
        <property type="gene ID" value="ENSMICG00000037106.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015052"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1520.10">
        <property type="entry name" value="ADP-ribosylation factor-like 2-binding protein, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038849">
        <property type="entry name" value="ARL2BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023379">
        <property type="entry name" value="BART_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042541">
        <property type="entry name" value="BART_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15487:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11527">
        <property type="entry name" value="ARL2_Bind_BART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 13" id="KW-0969">Cilium</keyword>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BART" evidence="14">
        <location>
            <begin position="24"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021130.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="132" mass="15064" checksum="87449369CC43337A" modified="2022-01-19" version="1">MDAVEEESFALPFSSASDAEFDAVQEFEDTEENKLTYTPIFNEYISLVEKYIEEQLPERIPGFNTAAFTTTLQHHKDEVAGDIFDMLLTLTDFLAFKEMFLDYRAEKRSSGLVVTSLCKSSSMPTSQNNLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VF09</accession>
    <name>A0A8C5VF09_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">F-box protein 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FBXO31</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023352">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VF09"/>
    <dbReference type="Ensembl" id="ENSMICT00000026957.2">
        <property type="protein sequence ID" value="ENSMICP00000018438.1"/>
        <property type="gene ID" value="ENSMICG00000007352.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001368"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031571">
        <property type="term" value="P:mitotic G1 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901797">
        <property type="term" value="P:negative regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="358" mass="40769" checksum="D3E6520C430CDF78" modified="2022-01-19" version="1">MYLPPHDPHVDDPMRFKPLFRIHLMERKSATVECMYGHKGPHNGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPEDLIKPGLFKGTYGSHGLEIVMLSFHGWRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDVENLRNFNELSRIVLEVRERVRQEQQEGGREAGEGHGHQGSREPPPPSKELDAAPAKDSGEPGDAAAAGEQSAQSGQGQPFVLPAGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VGJ9</accession>
    <name>A0A8C5VGJ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105864539</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VGJ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000009894.3">
        <property type="protein sequence ID" value="ENSMICP00000021906.1"/>
        <property type="gene ID" value="ENSMICG00000009900.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244869"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="39"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="301" mass="34249" checksum="E6304CE92CF89E24" modified="2022-01-19" version="1">MRNVSAVTEFILLGIPHTEGLQTMLFVLFLSFYIFTLMGNLLILLAIVSSTRLHTPMYFFLCKLSVFDIFFPSVSSPKMLFYLSGNSRTISYAGCVSQLFFYHFLGCTECFLYTVMAYDRFVAICYPLRYTIIMSHRVCTILATGTSFFGCIQATFLTTLTFQLPYCGPNEVDYYFCDIPVMLKLMVGFISVGLMPLSCFLLILTSYTCIVCSILQIQSTEGRRRAFSTCSAHLTAILLSFMPVVLIYLQPTPNPWLNATVQVLNNLVTPMLNPLIYSLRNKEVKYSLRKVLQQVAFFPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VGX5</accession>
    <name>A0A8C5VGX5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAG cochaperone 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BAG4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03023932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023933">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VGX5"/>
    <dbReference type="Ensembl" id="ENSMICT00000029045.2">
        <property type="protein sequence ID" value="ENSMICP00000020807.2"/>
        <property type="gene ID" value="ENSMICG00000046026.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158936"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903215">
        <property type="term" value="P:negative regulation of protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010763">
        <property type="term" value="P:positive regulation of fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051496">
        <property type="term" value="P:positive regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00264">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51035">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="2">
        <location>
            <begin position="349"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020807.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="415" mass="45181" checksum="116117AD073ED2EC" modified="2022-01-19" version="1">MSALRRSGYGPSDGPSYGRYYGSGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPTETTWPGEGEGGDGYYPSGGTWPEPGRAGGNHQEQPPYPSYNSNYWNSAARPRAPYPSTYPVRPDLQGQSLNSYTNGTNYSTEVPSTYRSPGDSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPASQNPGVTLPHYPYGDGNPSVPQSGPPVRPQEDAWASGAYGMGARCPWPAAAPSAPPGNPYMTESASPWPGSGSPRPPPSPPLQQPKDSSYPYSQSDQGMNQHNFPCSVHQYESSGTANNDNSDLTDSQVQYSAEPQLYGNTTNEHPSNQDQSNNVPEECLSSDDGTPQVLKNHTCAGKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSDSVRQARKEIQAILEKLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VGY3</accession>
    <name>A0A8C5VGY3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">A-kinase anchoring protein 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AKAP13</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03013654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013655">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013657">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000041144.2">
        <property type="protein sequence ID" value="ENSMICP00000022915.2"/>
        <property type="gene ID" value="ENSMICG00000013618.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154146"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051018">
        <property type="term" value="F:protein kinase A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071875">
        <property type="term" value="P:adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20878">
        <property type="entry name" value="C1_AKAP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13392">
        <property type="entry name" value="PH_AKAP13"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VIG6</accession>
    <name>A0A8C5VIG6_MICMU</name>
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            <fullName evidence="22">Vitamin D 25-hydroxylase</fullName>
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            <fullName evidence="23">Cytochrome P450 2R1</fullName>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">A cytochrome P450 monooxygenase involved in activation of vitamin D precursors. Catalyzes hydroxylation at C-25 of both forms of vitamin D, vitamin D(2) and D(3) (calciol). Can metabolize vitamin D analogs/prodrugs 1alpha-hydroxyvitamin D(2) (doxercalciferol) and 1alpha-hydroxyvitamin D(3) (alfacalcidol) forming 25-hydroxy derivatives. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1alpha-hydroxyvitamin D2 + reduced [NADPH--hemoprotein reductase] + O2 = 1alpha,25-dihydroxyvitamin D2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46584"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:4712"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:86320"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:46585"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alfacalcidol + reduced [NADPH--hemoprotein reductase] + O2 = calcitriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49272"/>
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        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:49273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>calciol + reduced [NADPH--hemoprotein reductase] + O2 = calcidiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32903"/>
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            <dbReference type="EC" id="1.14.14.24"/>
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            <dbReference type="Rhea" id="RHEA:32904"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>vitamin D2 + reduced [NADPH--hemoprotein reductase] + O2 = 25-hydroxyvitamin D2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46580"/>
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        </reaction>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 24">
            <name>heme</name>
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    </comment>
    <comment type="pathway">
        <text evidence="20">Hormone biosynthesis; vitamin D biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 25">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.24" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03006353">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VIG6"/>
    <dbReference type="Ensembl" id="ENSMICT00000030693.2">
        <property type="protein sequence ID" value="ENSMICP00000019108.2"/>
        <property type="gene ID" value="ENSMICG00000031499.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105879993"/>
    <dbReference type="CTD" id="120227"/>
    <dbReference type="VGNC" id="VGNC:80534">
        <property type="gene designation" value="CYP2R1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158305"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902271">
        <property type="term" value="F:D3 vitamins binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:vitamin D3 25-hydroxylase activity"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:organic acid metabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:xenobiotic metabolic process"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="vitamin D 25-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cyt_P450"/>
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        <property type="entry name" value="Cyt_P450_CS"/>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
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    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
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        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF48">
        <property type="entry name" value="VITAMIN D 25-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 24 25" id="KW-0349">Heme</keyword>
    <keyword evidence="11 24 25" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 25" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="24">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059364"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060543"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066438"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00069698"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083017"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019108.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="VGNC" id="VGNC:80534"/>
        </source>
    </evidence>
    <sequence length="526" mass="59853" checksum="4AB628D00B8B2E99" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VKC4</accession>
    <name>A0A8C5VKC4_MICMU</name>
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        <submittedName>
            <fullName evidence="6">Tripartite motif containing 44</fullName>
        </submittedName>
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        <name evidence="6" type="primary">TRIM44</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03006234">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012738760.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000034464.2">
        <property type="protein sequence ID" value="ENSMICP00000022106.1"/>
        <property type="gene ID" value="ENSMICG00000008587.3"/>
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    <dbReference type="KEGG" id="mmur:105856836"/>
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    <dbReference type="GeneTree" id="ENSGT00440000034605"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0061944">
        <property type="term" value="P:negative regulation of protein K48-linked ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001961">
        <property type="term" value="P:positive regulation of cytokine-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRIM/RBCC"/>
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    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
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    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
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    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="1 3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="174"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="165"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="344"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50119"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="344" mass="38356" checksum="76701608EA9756AE" modified="2022-01-19" version="1">MASGVGAAFEELPHDGTCDECEPDEAPGAEEVCRECGFCYCRRHAEAHRQKFLSHHLAEYVHGAQAWTSRAGGEGAGKEEVEAKVEPERDIESEAGEESESEEESESEEESETEEESEDESDDESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLCPVIGAHQGHQLSTLDEAFEELRSKDSGGLKAAMIELVERLKFKSSDPKVTRDQMKVFIQQEFKKVQKVIADEEQKALHLVDIQEAMATAHVTEILADIQSHMDRLMTQMAQAKEQLDTSNESAEPKAEGDEEGPSGASEEEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLB5</accession>
    <name>A0A8C5VLB5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005751">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLB5"/>
    <dbReference type="Ensembl" id="ENSMICT00000035823.2">
        <property type="protein sequence ID" value="ENSMICP00000020760.2"/>
        <property type="gene ID" value="ENSMICG00000046422.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157820"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020760.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="77" mass="8651" checksum="F3042B70397E5681" modified="2022-01-19" version="1">MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDPQRLIFAGKQLEDGRTLSDYNIQKESTMHLVLRLRGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLL9</accession>
    <name>A0A8C5VLL9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Transmembrane prolyl 4-hydroxylase</fullName>
            <ecNumber evidence="17">1.14.11.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Hypoxia-inducible factor prolyl hydroxylase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">P4HTM</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-prolyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:48400"/>
            <dbReference type="Rhea" id="RHEA-COMP:12093"/>
            <dbReference type="Rhea" id="RHEA-COMP:12094"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.14.11.29" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03018191">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLL9"/>
    <dbReference type="Ensembl" id="ENSMICT00000036767.2">
        <property type="protein sequence ID" value="ENSMICP00000020940.2"/>
        <property type="gene ID" value="ENSMICG00000007843.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014570"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160082">
        <property type="term" value="F:hypoxia-inducible factor-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000141">
        <property type="entry name" value="transmembrane prolyl 4-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000008">
        <property type="entry name" value="transmembrane prolyl 4-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="24">
        <location>
            <begin position="309"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020940.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="501" mass="56488" checksum="A8B6AEE0BE24C3C2" modified="2022-01-19" version="1">MAAAAAGQRPGTAAAGEASSPQWALPEHRRERAAAGLRDGEDAPVRPLCKPRGICSRAYFLVLMVFVHLYLGNVLALLLFVHYSNGDESTDPGPQRRAQGPGPAPTLGPLARLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIQLAQLKGLQRSQILPTEEYEEAMSTMQVSQLDLFQLLDQNHDGRLQLREVLAQTRLGNGRWMTPENIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHVMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGADSQPEWALDRAYRDTRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLY5</accession>
    <name>A0A8C5VLY5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 53 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">VPS53</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54. Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin. EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network. Interacts with VPS50 in an EIPR1-independent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020357">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020359">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596023.1">
        <property type="nucleotide sequence ID" value="XM_012740569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLY5"/>
    <dbReference type="Ensembl" id="ENSMICT00000048361.2">
        <property type="protein sequence ID" value="ENSMICP00000023089.1"/>
        <property type="gene ID" value="ENSMICG00000009328.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105857874"/>
    <dbReference type="CTD" id="55275"/>
    <dbReference type="GeneTree" id="ENSGT00390000015165"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090119">
        <property type="term" value="P:vesicle-mediated cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000001">
        <property type="entry name" value="vacuolar protein sorting-associated protein 53 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.950">
        <property type="entry name" value="Methyl-accepting chemotaxis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="16">
        <location>
            <begin position="41"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Vps53 C-terminal" evidence="17">
        <location>
            <begin position="694"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="799"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00063964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="832" mass="94442" checksum="C81D61A9B37FFD2F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMR0</accession>
    <name>A0A8C5VMR0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MENTAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STARD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMR0"/>
    <dbReference type="Ensembl" id="ENSMICT00000034955.2">
        <property type="protein sequence ID" value="ENSMICP00000024234.2"/>
        <property type="gene ID" value="ENSMICG00000034311.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155476"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140284">
        <property type="term" value="C:endoplasmic reticulum-endosome membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030301">
        <property type="term" value="P:cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099044">
        <property type="term" value="P:vesicle tethering to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MENTAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051869">
        <property type="entry name" value="STARD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121:SF1">
        <property type="entry name" value="STARD3 N-TERMINAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46121">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10457">
        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MENTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="MENTAL" evidence="7">
        <location>
            <begin position="31"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010909"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51439"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024234.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="214" mass="24212" checksum="76B5633E8FEB9B11" modified="2022-01-19" version="1">MNHLPEDMQDVLTGSQSSHASVRSVHSINPTQLMARIESYEGREKKGTYDVRRTLFLNVNGGIENTLEREVVQYDYYSSYFDKFLLAVFRFKVLILTYAVCILRHWWAIVLTTAVTSAFLLAKVILSKLFSQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEENRLLIVQDVSESAALLPGGLSDGQFYSPPESEAGSEEAEEKTVKSTKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VPI8</accession>
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        <submittedName>
            <fullName evidence="4">Chromosome 1 open reading frame 127</fullName>
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        <submittedName>
            <fullName evidence="4">Ciliated left-right organizer protein containing ZP-N domains</fullName>
        </submittedName>
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        <name evidence="4" type="primary">C1orf127</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
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            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002396">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002397">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002398">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VPI8"/>
    <dbReference type="Ensembl" id="ENSMICT00000033432.2">
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        <property type="gene ID" value="ENSMICG00000028837.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003592"/>
    <dbReference type="Proteomes" id="UP000694394">
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    </dbReference>
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        <property type="entry name" value="CIROZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049521">
        <property type="entry name" value="CIROZ_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38653">
        <property type="entry name" value="GENE 572-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38653:SF1">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034036513" evidence="2">
        <location>
            <begin position="22"/>
            <end position="803"/>
        </location>
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        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15094"/>
        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="803" mass="84310" checksum="225ECE7D4A6EFBD3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQ27</accession>
    <name>A0A8C5VQ27_MICMU</name>
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        <submittedName>
            <fullName evidence="4">Basonuclin zinc finger protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">BNC1</name>
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        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
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                <person name="Jayaseelan J."/>
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                <person name="Kurapati P."/>
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                <person name="Lee S."/>
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                <person name="Narasimhan A."/>
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                <person name="Nguyen L."/>
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                <person name="Shamim M."/>
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                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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            </authorList>
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    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5. Interacts with UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03004957">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VTX0"/>
    <dbReference type="Ensembl" id="ENSMICT00000041397.2">
        <property type="protein sequence ID" value="ENSMICP00000030212.1"/>
        <property type="gene ID" value="ENSMICG00000030891.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154351"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07854">
        <property type="entry name" value="STKc_MAPK4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000136">
        <property type="entry name" value="mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000223">
        <property type="entry name" value="Mitogen-activated protein kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008350">
        <property type="entry name" value="MAPK_ERK3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01771">
        <property type="entry name" value="ERK3ERK4MAPK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00054417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="722" mass="82794" checksum="CA012AF3C10FAC6E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VV27</accession>
    <name>A0A8C5VV27_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rho guanine nucleotide exchange factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ARHGEF11</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003175">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000043857.2">
        <property type="protein sequence ID" value="ENSMICP00000030954.2"/>
        <property type="gene ID" value="ENSMICG00000009042.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158350"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007266">
        <property type="term" value="P:Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23069">
        <property type="entry name" value="PDZ_ARHGEF11-12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13391">
        <property type="entry name" value="PH_PRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08753">
        <property type="entry name" value="RGS_PDZRhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.167.10:FF:000010">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000006">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000033">
        <property type="entry name" value="Rho guanine nucleotide exchange factor (GEF) 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000072">
        <property type="entry name" value="Rho guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VVF7</accession>
    <name>A0A8C5VVF7_MICMU</name>
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            <fullName evidence="10">Dehydrogenase/reductase SDR family member 11</fullName>
            <ecNumber evidence="3">1.1.1.270</ecNumber>
            <ecNumber evidence="4">1.1.1.62</ecNumber>
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            <fullName evidence="11">17-beta-hydroxysteroid dehydrogenase</fullName>
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        <alternativeName>
            <fullName evidence="12">3-beta-hydroxysteroid 3-dehydrogenase</fullName>
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        <alternativeName>
            <fullName evidence="14">Estradiol 17-beta-dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Short-chain dehydrogenase/reductase family 24C member 1</fullName>
        </alternativeName>
    </protein>
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        <name evidence="16" type="primary">DHRS11</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones.</text>
    </comment>
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        <reaction evidence="6">
            <text>17beta-estradiol + NAD(+) = estrone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>17beta-estradiol + NADP(+) = estrone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24616"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.62"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36836"/>
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            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.270"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Steroid biosynthesis; estrogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 16"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Mgc4172-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADP-dependent L-serine/L-allo-threonine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 11"/>
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        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00052853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="260" mass="28237" checksum="BAEC369949705656" modified="2022-01-19" version="1">MARAGMERWRDRVALVTGASGGIGASVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYKCDLANEEEILSMFSAIRSQHSGVDICINNAGFARPDSLLSGSTSGWKAMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVVPVSAIHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEHMKCLKPEDVAETVIYVLSTPPHVQIGDIQMRPTEQVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VVN3</accession>
    <name>A0A8C5VVN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA-binding protein inhibitor ID-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Inhibitor of DNA binding 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Inhibitor of differentiation 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ID3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606238.1">
        <property type="nucleotide sequence ID" value="XM_012750784.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VVN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000034748.2">
        <property type="protein sequence ID" value="ENSMICP00000031108.1"/>
        <property type="gene ID" value="ENSMICG00000030561.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000064913.1">
        <property type="protein sequence ID" value="ENSMICP00000047080.1"/>
        <property type="gene ID" value="ENSMICG00000030561.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863546"/>
    <dbReference type="KEGG" id="mmur:105863546"/>
    <dbReference type="CTD" id="3399"/>
    <dbReference type="GeneTree" id="ENSGT00940000160504"/>
    <dbReference type="OrthoDB" id="10047910at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901707">
        <property type="term" value="F:leptomycin B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140416">
        <property type="term" value="F:transcription regulator inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072750">
        <property type="term" value="P:cellular response to leptomycin B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001656">
        <property type="term" value="P:metanephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045662">
        <property type="term" value="P:negative regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030903">
        <property type="term" value="P:notochord development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042476">
        <property type="term" value="P:odontogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19693">
        <property type="entry name" value="bHLH_dnHLH_ID3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000039">
        <property type="entry name" value="DNA-binding protein inhibitor ID-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026052">
        <property type="entry name" value="DNA-bd_prot-inh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11723:SF16">
        <property type="entry name" value="DNA-BINDING PROTEIN INHIBITOR ID-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="12">
        <location>
            <begin position="28"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="119" mass="12953" checksum="69198B56B4DCFFBD" modified="2022-01-19" version="1">MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELAPELVIANDKRSFCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWF3</accession>
    <name>A0A8C5VWF3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneTree" id="ENSGT00940000154800"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
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    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
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    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Yippee" evidence="1">
        <location>
            <begin position="13"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="119" mass="12929" checksum="79FA836AC147ECE5" modified="2022-01-19" version="1">MGRIFLDHIGGTGLFSCANCDTIPTNRLELISTPFTGATGRAFLFNKVVNLQCSEVQDRVMLTGRHVVRDVSCKNCNSKLGCGSMSLPLKAASKGRVILERALVRESEGFEEHVPSDNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W177</accession>
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        <recommendedName>
            <fullName evidence="14">Signal transducer and activator of transcription</fullName>
        </recommendedName>
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        <name evidence="16" type="primary">STAT5B</name>
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    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the transcription factor STAT family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020168">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598668.1">
        <property type="nucleotide sequence ID" value="XM_012743214.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5W177"/>
    <dbReference type="Ensembl" id="ENSMICT00000053254.2">
        <property type="protein sequence ID" value="ENSMICP00000034839.2"/>
        <property type="gene ID" value="ENSMICG00000011988.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065113.1">
        <property type="protein sequence ID" value="ENSMICP00000047605.1"/>
        <property type="gene ID" value="ENSMICG00000011988.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065363.1">
        <property type="protein sequence ID" value="ENSMICP00000044742.1"/>
        <property type="gene ID" value="ENSMICG00000011988.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859420"/>
    <dbReference type="KEGG" id="mmur:105859420"/>
    <dbReference type="CTD" id="6777"/>
    <dbReference type="GeneTree" id="ENSGT01080000257420"/>
    <dbReference type="OrthoDB" id="19300at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903706">
        <property type="term" value="P:regulation of hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10420">
        <property type="entry name" value="SH2_STAT5b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16855">
        <property type="entry name" value="STAT5_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16849">
        <property type="entry name" value="STAT5_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.532.10:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.630:FF:000002">
        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and activator of transcription"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Signal transducer and transcription activator 6"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.20">
        <property type="entry name" value="STAT transcription factor, all-alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.630">
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    </dbReference>
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        <property type="entry name" value="STAT transcription factor, N-terminal domain"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
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        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001217">
        <property type="entry name" value="STAT"/>
    </dbReference>
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        <property type="entry name" value="STAT5_CC"/>
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    <dbReference type="InterPro" id="IPR035858">
        <property type="entry name" value="STAT5a/5b_DBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035886">
        <property type="entry name" value="STAT5b_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048988">
        <property type="entry name" value="STAT_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036535">
        <property type="entry name" value="STAT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013800">
        <property type="entry name" value="STAT_TF_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015988">
        <property type="entry name" value="STAT_TF_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013801">
        <property type="entry name" value="STAT_TF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012345">
        <property type="entry name" value="STAT_TF_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013799">
        <property type="entry name" value="STAT_TF_prot_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11801">
        <property type="entry name" value="SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01017">
        <property type="entry name" value="STAT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02864">
        <property type="entry name" value="STAT_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02865">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21354">
        <property type="entry name" value="STAT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00964">
        <property type="entry name" value="STAT_int"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48092">
        <property type="entry name" value="Transcription factor STAT-4 N-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0010">Activator</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 14" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 14" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SH2" evidence="15">
        <location>
            <begin position="589"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU046415"/>
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    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034839.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="786" mass="90042" checksum="E8E9D72680165AF0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W285</accession>
    <name>A0A8C5W285_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Alkylglycerol monooxygenase</fullName>
            <ecNumber evidence="12">1.14.16.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transmembrane protein 195</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">AGMO</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>1-O-(1,2-saturated-alkyl)-sn-glycerol + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 = a 1-(1-hydroxyalkyl)-sn-glycerol + (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:36255"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="ChEBI" id="CHEBI:59560"/>
            <dbReference type="ChEBI" id="CHEBI:73418"/>
            <dbReference type="ChEBI" id="CHEBI:83957"/>
            <dbReference type="EC" id="1.14.16.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the sterol desaturase family. TMEM195 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.16.5" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03015536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597416.1">
        <property type="nucleotide sequence ID" value="XM_012741962.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W285"/>
    <dbReference type="Ensembl" id="ENSMICT00000026494.2">
        <property type="protein sequence ID" value="ENSMICP00000031820.2"/>
        <property type="gene ID" value="ENSMICG00000033056.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858663"/>
    <dbReference type="CTD" id="392636"/>
    <dbReference type="GeneTree" id="ENSGT00440000033807"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050479">
        <property type="term" value="F:glyceryl-ether monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046485">
        <property type="term" value="P:ether lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006643">
        <property type="term" value="P:membrane lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056853">
        <property type="entry name" value="AGMP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051689">
        <property type="entry name" value="Sterol_desaturase/TMEM195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624:SF1">
        <property type="entry name" value="ALKYLGLYCEROL MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21624">
        <property type="entry name" value="STEROL DESATURASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24858">
        <property type="entry name" value="AGMP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="17">
        <location>
            <begin position="118"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Alkylglycerol monooxygenase C-terminal" evidence="18">
        <location>
            <begin position="335"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00040992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031820.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="445" mass="51789" checksum="4A6FA0B7D90561EC" modified="2022-01-19" version="1">MKNPEAQQDVSVSQGVRMMFYMMKPNETSFQTLEEVPDYVQKATPFFISLMLLELVVSWICKGKPPGRLDDALTSISAGVLSRLPSLFFRSIELTTYIYIWENYRLFNLPWDSPWTWYLTFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDYNLSTALRQSVLQIYTSWIFYTPLALFIPPSVYAVHLQFNLLYQFWIHTEVITNLGFLELILNTPSHHRVHHGRNRYCIDKNYAAVLIIWDRIFGTFEAENEKVVYGLTHPINTFEPIKVQFHHLFYIWSTFWATPGFFHKFSVIFKGPGWGPGKPRLGLSEEIPQVTGKEVPFSSSASQLLKIYTVVQFALMLAFYEETFANTAALSQVTLLLRICFIILTLTSIGFLLDQRPKAAFMETLRCLVFLMLYRFGHLKPLVPSLSFAFEVFFSICIAFWGVRSMKQLISGPWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W5Q2</accession>
    <name>A0A8C5W5Q2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="59">Patatin-like phospholipase domain-containing protein 2</fullName>
            <ecNumber evidence="7">3.1.1.3</ecNumber>
            <ecNumber evidence="6">3.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="61">Adipose triglyceride lipase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="60">Calcium-independent phospholipase A2-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="65" type="primary">PNPLA2</name>
    </gene>
    <organism evidence="65 66">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="65" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="65" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="65" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>1,2,3-tri-(10Z)-heptadecenoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(10Z-heptadecenoyl)-sn-glycerol + 9-(10Z-heptadecenoyloxy)-octadecanoate</text>
            <dbReference type="Rhea" id="RHEA:75019"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:194143"/>
            <dbReference type="ChEBI" id="CHEBI:194145"/>
            <dbReference type="ChEBI" id="CHEBI:228204"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1,2,3-tri-(9Z)-hexadecenoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + 9-(9Z-hexadecenoyloxy)-octadecanoate</text>
            <dbReference type="Rhea" id="RHEA:75027"/>
            <dbReference type="ChEBI" id="CHEBI:75841"/>
            <dbReference type="ChEBI" id="CHEBI:75853"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:136309"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="42">
            <text>1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = 1,3-di-(9Z)-hexadecenoylglycerol + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:75841"/>
            <dbReference type="ChEBI" id="CHEBI:75849"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="42">
            <dbReference type="Rhea" id="RHEA:38396"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="56">
            <text>1,2,3-tri-(9Z)-hexadecenoylglycerol + H2O = 2,3-di-(9Z)-hexadecenoyl-sn-glycerol + (9Z)-hexadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32372"/>
            <dbReference type="ChEBI" id="CHEBI:75841"/>
            <dbReference type="ChEBI" id="CHEBI:75853"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="56">
            <dbReference type="Rhea" id="RHEA:38400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="48">
            <text>1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + 9-hydroxy-octadecanoate = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + 9-(9Z,12Z-octadecadienoyloxy)-octadecanoate</text>
            <dbReference type="Rhea" id="RHEA:75023"/>
            <dbReference type="ChEBI" id="CHEBI:75844"/>
            <dbReference type="ChEBI" id="CHEBI:75854"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
            <dbReference type="ChEBI" id="CHEBI:194142"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="49">
            <text>1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 1,3-di-(9Z,12Z)-octadecadienoylglycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38403"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75844"/>
            <dbReference type="ChEBI" id="CHEBI:75850"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="49">
            <dbReference type="Rhea" id="RHEA:38404"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="45">
            <text>1,2,3-tri-(9Z,12Z)-octadecadienoylglycerol + H2O = 2,3-di-(9Z,12Z)-octadecadienoyl-sn-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:75844"/>
            <dbReference type="ChEBI" id="CHEBI:75854"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="45">
            <dbReference type="Rhea" id="RHEA:38408"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = 1,3-di-(9Z,12Z,15Z)-octadecatrienoylglycerol + (9Z,12Z,15Z)-octadecatrienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38411"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32387"/>
            <dbReference type="ChEBI" id="CHEBI:75845"/>
            <dbReference type="ChEBI" id="CHEBI:75852"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:38412"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="54">
            <text>1,2,3-tri-(9Z,12Z,15Z)-octadecatrienoylglycerol + H2O = 2,3-di-(9Z,12Z,15Z)-octadecatrienoyl-sn-glycerol + (9Z,12Z,15Z)-octadecatrienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38415"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32387"/>
            <dbReference type="ChEBI" id="CHEBI:75845"/>
            <dbReference type="ChEBI" id="CHEBI:75855"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="54">
            <dbReference type="Rhea" id="RHEA:38416"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="41">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + 9-hydroxy-octadecanoate = 9-(9Z-octadecenoyloxy)-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:75011"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:38388"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:38392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1,2,3-tri-(9Z-octadecenoyl)-glycerol + all-trans-retinol = all-trans-retinyl 9Z-octadecenoate + di-(9Z)-octadecenoylglycerol</text>
            <dbReference type="Rhea" id="RHEA:39987"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:70760"/>
            <dbReference type="ChEBI" id="CHEBI:75945"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:39988"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="44">
            <text>1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 1-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38423"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75583"/>
            <dbReference type="ChEBI" id="CHEBI:75867"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="44">
            <dbReference type="Rhea" id="RHEA:38424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1,2-di-(9Z)-octadecenoyl-3-hexadecanoyl-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-3-hexadecanoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75546"/>
            <dbReference type="ChEBI" id="CHEBI:75583"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:38644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,2-di-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H(+) = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O</text>
            <dbReference type="Rhea" id="RHEA:38379"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:38381"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="47">
            <text>1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 1,3-di-(9Z-octadecenoyl)-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38419"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
            <dbReference type="ChEBI" id="CHEBI:75846"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="47">
            <dbReference type="Rhea" id="RHEA:38420"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1,3-di-(9Z)-octadecenoyl-2-hexadecanoylglycerol + H2O = 2-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38431"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75846"/>
            <dbReference type="ChEBI" id="CHEBI:75870"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:38432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="52">
            <text>1-(9Z-octadecenoyl)-glycerol + 1,2-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol</text>
            <dbReference type="Rhea" id="RHEA:38327"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="52">
            <dbReference type="Rhea" id="RHEA:38328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-(9Z-octadecenoyl)-glycerol + 1,3-di-(9Z-octadecenoyl)-glycerol = 1,2,3-tri-(9Z-octadecenoyl)-glycerol + glycerol</text>
            <dbReference type="Rhea" id="RHEA:38331"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:53753"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
            <dbReference type="ChEBI" id="CHEBI:75735"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:38332"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="43">
            <text>1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + 9-(9Z-octadecenoyloxy)-octadecanoate</text>
            <dbReference type="Rhea" id="RHEA:75035"/>
            <dbReference type="ChEBI" id="CHEBI:75847"/>
            <dbReference type="ChEBI" id="CHEBI:75868"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="55">
            <text>1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + 9-hydroxy-octadecanoate = 9-hexadecanoyloxy-octadecanoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:75015"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75847"/>
            <dbReference type="ChEBI" id="CHEBI:83670"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 1-hexadecanoyl-3-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38647"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:75847"/>
            <dbReference type="ChEBI" id="CHEBI:75868"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:38648"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1-hexadecanoyl-2,3-di-(9Z)-octadecenoyl-sn-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38427"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75824"/>
            <dbReference type="ChEBI" id="CHEBI:75847"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:38428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>2 1-(9Z-octadecenoyl)-glycerol = 1,2-di-(9Z-octadecenoyl)-glycerol + glycerol</text>
            <dbReference type="Rhea" id="RHEA:38323"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:52323"/>
            <dbReference type="ChEBI" id="CHEBI:75342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:38324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>2 a 1-acylglycerol = a 1,2-diacylglycerol + glycerol</text>
            <dbReference type="Rhea" id="RHEA:44432"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:35759"/>
            <dbReference type="ChEBI" id="CHEBI:49172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:44433"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="46">
            <text>9-hydroxy-octadecanoate + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 9-(9Z-octadecenoyloxy)-octadecanoate + 2-(9Z-octadecenoyl)-glycerol</text>
            <dbReference type="Rhea" id="RHEA:75031"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:73990"/>
            <dbReference type="ChEBI" id="CHEBI:136282"/>
            <dbReference type="ChEBI" id="CHEBI:136286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="53">
            <text>a 1-acylglycerol + a 1,2-diacylglycerol = a triacylglycerol + glycerol</text>
            <dbReference type="Rhea" id="RHEA:44436"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:35759"/>
            <dbReference type="ChEBI" id="CHEBI:49172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="53">
            <dbReference type="Rhea" id="RHEA:44437"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="51">
            <text>a 1-acylglycerol + a 1,3-diacylglycerol = a triacylglycerol + glycerol</text>
            <dbReference type="Rhea" id="RHEA:44440"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:35759"/>
            <dbReference type="ChEBI" id="CHEBI:47777"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="51">
            <dbReference type="Rhea" id="RHEA:44441"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="57">
            <text>a triacyl-sn-glycerol + H2O = a 1,3-diacyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43732"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="ChEBI" id="CHEBI:77272"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="57">
            <dbReference type="Rhea" id="RHEA:43733"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="50">
            <text>a triacyl-sn-glycerol + H2O = a 2,3-diacyl-sn-glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38499"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="ChEBI" id="CHEBI:75524"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="50">
            <dbReference type="Rhea" id="RHEA:38500"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>a triacylglycerol + H2O = a 1,2-diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:49172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:35668"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>a triacylglycerol + H2O = a 1,3-diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38495"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:47777"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:38496"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:12045"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol</text>
            <dbReference type="Rhea" id="RHEA:44676"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:63410"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:44677"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycerolipid metabolism; triacylglycerol degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="58">Interacts with ABHD5; this association stimulates PNPLA2 triglyceride hydrolase activity. Interacts with SERPINF1; this interaction stimulates the phospholipase A2 activity of PNPLA2. Despite a colocalization in lipid droplets, it probably does not interact with PLIN. Interacts with PLIN5; prevents interaction with ABHD5. Interacts with FAF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lipid droplet</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="7"/>
    <dbReference type="EC" id="3.1.1.4" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03005960">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5Q2"/>
    <dbReference type="Ensembl" id="ENSMICT00000041207.2">
        <property type="protein sequence ID" value="ENSMICP00000034362.2"/>
        <property type="gene ID" value="ENSMICG00000034349.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160155"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <keyword evidence="14 62" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
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    <keyword evidence="12" id="KW-0551">Lipid droplet</keyword>
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    <keyword evidence="20" id="KW-0472">Membrane</keyword>
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    <keyword evidence="66" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="PNPLA" evidence="64">
        <location>
            <begin position="10"/>
            <end position="179"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
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            <begin position="14"/>
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    </feature>
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            <begin position="45"/>
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        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <position position="47"/>
        </location>
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    <feature type="active site" description="Proton acceptor" evidence="62">
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            <position position="166"/>
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    <sequence length="485" mass="53242" checksum="0B7791CD8D359C2E" modified="2022-01-19" version="1">MFPRETTWNISFAGCGFLGVYHIGVASCLREHAPFLVANATHIYGASAGALTATALVTGACLGESGANIIEVSKEARKRFLGPLHPSFNLVKTIRGCLLKTLPADSHERANGRLGISLTRVSDGENVIISHFNSKEELIQANVCSTFIPVYCGLIPPSLQGVRYVDGGISDNLPLYELKNTITVSPFSGESDICPQDSSTNIHELRVTNTSIQFNLRNLYRLSKALFPPEPMVLREMCKQGYRDGLRFLRRNGLLNQPNPLLALPPAHPGAPEEEAEEEAAERAQVEDPLQPPREDHILEHLPARLNEALLEACVEPKDLMTTLSNMLPVRLATAMMVPYTLPLESAVSFTIRCALLEWLPDVPEDIRWVKEQTGSICQYLVMRAKRNLRSRLSARLSGQVELRRAQSLPSVPLSCAAYSEVLPSWMRNNLSLGDALAKWEECQRQLLLGLFCTNMAFPPDALRMRAPAGPAPADPAPGPGLPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XAU1</accession>
    <name>A0A8C5XAU1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Chromodomain helicase DNA binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CHD2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000000332.3">
        <property type="protein sequence ID" value="ENSMICP00000000303.3"/>
        <property type="gene ID" value="ENSMICG00000000332.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155888"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18666">
        <property type="entry name" value="CD1_tandem_CHD1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18661">
        <property type="entry name" value="CD2_tandem_CHD1-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18054">
        <property type="entry name" value="DEXHc_CHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000106">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000008">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000014">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000007">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000130">
        <property type="entry name" value="Chromodomain-helicase-DNA-binding protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040793">
        <property type="entry name" value="CDH1_2_SANT_HL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF19">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18375">
        <property type="entry name" value="CDH1_2_SANT_HL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13907">
        <property type="entry name" value="CHD1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="254"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="371"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="489"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="788"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1021"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1322"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1546"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1669"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="19"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1338"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1387"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1556"/>
            <end position="1565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1575"/>
            <end position="1592"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1687"/>
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            <begin position="1728"/>
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            <begin position="1749"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
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            <end position="1803"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00049360"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50013"/>
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            <dbReference type="PROSITE" id="PS51192"/>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000303.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1817" mass="210258" checksum="89118F7D55D00ED9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XL55</accession>
    <name>A0A8C5XL55_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thymocyte selection associated high mobility group box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TOX</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03012640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_020288798.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000033570.2"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002362">
        <property type="term" value="P:CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043375">
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    <dbReference type="GO" id="GO:0021895">
        <property type="term" value="P:cerebral cortex neuron differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048535">
        <property type="term" value="P:lymph node development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:NK T cell lineage commitment"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:Peyer's patch development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of natural killer cell differentiation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of neural precursor cell proliferation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1902232">
        <property type="term" value="P:regulation of positive thymic T cell selection"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="HMG-box_TOX-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TOX high mobility group box family member 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HMG_box_dom"/>
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        <property type="entry name" value="HMG_box_dom_sf"/>
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        <property type="entry name" value="TOX_HMG-box_domain"/>
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        <property type="entry name" value="AGAP000281-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45781:SF4">
        <property type="entry name" value="THYMOCYTE SELECTION-ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN TOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="261"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="261"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="178"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="264"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="245"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033570.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="526" mass="57551" checksum="33AC40E26A83360E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XLN1</accession>
    <name>A0A8C5XLN1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase NEURL3</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Lung-inducible neuralized-related C3CH4 RING domain protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Neuralized-like protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">RING-type E3 ubiquitin transferase NEURL3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">NEURL3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03005347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XLN1"/>
    <dbReference type="Ensembl" id="ENSMICT00000012519.3">
        <property type="protein sequence ID" value="ENSMICP00000034993.2"/>
        <property type="gene ID" value="ENSMICG00000012532.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162540"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901800">
        <property type="term" value="P:positive regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16552">
        <property type="entry name" value="RING-HC_NEURL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000050">
        <property type="entry name" value="Neuralized E3 ubiquitin protein ligase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000527">
        <property type="entry name" value="Neuralized E3 ubiquitin protein ligase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037962">
        <property type="entry name" value="Neuralized"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006573">
        <property type="entry name" value="NHR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEURL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12429">
        <property type="entry name" value="NEURALIZED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07177">
        <property type="entry name" value="Neuralized"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00588">
        <property type="entry name" value="NEUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51065">
        <property type="entry name" value="NHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="NHR" evidence="19">
        <location>
            <begin position="17"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="202"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034993.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="262" mass="28513" checksum="A0011E41CC53D227" modified="2022-01-19" version="1">MGAQLSFEANAKSPGEALRFHTEAKGAQVHLDTRGCTAHRRATFHDGIVFSQRPVLPGERVALRVLRQEGGWRGGLRVGFTRLDPARVSASSLPPFVCPDLEERSPTWAAMLPDRCVLEGNVVRFWVNQRGWLFAKINAGRPILLRKGVLMGAPLWAVMDVYGTTKAIELLDPTASLYPTTSWSVLSDEAVAEPEATSGEECAICFYHAANTCLVPCGHTHFCSSCSWRVFRDTAKCPVCRWQIEAVVPAVPPPLGTGVGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XN20</accession>
    <name>A0A8C5XN20_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Programmed cell death 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PDCD1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03010567">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010568">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XN20"/>
    <dbReference type="Ensembl" id="ENSMICT00000033401.2">
        <property type="protein sequence ID" value="ENSMICP00000038072.1"/>
        <property type="gene ID" value="ENSMICG00000032951.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013662"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050868">
        <property type="term" value="P:negative regulation of T cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002841">
        <property type="term" value="P:negative regulation of T cell mediated immune response to tumor cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070234">
        <property type="term" value="P:positive regulation of T cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16088">
        <property type="entry name" value="IgV_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042379">
        <property type="entry name" value="PDCD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15264">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15264:SF2">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034919599" evidence="3">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="4">
        <location>
            <begin position="28"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="292" mass="31853" checksum="53EF69D54941411B" modified="2022-01-19" version="1">MRTPQGPWAVLWAVLQLGWRPGWLLDAPDRPLSFSPARLTVPEGANATFTCSFSNTSEIFVLNWYRMSPSNQTDKLAAFPRDRSQPGQDPRFHVTQLPDGRGFHMSVVAARRNDSGTYLCGAIFLKPKTQIKESPRAELTVTERVEESSTPHPSPLPTPGGQFQSLVVSITSVLVCVLVLLLLAWVLTAVCPRATRGAGGARNTDQLPEGALKKEDPSAMPAFTVDYGVLDFQCREKTPEPPAPCVPEQTEYATIVFPNGLGVSSPGRRVSADSPQGPRPLRPEDGHCSWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XRF2</accession>
    <name>A0A8C5XRF2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nudix hydrolase 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NUDT8</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ABDC03006024">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XRF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000036534.2">
        <property type="protein sequence ID" value="ENSMICP00000039928.1"/>
        <property type="gene ID" value="ENSMICG00000031375.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162775"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046356">
        <property type="term" value="P:acetyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044580">
        <property type="term" value="P:butyryl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001294">
        <property type="term" value="P:malonyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036114">
        <property type="term" value="P:medium-chain fatty-acyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902859">
        <property type="term" value="P:propionyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901289">
        <property type="term" value="P:succinyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF11">
        <property type="entry name" value="MITOCHONDRIAL COENZYME A DIPHOSPHATASE NUDT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="214" mass="23641" checksum="538395D86084642A" modified="2022-01-19" version="1">MLPDFLSAEAERRCRRLLAEATARLRARPASAAVLVPLCSVRGVPALLYTLRSRRLAGSHTGEVSFPGGKCEAADRDVVHTALRETQEELGLAVPEEQVWGTLRPVYDRQKATVVPVLAGVGPLDLRSLRPNPEEVDEVFVLPMAHLLQTQNQGYTHFCRGGHFSYTLPVFLHGPHRVWGLTAVITELTLQLLAPGSYQPRLSIPELRRASLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XSE6</accession>
    <name>A0A8C5XSE6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spermatosis associated 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPATA9</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03016877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000070039.1">
        <property type="protein sequence ID" value="ENSMICP00000040790.1"/>
        <property type="gene ID" value="ENSMICG00000044517.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014160"/>
    <dbReference type="OMA" id="LSEPMFP"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031659">
        <property type="entry name" value="SPATA9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35669">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35669:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15824">
        <property type="entry name" value="SPATA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="255" mass="28888" checksum="C3D59632D29E0FE0" modified="2022-01-19" version="1">MPIKPVGWICGQVLKNFSGRIEGIQKVIMDLVDEFKDDFPTILRLSQSKQKKGPAQKTSKVKMAIALAKINRGTLIRGLSSISRSSKSVAKLLQPQLTCRLLELRDISRRLLREVNAPRQPLYNIQVRKGSLFEIISFPAKTALTSIIYASYAALIYLAVCVNAVLEKVKNIFQEEESIRQNRQENENFRNAFSEPVLSEPLFPDSEIKAKSYRSLPEKPDKIADRTKLPSNKQSNKIQVLHSVFDQSAEMNEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTP7</accession>
    <name>A0A8C5XTP7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03033374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTP7"/>
    <dbReference type="Ensembl" id="ENSMICT00000065588.1">
        <property type="protein sequence ID" value="ENSMICP00000041296.1"/>
        <property type="gene ID" value="ENSMICG00000047063.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011514"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027904">
        <property type="entry name" value="DUF4587"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038915">
        <property type="entry name" value="PRR29-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28604">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28604:SF2">
        <property type="entry name" value="RIKEN CDNA 2610028H24 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15248">
        <property type="entry name" value="DUF4587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4587" evidence="2">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="268" mass="29082" checksum="B84E2AF14411EDEC" modified="2022-01-19" version="1">ATPSQPGPRVPWRLDPVALGPPGPRGSRKGWFPGGKLRPRQAAGGGCGSPAPTGCDMLDSSVAEQMTRLTLRLLGQKLEQERENVDGDSEGPHLLPGESCGVGGTGMRRVLRPLQEQHLLDELAQAHSWRELHGGARGPALPPEVPHAYPVVTSPPPLAPEPPRIIQHPVPQPPATIIHQLPQQPLIAQIPPPQAFPTPRSGTFKEDMVDLLLLQSAQAHQILTHSLLLQALPRPAPQWAPPAVPQAARPRPPAHRLRHRHRHQHRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTY0</accession>
    <name>A0A8C5XTY0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ras-related protein Rab-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RAB4B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Cell membrane</location>
            <topology evidence="17">Lipid-anchor</topology>
            <orientation evidence="17">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTY0"/>
    <dbReference type="Ensembl" id="ENSMICT00000069672.1">
        <property type="protein sequence ID" value="ENSMICP00000041119.1"/>
        <property type="gene ID" value="ENSMICG00000045158.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159399"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032593">
        <property type="term" value="C:insulin-responsive compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034498">
        <property type="term" value="P:early endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04113">
        <property type="entry name" value="Rab4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000280">
        <property type="entry name" value="Putative ras-related protein Rab-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041819">
        <property type="entry name" value="Rab4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="12 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 17" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="221" mass="24442" checksum="B19EE0A2A17C460C" modified="2022-01-19" version="1">ALSGRDRVMAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDSGELDPERMGSGIQYGDASLRQLRQPRSAQAVAPQPCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXK4</accession>
    <name>A0A8C5XXK4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Placenta associated 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PLAC8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012622194.2">
        <property type="nucleotide sequence ID" value="XM_012766740.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000069504.1">
        <property type="protein sequence ID" value="ENSMICP00000042807.1"/>
        <property type="gene ID" value="ENSMICG00000046029.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105872596"/>
    <dbReference type="GeneTree" id="ENSGT00940000157329"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050873">
        <property type="term" value="P:brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040015">
        <property type="term" value="P:negative regulation of multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="110" mass="11969" checksum="9A7381DF706920C4" modified="2022-01-19" version="1">MQAQPPVVVVTQPTYGPAPQNSNWQTGMCDCFNDCGVCLCASFCFVCLGCQVASDMNECCLCGTSVAMRTLYRTRYGIPVSLLRSCSVPTCNPLQDDDPKRGDRWLASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXY7</accession>
    <name>A0A8C5XXY7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">R3H domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018326">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018327">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXY7"/>
    <dbReference type="Ensembl" id="ENSMICT00000065987.1">
        <property type="protein sequence ID" value="ENSMICP00000043191.1"/>
        <property type="gene ID" value="ENSMICG00000042655.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156095"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000001">
        <property type="entry name" value="R3H domain-containing protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF12">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="124"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="188"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043191.1"/>
        </source>
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    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="102372" checksum="6A36642283845088" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYT9</accession>
    <name>A0A8C5XYT9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitochondrial ribosomal protein S36</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019232">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYT9"/>
    <dbReference type="Ensembl" id="ENSMICT00000061630.1">
        <property type="protein sequence ID" value="ENSMICP00000043101.1"/>
        <property type="gene ID" value="ENSMICG00000047062.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017443"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:2-oxoglutarate metabolic process"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11424" checksum="DC52548CDF747B5B" modified="2022-01-19" version="1">LHGSKMASASRVVQVVKPHTPLIRFPDRRDNPKLNVSEALRSAGLPSHSSAISQHSKGSKSPDLLMYQGPPDTAEIIKTLPQKYRRKLVSQEEIEFIQRGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZA5</accession>
    <name>A0A8C5XZA5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PRAME nuclear receptor transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PRAME</name>
        <name evidence="4" type="synonym">LOC105869622</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024690">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZA5"/>
    <dbReference type="Ensembl" id="ENSMICT00000065988.1">
        <property type="protein sequence ID" value="ENSMICP00000043834.1"/>
        <property type="gene ID" value="ENSMICG00000047428.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234531"/>
    <dbReference type="OMA" id="CPCFMPA"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042974">
        <property type="term" value="F:nuclear retinoic acid receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048387">
        <property type="term" value="P:negative regulation of retinoic acid receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000354">
        <property type="entry name" value="Melanoma antigen preferentially expressed in tumors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026271">
        <property type="entry name" value="PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF24">
        <property type="entry name" value="MELANOMA ANTIGEN PREFERENTIALLY EXPRESSED IN TUMORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038286">
        <property type="entry name" value="PRAME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="509" mass="57004" checksum="4E4ABB72D7AE4669" modified="2022-01-19" version="1">VDGRRRQDSFRSIFIRMSVWMSPPSLLELAGQSLLRDEALAIAALEELPGELFPPLFAVAFFGRRGETLKAMVQAWPFACLPLGALMKEQRPTPEIFQAALDGLDGLLAQEVRPRRWKLHVLDLRKNAHQDFWTVWSGTRLGVCSWLEPAAAQPVRKKQKVNASSSVAAEQPLAPVEVVIDLSLKQGTQDALLTYLIEKVKQKKGLLHLCCKKLKIFAMPMQNIKMILSMVQLDSIEDLEVNCTWKLSTLGKFSPLLGRMSNLQRLLLSHIHMSSTSPEKEEQCVAQFTSQFHCLLHLQELYLDSISFLKGRLDQVLRCLKSPLETLSITNCQLSESDLTCLSQCPSISQLKDLGLSGVILTDISPEPLQVLLERTSATLQDLDLDECGIMDSQFVVILPALGRCSQLTTFSFCGNPISMAVLERLLHHTIGLSRLSHVLYPAPLESYEDTRGTLHLGRLAYLHAKLKRMLQESGRPGMVWFSANPCPRCGDRTFYDPEPILCPCFMPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y294</accession>
    <name>A0A8C5Y294_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein WDR12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">WD repeat-containing protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">WDR12</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010868">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594408.1">
        <property type="nucleotide sequence ID" value="XM_012738954.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594409.1">
        <property type="nucleotide sequence ID" value="XM_012738955.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y294"/>
    <dbReference type="Ensembl" id="ENSMICT00000064193.1">
        <property type="protein sequence ID" value="ENSMICP00000044766.1"/>
        <property type="gene ID" value="ENSMICG00000044580.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105856935"/>
    <dbReference type="KEGG" id="mmur:105856935"/>
    <dbReference type="CTD" id="55759"/>
    <dbReference type="GeneTree" id="ENSGT00930000150950"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000272">
        <property type="entry name" value="Ribosome biogenesis protein WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="9">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="136"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="338"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="423" mass="47840" checksum="740BC1016FB5C925" modified="2022-01-19" version="1">MAQLQTRFYTDNKKYAVDDVPFSIPAASEIADLSNIINKLLKDKNEFHKHVEFDFLIKGQFLRMPLVKHMELENISSEEVVELEYVEKYTAPQSEQCMFHDDWISSIKGTEEWILTGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLSASMDQTILLWEWNVERNKVKALHCCRGHAGSVDSIAVDSSGTKFCSGSWDKMLKIWSTVPTDEEDEMEESTSRPRKKQKTEQLGLTRTPMVTLSGHKEAISSVLWSDPEEICSASWDHTIRVWDVESGSLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLVLLSLTSHTGWVTSVKWSPTHEQQLISGSLDNMVKLWDTRSCKAPLYDLDAHEDKVLSVDWTDTGLLLSGGADNKLYSYRYSPTTSHVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y386</accession>
    <name>A0A8C5Y386_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 273</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019206">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y386"/>
    <dbReference type="Ensembl" id="ENSMICT00000067239.1">
        <property type="protein sequence ID" value="ENSMICP00000045533.1"/>
        <property type="gene ID" value="ENSMICG00000045683.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000409"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029395">
        <property type="entry name" value="DUF4514"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37857">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37857:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14986">
        <property type="entry name" value="DUF4514"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034466863" evidence="2">
        <location>
            <begin position="21"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="106" mass="11262" checksum="557708A720B5388E" modified="2022-01-19" version="1">MGSGAGVLRALLLLLDVGGAQVLATGKSAGAEIDIKYALIGTALGVAISAGFLALKICMIRRRLFDDYSSDLRSAHQAPSDATLLKKRAPRLNLHFSERDARVIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3A6</accession>
    <name>A0A8C5Y3A6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Src kinase-associated phosphoprotein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Src family-associated phosphoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SKAP1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020109">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020110">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020111">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621480.1">
        <property type="nucleotide sequence ID" value="XM_012766026.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3A6"/>
    <dbReference type="Ensembl" id="ENSMICT00000058864.1">
        <property type="protein sequence ID" value="ENSMICP00000045138.1"/>
        <property type="gene ID" value="ENSMICG00000047158.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872171"/>
    <dbReference type="CTD" id="8631"/>
    <dbReference type="GeneTree" id="ENSGT00390000017856"/>
    <dbReference type="OrthoDB" id="243840at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001772">
        <property type="term" value="C:immunological synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044853">
        <property type="term" value="C:plasma membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002821">
        <property type="term" value="P:positive regulation of adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033634">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001954">
        <property type="term" value="P:positive regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034116">
        <property type="term" value="P:positive regulation of heterotypic cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033625">
        <property type="term" value="P:positive regulation of integrin activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903039">
        <property type="term" value="P:positive regulation of leukocyte cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13380">
        <property type="entry name" value="PH_Skap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12044">
        <property type="entry name" value="SH3_SKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000097">
        <property type="entry name" value="Putative src kinase-associated phosphoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000277">
        <property type="entry name" value="src kinase-associated phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035765">
        <property type="entry name" value="SKAP1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF1">
        <property type="entry name" value="SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="107"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="364" mass="42332" checksum="C90E79121F7445C7" modified="2022-01-19" version="1">MQAVDLPEEICWLLEDTEEFLAEGLRNENLSTVARDHRDHILRGFQQIKTRYCWDFQPQGGDLGQDSFDDNHSGTLGLSLTSDARFLSDYQEEGTEDILRGAQELDNIIKQGYLEKKSKDHSFFGSEWQKRWCVVSRSLFYYYANEKSKQPKGTFLIKGYSVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPCEEEEEEEEEEEEEREEEMYDDIDGFDSANSGSQCRPIILPGNVGIKEPTEENEEEIYEVLPDEEHDLEEDESGTRRKGVDSANYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNNLIGIVPKEYLTSAFEVEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3E1</accession>
    <name>A0A8C5Y3E1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003754">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3E1"/>
    <dbReference type="Ensembl" id="ENSMICT00000061935.1">
        <property type="protein sequence ID" value="ENSMICP00000045248.1"/>
        <property type="gene ID" value="ENSMICG00000041853.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01050000244871"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000942">
        <property type="entry name" value="Immunoglobulin heavy variable 3-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="11" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="106" mass="11907" checksum="064C8AA715E129E5" modified="2022-01-19" version="1">EVQLVESGGGLVQPGGSLRLSCAASGFTFSDYWMNWVRQAPGKGLEWVAHIRYDGSKQYYADAVKGRFTISRDNSKNSLYLQMNSLRAEDTALYYCARDTVRGDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3G4</accession>
    <name>A0A8C5Y3G4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024686">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3G4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059821.1">
        <property type="protein sequence ID" value="ENSMICP00000045222.1"/>
        <property type="gene ID" value="ENSMICG00000041968.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161640"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001920">
        <property type="entry name" value="Immunoglobulin lambda variable 6-57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="108" mass="11698" checksum="A0E052299A5C7872" modified="2022-01-19" version="1">NLVLTQPSSVSGSPGQKVTLSCTRSSGNIGSYYVHWYQQRPGSAPSTVIYEDNERPSGVPDRFSGSIDSSSNSASLTISGLQSEDEADYYCQSYDDSYNHTVLQTMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y517</accession>
    <name>A0A8C5Y517_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y517"/>
    <dbReference type="Ensembl" id="ENSMICT00000070160.1">
        <property type="protein sequence ID" value="ENSMICP00000046021.1"/>
        <property type="gene ID" value="ENSMICG00000045283.1"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="51" mass="5832" checksum="1A5FAAAC918CE17E" modified="2022-01-19" version="1">MRIYTWHSVFCIDLPTFRAPAMVVSSLCFLSLLLVILELSTDSSAQLLYHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y866</accession>
    <name>A0A8C5Y866_MICMU</name>
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        <recommendedName>
            <fullName evidence="8 18">Podocalyxin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17 18">Podocalyxin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PODXL</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 18">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell projection</location>
            <location evidence="6">Filopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 18">Cell projection</location>
            <location evidence="2 18">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Membrane raft</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Cell projection</location>
            <location evidence="18">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <topology evidence="5">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 18">Belongs to the podocalyxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y866"/>
    <dbReference type="Ensembl" id="ENSMICT00000062988.1">
        <property type="protein sequence ID" value="ENSMICP00000046858.1"/>
        <property type="gene ID" value="ENSMICG00000042010.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111314"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030175">
        <property type="term" value="C:filopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031528">
        <property type="term" value="C:microvillus membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022408">
        <property type="term" value="P:negative regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033634">
        <property type="term" value="P:positive regulation of cell-cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032534">
        <property type="term" value="P:regulation of microvillus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013836">
        <property type="entry name" value="CD34/Podocalyxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017403">
        <property type="entry name" value="PODXL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12067">
        <property type="entry name" value="PODOCALYXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12067:SF5">
        <property type="entry name" value="PODOCALYXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06365">
        <property type="entry name" value="CD34_antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038143">
        <property type="entry name" value="Podocalyxin-like_p1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9 18" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16 18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="10 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="426"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="20"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="181"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00017371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="520" mass="53511" checksum="034EF3682903692A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAF4</accession>
    <name>A0A8C5YAF4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC105862670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAF4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059421.1">
        <property type="protein sequence ID" value="ENSMICP00000048524.1"/>
        <property type="gene ID" value="ENSMICG00000041845.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154757"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070492">
        <property type="term" value="F:oligosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146">
        <property type="entry name" value="INTELECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16146:SF38">
        <property type="entry name" value="INTELECTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034087623" evidence="2">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="271" mass="30416" checksum="229C40B0EB5A0BB5" modified="2022-01-19" version="1">MNQLGFLLFLIVATRGWSEEVANTFSQKGSCSSASPSLPRSCKEIKSRVPQWLVFLCTKNGLIYQTFSGSRSSYPEGDNNWPTKHLWSAEAAQNPGYYDIQAQDLSIWHVPNNSPLEHWRNSSLLRYHTDIGFLQRLGHNLFGLYQKFPVKYGEGTCWKDNGPAIPVVYDFGDAQKTASYYSPNGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGFFPEANPRQCGDFSSFDWNGYGTHVGYSTSREITEAAVLLFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHK0</accession>
    <name>A0A8C5YHK0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Solute carrier family 25 member 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC25A36</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>UTP(in) + CTP(out) = UTP(out) + CTP(in)</text>
            <dbReference type="Rhea" id="RHEA:73531"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000672">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617754.1">
        <property type="nucleotide sequence ID" value="XM_012762300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHK0"/>
    <dbReference type="Ensembl" id="ENSMICT00000072379.1">
        <property type="protein sequence ID" value="ENSMICP00000051175.1"/>
        <property type="gene ID" value="ENSMICG00000048906.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870037"/>
    <dbReference type="KEGG" id="mmur:105870037"/>
    <dbReference type="CTD" id="55186"/>
    <dbReference type="GeneTree" id="ENSGT00940000154369"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000074">
        <property type="entry name" value="Solute carrier family 25 member 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000124">
        <property type="entry name" value="Solute carrier family 25 member 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="116"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="224"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="34260" checksum="D38E02B8B3DB9CE9" modified="2022-01-19" version="1">MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVHLNTMAGASVNRVVSPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNGVFDPDSTQVHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGEKRMGAFECVRKVYQTDGLRGFYRGMSASYAGISETVIHFVIYESIKQKLLEYKIASTMENEEESVKEASDFVGMMLAAATSKTCATTIAYPHEVIRTRLREEGTKYRSFFQTLSLVVQEEGYGSLYRGLTTHLVRQIPNTAIMMATYELVVYLLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJ65</accession>
    <name>A0A8C5YJ65_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Integrin beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ITGB5</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterodimer of an alpha and a beta subunit. Beta-5 (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10. Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5 (via N-terminus). ITGAV:ITGB5 interacts with CCN3. Interacts with tensin TNS3; TNS3 also interacts with PEAK1, thus acting as an adapter molecule to bridge the association of PEAK1 with ITGB5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 22">Cell membrane</location>
            <topology evidence="1 22">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the integrin beta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001082">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001083">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000324">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YJE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000072558.1">
        <property type="protein sequence ID" value="ENSMICP00000051287.1"/>
        <property type="gene ID" value="ENSMICG00000049292.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158391"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677:SF1">
        <property type="entry name" value="ACIDIC AMINO ACID DECARBOXYLASE GADL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45677">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="320" mass="35898" checksum="436261D0DD29DECE" modified="2022-01-19" version="1">DNDQQEMVPSKKTAVLVDGIVLNGPTTDAKAGEKFVEEACRLIMEEVVLKATDVNEKVCEWRPPEQLKELLDLEMRDTGEPPHRLLELCRDVIRYSVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGDGIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGLPRLILFTSAECHYSMKKAASFLGIGTENVCFVGTDGRGKMLPEELEKQVWQAKKEGAAPFLVCATSGTTVLGAFDPLDDIADICERHGLWLHVDASWGGSALMSRKHRKLLHGIHRADSVAWNPHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EIT8</accession>
    <name>A0A8C6EIT8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein dispatched homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DISP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the dispatched family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621867.1">
        <property type="nucleotide sequence ID" value="XM_012766413.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070020.1">
        <property type="protein sequence ID" value="ENSMICP00000045590.1"/>
        <property type="gene ID" value="ENSMICG00000027535.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105872440"/>
    <dbReference type="CTD" id="85455"/>
    <dbReference type="GeneTree" id="ENSGT00940000159551"/>
    <dbReference type="OrthoDB" id="193905at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000011">
        <property type="entry name" value="Dispatched RND transporter family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000026">
        <property type="entry name" value="Dispatched RND transporter family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052081">
        <property type="entry name" value="Dispatched_Hh_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951:SF2">
        <property type="entry name" value="PROTEIN DISPATCHED HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45951">
        <property type="entry name" value="PROTEIN DISPATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="954"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="11">
        <location>
            <begin position="506"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1157"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1283"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1352"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1220"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1244"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1283"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1389" mass="151209" checksum="A2A4630A6E0BED76" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKD9</accession>
    <name>A0A8C6EKD9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type-1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKD9"/>
    <dbReference type="Ensembl" id="ENSMICT00000039446.2">
        <property type="protein sequence ID" value="ENSMICP00000048951.1"/>
        <property type="gene ID" value="ENSMICG00000034102.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074855"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000063">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26071" checksum="CC8A4984452D3A79" modified="2022-01-19" version="1">MEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISTAGLTADARLLCNIMRQECLDSRFVFDRPPPVSRLVSLIGSKTQIPTQRHGRRLYGVGLLIAGYDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQNPTTKNVPSGIVGKDLEFTIYDDDVSPFLEGLEERPQGKAQPAQPADEPAEKADEPMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKW8</accession>
    <name>A0A8C6EKW8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">L antigen family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105882039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140773.1">
        <property type="nucleotide sequence ID" value="XM_020285184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKW8"/>
    <dbReference type="Ensembl" id="ENSMICT00000061533.1">
        <property type="protein sequence ID" value="ENSMICP00000049324.1"/>
        <property type="gene ID" value="ENSMICG00000041505.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105882039"/>
    <dbReference type="GeneTree" id="ENSGT00410000025802"/>
    <dbReference type="OrthoDB" id="9629153at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="171" mass="17679" checksum="B1BDC01FE842AA4B" modified="2022-01-19" version="1">MPAPDAGAAGGTGGQRGRDGSRDGQGGSRDGQGDPNGQGGAGAAGGARVAGSNAGSISCVPARGQGAEPVPADRRPGIQLNEFTLTVPFPSPLEAEIARRSLAPYEEPHQQAIHKEFTVNGSLLIVRWTAEDAHLLRISFISFLDQLSLMLRTMRRFGPLLCPNSLPGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKZ4</accession>
    <name>A0A8C6EKZ4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AKT1 substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">AKT1S1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKZ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059373.1">
        <property type="protein sequence ID" value="ENSMICP00000049480.1"/>
        <property type="gene ID" value="ENSMICG00000044841.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017397"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030291">
        <property type="term" value="F:protein serine/threonine kinase inhibitor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045792">
        <property type="term" value="P:negative regulation of cell size"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of translational initiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of translational initiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043523">
        <property type="term" value="P:regulation of neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026682">
        <property type="entry name" value="AKT1S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055192">
        <property type="entry name" value="PRAS_NT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21844">
        <property type="entry name" value="AKT1 SUBSTRATE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21844:SF2">
        <property type="entry name" value="PROLINE-RICH AKT1 SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15798">
        <property type="entry name" value="PRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22911">
        <property type="entry name" value="PRAS_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline-rich AKT1 substrate 1 N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="274" mass="29244" checksum="794707C1D890D5C6" modified="2022-01-19" version="1">MSFEGGDGAWPAMLATGTARMASGRPEELWEAVVGAAERFRARTGTELVLLTAAPPPRPGPCAYAAHGRGALAEAARRCLHDIALAHRAAAAARPPAPPPAPQPPSPAPSPPRPALAREDDEEDEDEQTETETSGERLGVSDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPSYSVPPASALPTQQYAKSLPVSVPVWAFKEKRTEARSSDEENGQPSSPDLDRIAASMRALVLREAEDTQVFGDLPRPRLNTSDFQKLKRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EBE1</accession>
    <name>A0A8B7EBE1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit</fullName>
            <ecNumber evidence="5">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">O-GlcNAc transferase subunit p110</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">O-linked N-acetylglucosamine transferase 110 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">OGT</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03033684">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591637.1">
        <property type="nucleotide sequence ID" value="XM_012736183.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EBE1"/>
    <dbReference type="Ensembl" id="ENSMICT00000032524.2">
        <property type="protein sequence ID" value="ENSMICP00000034750.1"/>
        <property type="gene ID" value="ENSMICG00000003078.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855308"/>
    <dbReference type="KEGG" id="mmur:105855308"/>
    <dbReference type="CTD" id="8473"/>
    <dbReference type="GeneTree" id="ENSGT00940000155085"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017122">
        <property type="term" value="C:protein N-acetylglucosaminyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160076">
        <property type="term" value="P:negative regulation of non-canonical inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032435">
        <property type="term" value="P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160075">
        <property type="term" value="P:non-canonical inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120162">
        <property type="term" value="P:positive regulation of cold-induced thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046889">
        <property type="term" value="P:positive regulation of lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061462">
        <property type="term" value="P:protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein processing"/>
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        <property type="term" value="P:pyroptotic inflammatory response"/>
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        <property type="term" value="P:regulation of gluconeogenesis"/>
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        <property type="term" value="P:regulation of glycolytic process"/>
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    <dbReference type="GO" id="GO:0046626">
        <property type="term" value="P:regulation of insulin receptor signaling pathway"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0098696">
        <property type="term" value="P:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035020">
        <property type="term" value="P:regulation of Rac protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051963">
        <property type="term" value="P:regulation of synapse assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032868">
        <property type="term" value="P:response to insulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000013">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000019">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.150:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000001">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000012">
        <property type="entry name" value="UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037919">
        <property type="entry name" value="OGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44366:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 22" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="293"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="361"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="22">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="23">
        <location>
            <begin position="476"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116953" checksum="1C9DBD88FCC3280F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EEX2</accession>
    <name>A0A8B7EEX2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Huntingtin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17 19" type="primary">HTT</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="19">Liver</tissue>
        </source>
    </reference>
    <reference evidence="17" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in microtubule-mediated transport or vesicle function.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Promotes the formation of autophagic vesicles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with PFN1. Interacts through its N-terminus with PRPF40A. Interacts with PQBP1. Interacts with SETD2. Interacts with SH3GLB1. Interacts with SYVN. Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Interacts with F8A1/F8A2/F8A3. Found in a complex with F8A1/F8A2/F8A3, HTT and RAB5A; mediates the recruitment of HTT by RAB5A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the huntingtin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021813">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592809.1">
        <property type="nucleotide sequence ID" value="XM_012737355.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000006928.3">
        <property type="protein sequence ID" value="ENSMICP00000006312.2"/>
        <property type="gene ID" value="ENSMICG00000006879.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856002"/>
    <dbReference type="CTD" id="3064"/>
    <dbReference type="GeneTree" id="ENSGT00390000015863"/>
    <dbReference type="OrthoDB" id="10065698at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016234">
        <property type="term" value="C:inclusion body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <sequence length="3123" mass="345891" checksum="627B35305363EECE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EML1</accession>
    <name>A0A8B7EML1_MICMU</name>
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        <submittedName>
            <fullName evidence="8">Small G protein signaling modulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SGSM2</name>
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    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RUTBC family.</text>
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        <property type="component" value="Chromosome 16"/>
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        <property type="term" value="C:melanosome"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd15784">
        <property type="entry name" value="PH_RUTBC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
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        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
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        <property type="entry name" value="Rab-GAP-TBC_dom"/>
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        <property type="entry name" value="Rab-GAP_TBC_sf"/>
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        <property type="entry name" value="Run_dom"/>
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        <property type="entry name" value="Run_dom_sf"/>
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        <property type="entry name" value="RUN_SGSM2"/>
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    <dbReference type="InterPro" id="IPR037745">
        <property type="entry name" value="SGSM1/2"/>
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    <dbReference type="InterPro" id="IPR021935">
        <property type="entry name" value="SGSM1/2_RBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF194">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12068">
        <property type="entry name" value="PH_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02759">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00593">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140741">
        <property type="entry name" value="RUN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50826">
        <property type="entry name" value="RUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RUN" evidence="7">
        <location>
            <begin position="34"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="6">
        <location>
            <begin position="611"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1052" mass="118884" checksum="F8063229744B01CB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EMV5</accession>
    <name>A0A8B7EMV5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rho GTPase-activating protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Rho-type GTPase-activating protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">START domain-containing protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">StAR-related lipid transfer protein 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DLC1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration. Interacts with tensin TNS1 (via N-terminus); the interaction is decreased by phosphorylation of TNS1. Interacts with TNS3 and PTEN; in resting cells, interacts with TNS3 (via C2 tensin-type domain) but, following growth factor stimulation, TNS3 and PTEN are phosphorylated which leads to weakened interaction with TNS3 and enhanced interaction with PTEN. Interacts (via C-terminus) with tensin TNS4 (via SH2 domain); the interaction is independent of tyrosine phosphorylation of DLC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03023811">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595267.1">
        <property type="nucleotide sequence ID" value="XM_012739813.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EMV5"/>
    <dbReference type="Ensembl" id="ENSMICT00000062127.1">
        <property type="protein sequence ID" value="ENSMICP00000045914.1"/>
        <property type="gene ID" value="ENSMICG00000012925.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857445"/>
    <dbReference type="CTD" id="10395"/>
    <dbReference type="GeneTree" id="ENSGT00950000183061"/>
    <dbReference type="OrthoDB" id="10003330at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005901">
        <property type="term" value="C:caveola"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042169">
        <property type="term" value="F:SH2 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051895">
        <property type="term" value="P:negative regulation of focal adhesion assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of Rho protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900119">
        <property type="term" value="P:positive regulation of execution phase of apoptosis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="CDD" id="cd04375">
        <property type="entry name" value="RhoGAP_DLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09591">
        <property type="entry name" value="SAM_DLC1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="rho GTPase-activating protein 7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000007">
        <property type="entry name" value="rho GTPase-activating protein 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="StAR-related lipid transfer domain-containing 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12659">
        <property type="entry name" value="RHO-TYPE GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="15">
        <location>
            <begin position="675"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="16">
        <location>
            <begin position="911"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="324"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="416"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="525"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="547"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1125" mass="126838" checksum="E203AEF03799CE04" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EX49</accession>
    <name>A0A8B7EX49_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ATP6V0C</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4. Interacts with LASS2. Interacts with RNF182; this interaction leads to ubiquitination and degradation via the proteasome pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasmic vesicle</location>
            <location evidence="9">Clathrin-coated vesicle membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Vacuole membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020803">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599132.1">
        <property type="nucleotide sequence ID" value="XM_012743678.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EX49"/>
    <dbReference type="Ensembl" id="ENSMICT00000064535.1">
        <property type="protein sequence ID" value="ENSMICP00000045328.1"/>
        <property type="gene ID" value="ENSMICG00000043687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105859675"/>
    <dbReference type="KEGG" id="mmur:105859675"/>
    <dbReference type="CTD" id="527"/>
    <dbReference type="GeneTree" id="ENSGT00550000074873"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="16"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="92"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="154" mass="15705" checksum="64A38A3EEEDD7CA4" modified="2022-01-19" version="1">MSESKSPEYASFFAVMGASSAMIFSALGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANSLNEGINLYRSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EZH7</accession>
    <name>A0A8B7EZH7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 14">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TIMM23B</name>
        <name evidence="15" type="synonym">TIMM23</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has a role in the activation of stress-induced mitophagy by protecting PINK1 from OMA1-mediated degradation and facilitating its accumulation at the outer mitochondrial membrane in response to depolarization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50; within this complex, directly interacts with TIMM50. The complex interacts with the TIMM44 component of the PAM complex and with DNAJC15. Upon mitochondrial depolarization, interacts with PINK1; the interaction is required for PINK1 accumulation at the outer mitochondrial membrane, kinase activation by autophosphorylation and PRKN recruitement to mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EZH7"/>
    <dbReference type="Ensembl" id="ENSMICT00000067208.1">
        <property type="protein sequence ID" value="ENSMICP00000043904.1"/>
        <property type="gene ID" value="ENSMICG00000007229.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001094"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005681">
        <property type="entry name" value="Tim23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00983">
        <property type="entry name" value="3a0801s02tim23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF39">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="209" mass="21897" checksum="73D992E4EA32A5F1" modified="2022-01-19" version="1">MEGGGGSGNKTTGGLAGFFGASGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAVNGLRLGLKETQNMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGVARGGLAGLTLTSLYALYNNWEHMKGSLLQQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F229</accession>
    <name>A0A8B7F229_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">ATP-dependent RNA helicase TDRD9</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Tudor domain-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TDRD9</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with piRNA-associated proteins PIWIL1 and PIWIL4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03003713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003714">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601921.1">
        <property type="nucleotide sequence ID" value="XM_012746467.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000000427.3">
        <property type="protein sequence ID" value="ENSMICP00000000392.3"/>
        <property type="gene ID" value="ENSMICG00000000428.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861131"/>
    <dbReference type="CTD" id="122402"/>
    <dbReference type="GeneTree" id="ENSGT00940000157035"/>
    <dbReference type="OrthoDB" id="66977at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071547">
        <property type="term" value="C:piP-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009566">
        <property type="term" value="P:fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007141">
        <property type="term" value="P:male meiosis I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141196">
        <property type="term" value="P:transposable element silencing by piRNA-mediated DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141006">
        <property type="term" value="P:transposable element silencing by piRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20431">
        <property type="entry name" value="Tudor_TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000073">
        <property type="entry name" value="ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001113">
        <property type="entry name" value="ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000012">
        <property type="entry name" value="putative ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000946">
        <property type="entry name" value="putative ATP-dependent RNA helicase TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000016">
        <property type="entry name" value="Tudor domain containing 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047384">
        <property type="entry name" value="Tudor_TDRD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF113">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE TDRD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="12" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="142"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="377"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="21">
        <location>
            <begin position="944"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00074173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000392.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1382" mass="155568" checksum="0E17A5A858DB3B02" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F273</accession>
    <name>A0A8B7F273_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cadherin-related family member 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Cadherin-like protein 28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CDHR3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015361">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015362">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601968.1">
        <property type="nucleotide sequence ID" value="XM_012746514.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F273"/>
    <dbReference type="Ensembl" id="ENSMICT00000010974.3">
        <property type="protein sequence ID" value="ENSMICP00000009993.3"/>
        <property type="gene ID" value="ENSMICG00000010974.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068090.1">
        <property type="protein sequence ID" value="ENSMICP00000047620.1"/>
        <property type="gene ID" value="ENSMICG00000010974.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861133"/>
    <dbReference type="CTD" id="222256"/>
    <dbReference type="GeneTree" id="ENSGT00940000161245"/>
    <dbReference type="OrthoDB" id="9047765at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="Cadherin related family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000237">
        <property type="entry name" value="Cadherin related family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000244">
        <property type="entry name" value="Cadherin related family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000250">
        <property type="entry name" value="Cadherin related family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000281">
        <property type="entry name" value="Cadherin related family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050971">
        <property type="entry name" value="Cadherin-domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025:SF30">
        <property type="entry name" value="CADHERIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24025">
        <property type="entry name" value="DESMOGLEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044664202" description="Cadherin-related family member 3" evidence="17">
        <location>
            <begin position="20"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="710"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="136"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="346"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="462"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="18">
        <location>
            <begin position="567"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="829"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="858"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009993.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="884" mass="96821" checksum="BCF5181A7986EABA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6Y1</accession>
    <name>A0A8B7F6Y1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hdc homolog, cell cycle regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">HECA</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03008459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneTree" id="ENSGT00500000044928"/>
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        <property type="entry name" value="HEADCASE PROTEIN HOMOLOG"/>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
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        <name evidence="15" type="primary">WNK1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
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    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
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            <dbReference type="ChEBI" id="CHEBI:30013"/>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
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        <subcellularLocation>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
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        <property type="entry name" value="Serine/threonine-protein kinase WNK1 isoform 2"/>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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        <location>
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            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1342"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1360"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2121"/>
            <end position="2137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2139"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2288"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="2375"/>
            <end position="2387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2396"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2428"/>
            <end position="2452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="2468"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2482"/>
            <end position="2497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2635" mass="279224" checksum="0AFAAC0A16CE202F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FB89</accession>
    <name>A0A8B7FB89_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 18">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SSRP1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with MYOG (via C-terminal region). Component of the FACT complex, a stable heterodimer of SSRP1 and SUPT16H. Also a component of a CK2-SPT16-SSRP1 complex which forms following UV irradiation, composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B. Binds to histone H3-H4 tetramers, but not to intact nucleosomes. Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1. Interacts with isoform gamma of TP63. Interacts with FYTTD1/UIF. Interacts with SRF. Interacts with NEK9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the SSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605397.1">
        <property type="nucleotide sequence ID" value="XM_012749943.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605399.1">
        <property type="nucleotide sequence ID" value="XM_012749945.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FB89"/>
    <dbReference type="Ensembl" id="ENSMICT00000004836.3">
        <property type="protein sequence ID" value="ENSMICP00000004407.2"/>
        <property type="gene ID" value="ENSMICG00000004836.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065136.1">
        <property type="protein sequence ID" value="ENSMICP00000048195.1"/>
        <property type="gene ID" value="ENSMICG00000004836.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863146"/>
    <dbReference type="CTD" id="6749"/>
    <dbReference type="GeneTree" id="ENSGT00940000157117"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902275">
        <property type="term" value="P:regulation of chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21994">
        <property type="entry name" value="HMG-box_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000032">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.220:FF:000001">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000098">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000119">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048985">
        <property type="entry name" value="SSRP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21092">
        <property type="entry name" value="SSRP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 18" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 18" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15 17 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 18" id="KW-0804">Transcription</keyword>
    <keyword evidence="11 18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HMG box" evidence="20">
        <location>
            <begin position="547"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="17">
        <location>
            <begin position="547"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="458"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="470"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="515"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="577"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="643"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="697"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00065079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004407.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="710" mass="81224" checksum="9FF9E50370F04412" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FEI6</accession>
    <name>A0A8B7FEI6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sushi domain-containing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SUSD4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021158">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021159">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021160">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606681.1">
        <property type="nucleotide sequence ID" value="XM_012751227.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606682.1">
        <property type="nucleotide sequence ID" value="XM_012751228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FEI6"/>
    <dbReference type="Ensembl" id="ENSMICT00000004905.3">
        <property type="protein sequence ID" value="ENSMICP00000004472.3"/>
        <property type="gene ID" value="ENSMICG00000004902.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000048745.2">
        <property type="protein sequence ID" value="ENSMICP00000030444.1"/>
        <property type="gene ID" value="ENSMICG00000004902.3"/>
    </dbReference>
    <dbReference type="CTD" id="55061"/>
    <dbReference type="GeneTree" id="ENSGT00940000160410"/>
    <dbReference type="OrthoDB" id="7487745at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098688">
        <property type="term" value="C:parallel fiber to Purkinje cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045957">
        <property type="term" value="P:negative regulation of complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045959">
        <property type="term" value="P:negative regulation of complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099149">
        <property type="term" value="P:regulation of postsynaptic neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000030">
        <property type="entry name" value="Sushi domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000063">
        <property type="entry name" value="Sushi domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.10:FF:000121">
        <property type="entry name" value="Sushi domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042985">
        <property type="entry name" value="SUSD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47007">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47007:SF1">
        <property type="entry name" value="SUSHI DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0768">Sushi</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="15">
        <location>
            <begin position="239"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="398"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="12">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="488" mass="53596" checksum="A3940987E4C03EC8" modified="2022-01-19" version="1">MYHGMNPSNGDGFLEPQRQQPQCPQRLLAVILWFQLALCFGPAQLTGGFDDLHVCADPGVPENGFRTPSAGVFFESSVTRFHCQDGFKLKGSTKRLCMKHFNGTLGWIPSDRPICVQENCRIPQIEDAEIHNKTYRLGDKLVITCHEGFKIRYPDLYNLVSLCREDGMWDNLPICQGCLRPLASSNGYVNISEFQTSFPVGTVVAYRCFPGFKLEGSEYLECLHSLTWSSSPPRCLALEVCPLPPTVSHGDFVCHPRPCQRYSHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAVSGSLRALGPSYLASVGQGCPVPGDDQSPPAYPGSEDTDRGTGESETCDSVSGSSELIQSLCSPPECQEGPHPAPDNPATIASTAGQVASTSPGIDIADEIPLMEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FFS4</accession>
    <name>A0A8B7FFS4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat domain 47</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">WDR47</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
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                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
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                <person name="Worley K.C."/>
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                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018526">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609077.1">
        <property type="nucleotide sequence ID" value="XM_012753623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FKD1"/>
    <dbReference type="Ensembl" id="ENSMICT00000060119.1">
        <property type="protein sequence ID" value="ENSMICP00000044555.1"/>
        <property type="gene ID" value="ENSMICG00000042371.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105865201"/>
    <dbReference type="KEGG" id="mmur:105865201"/>
    <dbReference type="CTD" id="100113407"/>
    <dbReference type="GeneTree" id="ENSGT00940000160424"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 170B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="132" mass="14374" checksum="CF7D091F123B4A48" modified="2022-01-19" version="1">MKAEGGDHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISLIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTIIISFSRILATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="2">Transmembrane protein 156</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM156</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Gray mouse lemur</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03023190">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609443.1">
        <property type="nucleotide sequence ID" value="XM_012753989.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FLD9"/>
    <dbReference type="Ensembl" id="ENSMICT00000009708.3">
        <property type="protein sequence ID" value="ENSMICP00000008839.2"/>
        <property type="gene ID" value="ENSMICG00000009711.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865425"/>
    <dbReference type="KEGG" id="mmur:105865425"/>
    <dbReference type="CTD" id="80008"/>
    <dbReference type="GeneTree" id="ENSGT00390000017929"/>
    <dbReference type="OrthoDB" id="9422827at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029374">
        <property type="entry name" value="TMEM156"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14788">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14788:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15106">
        <property type="entry name" value="TMEM156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008839.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="296" mass="34372" checksum="5FE645F5D638C91B" modified="2022-01-19" version="1">MTKTALLKLFVAIVITFILILPEYFKTSEERILELSCLEVCLQPNFNYSLSYLNFSFVTFPQPVRETQIIMGIFLNHSNCQNFTRIYQDITSEFKMCSSCLVCESKGNMDFISQEQTSKVLIMRGSTEVKANDFHSPCQHFNFTVAPLVDHLEEYDTFCNLKSHTRKSAIMEEEPTKEKPTNDTCRITKYLNNCIHVSLHLEMDVKNVICSMKITWYVLVLLVFIFLIILIFHKILEGRRRVQKWQSHRYKTPSVLLRGSDSEKPRARAARVAPVETTQRLPLAHVKEKLPPLPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FNN2</accession>
    <name>A0A8B7FNN2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dickkopf like acrosomal protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">DKKL1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609894.1">
        <property type="nucleotide sequence ID" value="XM_012754440.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609895.1">
        <property type="nucleotide sequence ID" value="XM_012754441.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FNN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000009285.3">
        <property type="protein sequence ID" value="ENSMICP00000008458.2"/>
        <property type="gene ID" value="ENSMICG00000009288.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000028097.2">
        <property type="protein sequence ID" value="ENSMICP00000025372.2"/>
        <property type="gene ID" value="ENSMICG00000009288.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865673"/>
    <dbReference type="KEGG" id="mmur:105865673"/>
    <dbReference type="CTD" id="27120"/>
    <dbReference type="GeneTree" id="ENSGT00390000014026"/>
    <dbReference type="OrthoDB" id="6359792at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039706">
        <property type="term" value="F:co-receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048019">
        <property type="term" value="F:receptor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000225">
        <property type="term" value="P:negative regulation of testosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007341">
        <property type="term" value="P:penetration of zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045600">
        <property type="term" value="P:positive regulation of fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23006">
        <property type="entry name" value="Dkkl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039863">
        <property type="entry name" value="DKK1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049632">
        <property type="entry name" value="DKKL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113:SF7">
        <property type="entry name" value="DICKKOPF-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12113">
        <property type="entry name" value="DICKKOPF3-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044664207" evidence="4">
        <location>
            <begin position="22"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008458.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="232" mass="26483" checksum="CFFD625E2DA2DDC3" modified="2022-01-19" version="1">MWQPLVLLLLLPSALVSPSTAAPIRYADAQESSLGLLGLQNLLQSFSRLFLKDDLFRGMDSFFSAPMDFRGLPRNYHQEENQERRLGNNTLSSHLQIDKVTDNKTGEVLISEKVVASIQPAEGSLEGDWKVPKMEEKEALLPLRKAMDSLHPEPHPRVAFWIMKLPRRKPHHDAPEGSHWLSEKRHRLQAIRDGLREGTREDSEEGTQGSSHVKLPARKTHFLYIFRPSQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FQP3</accession>
    <name>A0A8B7FQP3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FERM, ARHGEF and pleckstrin domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">FERM, RhoGEF and pleckstrin domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">FARP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding. Interacts with RAC1.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611063.1">
        <property type="nucleotide sequence ID" value="XM_012755609.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611064.1">
        <property type="nucleotide sequence ID" value="XM_012755610.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FQP3"/>
    <dbReference type="Ensembl" id="ENSMICT00000029299.2">
        <property type="protein sequence ID" value="ENSMICP00000029043.2"/>
        <property type="gene ID" value="ENSMICG00000012071.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866377"/>
    <dbReference type="KEGG" id="mmur:105866377"/>
    <dbReference type="CTD" id="9855"/>
    <dbReference type="GeneTree" id="ENSGT00940000158642"/>
    <dbReference type="OrthoDB" id="9990815at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022405">
        <property type="term" value="P:hair cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030316">
        <property type="term" value="P:osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071800">
        <property type="term" value="P:podosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033623">
        <property type="term" value="P:regulation of integrin activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13193">
        <property type="entry name" value="FERM_C_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17190">
        <property type="entry name" value="FERM_F1_FARP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01220">
        <property type="entry name" value="PH1_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13235">
        <property type="entry name" value="PH2_FARP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000040">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000005">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000046">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000020">
        <property type="entry name" value="FERM, RhoGEF and pleckstrin domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041788">
        <property type="entry name" value="FARP1/FARP2/FRMD7_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051835">
        <property type="entry name" value="RAC1-GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858">
        <property type="entry name" value="FERM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45858:SF4">
        <property type="entry name" value="FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="FERM" evidence="12">
        <location>
            <begin position="44"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="537"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="757"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="931"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1027"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="482"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1054"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00063142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029043.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121003" checksum="03A4767CE6268596" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FZP6</accession>
    <name>A0A8B7FZP6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ezrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">EZR</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Microvillus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03008630">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615088.1">
        <property type="nucleotide sequence ID" value="XM_012759634.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FZP6"/>
    <dbReference type="Ensembl" id="ENSMICT00000045827.2">
        <property type="protein sequence ID" value="ENSMICP00000016804.1"/>
        <property type="gene ID" value="ENSMICG00000009498.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868598"/>
    <dbReference type="KEGG" id="mmur:105868598"/>
    <dbReference type="CTD" id="7430"/>
    <dbReference type="GeneTree" id="ENSGT01020000230354"/>
    <dbReference type="OrthoDB" id="6018897at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061028">
        <property type="term" value="P:establishment of endothelial barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000643">
        <property type="term" value="P:positive regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902966">
        <property type="term" value="P:positive regulation of protein localization to early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902115">
        <property type="term" value="P:regulation of organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13194">
        <property type="entry name" value="FERM_C_ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17239">
        <property type="entry name" value="FERM_F1_Ezrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000003">
        <property type="entry name" value="Radixin isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000002">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000013">
        <property type="entry name" value="radixin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.450:FF:000001">
        <property type="entry name" value="radixin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011174">
        <property type="entry name" value="ERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011259">
        <property type="entry name" value="ERM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041789">
        <property type="entry name" value="ERM_FERM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046810">
        <property type="entry name" value="ERM_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000798">
        <property type="entry name" value="Ez/rad/moesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008954">
        <property type="entry name" value="Moesin_tail_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23281">
        <property type="entry name" value="MERLIN/MOESIN/EZRIN/RADIXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00769">
        <property type="entry name" value="ERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20492">
        <property type="entry name" value="ERM_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09379">
        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002305">
        <property type="entry name" value="ERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00935">
        <property type="entry name" value="BAND41"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00661">
        <property type="entry name" value="ERMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00295">
        <property type="entry name" value="B41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48678">
        <property type="entry name" value="Moesin tail domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00660">
        <property type="entry name" value="FERM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00661">
        <property type="entry name" value="FERM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50057">
        <property type="entry name" value="FERM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM" evidence="11">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)</name>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="586" mass="69255" checksum="754C20B6E958ABEC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GRX9</accession>
    <name>A0A8B7GRX9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Collagenase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Matrix metalloproteinase-13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">MMP13</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="22">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006771">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626023.1">
        <property type="nucleotide sequence ID" value="XM_012770569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GRX9"/>
    <dbReference type="Ensembl" id="ENSMICT00000006323.3">
        <property type="protein sequence ID" value="ENSMICP00000005768.2"/>
        <property type="gene ID" value="ENSMICG00000006323.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874591"/>
    <dbReference type="KEGG" id="mmur:105874591"/>
    <dbReference type="CTD" id="4322"/>
    <dbReference type="GeneTree" id="ENSGT00940000157450"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030282">
        <property type="term" value="P:bone mineralization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003417">
        <property type="term" value="P:growth plate cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000007">
        <property type="entry name" value="Collagenase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000002">
        <property type="entry name" value="Matrix metallopeptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF165">
        <property type="entry name" value="COLLAGENASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 22" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0177">Collagen degradation</keyword>
    <keyword evidence="16 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 28" id="KW-0732">Signal</keyword>
    <keyword evidence="11 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="28">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133931" description="Collagenase 3" evidence="28">
        <location>
            <begin position="19"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="29">
        <location>
            <begin position="107"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="279"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="329"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="377"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="26">
        <location>
            <begin position="426"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="25">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="27">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="22">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="24">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="282"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005768.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="469" mass="53660" checksum="27D009717B68F254" modified="2022-01-19" version="1">MQGVLVAFLFLSWTHCRSLPLPDGDDDDLSEEDLQFAERYLKSYYHPPILAGILKKTSASSMVDRLREMQSFFGLEVTGKLDDNTLDIMKKPRCGVPDVGEYNVFPRTLKWTQTNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNLGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFVLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLVFFFRGRKFWALNGYDIMEGYPKKISELGFPKEVKKISAAVHFEDTGKTLFFSGNQVWRYDDTNQIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFSGPIQFEYSIWSNRIVRVMPTNSLLWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GX95</accession>
    <name>A0A8B7GX95_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">GalNAc alpha-2,6-sialyltransferase VI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">ST6GalNAc VI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Sialyltransferase 7F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ST6GALNAC6</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>3-O-[alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-alpha-D-GalNAc]-L-Ser-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-seryl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65280"/>
            <dbReference type="Rhea" id="RHEA-COMP:16760"/>
            <dbReference type="Rhea" id="RHEA-COMP:16761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:156395"/>
            <dbReference type="ChEBI" id="CHEBI:156397"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:65281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>3-O-[alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-alpha-D-GalNAc]-L-Thr-[protein] + CMP-N-acetyl-beta-neuraminate = a 3-O-{alpha-Neu5Ac-(2-&gt;3)-beta-D-Gal-(1-&gt;3)-[alpha-Neu5Ac-(2-&gt;6)]-alpha-D-GalNAc}-L-threonyl-[protein] + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65284"/>
            <dbReference type="Rhea" id="RHEA-COMP:16762"/>
            <dbReference type="Rhea" id="RHEA-COMP:16763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:156396"/>
            <dbReference type="ChEBI" id="CHEBI:156398"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:65285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2-&gt;3)-beta-D-galactosyl-(1-&gt;3)-[N-acetyl-alpha-neuraminosyl-(2-&gt;6)]-N-acetyl-beta-D-glucosaminyl-(1-&gt;3)-beta-D-galactosyl-(1-&gt;4)-beta-D-glucosyl-(1&lt;-&gt;1')-N-acyl-sphing-4-enine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:88073"/>
            <dbReference type="ChEBI" id="CHEBI:88079"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:47885"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41972"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78445"/>
            <dbReference type="ChEBI" id="CHEBI:78571"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:41973"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78568"/>
            <dbReference type="ChEBI" id="CHEBI:78569"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:41969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41976"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:78452"/>
            <dbReference type="ChEBI" id="CHEBI:78572"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41977"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a globoside MSGG + CMP-N-acetyl-beta-neuraminate = a globoside DSGG + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57812"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:140623"/>
            <dbReference type="ChEBI" id="CHEBI:140624"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:56089"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014907">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627482.1">
        <property type="nucleotide sequence ID" value="XM_012772028.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627483.1">
        <property type="nucleotide sequence ID" value="XM_012772029.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627484.1">
        <property type="nucleotide sequence ID" value="XM_012772030.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627485.1">
        <property type="nucleotide sequence ID" value="XM_012772031.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627486.1">
        <property type="nucleotide sequence ID" value="XM_012772032.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GX95"/>
    <dbReference type="Ensembl" id="ENSMICT00000043463.2">
        <property type="protein sequence ID" value="ENSMICP00000029847.1"/>
        <property type="gene ID" value="ENSMICG00000005699.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875231"/>
    <dbReference type="CTD" id="30815"/>
    <dbReference type="GeneTree" id="ENSGT00940000160114"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001665">
        <property type="term" value="F:alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009988">
        <property type="term" value="P:cell-cell recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001574">
        <property type="term" value="P:ganglioside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006677">
        <property type="term" value="P:glycosylceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23978">
        <property type="entry name" value="GT29_ST6GALNAC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000009">
        <property type="entry name" value="alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906">
        <property type="entry name" value="ALPHA-N-ACETYL-NEURAMINYL-2,3-BETA-GALACTOSYL-1, 3-N-ACETYL-GALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45906:SF6">
        <property type="entry name" value="ALPHA-N-ACETYLGALACTOSAMINIDE ALPHA-2,6-SIALYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0730">Sialic acid</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="74"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00053014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00074915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00080825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR005557-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="299" mass="34123" checksum="FE95CF6A7C605AA8" modified="2022-01-19" version="1">MSSNKEQRSAVFVILFALITILILYSSNSANEVFHHGSPRGHTRGPVNLKKWSMTDGYVPILGNKTLPSRCHRCVIISSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTFRVVAHSSVFRVLRRPQEFVNRTPEPVFIFWGPPDKMQKPQGSLVRVIQRAGLAFPNMEAYAVSPTRMHQFDDLFLGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNYCSQRSRLQRTPYHYYEPKGPDECVTYIQNEHSRKGNHHRFITEKRVFSSWAQLYGITFSHPSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GY43</accession>
    <name>A0A8B7GY43_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAD2L1 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">MAD2L1BP</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03007536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628544.1">
        <property type="nucleotide sequence ID" value="XM_012773090.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GY43"/>
    <dbReference type="Ensembl" id="ENSMICT00000070446.1">
        <property type="protein sequence ID" value="ENSMICP00000049704.1"/>
        <property type="gene ID" value="ENSMICG00000005055.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875809"/>
    <dbReference type="KEGG" id="mmur:105875809"/>
    <dbReference type="CTD" id="9587"/>
    <dbReference type="GeneTree" id="ENSGT00390000003812"/>
    <dbReference type="OrthoDB" id="6334764at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.20:FF:000001">
        <property type="entry name" value="MAD2L1 binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009511">
        <property type="entry name" value="MAD1/Cdc20-bound-Mad2-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053729">
        <property type="entry name" value="MAD2L1BP_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15681:SF1">
        <property type="entry name" value="MAD2L1-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06581">
        <property type="entry name" value="p31comet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="272" mass="30780" checksum="A082D71288CE605A" modified="2022-01-19" version="1">MAAPEPEVLSPAAVPDLEWYEKSEETDAPQIELLETTSTQEPPNPSEPFCPRDCMVPVVFPGPVSQEGCCRFTCELLKHIMYQRQQLPLPYEQLKHFYRKASPQAEEVVRKKPRAEVSSRKCQQALAELESVLSHLEGFFARTLVPRVLILLGGSALCPKEFYELDLSRLAPNSVDQSLSTAACLRRLFRAIFMADAFSELQAPPLMGTIVMAQGHRDCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPSIQSTAWEDYIWFQAPVTLRGFHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H8Q7</accession>
    <name>A0A8B7H8Q7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Engulfment and cell motility 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ELMO1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015728">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633031.1">
        <property type="nucleotide sequence ID" value="XM_012777577.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H8Q7"/>
    <dbReference type="Ensembl" id="ENSMICT00000009000.3">
        <property type="protein sequence ID" value="ENSMICP00000008199.2"/>
        <property type="gene ID" value="ENSMICG00000008990.3"/>
    </dbReference>
    <dbReference type="CTD" id="9844"/>
    <dbReference type="GeneTree" id="ENSGT00940000155994"/>
    <dbReference type="OrthoDB" id="9514336at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032045">
        <property type="term" value="C:guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="project" value="Ensembl"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HEU4</accession>
    <name>A0A8B7HEU4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">KLF transcription factor 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KLF11</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012103">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634428.1">
        <property type="nucleotide sequence ID" value="XM_012778974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HEU4"/>
    <dbReference type="Ensembl" id="ENSMICT00000063717.1">
        <property type="protein sequence ID" value="ENSMICP00000047880.1"/>
        <property type="gene ID" value="ENSMICG00000012761.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879023"/>
    <dbReference type="KEGG" id="mmur:105879023"/>
    <dbReference type="CTD" id="8462"/>
    <dbReference type="GeneTree" id="ENSGT00940000155982"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21584">
        <property type="entry name" value="KLF11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000134">
        <property type="entry name" value="Krueppel-like factor 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000018">
        <property type="entry name" value="Krueppel-like factor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000205">
        <property type="entry name" value="Putative Krueppel-like factor 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF65">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="401"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="519" mass="55571" checksum="8A8FAADFEC7D9D1C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HP03</accession>
    <name>A0A8B7HP03_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="35">Diacylglycerol kinase</fullName>
            <shortName evidence="35">DAG kinase</shortName>
            <ecNumber evidence="35">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="40" type="primary">DGKQ</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="40" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="40" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-O-alkyl-2-acyl-sn-glycerol + ATP = 1-O-alkyl-2-acyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52595"/>
            <dbReference type="ChEBI" id="CHEBI:73332"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:44073"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-O-hexadecyl-2-acetyl-sn-glycerol + ATP = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75936"/>
            <dbReference type="ChEBI" id="CHEBI:78385"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:41677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-O-hexadecyl-sn-glycerol + ATP = 1-O-hexadecyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41672"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:34115"/>
            <dbReference type="ChEBI" id="CHEBI:77580"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:41673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + ATP = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40323"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:75728"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:40324"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15850"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58014"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.93"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:16938"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="33">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="34">Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ. Interacts with PRKCE. Interacts with PRKCH. Interacts with PLCB1. Interacts with NR5A1; the interaction requires both LXXLL motifs in DGKQ and is required for full phosphatidic acid-mediated activation of NR5A1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="27">Synapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 35">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012783405.2"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSMICP00000027039.2"/>
        <property type="gene ID" value="ENSMICG00000012917.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881658"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159492"/>
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        <property type="component" value="Chromosome 18"/>
    </dbReference>
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        <property type="term" value="C:cytoskeleton"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:endosome"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:vesicle membrane"/>
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    </dbReference>
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        <property type="term" value="F:alkylglycerol kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
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    <dbReference type="GO" id="GO:0043274">
        <property type="term" value="F:phospholipase binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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    </dbReference>
    <dbReference type="GO" id="GO:1903413">
        <property type="term" value="P:cellular response to bile acid"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046339">
        <property type="term" value="P:diacylglycerol metabolic process"/>
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    </dbReference>
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        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
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        <property type="term" value="P:lipid phosphorylation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of gene expression"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0010628">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090037">
        <property type="term" value="P:positive regulation of protein kinase C signaling"/>
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        <property type="term" value="P:regulation of cholesterol metabolic process"/>
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    </dbReference>
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        <property type="term" value="P:regulation of cortisol biosynthetic process"/>
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        <property type="term" value="P:regulation of gluconeogenesis"/>
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        <property type="term" value="P:regulation of progesterone biosynthetic process"/>
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    </dbReference>
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        <property type="term" value="P:regulation of synaptic vesicle endocytosis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of TORC1 signaling"/>
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    <dbReference type="GO" id="GO:0006357">
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        <property type="term" value="P:response to cAMP"/>
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        <property type="term" value="P:thrombin-activated receptor signaling pathway"/>
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    </dbReference>
    <dbReference type="CDD" id="cd20803">
        <property type="entry name" value="C1_DGKtheta_typeV_rpt1"/>
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    </dbReference>
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        <property type="entry name" value="C1_DGKtheta_typeV_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1_DGKtheta_typeV_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RA1_DAGK-theta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RA2_DAGK-theta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000188">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
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    <dbReference type="FunFam" id="3.40.50.10330:FF:000012">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
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        <property type="entry name" value="DGKtheta_RBD"/>
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        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
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    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
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        <property type="entry name" value="PKC_DAG/PE"/>
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        <property type="entry name" value="RA_dom"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RBD_DGKtheta"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAGPEDOMAIN"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="3"/>
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    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="18 35" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="22" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="16 35" id="KW-0418">Kinase</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 35" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="41" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0770">Synapse</keyword>
    <keyword evidence="11 35" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="37">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
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    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="37">
        <location>
            <begin position="117"/>
            <end position="164"/>
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    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="37">
        <location>
            <begin position="179"/>
            <end position="230"/>
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    </feature>
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        <location>
            <begin position="396"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="38">
        <location>
            <begin position="585"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="1"/>
            <end position="57"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="268"/>
            <end position="295"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="36">
        <location>
            <begin position="916"/>
            <end position="943"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="36">
        <location>
            <begin position="36"/>
            <end position="56"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="36">
        <location>
            <begin position="916"/>
            <end position="925"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00034614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00034642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00034647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00049500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00059432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00065933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="37">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="38">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="39">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027039.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="943" mass="102116" checksum="B4FCB606D029A355" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HXA2</accession>
    <name>A0A8B7HXA2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Max dimerization protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Max-associated protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MXD3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with SIN3A AND SIN3B. Interacts with RNF17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03033444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642783.1">
        <property type="nucleotide sequence ID" value="XM_012787329.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HXA2"/>
    <dbReference type="Ensembl" id="ENSMICT00000069523.1">
        <property type="protein sequence ID" value="ENSMICP00000049150.1"/>
        <property type="gene ID" value="ENSMICG00000043849.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105883851"/>
    <dbReference type="KEGG" id="mmur:105883851"/>
    <dbReference type="CTD" id="83463"/>
    <dbReference type="GeneTree" id="ENSGT00940000161050"/>
    <dbReference type="OrthoDB" id="5920083at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18932">
        <property type="entry name" value="bHLHzip_Mad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000073">
        <property type="entry name" value="MAX dimerization protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969:SF6">
        <property type="entry name" value="MAX DIMERIZATION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11969">
        <property type="entry name" value="MAX DIMERIZATION, MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="13">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="63"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="206" mass="23330" checksum="1BDCD84C5BA00948" modified="2022-01-19" version="1">MEPVATSIQVLLQAAEFLERREREAEHGYASLCPHRSPGPAHRRRTHPPQAAGALDSGRSVHNELEKRRRAQLKRCLERLKQQMPLGADCARYTTLSLLRRARTHIQKLEEQEQRARQLKEQLRGEQRSLQRQLEQLRGLAAPGERERLRADSLDSSGLSSERSDSDQEELEVDVESLVFAGDAELLRGFGAGREHSYSHGAGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HZ53</accession>
    <name>A0A8B7HZ53_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PFN4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in male fertility. Required for manchette development and acrosome biogenesis during spermiogenesis. Binds in vitro to phospholipids, including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidic acid (PA). Contrary to other profilin family members, does not bind to actin in vitro.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011923">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643548.1">
        <property type="nucleotide sequence ID" value="XM_012788094.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643549.1">
        <property type="nucleotide sequence ID" value="XM_012788095.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HZ53"/>
    <dbReference type="Ensembl" id="ENSMICT00000001540.3">
        <property type="protein sequence ID" value="ENSMICP00000001400.2"/>
        <property type="gene ID" value="ENSMICG00000001541.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884341"/>
    <dbReference type="KEGG" id="mmur:105884341"/>
    <dbReference type="CTD" id="375189"/>
    <dbReference type="GeneTree" id="ENSGT00390000017067"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001675">
        <property type="term" value="P:acrosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905198">
        <property type="term" value="P:manchette assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120316">
        <property type="term" value="P:sperm flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000007">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11604:SF2">
        <property type="entry name" value="PROFILIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0744">Spermatogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001400.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="129" mass="14601" checksum="E9F10AAE239340E4" modified="2022-01-19" version="1">MSHLQNLLLDTLLGTKHVDSAALIKLHEWSLCVASPGFSVMPSDVRRLVNGFAKNPLQARREGLYFKEKDYKCVRADEYSLYAKNENTGVIVVKTHQYLLVTTYTEGMYPSVCVEATEKLGDYLRKKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HZW5</accession>
    <name>A0A8B7HZW5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Spastin</fullName>
            <ecNumber evidence="16">5.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16 22" type="primary">SPAST</name>
        <name evidence="16" type="synonym">SPG4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.</text>
            <dbReference type="EC" id="5.6.1.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Midbody</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Cytoskeleton</location>
            <location evidence="16">Microtubule organizing center</location>
            <location evidence="16">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
            <location evidence="16">Cytoskeleton</location>
            <location evidence="16">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="16">Forms an intramembrane hairpin-like structure in the membrane. Localization to the centrosome is independent of microtubules. Localizes to the midbody of dividing cells, and this requires CHMP1B. Enriched in the distal axons and branches of postmitotic neurons. Localizes to endoplasmic reticulum tubular network.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the AAA ATPase family. Spastin subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.1" evidence="16"/>
    <dbReference type="EMBL" id="ABDC03011894">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643831.1">
        <property type="nucleotide sequence ID" value="XM_012788377.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HZW5"/>
    <dbReference type="Ensembl" id="ENSMICT00000015584.3">
        <property type="protein sequence ID" value="ENSMICP00000014202.2"/>
        <property type="gene ID" value="ENSMICG00000015575.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884471"/>
    <dbReference type="KEGG" id="mmur:105884471"/>
    <dbReference type="CTD" id="6683"/>
    <dbReference type="GeneTree" id="ENSGT00940000156258"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008568">
        <property type="term" value="F:microtubule severing ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008089">
        <property type="term" value="P:anterograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019896">
        <property type="term" value="P:axonal transport of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032506">
        <property type="term" value="P:cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010458">
        <property type="term" value="P:exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090148">
        <property type="term" value="P:membrane fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051013">
        <property type="term" value="P:microtubule severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
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    <dbReference type="GO" id="GO:0034214">
        <property type="term" value="P:protein hexamerization"/>
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        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
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        <location>
            <begin position="1"/>
            <end position="56"/>
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        <location>
            <begin position="116"/>
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            <begin position="374"/>
            <end position="510"/>
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            <begin position="1"/>
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            <begin position="222"/>
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        <location>
            <begin position="4"/>
            <end position="11"/>
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            <begin position="59"/>
            <end position="67"/>
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            <begin position="309"/>
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            <begin position="18"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="616" mass="67524" checksum="30D35F40FA3DB812" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WRK9</accession>
    <name>A0A8B7WRK9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SKI family transcriptional corepressor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SKOR2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKI family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012745375.1"/>
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        <property type="nucleotide sequence ID" value="XM_020282355.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000033995.1"/>
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        <property type="component" value="Chromosome 19"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:transcription regulator complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:histone deacetylase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030514">
        <property type="term" value="P:negative regulation of BMP signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of cerebellar granule cell precursor proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of dendrite morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of neuroblast proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:smoothened signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21080">
        <property type="entry name" value="DHD_Skor"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SKI family transcriptional corepressor 1 homolog-B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.390.10">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.20">
        <property type="entry name" value="Ski"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014890">
        <property type="entry name" value="c-SKI_SMAD4-bd_dom"/>
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    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010919">
        <property type="entry name" value="SAND-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003380">
        <property type="entry name" value="SKI/SNO/DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037000">
        <property type="entry name" value="Ski_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023216">
        <property type="entry name" value="Tscrpt_reg_SKI_SnoN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005:SF7">
        <property type="entry name" value="SKI FAMILY TRANSCRIPTIONAL COREPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10005">
        <property type="entry name" value="SKI ONCOGENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08782">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02437">
        <property type="entry name" value="Ski_Sno_DHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01046">
        <property type="entry name" value="c-SKI_SMAD_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63763">
        <property type="entry name" value="SAND domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="c-SKI SMAD4-binding" evidence="8">
        <location>
            <begin position="144"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="510"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="567"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="749"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="858"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="882"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="909"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1012" mass="105605" checksum="F542E418347878E3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X0X1</accession>
    <name>A0A8B7X0X1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial S-adenosylmethionine carrier protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Solute carrier family 25 member 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLC25A26</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-adenosyl-L-homocysteine(out) + S-adenosyl-L-methionine(in) = S-adenosyl-L-homocysteine(in) + S-adenosyl-L-methionine(out)</text>
            <dbReference type="Rhea" id="RHEA:75479"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_020140948.1">
        <property type="nucleotide sequence ID" value="XM_020285359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X0X1"/>
    <dbReference type="Ensembl" id="ENSMICT00000012808.3">
        <property type="protein sequence ID" value="ENSMICP00000011668.3"/>
        <property type="gene ID" value="ENSMICG00000012813.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105862327"/>
    <dbReference type="CTD" id="115286"/>
    <dbReference type="GeneTree" id="ENSGT00550000074950"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180003">
        <property type="term" value="F:S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990543">
        <property type="term" value="P:mitochondrial S-adenosyl-L-methionine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000199">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="91"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011668.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="188" mass="19848" checksum="2D5F6C58B50B1557" modified="2022-01-19" version="1">MPGKHMLAASGGEVVACLIRVPSEVVKQRAQVSASSRTFQIFSNILYEEGIRGLYRGYKSTVLREIPFSLVQFPLWESLKALWSCRQGRAAESWQSAVCGALAGGFAAAVTTPLDVAKTRIMLAKAGSSSASGNVLSALHGVWRSQGLTGLFAGVVPRVAAISLGGFIFLGAYDKTRSFLLGVGAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XE95</accession>
    <name>A0A8B7XE95_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Acetyl-coenzyme A thioesterase</fullName>
            <ecNumber evidence="5">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Acyl-CoA thioester hydrolase 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Acyl-coenzyme A thioesterase 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cytoplasmic acetyl-CoA hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ACOT12</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:20290"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>butanoyl-CoA + H2O = butanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40111"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:40112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hexanoyl-CoA + H2O = hexanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17120"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:40116"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03016756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145719.1">
        <property type="nucleotide sequence ID" value="XM_020290130.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XE95"/>
    <dbReference type="Ensembl" id="ENSMICT00000063124.1">
        <property type="protein sequence ID" value="ENSMICP00000048248.1"/>
        <property type="gene ID" value="ENSMICG00000047986.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882202"/>
    <dbReference type="KEGG" id="mmur:105882202"/>
    <dbReference type="CTD" id="134526"/>
    <dbReference type="GeneTree" id="ENSGT00940000160328"/>
    <dbReference type="OrthoDB" id="3184331at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08914">
        <property type="entry name" value="START_STARD15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000029">
        <property type="entry name" value="Acyl-CoA thioesterase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000023">
        <property type="entry name" value="Acyl-CoA thioesterase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000011">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049:SF3">
        <property type="entry name" value="ACETYL-COENZYME A THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="ACYL COENZYME A THIOESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="21">
        <location>
            <begin position="5"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="21">
        <location>
            <begin position="179"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="20">
        <location>
            <begin position="365"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011774"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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            <dbReference type="ARBA" id="ARBA00052880"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00060138"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
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        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS51770"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048248.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="555" mass="62123" checksum="CB01B8FB1869AE39" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UHW1</accession>
    <name>A0A8C5UHW1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ess-2 splicing factor homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ESS2</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESS2 family.</text>
    </comment>
    <dbReference type="RefSeq" id="XP_012632085.1">
        <property type="nucleotide sequence ID" value="XM_012776631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UHW1"/>
    <dbReference type="Ensembl" id="ENSMICT00000000069.3">
        <property type="protein sequence ID" value="ENSMICP00000000064.2"/>
        <property type="gene ID" value="ENSMICG00000000068.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877754"/>
    <dbReference type="KEGG" id="mmur:105877754"/>
    <dbReference type="CTD" id="8220"/>
    <dbReference type="GeneTree" id="ENSGT00390000009387"/>
    <dbReference type="OrthoDB" id="19679at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940">
        <property type="entry name" value="ES-2 PROTEIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12940:SF0">
        <property type="entry name" value="SPLICING FACTOR ESS-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000064.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="476" mass="52662" checksum="E8A0A11E3701122D" modified="2022-01-19" version="1">METPGASDPSRLLPAGSGPRRKRATGEAGAATSKQRVLDEEEYIEGLQTVIQRDFFPDVEKLQAQKEYLEAEENGDLERMRQIAIKFGSALGKMSREPLPPYVTPATFETPEVHTGTGVVGSKPRPRGRGLEDGEAGEEEKKELLPNLDIFLSRYTSEDNASFQEIMEVAKEKSRARHAWLYQAEEEFEKRQKDNLELPSAEHQAIESSQAGVETWKYKAKNSLMYYPEGVPEEQQLFKKPRQVVHKNTRFLRDPFSQALSRCQLQQAAALNAQHKQGKVGPDGKELIPQESPRVGGFGFVATPSPAPGVNESPLMTWGEVENTPLRVEGSETPYVDRTPGPAFKILEPGRRERLGLKMANEAAAKNRAKKQEALRRVTENLASLTPKGLSPAMSPALQRLVSRTASKYTDRALRASYTPSPTRLTHLKTPASGLQTPTSTPIPASAARTPLTLDPASITDNLLQLPARRKASDFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UKZ4</accession>
    <name>A0A8C5UKZ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UDP-glucuronosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC105864508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132367"/>
            <dbReference type="ChEBI" id="CHEBI:132368"/>
            <dbReference type="EC" id="2.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.17" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03029057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UKZ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000001208.3">
        <property type="protein sequence ID" value="ENSMICP00000001101.3"/>
        <property type="gene ID" value="ENSMICG00000001210.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162432"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000001">
        <property type="entry name" value="UDP-glucuronosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050271">
        <property type="entry name" value="UDP-glycosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043">
        <property type="entry name" value="EG:EG0003.4 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48043:SF140">
        <property type="entry name" value="UDP-GLUCURONOSYLTRANSFERASE 2A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
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    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001101.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="288" mass="32759" checksum="7E001D3FF08CD90E" modified="2022-01-19" version="1">RPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQSSEEHGVVVFSLGSMVKNLTEEKANIIALALAQIPQKVLWRYGGKKPATLGNNTRLYDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGVPMFVDQPDNIAHMKAKGAAMEVNLNTMTSADLLNALRTVINEPSYKENAMRLSRIHHDQPMKPLDRAVFWIEFVMRHKGAKHLRPAAHNLTWIQYHSLDVIGFLLACVATCIILVMKCCLFSCQKFGKTKRKKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UL26</accession>
    <name>A0A8C5UL26_MICMU</name>
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        <submittedName>
            <fullName evidence="1">Chromosome 16 open reading frame 78</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">C16orf78</name>
        <name evidence="1" type="synonym">C20H16orf78</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029171">
        <property type="entry name" value="DUF4638"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35679">
        <property type="entry name" value="RIKEN CDNA 4933402J07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35679:SF1">
        <property type="entry name" value="RIKEN CDNA 4933402J07 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15472">
        <property type="entry name" value="DUF4638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000779.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="258" mass="30142" checksum="5FB294D628A9B8CB" modified="2022-01-19" version="1">MAEQPEDLKDLMPTERKSMWRTAEERRMSDLTRVLEWLERRKGKKKQVFQVRTVKEDEKKEEKKVKGILKKHGRNQAETTDASWQSSNKEGDPIIYRKVYGLEQKAKRHSIISGNYSRDIPRKSDLDIKDVIALESLQRPTSFRRQSVAIDPSLQDSLYGTRRVPFSREWSSKTSDSLYERKLKSLLEKGTEPKIETAKMLKPEEVLSCRYLRLSKNNIRTLLKLCRDAGMNVDIHPHMVESEIDAKKVFSRIHSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UMV0</accession>
    <name>A0A8C5UMV0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM79</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003186">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UMV0"/>
    <dbReference type="Ensembl" id="ENSMICT00000002259.3">
        <property type="protein sequence ID" value="ENSMICP00000002067.3"/>
        <property type="gene ID" value="ENSMICG00000002260.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002390"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070268">
        <property type="term" value="P:cornification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042335">
        <property type="term" value="P:cuticle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002070">
        <property type="term" value="P:epithelial cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031069">
        <property type="term" value="P:hair follicle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045684">
        <property type="term" value="P:positive regulation of epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31004:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 79"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002067.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="322" mass="35100" checksum="3D4E1123E82FA0CE" modified="2022-01-19" version="1">MTEPESLALQEVKGSEVPEKSPPEALVPNGRQPEGEGGGESPGAESLRMESSAGSPTAIEGAEDGLDSTVSEAATLPWGTGPQPSAPFLDPPGWRNIEPEPLKSEPTTKLEELPEDDANLLPEKVARAFVPIDLQCIERRPQEDLIVCCEASEGERRTFLPTRVTHPEPPECKWAEAVVRPPGRSCGGCGSCGGREGLRAVASVGAALVLFPCLLYGAYAFLPFDAPRLPTMSSRLVYTLRCGVFATFPIILLIYWLTFAVGRSFRGFGYGLTFLPLLSMLVWNLYYMFVVEPERMLTAAESRLDYPDHARSASDYRPRPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQM7</accession>
    <name>A0A8C5UQM7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="23">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">PLCE1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell projection</location>
            <location evidence="5">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="23"/>
    <dbReference type="EMBL" id="ABDC03019321">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621748.1">
        <property type="nucleotide sequence ID" value="XM_012766294.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000005553.3">
        <property type="protein sequence ID" value="ENSMICP00000005065.3"/>
        <property type="gene ID" value="ENSMICG00000005545.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872349"/>
    <dbReference type="CTD" id="51196"/>
    <dbReference type="GeneTree" id="ENSGT00940000157356"/>
    <dbReference type="OrthoDB" id="10068636at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006651">
        <property type="term" value="P:diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032835">
        <property type="term" value="P:glomerulus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046488">
        <property type="term" value="P:phosphatidylinositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010592">
        <property type="term" value="P:positive regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16203">
        <property type="entry name" value="EFh_PI-PLCepsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08596">
        <property type="entry name" value="PI-PLCc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17229">
        <property type="entry name" value="RA1_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01780">
        <property type="entry name" value="RA2_PLC-epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000092">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000085">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000086">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000118">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000090">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046973">
        <property type="entry name" value="PLC-epsilon1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028398">
        <property type="entry name" value="PLC-epsilon1_RA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015359">
        <property type="entry name" value="PLC_EF-hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046974">
        <property type="entry name" value="PLC_epsilon1_EF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF6">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09279">
        <property type="entry name" value="EF-hand_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 22" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="13 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 23" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="17 23" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="19" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Ras-GEF" evidence="27">
        <location>
            <begin position="530"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="26">
        <location>
            <begin position="1754"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="25">
        <location>
            <begin position="1850"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="28">
        <location>
            <begin position="2134"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1051"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1565"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1682"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="2259"/>
            <end position="2301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1164"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1578"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1711"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2261"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="2290"/>
            <end position="2301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00059831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005065.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2301" mass="257798" checksum="BEEBE4661FF2F7CE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQX9</accession>
    <name>A0A8C5UQX9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copine-5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Copine V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CPNE5</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Perikaryon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007445">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602363.1">
        <property type="nucleotide sequence ID" value="XM_012746909.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQX9"/>
    <dbReference type="Ensembl" id="ENSMICT00000004696.3">
        <property type="protein sequence ID" value="ENSMICP00000004279.3"/>
        <property type="gene ID" value="ENSMICG00000004691.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861431"/>
    <dbReference type="CTD" id="57699"/>
    <dbReference type="GeneTree" id="ENSGT00940000156194"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043204">
        <property type="term" value="C:perikaryon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000117">
        <property type="entry name" value="copine-5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000013">
        <property type="entry name" value="copine-9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037768">
        <property type="entry name" value="C2B_Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045052">
        <property type="entry name" value="Copine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010734">
        <property type="entry name" value="Copine_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857">
        <property type="entry name" value="COPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10857:SF51">
        <property type="entry name" value="COPINE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="161"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="15">
        <location>
            <begin position="328"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="562"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00076303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004279.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="593" mass="65667" checksum="976E9C4AA2EC2968" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5US52</accession>
    <name>A0A8C5US52_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Adenylate kinase isoenzyme 1</fullName>
            <shortName evidence="25">AK 1</shortName>
            <ecNumber evidence="25">2.7.4.3</ecNumber>
            <ecNumber evidence="25">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">ATP-AMP transphosphorylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Adenylate monophosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Myokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25 27" type="primary">AK1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Also catalyzes at a very low rate the synthesis of thiamine triphosphate (ThTP) from thiamine diphosphate (ThDP) and ADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>CDP + GTP = CTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79859"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>GDP + ATP = GTP + ADP</text>
            <dbReference type="Rhea" id="RHEA:27686"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>GTP + UDP = UTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79863"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>UDP + ATP = UTP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25098"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a ribonucleoside 5'-phosphate + ATP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:24036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dADP + GTP = dATP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79871"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>dAMP + ATP = dADP + ADP</text>
            <dbReference type="Rhea" id="RHEA:23100"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>dAMP + dATP = 2 dADP</text>
            <dbReference type="Rhea" id="RHEA:78311"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:58245"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dATP + AMP = dADP + ADP</text>
            <dbReference type="Rhea" id="RHEA:79899"/>
            <dbReference type="ChEBI" id="CHEBI:57667"/>
            <dbReference type="ChEBI" id="CHEBI:61404"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dCDP + GTP = dCTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79875"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dGDP + ATP = dGTP + ADP</text>
            <dbReference type="Rhea" id="RHEA:27690"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58595"/>
            <dbReference type="ChEBI" id="CHEBI:61429"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>dTDP + GTP = dTTP + GDP</text>
            <dbReference type="Rhea" id="RHEA:79867"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>thiamine diphosphate + ADP = thiamine triphosphate + AMP</text>
            <dbReference type="Rhea" id="RHEA:69180"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:58938"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 25">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 25">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="25">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the adenylate kinase family. AK1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="25"/>
    <dbReference type="EC" id="2.7.4.6" evidence="25"/>
    <dbReference type="EMBL" id="ABDC03014907">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627493.1">
        <property type="nucleotide sequence ID" value="XM_012772039.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627494.1">
        <property type="nucleotide sequence ID" value="XM_012772040.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627495.1">
        <property type="nucleotide sequence ID" value="XM_012772041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5US52"/>
    <dbReference type="Ensembl" id="ENSMICT00000005693.3">
        <property type="protein sequence ID" value="ENSMICP00000005193.3"/>
        <property type="gene ID" value="ENSMICG00000005696.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875233"/>
    <dbReference type="CTD" id="203"/>
    <dbReference type="GeneTree" id="ENSGT00940000158325"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015949">
        <property type="term" value="P:nucleobase-containing small molecule interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009142">
        <property type="term" value="P:nucleoside triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03171">
        <property type="entry name" value="Adenylate_kinase_AK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028582">
        <property type="entry name" value="AK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006267">
        <property type="entry name" value="AK1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01360">
        <property type="entry name" value="aden_kin_iso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 25" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 25 26" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 25 26" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="25">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="25">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N-acetylmethionine" evidence="25">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005193.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="194" mass="21594" checksum="69999BA8925A9711" modified="2022-01-19" version="1">MEEKLKKSKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSARGKKLSEIMEKGQLVPLETVLDMLRDAMVANAETSKGFLIDGYPREVQQGEEFERRIGQPTLLLYVDAGPETMTMRLLKRGENSGRVDDNEETIKKRLETYYQATEPVIAFYEKRGIVRKVNAEGSVDSVFSQVCTHLDALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5US83</accession>
    <name>A0A8C5US83_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase 4A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PTP4A3</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03013501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5US83"/>
    <dbReference type="Ensembl" id="ENSMICT00000006854.3">
        <property type="protein sequence ID" value="ENSMICP00000006246.2"/>
        <property type="gene ID" value="ENSMICG00000030190.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159581"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000188">
        <property type="entry name" value="Protein tyrosine phosphatase type IVA 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006246.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="148" mass="16754" checksum="323F776C4C0A3B90" modified="2022-01-19" version="1">MARMNRPAPVEVSYKNMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKAPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLLKAKFCEDPGSCVAVHCVAGLGRKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTKCCVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UT78</accession>
    <name>A0A8C5UT78_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Thioredoxin domain-containing protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">3'-5' exonuclease NME8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NME/NM23 family member 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Spermatid-specific thioredoxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">NME8</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. In vitro, it has neither nucleoside diphosphate kinase (NDPK) activity nor reducing activity on disulfide bonds. Exhibits a 3'-5' exonuclease activity with a preference for single-stranded DNA, suggesting roles in DNA proofreading and repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the NDK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015729">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015730">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UT78"/>
    <dbReference type="Ensembl" id="ENSMICT00000001940.3">
        <property type="protein sequence ID" value="ENSMICP00000001771.3"/>
        <property type="gene ID" value="ENSMICG00000001938.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161182"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036157">
        <property type="term" value="C:outer dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097598">
        <property type="term" value="C:sperm cytoplasmic droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097225">
        <property type="term" value="C:sperm midpiece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04416">
        <property type="entry name" value="NDPk_TX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02948">
        <property type="entry name" value="TRX_NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000012">
        <property type="entry name" value="Thioredoxin domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051766">
        <property type="entry name" value="TXND_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46135">
        <property type="entry name" value="NME/NM23 FAMILY MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46135:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="3"/>
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    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Thioredoxin" evidence="18">
        <location>
            <begin position="1"/>
            <end position="119"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="235"/>
            <end position="265"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058364"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060743"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068138"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00080016"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00080209"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001771.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="589" mass="66977" checksum="F6BC3841762D501F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTB0</accession>
    <name>A0A8C5UTB0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Cholinergic receptor nicotinic alpha 2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CHRNA2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023689">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138261.1">
        <property type="nucleotide sequence ID" value="XM_020282672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UTB0"/>
    <dbReference type="Ensembl" id="ENSMICT00000007696.3">
        <property type="protein sequence ID" value="ENSMICP00000007002.3"/>
        <property type="gene ID" value="ENSMICG00000007702.3"/>
    </dbReference>
    <dbReference type="CTD" id="1135"/>
    <dbReference type="GeneTree" id="ENSGT00940000158299"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098878">
        <property type="term" value="C:neurotransmitter receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015464">
        <property type="term" value="F:acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="LGIC_ECD_nAChR_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000014">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000005">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor alpha4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039441" evidence="18">
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            <begin position="27"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="297"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
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            <begin position="331"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="59"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="272"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="25"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
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    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF02931"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007002.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="530" mass="59360" checksum="9A8F181EA49C00C5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTC3</accession>
    <name>A0A8C5UTC3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Interleukin-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IL6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of a hexamer of two molecules each of IL6, IL6R and IL6ST; first binds to IL6R to associate with the signaling subunit IL6ST. Interacts with IL6R (via the N-terminal ectodomain); this interaction may be affected by IL6R-binding with SORL1, hence decreasing IL6 cis signaling. Interacts with SORL1 (via the N-terminal ectodomain); this interaction leads to IL6 internalization and lysosomal degradation. May form a trimeric complex with the soluble SORL1 ectodomain and soluble IL6R receptor; this interaction might stabilize circulating IL6, hence promoting IL6 trans signaling.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IL-6 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UTC3"/>
    <dbReference type="Ensembl" id="ENSMICT00000006697.3">
        <property type="protein sequence ID" value="ENSMICP00000006110.2"/>
        <property type="gene ID" value="ENSMICG00000006701.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000878"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005896">
        <property type="term" value="C:interleukin-6 receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005138">
        <property type="term" value="F:interleukin-6 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046427">
        <property type="term" value="P:positive regulation of receptor signaling pathway via JAK-STAT"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003574">
        <property type="entry name" value="IL-6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030474">
        <property type="entry name" value="IL-6/GCSF/MGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48494">
        <property type="entry name" value="INTERLEUKIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48494:SF1">
        <property type="entry name" value="INTERLEUKIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00489">
        <property type="entry name" value="IL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001935">
        <property type="entry name" value="IL6_MGF_GCSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00433">
        <property type="entry name" value="IL6GCSFMGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00434">
        <property type="entry name" value="INTERLEUKIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00126">
        <property type="entry name" value="IL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0011">Acute phase</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034675499" description="Interleukin-6" evidence="7">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="67"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001935-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006110.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="211" mass="23323" checksum="5012061BE20242C4" modified="2022-01-19" version="1">MKSLSARAFSLGLLLVVATAFPTPEPLEEAAKDDATPDKPSLTTPEQTEGLMKHLMSKIDQLTEQLCGDSSKCGDAKEALTENNLKLPQITEQDGCFQSGFSEDSCLETITSGLAAYHVYIEYIEDKFEGDLNSARALDMGVKYLIDILKEKIKNAEAVTTPSPTANAKLIEDLESQDEWVQHTAINIILRSLKEYLQFSLRAIRSHRADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UUG8</accession>
    <name>A0A8C5UUG8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Junctional cadherin 5 associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">JCAD</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03028313">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028315">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UUG8"/>
    <dbReference type="Ensembl" id="ENSMICT00000006772.3">
        <property type="protein sequence ID" value="ENSMICP00000006174.3"/>
        <property type="gene ID" value="ENSMICG00000006774.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015348"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903589">
        <property type="term" value="P:positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900748">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028221">
        <property type="entry name" value="JCAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34757:SF1">
        <property type="entry name" value="JUNCTIONAL CADHERIN 5-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34757">
        <property type="entry name" value="JUNCTIONAL PROTEIN ASSOCIATED WITH CORONARY ARTERY DISEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15351">
        <property type="entry name" value="JCAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1102"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006174.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1259" mass="134228" checksum="1CC02E18983B9E67" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXE5</accession>
    <name>A0A8C5UXE5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Corin, serine peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CORIN</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the peptidase S1 family. CLIP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03032515">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032517">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032520">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032521">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032522">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032523">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXE5"/>
    <dbReference type="Ensembl" id="ENSMICT00000010495.3">
        <property type="protein sequence ID" value="ENSMICP00000009560.3"/>
        <property type="gene ID" value="ENSMICG00000010493.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157103"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007565">
        <property type="term" value="P:female pregnancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016486">
        <property type="term" value="P:peptide hormone processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003050">
        <property type="term" value="P:regulation of systemic arterial blood pressure by atrial natriuretic peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07445">
        <property type="entry name" value="CRD_corin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07888">
        <property type="entry name" value="CRD_corin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000013">
        <property type="entry name" value="atrial natriuretic peptide-converting enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000011">
        <property type="entry name" value="Corin, serine peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000024">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000002">
        <property type="entry name" value="Transmembrane protease serine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017052">
        <property type="entry name" value="Corin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041762">
        <property type="entry name" value="Corin_CRD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041763">
        <property type="entry name" value="Corin_CRD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252">
        <property type="entry name" value="ACROSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24252:SF11">
        <property type="entry name" value="ATRIAL NATRIURETIC PEPTIDE-CONVERTING ENZYME ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15494">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036376">
        <property type="entry name" value="Corin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00261">
        <property type="entry name" value="LDLRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01209">
        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50068">
        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="129"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="21">
        <location>
            <begin position="370"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="23">
        <location>
            <begin position="574"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="22">
        <location>
            <begin position="686"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="449"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="558"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009560.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="898" mass="98916" checksum="C3C3816C88BBA8F2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V065</accession>
    <name>A0A8C5V065_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Immunoglobulin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026623">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V065"/>
    <dbReference type="Ensembl" id="ENSMICT00000012325.3">
        <property type="protein sequence ID" value="ENSMICP00000011221.3"/>
        <property type="gene ID" value="ENSMICG00000010017.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263478"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032396">
        <property type="term" value="F:inhibitory MHC class I receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002764">
        <property type="term" value="P:immune response-regulating signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000049">
        <property type="entry name" value="Leukocyte immunoglobulin-like receptor subfamily B member 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050412">
        <property type="entry name" value="Ig-like_Receptors_ImmuneReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738:SF179">
        <property type="entry name" value="LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11738">
        <property type="entry name" value="MHC CLASS I NK CELL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="12">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="12">
        <location>
            <begin position="106"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011221.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="252" mass="28218" checksum="6E29F578A1DCC7FB" modified="2022-01-19" version="1">PFPWTLVSHPSSDSVLTWGSPVTMWCQGTLGAKEYRLDKEKFSEPWDTQTPLEPVNKVKFNIPSMTEHYAGRYHCYYYSSDGWSESSDPLELVVTGLYGKATLSALPSPVVTPGGNLTIQCVSQEGFDSFILVEKGQKLSWTGDPQRTSSGQFQALFPVGPVTPSHRWTFRCYGCYRNNPQVWSQPSDPLELLVSGAPESMSPTHKNAPHPQDYTVENLVRMGLAGLILVALGILLFRDWRSRRRYQDAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9F7</accession>
    <name>A0A8C5V9F7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mediator of RNA polymerase II transcription subunit 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED23</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008416">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000036368.2">
        <property type="protein sequence ID" value="ENSMICP00000018000.2"/>
        <property type="gene ID" value="ENSMICG00000002926.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010380"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000409">
        <property type="term" value="P:positive regulation of T cell extravasation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021629">
        <property type="entry name" value="Mediator_Med23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12691:SF10">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11573">
        <property type="entry name" value="Med23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1349"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1352"/>
            <end position="1373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010222"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018000.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAA7</accession>
    <name>A0A8C5VAA7_MICMU</name>
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        <recommendedName>
            <fullName evidence="6">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VAA7"/>
    <dbReference type="Ensembl" id="ENSMICT00000041183.2">
        <property type="protein sequence ID" value="ENSMICP00000018311.1"/>
        <property type="gene ID" value="ENSMICG00000034194.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163741"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000669">
        <property type="entry name" value="Eyes shut homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051022">
        <property type="entry name" value="Notch_Cell-Fate_Det"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24049">
        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 4" id="KW-0245">EGF-like domain</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034148034" description="EGF-like domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="171"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="294"/>
            <end position="330"/>
        </location>
    </feature>
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            <end position="368"/>
        </location>
    </feature>
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            <end position="201"/>
        </location>
    </feature>
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    </feature>
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        </location>
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    </feature>
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        <location>
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            <end position="329"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018311.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VC01</accession>
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        <submittedName>
            <fullName evidence="10">Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CITED1</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CITED family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VC01"/>
    <dbReference type="Ensembl" id="ENSMICT00000016604.3">
        <property type="protein sequence ID" value="ENSMICP00000015130.3"/>
        <property type="gene ID" value="ENSMICG00000016613.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063624"/>
    <dbReference type="Proteomes" id="UP000694394">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2200:FF:000002">
        <property type="entry name" value="cbp/p300-interacting transactivator 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007576">
        <property type="entry name" value="CITED"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045:SF6">
        <property type="entry name" value="CBP_P300-INTERACTING TRANSACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17045">
        <property type="entry name" value="MELANOCYTE SPECIFIC GENE RELATED CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04487">
        <property type="entry name" value="CITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015130.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="227" mass="23147" checksum="D15503096CAF5A6C" modified="2022-01-19" version="1">MEPSGHQRQLAASSPANLSSFCQGSEMPTMSRPALDVKGGTSPAKEDANQEMSSLAYSNLGVKDRKAVAVLHYPAVASVASNGTKASGAPTSPLGSPAAIGSPTSSTPTKTPPFNLHPAPHLLASMQLQKLNSQYHGMAAAAAATPGQPGEAGPLPNWGFGAQAGGAGSLSPPTGAQSPTIIDSDPVDEEVLMSLVVELGLDRADELPELWLGQNEFDFTADFPSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEG0</accession>
    <name>A0A8C5VEG0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03036773">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VEG0"/>
    <dbReference type="Ensembl" id="ENSMICT00000029469.2">
        <property type="protein sequence ID" value="ENSMICP00000021419.2"/>
        <property type="gene ID" value="ENSMICG00000032024.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162763"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1210:FF:000001">
        <property type="entry name" value="melanoma-associated antigen D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1200">
        <property type="entry name" value="MAGE homology domain, winged helix WH1 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1210">
        <property type="entry name" value="MAGE homology domain, winged helix WH2 motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037445">
        <property type="entry name" value="MAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041898">
        <property type="entry name" value="MAGE_WH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041899">
        <property type="entry name" value="MAGE_WH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002190">
        <property type="entry name" value="MHD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736">
        <property type="entry name" value="MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11736:SF83">
        <property type="entry name" value="TROPHININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01454">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01373">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50838">
        <property type="entry name" value="MAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAGE" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021419.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="276" mass="31593" checksum="C37FD182831C3CE9" modified="2022-01-19" version="1">GDERSGSNYRPHHPRDVAILQERANKLVKYLLVRTKDPHQALRCAEGCHPECEEYYPEIMNEQMFRVNLKEIDKQSSLYILISNQESSTGILGTTKESPKLGLLMVLLSIIFMNGNRSSGAVIWEVLRKLGLRPGVKHSLFGEVRKLITDEFVKQKYLEYKRVPNSRPPEYEFFWGLRSYHETSKMKVLKFACKVQKKDPKDWASQYREAVEMEVQAAAVAVAVAEAEARAEVYSPHLQIPLMNCNSPSHGVKIHPWNLCPHISLSSHDQTAEDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VFS8</accession>
    <name>A0A8C5VFS8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate rich 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ERICH4</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VFS8"/>
    <dbReference type="Ensembl" id="ENSMICT00000043756.2">
        <property type="protein sequence ID" value="ENSMICP00000022150.1"/>
        <property type="gene ID" value="ENSMICG00000033248.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006319"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029202">
        <property type="entry name" value="DUF4530"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36879">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36879:SF1">
        <property type="entry name" value="GLUTAMATE-RICH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15039">
        <property type="entry name" value="DUF4530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="133" mass="14870" checksum="6E38E4AACD591533" modified="2022-01-19" version="1">MELWRQLREAGLVPPWLGPPPRALRGVSPVQSPGQTRMSPGTDTGGARESLLQIWEELGKLRQADVQLLGQLCSLGLQMKALHEDLVAILEEEEDSCEEEEEEEDEEPQRKQEEEHLGAFCPAPGPPDFEMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHG3</accession>
    <name>A0A8C5VHG3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105856602</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03016428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VHG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000044981.2">
        <property type="protein sequence ID" value="ENSMICP00000020440.1"/>
        <property type="gene ID" value="ENSMICG00000033371.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155043"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd12936">
        <property type="entry name" value="GUCT_RHII_Gualpha_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2280:FF:000002">
        <property type="entry name" value="Nucleolar RNA helicase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001168">
        <property type="entry name" value="nucleolar RNA helicase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF19">
        <property type="entry name" value="NUCLEOLAR RNA HELICASE 2-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="213"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="401"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="676"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="694"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="718"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="730"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="741" mass="82072" checksum="6CBEDCC1D12C3120" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJN9</accession>
    <name>A0A8C5VJN9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cdk5 and Abl enzyme substrate 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CABLES1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000031816.2">
        <property type="protein sequence ID" value="ENSMICP00000024542.2"/>
        <property type="gene ID" value="ENSMICG00000009282.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00400000022086"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20602">
        <property type="entry name" value="CYCLIN_CABLES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000020">
        <property type="entry name" value="CDK5 and ABL1 enzyme substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012388">
        <property type="entry name" value="CABLES1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22896:SF1">
        <property type="entry name" value="CDK5 AND ABL1 ENZYME SUBSTRATE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025798">
        <property type="entry name" value="Cables"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="7">
        <location>
            <begin position="494"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024542.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="599" mass="64477" checksum="39600B4F27AA6577" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJW2</accession>
    <name>A0A8C5VJW2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Galanin receptor type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GALR1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with GRP39 AND HTR1A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03022834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602412.1">
        <property type="nucleotide sequence ID" value="XM_012746958.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJW2"/>
    <dbReference type="Ensembl" id="ENSMICT00000034323.2">
        <property type="protein sequence ID" value="ENSMICP00000023845.1"/>
        <property type="gene ID" value="ENSMICG00000036654.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105861468"/>
    <dbReference type="KEGG" id="mmur:105861468"/>
    <dbReference type="CTD" id="2587"/>
    <dbReference type="GeneTree" id="ENSGT01150000286969"/>
    <dbReference type="OrthoDB" id="2132067at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004966">
        <property type="term" value="F:galanin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051464">
        <property type="term" value="P:positive regulation of cortisol secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15098">
        <property type="entry name" value="7tmA_Gal1_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000135">
        <property type="entry name" value="galanin receptor type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003906">
        <property type="entry name" value="GAL1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF25">
        <property type="entry name" value="GALANIN RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01418">
        <property type="entry name" value="GALANIN1R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 16" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="52"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="351" mass="39073" checksum="598C4CAE4299474E" modified="2022-01-19" version="1">MEQAAGNLSEGNGSGSRAEPPAAEQRPLFGIGVENFITLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSVADLAYLLFCIPFQATVYALPTWVLGAFICKFVHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRASALRVSRNVLLGVGFIWALSIAMASPMAYHQGLFHPNASNQTFCWEHWPNKRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTILVVVVVFGVSWLPHHVIHLWAEFGQFPLTPASFLFRVAAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHLRTESPVSGNRENKSRVDTPPSTNCTHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VK23</accession>
    <name>A0A8C5VK23_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit alpha type-6</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024594">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VK23"/>
    <dbReference type="Ensembl" id="ENSMICT00000038941.2">
        <property type="protein sequence ID" value="ENSMICP00000023941.1"/>
        <property type="gene ID" value="ENSMICG00000030926.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074807"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26650" checksum="67EDCC6AAEC94852" modified="2022-01-19" version="1">MMCTDTSRGASACFDHHITMFSPEGWPYTSVAVRGKDWGVIVTQKKVPDTLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRTRCEAANWKYKYGYEIPVDVLCKRIADISQVYMQNAEMRPLGCCMILIDIEEEQGPQVYKCDPAGYYCGFKATAEGIKQTESTKKFDWTFEQTEETAIICLSTVLSIDFKPSEIEGEVVTAENPKFRILTEAEIDAHLVALAERLNIVTSLPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VKZ0</accession>
    <name>A0A8C5VKZ0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L7-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002720">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VKZ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000052344.2">
        <property type="protein sequence ID" value="ENSMICP00000022514.2"/>
        <property type="gene ID" value="ENSMICG00000037323.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182878"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF13">
        <property type="entry name" value="RIBOSOMAL PROTEIN UL30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="98"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022514.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26735" checksum="C3C2F8665E4D88EF" modified="2022-01-19" version="1">MISSGNTGTMGEQEERKSIPLVPENLLKRRKAYQALKATQAKQALLAKKQQRKGKGPRFKQLELFLHDSWQQQRDRVRLRRLEVKSHALKLQDKHSLAFVVRIQRINGVSSLVQKTISRLRLKKIFSGVFVRVTPQSLKLLRMVEPYSVRELILKCGQAKVKNKTIPLTDNTVIEEHLGKFDVICLEDLIHEIALPGKHFQEISCFLCPFQLSVASHATKNKVGFLKEMGSPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VML9</accession>
    <name>A0A8C5VML9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="15">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC105857903</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">Clathrin-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">Secretory vesicle</location>
            <location evidence="12">Synaptic vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VML9"/>
    <dbReference type="Ensembl" id="ENSMICT00000048222.2">
        <property type="protein sequence ID" value="ENSMICP00000022788.1"/>
        <property type="gene ID" value="ENSMICG00000028804.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155068"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF5">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B, BRAIN ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="17">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="16">
        <location>
            <begin position="168"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="18">
        <location>
            <begin position="387"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="493" mass="54762" checksum="5E1F12CA793306C6" modified="2022-01-19" version="1">MRGIVNRAAPQLPVSTSGPVVGSREQVLAVSRNYLSQPRLTYKTVSGVNGPLVILDHVKFPRYAEIVHLTLPDGTKRSGQVLEVSGSKAVVQVFEGTSGIDAKKTSCEFTGDILRTPVSEDMLGRVFNGSGKPIDKGPVVLAEDFLDIMGQPINPQCRIYPEEMIQTGISAIDGMNSIARGQKIPIFSAAGLPHNEIAAQICRQAGLVKKSKDVVDYSEENFAIVFAAMGVNMETARFFKSDFEENGSMDNVCLFLNLANDPTIERIITPRLALTIAEFLAYQCEKHVLVILTDMSSYAEALREVSAAREEVPGRRGFPGYMYTDLATIYERIPILTMPNDDITHPIPDLTGYITEGQICVDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHADVSNQLYACYAIGKDVQAMKAVVGEEALTSDDLLYLEFLQKFERNFIAQGPYENRTVYETLDIGWQLLRIFPKEMLKRIPQSTLSEFYPRDSAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VTB7</accession>
    <name>A0A8C5VTB7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Unconventional myosin-XIX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Myosin head domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MYO19</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments. Required for mitochondrial inheritance during mitosis. May be involved in mitochondrial transport or positioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin light chains MYL9 and MYL12B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019989">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633118.1">
        <property type="nucleotide sequence ID" value="XM_012777664.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633204.1">
        <property type="nucleotide sequence ID" value="XM_012777750.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VTB7"/>
    <dbReference type="Ensembl" id="ENSMICT00000053923.2">
        <property type="protein sequence ID" value="ENSMICP00000026746.1"/>
        <property type="gene ID" value="ENSMICG00000004193.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878305"/>
    <dbReference type="KEGG" id="mmur:105878305"/>
    <dbReference type="CTD" id="80179"/>
    <dbReference type="GeneTree" id="ENSGT00940000157382"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032027">
        <property type="term" value="F:myosin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060002">
        <property type="term" value="F:plus-end directed microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034642">
        <property type="term" value="P:mitochondrion migration along actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160040">
        <property type="term" value="P:mitocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090140">
        <property type="term" value="P:regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14880">
        <property type="entry name" value="MYSc_Myo19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000035">
        <property type="entry name" value="Unconventional myosin-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000013">
        <property type="entry name" value="Unconventional myosin-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000014">
        <property type="entry name" value="unconventional myosin-XIX isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036035">
        <property type="entry name" value="MYSc_Myo19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF289">
        <property type="entry name" value="UNCONVENTIONAL MYOSIN-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 19" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9 19" id="KW-0518">Myosin</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="21">
        <location>
            <begin position="35"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="19">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00054433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="959" mass="108068" checksum="2F911A0CFB3D74B9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VUD4</accession>
    <name>A0A8C5VUD4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium-coupled monocarboxylate transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Electrogenic sodium monocarboxylate cotransporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 5 member 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">SLC5A8</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72959"/>
            <dbReference type="ChEBI" id="CHEBI:10983"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72935"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72967"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72971"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58402"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72947"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72963"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>bromide(in) = bromide(out)</text>
            <dbReference type="Rhea" id="RHEA:75383"/>
            <dbReference type="ChEBI" id="CHEBI:15858"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72951"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>iodide(out) = iodide(in)</text>
            <dbReference type="Rhea" id="RHEA:66324"/>
            <dbReference type="ChEBI" id="CHEBI:16382"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>nicotinate(out) + 2 Na(+)(out) = nicotinate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72955"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>nitrate(in) = nitrate(out)</text>
            <dbReference type="Rhea" id="RHEA:34923"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>propanoate(out) + 2 Na(+)(out) = propanoate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72939"/>
            <dbReference type="ChEBI" id="CHEBI:17272"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>pyruvate(out) + 2 Na(+)(out) = pyruvate(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72943"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 30">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009233">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628097.1">
        <property type="nucleotide sequence ID" value="XM_012772643.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VUD4"/>
    <dbReference type="Ensembl" id="ENSMICT00000050196.2">
        <property type="protein sequence ID" value="ENSMICP00000025534.1"/>
        <property type="gene ID" value="ENSMICG00000029503.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105875552"/>
    <dbReference type="CTD" id="160728"/>
    <dbReference type="GeneTree" id="ENSGT00940000155166"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015129">
        <property type="term" value="F:lactate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140161">
        <property type="term" value="F:monocarboxylate:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090416">
        <property type="term" value="F:nicotinate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015552">
        <property type="term" value="F:propionate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006846">
        <property type="term" value="P:acetate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006821">
        <property type="term" value="P:chloride transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015705">
        <property type="term" value="P:iodide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015706">
        <property type="term" value="P:nitrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006848">
        <property type="term" value="P:pyruvate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11519">
        <property type="entry name" value="SLC5sbd_SMCT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000007">
        <property type="entry name" value="Sodium-coupled monocarboxylate transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041992">
        <property type="entry name" value="SLC5sbd_SMCT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051163">
        <property type="entry name" value="Sodium:Solute_Symporter_SSF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42985:SF10">
        <property type="entry name" value="SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 31" id="KW-0472">Membrane</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 31" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 31" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="31">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00035085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00035086"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00035088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00035089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00035095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="611" mass="66955" checksum="D2C7F7ABDC5F220C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWR5</accession>
    <name>A0A8C5VWR5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">COPB1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006358">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636175.1">
        <property type="nucleotide sequence ID" value="XM_012780721.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636176.1">
        <property type="nucleotide sequence ID" value="XM_012780722.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWR5"/>
    <dbReference type="Ensembl" id="ENSMICT00000045643.2">
        <property type="protein sequence ID" value="ENSMICP00000029386.2"/>
        <property type="gene ID" value="ENSMICG00000010919.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879997"/>
    <dbReference type="KEGG" id="mmur:105879997"/>
    <dbReference type="CTD" id="1315"/>
    <dbReference type="GeneTree" id="ENSGT00390000005270"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="23"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="14">
        <location>
            <begin position="667"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="15">
        <location>
            <begin position="813"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029386.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="953" mass="107142" checksum="129F031B1E64DEB3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VXQ8</accession>
    <name>A0A8C5VXQ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">medium-chain acyl-CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ACSM6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48340"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:59558"/>
            <dbReference type="ChEBI" id="CHEBI:90546"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:48341"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.2" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03020981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VXQ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000038560.2">
        <property type="protein sequence ID" value="ENSMICP00000032522.2"/>
        <property type="gene ID" value="ENSMICG00000030864.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000165168"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000007">
        <property type="entry name" value="Acyl-coenzyme A synthetase ACSM2A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051087">
        <property type="entry name" value="Mitochondrial_ACSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43605:SF1">
        <property type="entry name" value="ACYL-COENZYME A SYNTHETASE ACSM6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="16">
        <location>
            <begin position="82"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032522.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="480" mass="53649" checksum="935ECFCB6754E4B8" modified="2022-01-19" version="1">MLGQFQLFSLVRGCSRLGCGSCCQPKRKFAAQTVKYSGSRPIGQAVPQHFNFAKDVLDQWSQLEKDGLRGPCPALWEVDAKGKEDKWSFERMACLSQKAASILSDTCALGHKDRLMIILPPTPETYWIFLACVRLGITFVPGTPQLRAKEILYRLCMSKARCIVANETMAPVVDSVMSDCPSLKTKLLVSDKSYDGWLDFRELIRVAPPKQTFMETKSQDPMAIFFTNRTMGAPKLVEYSQYGLGMEFSQVLRQWMDLQPTDVLWSLGDIFGGTLSLSTVLGAWLQGACVFLYHMPTFCPETVLNALSRFPITTLCGKPEMYQELLQHKHFISYRFKSLKHCMAAGGSISPGVIKDWKRITNLDIYEGYGQTETGLLCATSKRMKLKPGSLGKPLPPYTVQIVDENSNILPVGEEGNIAVRITLNQPASVYCPHMVSWEEYASGRSQMLYLTGDRGIMDEDGYFWLAGRADGVADILGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYP8</accession>
    <name>A0A8C5VYP8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leucine-rich repeat and fibronectin type-III domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC105869313</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LRFN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004147">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616456.1">
        <property type="nucleotide sequence ID" value="XM_012761002.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYP8"/>
    <dbReference type="Ensembl" id="ENSMICT00000053995.2">
        <property type="protein sequence ID" value="ENSMICP00000033113.2"/>
        <property type="gene ID" value="ENSMICG00000029663.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158296"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905606">
        <property type="term" value="P:regulation of presynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099560">
        <property type="term" value="P:synaptic membrane adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05764">
        <property type="entry name" value="IgI_SALM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000025">
        <property type="entry name" value="Leucine rich repeat and fibronectin type III domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000235">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000091">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000016">
        <property type="entry name" value="Leucine-rich repeat and fibronectin type III domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050467">
        <property type="entry name" value="LRFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842:SF10">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45842">
        <property type="entry name" value="SYNAPTIC ADHESION-LIKE MOLECULE SALM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150174" description="Leucine-rich repeat and fibronectin type-III domain-containing protein 5" evidence="16">
        <location>
            <begin position="18"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="524"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="17">
        <location>
            <begin position="287"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="616"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="628"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="649"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037389"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033113.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="719" mass="79555" checksum="4798A4FB8D964C48" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYU1</accession>
    <name>A0A8C5VYU1_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Agenet-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMR1 family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5VYU1"/>
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        <property type="protein sequence ID" value="ENSMICP00000030525.2"/>
        <property type="gene ID" value="ENSMICG00000033163.2"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183189"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
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    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:mRNA transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of mRNA stability"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000017">
        <property type="entry name" value="Fragile X mental retardation syndrome-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022034">
        <property type="entry name" value="FMR1-like_C_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032172">
        <property type="entry name" value="FXR1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047495">
        <property type="entry name" value="KH_I_FXR1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF6">
        <property type="entry name" value="RNA-BINDING PROTEIN FXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12235">
        <property type="entry name" value="FXMRP1_C_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16096">
        <property type="entry name" value="FXR_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18336">
        <property type="entry name" value="Tudor_FRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51641">
        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
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        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030525.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="537" mass="60209" checksum="8908DBBFF6B1B25F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2H0</accession>
    <name>A0A8C5W2H0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hematopoietic cell signal transducer</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNAX-activation protein 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Membrane protein DAP10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HCST</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026971">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2H0"/>
    <dbReference type="Ensembl" id="ENSMICT00000041394.2">
        <property type="protein sequence ID" value="ENSMICP00000032573.2"/>
        <property type="gene ID" value="ENSMICG00000028917.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012777"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050776">
        <property type="term" value="P:regulation of immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009861">
        <property type="entry name" value="HCST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21409">
        <property type="entry name" value="HEMATOPOIETIC CELL SIGNAL TRANSDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21409:SF1">
        <property type="entry name" value="HEMATOPOIETIC CELL SIGNAL TRANSDUCER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07213">
        <property type="entry name" value="DAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032573.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="91" mass="9374" checksum="D5A4646AAF8D8DD3" modified="2022-01-19" version="1">AIVSGHILLLFSQVTPAAMGPGRRDWLPRPGRSAGSCSACGPLSLPLLAGLVAADAVVSLLIVGAVFLCARLGHRPTQEDGRVYINMPGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2T5</accession>
    <name>A0A8C5W2T5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018823">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2T5"/>
    <dbReference type="Ensembl" id="ENSMICT00000038631.2">
        <property type="protein sequence ID" value="ENSMICP00000032439.1"/>
        <property type="gene ID" value="ENSMICG00000036935.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017780"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM17-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15560" checksum="41CADF7F38665FFB" modified="2022-01-19" version="1">MEEYAREPCLCQIVDDCGGAFTMGTIGGGIFQAIKGSLTAIKTRAPQLGGSFAVWGGLFSMIDCGMVQVRGKEDPWTSITSGALTGAILAARNEPVAMAGSAEMGGAGILSTRFASAQFPNGPQFAEDPSQLPSIQLPSSPFGDYRQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W6P7</accession>
    <name>A0A8C5W6P7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Transcriptional coactivator YAP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Protein yorkie homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Yes-associated protein YAP65 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">YAP1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the YAP1 family.</text>
    </comment>
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            <dbReference type="Ensembl" id="ENSMICP00000034882.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="506" mass="54578" checksum="20D18A133D2E934D" modified="2022-01-19" version="1">MDPGQQQPPQPAPQGQGQPPAQTPQGQGPPSGPGQPAPPASQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRKLPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLNPTGVVSGPAATPAAQHLRQSSFEIPDDVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAPVKQPPPLAPQSPQGGVMGGGSSNQQQQMRLQQLQMEKERLRLKQQELLRQAMRNINPSTANSPKCQELALRSQLPTLEQDGGTQNAVSSPGMSQELRTMTTNSSDPFLNSGTYHSRDESTDSGLSMSSYSVPRTPDDFLNSVDEMDTGDTINQSTLPSQQNRFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAATKLDKESFLTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W9H1</accession>
    <name>A0A8C5W9H1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03034921">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W9H1"/>
    <dbReference type="Ensembl" id="ENSMICT00000034432.2">
        <property type="protein sequence ID" value="ENSMICP00000034932.1"/>
        <property type="gene ID" value="ENSMICG00000036912.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163231"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000032">
        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47595:SF2">
        <property type="entry name" value="MYB_SANT-LIKE DNA-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="2">
        <location>
            <begin position="11"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="352" mass="38739" checksum="F7BBB31EF1681134" modified="2022-01-19" version="1">MASTNSSAGIQWSRQETRTLLSILGEAEYIQHLQTVHHNADVYQAVSKRMQQKGFRRTERQCRSKFKVLKALYLKAYVAHATSMGDPPHCAFYDTLDQLLRNQIVTDPDNLMEDAAWAKHCDQTLVASDTPGEEGTSILKAKRTQAADLRPILKTLRISNRIRETSDLEDSWDESPGAGCSQGTPTYSNSHNLFRGAVAPCQSSPMTRLGVSGEPGPCTSTSCNTPGAASAPRPPVSSPRVGFVSGGDRPLTSEPPPRWARRRRRSVARTIAAELAENRRLARELSKREEEKLDRLIAIGEEASAQQDTTNELRRDAVIAVRCLATAVEEATGAFQLGLEKLLQKLISNTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XBX1</accession>
    <name>A0A8C5XBX1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Calmodulin-lysine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CAMKMT</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the trimethylation of 'Lys-116' in calmodulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21556"/>
            <dbReference type="Rhea" id="RHEA-COMP:11360"/>
            <dbReference type="Rhea" id="RHEA-COMP:11361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.60"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with HSP90, probably as a client.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.60" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03011825">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611640.1">
        <property type="nucleotide sequence ID" value="XM_012756186.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XBX1"/>
    <dbReference type="Ensembl" id="ENSMICT00000004937.3">
        <property type="protein sequence ID" value="ENSMICP00000004501.3"/>
        <property type="gene ID" value="ENSMICG00000034768.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105866691"/>
    <dbReference type="KEGG" id="mmur:105866691"/>
    <dbReference type="CTD" id="79823"/>
    <dbReference type="GeneTree" id="ENSGT00390000002168"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018025">
        <property type="term" value="F:calmodulin-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000140">
        <property type="entry name" value="Calmodulin-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025800">
        <property type="entry name" value="CaM-Lys-N-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13539:SF3">
        <property type="entry name" value="CALMODULIN-LYSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51610">
        <property type="entry name" value="SAM_CLNMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00061919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004501.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="323" mass="36114" checksum="3664CCE6C2DE06CF" modified="2022-01-19" version="1">MESQIADSLAGETARAAGGGPAMGNAAEGPTVSAPLGAARWKLLRQVLKQKHVDDCLRHVSVRRFESFNLFSVTETQKRETEEEVGAWVQYTSVFHPEYSISLRHNNGSLNVEDVLTSFDNTGNVCIWPSEEVLAYYCLKHSSMFRDLAVCELGGGMTCLAGLMVAISADVKEVLLTDGNEKAIRNVRDIIARNQKAGVFKTQKISSCVLRWDNETDVSQLEGHFDIVMCADCLFLDQYRASLVDAIKRLLQPRGKAMVFAPRRGNTLNQFCNLAEKAGFSIQRHENYDEHISNFHSKLKKENPNIYEENLHYPLLLTLTKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XD04</accession>
    <name>A0A8C5XD04_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22 23">Serine/threonine-protein kinase RIO3</fullName>
            <ecNumber evidence="4 23">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">RIOK3</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with CASP10. Interacts with IRF3; RIOK3 probably mediates the interaction of TBK1 with IRF3. Associated with 40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 23"/>
    <dbReference type="EMBL" id="ABDC03022975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XD04"/>
    <dbReference type="Ensembl" id="ENSMICT00000009292.3">
        <property type="protein sequence ID" value="ENSMICP00000008465.2"/>
        <property type="gene ID" value="ENSMICG00000009293.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157008"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05146">
        <property type="entry name" value="RIO3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000254">
        <property type="entry name" value="Serine/threonine-protein kinase RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000200">
        <property type="entry name" value="Serine/threonine-protein kinase RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017406">
        <property type="entry name" value="Ser/Thr_kinase_Rio3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038146">
        <property type="entry name" value="Ser/Thr_PK_RIO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 23" id="KW-0391">Immunity</keyword>
    <keyword evidence="9 23" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="13 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="15 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 23" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="25">
        <location>
            <begin position="222"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="121"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00057551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008465.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="519" mass="58764" checksum="3F08286A16329458" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDR2</accession>
    <name>A0A8C5XDR2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 231</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TMEM231</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Part of the tectonic-like complex (also named B9 complex). Interacts with TMEM107.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM231 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024138">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDR2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011971.3">
        <property type="protein sequence ID" value="ENSMICP00000010900.3"/>
        <property type="gene ID" value="ENSMICG00000011968.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015366"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043010">
        <property type="term" value="P:camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042733">
        <property type="term" value="P:embryonic digit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060563">
        <property type="term" value="P:neuroepithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001944">
        <property type="term" value="P:vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019306">
        <property type="entry name" value="TMEM231"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605">
        <property type="entry name" value="CHST5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14605:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10149">
        <property type="entry name" value="TM231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010900.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="315" mass="35920" checksum="7211D2625624F40D" modified="2022-01-19" version="1">MALHELFSHPVERGYRAGLCSKAALFLLLAAALTYIPPLLVAFRSHGFWLKRSSYEEQPTVRFQHQVLLVALLGPEPGGVLAWSTFPAFNRLQGDRLRVPLVSTREEDRNQDGKMDRLHFKLELPLQSTEHILGVQLILTFSYQLHRMSTFVMQSMAFLQSSFAVPGSQLHVNGDLRLQQRQPLSYGGLDVRYNVSVINGTSPFACDYDLTHIVAAYQERNVTTILDDPNPIWLVGRAAEAPFVIDAVIRYPVEVISYPLHERMIKFAWVQYVSILLIFLWVFERIKIFVFQNQVVTTVPANAMPHGEVYKEHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XE44</accession>
    <name>A0A8C5XE44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aspartate beta-hydroxylase domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ASPHD2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May function as 2-oxoglutarate-dependent dioxygenase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartyl/asparaginyl beta-hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612130.1">
        <property type="nucleotide sequence ID" value="XM_012756676.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XE44"/>
    <dbReference type="Ensembl" id="ENSMICT00000013666.3">
        <property type="protein sequence ID" value="ENSMICP00000012468.2"/>
        <property type="gene ID" value="ENSMICG00000013677.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866974"/>
    <dbReference type="CTD" id="57168"/>
    <dbReference type="GeneTree" id="ENSGT00940000159252"/>
    <dbReference type="OrthoDB" id="438431at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000011">
        <property type="entry name" value="Aspartate beta-hydroxylase domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007803">
        <property type="entry name" value="Asp/Arg/Pro-Hydrxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051821">
        <property type="entry name" value="Asp/Asn_beta-hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46332:SF3">
        <property type="entry name" value="ASPARTATE BETA-HYDROXYLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05118">
        <property type="entry name" value="Asp_Arg_Hydrox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Aspartyl/asparaginy/proline hydroxylase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012468.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="345" mass="38936" checksum="4A4C4F8865BDE233" modified="2022-01-19" version="1">MSLEWLVAWSWSLDGLRDCIATGIQSVRDCDTTAVVTVACLLVLFVWYCYHVGREQPRPFAAVNSLMQAAGADADGLQNGYAYCQAPECVRCAHNEGLNQKLYHNLQEYAKRYSWSGMGRIHKGIREQGRYLNSRPSIQKPEVFFLPDLPTTPYFSRDAQKHDVELLERNFQTILCEFEALYKAFSNCSLPQGWKMNSTPSGEWFTYYLVNQGVCVPRNCRRCPRTYRLLGSLRTCIGNNVFGNACISMLSPGTVITEHYGPTNIRIRCHLGLKTPNGCELVVGGEPQCWAEGRCLLFDDSFLHTAFHEGPAEDGPRVVFMVDLWHPNVAAAERQALDFIFAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XF25</accession>
    <name>A0A8C5XF25_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC105866338</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XF25"/>
    <dbReference type="Ensembl" id="ENSMICT00000017360.3">
        <property type="protein sequence ID" value="ENSMICP00000015814.3"/>
        <property type="gene ID" value="ENSMICG00000035756.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000829">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF138">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034466861" description="Ig-like domain-containing protein" evidence="14">
        <location>
            <begin position="17"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="144"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="234"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015814.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="463" mass="50448" checksum="69C67616C9DA0DB7" modified="2022-01-19" version="1">MLLLLALLWGTAGVEGWGGYRLQVQSVVTVQEGLCVRVSCSFPCPLYHWRDSDPIHGYWFREGASVERDAPVVTNNPARKVQEETRGQFHLLGDLRRNDCSLSIRDATMRVEGSYFFGVERELMKWNYEQNKLVVQVTALTHTPDILLPETLECGHPSTLTCSVPWACEQGTRPHISWEGASVAPQGPTIGRSSVLTLVPQPQDHGSSLTCQVTLPGAGVTTTRTVHLNVSYSPQNLTVTVFHGNGSVTGLGNGSSVSVLEGQYLRLVCVVNSNPPARITWTWGRLTLNPSQPLGPGELELPRVHLRDEGEFCRAQNPLGSQHVSLSLSLQTKDTATVQPVSGVMLGVVWGAKATALVFLSFCVIFIVVRSRRRKAARAAAGVGDTGVEEPDAVRVPGSRVSLIEPQAGDSRPDQAPPAVASPISRQEQEVQYTSVSFLKRKAQDTVGQEATGREYSEIKIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XG13</accession>
    <name>A0A8C5XG13_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="21">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 21">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20 21">Belongs to the RPAP2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03004659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XG13"/>
    <dbReference type="Ensembl" id="ENSMICT00000046299.2">
        <property type="protein sequence ID" value="ENSMICP00000018662.2"/>
        <property type="gene ID" value="ENSMICG00000036371.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017965"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.820:FF:000001">
        <property type="entry name" value="RNA polymerase II subunit B1 CTD phosphatase Rpap2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 21" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 21" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10 21" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9 21" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="23">
        <location>
            <begin position="75"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018662.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="528" mass="60109" checksum="98073093D7D3FFA0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGK7</accession>
    <name>A0A8C5XGK7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">La ribonucleoprotein 1, translational regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LARP1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LARP family.</text>
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    <dbReference type="EMBL" id="ABDC03027482">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000020261.2"/>
        <property type="gene ID" value="ENSMICG00000000837.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159577"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
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        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08037">
        <property type="entry name" value="LARP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000131">
        <property type="entry name" value="la-related protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DM15"/>
    </dbReference>
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        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF51">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="194"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="310"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="559"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="612"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="825"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="134"/>
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        </location>
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        <location>
            <begin position="381"/>
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        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="853"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="882"/>
            <end position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020261.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="894" mass="102717" checksum="6160972A788929B0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHU2</accession>
    <name>A0A8C5XHU2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein FAM76B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FAM76B</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006690">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012743908.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5XHU2"/>
    <dbReference type="Ensembl" id="ENSMICT00000032223.2">
        <property type="protein sequence ID" value="ENSMICP00000023901.1"/>
        <property type="gene ID" value="ENSMICG00000036906.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105859777"/>
    <dbReference type="CTD" id="143684"/>
    <dbReference type="GeneTree" id="ENSGT00940000159074"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043031">
        <property type="term" value="P:negative regulation of macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046826">
        <property type="term" value="P:negative regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF3">
        <property type="entry name" value="PROTEIN FAM76B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="338" mass="38550" checksum="99DFB0ABE579AA13" modified="2022-01-19" version="1">MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCRSEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGPPQTCEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSLTDKDQHHAKHHHHHHHHHHRHSSSHHKISNLSPEQEQGLWKQSHKSSAAIQNETPKKKPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKKLTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGSILTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XI72</accession>
    <name>A0A8C5XI72_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">COMM domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COMMD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the COMM domain-containing protein 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005055">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XI72"/>
    <dbReference type="Ensembl" id="ENSMICT00000028193.2">
        <property type="protein sequence ID" value="ENSMICP00000025065.2"/>
        <property type="gene ID" value="ENSMICG00000036432.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012029"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031462">
        <property type="term" value="C:Cul2-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070300">
        <property type="term" value="F:phosphatidic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019871">
        <property type="term" value="F:sodium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000009">
        <property type="term" value="P:negative regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902306">
        <property type="term" value="P:negative regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048227">
        <property type="term" value="P:plasma membrane to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04749">
        <property type="entry name" value="Commd1_MURR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017920">
        <property type="entry name" value="COMM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033776">
        <property type="entry name" value="COMMD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037351">
        <property type="entry name" value="Murr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21199:SF1">
        <property type="entry name" value="COMM DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07258">
        <property type="entry name" value="COMM_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17221">
        <property type="entry name" value="COMMD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51269">
        <property type="entry name" value="COMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COMM" evidence="3">
        <location>
            <begin position="117"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025065.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="189" mass="21075" checksum="BC0BBA8C558180B9" modified="2022-01-19" version="1">MAGELESCKPLGGLLSGLAQEAFHGHPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWDSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKIGQESEFLCLEFDEVKVNQILKKLSEVEESINTLISQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XIN7</accession>
    <name>A0A8C5XIN7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitogen-activated protein kinase kinase kinase kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MAP4K5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03004252">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XIN7"/>
    <dbReference type="Ensembl" id="ENSMICT00000052308.2">
        <property type="protein sequence ID" value="ENSMICP00000026299.2"/>
        <property type="gene ID" value="ENSMICG00000015101.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158072"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06646">
        <property type="entry name" value="STKc_MAP4K5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000031">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021160">
        <property type="entry name" value="MAPKKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF19">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038172">
        <property type="entry name" value="MAPKKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="17">
        <location>
            <begin position="506"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="372"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038172-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026299.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="846" mass="95083" checksum="BD8B723B4D3EF3F8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XKT3</accession>
    <name>A0A8C5XKT3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Zinc finger protein 658</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ZNF658</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014078">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XKT3"/>
    <dbReference type="Ensembl" id="ENSMICT00000040726.2">
        <property type="protein sequence ID" value="ENSMICP00000032553.2"/>
        <property type="gene ID" value="ENSMICG00000042550.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163669"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071294">
        <property type="term" value="P:cellular response to zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004935">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000688">
        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001437">
        <property type="entry name" value="Zinc finger protein 594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000361">
        <property type="entry name" value="Zinc finger protein 658"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001745">
        <property type="entry name" value="Zinc finger protein 658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003209">
        <property type="entry name" value="Zinc finger protein 658B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000416">
        <property type="entry name" value="zinc finger protein 879 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050752">
        <property type="entry name" value="C2H2-ZF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384">
        <property type="entry name" value="FINGER PUTATIVE TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24384:SF246">
        <property type="entry name" value="GENE, 19965-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="372"/>
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            <begin position="397"/>
            <end position="424"/>
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        <location>
            <begin position="425"/>
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        <location>
            <begin position="453"/>
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        <location>
            <begin position="481"/>
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        <location>
            <begin position="509"/>
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        <location>
            <begin position="537"/>
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        <location>
            <begin position="565"/>
            <end position="592"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="593"/>
            <end position="620"/>
        </location>
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        <location>
            <begin position="621"/>
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        <location>
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        <location>
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            <end position="789"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00003767"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032553.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="798" mass="92383" checksum="E0D04D3B3AAF609D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XMK9</accession>
    <name>A0A8C5XMK9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LSM2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XMK9"/>
    <dbReference type="Ensembl" id="ENSMICT00000049232.2">
        <property type="protein sequence ID" value="ENSMICP00000037749.2"/>
        <property type="gene ID" value="ENSMICG00000034824.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016597"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120115">
        <property type="term" value="C:Lsm2-8 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037749.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="84" mass="9693" checksum="CD3FA6CCC9FAD6CE" modified="2022-01-19" version="1">MLFYSFFKSLVGKDVVVELKNDLYLNIKLTDISVTDPEKYPHMLSVKNCFIRGSVVRYVQLPADEVDTQLLQDAARKEALQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XN97</accession>
    <name>A0A8C5XN97_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Forkhead box B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FOXB2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03014299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615232.1">
        <property type="nucleotide sequence ID" value="XM_012759778.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XN97"/>
    <dbReference type="Ensembl" id="ENSMICT00000045671.2">
        <property type="protein sequence ID" value="ENSMICP00000038070.1"/>
        <property type="gene ID" value="ENSMICG00000032613.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105868702"/>
    <dbReference type="KEGG" id="mmur:105868702"/>
    <dbReference type="CTD" id="442425"/>
    <dbReference type="GeneTree" id="ENSGT00940000161970"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20043">
        <property type="entry name" value="FH_FOXB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000082">
        <property type="entry name" value="forkhead box protein B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047389">
        <property type="entry name" value="FOXB1_B2_FH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF215">
        <property type="entry name" value="FORKHEAD BOX PROTEIN B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Fork-head" evidence="8">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="13"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="431" mass="45275" checksum="61973F33F9B98CCE" modified="2022-01-19" version="1">MPRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIMERFPYYREHTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSFLRRRKRFKVLRADHAHLHAGSTKGAPGAGPGGHLHPHHPHHPHHHHHHHAAAHHHHHHHPPQPPPPPPPPHMVHYFHQQPPTAPQPPPHLPSQPPQPPPQQSQPQQPSHPGKMQEAAAVAAAAAAAAAAAVGSVGRLSQFPPYGLGSAAAAAAAAAASTSGFKHPFAIENIIGRDYKGVLQAGGLPLASVMHHLGYPVPGQLGNVVSSVWPHVGVMDSVAAAAAAAAAAGVPVGPEYGAFGVPVKALCHSASQSLPAVPVPIKPTPALPPVTALPPALTVPAASQQPPTPSTVCSAAAASPVASLLEPTAPSAAAESKGGSLHSVLVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTK0</accession>
    <name>A0A8C5XTK0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CDGSH iron-sulfur domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC105867072</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion outer membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the CISD protein family. CISD2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03031216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTK0"/>
    <dbReference type="Ensembl" id="ENSMICT00000069471.1">
        <property type="protein sequence ID" value="ENSMICP00000041236.1"/>
        <property type="gene ID" value="ENSMICG00000047325.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105874831"/>
    <dbReference type="CTD" id="493856"/>
    <dbReference type="GeneTree" id="ENSGT00940000156660"/>
    <dbReference type="OrthoDB" id="449252at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.90:FF:000001">
        <property type="entry name" value="CDGSH iron-sulfur domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045131">
        <property type="entry name" value="CISD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019610">
        <property type="entry name" value="FeS-contain_mitoNEET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680:SF33">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10660">
        <property type="entry name" value="MitoNEET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="13">
        <location>
            <begin position="81"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="144" mass="16193" checksum="44F3CCB7B8811001" modified="2022-01-19" version="1">MVLESVARIVKVQLPAYLKRLPVPESISGFARLTVSEWLRLLPFLGVLALLGYLAVRPFLSKKKQQKDSLINLKIQKENPKVVNEINIEDLCLTKAAYCRCWRSKTFPACDGSHNKHNELTGDNVGPLILEEKNILQLGLNSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUP1</accession>
    <name>A0A8C5XUP1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myosin light chain kinase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MYLK3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024401">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUP1"/>
    <dbReference type="Ensembl" id="ENSMICT00000067427.1">
        <property type="protein sequence ID" value="ENSMICP00000041559.1"/>
        <property type="gene ID" value="ENSMICG00000046381.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160007"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905710">
        <property type="term" value="P:positive regulation of membrane permeability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905075">
        <property type="term" value="P:positive regulation of tight junction disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000196">
        <property type="entry name" value="Myosin light chain kinase family, member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000135">
        <property type="entry name" value="Putative myosin light chain kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342:SF20">
        <property type="entry name" value="MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24342">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="212"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="516" mass="56274" checksum="FEB9FBEB69D93580" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XV65</accession>
    <name>A0A8C5XV65_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Complement factor properdin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CFP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03036542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603752.1">
        <property type="nucleotide sequence ID" value="XM_012748298.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XV65"/>
    <dbReference type="Ensembl" id="ENSMICT00000070305.1">
        <property type="protein sequence ID" value="ENSMICP00000041485.1"/>
        <property type="gene ID" value="ENSMICG00000047059.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105862183"/>
    <dbReference type="KEGG" id="mmur:105862183"/>
    <dbReference type="CTD" id="5199"/>
    <dbReference type="GeneTree" id="ENSGT00940000161209"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098548">
        <property type="term" value="C:cytoplasmic side of Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006957">
        <property type="term" value="P:complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045958">
        <property type="term" value="P:positive regulation of complement activation, alternative pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000001">
        <property type="entry name" value="semaphorin-5A isoform X1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049536">
        <property type="entry name" value="CFP_TSR-0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054019">
        <property type="entry name" value="CFP_TSR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22195">
        <property type="entry name" value="TSP1_CFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18487">
        <property type="entry name" value="TSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01705">
        <property type="entry name" value="TSP1REPEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150368" evidence="6">
        <location>
            <begin position="28"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="469" mass="51407" checksum="1425658CA7DF56A6" modified="2022-01-19" version="1">MTACAQAPQWLLLLLLLLPLLTLPATGSDPVLCFAQYEESSGKCKDLLGSVKVEDCCLNAAFAFQEDGSKICQICRFPRWSPWSTWTPCSAKCSEGSQLRHRRCVGRDGKCSEKAVPGTLEWQLQACEDQPCCPEMGGWSDWGPWKPCSVTCSKGIQIRERACNHPAPKCGGHCPGETQESQDCDSKQVCPTHGAWATWGPWSPCSGSCHGGSHAPMETRSRTCSAPEPSQKPPGKTCPGPAYEQRSCPGLLPCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCDHPVPQHGGPFCAGDATRTHICNTAVPCPVDGEWEAWGQWNTCTRPNIKSISCKEIPGQQTRLRTCKGRKFNGQRCAGQYQDIRHCYNIEGCVWKGSWAEWSTWGLCMPPCGPEPTRVRRRLCTALLPKYPPTISMVEGQGEKNVTFWGTPRALCDMLQGQRLVVEEKRPCLLVPACKDPEDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVZ7</accession>
    <name>A0A8C5XVZ7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Flap endonuclease 1</fullName>
            <shortName evidence="17">FEN-1</shortName>
            <ecNumber evidence="17">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 17">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity. The C-terminal domain binds EP300; can bind simultaneously to both PCNA and EP300. Interacts with DDX11; this interaction is direct and increases flap endonuclease activity of FEN1. Interacts with WDR4; regulating its endonuclease activity. Interacts with POLB.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with PCNA1 and PCNA2. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Nucleus</location>
            <location evidence="17">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Nucleus</location>
            <location evidence="17">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="17">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 17">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03035105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035106">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035107">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XVZ7"/>
    <dbReference type="Ensembl" id="ENSMICT00000064997.1">
        <property type="protein sequence ID" value="ENSMICP00000042123.1"/>
        <property type="gene ID" value="ENSMICG00000045504.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155807"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 17" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 17" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="21">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="20">
        <location>
            <begin position="127"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00063178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="365" mass="41059" checksum="D249C3D322B4A26C" modified="2022-01-19" version="1">MTHKKLINWTSQKLKTAFGKPLSVELIGQGGDVLQNEEGETTSHLMGMFYRTIHMMKNGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEEEVEKFTKRLVKVTKQHNDECKHLLSLMSIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQQLGLSQEQFVDLCILLGSDYYESIWGIGPKRAKHKSIEEIVRRLDPNKYPVLENWLHKEAQRLFLEPEVLDPESVELKWSETNEEELVKFMCGESGVKRLPQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSAKKKAKTGTTNILNLSLPSFHSLLLLLYVKLSPLIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1I4</accession>
    <name>A0A8C5Y1I4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serum amyloid A protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC105879971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Major acute phase reactant. Apolipoprotein of the HDL complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SAA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636099.1">
        <property type="nucleotide sequence ID" value="XM_012780645.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y1I4"/>
    <dbReference type="Ensembl" id="ENSMICT00000067723.1">
        <property type="protein sequence ID" value="ENSMICP00000044729.1"/>
        <property type="gene ID" value="ENSMICG00000042509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879971"/>
    <dbReference type="KEGG" id="mmur:105879971"/>
    <dbReference type="GeneTree" id="ENSGT00390000004737"/>
    <dbReference type="OrthoDB" id="6112826at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034364">
        <property type="term" value="C:high-density lipoprotein particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035662">
        <property type="term" value="F:Toll-like receptor 4 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006953">
        <property type="term" value="P:acute-phase response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071347">
        <property type="term" value="P:cellular response to interleukin-1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035634">
        <property type="term" value="P:response to stilbenoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.110:FF:000001">
        <property type="entry name" value="Serum amyloid A protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.110">
        <property type="entry name" value="Serum amyloid A protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000096">
        <property type="entry name" value="Serum_amyloid_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052464">
        <property type="entry name" value="Synovial_Prolif_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424">
        <property type="entry name" value="SERUM AMYLOID A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23424:SF29">
        <property type="entry name" value="SERUM AMYLOID A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00277">
        <property type="entry name" value="SAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002472">
        <property type="entry name" value="Serum_amyloid_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00306">
        <property type="entry name" value="SERUMAMYLOID"/>
    </dbReference>
    <dbReference type="SMART" id="SM00197">
        <property type="entry name" value="SAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00992">
        <property type="entry name" value="SAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0011">Acute phase</keyword>
    <keyword evidence="3 4" id="KW-0345">HDL</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150429" description="Serum amyloid A protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="122" mass="13565" checksum="81F3A40301DCCF29" modified="2022-01-19" version="1">MKLSIGIIFFCLVLGVSGQRWLSFIKEAGQGSKDMWRAYSDMREANFKNSDKYFHARGNYDAAQRGPGGAWAAKVISDAREGIQRLTGHGAEDSRADQAANKWGRSGKDPNHFRPKGLPSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y390</accession>
    <name>A0A8C5Y390_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Solute carrier family 13 member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC13A4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015201">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600210.1">
        <property type="nucleotide sequence ID" value="XM_012744756.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y390"/>
    <dbReference type="Ensembl" id="ENSMICT00000065393.1">
        <property type="protein sequence ID" value="ENSMICP00000045547.1"/>
        <property type="gene ID" value="ENSMICG00000042199.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065598.1">
        <property type="protein sequence ID" value="ENSMICP00000044594.1"/>
        <property type="gene ID" value="ENSMICG00000042199.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105860199"/>
    <dbReference type="CTD" id="26266"/>
    <dbReference type="GeneTree" id="ENSGT01030000234550"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015370">
        <property type="term" value="F:solute:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF63">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="8" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="627" mass="69278" checksum="12153AEA25D63D16" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3Y2</accession>
    <name>A0A8C5Y3Y2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Synaptotagmin-8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Synaptotagmin VIII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">SYT8</name>
        <name evidence="18" type="synonym">TNNI2</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer or homooligomer. Homodimerization and homooligomerization do not depend on Ca(2+). Interacts with SYNCRIP isoform 2 C-terminus. Binds inositol 1,3,4,5-tetrakisphosphate (IP4). Binds to AP2 in a Ca(2+)-independent manner. Interacts with STX1A, STX1B and STX2; the interaction is Ca(2+)-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Acrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005909">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3Y2"/>
    <dbReference type="Ensembl" id="ENSMICT00000059950.1">
        <property type="protein sequence ID" value="ENSMICP00000045799.1"/>
        <property type="gene ID" value="ENSMICG00000031880.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160892"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031045">
        <property type="term" value="C:dense core granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048791">
        <property type="term" value="P:calcium ion-regulated exocytosis of neurotransmitter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000176">
        <property type="entry name" value="Synaptotagmin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000182">
        <property type="entry name" value="Synaptotagmin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF249">
        <property type="entry name" value="SYNAPTOTAGMIN-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00399">
        <property type="entry name" value="SYNAPTOTAGMN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="106"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="17">
        <location>
            <begin position="234"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="388" mass="42298" checksum="02D1A9D7F305D151" modified="2022-01-19" version="1">MGHPADAHSTPAPAGTTAGPGLVPDLVARTPWPHWALAAVTLAAGVLVASCILCAICRCCHRRRRRRKEPREKEAVGLGRAHSTTTPCPVQPDVDTLGCGPGEPQQWGRLQLALEYDRGSQEIRVRLKQAADLKAAGTADPYARVSVSTQPGRWHETKVHRGVLCPEFEETCCFLVPPAELPGATLQVQLLDFKRFSGHEPLGALSLALGTEDLQHVLERWFQLGPPGTAQPELLGELCVSLRYVPGAGRLCVAVLEARGLRPGPTELYVKVQLMLGQRRWKKRRTSARKGSASPYFNEAFTFLLPVSQVQSADLVLAVWARGPQLRAEPVGKVLLGAHASGQPLQHWADALAHARRPVAQWHRLQPAGEVDRTLAPQPRLRLPLPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YBR4</accession>
    <name>A0A8C5YBR4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Serine/threonine-protein kinase VRK1</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Vaccinia-related kinase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">VRK1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with HDAC1, KAT2B, SETDB1, KDM3A and KDM4A. Associates with the nucleosome through interactions with nucleosome DNA, histone H2A and histone H2B; the interaction with H2A and H2B is mediated by the nucleosome acidic patch, a cluster of negatively charged residues of H2A and H2B forming a cleft within the nucleosome core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Cajal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03003540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646518.1">
        <property type="nucleotide sequence ID" value="XM_012791064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YBR4"/>
    <dbReference type="Ensembl" id="ENSMICT00000063516.1">
        <property type="protein sequence ID" value="ENSMICP00000048727.1"/>
        <property type="gene ID" value="ENSMICG00000030687.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065661.1">
        <property type="protein sequence ID" value="ENSMICP00000046932.1"/>
        <property type="gene ID" value="ENSMICG00000030687.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885808"/>
    <dbReference type="CTD" id="7443"/>
    <dbReference type="GeneTree" id="ENSGT00940000155554"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:Cajal body"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd14122">
        <property type="entry name" value="STKc_VRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="serine/threonine-protein kinase VRK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="37"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061699"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062338"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="396" mass="45234" checksum="FAAB0385DA9021F4" modified="2022-01-19" version="1">MPRVKAAQSGRQGPAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADTNSSKSVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTHKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLSYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENITGLMDKCFPEKNKPGEIAKYMETVKLLGYTEKPLYQNLRDILLQGLKAIGSKDDGKLDLSVVENGGLKAKASTKKRKKEIEETTESSVEDMECSNTQTEEAIQTRSRTRKRVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGQ4</accession>
    <name>A0A8C5YGQ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA-binding protein 42</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA-binding motif protein 42</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RBM42</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with HNRNPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRM RBM42 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630487.1">
        <property type="nucleotide sequence ID" value="XM_012775033.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGQ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000062838.1">
        <property type="protein sequence ID" value="ENSMICP00000049997.1"/>
        <property type="gene ID" value="ENSMICG00000009880.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876922"/>
    <dbReference type="KEGG" id="mmur:105876922"/>
    <dbReference type="CTD" id="79171"/>
    <dbReference type="GeneTree" id="ENSGT00930000151055"/>
    <dbReference type="OMA" id="QRMPMMR"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048025">
        <property type="term" value="P:negative regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000189">
        <property type="entry name" value="RNA-binding protein 42 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="378"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="477" mass="50137" checksum="545D91434A10C8E0" modified="2022-01-19" version="1">MAGAGPAPGLPGAGGPVVPGPGAGIPGKSGEERLKEMEAEMALFEQEVLGAPVTGIPTAVPAVPTVPTVEAMQVPAAPVIRPIIATNTYQQVQQTLEARAAAAATVVPPMVGGPPFVGPVGFGPGDRSHLDSPEAREAMFLRRAAVAPQRAPILRPAFVPHVLQRADSALSSAAGGPRPMALRPPHQALVGPPLPGPPGPPMMLPPMARAPGPPLGSMAALRPPLEEPTAPRELGLGLGLGLKEKEEAVVAAAAGLEEASAAVAVGAGGAPAGPAVIGPSLPLALAMPLPEPEPLPLPLEVVRGLLPPLRIPELLSLRPRPRPPRPEPPPGLMALEVPEPLGEDKKKGKPEKLKRCIRTAAGSSWEDPSLLEWDADDFRIFCGDLGNEVNDDILARAFSRFPSFLKAKVIRDKRTGKTKGYGFVSFKDPSDYVRAMREMNGKYVGSRPIKLRKSMWKDRNLDVVRKKQKEKKKLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGZ6</accession>
    <name>A0A8C5YGZ6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Filamin A interacting protein 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">FILIP1L</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGZ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000073026.1">
        <property type="protein sequence ID" value="ENSMICP00000051332.1"/>
        <property type="gene ID" value="ENSMICG00000049406.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182852"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050719">
        <property type="entry name" value="Cortactin-Actin_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019131">
        <property type="entry name" value="Cortactin-binding_p2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166:SF4">
        <property type="entry name" value="FILAMIN A-INTERACTING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23166">
        <property type="entry name" value="FILAMIN/GPBP-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09727">
        <property type="entry name" value="CortBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cortactin-binding protein-2 N-terminal" evidence="4">
        <location>
            <begin position="66"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="260"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="618"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1133" mass="130339" checksum="20F053EFA12BC2BB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YH19</accession>
    <name>A0A8C5YH19_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Retinol binding protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RBP2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000014">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YH19"/>
    <dbReference type="Ensembl" id="ENSMICT00000072315.1">
        <property type="protein sequence ID" value="ENSMICP00000051266.1"/>
        <property type="gene ID" value="ENSMICG00000048996.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160165"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000001">
        <property type="entry name" value="Fatty acid-binding protein, adipocyte"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000463">
        <property type="entry name" value="Fatty_acid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031259">
        <property type="entry name" value="ILBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11955">
        <property type="entry name" value="FATTY ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00178">
        <property type="entry name" value="FATTYACIDBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Lipocalin/cytosolic fatty-acid binding" evidence="3">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="12669" checksum="8F4AABA651EAE9CD" modified="2022-01-19" version="1">IDFATRKIAAHLTQTKIIDQDGDNFKTQTNSTFRNYNLDFTVGVEFDEHTKGLDNRLVKTLVNWEGDVLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHJ4</accession>
    <name>A0A8C5YHJ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03000926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHJ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000073091.1">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
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        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ELONGATNFCT"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
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        <property type="entry name" value="G_TR_2"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="4"/>
            <end position="241"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
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    <sequence length="420" mass="45291" checksum="EF33441A5D79730B" modified="2022-01-19" version="1">MGKEKTSVIIVIGHVDSGKSTTTGHLIYKCAGIDKRTIKKFEKEVAEMGKDSFRYAWVLDKLKAEREPGITIDISLWKFETSKYYVTLIDAPGHRDFIKNMIIGTSQADCAVLIVAAGVGELEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYNQKRYEDIVKEVSTDINKIGYNPDTVAFMPISGWNGDNMLEPSASMPWFKGWKVTRKDGNASGTTLLEALGCILLPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMMVTSAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVCHGNVAGDSKNDPPMEAAGFTAQVIILNHAGQISAGYTPVLDCHTAHIACKFDGPKFLKSGDAAIVNMVPGKPVCVKSFSDYPPLGSSCCSCSCSGEFHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJA2</accession>
    <name>A0A8C5YJA2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">C-C motif chemokine receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CCR2</name>
        <name evidence="13" type="synonym">CCR5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ENSMICG00000049181.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105874441"/>
    <dbReference type="KEGG" id="mmur:105874441"/>
    <dbReference type="GeneTree" id="ENSGT01020000230359"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031727">
        <property type="term" value="F:CCR2 chemokine receptor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035716">
        <property type="term" value="F:chemokine (C-C motif) ligand 12 binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0035715">
        <property type="term" value="F:chemokine (C-C motif) ligand 2 binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035717">
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        <property type="term" value="P:blood vessel remodeling"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030097">
        <property type="term" value="P:hemopoiesis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061756">
        <property type="term" value="P:leukocyte adhesion to vascular endothelial cell"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002548">
        <property type="term" value="P:monocyte chemotaxis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:monocyte extravasation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:2000464">
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    <dbReference type="GO" id="GO:0120162">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:2000473">
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    </dbReference>
    <dbReference type="GO" id="GO:0090265">
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    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032743">
        <property type="term" value="P:positive regulation of interleukin-2 production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903238">
        <property type="term" value="P:positive regulation of leukocyte tethering or rolling"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0090026">
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    <dbReference type="GO" id="GO:2000439">
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    <dbReference type="GO" id="GO:0051968">
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    </dbReference>
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    <dbReference type="GO" id="GO:0002724">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of vascular endothelial growth factor production"/>
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        <property type="term" value="P:sensory perception of pain"/>
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        <property type="term" value="P:T-helper 17 cell chemotaxis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="7tmA_CCR5_CCR2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C-C chemokine receptor type 5"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
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    <dbReference type="InterPro" id="IPR002237">
        <property type="entry name" value="Chemokine_CCR2"/>
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    <dbReference type="InterPro" id="IPR000355">
        <property type="entry name" value="Chemokine_rcpt"/>
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    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
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    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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    <dbReference type="PANTHER" id="PTHR10489:SF913">
        <property type="entry name" value="C-C CHEMOKINE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00657">
        <property type="entry name" value="CCCHEMOKINER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01107">
        <property type="entry name" value="CHEMOKINER2"/>
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    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
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    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="154"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="191"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
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            <begin position="221"/>
            <end position="242"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="272"/>
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    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="72"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051239.1"/>
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    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="373" mass="42166" checksum="BDCAE95724AD63C6" modified="2022-01-19" version="1">MDDKDTSPQLIRSTSSPYHSLFARDGDMNSEEATTVYDYDYGAPCNKFDVKQIGAQLLPPLYSLVFIFGLVGNLLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTIPFWAHYAANGWVLGDAMCKLFAGLYHVGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVATSGVTWMVSVLASVPGIIFTKSHKDDSVYFCGPYFPLVWKNFHTIMRNVLGLFLPLLVMVICYSGILKTLLRCRNEKKRHKAVRLIFAIMIVYFLFWTPYNLVILLSTFQGFFGLSTCESTSRLDQAMQVTETLGMTHCCINPVIYTFVGEKFRRYLSVFFRKYIAKHLCKQCPVFYGETADRVTSTYTPSTGEQEVSAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJV3</accession>
    <name>A0A8C5YJV3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">FMR1 autosomal homolog 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FXR1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoplasmic ribonucleoprotein granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Postsynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000924">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YJV3"/>
    <dbReference type="Ensembl" id="ENSMICT00000072875.1">
        <property type="protein sequence ID" value="ENSMICP00000051455.1"/>
        <property type="gene ID" value="ENSMICG00000048978.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183189"/>
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        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007517">
        <property type="term" value="P:muscle organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048170">
        <property type="term" value="P:positive regulation of long-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099577">
        <property type="term" value="P:regulation of translation at presynapse, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22504">
        <property type="entry name" value="KH_I_FXR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22507">
        <property type="entry name" value="KH_I_FXR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22510">
        <property type="entry name" value="KH_I_FXR1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20475">
        <property type="entry name" value="Tudor_Agenet_FXR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000001">
        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000004">
        <property type="entry name" value="Fragile X mental retardation 1, isoform CRA_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000017">
        <property type="entry name" value="Fragile X mental retardation syndrome-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040148">
        <property type="entry name" value="FMR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022034">
        <property type="entry name" value="FMR1-like_C_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040472">
        <property type="entry name" value="FMRP_KH0"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032172">
        <property type="entry name" value="FXR1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032177">
        <property type="entry name" value="FXR_C3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
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    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
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    <dbReference type="InterPro" id="IPR047494">
        <property type="entry name" value="KH_I_FXR1_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047495">
        <property type="entry name" value="KH_I_FXR1_rpt2"/>
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    <dbReference type="InterPro" id="IPR047496">
        <property type="entry name" value="KH_I_FXR1_rpt3"/>
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    <dbReference type="InterPro" id="IPR047427">
        <property type="entry name" value="Tudor_Agenet_FXR1_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041560">
        <property type="entry name" value="Tudor_FRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603">
        <property type="entry name" value="FRAGILE X MENTAL RETARDATION SYNDROME-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10603:SF6">
        <property type="entry name" value="RNA-BINDING PROTEIN FXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12235">
        <property type="entry name" value="FXMRP1_C_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16096">
        <property type="entry name" value="FXR_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16097">
        <property type="entry name" value="FXR_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17904">
        <property type="entry name" value="KH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51641">
        <property type="entry name" value="AGENET_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0517">Myogenesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Agenet-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="350"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="498"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="647" mass="72913" checksum="96448C24C8A0C402" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJY6</accession>
    <name>A0A8C5YJY6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000742">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YJY6"/>
    <dbReference type="Ensembl" id="ENSMICT00000073414.1">
        <property type="protein sequence ID" value="ENSMICP00000051305.1"/>
        <property type="gene ID" value="ENSMICG00000049190.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157910"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050459">
        <property type="term" value="F:ethanolamine-phosphate phospho-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF1">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE PHOSPHO-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="64" mass="7307" checksum="E8BEB433E07482EB" modified="2022-01-19" version="1">MCELYSKGDTLALPGRHVGPSCKVFFAADPMKIVRAQRQYMFDKKGERYLDCINNVAHDLKPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6ECB3</accession>
    <name>A0A8C6ECB3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Voltage-dependent T-type calcium channel subunit alpha-1H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Voltage-gated calcium channel subunit alpha Cav3.2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">CACNA1H</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Interacts (via N-terminal cytoplasmic domain) with STAC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020774">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000036987.2">
        <property type="protein sequence ID" value="ENSMICP00000038433.2"/>
        <property type="gene ID" value="ENSMICG00000027405.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156666"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008332">
        <property type="term" value="F:low voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097110">
        <property type="term" value="F:scaffold protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032342">
        <property type="term" value="P:aldosterone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032870">
        <property type="term" value="P:cellular response to hormone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034651">
        <property type="term" value="P:cortisol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000344">
        <property type="term" value="P:positive regulation of acrosome reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000557">
        <property type="entry name" value="Voltage-dependent calcium channel type A subunit alpha-1-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000014">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000018">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000053">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000054">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000007">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000008">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000009">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000012">
        <property type="entry name" value="Voltage-dependent T-type calcium channel subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005445">
        <property type="entry name" value="VDCC_T_a1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
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                <person name="Gibbs R.A."/>
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        </source>
    </evidence>
    <sequence length="210" mass="24016" checksum="76F092F4118BFA51" modified="2022-01-19" version="1">PQPAPSEACARQLLLQDWAPLGGGLRLPPSLSWNVLLLRRPLYRNLLRINIYEPAPPTGPTQRPLETLGNFRGWHIRTEMLHKDLSWTVKQQCVDLLAEGLWEELLDDEQPDITVMDWFEDSRLDACVYELHVWLLAADRRSVIAQHHAAPRTTGRGAPGCWVQVSHVFRHYGPGVRFVHFLHKSKNRMVPGGLQRTRVTDSSVSVQLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EIZ6</accession>
    <name>A0A8C6EIZ6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatidylinositol specific phospholipase C X domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">PLCXD1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03036261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EIZ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000070055.1">
        <property type="protein sequence ID" value="ENSMICP00000045351.1"/>
        <property type="gene ID" value="ENSMICG00000045160.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161625"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF24">
        <property type="entry name" value="PI-PLC X DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="233" mass="25944" checksum="4A7F877302D551F9" modified="2022-01-19" version="1">TLDVTEQLDAGVRYMDLRIAHVLGGAERNLHFVHTVYTTALVEDTLTEISEWLEKHPREVVILACRNFEGMTQDLHEYLVTCIKNIFGDMLCPRGEVPTLRQLWSREQQVLVSYEDESCVGRHCELWPGIPYWWGNKVKTEALIRYLESMKSKGRPGGGGGGGINLTESLAYILAHPSQSLRGLTLPGLPRLCAWVREQRPGPGPRCTCVIAGDFVGAGTFVGDVVGLNRKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJQ6</accession>
    <name>A0A8C6EJQ6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pygopus family PHD finger 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PYGO1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in signal transduction through the Wnt pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03004497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638533.1">
        <property type="nucleotide sequence ID" value="XM_012783079.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJQ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000066427.1">
        <property type="protein sequence ID" value="ENSMICP00000046875.1"/>
        <property type="gene ID" value="ENSMICG00000035806.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105881416"/>
    <dbReference type="CTD" id="26108"/>
    <dbReference type="GeneTree" id="ENSGT00530000063948"/>
    <dbReference type="OrthoDB" id="270215at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007289">
        <property type="term" value="P:spermatid nucleus differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15635">
        <property type="entry name" value="PHD_PYGO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000107">
        <property type="entry name" value="pygopus homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052475">
        <property type="entry name" value="Wnt_Signal_Transd_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194">
        <property type="entry name" value="PYGOPUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23194:SF3">
        <property type="entry name" value="PYGOPUS HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0879">Wnt signaling pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="419" mass="45401" checksum="8ED6A3E20D9BE89E" modified="2022-01-19" version="1">MSAEQEKDPISLKRVRGGDSGLDGLGGPGVQLGSPDKKKRKANTQGPSFPPLSEYAPPPNPNSDHLVAANPFDDNYNTISYKPLPSSNPYLGPGYPGFGGYSTFRMPPHVPPRMSSPYCGPYSLRNQPHPFPQNPLGMGFNRPHAFNFGPHDNSSFGNPSYNNALSQNVNMPNQHFRQNPAENFSQIPPQNATQVSNPDLASNFVPGNNSNFTSPLESNHSFIPPPNTFGQAKAPPPKQDFSQGATKNTNQNSSAHPPHLNMDDTVNQSNIELKNVNRNNAVNQENSRSSSTEATNNNHANGTQNKPRQPRSAADTCTTEKSNKSSLHPSRHGHSSSDPVYPCGICTNEVNDDQDAILCEASCQKWFHRICTGMTETAYGLLTAEASAVWGCDTCMADKDVQLMRTRETFGPPTVGGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2001-12-01" modified="2026-01-28" version="121" xmlns="https://uniprot.org/uniprot">
    <accession>Q94N31</accession>
    <name>Q94N31_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">NADH-ubiquinone oxidoreductase chain 4L</fullName>
            <ecNumber evidence="3 19">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ND4L</name>
        <name evidence="36" type="synonym">MT-ND4L</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="20 36"/>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2001" name="Mol. Phylogenet. Evol." volume="19" first="45" last="56">
            <title>Molecular phylogeny of the lemur family cheirogaleidae (primates) based on mitochondrial DNA sequences.</title>
            <authorList>
                <person name="Pastorini J."/>
                <person name="Martin R.D."/>
                <person name="Ehresmann P."/>
                <person name="Zimmermann E."/>
                <person name="Forstner M.R."/>
            </authorList>
            <dbReference type="PubMed" id="11286490"/>
            <dbReference type="DOI" id="10.1006/mpev.2000.0904"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="journal article" date="2003" name="Proc. Natl. Acad. Sci. U.S.A." volume="100" first="5879" last="5884">
            <title>A molecular approach to comparative phylogeography of extant Malagasy lemurs.</title>
            <authorList>
                <person name="Pastorini J."/>
                <person name="Thalmann U."/>
                <person name="Martin R.D."/>
            </authorList>
            <dbReference type="PubMed" id="12719521"/>
            <dbReference type="DOI" id="10.1073/pnas.1031673100"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="journal article" date="2006" name="Int. J. Primatol." volume="27" first="347" last="389">
            <title>Revision of the Mouse Lemurs (Microcebus) of Eastern Madagascar.</title>
            <authorList>
                <person name="Louis E.E.Jr."/>
                <person name="Coles M.S."/>
                <person name="Andriantompohavana R."/>
                <person name="Sommer J.A."/>
                <person name="Engberg S.E."/>
                <person name="Sommer J.R."/>
                <person name="Mayor M.I."/>
                <person name="Brenneman R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="22">MOR100</strain>
            <strain evidence="23">MOR114</strain>
            <strain evidence="24">MOR128</strain>
            <strain evidence="25">MOR131</strain>
            <strain evidence="21">MOR62</strain>
        </source>
    </reference>
    <reference evidence="21" key="4">
        <citation type="journal article" date="2006" name="Occas. Pap. Mus. Tex. Tech Univ." volume="259" first="1" last="24">
            <title>Mouse lemurs of Northwestern Madagascar with a description of a new species at Lokobe Special Reserve.</title>
            <authorList>
                <person name="Andriantompohavana R."/>
                <person name="Zaonarivelo J.R."/>
                <person name="Engberg S.E."/>
                <person name="Randriamampionona R."/>
                <person name="McGuire S.M."/>
                <person name="Shore G.D."/>
                <person name="Rakotonomenjanahary R."/>
                <person name="Brenneman R.A."/>
                <person name="Louis E.E.Jr."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">MOR62</strain>
        </source>
    </reference>
    <reference evidence="26" key="5">
        <citation type="submission" date="2010-03" db="EMBL/GenBank/DDBJ databases">
            <title>Even More Diversity Revealed in the Genus Microcebus.</title>
            <authorList>
                <person name="Ranaivoarisoa J.F."/>
                <person name="Lei R."/>
                <person name="Nash S."/>
                <person name="Mittermeier R.A."/>
                <person name="Engberg S.E."/>
                <person name="Mcguire S.M."/>
                <person name="Kimmel L.M."/>
                <person name="Randriamampionona R."/>
                <person name="Andriamihaja J.A."/>
                <person name="Sitzmann B.D."/>
                <person name="Louis E.E. Jr."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">HAZO5.9</strain>
            <strain evidence="29">MOR116</strain>
            <strain evidence="30">MOR129</strain>
            <strain evidence="31">MOR130</strain>
            <strain evidence="27">MOR37</strain>
            <strain evidence="28">MOR75</strain>
        </source>
    </reference>
    <reference evidence="34" key="6">
        <citation type="journal article" date="2016" name="Mitochondrial DNA A DNA Mapp Seq Anal" volume="27" first="3514" last="3516">
            <title>Complete mitochondrial genome of the gray mouse lemur, Microcebus murinus (Primates, Cheirogaleidae).</title>
            <authorList>
                <person name="Lecompte E."/>
                <person name="Crouau-Roy B."/>
                <person name="Aujard F."/>
                <person name="Holota H."/>
                <person name="Murienne J."/>
            </authorList>
            <dbReference type="PubMed" id="27158869"/>
            <dbReference type="DOI" id="10.3109/19401736.2015.1074196"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="34">203A</strain>
            <strain evidence="35">920FAG</strain>
        </source>
    </reference>
    <reference evidence="32" key="7">
        <citation type="book" date="2016" name="THE DWARF AND MOUSE LEMURS OF MADAGASCAR" first="0" last="0" publisher="Cambridge University Press">
            <title>Mitogenomics of the family Cheirogaleidae and relationships to taxonomy and biogeography in Madagascar.</title>
            <editorList>
                <person name="Lehman"/>
                <person name="S.M. and Radespiel"/>
                <person name="U. and Zimmermann"/>
                <person name="E."/>
            </editorList>
            <authorList>
                <person name="Louis E.E. Jr."/>
                <person name="Lei R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="32">HAZO5.9</strain>
            <strain evidence="33">KIR6.32</strain>
        </source>
    </reference>
    <reference evidence="36" key="8">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:29092"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion inner membrane</location>
            <topology evidence="1 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="3 19"/>
    <dbReference type="EMBL" id="AF224624">
        <property type="protein sequence ID" value="AAK70549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AF224629">
        <property type="protein sequence ID" value="AAK70569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY582654">
        <property type="protein sequence ID" value="AAS92807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY582655">
        <property type="protein sequence ID" value="AAS92811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY582656">
        <property type="protein sequence ID" value="AAS92815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY582657">
        <property type="protein sequence ID" value="AAS92819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY582658">
        <property type="protein sequence ID" value="AAS92823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GU954241">
        <property type="protein sequence ID" value="ADM93008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GU954242">
        <property type="protein sequence ID" value="ADM93012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GU954243">
        <property type="protein sequence ID" value="ADM93016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GU954246">
        <property type="protein sequence ID" value="ADM93028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ADM93032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GU954248">
        <property type="protein sequence ID" value="ADM93036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM112298">
        <property type="protein sequence ID" value="AIW63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM112304">
        <property type="protein sequence ID" value="AIW63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KR911907">
        <property type="protein sequence ID" value="ALP29111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KR911908">
        <property type="protein sequence ID" value="ALP29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009192257.1">
        <property type="nucleotide sequence ID" value="NC_028718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q94N31"/>
    <dbReference type="SMR" id="Q94N31"/>
    <dbReference type="Ensembl" id="ENSMICT00000052666.1">
        <property type="protein sequence ID" value="ENSMICP00000032216.1"/>
        <property type="gene ID" value="ENSMICG00000037683.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26823982"/>
    <dbReference type="KEGG" id="mmur:26823982"/>
    <dbReference type="CTD" id="4539"/>
    <dbReference type="GeneTree" id="ENSGT00390000004755"/>
    <dbReference type="OrthoDB" id="6146597at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMICG00000037683">
        <property type="expression patterns" value="Expressed in adult mammalian kidney and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434:SF0">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 19 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 19" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0520">NAD</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="13 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AAK70569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="AAS92807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AAS92811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="AAS92815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="AAS92819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AAS92823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="ADM93008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="ADM93012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="ADM93016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="ADM93028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="ADM93032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="ADM93036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="AIW63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="AIW63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="ALP29111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="ALP29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="98" mass="10786" checksum="F214423DAB26CADF" modified="2001-12-01" version="1">MPSISINIILAFTAALLGMLMFRSHMMSSLLCLEGMMLSMFILSTLIILNMQFTMSFIMPILLLVFAACEAAIGLALLVTVSNIYGLDHIQNLNLLQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ECY1</accession>
    <name>A0A8B7ECY1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Required for excision 1-B domain containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">REX1BD</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027593">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591126.1">
        <property type="nucleotide sequence ID" value="XM_012735672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ECY1"/>
    <dbReference type="Ensembl" id="ENSMICT00000048331.2">
        <property type="protein sequence ID" value="ENSMICP00000035029.1"/>
        <property type="gene ID" value="ENSMICG00000038301.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105855014"/>
    <dbReference type="KEGG" id="mmur:105855014"/>
    <dbReference type="CTD" id="55049"/>
    <dbReference type="GeneTree" id="ENSGT00390000011631"/>
    <dbReference type="OrthoDB" id="434723at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039491">
        <property type="entry name" value="REX1-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28309">
        <property type="entry name" value="REQUIRED FOR EXCISION 1-B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28309:SF1">
        <property type="entry name" value="REQUIRED FOR EXCISION 1-B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14966">
        <property type="entry name" value="DNA_repr_REX1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="176" mass="19547" checksum="B331B1AA0CE8E4CF" modified="2022-01-19" version="1">MIGSEAAAGSAPGAQASAGAPGREEPRWPWRDAPVRTLVQRVHQLQAERARAFRRLEEGHREYLRSGPCYDFPRYRSTVHEVTQAFAAASREVLALEAELAGPRAQPRLAGHVRSLQQLEQTRLATVALLQLMGTPEWTGQEDAVQAHQLKTKVIKTMEAISEVLQDLRFDVESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EGS1</accession>
    <name>A0A8B7EGS1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nidogen-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Entactin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">NID1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with FBLN1. Interacts with LGALS3BP. Interacts with PLXDC1. Interacts with SVEP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
            <location evidence="1">Basement membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593739.1">
        <property type="nucleotide sequence ID" value="XM_012738285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EGS1"/>
    <dbReference type="Ensembl" id="ENSMICT00000050940.2">
        <property type="protein sequence ID" value="ENSMICP00000020290.1"/>
        <property type="gene ID" value="ENSMICG00000002600.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856490"/>
    <dbReference type="KEGG" id="mmur:105856490"/>
    <dbReference type="CTD" id="4811"/>
    <dbReference type="GeneTree" id="ENSGT00940000156318"/>
    <dbReference type="OrthoDB" id="9990982at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043237">
        <property type="term" value="F:laminin-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043394">
        <property type="term" value="F:proteoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042813">
        <property type="term" value="F:Wnt receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032836">
        <property type="term" value="P:glomerular basement membrane development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010811">
        <property type="term" value="P:positive regulation of cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00255">
        <property type="entry name" value="nidG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00191">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000270">
        <property type="entry name" value="Nidogen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000281">
        <property type="entry name" value="Nidogen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000297">
        <property type="entry name" value="Nidogen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000030">
        <property type="entry name" value="Nidogen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.155.10:FF:000001">
        <property type="entry name" value="Nidogen 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000666">
        <property type="entry name" value="nidogen-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.10:FF:000001">
        <property type="entry name" value="Testican-3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.155.10">
        <property type="entry name" value="Green fluorescent protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.10">
        <property type="entry name" value="Thyroglobulin type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050778">
        <property type="entry name" value="Cueball_EGF_LRP_Nidogen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006605">
        <property type="entry name" value="G2_nidogen/fibulin_G2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009017">
        <property type="entry name" value="GFP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000716">
        <property type="entry name" value="Thyroglobulin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036857">
        <property type="entry name" value="Thyroglobulin_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513:SF6">
        <property type="entry name" value="NIDOGEN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46513">
        <property type="entry name" value="VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07474">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00058">
        <property type="entry name" value="Ldl_recept_b"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00086">
        <property type="entry name" value="Thyroglobulin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00682">
        <property type="entry name" value="G2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00539">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00211">
        <property type="entry name" value="TY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54511">
        <property type="entry name" value="GFP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57610">
        <property type="entry name" value="Thyroglobulin type-1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51120">
        <property type="entry name" value="LDLRB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51220">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50993">
        <property type="entry name" value="NIDOGEN_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00484">
        <property type="entry name" value="THYROGLOBULIN_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51162">
        <property type="entry name" value="THYROGLOBULIN_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0084">Basement membrane</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0765">Sulfation</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133361" description="Nidogen-1" evidence="21">
        <location>
            <begin position="31"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="25">
        <location>
            <begin position="106"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Nidogen G2 beta-barrel" evidence="23">
        <location>
            <begin position="442"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="680"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="722"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="770"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="814"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="Thyroglobulin type-1" evidence="24">
        <location>
            <begin position="858"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1002"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1045"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="repeat" description="LDL-receptor class B" evidence="18">
        <location>
            <begin position="1088"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="901"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1259" mass="137144" checksum="4084CB366C559463" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EMU6</accession>
    <name>A0A8B7EMU6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">ATP-binding cassette sub-family B member 6</fullName>
            <ecNumber evidence="30">7.6.2.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="32">ABC-type heme transporter ABCB6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="44" type="primary">ABCB6</name>
    </gene>
    <organism evidence="44 45">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="44" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="44" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="44" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="40">
            <text>coproporphyrin I(in) + ATP + H2O = coproporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66768"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167478"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="40">
            <dbReference type="Rhea" id="RHEA:66769"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:131725"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:66665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:66681"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>heme b(in) + ATP + H2O = heme b(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:19262"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61360"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58687"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:61361"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61336"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:61337"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>uroporphyrin I(in) + ATP + H2O = uroporphyrin I(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167480"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:66773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>uroporphyrin III(in) + ATP + H2O = uroporphyrin III(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66776"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167479"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:66777"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
            <location evidence="2">Multivesicular body membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Golgi apparatus membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Lysosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Melanosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="29">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.5" evidence="30"/>
    <dbReference type="EMBL" id="ABDC03010755">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595646.1">
        <property type="nucleotide sequence ID" value="XM_012740192.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EMU6"/>
    <dbReference type="Ensembl" id="ENSMICT00000000780.3">
        <property type="protein sequence ID" value="ENSMICP00000000701.2"/>
        <property type="gene ID" value="ENSMICG00000000778.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857670"/>
    <dbReference type="KEGG" id="mmur:105857670"/>
    <dbReference type="CTD" id="10058"/>
    <dbReference type="GeneTree" id="ENSGT00940000156160"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="12">Serine/threonine/tyrosine kinase 1</fullName>
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        <name evidence="16" type="primary">STYK1</name>
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    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03010329">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596930.1">
        <property type="nucleotide sequence ID" value="XM_012741476.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596931.1">
        <property type="nucleotide sequence ID" value="XM_012741477.2"/>
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    <dbReference type="RefSeq" id="XP_012596932.1">
        <property type="nucleotide sequence ID" value="XM_012741478.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596933.1">
        <property type="nucleotide sequence ID" value="XM_012741479.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596935.1">
        <property type="nucleotide sequence ID" value="XM_012741481.2"/>
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    <dbReference type="RefSeq" id="XP_012596936.1">
        <property type="nucleotide sequence ID" value="XM_012741482.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7EPN8"/>
    <dbReference type="Ensembl" id="ENSMICT00000068836.1">
        <property type="protein sequence ID" value="ENSMICP00000047276.1"/>
        <property type="gene ID" value="ENSMICG00000042466.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105858378"/>
    <dbReference type="KEGG" id="mmur:105858378"/>
    <dbReference type="CTD" id="55359"/>
    <dbReference type="GeneTree" id="ENSGT00940000157871"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Serine/threonine/tyrosine kinase 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.510.10:FF:000450">
        <property type="entry name" value="Tyrosine-protein kinase STYK1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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    <dbReference type="InterPro" id="IPR050122">
        <property type="entry name" value="RTK"/>
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    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416:SF631">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24416">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="119"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011903"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022777"/>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023137"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00069128"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00077455"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077789"/>
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    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="Ensembl" id="ENSMICP00000047276.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
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            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="427" mass="47846" checksum="234F0EE353C78036" modified="2022-01-19" version="1">MGGEKGMTRVLLECSLTDKLCVVQEKQYEVIIVPALLVGTFLILLGVILWLFIREQRAQQQQPGLRGTAPIPPSRDLSWEAAGHGGNVVVPLKETSVESFLQTTAPALAKLQVPREQLSEVLEQIYNGSCGAIYRAKMNTGDSAKPKTVVLKALKEPAELHEVQDFLGRIQFYQYLGKHKNLVQLEGCCTESLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLSALEFLQDKHLFHGDVAARNILIQSDLTAKLCGLGLAYEVHAQGAISSTRTIPLKWLAPERLLLRPAGIRGDVWSFGILLYEMVTLGAPPYPEVPPTSILQYLQRRKIMKRPSSCTHTMYSIMKSCWRWSEDNRPLPRELRLRLEAATRTADDKAVLQVPELVVPELYAAVAGIRVESLSYSYSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EWA9</accession>
    <name>A0A8B7EWA9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Growth factor independent 1B transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GFI1B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03014966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599597.1">
        <property type="nucleotide sequence ID" value="XM_012744143.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599598.1">
        <property type="nucleotide sequence ID" value="XM_012744144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EWA9"/>
    <dbReference type="Ensembl" id="ENSMICT00000060786.1">
        <property type="protein sequence ID" value="ENSMICP00000045826.1"/>
        <property type="gene ID" value="ENSMICG00000010656.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859886"/>
    <dbReference type="KEGG" id="mmur:105859886"/>
    <dbReference type="CTD" id="8328"/>
    <dbReference type="GeneTree" id="ENSGT00940000160010"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000148">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000245">
        <property type="entry name" value="zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000489">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000827">
        <property type="entry name" value="Zinc finger protein Gfi-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000208">
        <property type="entry name" value="zinc finger protein Gfi-1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="65"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="328" mass="36916" checksum="954112A339A01BC2" modified="2022-01-19" version="1">MPRSFLVKSKKAHTYHQPRVPEDGPLWPPALPPEARDQVLGSGPVLSTMFPSRCLDWPNLKLEPEQDQSLARAASAPEVPTVMSRPQDGDSPLSDSPPFYKPSISWDTLASSYGHGYRQAPSTMQSAFLERSVSLYGSPLVPSAEPPLDFALRYSPGLEAYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EYE1</accession>
    <name>A0A8B7EYE1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PAK1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03006536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600443.1">
        <property type="nucleotide sequence ID" value="XM_012744989.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600444.1">
        <property type="nucleotide sequence ID" value="XM_012744990.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600446.1">
        <property type="nucleotide sequence ID" value="XM_012744992.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600447.1">
        <property type="nucleotide sequence ID" value="XM_012744993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600448.1">
        <property type="nucleotide sequence ID" value="XM_012744994.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142223.1">
        <property type="nucleotide sequence ID" value="XM_020286634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EYE1"/>
    <dbReference type="Ensembl" id="ENSMICT00000032917.2">
        <property type="protein sequence ID" value="ENSMICP00000028404.2"/>
        <property type="gene ID" value="ENSMICG00000015365.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860338"/>
    <dbReference type="KEGG" id="mmur:105860338"/>
    <dbReference type="CTD" id="5058"/>
    <dbReference type="GeneTree" id="ENSGT00950000182988"/>
    <dbReference type="OrthoDB" id="2914378at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048754">
        <property type="term" value="P:branching morphogenesis of an epithelial tube"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0048012">
        <property type="term" value="P:hepatocyte growth factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060244">
        <property type="term" value="P:negative regulation of cell proliferation involved in contact inhibition"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030335">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="term" value="P:positive regulation of intracellular estrogen receptor signaling pathway"/>
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    <dbReference type="GO" id="GO:0090063">
        <property type="term" value="P:positive regulation of microtubule nucleation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051496">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903608">
        <property type="term" value="P:protein localization to cytoplasmic stress granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002223">
        <property type="term" value="P:stimulatory C-type lectin receptor signaling pathway"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042060">
        <property type="term" value="P:wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06654">
        <property type="entry name" value="STKc_PAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000001">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF10">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="13">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="269"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="212"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028404.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="544" mass="60605" checksum="C2DD3F30FA616E8B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2M5</accession>
    <name>A0A8B7F2M5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105861304</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602148.1">
        <property type="nucleotide sequence ID" value="XM_012746694.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F2M5"/>
    <dbReference type="Ensembl" id="ENSMICT00000065247.1">
        <property type="protein sequence ID" value="ENSMICP00000040757.1"/>
        <property type="gene ID" value="ENSMICG00000044406.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105861304"/>
    <dbReference type="KEGG" id="mmur:105861304"/>
    <dbReference type="GeneTree" id="ENSGT01140000282514"/>
    <dbReference type="OrthoDB" id="9448403at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15410">
        <property type="entry name" value="7tmA_OR5D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="34390" checksum="BA4C54A57340D3DF" modified="2022-01-19" version="1">MGKGNCSTVTEFILLGLSDAPELRAFLPLMFLLIYGVTVLANLGMTALIHVSSGLHTPMYFFLSHLSFIDFCYSSIIVPKMLANILNKDKSISFLGCMMQFYLFCTCVVTEVFLLAVMAYDRFVAICTPLLYMVTMSQKLCVGLVSCCYFCGTLCSLIHLCLALEIPSYRSNVINHFFCDLPPLLSLACSDVTVNEVLLFIVASFNEISTIVIILTSYLFIVITILRMRSAEGRCKAFSTCASHLTAIVVFHGTILSIYCRPSSGTSGDADKVATVFYTVVIPMLNPLIYSLRNKDVKEALRKVLGSKIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F334</accession>
    <name>A0A8B7F334_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RAB31, member RAS onco family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RAB31</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023072">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023073">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601629.1">
        <property type="nucleotide sequence ID" value="XM_012746175.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F334"/>
    <dbReference type="Ensembl" id="ENSMICT00000002879.3">
        <property type="protein sequence ID" value="ENSMICP00000002622.2"/>
        <property type="gene ID" value="ENSMICG00000002882.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860983"/>
    <dbReference type="KEGG" id="mmur:105860983"/>
    <dbReference type="CTD" id="11031"/>
    <dbReference type="GeneTree" id="ENSGT00940000155702"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036186">
        <property type="term" value="C:early phagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001891">
        <property type="term" value="C:phagocytic cup"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090382">
        <property type="term" value="P:phagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060100">
        <property type="term" value="P:positive regulation of phagocytosis, engulfment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000346">
        <property type="entry name" value="RAB31, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002622.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="195" mass="21491" checksum="FA06DD90EDA7B876" modified="2022-01-19" version="1">MMAIRELKVCLLGDTGVGKSSIVCRFVQDHFDHNISPTIGASFMTKTVPCGNELHKFLIWDTAGQERFHSLAPMYYRGSAAAVIVYDITKQDSFHTLKKWVKELKEHGPENIVMAIAGNKCDLSDIREVPLKDAKEYAESIGAIVVETSAKNAINIEELFQGISRQIPPLDPLENGNSGTIKLGKPGTQASRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F9A9</accession>
    <name>A0A8B7F9A9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 16">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">COPA</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with SCYL1. Interacts with JAGN1. Interacts with TMEM41B. Interacts with SVEP1. Probably interacts with PEX11A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus membrane</location>
            <topology evidence="1 16">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003100">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604608.1">
        <property type="nucleotide sequence ID" value="XM_012749154.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F9A9"/>
    <dbReference type="Ensembl" id="ENSMICT00000013989.3">
        <property type="protein sequence ID" value="ENSMICP00000012753.3"/>
        <property type="gene ID" value="ENSMICG00000013972.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862676"/>
    <dbReference type="KEGG" id="mmur:105862676"/>
    <dbReference type="CTD" id="1314"/>
    <dbReference type="GeneTree" id="ENSGT00940000155451"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030157">
        <property type="term" value="P:pancreatic juice secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099612">
        <property type="term" value="P:protein localization to axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902463">
        <property type="term" value="P:protein localization to cell leading edge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <keyword evidence="5 17" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="245"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="18">
        <location>
            <begin position="341"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="20">
        <location>
            <begin position="610"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="19">
        <location>
            <begin position="815"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012753.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1224" mass="138318" checksum="FBFC46342C0A7A8B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FUL9</accession>
    <name>A0A8B7FUL9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox protein DLX-6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DLX6</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the distal-less homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015495">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612595.1">
        <property type="nucleotide sequence ID" value="XM_012757141.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612596.1">
        <property type="nucleotide sequence ID" value="XM_012757142.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FUL9"/>
    <dbReference type="Ensembl" id="ENSMICT00000034203.2">
        <property type="protein sequence ID" value="ENSMICP00000032293.1"/>
        <property type="gene ID" value="ENSMICG00000014432.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867276"/>
    <dbReference type="KEGG" id="mmur:105867276"/>
    <dbReference type="CTD" id="1750"/>
    <dbReference type="GeneTree" id="ENSGT00940000157683"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
        <property type="term" value="P:anatomical structure formation involved in morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060322">
        <property type="term" value="P:head development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042472">
        <property type="term" value="P:inner ear morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050679">
        <property type="term" value="P:positive regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000468">
        <property type="entry name" value="Distal-less homeobox 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF26">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="161"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="7">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="289" mass="32039" checksum="6AB149F90FA5E9C3" modified="2022-01-19" version="1">MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQPPPPPPPPPQPHSQQSSPAMAGAHYPLHCLHSAAAAAAAGSHHHHHHQHHHHGSPYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLPGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FUM0</accession>
    <name>A0A8B7FUM0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KLC2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Oligomeric complex composed of two heavy chains and two light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the kinesin light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006017">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612927.1">
        <property type="nucleotide sequence ID" value="XM_012757473.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612929.1">
        <property type="nucleotide sequence ID" value="XM_012757475.3"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="term" value="C:plasma membrane"/>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:lysosome localization"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000003">
        <property type="entry name" value="kinesin light chain isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="Kinesin_light"/>
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        <property type="entry name" value="Kinesin_light_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783">
        <property type="entry name" value="KINESIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45783:SF2">
        <property type="entry name" value="KINESIN LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01160">
        <property type="entry name" value="KINESIN_LIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="282"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="496"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="559"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="85"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
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        <source>
            <dbReference type="RuleBase" id="RU367020"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007844.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="622" mass="68570" checksum="47893CD821D63D95" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G6J7</accession>
    <name>A0A8B7G6J7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PPIF</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.</text>
    </comment>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with the mitochondrial membrane ATP synthase F(1)F(0) ATP synthase; the association is increased by inorganic phosphate (Pi) and decreased by cyclosporin A (CsA). Interacts with ATP5F1B; ATP5PD and ATP5PO. Interacts with SLC25A3; the interaction is impaired by CsA. Interacts with BCL2; the interaction is impaired by CsA. Interacts with TP53; the association implicates preferentially tetrameric TP53, is induced by oxidative stress and is impaired by CsA. Interacts with C1QBP. Interacts with MCUR1. Component of the mitochondrial permeability transition pore complex (mPTPC), at least composed of SPG7, VDAC1 and PPIF. Interacts with SPG7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03018968">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617926.1">
        <property type="nucleotide sequence ID" value="XM_012762472.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G6J7"/>
    <dbReference type="Ensembl" id="ENSMICT00000007081.3">
        <property type="protein sequence ID" value="ENSMICP00000006450.1"/>
        <property type="gene ID" value="ENSMICG00000007086.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870127"/>
    <dbReference type="KEGG" id="mmur:105870127"/>
    <dbReference type="CTD" id="10105"/>
    <dbReference type="GeneTree" id="ENSGT00940000156008"/>
    <dbReference type="OMA" id="FKSIVPR"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005757">
        <property type="term" value="C:mitochondrial permeability transition pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008637">
        <property type="term" value="P:apoptotic mitochondrial changes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071243">
        <property type="term" value="P:cellular response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051882">
        <property type="term" value="P:mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902686">
        <property type="term" value="P:mitochondrial outer membrane permeabilization involved in programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070266">
        <property type="term" value="P:necroptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090201">
        <property type="term" value="P:negative regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902445">
        <property type="term" value="P:regulation of mitochondrial membrane permeability involved in programmed necrotic cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002931">
        <property type="term" value="P:response to ischemia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098528">
        <property type="term" value="P:skeletal muscle fiber differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF408">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1210">Necrosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="49"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00056702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="207" mass="21890" checksum="489E6EA733B68E56" modified="2022-01-19" version="1">MLALRCGPRLLGLFPGPRSAPLRLSAARACSGGGARNPSSSSAGNPLVYLDVGADGQPLGRVVLELKADVVPKTAENFRALCTGEKGFGYKGSTFHRVIPSFMCQAGDFTNHNGTGGRSIYGSRFPDENFTLKHVGPGILSMANAGPNTNGSQFFICTVKTEWLDGKHVVFGHVKEGMDVVKKIESFGSKNGKTSKKIVITDCGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G7D8</accession>
    <name>A0A8B7G7D8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calsyntenin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">CLSTN2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the calsyntenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000672">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000673">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617746.1">
        <property type="nucleotide sequence ID" value="XM_012762292.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G7D8"/>
    <dbReference type="Ensembl" id="ENSMICT00000072608.1">
        <property type="protein sequence ID" value="ENSMICP00000051809.1"/>
        <property type="gene ID" value="ENSMICG00000049019.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870034"/>
    <dbReference type="KEGG" id="mmur:105870034"/>
    <dbReference type="CTD" id="64084"/>
    <dbReference type="GeneTree" id="ENSGT00950000183086"/>
    <dbReference type="OMA" id="HMVIQPQ"/>
    <dbReference type="OrthoDB" id="10012272at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050806">
        <property type="term" value="P:positive regulation of synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000025">
        <property type="entry name" value="Calsyntenin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000029">
        <property type="entry name" value="Calsyntenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000062">
        <property type="entry name" value="Calsyntenin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045588">
        <property type="entry name" value="CLSTN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139">
        <property type="entry name" value="CALSYNTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14139:SF3">
        <property type="entry name" value="CALSYNTENIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19699">
        <property type="entry name" value="CLSTN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 22" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 25" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133781" description="Calsyntenin-2" evidence="25">
        <location>
            <begin position="23"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="26">
        <location>
            <begin position="44"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="26">
        <location>
            <begin position="161"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="884"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00059096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00069677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="957" mass="107015" checksum="35D962349ADE4DD3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8Y4</accession>
    <name>A0A8B7G8Y4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Steroidogenic acute regulatory protein, mitochondrial</fullName>
            <shortName evidence="12">StAR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">START domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">STAR</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">May interact with TSPO.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03023932">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618421.1">
        <property type="nucleotide sequence ID" value="XM_012762967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8Y4"/>
    <dbReference type="Ensembl" id="ENSMICT00000014670.3">
        <property type="protein sequence ID" value="ENSMICP00000013373.2"/>
        <property type="gene ID" value="ENSMICG00000014671.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870391"/>
    <dbReference type="KEGG" id="mmur:105870391"/>
    <dbReference type="CTD" id="6770"/>
    <dbReference type="GeneTree" id="ENSGT00940000155477"/>
    <dbReference type="OrthoDB" id="74575at2759"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015485">
        <property type="term" value="F:cholesterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120020">
        <property type="term" value="F:cholesterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008211">
        <property type="term" value="P:glucocorticoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032367">
        <property type="term" value="P:intracellular cholesterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070859">
        <property type="term" value="P:positive regulation of bile acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08905">
        <property type="entry name" value="START_STARD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000015">
        <property type="entry name" value="Steroidogenic acute regulatory protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029866">
        <property type="entry name" value="StAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000799">
        <property type="entry name" value="StAR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46489:SF1">
        <property type="entry name" value="STEROIDOGENIC ACUTE REGULATORY PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00978">
        <property type="entry name" value="STARPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00234">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="8 12" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0755">Steroidogenesis</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="START" evidence="13">
        <location>
            <begin position="67"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013373.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="285" mass="31748" checksum="9E36B4C5909D8344" modified="2022-01-19" version="1">MLLATFKLCAGSSYRHVRNMKGLRQQAVLAIGQELNRRALGGPSPGTWINQVRRRSSLLGSRLEETLYSDQELAYLRQGEEAMQTALDILGNQEGWKKETQQANGDKVLSKVVPDVGKVFRLEVVVDQPVERLYEELVDRMETMGEWNPNVKEIKVLQKIGKDTVITHELAAEAAGNLVGPRDFVSVRCAKRRGSTCVLAGMATQFGKMPEQKGVIRAEHGPTCMVLRPLAGSPSKTKLTWLLSIDLKGWLPKTIINQVLSQTQVDFANHLRKHLESSPAHEARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GAS4</accession>
    <name>A0A8B7GAS4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein 629</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ZNF629</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619643.2">
        <property type="nucleotide sequence ID" value="XM_012764189.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619644.2">
        <property type="nucleotide sequence ID" value="XM_012764190.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619645.2">
        <property type="nucleotide sequence ID" value="XM_012764191.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619646.2">
        <property type="nucleotide sequence ID" value="XM_012764192.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619647.2">
        <property type="nucleotide sequence ID" value="XM_012764193.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619648.2">
        <property type="nucleotide sequence ID" value="XM_012764194.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619649.2">
        <property type="nucleotide sequence ID" value="XM_012764195.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619650.2">
        <property type="nucleotide sequence ID" value="XM_012764196.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GAS4"/>
    <dbReference type="Ensembl" id="ENSMICT00000068900.1">
        <property type="protein sequence ID" value="ENSMICP00000043908.1"/>
        <property type="gene ID" value="ENSMICG00000042110.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105871063"/>
    <dbReference type="CTD" id="23361"/>
    <dbReference type="GeneTree" id="ENSGT00940000161909"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002063">
        <property type="entry name" value="RB associated KRAB zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001767">
        <property type="entry name" value="Zinc finger protein 629"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001960">
        <property type="entry name" value="zinc finger protein 629 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000431">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000520">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000751">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000990">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001090">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001188">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001198">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001202">
        <property type="entry name" value="zinc finger protein 629 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF142">
        <property type="entry name" value="ZINC FINGER PROTEIN 384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="19"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="346"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="374"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="486"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="662"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="842"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="603"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="788"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="788"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="869" mass="96322" checksum="924A015297B32B90" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GDD8</accession>
    <name>A0A8B7GDD8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">tRNA pseudouridine synthase Pus10</fullName>
            <ecNumber evidence="5">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Coiled-coil domain-containing protein 139</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">tRNA pseudouridine 55 synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PUS10</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. Does not show tRNA pseudouridylate synthase activity in the nucleus. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(54) in tRNA = pseudouridine(54) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:57876"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14141"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:57877"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:42533"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with components of the microprocessor complex DROSHA and DGCR8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03005043">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620286.1">
        <property type="nucleotide sequence ID" value="XM_012764832.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620287.1">
        <property type="nucleotide sequence ID" value="XM_012764833.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620288.1">
        <property type="nucleotide sequence ID" value="XM_012764834.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620289.1">
        <property type="nucleotide sequence ID" value="XM_012764835.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620290.1">
        <property type="nucleotide sequence ID" value="XM_012764836.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620291.1">
        <property type="nucleotide sequence ID" value="XM_012764837.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620292.1">
        <property type="nucleotide sequence ID" value="XM_012764838.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620294.1">
        <property type="nucleotide sequence ID" value="XM_012764840.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620295.1">
        <property type="nucleotide sequence ID" value="XM_012764841.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620296.1">
        <property type="nucleotide sequence ID" value="XM_012764842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GDD8"/>
    <dbReference type="SMR" id="A0A8B7GDD8"/>
    <dbReference type="Ensembl" id="ENSMICT00000010073.3">
        <property type="protein sequence ID" value="ENSMICP00000009175.2"/>
        <property type="gene ID" value="ENSMICG00000010073.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871480"/>
    <dbReference type="KEGG" id="mmur:105871480"/>
    <dbReference type="CTD" id="150962"/>
    <dbReference type="GeneTree" id="ENSGT00390000007529"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070878">
        <property type="term" value="F:primary miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2050:FF:000001">
        <property type="entry name" value="putative tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2510:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048742">
        <property type="entry name" value="Pus10_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21237">
        <property type="entry name" value="Pus10_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pus10 N-terminal eukaryotes" evidence="23">
        <location>
            <begin position="109"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="24">
        <location>
            <begin position="289"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00079393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00083669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009175.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="529" mass="60397" checksum="561B4F134C8BC385" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKN8</accession>
    <name>A0A8B7GKN8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein S100</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">S100 calcium-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">S100A11</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Facilitates the differentiation and the cornification of keratinocytes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the S-100 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002947">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623085.1">
        <property type="nucleotide sequence ID" value="XM_012767631.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKN8"/>
    <dbReference type="Ensembl" id="ENSMICT00000030318.2">
        <property type="protein sequence ID" value="ENSMICP00000028257.1"/>
        <property type="gene ID" value="ENSMICG00000034130.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873056"/>
    <dbReference type="KEGG" id="mmur:105873056"/>
    <dbReference type="CTD" id="6282"/>
    <dbReference type="GeneTree" id="ENSGT00940000154172"/>
    <dbReference type="OrthoDB" id="9451669at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014911">
        <property type="term" value="P:positive regulation of smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05023">
        <property type="entry name" value="S-100A11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000188">
        <property type="entry name" value="Protein S100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001751">
        <property type="entry name" value="S100/CaBP7/8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013787">
        <property type="entry name" value="S100_Ca-bd_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028482">
        <property type="entry name" value="S100A11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639:SF60">
        <property type="entry name" value="PROTEIN S100-A11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11639">
        <property type="entry name" value="S100 CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01023">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01394">
        <property type="entry name" value="S_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00303">
        <property type="entry name" value="S100_CABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="105" mass="11752" checksum="E50BEE79943124CF" modified="2022-01-19" version="1">MAKISSPTETERCIESLIAVFQKYSGKDGFNCTLSKTEFLSFMNTELAAFTKNQKDPGVLDRMMKKLDLNCDGQLDFQEFLNLIGGIAVACHDSFLKAAHPQKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKX8</accession>
    <name>A0A8B7GKX8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NK2 homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">NKX2-3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NK-2 homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019354">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623660.1">
        <property type="nucleotide sequence ID" value="XM_012768206.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKX8"/>
    <dbReference type="Ensembl" id="ENSMICT00000030988.2">
        <property type="protein sequence ID" value="ENSMICP00000036407.1"/>
        <property type="gene ID" value="ENSMICG00000002913.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873353"/>
    <dbReference type="KEGG" id="mmur:105873353"/>
    <dbReference type="CTD" id="159296"/>
    <dbReference type="GeneTree" id="ENSGT00940000157556"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043367">
        <property type="term" value="P:CD4-positive, alpha-beta T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022612">
        <property type="term" value="P:gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001776">
        <property type="term" value="P:leukocyte homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048535">
        <property type="term" value="P:lymph node development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030225">
        <property type="term" value="P:macrophage differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042475">
        <property type="term" value="P:odontogenesis of dentin-containing tooth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048541">
        <property type="term" value="P:Peyer's patch development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002317">
        <property type="term" value="P:plasma cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048621">
        <property type="term" value="P:post-embryonic digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050678">
        <property type="term" value="P:regulation of epithelial cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046541">
        <property type="term" value="P:saliva secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000078">
        <property type="entry name" value="NK2 homeobox 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050394">
        <property type="entry name" value="Homeobox_NK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24340:SF32">
        <property type="entry name" value="HOMEOBOX PROTEIN NKX-2.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="148"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="361" mass="38251" checksum="0C253B9DDED92956" modified="2022-01-19" version="1">MMLPSPVTSTPFSVKDILNLEQQQQHFHGAHLQADLEHHFHSAPCMLAAAEGTQFSDGGEEDEEEEGEKLSYLNSLTATDGHGDSGLCPQSYVHTVLRDSCSRPKEHEEEPEVVRDRSQKSCQLKKPLEAAGDCKAAEESERPKPRSRRKPRVLFSQAQVFELERRFKQQRYLSAPEREHLASSLKLTSTQVKIWFQNRRYKCKRQRQDKSLELGAHAAPPPPRRVAVPVLVRDGKPCVTPSAQAYGAPYSVGASAYSYNSFPAYGYGNSAAAAAAAAAAAAAYSGSYGCAYPAGGGSGGTGASAATTTMQPACSAAGGGPFVNVSNLGGFGGGGGAQPLHQGAAVGAACAQGTLQGIRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GNV6</accession>
    <name>A0A8B7GNV6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Krueppel-like factor 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KLF7</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with FBXO38.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624580.1">
        <property type="nucleotide sequence ID" value="XM_012769126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GNV6"/>
    <dbReference type="Ensembl" id="ENSMICT00000037589.2">
        <property type="protein sequence ID" value="ENSMICP00000025661.1"/>
        <property type="gene ID" value="ENSMICG00000037405.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000059304.1">
        <property type="protein sequence ID" value="ENSMICP00000047180.1"/>
        <property type="gene ID" value="ENSMICG00000037405.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873832"/>
    <dbReference type="KEGG" id="mmur:105873832"/>
    <dbReference type="CTD" id="8609"/>
    <dbReference type="GeneTree" id="ENSGT00940000155235"/>
    <dbReference type="OrthoDB" id="4748970at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048813">
        <property type="term" value="P:dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904178">
        <property type="term" value="P:negative regulation of adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061179">
        <property type="term" value="P:negative regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045604">
        <property type="term" value="P:regulation of epidermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21585">
        <property type="entry name" value="KLF7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000021">
        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001395">
        <property type="entry name" value="Krueppel-like factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000624">
        <property type="entry name" value="zinc finger protein 697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF77">
        <property type="entry name" value="KRUEPPEL-LIKE FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="219"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="302" mass="33408" checksum="3BC7D4BB833A1A48" modified="2022-01-19" version="1">MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEATICEKSSAVDILLSRDKLLSETCLSLQPTSSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGGVATAAAAVAAAGTVKSGQSDSDQGGLGADACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GP30</accession>
    <name>A0A8B7GP30_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase TRIM71</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein lin-41 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">RING-type E3 ubiquitin transferase TRIM71</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Tripartite motif-containing protein 71</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">TRIM71</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Interacts (via NHL repeats) with AGO2; the interaction increases in presence of RNA. Interacts with HSP90AA1. Interacts (via NHL repeats) with MOV10, PABPC1, PUM1, PUM2, STAU2, XRN1 and XRN2 in an RNA-dependent manner. Interacts with SHCBP1; leading to enhance its stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03000257">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000258">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000262">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624671.1">
        <property type="nucleotide sequence ID" value="XM_012769217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GP30"/>
    <dbReference type="Ensembl" id="ENSMICT00000072951.1">
        <property type="protein sequence ID" value="ENSMICP00000051611.1"/>
        <property type="gene ID" value="ENSMICG00000049091.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873907"/>
    <dbReference type="KEGG" id="mmur:105873907"/>
    <dbReference type="CTD" id="131405"/>
    <dbReference type="GeneTree" id="ENSGT00940000159099"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030371">
        <property type="term" value="F:translation repressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061158">
        <property type="term" value="P:3'-UTR-mediated mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035196">
        <property type="term" value="P:miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000637">
        <property type="term" value="P:positive regulation of miRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000177">
        <property type="term" value="P:regulation of neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072089">
        <property type="term" value="P:stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19812">
        <property type="entry name" value="Bbox1_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19796">
        <property type="entry name" value="Bbox2_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14954">
        <property type="entry name" value="NHL_TRIM71_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16589">
        <property type="entry name" value="RING-HC_TRIM71_C-VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000013">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000025">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000080">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000527">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000923">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000398">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050952">
        <property type="entry name" value="TRIM-NHL_E3_ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24104:SF55">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM71"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Filamin"/>
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        <property type="entry name" value="NHL"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FILAMIN_REPEAT"/>
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        <location>
            <begin position="12"/>
            <end position="95"/>
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            <begin position="481"/>
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            <begin position="595"/>
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            <begin position="642"/>
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        <location>
            <begin position="689"/>
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            <begin position="26"/>
            <end position="49"/>
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    <feature type="region of interest" description="Disordered" evidence="28">
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            <begin position="127"/>
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            <begin position="396"/>
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            <begin position="26"/>
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            <begin position="147"/>
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            <begin position="165"/>
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            <begin position="177"/>
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            <dbReference type="PROSITE" id="PS50089"/>
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            <dbReference type="PROSITE" id="PS50119"/>
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        <source>
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    <sequence length="870" mass="93546" checksum="D12E11E1EA22DAD3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GPX1</accession>
    <name>A0A8B7GPX1_MICMU</name>
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        <submittedName>
            <fullName evidence="7">Interferon induced transmembrane protein 1</fullName>
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        <name evidence="7" type="primary">IFITM2</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000017541.1"/>
        <property type="gene ID" value="ENSMICG00000033480.2"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cellular response to interferon-beta"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of viral genome replication"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:response to interferon-alpha"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:response to type II interferon"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CD225/Dispanin_fam"/>
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    <dbReference type="InterPro" id="IPR051517">
        <property type="entry name" value="IFITM_antiviral_protein"/>
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    <dbReference type="PANTHER" id="PTHR13999">
        <property type="entry name" value="INTERFERON INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13999:SF4">
        <property type="entry name" value="INTERFERON-INDUCED TRANSMEMBRANE PROTEIN 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017541.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="133" mass="14344" checksum="EDD0D715FFE304AD" modified="2022-01-19" version="1">MSHTPQTFFTRAQAGLPPNYEVLKEEHEVAVLGTPHGPATSTSTVIHVHSDTAVPDHVVWSLFNTLFLNCCCLGFIAFAYSVKSRDRKMVGDLTGAQAYASTAKCLNVWALVLSILGTILIIVATVVSVQNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GQ39</accession>
    <name>A0A8B7GQ39_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SKA complex subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Spindle and kinetochore-associated protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SKA1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="18">Component of the SKA complex, composed of SKA1, SKA2 and SKA3. The SKA complex is a homodimer organized around a central W-shaped coiled-coil structure, formed by the interacting domains of SKA1, SKA2, and SKA3, each end of the 'W' is extended further by the C-terminal microtubule-binding domains of SKA1 and SKA3; the complex forms extended structures on microtubules. Interacts (via SXLP motif) with MAPRE1 (via C-terminus); the interaction is direct and stabilizes the kinetochore-microtubule attachment of the SKA1 complex. Interacts (via C-terminus) with protein phosphatase PP1 subunit PPP1CA; the interaction is direct and required for recruitment of PPP1CA to the kinetochore. Interacts with the NDC80 complex; the interaction is required to establish kinetochore-microtubule end-on attachments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SKA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625298.1">
        <property type="nucleotide sequence ID" value="XM_012769844.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625299.1">
        <property type="nucleotide sequence ID" value="XM_012769845.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GQ39"/>
    <dbReference type="Ensembl" id="ENSMICT00000033388.2">
        <property type="protein sequence ID" value="ENSMICP00000036595.1"/>
        <property type="gene ID" value="ENSMICG00000006429.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061152.1">
        <property type="protein sequence ID" value="ENSMICP00000043593.1"/>
        <property type="gene ID" value="ENSMICG00000006429.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874239"/>
    <dbReference type="KEGG" id="mmur:105874239"/>
    <dbReference type="CTD" id="220134"/>
    <dbReference type="GeneTree" id="ENSGT00390000011654"/>
    <dbReference type="OrthoDB" id="5962at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0170027">
        <property type="term" value="C:SKA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051656">
        <property type="term" value="P:establishment of organelle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140499">
        <property type="term" value="P:negative regulation of mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12958">
        <property type="entry name" value="SKA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1890:FF:000001">
        <property type="entry name" value="Spindle and kinetochore-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1890">
        <property type="entry name" value="Ska1 microtubule binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009829">
        <property type="entry name" value="SKA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042031">
        <property type="entry name" value="SKA1_MBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28573">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28573:SF1">
        <property type="entry name" value="SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07160">
        <property type="entry name" value="SKA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00064456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="254" mass="29240" checksum="663F18730A335FDC" modified="2022-01-19" version="1">MASDLEQLCSHVNEKIGNIKKTLSLRNCGQEPTLKTILNKTGDDIIIVNELLNKLELEIQYQEQMNSSLKELCESLEEDYKDVEHLEENIPSHLPPVTVTQSSVKGSDLDSEEPLKVVEPAPTKKPPKEQRSIKEIPFITCDEFNGIPAYMKSRLTYCKINEVIEEINKAVISKYKILHQPKKSMNSVARNLYHRFIDQETKDTKGHYFIVEADIKEFTTLKVDKKFHMLLNILRHCRRLSEVRGGGLTRYVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GQA7</accession>
    <name>A0A8B7GQA7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SYNPR</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptophysin/synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03032128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032129">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625379.1">
        <property type="nucleotide sequence ID" value="XM_012769925.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GQA7"/>
    <dbReference type="Ensembl" id="ENSMICT00000030232.2">
        <property type="protein sequence ID" value="ENSMICP00000021780.1"/>
        <property type="gene ID" value="ENSMICG00000016442.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874268"/>
    <dbReference type="CTD" id="132204"/>
    <dbReference type="GeneTree" id="ENSGT01030000234637"/>
    <dbReference type="OrthoDB" id="10006326at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 30"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001285">
        <property type="entry name" value="Synaptophysin/porin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306">
        <property type="entry name" value="SYNAPTOPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10306:SF16">
        <property type="entry name" value="SYNAPTOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00220">
        <property type="entry name" value="SYNAPTOPHYSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00604">
        <property type="entry name" value="SYNAPTOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133918" evidence="10">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="11">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="221"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="265" mass="29109" checksum="18EF917945997AF4" modified="2022-01-19" version="1">MCMVIFAPLFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQKLALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLWLVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFILWAGNIWFVFKETGWHSSGQRYLSDPMEKHSSSYTQGGYNQDSYGSSSGYGQQVSLGPSSDEFGQQPSGPTSFTNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GT31</accession>
    <name>A0A8B7GT31_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Neurobeachin-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NBEAL2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat neurobeachin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626524.1">
        <property type="nucleotide sequence ID" value="XM_012771070.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000017654.3">
        <property type="protein sequence ID" value="ENSMICP00000016077.3"/>
        <property type="gene ID" value="ENSMICG00000017654.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874893"/>
    <dbReference type="KEGG" id="mmur:105874893"/>
    <dbReference type="CTD" id="23218"/>
    <dbReference type="GeneTree" id="ENSGT00940000158454"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030220">
        <property type="term" value="P:platelet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001375">
        <property type="entry name" value="Neurobeachin-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046852">
        <property type="entry name" value="Neurobeachin_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF111">
        <property type="entry name" value="NEUROBEACHIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16057">
        <property type="entry name" value="DUF4800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20425">
        <property type="entry name" value="Neurobeachin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="11">
        <location>
            <begin position="1913"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="10">
        <location>
            <begin position="2051"/>
            <end position="2343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="2496"/>
            <end position="2529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="2547"/>
            <end position="2588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1299"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1365"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1303"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1365"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1389"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1427"/>
            <end position="1438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00068540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016077.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2752" mass="301718" checksum="1FA0850A3492253D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H0I7</accession>
    <name>A0A8B7H0I7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SLC6A3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Mediates sodium- and chloride-dependent transport of dopamine. Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-noradrenaline(out) + chloride(out) + Na(+)(out) = (R)-noradrenaline(in) + chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70923"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>dopamine(out) + chloride(out) + 2 Na(+)(out) = dopamine(in) + chloride(in) + 2 Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70931"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>dopamine(out) + chloride(out) + Na(+)(out) = dopamine(in) + chloride(in) + Na(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70919"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Axon</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016272">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016273">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629575.1">
        <property type="nucleotide sequence ID" value="XM_012774121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H0I7"/>
    <dbReference type="Ensembl" id="ENSMICT00000017612.3">
        <property type="protein sequence ID" value="ENSMICP00000016037.3"/>
        <property type="gene ID" value="ENSMICG00000017612.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876449"/>
    <dbReference type="CTD" id="6531"/>
    <dbReference type="GeneTree" id="ENSGT00940000161224"/>
    <dbReference type="OrthoDB" id="6581954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016600">
        <property type="term" value="C:flotillin complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035240">
        <property type="term" value="F:dopamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005330">
        <property type="term" value="F:dopamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005326">
        <property type="term" value="F:neurotransmitter transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021984">
        <property type="term" value="P:adenohypophysis development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990384">
        <property type="term" value="P:hyaloid vascular plexus regression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007595">
        <property type="term" value="P:lactation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:locomotory behavior"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001504">
        <property type="term" value="P:neurotransmitter uptake"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0040018">
        <property type="term" value="P:positive regulation of multicellular organism growth"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0060134">
        <property type="term" value="P:prepulse inhibition"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042053">
        <property type="term" value="P:regulation of dopamine metabolic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042220">
        <property type="term" value="P:response to cocaine"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000175">
        <property type="entry name" value="Na/ntran_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002436">
        <property type="entry name" value="Na/ntran_symport_dopamine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037272">
        <property type="entry name" value="SNS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037979">
        <property type="entry name" value="Na_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616:SF38">
        <property type="entry name" value="SODIUM-DEPENDENT DOPAMINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01202">
        <property type="entry name" value="DOPTRANSPORT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00176">
        <property type="entry name" value="NANEUSMPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00610">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="13 21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 20" id="KW-0915">Sodium</keyword>
    <keyword evidence="9 22" id="KW-0769">Symport</keyword>
    <keyword evidence="6 22 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="99"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="141"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="237"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="446"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="521"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="binding site" evidence="20">
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            <position position="75"/>
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        <ligand>
            <name>Na(+)</name>
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            <label>1</label>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR600175-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016037.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="619" mass="68596" checksum="9DC31255F622279E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H2D1</accession>
    <name>A0A8B7H2D1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zinc finger protein 382</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">KRAB/zinc finger suppressor protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Multiple zinc finger and krueppel-associated box protein KS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ZNF382</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Functions as a sequence-specific transcriptional repressor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with TRIM28; enhances the transcriptional repressor activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630363.1">
        <property type="nucleotide sequence ID" value="XM_012774909.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630364.1">
        <property type="nucleotide sequence ID" value="XM_012774910.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630365.1">
        <property type="nucleotide sequence ID" value="XM_012774911.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630366.1">
        <property type="nucleotide sequence ID" value="XM_012774912.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H2D1"/>
    <dbReference type="Ensembl" id="ENSMICT00000070522.1">
        <property type="protein sequence ID" value="ENSMICP00000048211.1"/>
        <property type="gene ID" value="ENSMICG00000037643.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876872"/>
    <dbReference type="KEGG" id="mmur:105876872"/>
    <dbReference type="CTD" id="84911"/>
    <dbReference type="GeneTree" id="ENSGT00940000162338"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000029">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000155">
        <property type="entry name" value="zinc finger protein 133 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002220">
        <property type="entry name" value="Zinc finger protein 382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000212">
        <property type="entry name" value="zinc finger protein 382 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001053">
        <property type="entry name" value="zinc finger protein 382 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000200">
        <property type="entry name" value="zinc finger protein 510 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000410">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF149">
        <property type="entry name" value="ZINC FINGER WITH KRAB AND SCAN DOMAINS 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="19">
        <location>
            <begin position="7"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="520"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="550" mass="63890" checksum="36118E558A3F8B83" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H2P7</accession>
    <name>A0A8B7H2P7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="15">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GAPDHS</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03026972">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630491.1">
        <property type="nucleotide sequence ID" value="XM_012775037.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H2P7"/>
    <dbReference type="Ensembl" id="ENSMICT00000010897.3">
        <property type="protein sequence ID" value="ENSMICP00000009928.3"/>
        <property type="gene ID" value="ENSMICG00000010889.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876925"/>
    <dbReference type="CTD" id="26330"/>
    <dbReference type="GeneTree" id="ENSGT00940000160272"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF79">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, TESTIS-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="17">
        <location>
            <begin position="64"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="271"/>
            <end position="272"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="13">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009928.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="396" mass="43029" checksum="21811B5EFDFE3B5C" modified="2022-01-19" version="1">MSKRDIVLTNVTVVQLLRQPCPVTRPPPPPEPRIEADCPPQPEPVREEGKPPSPPPKASPSRELTVGINGFGRIGRLVLRACMEKGIKVVAVNDPFIDPEYMVYMFKYDSTHGRYKGNVEHRNGKLVVDNQEIAVFQCKTPKEIPWKSVGNPYVVEATGVYLSLEAVSEHVSSGAQRVVICAPSPDAPTFVMGVNENSYDPGSMNVVSNASCTTNCLAPLAKVIHESFGIEEGLMTTVHAYTATQKTVDGPSKKAWRDGRGAHQNIIPASTGAAKAVGKVIPELKGKLTGMAFRVPTPDVSVVDLTCRLAKPASYSAIKDAVKAAAKGPMAGILAYTEDEVVSTDFVSDTHSSIFDAKAGIALNDNFVKLISWYDNEYGYSHRVVDLLRYMFSRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H5N8</accession>
    <name>A0A8B7H5N8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydropyrimidinase-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">DPYSL2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023693">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023694">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630803.1">
        <property type="nucleotide sequence ID" value="XM_012775349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H5N8"/>
    <dbReference type="Ensembl" id="ENSMICT00000052645.2">
        <property type="protein sequence ID" value="ENSMICP00000033159.1"/>
        <property type="gene ID" value="ENSMICG00000015794.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877120"/>
    <dbReference type="KEGG" id="mmur:105877120"/>
    <dbReference type="CTD" id="1808"/>
    <dbReference type="GeneTree" id="ENSGT01030000234527"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cytoskeleton organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:nervous system development"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of neuron projection development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.40.10:FF:000022">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Amidohydro-rel"/>
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        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
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        <property type="entry name" value="Metal_Hydrolase"/>
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    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF56">
        <property type="entry name" value="DIHYDROPYRIMIDINASE-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="169"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="617"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00025964"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF01979"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033159.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="677" mass="73639" checksum="3761F98F11E5A202" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBH2</accession>
    <name>A0A8B7HBH2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Calcium uptake protein 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">EF-hand domain-containing family member A1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MICU2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer; disulfide-linked; heterodimerizes with MICU1. Component of the uniplex complex, composed of MCU, EMRE/SMDT1, MICU1 and MICU2 in a 4:4:1:1 stoichiometry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MICU1 family. MICU2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634142.1">
        <property type="nucleotide sequence ID" value="XM_012778688.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HBH2"/>
    <dbReference type="Ensembl" id="ENSMICT00000006907.3">
        <property type="protein sequence ID" value="ENSMICP00000006293.2"/>
        <property type="gene ID" value="ENSMICG00000006910.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878872"/>
    <dbReference type="KEGG" id="mmur:105878872"/>
    <dbReference type="CTD" id="221154"/>
    <dbReference type="GeneTree" id="ENSGT00950000183079"/>
    <dbReference type="OrthoDB" id="5859791at2759"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061891">
        <property type="term" value="F:calcium ion sensor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051562">
        <property type="term" value="P:negative regulation of mitochondrial calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051561">
        <property type="term" value="P:positive regulation of mitochondrial calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16174">
        <property type="entry name" value="EFh_MICU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000149">
        <property type="entry name" value="Mitochondrial calcium uptake family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000211">
        <property type="entry name" value="Mitochondrial calcium uptake family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF3">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="360"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006293.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="432" mass="49101" checksum="7C0AEE929F0CB5F9" modified="2022-01-19" version="1">MAAAAGGGARLAVWGGRLRRGLAAGRRAVPSPGPLAAAVAGAALAGAAAAWHHSRVKVAAREGSLGVLAQKNADPGIIEKLSLRKQRFMQFSSLEHEGEYYMTPRDFLFSVMFEQVKRKTSVKKLTKKDIEDALGGIQTSGCGSTFFRDLGDKGLISYTEYLFLLTILTKPHSGFHVAFKMLDADGNEMIEKKEFFKLQKIISKQEDLLTVKTNETEYQEPTAKEPEIKTTLQIHFFGKRGERKLHYKQFRRFMENLQTEIQEMEFLQFSKGLSFMRKEDFAEWLLFFTNTDNKDIYWKNVREKLSAGESISLDEFKSFCHFTTHLEDFAIAMQMFNLAHRPVRLAEFKRAVKVATGQELSNNILDTVFKIFDLDGDECLSHAEFLGVLKNRMHRGLWVPQNPTVQDYWKCVKKESIKGVKEVWKQAGKGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HCY4</accession>
    <name>A0A8B7HCY4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myc box-dependent-interacting protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Amphiphysin II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Amphiphysin-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Bridging integrator 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">BIN1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <location evidence="16">Sarcolemma</location>
            <location evidence="16">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634703.1">
        <property type="nucleotide sequence ID" value="XM_012779249.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HCY4"/>
    <dbReference type="Ensembl" id="ENSMICT00000046865.2">
        <property type="protein sequence ID" value="ENSMICP00000027144.2"/>
        <property type="gene ID" value="ENSMICG00000005344.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879180"/>
    <dbReference type="CTD" id="274"/>
    <dbReference type="GeneTree" id="ENSGT00950000182882"/>
    <dbReference type="OrthoDB" id="446293at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048156">
        <property type="term" value="F:tau protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030100">
        <property type="term" value="P:regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07611">
        <property type="entry name" value="BAR_Amphiphysin_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12139">
        <property type="entry name" value="SH3_Bin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000013">
        <property type="entry name" value="Amphiphysin isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000029">
        <property type="entry name" value="myc box-dependent-interacting protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003005">
        <property type="entry name" value="Amphiphysin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035471">
        <property type="entry name" value="Amphiphysin-2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003023">
        <property type="entry name" value="Amphiphysin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514">
        <property type="entry name" value="AMPHIPHYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46514:SF4">
        <property type="entry name" value="MYC BOX-DEPENDENT-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01251">
        <property type="entry name" value="AMPHIPHYSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01253">
        <property type="entry name" value="AMPHIPHYSIN2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 21" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="25">
        <location>
            <begin position="29"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="24">
        <location>
            <begin position="521"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="280"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00077838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00082834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027144.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="594" mass="64659" checksum="04C10C1F0C14AAEE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HD97</accession>
    <name>A0A8B7HD97_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PFN1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with ACTB. Interacts with VASP. Interacts with HTT. Interacts with SH3BGRL. Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Interacts with ACTMAP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the profilin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020484">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634879.1">
        <property type="nucleotide sequence ID" value="XM_012779425.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HD97"/>
    <dbReference type="Ensembl" id="ENSMICT00000045654.2">
        <property type="protein sequence ID" value="ENSMICP00000034794.1"/>
        <property type="gene ID" value="ENSMICG00000030835.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879276"/>
    <dbReference type="KEGG" id="mmur:105879276"/>
    <dbReference type="CTD" id="5216"/>
    <dbReference type="GeneTree" id="ENSGT00940000153664"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032233">
        <property type="term" value="P:positive regulation of actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00148">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.30:FF:000008">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005454">
        <property type="entry name" value="Profilin1/2/3_vertebrate"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027310">
        <property type="entry name" value="Profilin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13936">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13936:SF14">
        <property type="entry name" value="PROFILIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01639">
        <property type="entry name" value="PROFILINMAML"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00414">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="140" mass="15038" checksum="6EFA2BCAAAA1E3FD" modified="2022-01-19" version="1">MAGWNAYIDNLMADGNCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFFVNGLTLGGQKCSVIRDSLLQDGEFTMDLRTKSTGGAPTFNITVTMTAKTLVLLMGKEGVHGGLINKKCYEMASHLRRSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HDK1</accession>
    <name>A0A8B7HDK1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">MEKK1-related protein X</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">ZZ-type zinc finger-containing protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Zinc finger SWIM domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ZSWIM2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer. Interacts with UBE2D1.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03010990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634931.1">
        <property type="nucleotide sequence ID" value="XM_012779477.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HDK1"/>
    <dbReference type="Ensembl" id="ENSMICT00000034949.2">
        <property type="protein sequence ID" value="ENSMICP00000019053.1"/>
        <property type="gene ID" value="ENSMICG00000030781.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879306"/>
    <dbReference type="KEGG" id="mmur:105879306"/>
    <dbReference type="CTD" id="151112"/>
    <dbReference type="GeneTree" id="ENSGT00390000006826"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902043">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16486">
        <property type="entry name" value="mRING-H2-C3H2C2D_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:001047">
        <property type="entry name" value="Zinc finger, SWIM domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039903">
        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZSWIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="20">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="147"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="19">
        <location>
            <begin position="230"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="636" mass="73158" checksum="82F36F19C11C1082" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HJ59</accession>
    <name>A0A8B7HJ59_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Integrin alpha-6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">CD49 antigen-like family member F</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Integrin alpha-7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">VLA-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">ITGA6</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 (ITGB1) or beta-4 (ITGB4) to form ITGA6:ITGB1 and ITGA6:ITGB4, respectively. ITGA6:ITGB1 is found in a complex with CD9; interaction takes place in oocytes and is involved in sperm-egg fusion. ITGA6:ITGB4 is found in a ternary complex with NRG1 and ERBB3. ITGA6:ITGB4 is found in a ternary complex with IGF1 and IGF1R. ITGA6:ITGB4 interacts with IGF2. Interacts with ADAM9. Interacts with RAB21. Interacts with MDK. ITGA6:ITGB1 interacts with MDK; this interaction mediates MDK-induced neurite outgrowth. Interacts with CD82; this interaction down-regulates ITGA6-mediated cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="29">Membrane</location>
            <topology evidence="29">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 29">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637398.1">
        <property type="nucleotide sequence ID" value="XM_012781944.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HJ59"/>
    <dbReference type="Ensembl" id="ENSMICT00000047196.2">
        <property type="protein sequence ID" value="ENSMICP00000037147.1"/>
        <property type="gene ID" value="ENSMICG00000006990.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880728"/>
    <dbReference type="CTD" id="3655"/>
    <dbReference type="GeneTree" id="ENSGT00940000155353"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008305">
        <property type="term" value="C:integrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000002">
        <property type="entry name" value="integrin alpha-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000002">
        <property type="entry name" value="integrin alpha-6 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000002">
        <property type="entry name" value="Integrin subunit alpha 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1530:FF:000001">
        <property type="entry name" value="Integrin subunit alpha 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF9">
        <property type="entry name" value="INTEGRIN ALPHA-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00357">
        <property type="entry name" value="Integrin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 29" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 29" id="KW-0401">Integrin</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0564">Palmitate</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19 29" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 29" id="KW-0732">Signal</keyword>
    <keyword evidence="7 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 29" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044038173" description="Integrin alpha-6" evidence="29">
        <location>
            <begin position="24"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="1012"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="28">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="28">
        <location>
            <begin position="101"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="28">
        <location>
            <begin position="301"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="28">
        <location>
            <begin position="364"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="28">
        <location>
            <begin position="418"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="30">
        <location>
            <begin position="464"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="31">
        <location>
            <begin position="626"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="32">
        <location>
            <begin position="796"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00054656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00062424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00068408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00068411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00079514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00080506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1072" mass="119275" checksum="967EEACFE3E986CD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HKN9</accession>
    <name>A0A8B7HKN9_MICMU</name>
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        <recommendedName>
            <fullName evidence="11">Retinoic acid receptor RXR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nuclear receptor subfamily 2 group B member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RXRA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer. Heterodimer; with a rar molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear hormone receptor family. NR2 subfamily.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637571.1">
        <property type="nucleotide sequence ID" value="XM_012782117.1"/>
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        <property type="nucleotide sequence ID" value="XM_012782118.1"/>
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        <property type="nucleotide sequence ID" value="XM_012782119.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7HKN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000010833.3">
        <property type="protein sequence ID" value="ENSMICP00000009870.3"/>
        <property type="gene ID" value="ENSMICG00000010833.3"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000159789"/>
    <dbReference type="OrthoDB" id="5873264at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003707">
        <property type="term" value="F:nuclear steroid receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="NR_DBD_RXR"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NR_LBD_RXR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
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        <property type="entry name" value="Retinoic acid receptor RXR-alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retinoid X Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NHR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021780">
        <property type="entry name" value="Nuc_recep-AF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000536">
        <property type="entry name" value="Nucl_hrmn_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050274">
        <property type="entry name" value="Nuclear_hormone_rcpt_NR2"/>
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        <property type="entry name" value="Nuclear_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000003">
        <property type="entry name" value="Retinoid-X_rcpt/HNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001628">
        <property type="entry name" value="Znf_hrmn_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24083">
        <property type="entry name" value="NUCLEAR HORMONE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00104">
        <property type="entry name" value="Hormone_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11825">
        <property type="entry name" value="Nuc_recep-AF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00105">
        <property type="entry name" value="zf-C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00545">
        <property type="entry name" value="RETINOIDXR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00398">
        <property type="entry name" value="STRDHORMONER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00047">
        <property type="entry name" value="STROIDFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00430">
        <property type="entry name" value="HOLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00399">
        <property type="entry name" value="ZnF_C4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="13">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="14">
        <location>
            <begin position="203"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006421"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
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            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009870.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="438" mass="47827" checksum="CB34B44B8965100D" modified="2022-01-19" version="1">MAAPSLHPALGPGIGSSLGSPGQLHSPISTLSSPINGMGPPFSVISSPMGHSMSVPTTPTLGFGTGSPQLSSPMNPASSSEDVKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKERSENEVESTSSASEDMPVEKILEAELAVEPKTGACVEANTGLHPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HKR7</accession>
    <name>A0A8B7HKR7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytoskeleton associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CKAP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CKAP2 family.</text>
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    <dbReference type="EMBL" id="ABDC03017706">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012782675.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7HKR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000006824.3">
        <property type="protein sequence ID" value="ENSMICP00000006218.2"/>
        <property type="gene ID" value="ENSMICG00000006824.3"/>
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    <dbReference type="CTD" id="26586"/>
    <dbReference type="GeneTree" id="ENSGT00530000063691"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:mitotic spindle"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:mitotic cytokinesis"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="CKAP2_fam"/>
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        <property type="entry name" value="CYTOSKELETON ASSOCIATED PROTEIN 2-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR16076:SF8">
        <property type="entry name" value="CYTOSKELETON-ASSOCIATED PROTEIN 2"/>
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    <dbReference type="Pfam" id="PF15297">
        <property type="entry name" value="CKAP2_C"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
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            <end position="705"/>
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009468"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF15297"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Belongs to the FAM53 family.</text>
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    <dbReference type="EMBL" id="ABDC03021798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HME6"/>
    <dbReference type="Ensembl" id="ENSMICT00000064260.1">
        <property type="protein sequence ID" value="ENSMICP00000046187.1"/>
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    <dbReference type="Ensembl" id="ENSMICT00000064664.1">
        <property type="protein sequence ID" value="ENSMICP00000049040.1"/>
        <property type="gene ID" value="ENSMICG00000044027.1"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:protein import into nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="FAM53"/>
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        <property type="entry name" value="PROTEIN FAM53A"/>
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    <dbReference type="PANTHER" id="PTHR28567">
        <property type="entry name" value="PROTEIN FAM53A-LIKE ISOFORM X1"/>
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    </dbReference>
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        <property type="entry name" value="FAM53"/>
        <property type="match status" value="1"/>
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        <location>
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            <end position="121"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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        <location>
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            <end position="328"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00010984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="398" mass="42610" checksum="1071B786B9EEC80A" modified="2022-01-19" version="1">MVTLITEKLQSQCLDDPTRKAEAGPYSAEKLNRSGHLFPLEISDQTPRKVLGGGWPVGSRVAAGHDLPFLPSLSGAAHTLGLQWQPESLGPHTGLGAVSAADLSESTGPPVAPPTKRHCRSLSEPEELARCRSLWRPSSSKVWTPVSKRRCNSGGSTTLQGIVGTVLPRNGVPLAGPTLPLAPRPSSASSGFVDSSESSSGSAPPWHLMGPCLLPLRRRLSLSQEHLMGTCTPLPSASSTPTSTPELGRRHGLLRCRSQPCVLSRRRSQRKRRHQEDARWTRPSLDFLKMTQTLKNSKSLCSLDCEDDDEGDAQVKTAVSSPSHSQGLTGILVAGSGPRVARPRPCPTSPRLWASREPVASEGVGRSSGDPSDWDSAGEEGVFPLEHGELDLEQIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRN7</accession>
    <name>A0A8B7HRN7_MICMU</name>
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        <submittedName>
            <fullName evidence="8">DAB adaptor protein 1</fullName>
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    </protein>
    <gene>
        <name evidence="8" type="primary">DAB1</name>
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    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001434">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001435">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640566.1">
        <property type="nucleotide sequence ID" value="XM_012785112.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640567.1">
        <property type="nucleotide sequence ID" value="XM_012785113.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRN7"/>
    <dbReference type="Ensembl" id="ENSMICT00000055096.2">
        <property type="protein sequence ID" value="ENSMICP00000025411.1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HU23</accession>
    <name>A0A8B7HU23_MICMU</name>
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        <recommendedName>
            <fullName evidence="2 18">Peroxisome proliferator-activated receptor gamma</fullName>
            <shortName evidence="18">PPAR-gamma</shortName>
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        <alternativeName>
            <fullName evidence="15 18">Nuclear receptor subfamily 1 group C member 3</fullName>
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    </protein>
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        <name type="scientific">Microcebus murinus</name>
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        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels.</text>
    </comment>
    <comment type="function">
        <text evidence="18">Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Heterodimer with other nuclear receptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 18">Belongs to the nuclear hormone receptor family. NR1 subfamily.</text>
    </comment>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48508">
        <property type="entry name" value="Nuclear receptor ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51843">
        <property type="entry name" value="NR_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00031">
        <property type="entry name" value="NUCLEAR_REC_DBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51030">
        <property type="entry name" value="NUCLEAR_REC_DBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0010">Activator</keyword>
    <keyword evidence="9 18" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="3 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 17" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 17" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nuclear receptor" evidence="19">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="NR LBD" evidence="20">
        <location>
            <begin position="238"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU364110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019295.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="505" mass="57414" checksum="8FFD801369DC3171" modified="2022-01-19" version="1">MGETLGDSPIDPESDSFTDILSASTSQEITMVDTEMPFWPTNFGISSVDLSMMDDHPHSFDIKPFTTVDFSSISSPHYEDIPYTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKSQLCSKPHEEPPSALVAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDSLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I5E4</accession>
    <name>A0A8B7I5E4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Intercellular adhesion molecule 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ICAM3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with moesin/MSN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. ICAM family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646117.1">
        <property type="nucleotide sequence ID" value="XM_012790663.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139573.1">
        <property type="nucleotide sequence ID" value="XM_020283984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I5E4"/>
    <dbReference type="Ensembl" id="ENSMICT00000010334.3">
        <property type="protein sequence ID" value="ENSMICP00000009413.3"/>
        <property type="gene ID" value="ENSMICG00000010335.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885594"/>
    <dbReference type="CTD" id="3385"/>
    <dbReference type="GeneTree" id="ENSGT00940000159005"/>
    <dbReference type="OrthoDB" id="6250964at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006909">
        <property type="term" value="P:phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00096">
        <property type="entry name" value="Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000194">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000459">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000648">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:002232">
        <property type="entry name" value="Intercellular adhesion molecule 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000338">
        <property type="entry name" value="intercellular adhesion molecule 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013162">
        <property type="entry name" value="CD80_C2-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003988">
        <property type="entry name" value="ICAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048679">
        <property type="entry name" value="ICAM1_3_5_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013768">
        <property type="entry name" value="ICAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047012">
        <property type="entry name" value="ICAM_VCAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003987">
        <property type="entry name" value="ICAM_VCAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771:SF17">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08205">
        <property type="entry name" value="C2-set_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21146">
        <property type="entry name" value="ICAM1_3_5_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03921">
        <property type="entry name" value="ICAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01473">
        <property type="entry name" value="ICAM"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01472">
        <property type="entry name" value="ICAMVCAM1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134248" description="Intercellular adhesion molecule 3" evidence="18">
        <location>
            <begin position="32"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="406"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009413.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="549" mass="59242" checksum="8FBC56F2754821D0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I9J6</accession>
    <name>A0A8B7I9J6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC6A14</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="8">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Weissenberger G."/>
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                <person name="Durand N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="term" value="F:neuropeptide hormone activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031781">
        <property type="term" value="F:type 3 melanocortin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031782">
        <property type="term" value="F:type 4 melanocortin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008343">
        <property type="term" value="P:adult feeding behavior"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044725">
        <property type="term" value="P:epigenetic programming in the zygotic pronuclei"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032438">
        <property type="term" value="P:melanosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032402">
        <property type="term" value="P:melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048023">
        <property type="term" value="P:positive regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.760.10">
        <property type="entry name" value="Agouti domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007733">
        <property type="entry name" value="Agouti"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027300">
        <property type="entry name" value="Agouti_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036836">
        <property type="entry name" value="Agouti_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16551">
        <property type="entry name" value="AGOUTI RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16551:SF1">
        <property type="entry name" value="AGOUTI-SIGNALING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05039">
        <property type="entry name" value="Agouti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00792">
        <property type="entry name" value="Agouti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57055">
        <property type="entry name" value="Agouti-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60024">
        <property type="entry name" value="AGOUTI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51150">
        <property type="entry name" value="AGOUTI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0960">Knottin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135493" description="Agouti-signaling protein" evidence="11">
        <location>
            <begin position="23"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Agouti" evidence="12">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="111"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017885"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00033432"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00494"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="132" mass="14935" checksum="0532FDE560E91D6F" modified="2022-01-19" version="1">MDVTRLLLATLLVFMCFFTTYSHLPPEEKPRDDRVLRSNSSMNLLDFSSVSIVALNKKFKRISRKEAEKKRSSKKEASVKKVAQPRPPPPAPCVATRFSCKPPAPACCDPCAYCHCRFFRSACSCRVLNPYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WVY2</accession>
    <name>A0A8B7WVY2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA damage regulated autophagy modulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DRAM2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DRAM/TMEM150 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012607081.1">
        <property type="nucleotide sequence ID" value="XM_012751627.3"/>
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        <property type="nucleotide sequence ID" value="XM_020283747.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_020283749.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139339.1">
        <property type="nucleotide sequence ID" value="XM_020283750.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139340.1">
        <property type="nucleotide sequence ID" value="XM_020283751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WVY2"/>
    <dbReference type="Ensembl" id="ENSMICT00000059147.1">
        <property type="protein sequence ID" value="ENSMICP00000042723.1"/>
        <property type="gene ID" value="ENSMICG00000011901.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864011"/>
    <dbReference type="KEGG" id="mmur:105864011"/>
    <dbReference type="CTD" id="128338"/>
    <dbReference type="GeneTree" id="ENSGT01030000234578"/>
    <dbReference type="OrthoDB" id="191706at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045494">
        <property type="term" value="P:photoreceptor cell maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF10">
        <property type="entry name" value="DNA DAMAGE-REGULATED AUTOPHAGY MODULATOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="266" mass="29955" checksum="29C76B1EEC976B17" modified="2022-01-19" version="1">MWWFQQGLSFLPSALVIWTSAAFIFSYITAVTLHHVDPALPYISDTGTVAPEKCLFGVMLNIAAVLCIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSIVANFQKTTLFLAHVSGAVLTFGMGSLYMFVQTILSYQMQPKIHGKQVFWIRLLLVIWCGVSAFSMLTCSSILYSGNFGTDLVQKLHWNPEDKGYVLHMITTAAEWSMSFTFFGFFLTYIRDFQKISLRVEANLHGLTLYDTAPCPINNERTRLLSRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UI23</accession>
    <name>A0A8C5UI23_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TRIM63</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03001830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UI23"/>
    <dbReference type="Ensembl" id="ENSMICT00000000187.3">
        <property type="protein sequence ID" value="ENSMICP00000000168.3"/>
        <property type="gene ID" value="ENSMICG00000000187.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156529"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070507">
        <property type="term" value="P:regulation of microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19831">
        <property type="entry name" value="Bbox2_MuRF1_C-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16759">
        <property type="entry name" value="RING-HC_MuRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000014">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase MID2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000022">
        <property type="entry name" value="Tripartite motif containing 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000140">
        <property type="entry name" value="Tripartite motif containing 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042667">
        <property type="entry name" value="TRIM63_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF17">
        <property type="entry name" value="TRIPARTITE MOTIF CONTAINING 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00502">
        <property type="entry name" value="BBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51262">
        <property type="entry name" value="COS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0514">Muscle protein</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="18">
        <location>
            <begin position="117"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="19">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="217"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000168.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="370" mass="41930" checksum="7C2B3867246A9415" modified="2022-01-19" version="1">MDYKSGLIQDGNPMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWTNRGGSMSTSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSMCKVFGAHKACEVAPLQNVFQGQKTELSNCISMLVAGNDRVQTIITQLEDSCRVTKENSHQVKETLSQKFDVLYAILDEKKSELLQRITQEQEEKLSFIEALIQQYQEQLEKSTKLVETAIQSLDEPGGATFLLSAKPLIKRSVGCSGKTEPGFENMDYFTLDLEYIADTLRAIDFGTDEEEEELIEEDQEEEESTEGKEEGKKFISLHPFLPSSLHSTTTGDTYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQL1</accession>
    <name>A0A8C5UQL1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 3-hydroxylase OGFOD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">uS12 prolyl 3-hydroxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">OGFOD1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024257">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611367.1">
        <property type="nucleotide sequence ID" value="XM_012755913.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQL1"/>
    <dbReference type="Ensembl" id="ENSMICT00000003869.3">
        <property type="protein sequence ID" value="ENSMICP00000003530.2"/>
        <property type="gene ID" value="ENSMICG00000003868.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866538"/>
    <dbReference type="KEGG" id="mmur:105866538"/>
    <dbReference type="CTD" id="55239"/>
    <dbReference type="GeneTree" id="ENSGT00390000002349"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
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        <property type="entry name" value="Prolyl 3-hydroxylase OGFOD1 isoform 1"/>
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        <property type="entry name" value="q2cbj1_9rhob like domain"/>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
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        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
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        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
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        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FE2OG_OXY"/>
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    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="19">
        <location>
            <begin position="134"/>
            <end position="239"/>
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        <location>
            <begin position="374"/>
            <end position="432"/>
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        <location>
            <begin position="384"/>
            <end position="403"/>
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        <location>
            <begin position="404"/>
            <end position="417"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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    <sequence length="541" mass="62504" checksum="BA8B81C5E3F86AAF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5USL0</accession>
    <name>A0A8C5USL0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 652</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF652</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a transcriptional repressor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with CBFA2T3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020094">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020095">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645157.1">
        <property type="nucleotide sequence ID" value="XM_012789703.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645158.1">
        <property type="nucleotide sequence ID" value="XM_012789704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5USL0"/>
    <dbReference type="Ensembl" id="ENSMICT00000006955.3">
        <property type="protein sequence ID" value="ENSMICP00000006336.2"/>
        <property type="gene ID" value="ENSMICG00000006959.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885089"/>
    <dbReference type="KEGG" id="mmur:105885089"/>
    <dbReference type="CTD" id="22834"/>
    <dbReference type="GeneTree" id="ENSGT00940000157416"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000900">
        <property type="entry name" value="Zinc finger and BTB domain containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger and BTB domain-containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000550">
        <property type="entry name" value="Zinc finger and BTB domain-containing 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000166">
        <property type="entry name" value="Zinc finger and BTB domain-containing 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001300">
        <property type="entry name" value="Zinc finger and BTB domain-containing protein 47"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000284">
        <property type="entry name" value="Zinc finger protein 652 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393:SF15">
        <property type="entry name" value="IP01243P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24393">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="247"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="274"/>
            <end position="301"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="301"/>
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    <feature type="domain" description="C2H2-type" evidence="16">
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            <begin position="331"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
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            <begin position="359"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="387"/>
            <end position="414"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="415"/>
            <end position="442"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="471"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="69"/>
            <end position="116"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="132"/>
            <end position="237"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="554"/>
            <end position="590"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="173"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="186"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="554"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059342"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065198"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006336.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="608" mass="69817" checksum="F13C646EE2BA09F6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVF3</accession>
    <name>A0A8C5UVF3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Arginine-glutamic acid dipeptide repeats protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">RERE</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03002449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000008500.3">
        <property type="protein sequence ID" value="ENSMICP00000007741.3"/>
        <property type="gene ID" value="ENSMICG00000008489.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153615"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04709">
        <property type="entry name" value="BAH_MTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11661">
        <property type="entry name" value="SANT_MTA3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000052">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.50:FF:000003">
        <property type="entry name" value="Arginine-glutamic acid dipeptide (RE) repeats a"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atrophin-1"/>
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    <dbReference type="InterPro" id="IPR002951">
        <property type="entry name" value="Atrophin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
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        <property type="entry name" value="ELM2_dom"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859:SF12">
        <property type="entry name" value="ARGININE-GLUTAMIC ACID DIPEPTIDE REPEATS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13859">
        <property type="entry name" value="ATROPHIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03154">
        <property type="entry name" value="Atrophin-1"/>
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    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01222">
        <property type="entry name" value="ATROPHIN"/>
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    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
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    </feature>
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    </feature>
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        </source>
    </evidence>
    <sequence length="1544" mass="170214" checksum="73E47E8BD9BD88AD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVX0</accession>
    <name>A0A8C5UVX0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative malate dehydrogenase 1B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MDH1B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVX0"/>
    <dbReference type="Ensembl" id="ENSMICT00000009487.3">
        <property type="protein sequence ID" value="ENSMICP00000008631.2"/>
        <property type="gene ID" value="ENSMICG00000009487.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063410"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016615">
        <property type="term" value="F:malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05295">
        <property type="entry name" value="MDH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000322">
        <property type="entry name" value="Putative malate dehydrogenase 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000006">
        <property type="entry name" value="putative malate dehydrogenase 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="7">
        <location>
            <begin position="290"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008631.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="512" mass="57574" checksum="F1A94786DF08251F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWZ7</accession>
    <name>A0A8C5UWZ7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 16">von Willebrand factor</fullName>
            <shortName evidence="16">vWF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">VWF</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14 16">Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Multimeric. Interacts with F8.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Secreted</location>
            <location evidence="1 16">Extracellular space</location>
            <location evidence="1 16">Extracellular matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Secreted</location>
        </subcellularLocation>
        <text evidence="16">Localized to storage granules.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000004801.3">
        <property type="protein sequence ID" value="ENSMICP00000004374.2"/>
        <property type="gene ID" value="ENSMICG00000004782.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155810"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033093">
        <property type="term" value="C:Weibel-Palade body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019865">
        <property type="term" value="F:immunoglobulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031589">
        <property type="term" value="P:cell-substrate adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902533">
        <property type="term" value="P:positive regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19941">
        <property type="entry name" value="TIL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="CDD" id="cd01450">
        <property type="entry name" value="vWFA_subfamily_ECM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000674">
        <property type="entry name" value="Mucin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000284">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000414">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000444">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000493">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000061">
        <property type="entry name" value="von Willebrand factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050780">
        <property type="entry name" value="Mucin_vWF_Thrombospondin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036084">
        <property type="entry name" value="Ser_inhib-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002919">
        <property type="entry name" value="TIL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058753">
        <property type="entry name" value="TIL_OTOGL_Mucin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037578">
        <property type="entry name" value="Von_Willebrand_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032361">
        <property type="entry name" value="VWA_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014853">
        <property type="entry name" value="VWF/SSPO/ZAN-like_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001007">
        <property type="entry name" value="VWF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001846">
        <property type="entry name" value="VWF_type-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF8">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OCEL" evidence="9">
        <location>
            <begin position="526"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="290"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006825.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="640" mass="72074" checksum="B0C0C064434AB957" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UYJ2</accession>
    <name>A0A8C5UYJ2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Keratin 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">KRT28</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UYJ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000009861.3">
        <property type="protein sequence ID" value="ENSMICP00000008980.2"/>
        <property type="gene ID" value="ENSMICG00000009865.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162192"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031069">
        <property type="term" value="P:hair follicle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002957">
        <property type="entry name" value="Keratin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239">
        <property type="entry name" value="INTERMEDIATE FILAMENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23239:SF215">
        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01248">
        <property type="entry name" value="TYPE1KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="6">
        <location>
            <begin position="86"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="259"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008980.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="464" mass="50440" checksum="75C184236029E1CD" modified="2022-01-19" version="1">MSLRFPGGSRHNCLRAGTGSVRPPSGGAGFAGSNACGSSVAGSGFSCTLGGGLGGVPSGSHASGALGNAAGMGFVGSEGGLLSGNEKVTMQNLNDRLASYLDNVRALEEANAELERKIKTWYEKYGPGSCRGLDHDYSRYHLTIEELKNKLISSTTANANVILQIDNARLAADDFRLKYENELALHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKALQCAAGGHVSVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSATLQQQISDDAGAATSARNELTEMKRTLQTLEIELQSLLATKQSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQKLEYEQLLDIKVHLEKEIETYCRLIDGDGNSCSKSKGFGSGSSGNSSKDLSKTTLVKTVVEEIDQRGKVISSRVHSIEEKTSKVTNGKTEQRVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZ55</accession>
    <name>A0A8C5UZ55_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">TSSK2</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="RefSeq" id="XP_012632088.1">
        <property type="nucleotide sequence ID" value="XM_012776634.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZ55"/>
    <dbReference type="Ensembl" id="ENSMICT00000008678.3">
        <property type="protein sequence ID" value="ENSMICP00000007906.2"/>
        <property type="gene ID" value="ENSMICG00000008686.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877757"/>
    <dbReference type="KEGG" id="mmur:105877757"/>
    <dbReference type="CTD" id="23617"/>
    <dbReference type="GeneTree" id="ENSGT00940000162226"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14165">
        <property type="entry name" value="STKc_TSSK1_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000443">
        <property type="entry name" value="Testis-specific serine/threonine-protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF102">
        <property type="entry name" value="TESTIS-SPECIFIC SERINE_THREONINE-PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="16" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="299"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007906.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="360" mass="41281" checksum="903ED542F334AA51" modified="2022-01-19" version="1">MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHRSIIKTYEIFETSDGRIYIVMELGVQGDLLEFIKCRGALHEDVARKMFRQLSSAVKYCHDMDVVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDGSGRIILSKTFCGSAAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIKKMLRIQKEHRVDFPRSKNLTGECKDLIYRMLQPDVNRRLHIDEILSHSWLQPPKPKAMSSASFKREGEGKYRAEYKLDTRPGSKPDHRPEHKLGAKTQHRLLVVPENEDRMEDRLAETSRAKDHHVSGAEVGKASNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V0C1</accession>
    <name>A0A8C5V0C1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Exonuclease 3'-5' domain-containing protein 2</fullName>
            <ecNumber evidence="5">3.1.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3'-5' exoribonuclease EXD2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Exonuclease 3'-5' domain-like-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">EXD2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Interacts with RBBP8, MRE11 and BRCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the EXD2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.1" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03003998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004000">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V0C1"/>
    <dbReference type="Ensembl" id="ENSMICT00000009598.3">
        <property type="protein sequence ID" value="ENSMICP00000008735.3"/>
        <property type="gene ID" value="ENSMICG00000009606.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014318"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045111">
        <property type="term" value="C:intermediate filament cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090734">
        <property type="term" value="C:site of DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000041">
        <property type="entry name" value="Exonuclease 3'-5' domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="3'-5' exonuclease" evidence="21">
        <location>
            <begin position="96"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="307"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00069878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00075515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008735.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="627" mass="70803" checksum="3DD1EDDDD6B6824D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1E8</accession>
    <name>A0A8C5V1E8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SH3 and cysteine-rich domain-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">STAC3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membrane. Slows down the inactivation rate of the calcium channel CACNA1C.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via SH3 domains) with the calcium channels CACNA1S and CACNA1C. Component of a calcium channel complex with CACNA1S and CACNB1. Component of a calcium channel complex with CACNA1C and CACNB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <location evidence="11">Sarcolemma</location>
            <location evidence="11">T-tubule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <location evidence="1">Sarcolemma</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009708">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632515.1">
        <property type="nucleotide sequence ID" value="XM_012777061.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1E8"/>
    <dbReference type="Ensembl" id="ENSMICT00000012375.3">
        <property type="protein sequence ID" value="ENSMICP00000011268.2"/>
        <property type="gene ID" value="ENSMICG00000012382.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877974"/>
    <dbReference type="KEGG" id="mmur:105877974"/>
    <dbReference type="CTD" id="246329"/>
    <dbReference type="GeneTree" id="ENSGT00950000183092"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003009">
        <property type="term" value="P:skeletal muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048741">
        <property type="term" value="P:skeletal muscle fiber development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20882">
        <property type="entry name" value="C1_Stac3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11986">
        <property type="entry name" value="SH3_Stac3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11834">
        <property type="entry name" value="SH3_Stac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000022">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000167">
        <property type="entry name" value="SH3 and cysteine-rich domain-containing protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039688">
        <property type="entry name" value="STAC1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035736">
        <property type="entry name" value="Stac3_SH3_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135:SF2">
        <property type="entry name" value="SH3 AND CYSTEINE-RICH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15135">
        <property type="entry name" value="STAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16664">
        <property type="entry name" value="STAC2_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="18">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="247"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="307"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="189"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="212"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00057005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011268.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="364" mass="41784" checksum="5A378055175745DC" modified="2022-01-19" version="1">MTEKEVLESPKPSLPAETRQSGLQRLTQLFRKGSTETKEMEIPPEPQANGEAVGAGGGPIYYIYEEEEEEEEEEEEPPPEPPKLVNDKPHKFKDHFFKKPKFCDVCARMIVLNNKFGLRCKNCKTNIHEHCQSYVEMQRCFGKIPPGFHRAYSSPLYSNQQYACVKDLSTANRNDPVFETLRTGVIMANKERKKGQADKKNPLAAMMEEEPESARPEEGKPRDGLPERDKKTEKKTPDDKHKQPGFQQSHYFVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQITLKKDQIVVQKGDETGGYVKVYTGRKMGLFPADFLEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2F7</accession>
    <name>A0A8C5V2F7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ATP binding cassette subfamily A member 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ABCA12</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010794">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010795">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000014562.3">
        <property type="protein sequence ID" value="ENSMICP00000013275.3"/>
        <property type="gene ID" value="ENSMICG00000014502.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157295"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097234">
        <property type="term" value="C:epidermal lamellar body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034191">
        <property type="term" value="F:apolipoprotein A-I receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035627">
        <property type="term" value="P:ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003336">
        <property type="term" value="P:corneocyte desquamation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048286">
        <property type="term" value="P:lung alveolus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033700">
        <property type="term" value="P:phospholipid efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010875">
        <property type="term" value="P:positive regulation of cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032379">
        <property type="term" value="P:positive regulation of intracellular lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000010">
        <property type="term" value="P:positive regulation of protein localization to cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045055">
        <property type="term" value="P:regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061178">
        <property type="term" value="P:regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045616">
        <property type="term" value="P:regulation of keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043129">
        <property type="term" value="P:surfactant homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000689">
        <property type="entry name" value="ATP binding cassette subfamily A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000298">
        <property type="entry name" value="ATP-binding cassette sub-family A member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056264">
        <property type="entry name" value="R2_ABCA1-4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF29">
        <property type="entry name" value="GLUCOSYLCERAMIDE TRANSPORTER ABCA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23321">
        <property type="entry name" value="R1_ABCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1064"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1108"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1173"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1247"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1743"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1984"/>
            <end position="2006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2026"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2058"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2089"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2176"/>
            <end position="2197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="1343"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="2244"/>
            <end position="2479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013275.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2585" mass="292286" checksum="1F4D4F126A868C8A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V443</accession>
    <name>A0A8C5V443_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma-tubulin complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TUBGCP5</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-tubulin ring complex (gTuRC) consisting of TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 and gamma-tubulin TUBG1 or TUBG2. TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 assemble in a 5:5:2:1:1 stoichiometry; each is associated with a gamma-tubulin, thereby arranging 14 gamma-tubulins in a helical manner. Gamma-tubulin at the first position is blocked by TUBGCP3 at the last position, allowing 13 protafilaments to grow into a microtubule. The gTuRC (via TUBGCP3 and TUBGCP6) interacts with ACTB and MZT1; the interactions form a luminal bridge that stabilizes the initial structure during complex assembly. The gTuRC (via TUBGCP2) interacts with MZT2A/MZT2B and CDK5RAP2 (via CM1 motif); the interactions play a role in gTuRC activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013952">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615715.1">
        <property type="nucleotide sequence ID" value="XM_012760261.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V443"/>
    <dbReference type="Ensembl" id="ENSMICT00000012976.3">
        <property type="protein sequence ID" value="ENSMICP00000011825.2"/>
        <property type="gene ID" value="ENSMICG00000012969.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868897"/>
    <dbReference type="CTD" id="114791"/>
    <dbReference type="GeneTree" id="ENSGT00940000155962"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1900:FF:000005">
        <property type="entry name" value="Gamma-tubulin complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="11">
        <location>
            <begin position="272"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="10">
        <location>
            <begin position="717"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011825.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1025" mass="118424" checksum="34BF26B2DEF02DD4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V4R8</accession>
    <name>A0A8C5V4R8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coagulation factor IX</fullName>
            <ecNumber evidence="4">3.4.21.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Christmas factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">F9</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.</text>
            <dbReference type="EC" id="3.4.21.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.22" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03035417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637954.1">
        <property type="nucleotide sequence ID" value="XM_012782500.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V4R8"/>
    <dbReference type="Ensembl" id="ENSMICT00000016430.3">
        <property type="protein sequence ID" value="ENSMICP00000014975.3"/>
        <property type="gene ID" value="ENSMICG00000016427.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881058"/>
    <dbReference type="KEGG" id="mmur:105881058"/>
    <dbReference type="CTD" id="2158"/>
    <dbReference type="GeneTree" id="ENSGT00940000159516"/>
    <dbReference type="OrthoDB" id="8909918at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031638">
        <property type="term" value="P:zymogen activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000259">
        <property type="entry name" value="Coagulation factor VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000013">
        <property type="entry name" value="Coagulation factor X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000162">
        <property type="entry name" value="Coagulation factor X (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.740.10:FF:000001">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.740.10">
        <property type="entry name" value="Coagulation Factor IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017857">
        <property type="entry name" value="Coagulation_fac-like_Gla_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035972">
        <property type="entry name" value="GLA-like_dom_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000294">
        <property type="entry name" value="GLA_domain"/>
    </dbReference>
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        <property type="entry name" value="Pept_S1A_FX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050442">
        <property type="entry name" value="Peptidase_S1_coag_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278">
        <property type="entry name" value="COAGULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24278:SF31">
        <property type="entry name" value="COAGULATION FACTOR IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00594">
        <property type="entry name" value="Gla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001143">
        <property type="entry name" value="Factor_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00010">
        <property type="entry name" value="EGFBLOOD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00001">
        <property type="entry name" value="GLABLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00069">
        <property type="entry name" value="GLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57630">
        <property type="entry name" value="GLA-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_1"/>
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    </dbReference>
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        <property type="entry name" value="EGF_2"/>
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    </dbReference>
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        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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        <property type="entry name" value="GLA_1"/>
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    </dbReference>
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        <property type="entry name" value="GLA_2"/>
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    </dbReference>
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        <property type="entry name" value="TRYPSIN_DOM"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="12" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="21 26" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 26" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6" id="KW-0301">Gamma-carboxyglutamic acid</keyword>
    <keyword evidence="22" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="15 27" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="23" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 27" id="KW-0645">Protease</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="16 27" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0765">Sulfation</keyword>
    <keyword evidence="20" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Gla" evidence="30">
        <location>
            <begin position="47"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="28">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="29">
        <location>
            <begin position="227"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="25">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="25">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="25">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="26">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022641"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022670"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022685"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
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            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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        <source>
            <dbReference type="PROSITE" id="PS50240"/>
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            <dbReference type="PROSITE" id="PS50998"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="461" mass="51772" checksum="2C83710E629D1973" modified="2022-01-19" version="1">MQCLNMIMAESPGLVTICLLGYLLIAECAVFLDRENANKILSRPKRYNSGKLEEFVRGNLERECIEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCRLGFEGKNCELDASCSIKNGRCKQFCKKSADNKVVCSCTEGYRLAENKKSCEPAVPFPCGRVSVSHTSKFTRAETIFSNMDYENSTEVETILDNVTESTHSPQDITRVVGGENAKPGQFPWQVILNGKIDAFCGGSIVNEKWVVTAAHCIVPPVNITVVAGEHDIEKTEPTEQKRKVIRVILHHSYNATVNKYSHDIALLELDKPLTLNSYVTPICIADREYTNIFLKFGSGYVSGWGRVFHRGRSASILQYLRVPFVDRATCLRSTKVTIHNNMFCAGYHEGGRDSCQGDSGGPHITEVEGTNFLTGIISWGEECAMKGKYGIYTKVSRYTNWIKEKTKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7I9</accession>
    <name>A0A8C5V7I9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Short chain dehydrogenase/reductase family 42E, member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SDR42E1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023453">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7I9"/>
    <dbReference type="Ensembl" id="ENSMICT00000015164.3">
        <property type="protein sequence ID" value="ENSMICP00000013832.3"/>
        <property type="gene ID" value="ENSMICG00000015171.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158070"/>
    <dbReference type="OMA" id="IGAYKRS"/>
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        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000138">
        <property type="entry name" value="Short-chain dehydrogenase/reductase family 42E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013832.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="392" mass="43760" checksum="9C04692DCD4B8481" modified="2022-01-19" version="1">MDAEKSPAETVLITGGGGYFGFLGCALNQQGVHVILFDINSPAETIPEGIKFARGDIRHLSDVENAFQDANVTCVFHIASYGMSGREQLNGNLIEEVNVGGTDNVLQACRRRGVPRLVYTSTFNVIFGGQVIRNGDESLPYLPLHLHPDHYSRTKSIAERKVLEANGTLLETGDGVLRTCALRPAGIYGPGERRHLPRIVSYIERGLFKFVYGDPGSLVEFVHVDNLVQAHILASEALKADKGYIASGQPYFISDGRPVNNFEFFRPLVEGLGYTFPSTRLPLYLIYCFAFLTEMAHFLLGRLYNFQPFLTRTEVYKTGVTHYFSLEKAKKELGYEAQPFDLQEVVEWFKAHGHGRSPGSHGSEYHVWRGLLVFFLVIAVLTWLLPSVILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9J2</accession>
    <name>A0A8C5V9J2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING finger protein 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">RNF24</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">May play a role in TRPCs intracellular trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021672">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610434.1">
        <property type="nucleotide sequence ID" value="XM_012754980.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9J2"/>
    <dbReference type="Ensembl" id="ENSMICT00000049555.2">
        <property type="protein sequence ID" value="ENSMICP00000016342.1"/>
        <property type="gene ID" value="ENSMICG00000038625.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105865938"/>
    <dbReference type="CTD" id="11237"/>
    <dbReference type="GeneTree" id="ENSGT00940000159443"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16675">
        <property type="entry name" value="RING-H2_RNF24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000260">
        <property type="entry name" value="RING finger protein 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048025">
        <property type="entry name" value="RNF24_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF190">
        <property type="entry name" value="RING FINGER PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="160" mass="18347" checksum="6C3DA2D133CE716B" modified="2022-01-19" version="1">MSAAAAGDHDLPMSSDFPHYNFRMPNIGFQNLPLNIYIVVFGTAIFVFILSLLFCCYLIRLRHQAHKEFYAYKQVILKEKVKELNLHELCAVCLEDFKPRDELGICPCKHAFHRKCLIKWLEVRKVCPLCNMPVLQLAQLHSKQDRGPPQGPLPGAENIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9Y8</accession>
    <name>A0A8C5V9Y8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Outer dense fiber protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cenexin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Outer dense fiber of sperm tails protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ODF2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to the centrosomes. Required for the formation and/or maintenance of normal CETN1 assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ODF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014913">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9Y8"/>
    <dbReference type="Ensembl" id="ENSMICT00000017639.3">
        <property type="protein sequence ID" value="ENSMICP00000016062.3"/>
        <property type="gene ID" value="ENSMICG00000017639.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063497"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026099">
        <property type="entry name" value="Odf2-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162">
        <property type="entry name" value="OUTER DENSE FIBER OF SPERM TAILS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23162:SF8">
        <property type="entry name" value="OUTER DENSE FIBER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0744">Spermatogenesis</keyword>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="148"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="304"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="522"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016062.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="829" mass="95504" checksum="E662057DDC574D79" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VC45</accession>
    <name>A0A8C5VC45_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Plakophilin-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PKP2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with DSC2. Interacts with JUP. Interacts with KRT5/CK5, KRT8/CK8, KRT14/CK14, KRT18/CK18 and VIM. Interacts (via N-terminus) with MARK3/C-TAK1. Interacts with DSP. Interacts with DSG1, DSG2 and DSG3. Interacts (via N-terminus) with CTNNB1. Interacts with CDH1. Interacts with the RNA polymerase III (Pol III) complex proteins POLR3A/RPC155, POLR3F/RPC39 and POLR3C/RPC82. Interacts with CTNNA3. Interacts (via N-terminus) with SCN5A/Nav1.5. Interacts with ANK3/ANKG and GJA1/CX43.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009876">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009879">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009882">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644690.2">
        <property type="nucleotide sequence ID" value="XM_012789236.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VC45"/>
    <dbReference type="Ensembl" id="ENSMICT00000001166.3">
        <property type="protein sequence ID" value="ENSMICP00000001061.3"/>
        <property type="gene ID" value="ENSMICG00000001164.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000052889.2">
        <property type="protein sequence ID" value="ENSMICP00000019608.2"/>
        <property type="gene ID" value="ENSMICG00000001164.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105884877"/>
    <dbReference type="CTD" id="5318"/>
    <dbReference type="GeneTree" id="ENSGT00940000158677"/>
    <dbReference type="OrthoDB" id="3245100at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014704">
        <property type="term" value="C:intercalated disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045294">
        <property type="term" value="F:alpha-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019215">
        <property type="term" value="F:intermediate filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005080">
        <property type="term" value="F:protein kinase C binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086073">
        <property type="term" value="P:bundle of His cell-Purkinje myocyte adhesion involved in cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002159">
        <property type="term" value="P:desmosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048496">
        <property type="term" value="P:maintenance of animal organ identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900024">
        <property type="term" value="P:regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098911">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086005">
        <property type="term" value="P:ventricular cardiac muscle cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055010">
        <property type="term" value="P:ventricular cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000159">
        <property type="entry name" value="Plakophilin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF25">
        <property type="entry name" value="PLAKOPHILIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ARM" evidence="15">
        <location>
            <begin position="396"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="15">
        <location>
            <begin position="438"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019608.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="838" mass="92695" checksum="2F66096493CF4A6E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCH1</accession>
    <name>A0A8C5VCH1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="primary">GRIN2D</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potasium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators.</text>
    </comment>
    <comment type="function">
        <text evidence="29">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="25">Heterotetramer. Forms heterotetrameric channels composed of two GluN1/zeta subunits (GRIN1), and two identical GluN2/epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) or GluN3 subunits (GRIN3A or GRIN3B) (in vitro). In vivo, the subunit composition may depend on the expression levels of the different subunits. Interacts with PDZ domains of PATJ and DLG4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19 29">Postsynaptic cell membrane</location>
            <topology evidence="19 29">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609814.1">
        <property type="nucleotide sequence ID" value="XM_012754360.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000034831.2">
        <property type="protein sequence ID" value="ENSMICP00000019842.1"/>
        <property type="gene ID" value="ENSMICG00000008869.3"/>
    </dbReference>
    <dbReference type="CTD" id="2906"/>
    <dbReference type="GeneTree" id="ENSGT00940000159109"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017146">
        <property type="term" value="C:NMDA selective glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022849">
        <property type="term" value="F:glutamate-gated calcium ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004972">
        <property type="term" value="F:NMDA glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097553">
        <property type="term" value="P:calcium ion transmembrane import into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051930">
        <property type="term" value="P:regulation of sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001964">
        <property type="term" value="P:startle response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06378">
        <property type="entry name" value="PBP1_iGluR_NMDA_NR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13718">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000626">
        <property type="entry name" value="Glutamate ionotropic receptor NMDA type subunit 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000397">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000007">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 29" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 28" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="18 29" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 29" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 29" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 29" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16 29" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="14 29" id="KW-0675">Receptor</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 29" id="KW-0732">Signal</keyword>
    <keyword evidence="10 29" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 29" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 29" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 29" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039455" description="Glutamate receptor" evidence="29">
        <location>
            <begin position="26"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="628"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="29">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="31">
        <location>
            <begin position="465"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="32">
        <location>
            <begin position="473"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="900"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="981"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1212"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="30">
        <location>
            <begin position="902"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="981"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="30">
        <location>
            <begin position="992"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="30">
        <location>
            <begin position="1074"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="30">
        <location>
            <begin position="1090"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="30">
        <location>
            <begin position="1219"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="541"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="717"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="718"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="27">
        <location>
            <position position="690"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="27">
        <location>
            <position position="723"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="28">
        <location>
            <begin position="773"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00056249"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00061683"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00063280"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1335" mass="143713" checksum="A258D8AC960023DC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCS1</accession>
    <name>A0A8C5VCS1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gamma-aminobutyric acid receptor subunit alpha-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">GABA(A) receptor subunit alpha-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">GABRA2</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="25">Postsynaptic cell membrane</location>
            <topology evidence="25">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029311">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029312">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029313">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VCS1"/>
    <dbReference type="Ensembl" id="ENSMICT00000031391.2">
        <property type="protein sequence ID" value="ENSMICP00000019992.2"/>
        <property type="gene ID" value="ENSMICG00000013839.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157266"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060077">
        <property type="term" value="C:inhibitory synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008503">
        <property type="term" value="F:benzodiazepine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022851">
        <property type="term" value="F:GABA-gated chloride ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099507">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19035">
        <property type="entry name" value="LGIC_ECD_GABAAR_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005432">
        <property type="entry name" value="GABBAa2_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047023">
        <property type="entry name" value="Gabra-2_ECD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01615">
        <property type="entry name" value="GABAARALPHA2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0868">Chloride</keyword>
    <keyword evidence="15" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21 26" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 26" id="KW-0406">Ion transport</keyword>
    <keyword evidence="20" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="12 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 26" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0770">Synapse</keyword>
    <keyword evidence="7 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 26" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034717318" description="Gamma-aminobutyric acid receptor subunit alpha-2" evidence="26">
        <location>
            <begin position="29"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="27">
        <location>
            <begin position="43"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="28">
        <location>
            <begin position="257"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="28">
        <location>
            <begin position="403"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00033009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019992.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="475" mass="54301" checksum="15119038D718A6E8" modified="2022-01-19" version="1">MKMKSDTHNMQLLLLVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQRWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVEVAPDGSRLNQYDLLGQSVGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGEWAHTLFARNSSKVAYATAMDWFIAVCYLSKEEAWEEESEGIILRYNSVKAILQGAKLIWSKYIAFSWPSLIQEKTLGHLEKWMDCLNLQTIFCKASVTIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VG84</accession>
    <name>A0A8C5VG84_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014884">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VG84"/>
    <dbReference type="Ensembl" id="ENSMICT00000041158.2">
        <property type="protein sequence ID" value="ENSMICP00000022049.1"/>
        <property type="gene ID" value="ENSMICG00000037534.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234866"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="101" mass="10613" checksum="91579E9F44BB4821" modified="2022-01-19" version="1">MEEQAQSLTDRTTAAFQQGAIPPTPTSAPPPAGERIPAPPSLLGPPRPGMKPEPHMGVGPAPAKRPPMGGQMPRMPEPPLMRPPARPMTVPTRPGMTGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM96</accession>
    <name>A0A8C5VM96_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PIP5K1A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03002973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622997.1">
        <property type="nucleotide sequence ID" value="XM_012767543.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM96"/>
    <dbReference type="Ensembl" id="ENSMICT00000048831.2">
        <property type="protein sequence ID" value="ENSMICP00000023420.2"/>
        <property type="gene ID" value="ENSMICG00000033339.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873022"/>
    <dbReference type="CTD" id="8394"/>
    <dbReference type="GeneTree" id="ENSGT00940000154703"/>
    <dbReference type="OrthoDB" id="70770at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010761">
        <property type="term" value="P:fibroblast migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048041">
        <property type="term" value="P:focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17306">
        <property type="entry name" value="PIPKc_PIP5K1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000001">
        <property type="entry name" value="phosphatidylinositol 4-phosphate 5-kinase type-1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF54">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE TYPE-1 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="67"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023420.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="548" mass="60928" checksum="863D3FE034D1F8E6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMW1</accession>
    <name>A0A8C5VMW1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03036406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMW1"/>
    <dbReference type="Ensembl" id="ENSMICT00000053959.2">
        <property type="protein sequence ID" value="ENSMICP00000024312.1"/>
        <property type="gene ID" value="ENSMICG00000034748.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183180"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15578">
        <property type="entry name" value="PHD1_MTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.980.20:FF:000025">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000126">
        <property type="entry name" value="metal-response element-binding transcription factor 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025894">
        <property type="entry name" value="Mtf2_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042014">
        <property type="entry name" value="MTF2_PHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF12">
        <property type="entry name" value="METAL-RESPONSE ELEMENT-BINDING TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14061">
        <property type="entry name" value="Mtf2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="10">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="497" mass="56740" checksum="7575F3683EA42868" modified="2022-01-19" version="1">MKRLAPLKLYTGKMNKKPACKYEEGQDVLARGSDGFCLIIFEDSSKSWVLWKDIQAGATGSGEVVCTICQEEYPDAPNKMVIYDKCGQGYHQLCHTSRIDSNVIDSDEKWLCRQCFFATTKRGGVLKKGLNAKVLQIMKHTLPYSVADLEWDAGHKTRVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLLGDRFYTFTCSWVDIAHLCLYSLSVIHKKKYFDSELELMTYINENWDRLRPGELADTPKSERYEHVLEALNDYKTIFMSGKEMKKKHLFGLRIHVSPVPPNVAFKAEKEPEGTSHEFKIKVNRKTSKPISDSRDVSNGIDKKGKKNSIGRPPGPYIRKMIQKTAEPPLDKELVSENPTLDLPYADFKGASSAKETTSSSTSGYYGLFYSRKRTHTGRSWPAAIPHLRRRRGCLPRRAFQTQNSEIVKDDESKEDYQFLELNTEILNNLADQELQLNHPKNSITSYFGGAGRIACGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VPD7</accession>
    <name>A0A8C5VPD7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Interferon regulatory factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IRF5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644633.2">
        <property type="nucleotide sequence ID" value="XM_012789179.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VPD7"/>
    <dbReference type="Ensembl" id="ENSMICT00000035632.2">
        <property type="protein sequence ID" value="ENSMICP00000024572.2"/>
        <property type="gene ID" value="ENSMICG00000000138.3"/>
    </dbReference>
    <dbReference type="CTD" id="3663"/>
    <dbReference type="GeneTree" id="ENSGT00940000159926"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120283">
        <property type="term" value="F:protein serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071225">
        <property type="term" value="P:cellular response to muramyl dipeptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071224">
        <property type="term" value="P:cellular response to peptidoglycan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070431">
        <property type="term" value="P:nucleotide-binding oligomerization domain containing 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002720">
        <property type="term" value="P:positive regulation of cytokine production involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032727">
        <property type="term" value="P:positive regulation of interferon-alpha production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032735">
        <property type="term" value="P:positive regulation of interleukin-12 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00103">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000003">
        <property type="entry name" value="Interferon regulatory factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000093">
        <property type="entry name" value="Putative interferon regulatory factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019817">
        <property type="entry name" value="Interferon_reg_fac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001346">
        <property type="entry name" value="Interferon_reg_fact_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019471">
        <property type="entry name" value="Interferon_reg_factor-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11949:SF10">
        <property type="entry name" value="INTERFERON REGULATORY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00605">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10401">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00267">
        <property type="entry name" value="INTFRNREGFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00348">
        <property type="entry name" value="IRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01243">
        <property type="entry name" value="IRF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="IRF tryptophan pentad repeat" evidence="9">
        <location>
            <begin position="14"/>
            <end position="122"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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            <dbReference type="PROSITE" id="PS51507"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024572.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VVD1</accession>
    <name>A0A8C5VVD1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">TPX2 microtubule nucleation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TPX2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle pole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPX2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021643">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021644">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021645">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VVD1"/>
    <dbReference type="Ensembl" id="ENSMICT00000030473.2">
        <property type="protein sequence ID" value="ENSMICP00000031041.2"/>
        <property type="gene ID" value="ENSMICG00000015833.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009842"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
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    <dbReference type="GO" id="GO:0043203">
        <property type="term" value="C:axon hillock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061676">
        <property type="term" value="F:importin-alpha family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015128">
        <property type="entry name" value="Aurora-A-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF44">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09041">
        <property type="entry name" value="Aurora-A_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aurora-A binding" evidence="15">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="TPX2 central" evidence="16">
        <location>
            <begin position="364"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="TPX2 C-terminal" evidence="14">
        <location>
            <begin position="572"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="107"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031041.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="659" mass="75607" checksum="FA0FC0235DF0AC0C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWN0</accession>
    <name>A0A8C5VWN0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 11 open reading frame 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C11orf42</name>
        <name evidence="2" type="synonym">C5H11orf42</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03006436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWN0"/>
    <dbReference type="Ensembl" id="ENSMICT00000031279.2">
        <property type="protein sequence ID" value="ENSMICP00000026818.1"/>
        <property type="gene ID" value="ENSMICG00000033046.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105883460"/>
    <dbReference type="GeneTree" id="ENSGT00390000016268"/>
    <dbReference type="OrthoDB" id="9042900at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031366">
        <property type="entry name" value="DUF4663"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36872">
        <property type="entry name" value="GENE 5901-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36872:SF1">
        <property type="entry name" value="GENE 5901-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15668">
        <property type="entry name" value="DUF4663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="36554" checksum="B44364101197E9BF" modified="2022-01-19" version="1">MLVGTPHLLTLDEADATWTLIKDKVIEERFGSKVVAVPFLSDAACYDLLGVLVKQSRPAHTRLALPGRQGRKALKPVGPLPNLLEQTGSEGTFAHCTQEYSPNGRAEITYEEMRLLDGQPCRIHLRMGGLRKKVAFLLLPPGQVSLQQTLPWLRSTHSIYIIYQVFSCSWLQLGLLPTAREPQLLRLQRSLPIAFTCLKFSLQPKGVLGPQKPLTKDPLLHGANWVRPNLSIITPLAPTSAPANTSEAADMPPPVPAPPTAPPQEGPEGRPTRFSYKGRNPFRRGPQMLSENWLFSPRSPPPGAQGGDPGDPDRHSMSLPLLQGLSSEFDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0M6</accession>
    <name>A0A8C5W0M6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W0M6"/>
    <dbReference type="Ensembl" id="ENSMICT00000040736.2">
        <property type="protein sequence ID" value="ENSMICP00000034258.2"/>
        <property type="gene ID" value="ENSMICG00000026653.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163047"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000185">
        <property type="entry name" value="zinc finger protein 319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001472">
        <property type="entry name" value="Zinc finger protein 324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001471">
        <property type="entry name" value="Zinc finger protein 324A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000902">
        <property type="entry name" value="Zinc finger protein 445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000200">
        <property type="entry name" value="zinc finger protein 510 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000410">
        <property type="entry name" value="Zinc finger protein 777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="408"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034258.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="471" mass="51370" checksum="631771C4BD77BCDE" modified="2022-01-19" version="1">SWCLAEDRDVSGEAASPGALPGSPPGMATRVFPVVGACHSAKSLEGQWGASPSQERKPTGVSMIYWERLLLGSGTGQASVSLRLTSPLRPLEGGGSMEKARTGRPLPGMQPTVPKRRKPYVGNAPGRAFRSVPDVASVSTRQEHGMSVAWREPQRLPSDQEPRTWEELGEAPHAGPGLPGEKPFECRACSKVFVKSSDLLKHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSGETPYACTACGKAFRHSSSLVRHQRIHTAEKSFRCGECGKAFSHGSNLSQHRKIHAGGRPYACGQCGRRFCRNSHLIQHERTHTGEKPYACALCGAAFSQGSSLFKHQRVHTGEKPFSCAQCGRAFSHSSNLTQHQLLHTGERPFRCADCGKAFAKGAVLLSHQRIHTGEKPFVCAQCGRAFRERPALFHHQRIHTGEKSGRPSPACAPRPGFHRGHHRMVRRGGTQSSIPKAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1N3</accession>
    <name>A0A8C5W1N3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 139</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03015146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5W1N3"/>
    <dbReference type="Ensembl" id="ENSMICT00000045429.2">
        <property type="protein sequence ID" value="ENSMICP00000035124.2"/>
        <property type="gene ID" value="ENSMICG00000030179.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002723"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038805">
        <property type="entry name" value="TMEM139"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36294">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36294:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 139"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="39"/>
            <end position="63"/>
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            <end position="152"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035124.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="206" mass="22810" checksum="2612BDF068D7D3B3" modified="2022-01-19" version="1">MVPSHLWGRLEKPFIFLCCASLLLGLALLGVRPDFAPVAYFFLALGGFFLFACLLACFVEWGLRLRLQSMQSESPRAPGNARDNDAFEVPAYEESVVVLESRYHHQEVDQPPPYSSVVIPPGLEEGQEGHTTRLERRVGSEGSMAQERSPGRIQVSHQLQGPQAVSTAPDLRSLAALHKLEPLTPPPAYDICFGHPDDNSVFREDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1T8</accession>
    <name>A0A8C5W1T8_MICMU</name>
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            <fullName evidence="2">Thromboxane A2 receptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Prostanoid TP receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TBXA2R</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03028023">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1T8"/>
    <dbReference type="Ensembl" id="ENSMICT00000047256.2">
        <property type="protein sequence ID" value="ENSMICP00000033396.2"/>
        <property type="gene ID" value="ENSMICG00000031426.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234559"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
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    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:negative regulation of cell migration involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045777">
        <property type="term" value="P:positive regulation of blood pressure"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045987">
        <property type="term" value="P:positive regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045907">
        <property type="term" value="P:positive regulation of vasoconstriction"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Thromboxane A2 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008365">
        <property type="entry name" value="Prostanoid_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001105">
        <property type="entry name" value="Thbox_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11866:SF5">
        <property type="entry name" value="THROMBOXANE A2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01788">
        <property type="entry name" value="PROSTANOIDR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00429">
        <property type="entry name" value="THROMBOXANER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
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    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="107"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
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            <begin position="149"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="41"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033396.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="315" mass="34438" checksum="9C234F475436BC83" modified="2022-01-19" version="1">MWSNDSSLGPCFRPTNTSVEERRLIASPWFAASFCVAGLASNLLALSVLAGARQAGPHPRSSFLTFLCGLVLTDFLGLLVTGSIVVAQHAALFDWRAADPGCRLCRFMGVAMVFFGLCPLLLGAAMASERCLGIARPFSRPAAASPRRAWAAVGLAWAAALALALLPLLGLGRYSVQFPGSWCFLTLGARVATLCRVYHGRQAARQRPRDGEVEMMAQLLGIMVVASVCWMPLLVFIAQTLLRSPPAMSPTGQLPRATEKQLLIYLRVATWNQILDPWVYILFRRAVLRRLQPRRSLRPGSLSLRPQRPRGSVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1W6</accession>
    <name>A0A8C5W1W6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105866785</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012492">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1W6"/>
    <dbReference type="Ensembl" id="ENSMICT00000033367.2">
        <property type="protein sequence ID" value="ENSMICP00000030737.2"/>
        <property type="gene ID" value="ENSMICG00000027477.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230401"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000204">
        <property type="entry name" value="Heat shock protein HSP 90-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="201"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="631"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="219"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030737.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="76286" checksum="E48C0850602A2FA5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W236</accession>
    <name>A0A8C5W236_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Keratin, type I cytoskeletal 25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytokeratin-25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Keratin-25</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Type I inner root sheath-specific keratin-K25irs1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">KRT25</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Plays a role in the cytoskeleton organization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a type I and a type II keratin. Heterodimer with type II keratin KRT5 leading to the formation of keratin intermediate filament (KIF) network. Interacts with KRT6A to form filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621273.1">
        <property type="nucleotide sequence ID" value="XM_012765819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W236"/>
    <dbReference type="Ensembl" id="ENSMICT00000052741.2">
        <property type="protein sequence ID" value="ENSMICP00000031746.1"/>
        <property type="gene ID" value="ENSMICG00000027114.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105872070"/>
    <dbReference type="KEGG" id="mmur:105872070"/>
    <dbReference type="CTD" id="147183"/>
    <dbReference type="GeneTree" id="ENSGT00940000161994"/>
    <dbReference type="OrthoDB" id="2441647at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031069">
        <property type="term" value="P:hair follicle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000002">
        <property type="entry name" value="Type I keratin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000002">
        <property type="entry name" value="Type I keratin KA11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KERATIN, TYPE I CYTOSKELETAL 25"/>
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    </dbReference>
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        <property type="entry name" value="TYPE1KERATIN"/>
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    <keyword evidence="5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="4" id="KW-0416">Keratin</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
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            <begin position="79"/>
            <end position="394"/>
        </location>
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            <begin position="1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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</entry>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
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                <person name="Doddapaneni H."/>
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                <person name="Gnanaolivu R."/>
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                <person name="Javaid M."/>
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                <person name="Li M."/>
                <person name="Mathew T."/>
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                <person name="Nguyen L."/>
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                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ZN839"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
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            <begin position="13"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006038.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="829" mass="88797" checksum="649C38EC60D1B545" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XES2</accession>
    <name>A0A8C5XES2_MICMU</name>
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        <submittedName>
            <fullName evidence="4">Immunoglobulin superfamily member 6</fullName>
        </submittedName>
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        <name evidence="4" type="primary">IGSF6</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020994">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000016042.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014131"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039089">
        <property type="entry name" value="IGSF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15297">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15297:SF2">
        <property type="entry name" value="IMMUNOGLOBULIN SUPERFAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
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            <end position="33"/>
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        <location>
            <begin position="154"/>
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            <begin position="216"/>
            <end position="241"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="241" mass="27355" checksum="1F185D30E64042F6" modified="2022-01-19" version="1">MRTVNRGHLDLRLQVSLILFYVGAVGACTVSVIQPHYLEVDYTQEAVTIECNFSATKCPSEHPTSLWFRYGTHQPENLCQDGCRSEADKFTVRENLVQNQVSLTVNRVTSNDSAIYICGIAFPSAKEPRAKQTGGGTTLVVREIELLSKELRSLLTAVLSLLSIYITGLCVVFIVLSKSKSNTLRNKETKEDSQKKKSARRIFQEIAQELYHKRYVETSQQPEKEDNTYENRRALSNYERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XFC9</accession>
    <name>A0A8C5XFC9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein TEX261</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TEX261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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        <lineage>
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            <taxon>Eutheria</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the SVP26 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000044484.2">
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        <property type="gene ID" value="ENSMICG00000031861.2"/>
    </dbReference>
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    <dbReference type="KEGG" id="mmur:105863255"/>
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    <dbReference type="OrthoDB" id="28257at2759"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:COPII receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007277">
        <property type="entry name" value="Svp26/Tex261"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN TEX261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13144">
        <property type="entry name" value="TEX261 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04148">
        <property type="entry name" value="Erv26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008096"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016758.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="196" mass="22538" checksum="790D3E3E5232FF8C" modified="2022-01-19" version="1">MWFMYVLSWLSLFIQVAFITLAVAAGLYYLAELIEEYTVATSRIIKYMIWFSTAVLIGLYVFERFPTSMIGVGLFTNLVYFGLLQTFPFIMLTSPNFILSCGLVVVNHYLAFQFFAEEYYPFSEVLAYFTFCLWIIPFAFFVSLSAGENILPSTMQPGDDVVSNYFTKGKRGKRLGILVVFSFIKEAILPSRQKIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XFX9</accession>
    <name>A0A8C5XFX9_MICMU</name>
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        <submittedName>
            <fullName evidence="7">EF-hand domain family member D1</fullName>
        </submittedName>
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        <name evidence="7" type="primary">EFHD1</name>
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        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
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                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
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                <person name="Gnanaolivu R."/>
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                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
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                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
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                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
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                <person name="Rajbhandari K."/>
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                <person name="Santibanez J."/>
                <person name="Sexton D."/>
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                <person name="Wu Y."/>
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                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
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                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XKS1</accession>
    <name>A0A8C5XKS1_MICMU</name>
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            <fullName evidence="12">1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase</fullName>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
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                <person name="Rajbhandari K."/>
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                <person name="Sullivan B."/>
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                <person name="Machol I."/>
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                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
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                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58433"/>
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            <dbReference type="Rhea" id="RHEA:43485"/>
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    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
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            <dbReference type="Rhea" id="RHEA:33180"/>
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    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with RAC1. Forms a complex composed of at least WDR26, a G-beta:gamma unit, and PLCB2.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000032808.2"/>
        <property type="gene ID" value="ENSMICG00000007700.3"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:neuronal dense core vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
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        <property type="term" value="P:lipid catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:phosphatidylinositol metabolic process"/>
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        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
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        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
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        <property type="term" value="P:sensory perception of bitter taste"/>
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        <property type="entry name" value="C2 domain"/>
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        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
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        <property type="entry name" value="Phospholipase C beta, distal C-terminal domain"/>
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        <property type="entry name" value="C2_dom"/>
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        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
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    <dbReference type="InterPro" id="IPR016280">
        <property type="entry name" value="PLC-beta"/>
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    <dbReference type="InterPro" id="IPR028403">
        <property type="entry name" value="PLC-beta2_cat"/>
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    <dbReference type="InterPro" id="IPR014815">
        <property type="entry name" value="PLC-beta_C"/>
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    <dbReference type="InterPro" id="IPR042531">
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Chao H."/>
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                <person name="Doddapaneni H."/>
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                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
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                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
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                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cell membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUU1"/>
    <dbReference type="Ensembl" id="ENSMICT00000065182.1">
        <property type="protein sequence ID" value="ENSMICP00000041645.1"/>
        <property type="gene ID" value="ENSMICG00000044737.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153683"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15918">
        <property type="entry name" value="7tmA_OR1_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000082">
        <property type="entry name" value="Olfactory receptor 1A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48001">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 13" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0552">Olfaction</keyword>
    <keyword evidence="11 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="12 13" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="15">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="279" mass="30905" checksum="D63BB1605CC2A31F" modified="2022-01-19" version="1">ILLGLSRQPQQQQLLFVTDSRLHTPMYFFLGNLSFVDVSFSSNTTPKMLANHVLGIQTISFSGCLTQLYFLGVLASMDNFLLAVMAYDRFVAVCHPLHYTTKMTHQLCVLLVAGSWGVASLNALLHTLLMARLSFCADNIIPHFFCDVTPLLKLSCSDTHVNEMIILTEGSLIIVTPLVCILASYMHITCAVLRAPTIKGRWKAFSTCGSHLAVVFLFYGTIIAVYLNPLSSHSAEKDAAATVLYTVVTPMLNPFIYSLRNRDLKRALGKVVGWKTCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XY83</accession>
    <name>A0A8C5XY83_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004473">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XY83"/>
    <dbReference type="Ensembl" id="ENSMICT00000066689.1">
        <property type="protein sequence ID" value="ENSMICP00000043311.1"/>
        <property type="gene ID" value="ENSMICG00000028340.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016730"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026750">
        <property type="entry name" value="NTAN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498">
        <property type="entry name" value="N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12498:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL ASPARAGINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14736">
        <property type="entry name" value="N_Asn_amidohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="299" mass="33376" checksum="303789BAC60C6D9A" modified="2022-01-19" version="1">MLLLVEGLRVRLPQSAEDLVRAHQPPEERARLLRGQSVQQVGAQGLLYVQQRELAVTSPKDGSISILGSYDATTCHIVVLRHTSHTKAEVPLIMNSIKSFSDHAQGGRLELHLPPRWEASLLSDFDGQEEDIHLVTLCVTELNDREENENHFPVIYGIAVNVNTAEIYRAAFQDRGQEKQLRAARALTGGPMSSICDAKTEQLRIEPFSWVPFPHVDFWLQQDDKQILENFSTSPLAESPTHTHFVEHIRSTLMFLKKYPSPTNTLFPGSTALLYKINEDILLCCPGESAVASSSLTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZ35</accession>
    <name>A0A8C5XZ35_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SIX homeobox 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SIX5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SIX/Sine oculis homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026747">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616904.1">
        <property type="nucleotide sequence ID" value="XM_012761450.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZ35"/>
    <dbReference type="Ensembl" id="ENSMICT00000058503.1">
        <property type="protein sequence ID" value="ENSMICP00000043673.1"/>
        <property type="gene ID" value="ENSMICG00000042264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105869546"/>
    <dbReference type="KEGG" id="mmur:105869546"/>
    <dbReference type="CTD" id="147912"/>
    <dbReference type="GeneTree" id="ENSGT00940000162237"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160024">
        <property type="term" value="P:Leydig cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902723">
        <property type="term" value="P:negative regulation of skeletal muscle satellite cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000085">
        <property type="entry name" value="SIX homeobox 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031701">
        <property type="entry name" value="SIX1_SD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10390:SF40">
        <property type="entry name" value="HOMEOBOX PROTEIN SIX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16878">
        <property type="entry name" value="SIX1_SD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="209"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="250"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="393"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="67"/>
            <end position="81"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="737" mass="75021" checksum="3245D4C54985D720" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y0E7</accession>
    <name>A0A8C5Y0E7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024690">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y0E7"/>
    <dbReference type="Ensembl" id="ENSMICT00000046203.2">
        <property type="protein sequence ID" value="ENSMICP00000037707.1"/>
        <property type="gene ID" value="ENSMICG00000035901.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000064725.1">
        <property type="protein sequence ID" value="ENSMICP00000043784.1"/>
        <property type="gene ID" value="ENSMICG00000035901.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153120"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04984">
        <property type="entry name" value="IgV_L_lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000620">
        <property type="entry name" value="Immunoglobulin lambda locus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044680974" description="Ig-like domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="20"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="135" mass="14618" checksum="825483A2446C701A" modified="2022-01-19" version="1">MAWTPLLLPLLTLCTGAVSPYELTQPPSVSVTPGQTARIPCSGDKLDERYVHWYQQKPGKAPVLVIYEDSKRPSGIPERFSGSSSGNTAALTISGAQAGDEADYYCHVWDGSSNHLTVTQADGEVRHKPLSHLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y173</accession>
    <name>A0A8C5Y173_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03028544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y173"/>
    <dbReference type="Ensembl" id="ENSMICT00000065611.1">
        <property type="protein sequence ID" value="ENSMICP00000044595.1"/>
        <property type="gene ID" value="ENSMICG00000042330.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159364"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030719">
        <property type="term" value="P:P granule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034587">
        <property type="term" value="P:piRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tudor and KH domain containing"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
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    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050621">
        <property type="entry name" value="Tudor_domain_containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948:SF18">
        <property type="entry name" value="TUDOR AND KH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22948">
        <property type="entry name" value="TUDOR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="52"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="120"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="506" mass="55944" checksum="2C2D9A9A77A957AD" modified="2022-01-19" version="1">IAPLVFCWIQLEPIQLKNSLGLRLPASATVACILYRRYRGSREERLTFVREDDIEIEIGVPQEAVKLTTGRQGANIKQLRKQTGARIDVDTEDAVLLISGFPVQVCKAKAAIHQILTENTPVSEQLSVPQRSVGRIIGRGSEPIRSTCKASGAKITLAVAKNLILEKVSEDEELWKRIAHSVETRVRGKQPISVRRDEVAEPDGAGGPALWKTPVLAWKGGGDMAILGPKEGSWEKPNDDSIQNSGMPMFEIPGPDFSLLADEYLEVCVSAPEHPNHFWIQIIDSHSRQLDKLVNEMTQRYENSLLEDLTVHIGDIIAACLFTNAQVLGILENGNFDLYFVDFRDNGDCPLALRSDFLSLPFQCSLAQITPSGEQWEEEALDKFERLTHCTDWKPLVAKISSYVQTGISTWPKIYLHDTSNGKKLDIGLELVHKGYTLQFPEDVEENRAVPDMLKDVATKTDASLGTMLTETKKSPAEIAHALSCLSLSEAASMSGGDSLEDDCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4D9</accession>
    <name>A0A8C5Y4D9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">tRNA splicing endonuclease subunit 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSEN54</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019879">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634264.1">
        <property type="nucleotide sequence ID" value="XM_012778810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4D9"/>
    <dbReference type="Ensembl" id="ENSMICT00000065838.1">
        <property type="protein sequence ID" value="ENSMICP00000045346.1"/>
        <property type="gene ID" value="ENSMICG00000044012.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878940"/>
    <dbReference type="KEGG" id="mmur:105878940"/>
    <dbReference type="CTD" id="283989"/>
    <dbReference type="GeneTree" id="ENSGT00390000004214"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.150:FF:000001">
        <property type="entry name" value="tRNA splicing endonuclease subunit 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="5">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="509" mass="57363" checksum="43D119EACB0B640E" modified="2022-01-19" version="1">MEPEPEPAVVEVPAGRVLSARELLAARSRPQKLPQRSHGPKDFLPDGSAAQAERLRLCREELWQLLAEERVERLGSLVAAEWRPEEGSVELKSPAGKFWQTMGFSEQGRQRLHPEEALYLLECGSIQLFHQDLPLSIQEAYQLLLTEDTVTLLQYQVFSHLKRLGYVVRRFQPSCVLSPYERQLNLDGSTQCLEDRDGKRKRRGSSSRSINKKAKALENSLQPESLATSSPPPCRCPEEKPQLLESLGPCPGLAREGAGCSWESGQVGNGVQGARKLRWNFEQISFPNMASDSRHTLLLAPAPELLPANVAGRETDAESWCQKLNQRKEKLSRREQEQQAEARHFQEDINADPEVRRCSSWQEYKELLQRRHLQRSQNLPTHLWGQPVTPLLKPGQAASPAMVLQHISVLQTTHLADGGARLLERSEGLGISFDVYQADAVATFRKNNPGKPYARMCISGFDEPVPDLCSLKRLSYQSGDVPLIFALVDHGDISFYSFRDFTLPRDLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y5F6</accession>
    <name>A0A8C5Y5F6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TAFA chemokine like family member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TAFA3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAFA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002614">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y5F6"/>
    <dbReference type="Ensembl" id="ENSMICT00000061188.1">
        <property type="protein sequence ID" value="ENSMICP00000046471.1"/>
        <property type="gene ID" value="ENSMICG00000003208.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105878747"/>
    <dbReference type="CTD" id="284467"/>
    <dbReference type="GeneTree" id="ENSGT00940000155644"/>
    <dbReference type="OrthoDB" id="9924724at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903979">
        <property type="term" value="P:negative regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903980">
        <property type="term" value="P:positive regulation of microglial cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020350">
        <property type="entry name" value="Chemokine-like_TAFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051743">
        <property type="entry name" value="TAFA_chemokine-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31770">
        <property type="entry name" value="CHEMOKINE-LIKE PROTEIN TAFA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31770:SF3">
        <property type="entry name" value="CHEMOKINE-LIKE PROTEIN TAFA-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12020">
        <property type="entry name" value="TAFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150454" evidence="3">
        <location>
            <begin position="31"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="133" mass="14682" checksum="8D2BCBC1AA520306" modified="2022-01-19" version="1">MSERASRNWSTGGWLLALCLAWLWTRLATAASQPPTATVFVQQGTCEVIAAHRCCNRNRIEERSQTVKCSCFSGQVAGTTRAKPSCVDASIVLQRWWCQMEPCLPGEECKVLPDLSGWSCSSGQKVKTTKVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7F9</accession>
    <name>A0A8C5Y7F9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WD repeat domain-containing protein 83</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitogen-activated protein kinase organizer 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WDR83</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1. Identified in the spliceosome C complex. Interacts with PARD6B and CRB3. Interacts strongly with GTP-bound RRAGA but not with inactive GDP-bound. Interacts with p62/SQSTM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027788">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645952.1">
        <property type="nucleotide sequence ID" value="XM_012790498.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7F9"/>
    <dbReference type="Ensembl" id="ENSMICT00000062148.1">
        <property type="protein sequence ID" value="ENSMICP00000046547.1"/>
        <property type="gene ID" value="ENSMICG00000045845.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105885522"/>
    <dbReference type="KEGG" id="mmur:105885522"/>
    <dbReference type="CTD" id="84292"/>
    <dbReference type="GeneTree" id="ENSGT00940000159016"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060674">
        <property type="term" value="P:placenta blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001666">
        <property type="term" value="P:response to hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000273">
        <property type="entry name" value="WD repeat domain-containing protein 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="105"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="315" mass="34309" checksum="F2A728C2D644AE56" modified="2022-01-19" version="1">MAFPEPKPRGPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSNLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEAKDGISSVKVSDHEVLAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLGEYTGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGSLALALPVGRGVVQSLAYHPTEPCLLTAVGGSVHCWREEAYETEGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y857</accession>
    <name>A0A8C5Y857_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Sodium/potassium/calcium exchanger 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Na(+)/K(+)/Ca(2+)-exchange protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Solute carrier family 24 member 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">SLC24A5</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+). Involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium-calcium exchanger in melanocytes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(out) + K(+)(out) + 4 Na(+)(in) = Ca(2+)(in) + K(+)(in) + 4 Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:69967"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Melanosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619004.1">
        <property type="nucleotide sequence ID" value="XM_012763550.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y857"/>
    <dbReference type="Ensembl" id="ENSMICT00000065302.1">
        <property type="protein sequence ID" value="ENSMICP00000047748.1"/>
        <property type="gene ID" value="ENSMICG00000014499.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870740"/>
    <dbReference type="KEGG" id="mmur:105870740"/>
    <dbReference type="CTD" id="283652"/>
    <dbReference type="GeneTree" id="ENSGT01030000234532"/>
    <dbReference type="OrthoDB" id="2127281at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042470">
        <property type="term" value="C:melanosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048022">
        <property type="term" value="P:negative regulation of melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000009">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000015">
        <property type="entry name" value="sodium/potassium/calcium exchanger 5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00367">
        <property type="entry name" value="calcium/sodium antiporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="SODIUM/POTASSIUM/CALCIUM EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846:SF61">
        <property type="entry name" value="SODIUM_POTASSIUM_CALCIUM EXCHANGER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="6" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 26" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="19" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="12" id="KW-0769">Symport</keyword>
    <keyword evidence="9 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150484" description="Sodium/potassium/calcium exchanger 5" evidence="26">
        <location>
            <begin position="25"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="27">
        <location>
            <begin position="74"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="27">
        <location>
            <begin position="336"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00081356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00082809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="501" mass="55107" checksum="7DC219F5E6DED037" modified="2022-01-19" version="1">MQTKGGPKWTRRVLLLGILWTTTHLPLPGASLPQRLPRATENSTQCVISPSSEFPEGFFTKQERRDGGIIIYFLIILYMFLAVSVVCEEYFLPSLEIISESLGLSQDVAGATFMAAGSSAPELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNVVSTLSCWPLFRDCAAYAISVAAVLGIIFDNQVYWYEGTLLLLIYGLYVLVLCFDIKINQYIIKKCSPCCTCLAKALEERSEQQPLMGWEDEGQPFVRRQSRTDSGIFHEDSGYSQLSISLHGLSQISEDPPSVFNMPEADIKRIFWVLSLPIITLLFLTIPDCRKTFWKNYFVITFFMSALWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTISSVLVARKGKGDMAMSNIVGSNVFDMLCLGVPWFIKTAFMNASAPIEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDKKLGGVCLVLYLGLATLSILYELGIIGNNKIRGCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YB42</accession>
    <name>A0A8C5YB42_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Migration and invasion enhancer 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">MIEN1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with GPX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SelWTH family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020142">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621352.1">
        <property type="nucleotide sequence ID" value="XM_012765898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YB42"/>
    <dbReference type="Ensembl" id="ENSMICT00000060332.1">
        <property type="protein sequence ID" value="ENSMICP00000048487.1"/>
        <property type="gene ID" value="ENSMICG00000047201.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872101"/>
    <dbReference type="CTD" id="84299"/>
    <dbReference type="GeneTree" id="ENSGT00390000010440"/>
    <dbReference type="OrthoDB" id="5962009at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051491">
        <property type="term" value="P:positive regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000131">
        <property type="entry name" value="migration and invasion enhancer 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051441">
        <property type="entry name" value="SelW_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02174">
        <property type="entry name" value="CXXU_selWTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15124:SF27">
        <property type="entry name" value="MIGRATION AND INVASION ENHANCER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15124">
        <property type="entry name" value="SELENOPROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00065658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="115" mass="12311" checksum="F16A15A99F26D5FA" modified="2022-01-19" version="1">MSGEPGQLSVAPPPGEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRKASNGEPLEKITNSRPPCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YC54</accession>
    <name>A0A8C5YC54_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">APC membrane recruitment protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein FAM123A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">AMER2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Amer family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017853">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YC54"/>
    <dbReference type="Ensembl" id="ENSMICT00000068156.1">
        <property type="protein sequence ID" value="ENSMICP00000048359.1"/>
        <property type="gene ID" value="ENSMICG00000046626.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063529"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019003">
        <property type="entry name" value="AMER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22237:SF1">
        <property type="entry name" value="APC MEMBRANE RECRUITMENT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22237">
        <property type="entry name" value="APC MEMBRANE RECRUITMENT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09422">
        <property type="entry name" value="AMER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="323"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="548" mass="57093" checksum="35FFFB17F47B872F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YD89</accession>
    <name>A0A8C5YD89_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CUNH22orf15</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YD89"/>
    <dbReference type="Ensembl" id="ENSMICT00000068226.1">
        <property type="protein sequence ID" value="ENSMICP00000048815.1"/>
        <property type="gene ID" value="ENSMICG00000000746.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015147"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039471">
        <property type="entry name" value="CXorf65-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887:SF1">
        <property type="entry name" value="GENE 867-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33887">
        <property type="entry name" value="PB1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15874">
        <property type="entry name" value="Il2rg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="152" mass="16905" checksum="EAB3633CC8684A95" modified="2022-01-19" version="1">MFITVMFGAGCWELVNPWCNLVTLTSHLRQRGRVPPDATIALLAEDGHLVNLDEGLEEGVAPAESMASSLLQERGTYVLVQIIRGEGGAPTRYESLLENLDDQCPELAEELRWLSGLPRGQGRRRRLGTRRGHQEQGPPSRPRRDAPPKMPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEA7</accession>
    <name>A0A8C5YEA7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fc alpha and mu receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FCAMR</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03029919">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEA7"/>
    <dbReference type="Ensembl" id="ENSMICT00000066018.1">
        <property type="protein sequence ID" value="ENSMICP00000049486.1"/>
        <property type="gene ID" value="ENSMICG00000008397.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182977"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05716">
        <property type="entry name" value="IgV_pIgR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050671">
        <property type="entry name" value="CD300_family_receptors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860:SF49">
        <property type="entry name" value="HIGH AFFINITY IMMUNOGLOBULIN ALPHA AND IMMUNOGLOBULIN MU FC RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11860">
        <property type="entry name" value="POLYMERIC-IMMUNOGLOBULIN RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034044910" evidence="4">
        <location>
            <begin position="40"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin" evidence="5">
        <location>
            <begin position="76"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="223" mass="24507" checksum="B2F59F746465CE5B" modified="2022-01-19" version="1">ASFHIQCFLQVANQKAGWKVLLLLILCLLQGSSLSPAHGGPHLRWLLDGSLPSRTPSSPLCWRESSLAVANALKGPRLVSGKPGGAVTIQCHYAPSSVNRRQRKYWCRLGPPRWTCRTIVSSSRYTHYRYHGRVALADFPQRGFFVVRLSQLSLDDVGCYHCGIGDGSTMLFFSMNLTVSAVLYQRRAALSLPCWPHSCLRLWFCCRGSSGAGGPVSGHHGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGK2</accession>
    <name>A0A8C5YGK2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGK2"/>
    <dbReference type="Ensembl" id="ENSMICT00000068550.1">
        <property type="protein sequence ID" value="ENSMICP00000050424.1"/>
        <property type="gene ID" value="ENSMICG00000045714.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155953"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="151"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="37774" checksum="911077BA3A0A7566" modified="2022-01-19" version="1">TPPLLGDMSTGPIAESWCYTQVKVVKFSYMWTINNFSFCREEMGEVVNPKGLDDESKDYLSLYLLLVSCPKSEVRAKFKFSLLNAKREETKAMESQRAYRFVRDFLLDEMTSLHYFCEVSVVQDSVNISGHTNTNTLKVPECRLAERFRFTDCSFFVRGQEFKAHKSVLTARSPVFNAIKQKNRVEINDLDPEVFKEMMRFVYTGKAPNLDKMADNLLAAADKYALERLKVMCEEALCSNLSVENVADTLVLADLHSAEQLKAQAIDFINRCSVLRQLGCKDGKNWNSNQATDIMETAGWKSMIQSHPHLVARSLPSTCICNSVHSLAFHVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EFL4</accession>
    <name>A0A8C6EFL4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbonyl reductase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC105881306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EFL4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059186.1">
        <property type="protein sequence ID" value="ENSMICP00000041015.1"/>
        <property type="gene ID" value="ENSMICG00000043284.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000046499"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF4">
        <property type="entry name" value="CARBONYL REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="291" mass="31633" checksum="4B750024715834EC" modified="2022-01-19" version="1">MSSCSRVALVTGANKGIGFAIARDLCRQFSGDVVLTARDAVRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKNADTTPFHIQAEVTMKTNFFATRDVCTELLPLIKPQGECGGNSSPCLCPGPGPADSPCCGCTCLLVLSPACQAQFCCRTLSSLLWWLWVLSVLLVFAHLALLILQVSAQCLLREAVYLLCAPHTLQCSRMSPSPFLCSIRLILFRLVEPSLPPIQQALLKCVTCLEHSQSGLLPLYNKTDISRGCSSFSLNHLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EHJ4</accession>
    <name>A0A8C6EHJ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="6">1.3.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Synaptic glycoprotein SC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Trans-2,3-enoyl-CoA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">TECR</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway. Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-hexadecenoyl-CoA + NADPH + H(+) = hexadecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:36143"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:36144"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>(2E,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoA + NADPH + H(+) = (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:39331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:73856"/>
            <dbReference type="ChEBI" id="CHEBI:76416"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:39332"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2E,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + NADPH + H(+) = (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:39467"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:73870"/>
            <dbReference type="ChEBI" id="CHEBI:76461"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:39468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoA + NADPH + H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:39319"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:74264"/>
            <dbReference type="ChEBI" id="CHEBI:76412"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:39320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:14475"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>octadecanoyl-CoA + NADP(+) = (2E)-octadecenoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35351"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:71412"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:35353"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03027736">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613787.1">
        <property type="nucleotide sequence ID" value="XM_012758333.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EHJ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059667.1">
        <property type="protein sequence ID" value="ENSMICP00000043020.1"/>
        <property type="gene ID" value="ENSMICG00000009818.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867918"/>
    <dbReference type="CTD" id="9524"/>
    <dbReference type="GeneTree" id="ENSGT00950000182886"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17124">
        <property type="entry name" value="Ubl_TECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000083">
        <property type="entry name" value="Trans-2,3-enoyl-CoA reductase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049127">
        <property type="entry name" value="TECR-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF31">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21696">
        <property type="entry name" value="TECR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="19" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="9 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 30" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TECR-like N-terminal" evidence="32">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="31">
        <location>
            <begin position="155"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00050808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00057553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00072713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00078575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00081803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF21696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="308" mass="36008" checksum="B30AF014DBACC1B5" modified="2022-01-19" version="1">MKQYEVEILDAKTREKLCFLDKVEPQATIAEIKNLFTKSHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATFYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGHKYDFTSSRHTVVHLACICHSFHYVKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPSYGAQQVKLALAIFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAIMTQCLPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKP4</accession>
    <name>A0A8C6EKP4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Interferon-related developmental regulator 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nerve growth factor-inducible protein PC4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IFRD1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with PSIP1/LEDGF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591603.1">
        <property type="nucleotide sequence ID" value="XM_012736149.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591604.1">
        <property type="nucleotide sequence ID" value="XM_012736150.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKP4"/>
    <dbReference type="Ensembl" id="ENSMICT00000065475.1">
        <property type="protein sequence ID" value="ENSMICP00000048892.1"/>
        <property type="gene ID" value="ENSMICG00000047065.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105855269"/>
    <dbReference type="CTD" id="3475"/>
    <dbReference type="GeneTree" id="ENSGT00390000013347"/>
    <dbReference type="OrthoDB" id="686784at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000259">
        <property type="entry name" value="interferon-related developmental regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006921">
        <property type="entry name" value="Interferon-rel_develop_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF6">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04836">
        <property type="entry name" value="IFRD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="9">
        <location>
            <begin position="50"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Interferon-related developmental regulator C-terminal" evidence="8">
        <location>
            <begin position="392"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00068647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="451" mass="50300" checksum="BDCA0FB2377904C1" modified="2022-01-19" version="1">MPKNKKRNTPHRGGSGGGGGSGAATAAAATAGGQHRNVQPFSDEDASIETMSHCSGYSDPSSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGIKNALASKMLYEFILERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGIESEEILKTLGPVLKKIICDGTANIQARQTCATCFGVCCFIATDDITELYSTLECLENIFTKSYLKEKDTNVISSTPHTVLHISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLSCDDVNMRIAAGESLALLFELARGMESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDILRAVEERDFPTETIKFGPERMYIDCWVKKHTYDTFKEILGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMKISRFERHLYNSAAFKARTKARSKCRDKRADVGEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EM03</accession>
    <name>A0A8C6EM03_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein SGT1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Suppressor of G2 allele of SKP1 homolog</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EM03"/>
    <dbReference type="Ensembl" id="ENSMICT00000072929.1">
        <property type="protein sequence ID" value="ENSMICP00000051616.1"/>
        <property type="gene ID" value="ENSMICG00000048943.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000166099"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06489">
        <property type="entry name" value="p23_CS_hSgt1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000244">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="CS" evidence="17">
        <location>
            <begin position="141"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="275" mass="31356" checksum="550E2CD44C20F202" modified="2022-01-19" version="1">MAAAAAGPATTQRFFQSCSDALINEDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGNYCDPVADTKKSLELNPNNSTAMLRKGICEYHEKNYAAALETFTEGQKLYSTDADFSVWIKRCQEAQNGSESEVSTSQRTHQSKIKYDWYQTESQVIITLMIKNVQKNDVNVEFSAKELSALVKLPSGEDYNLKLRLLYPIIPEQSTFKVLSTKIEIKMKKPEAVRWEMLEGQGDVSKPKQFIADVKNLYPSSSHYTRNWDKLLNTKKNKKIRNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ES80</accession>
    <name>A0A8B7ES80_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">AP1G1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. In association with AFTPH/aftiphilin in the aftiphilin/p200/gamma-synergin complex, involved in the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <location evidence="4">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 14">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024120">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597983.2">
        <property type="nucleotide sequence ID" value="XM_012742529.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ES80"/>
    <dbReference type="Ensembl" id="ENSMICT00000001914.3">
        <property type="protein sequence ID" value="ENSMICP00000001746.2"/>
        <property type="gene ID" value="ENSMICG00000001912.3"/>
    </dbReference>
    <dbReference type="CTD" id="164"/>
    <dbReference type="GeneTree" id="ENSGT00950000182838"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035646">
        <property type="term" value="P:endosome to melanosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090160">
        <property type="term" value="P:Golgi to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043323">
        <property type="term" value="P:positive regulation of natural killer cell degranulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1230:FF:000002">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="16">
        <location>
            <begin position="705"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="596"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001746.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="825" mass="91781" checksum="A79BB2C404D8540B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EVW4</accession>
    <name>A0A8B7EVW4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sodium-coupled neutral amino acid transporter 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 38 member 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC38A7</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-asparagine(in) + Na(+)(in) = L-asparagine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:71383"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-glutamine(in) + Na(+)(in) = L-glutamine(out) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:68236"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with the mTORC1 complex; this interaction mediates the recruitment of mTORC1 to the lysosome and its subsequent activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599437.1">
        <property type="nucleotide sequence ID" value="XM_012743983.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599438.1">
        <property type="nucleotide sequence ID" value="XM_012743984.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599439.1">
        <property type="nucleotide sequence ID" value="XM_012743985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EVW4"/>
    <dbReference type="Ensembl" id="ENSMICT00000029191.2">
        <property type="protein sequence ID" value="ENSMICP00000022987.1"/>
        <property type="gene ID" value="ENSMICG00000016985.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859811"/>
    <dbReference type="KEGG" id="mmur:105859811"/>
    <dbReference type="CTD" id="55238"/>
    <dbReference type="GeneTree" id="ENSGT00940000158136"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140901">
        <property type="term" value="F:L-asparagine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140902">
        <property type="term" value="F:L-glutamine:sodium symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000038">
        <property type="entry name" value="Putative sodium-coupled neutral amino acid transporter 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF192">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0458">Lysosome</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="21">
        <location>
            <begin position="50"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00034241"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039331"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="463" mass="50007" checksum="8700CE96EECB0EB1" modified="2022-01-19" version="1">MAQLSINSDHGEWGLSTDAGERARLLQSPCVDTVPKSEWEPPPGGPGRGTTSTLGAVFIVVNACLGAGLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQASNERTYQEVVWAVCGKLTGVLCEVTIAIYTFGTCIAFLIIIGDQQDKIIAVMAKEPEGASGSPWYTDRKFTISLTAFLFILPLSIPREIGFQKYASFLSVVGTWYVTAIVIIKYIWPDKEMTPGDILTRPASWMAVFNAMPTICFGFQCHVSSVPVFNSMQRPEVKTWGGVVTAAMVIALAVYMGTGICGFLTFGAAVDPDVLLSYPSEDMAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYQGMPVEEDVGRERRRRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFIFVFPGLCLIQAKLSEMEEVKPASWWVLVSYGVLLVTLGAFIFGQTTANAIFVDLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EX21</accession>
    <name>A0A8B7EX21_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat and sterile alpha motif domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ANKS3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020837">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599098.1">
        <property type="nucleotide sequence ID" value="XM_012743644.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EX21"/>
    <dbReference type="Ensembl" id="ENSMICT00000015880.3">
        <property type="protein sequence ID" value="ENSMICP00000014473.3"/>
        <property type="gene ID" value="ENSMICG00000015881.3"/>
    </dbReference>
    <dbReference type="CTD" id="124401"/>
    <dbReference type="GeneTree" id="ENSGT00940000156610"/>
    <dbReference type="OMA" id="RKDVHTQ"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09519">
        <property type="entry name" value="SAM_ANKS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047238">
        <property type="entry name" value="ANKS3_SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF6">
        <property type="entry name" value="ANKYRIN REPEAT AND SAM DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="426"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014473.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="658" mass="72402" checksum="BECC6B594A1ED7E7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F0I5</accession>
    <name>A0A8B7F0I5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">exo-alpha-sialidase</fullName>
            <ecNumber evidence="3">3.2.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NEU3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alpha-(2-&gt;3)-, alpha-(2-&gt;6)-, alpha-(2-&gt;8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.</text>
            <dbReference type="EC" id="3.2.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03006518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600576.1">
        <property type="nucleotide sequence ID" value="XM_012745122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F0I5"/>
    <dbReference type="Ensembl" id="ENSMICT00000068537.1">
        <property type="protein sequence ID" value="ENSMICP00000045620.1"/>
        <property type="gene ID" value="ENSMICG00000046723.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105860390"/>
    <dbReference type="CTD" id="10825"/>
    <dbReference type="GeneTree" id="ENSGT00950000182944"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900186">
        <property type="term" value="P:negative regulation of clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.10:FF:000002">
        <property type="entry name" value="Neuraminidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF23">
        <property type="entry name" value="SIALIDASE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Sialidase" evidence="10">
        <location>
            <begin position="57"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="449" mass="50641" checksum="3422D1DB9145AB7A" modified="2022-01-19" version="1">MQANTWIWTHIELPPVLAEVMEEVTSCSFNSPLFQQEDKKGVTYRIPALLYVPPTHTLLAFAEKRSTGRDEDALYLVLRRGLRIGHSVQWGPLKPLMEATLPGHRTMNPCPVWEQKNGCVFLFFICVWDHVTERQQIMSGRNAARLCFICSQDAGCSWSEVRDLTEEVFGPEMKRWATFAVGPGHGVQLQSGRLVIPAYTYYIPYWFFCLRLPCIARSHSLMIYSDDLGVTWHRGSLIRPTVTGECQVAEVTGRAGHPVLYCSARTPNRHRAEAFSTNHGECFQRPALSRQLCEPRCGCQGSVVSFLPLGIPHRCQDPSGKDASTIQQSLLPEGSLRLEEEAGIPSESWLLYSHPVSKKQRVDLGIYLNQTPLEAACWSRPWILHCGPCGYSDLATLEEEGLFGCLFECGIKQECEQIAFRLFTDQEILSHVQEDCTSPGRNLSQFKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FFK4</accession>
    <name>A0A8B7FFK4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DENN domain containing 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">DENND2D</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012751681.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000046326.1"/>
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        <property type="entry name" value="DENN domain-containing protein 2A isoform X1"/>
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        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
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        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2D"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="55"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
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            <dbReference type="PROSITE" id="PS50211"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="471" mass="53762" checksum="BE7EA043A2C7AB27" modified="2022-01-19" version="1">MEGRVVGRVLRIFRHRPPWLRAGPPQDNPGEAVKEPERAQEYSLLNFAGGQHFFEYLVVVSLKKKHLGDDYEPTITYQFPKRENLLRGQQEEEERLLKAIPLFCFPDGNEWVPLTEYPRETFSFVLTNVDGSRKIGYCRRLLPAGPGPRLPKVYCIISCIGCFGLFSKILDEVEKRHQISMAVIYPFMQGLREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLLRCLSFEQILQIFASAVLERKIIFLAQGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLATVCCPTPFMVGVQMRFRQEVMDSPMEEVLLVNLCEGTFLLSVGDEKDILPPKLQEDILGSLGRGIDELKTSEEINEHVSGPFVQFFVKTVGHYASYIKREANGQGHFQERSFCKALTSKTNRRFVKKFVKTQLFSLFIQEAEKSKNPPEGYFQQKILEYEEQKKQKKPREKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FM44</accession>
    <name>A0A8B7FM44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-sensitive inward rectifier potassium channel 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inward rectifier K(+) channel Kir2.4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Potassium channel, inwardly rectifying subfamily J member 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">KCNJ14</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Membrane</location>
            <topology evidence="1 18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ14 subfamily.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609825.1">
        <property type="nucleotide sequence ID" value="XM_012754371.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FM44"/>
    <dbReference type="Ensembl" id="ENSMICT00000054585.2">
        <property type="protein sequence ID" value="ENSMICP00000018181.1"/>
        <property type="gene ID" value="ENSMICG00000029008.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105865641"/>
    <dbReference type="KEGG" id="mmur:105865641"/>
    <dbReference type="CTD" id="3770"/>
    <dbReference type="GeneTree" id="ENSGT01030000234586"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000063">
        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1400:FF:000001">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF40">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 18" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 18" id="KW-0813">Transport</keyword>
    <keyword evidence="5 18" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="21">
        <location>
            <begin position="51"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="22">
        <location>
            <begin position="196"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="398"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="17">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067113"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00080036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="434" mass="47671" checksum="E7B9FAB9DE7B8EFE" modified="2022-01-19" version="1">MGLARALRRLSGVLESGDSRAGDEEEAGPGLCRNGWAPALTPVGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPPAPCFSQVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSSSPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAERASQSPKSSFPGSLAAFCYENELALSCCQEEDEEEEAKEGNGMETDDGAGSPRVLTPTLALTLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FNW3</accession>
    <name>A0A8B7FNW3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein-glutamine gamma-glutamyltransferase</fullName>
            <ecNumber evidence="6">2.3.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">TGM3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:54816"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:14005"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:138370"/>
            <dbReference type="EC" id="2.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase superfamily. Transglutaminase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.13" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03021658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610464.1">
        <property type="nucleotide sequence ID" value="XM_012755010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FNW3"/>
    <dbReference type="Ensembl" id="ENSMICT00000003701.3">
        <property type="protein sequence ID" value="ENSMICP00000003371.2"/>
        <property type="gene ID" value="ENSMICG00000003703.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070354.1">
        <property type="protein sequence ID" value="ENSMICP00000042545.1"/>
        <property type="gene ID" value="ENSMICG00000003703.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865951"/>
    <dbReference type="KEGG" id="mmur:105865951"/>
    <dbReference type="CTD" id="7053"/>
    <dbReference type="GeneTree" id="ENSGT01050000244866"/>
    <dbReference type="OrthoDB" id="437511at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031234">
        <property type="term" value="C:extrinsic component of cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003810">
        <property type="term" value="F:protein-glutamine gamma-glutamyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000090">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000278">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.260.10:FF:000001">
        <property type="entry name" value="Protein-glutamine gamma-glutamyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000171">
        <property type="entry name" value="protein-glutamine gamma-glutamyltransferase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050779">
        <property type="entry name" value="Transglutaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023608">
        <property type="entry name" value="Transglutaminase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013808">
        <property type="entry name" value="Transglutaminase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008958">
        <property type="entry name" value="Transglutaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036238">
        <property type="entry name" value="Transglutaminase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001102">
        <property type="entry name" value="Transglutaminase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11590:SF36">
        <property type="entry name" value="PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00927">
        <property type="entry name" value="Transglut_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00868">
        <property type="entry name" value="Transglut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000459">
        <property type="entry name" value="TGM_EBP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49309">
        <property type="entry name" value="Transglutaminase, two C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00547">
        <property type="entry name" value="TRANSGLUTAMINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="10">
        <location>
            <begin position="265"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000459-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="693" mass="76911" checksum="6A8ABB074CBFA688" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FPF3</accession>
    <name>A0A8B7FPF3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">REM1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Interacts with Calmodulin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the small GTPase superfamily. RGK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021647">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610759.1">
        <property type="nucleotide sequence ID" value="XM_012755305.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610760.1">
        <property type="nucleotide sequence ID" value="XM_012755306.1"/>
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    <dbReference type="Ensembl" id="ENSMICT00000014666.3">
        <property type="protein sequence ID" value="ENSMICP00000013369.3"/>
        <property type="gene ID" value="ENSMICG00000014668.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866117"/>
    <dbReference type="KEGG" id="mmur:105866117"/>
    <dbReference type="CTD" id="28954"/>
    <dbReference type="GeneTree" id="ENSGT00940000160613"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030315">
        <property type="term" value="C:T-tubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005246">
        <property type="term" value="F:calcium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904878">
        <property type="term" value="P:negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014722">
        <property type="term" value="P:regulation of skeletal muscle contraction by calcium ion signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04148">
        <property type="entry name" value="RGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000311">
        <property type="entry name" value="GTP-binding protein RAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017358">
        <property type="entry name" value="RGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051641">
        <property type="entry name" value="RGK_GTP-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN REM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45775">
        <property type="entry name" value="RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038017">
        <property type="entry name" value="GTP-binding_GEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013369.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="300" mass="33311" checksum="BA738891927BBC54" modified="2022-01-19" version="1">MTLNTQQEAKTPLRRRASTPLSLSPRGRQPGLLSTAPSTQSQHPRLGQSASLNPPTQKPSPAPEDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHEQLGVAEDVYERTLTVDGEDTTLVVVDTWEAERLDKNWSQESCLEVGSAYVIVYSIADRGSFESASELRIQLRRTHQADHVPIILVGNKADLARCREVSVEEGRACAVVFDCKFIETSATLQHNVAELFEGVVRQLRLRRRDSAAREPPAPRRRVSLGQRARRLLERLTARSARRRALKARSKSCHNLAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FR65</accession>
    <name>A0A8B7FR65_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phosphoenolpyruvate carboxykinase [GTP], mitochondrial</fullName>
            <ecNumber evidence="6">4.1.1.32</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PCK2</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Can play an active role in glyceroneogenesis and gluconeogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:10389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03004360">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611426.1">
        <property type="nucleotide sequence ID" value="XM_012755972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FR65"/>
    <dbReference type="Ensembl" id="ENSMICT00000031380.2">
        <property type="protein sequence ID" value="ENSMICP00000039583.2"/>
        <property type="gene ID" value="ENSMICG00000001683.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866581"/>
    <dbReference type="KEGG" id="mmur:105866581"/>
    <dbReference type="CTD" id="5106"/>
    <dbReference type="GeneTree" id="ENSGT00390000001912"/>
    <dbReference type="OrthoDB" id="5841594at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071549">
        <property type="term" value="P:cellular response to dexamethasone stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071333">
        <property type="term" value="P:cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046327">
        <property type="term" value="P:glycerol biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070365">
        <property type="term" value="P:hepatocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160020">
        <property type="term" value="P:positive regulation of ferroptosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019543">
        <property type="term" value="P:propionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000005">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.228.20:FF:000006">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [GTP], mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000006">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000003">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase, cytosolic [GTP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003253">
        <property type="entry name" value="PRK04210.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561:SF11">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal" evidence="22">
        <location>
            <begin position="46"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoenolpyruvate carboxykinase C-terminal P-loop" evidence="21">
        <location>
            <begin position="278"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00056168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039583.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="640" mass="70520" checksum="C51B2416A2BB68A4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FS05</accession>
    <name>A0A8B7FS05_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">5-hydroxytryptamine receptor 3B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Serotonin receptor 3B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">HTR3B</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3A. The homomeric complex is not functional. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Postsynaptic cell membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611819.1">
        <property type="nucleotide sequence ID" value="XM_012756365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FS05"/>
    <dbReference type="Ensembl" id="ENSMICT00000010051.3">
        <property type="protein sequence ID" value="ENSMICP00000009156.3"/>
        <property type="gene ID" value="ENSMICG00000010056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866781"/>
    <dbReference type="KEGG" id="mmur:105866781"/>
    <dbReference type="CTD" id="9177"/>
    <dbReference type="GeneTree" id="ENSGT00940000158478"/>
    <dbReference type="OrthoDB" id="5975154at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904602">
        <property type="term" value="C:serotonin-activated cation-selective channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022850">
        <property type="term" value="F:serotonin-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098662">
        <property type="term" value="P:inorganic cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140227">
        <property type="term" value="P:serotonin-gated cation-selective signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19063">
        <property type="entry name" value="LGIC_TM_5-HT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000017">
        <property type="entry name" value="5-hydroxytryptamine receptor 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000056">
        <property type="entry name" value="5-hydroxytryptamine receptor 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008132">
        <property type="entry name" value="5HT3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008134">
        <property type="entry name" value="5HT3_rcpt_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049944">
        <property type="entry name" value="LGIC_TM_5-HT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01710">
        <property type="entry name" value="5HT3BRECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01708">
        <property type="entry name" value="5HT3RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133665" description="5-hydroxytryptamine receptor 3B" evidence="25">
        <location>
            <begin position="23"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="26">
        <location>
            <begin position="35"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="27">
        <location>
            <begin position="247"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00061125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00063036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009156.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="442" mass="49955" checksum="1FAA02B2D2B443EE" modified="2022-01-19" version="1">MLASVMAHLWPCILVAASGILAIDAPHPRNSVLHHLTKQLLQKYHKEVRPVHDWTETTTVYLDLFVHAVLDVDAKNQILKTSIWYREVWNDEFLSWNSSMFDEIREISLPLNAIWAPDIVINEFVDTERSPDLPYVYVNSSGTIKNSKPIQVVSACGLETYAFPFDIQNCSLTFNSILHTVEDVDLAFLRSREDIKHDKKMFLNDSEWELLSVSSAYSILQSSAGDFAQIQFNVVIRRHPLVYVVSLLIPSVFLMLVDLGSFYLPPDCRARIVFKTNVLVGYTVFKVNMSDEVPRNAGSVPLIGIFFTVCIAFLVLSLFKSILLVRFLHGERCSGQEWPLVCLQGDTEADGPAVDPRAQDAGVTGSPICQELQAPAGTLQEVWSQLHSINNHLRSQDQAHQEEVGWLALLYRLDQLLFRSYLVMLGLYTVTLCSLWALWSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FVT3</accession>
    <name>A0A8B7FVT3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Abhydrolase domain containing 12B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ABHD12B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613451.2">
        <property type="nucleotide sequence ID" value="XM_012757997.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FVT3"/>
    <dbReference type="Ensembl" id="ENSMICT00000059850.1">
        <property type="protein sequence ID" value="ENSMICP00000044966.1"/>
        <property type="gene ID" value="ENSMICG00000013597.3"/>
    </dbReference>
    <dbReference type="CTD" id="145447"/>
    <dbReference type="GeneTree" id="ENSGT00940000161597"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052651">
        <property type="term" value="P:monoacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF69">
        <property type="entry name" value="PROTEIN ABHD12B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="138"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="40152" checksum="4E39664C6F51D8E5" modified="2022-01-19" version="1">MDAQQCGAAAAPEPPARGCVAAWGDMVERNLRSVPHSCSTLGRKIADMYNSFTSKSLKEHIFPPLIEMLIYFNFFKAPFLVDLKRPESTIPHTVNFYVRAEPGVMLGVWHVVPSCRGQDAKGKDRCWYEAALRDGNPIIVYLHGSAQHRAASHRVKLAKVLSDGGFHVLCVDYRGFGDSTGKPTEEGLTVDAICIYEWTKARSGTTPVCLWGHSLGTGVATNAARVLEERGCPVDAIVLEAPFTNMWTASINYPLLKIYQKLPGFLRMLMDALRKDKIVFPSDENVKFLSSPLLILHGEDDNTVPLEYGKKVYEIAHNAYRNKERVKMVIFPPGYKHNLLCENPTLLITVRDFLSKQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G3J1</accession>
    <name>A0A8B7G3J1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Persulfide dioxygenase ETHE1, mitochondrial</fullName>
            <ecNumber evidence="13">1.13.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Hepatoma subtracted clone one protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sulfur dioxygenase ETHE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ETHE1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12981"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58905"/>
            <dbReference type="EC" id="1.13.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Monomer. Interacts with TST. May interact with RELA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.18" evidence="13"/>
    <dbReference type="EMBL" id="ABDC03026720">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616696.1">
        <property type="nucleotide sequence ID" value="XM_012761242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G3J1"/>
    <dbReference type="Ensembl" id="ENSMICT00000014638.3">
        <property type="protein sequence ID" value="ENSMICP00000013344.2"/>
        <property type="gene ID" value="ENSMICG00000014648.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869459"/>
    <dbReference type="KEGG" id="mmur:105869459"/>
    <dbReference type="CTD" id="23474"/>
    <dbReference type="GeneTree" id="ENSGT00940000159046"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000013">
        <property type="entry name" value="Persulfide dioxygenase ETHE1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="17">
        <location>
            <begin position="34"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00065219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013344.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="254" mass="27836" checksum="3A9E02A5E01172B7" modified="2022-01-19" version="1">MAGSAPGVVWRRLSRRAGTAAPVLLRQMFEPKSCTYTYLLGDRESREALLIDPVLETAARDARLVKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHLEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGLTVSTVEEERTLNPRLTLSCEEFVKVMDNLNLPKPLQIDIAVPANMRCGVQTPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKP6</accession>
    <name>A0A8B7GKP6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Glucosylceramidase</fullName>
            <ecNumber evidence="25">3.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">GBA1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70255"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:72956"/>
            <dbReference type="ChEBI" id="CHEBI:73432"/>
            <dbReference type="ChEBI" id="CHEBI:189066"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:70256"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:70257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-galactose</text>
            <dbReference type="Rhea" id="RHEA:14297"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:14298"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a beta-D-galactosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70235"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:18390"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189066"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:70236"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:70237"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + H2O = an N-acylsphing-4-enine + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:13269"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="3.2.1.45"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:13270"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:58264"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:58265"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:58266"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a beta-D-xylosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70239"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:70240"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>beta-D-glucosyl-(1&lt;-&gt;1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:70315"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:74450"/>
            <dbReference type="ChEBI" id="CHEBI:76302"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:70316"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:70317"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>beta-D-glucosyl-(1&lt;-&gt;1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70311"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:72961"/>
            <dbReference type="ChEBI" id="CHEBI:84719"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:70312"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="18">
            <dbReference type="Rhea" id="RHEA:70313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4E-enine + cholesterol = N-(9Z-octadecenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:58324"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:139140"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:58325"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:58326"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:70307"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:72956"/>
            <dbReference type="ChEBI" id="CHEBI:76297"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:70308"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:70309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside</text>
            <dbReference type="Rhea" id="RHEA:70303"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
            <dbReference type="ChEBI" id="CHEBI:45815"/>
            <dbReference type="ChEBI" id="CHEBI:65222"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:70304"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:70305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>beta-D-xylosyl-(1&lt;-&gt;1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:70251"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:77996"/>
            <dbReference type="ChEBI" id="CHEBI:189067"/>
            <dbReference type="ChEBI" id="CHEBI:189081"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:70252"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>cholesteryl 3-beta-D-glucoside + H2O = cholesterol + D-glucose</text>
            <dbReference type="Rhea" id="RHEA:11956"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16113"/>
            <dbReference type="ChEBI" id="CHEBI:17495"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:11957"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Steroid metabolism; cholesterol metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 25">Belongs to the glycosyl hydrolase 30 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.45" evidence="25"/>
    <dbReference type="EMBL" id="ABDC03003212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003213">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623305.1">
        <property type="nucleotide sequence ID" value="XM_012767851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKP6"/>
    <dbReference type="Ensembl" id="ENSMICT00000034910.2">
        <property type="protein sequence ID" value="ENSMICP00000023470.1"/>
        <property type="gene ID" value="ENSMICG00000011667.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873175"/>
    <dbReference type="KEGG" id="mmur:105873175"/>
    <dbReference type="CTD" id="2629"/>
    <dbReference type="GeneTree" id="ENSGT00390000009464"/>
    <dbReference type="OrthoDB" id="2160638at2759"/>
    <dbReference type="UniPathway" id="UPA00296"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004336">
        <property type="term" value="F:galactosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004348">
        <property type="term" value="F:glucosylceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046527">
        <property type="term" value="F:glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005124">
        <property type="term" value="F:scavenger receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905037">
        <property type="term" value="P:autophagosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048854">
        <property type="term" value="P:brain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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    </organism>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
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                <person name="Muzny D.M."/>
                <person name="Richards S."/>
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                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="Bbox2_TRIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13738">
        <property type="entry name" value="SPRY_PRY_TRIM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000056">
        <property type="entry name" value="Tripartite motif containing 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051051">
        <property type="entry name" value="E3_ubiq-ligase_TRIM/RNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044116">
        <property type="entry name" value="SPRY_PRY_TRIM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465">
        <property type="entry name" value="B-BOX DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25465:SF11">
        <property type="entry name" value="TRIPARTITE MOTIF CONTAINING 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="7">
        <location>
            <begin position="252"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="445" mass="50145" checksum="032FFBCA47EB3DC7" modified="2022-01-19" version="1">MAGAGQRSGVPGGPGPGEPEQVSGWRCPEHRDRVVELFCRRCRLCVCALCPVLGAHRGHPVCLALEEAMHVQKLSQECLKQLATKKQQEVGNITQIEDAEEKLKAHAESSKTWLTGKFSELRLLLDEEEVLAKKFIDKSTQLVLQMYREQAESCREQIDIINDLSNRVWSISQEPCPVQRLQAYTATEQEMQQQMCLGELCHPVPLSFEPVKSFFQGLVEAMRSTLQTPMDVRIKENMNCQLSGSSSTKPGTLLKISPSPERSLFLKYARTPSLEPDTMHARLRLSADRLTVRCGLLGRLGPAPAPQFDALWQVLGRDCFAAGRHYWEVDVQEAGAGWWVGAAYASLRRHGSSAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLHPREDPDRLGIFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGTISIPRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GUW2</accession>
    <name>A0A8B7GUW2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable RNA-binding protein 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">RNA-binding motif protein 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RBM18</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014853">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627244.1">
        <property type="nucleotide sequence ID" value="XM_012771790.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627245.1">
        <property type="nucleotide sequence ID" value="XM_012771791.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GUW2"/>
    <dbReference type="Ensembl" id="ENSMICT00000070468.1">
        <property type="protein sequence ID" value="ENSMICP00000045042.1"/>
        <property type="gene ID" value="ENSMICG00000046793.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105875148"/>
    <dbReference type="KEGG" id="mmur:105875148"/>
    <dbReference type="CTD" id="92400"/>
    <dbReference type="GeneTree" id="ENSGT00390000013765"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12355">
        <property type="entry name" value="RRM_RBM18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000185">
        <property type="entry name" value="Probable RNA-binding protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039157">
        <property type="entry name" value="RBM18_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="25"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="190" mass="21663" checksum="4E5DE52DAFA8EC42" modified="2022-01-19" version="1">MEAETKTLPLENASILSEGSLQEGHRLWIGNLDPKITEYHLLKLLQKFGKVKQFDFLFHKSGALEGQPRGYCFVNFETKQEAEQAIQCLNGKLALSKKLVVRWAHAQVKRYDHNKNDKILPISLEPSSSTEPTQSNLSVTAKIKAIEAKLKMMAENPDAEYPAAPVYSYFKPPEKKRTTPYSRTAWKSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GXA8</accession>
    <name>A0A8B7GXA8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex 11 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TCP11L2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009206">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628221.1">
        <property type="nucleotide sequence ID" value="XM_012772767.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GXA8"/>
    <dbReference type="Ensembl" id="ENSMICT00000008901.3">
        <property type="protein sequence ID" value="ENSMICP00000008106.2"/>
        <property type="gene ID" value="ENSMICG00000008898.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875611"/>
    <dbReference type="CTD" id="255394"/>
    <dbReference type="GeneTree" id="ENSGT00940000157835"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF17">
        <property type="entry name" value="T-COMPLEX PROTEIN 11-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008106.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="519" mass="58151" checksum="3A112A0CF0CF7446" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GXS2</accession>
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        <submittedName>
            <fullName evidence="3">Pancreatic progenitor cell differentiation and proliferation factor</fullName>
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        <name evidence="3" type="primary">PPDPF</name>
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    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPDPF family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628420.1">
        <property type="nucleotide sequence ID" value="XM_012772966.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GXS2"/>
    <dbReference type="Ensembl" id="ENSMICT00000005953.3">
        <property type="protein sequence ID" value="ENSMICP00000005430.2"/>
        <property type="gene ID" value="ENSMICG00000005959.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875742"/>
    <dbReference type="KEGG" id="mmur:105875742"/>
    <dbReference type="CTD" id="79144"/>
    <dbReference type="GeneTree" id="ENSGT00390000009113"/>
    <dbReference type="OrthoDB" id="9411431at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001889">
        <property type="term" value="P:liver development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026754">
        <property type="entry name" value="PPDPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14572">
        <property type="entry name" value="PANCREATIC PROGENITOR CELL DIFFERENTIATION AND PROLIFERATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPDFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02071">
        <property type="entry name" value="PPDPFACTOR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005430.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="112" mass="11422" checksum="C3FF85E6C8DDE883" modified="2022-01-19" version="1">MAAIPSGGSLVATHDYYRRRLGSASSSSSCGSAEGPGEAIPHPPGLPKADPGHWWASFFFGKSTLPFMTTVVESPEHSEAPQASRSVTTCGLAPAATRTQPCSPPGTAGPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H1M0</accession>
    <name>A0A8B7H1M0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450 family 2 subfamily F member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16 18" type="primary">CYP2F1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H1M0"/>
    <dbReference type="Ensembl" id="ENSMICT00000036256.2">
        <property type="protein sequence ID" value="ENSMICP00000032119.1"/>
        <property type="gene ID" value="ENSMICG00000031763.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000066515.1">
        <property type="protein sequence ID" value="ENSMICP00000040961.1"/>
        <property type="gene ID" value="ENSMICG00000031763.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876750"/>
    <dbReference type="KEGG" id="mmur:105876750"/>
    <dbReference type="CTD" id="1572"/>
    <dbReference type="VGNC" id="VGNC:80509">
        <property type="gene designation" value="CYP2F1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162522"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901170">
        <property type="term" value="P:naphthalene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20669">
        <property type="entry name" value="Cyp2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000001">
        <property type="entry name" value="Cytochrome P450, family 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020469">
        <property type="entry name" value="Cyt_P450_CYP2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF275">
        <property type="entry name" value="CYTOCHROME P450 2F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01957">
        <property type="entry name" value="EP450ICYP2F"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044664238" evidence="15">
        <location>
            <begin position="25"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="VGNC" id="VGNC:80509"/>
        </source>
    </evidence>
    <sequence length="491" mass="55684" checksum="777333F5189F2B69" modified="2022-01-19" version="1">MDSVSTAILLVLLALVCLFLTLSSRDKGRLPPGPRPFPLLGNLLQLHSQDMLTSLTKLSKEYGPVYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPIFFNFTKGNGIAFSNGDRWKVLRRFSVQILRNFGMGKRSIEERILEEGGFLLEELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGEMYNIFPSLLGWMPGPHRRVFQNFGDMKDLIAHIVRDHQASLDPTSPRDFIDCFLTKMAQEKQDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLVLMKYPKVQARVQEEIDHVVGRARLPALEDRAAMPYTDAVIHEVQRFADVIPMNLPHRVIRDTAFRGFLLPKGTDVITLLNTVHYDPSQFRTPREFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLSPLSSGLGNLPRPFQLSLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HK33</accession>
    <name>A0A8B7HK33_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="12">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">USP15</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">A homodimer structure has been reported; however it is unclear whether the protein form a homodimer in vivo. Identified in a complex with the COP9 signalosome complex (CSN). Interacts with SMAD1, SMAD2 and SMAD3; the interaction is direct. Forms a complex with SMURF2 and SMAD7. Interacts with TGFBR1. Interacts with SART3; the interaction is direct. May interact with RNF20 and RNF40. May interact with PRKN. Interacts with INCA1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03009741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637811.1">
        <property type="nucleotide sequence ID" value="XM_012782357.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HK33"/>
    <dbReference type="Ensembl" id="ENSMICT00000063760.1">
        <property type="protein sequence ID" value="ENSMICP00000046768.1"/>
        <property type="gene ID" value="ENSMICG00000000251.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880948"/>
    <dbReference type="KEGG" id="mmur:105880948"/>
    <dbReference type="CTD" id="9958"/>
    <dbReference type="GeneTree" id="ENSGT00940000154932"/>
    <dbReference type="OrthoDB" id="265776at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046332">
        <property type="term" value="F:SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005160">
        <property type="term" value="F:transforming growth factor beta receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061649">
        <property type="term" value="F:ubiquitin-modified histone reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035520">
        <property type="term" value="P:monoubiquitinated protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905035">
        <property type="term" value="P:negative regulation of antifungal innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030512">
        <property type="term" value="P:negative regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900246">
        <property type="term" value="P:positive regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990167">
        <property type="term" value="P:protein K27-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902238">
        <property type="term" value="P:regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2230.10:FF:000003">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000013">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000034">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000020">
        <property type="entry name" value="ubiquitin carboxyl-terminal hydrolase 15 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2230.10">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035927">
        <property type="entry name" value="DUSP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028135">
        <property type="entry name" value="Ub_USP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF28">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06337">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14836">
        <property type="entry name" value="Ubiquitin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00695">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143791">
        <property type="entry name" value="DUSP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 12" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUSP" evidence="15">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="14">
        <location>
            <begin position="289"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="635"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="952"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
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            <end position="673"/>
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            <end position="974"/>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062340"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="981" mass="112356" checksum="108FF48B33DA0CF9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HPS8</accession>
    <name>A0A8B7HPS8_MICMU</name>
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        <recommendedName>
            <fullName evidence="7">Nuclear factor related to kappa-B-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA-binding protein R kappa-B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">NFRKB</name>
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    <organism evidence="14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="14">Liver</tissue>
        </source>
    </reference>
    <reference evidence="12" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFRKB family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012783315.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000034268.1"/>
        <property type="gene ID" value="ENSMICG00000013865.3"/>
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        <property type="term" value="C:Ino80 complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protease binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of telomere maintenance in response to DNA damage"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of DNA strand elongation"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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        <property type="entry name" value="NFRKB_WH_1"/>
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        <property type="entry name" value="NFRKB_WH_2"/>
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        <property type="entry name" value="NFRKB_winged_sf"/>
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        <property type="entry name" value="NFRKB-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN"/>
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        <property type="entry name" value="WHD_1st_NFRKB"/>
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    </dbReference>
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        <property type="entry name" value="WHD_2nd_NFRKB"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
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            <begin position="39"/>
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        </location>
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            <begin position="166"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
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        <location>
            <begin position="216"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="723"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00059873"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060988"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070975"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076275"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034268.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RefSeq" id="XP_012638769.1"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRF2</accession>
    <name>A0A8B7HRF2_MICMU</name>
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        <recommendedName>
            <fullName evidence="12">Vacuolar protein sorting-associated protein 37A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ESCRT-I complex subunit VPS37A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">VPS37A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28 and HGS. Component of an ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, VPS37A and UBAP1 in a 1:1:1:1 stoichiometry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640453.1">
        <property type="nucleotide sequence ID" value="XM_012784999.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640454.1">
        <property type="nucleotide sequence ID" value="XM_012785000.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640455.1">
        <property type="nucleotide sequence ID" value="XM_012785001.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000061452.1">
        <property type="protein sequence ID" value="ENSMICP00000041692.1"/>
        <property type="gene ID" value="ENSMICG00000013504.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882527"/>
    <dbReference type="KEGG" id="mmur:105882527"/>
    <dbReference type="CTD" id="137492"/>
    <dbReference type="GeneTree" id="ENSGT00950000183012"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036258">
        <property type="term" value="P:multivesicular body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000069">
        <property type="entry name" value="vacuolar protein sorting-associated protein 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="16">
        <location>
            <begin position="309"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="398" mass="44289" checksum="BBAAB2A85DDB2F6B" modified="2022-01-19" version="1">MSWLFPLTKSASSSAAGSPGGLTSLQQQKQRLIESLRNSHSSIAEIQKDVEYRLPFTINNLTININILLPPQFPQEKPVISVYPPIRHHLMDKQGIYVTSPLVNNFTMHSDLGKIVQSLLDEFWKTPPVLAPTSTAFPYLYNNPGGMPPYAASQGFPFLPPFPPQEANRNITSLSVADTVSSSTTSFTTTKPAAPSFGVLSSLPLPVPTTDASAPTSQNGFGYKMPDVPDAFPELSELSVSQLTDMNEQEEILLEQFLTLPQLKKVITDKDDLVKSIEELARKNLLLEPSLEAKRQTVLDKYELLTQMKSAFEKKMQRQHELSESCSASALQARLKVAAHEAEEESDNIAEDFLEGKTEIDDFLSSFMEKRTICHCRRAKEEKLQQAIAMHSQFHAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HW16</accession>
    <name>A0A8B7HW16_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Golgi SNAP receptor complex member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">27 kDa Golgi SNARE protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Membrin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GOSR2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11 17">Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Golgi apparatus</location>
            <location evidence="12">cis-Golgi network membrane</location>
            <topology evidence="12">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 17">Belongs to the GOSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642305.1">
        <property type="nucleotide sequence ID" value="XM_012786851.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HW16"/>
    <dbReference type="Ensembl" id="ENSMICT00000066914.1">
        <property type="protein sequence ID" value="ENSMICP00000048306.1"/>
        <property type="gene ID" value="ENSMICG00000010683.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883606"/>
    <dbReference type="KEGG" id="mmur:105883606"/>
    <dbReference type="CTD" id="9570"/>
    <dbReference type="GeneTree" id="ENSGT00950000183192"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000044">
        <property type="entry name" value="Golgi SNAP receptor complex member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.400:FF:000004">
        <property type="entry name" value="Golgi SNAP receptor complex member 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 17" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="212" mass="24703" checksum="DA0C320FF45709A0" modified="2022-01-19" version="1">MEPLYQQTHKQVHEVQSHMGRLETADKQSLHLVENEIQASIDQIFSRLERLEILSSKEPPNKRQNAKLRVDQLKYDVQHLQTALRNFQHRRYAREQQERQREELLSRTFTTNDSDTTIPMDESLQFNSSLQKVHHGMDDLIGGGHSILEGLRAQRLTLKGTQKKILDIANMLGLSNTVMRLIEKRAFQDKYFMIGGMLLTCVVMFLVVQYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HZC6</accession>
    <name>A0A8B7HZC6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Otoferlin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Fer-1-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">OTOF</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Basolateral cell membrane</location>
            <topology evidence="19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cytoplasmic vesicle</location>
            <location evidence="21">Secretory vesicle</location>
            <location evidence="21">Synaptic vesicle membrane</location>
            <topology evidence="21">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Presynaptic cell membrane</location>
            <topology evidence="22">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ferlin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011910">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643630.1">
        <property type="nucleotide sequence ID" value="XM_012788176.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069433.1">
        <property type="protein sequence ID" value="ENSMICP00000045820.1"/>
        <property type="gene ID" value="ENSMICG00000006807.3"/>
    </dbReference>
    <dbReference type="CTD" id="9381"/>
    <dbReference type="GeneTree" id="ENSGT00940000155086"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035612">
        <property type="term" value="F:AP-2 adaptor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08373">
        <property type="entry name" value="C2A_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04011">
        <property type="entry name" value="C2B_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04018">
        <property type="entry name" value="C2C_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04017">
        <property type="entry name" value="C2D_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04037">
        <property type="entry name" value="C2E_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000009">
        <property type="entry name" value="dysferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000081">
        <property type="entry name" value="otoferlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000089">
        <property type="entry name" value="otoferlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000118">
        <property type="entry name" value="otoferlin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000034">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000054">
        <property type="entry name" value="otoferlin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037726">
        <property type="entry name" value="C2A_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037720">
        <property type="entry name" value="C2B_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037722">
        <property type="entry name" value="C2C_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037723">
        <property type="entry name" value="C2D_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037724">
        <property type="entry name" value="C2E_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012561">
        <property type="entry name" value="Ferlin_B-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055072">
        <property type="entry name" value="Ferlin_DSRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF32">
        <property type="entry name" value="OTOFERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22901">
        <property type="entry name" value="dsrm_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08150">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08151">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM01201">
        <property type="entry name" value="FerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1009">Hearing</keyword>
    <keyword evidence="16 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="13" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1965"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="236"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="400"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="944"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="1116"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="1465"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="27">
        <location>
            <begin position="1715"/>
            <end position="1866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="127"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="642"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1299"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1347"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="1315"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="25">
        <location>
            <begin position="1353"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1371"/>
            <end position="1384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00067393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00079078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1998" mass="227250" checksum="1B5906E7C49CF3D6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HZN9</accession>
    <name>A0A8B7HZN9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 35 member A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC35A5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001153">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642932.1">
        <property type="nucleotide sequence ID" value="XM_012787478.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HZN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000072697.1">
        <property type="protein sequence ID" value="ENSMICP00000051195.1"/>
        <property type="gene ID" value="ENSMICG00000049390.1"/>
    </dbReference>
    <dbReference type="CTD" id="55032"/>
    <dbReference type="GeneTree" id="ENSGT00950000182827"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="454" mass="52057" checksum="38162C267E9FD4B9" modified="2022-01-19" version="1">MVLALCLIFRSDNRVTHEVFFSLRQLKSSGMERKCCSLSMLCSLSTMYTFLLGAIFIALSSSRILLVKYSANEENKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKDDQSRNLKCASWEEFCNFMKWSIPAFLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRHLNWIQWASLLILFLSIVSLTAGTKTSQHNLVGHGFHHDAFFSPSNSCLLFRNECPRKDNCTAKEWTFPEAKWNTTARVFSHIRLGLGHVLIIVQCFISSMANIYNEKILKEGNQLTESIFIQNSKLYFFGILFNGLTLGLQRSNRDQIKNCGFFYGHNAFSVALIFITAFQGLSVAFILKFLDNMFHVLMAQITTVIITTVSVLVFDFRPSLEFFLEAPSVLLSIFIYNASKPQRLEYAPRQERMRDLSGILWERSSGDGEELERLTKPKSDESDEDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I154</accession>
    <name>A0A8B7I154_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">DNA polymerase subunit gamma-1</fullName>
            <ecNumber evidence="4 18">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">POLG</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of DNA polymerase gamma solely responsible for replication of mitochondrial DNA (mtDNA). Replicates both heavy and light strands of the circular mtDNA genome using a single-stranded DNA template, RNA primers and the four deoxyribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 3'-end 2'-deoxyribonucleotidyl-deoxyribonucleotide-DNA + H2O = a 3'-end 2'-deoxyribonucleotide-DNA + a 2'-deoxyribonucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77911"/>
            <dbReference type="Rhea" id="RHEA-COMP:13863"/>
            <dbReference type="Rhea" id="RHEA-COMP:19009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="ChEBI" id="CHEBI:138148"/>
            <dbReference type="ChEBI" id="CHEBI:228185"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:77912"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:76256"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Heterotrimer composed of a catalytic subunit and a homodimer of accessory subunits (POLG:POLG2). Interacts with TTC3. Interacts with LIG3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
            <location evidence="2">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4 18"/>
    <dbReference type="EMBL" id="ABDC03013693">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644340.1">
        <property type="nucleotide sequence ID" value="XM_012788886.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644341.1">
        <property type="nucleotide sequence ID" value="XM_012788887.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644342.1">
        <property type="nucleotide sequence ID" value="XM_012788888.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644343.1">
        <property type="nucleotide sequence ID" value="XM_012788889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I154"/>
    <dbReference type="Ensembl" id="ENSMICT00000001955.3">
        <property type="protein sequence ID" value="ENSMICP00000001785.3"/>
        <property type="gene ID" value="ENSMICG00000001951.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105884713"/>
    <dbReference type="CTD" id="5428"/>
    <dbReference type="GeneTree" id="ENSGT00390000000453"/>
    <dbReference type="OrthoDB" id="5588663at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051575">
        <property type="term" value="F:5'-deoxyribose-5-phosphate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:protease binding"/>
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    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
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        <property type="term" value="P:mitochondrial DNA replication"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="DNA_pol_gammaA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase gamma, catalytic subunit"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
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    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047580">
        <property type="entry name" value="POLG_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000797">
        <property type="entry name" value="DNA_pol_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 18" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="7 18" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family A palm" evidence="21">
        <location>
            <begin position="852"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="479"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="697"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001785.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1214" mass="136574" checksum="3D5BC62D3FCB2848" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I580</accession>
    <name>A0A8B7I580_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Angiopoietin like 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ANGPTL8</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027827">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012790599.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000064853.1">
        <property type="protein sequence ID" value="ENSMICP00000049076.1"/>
        <property type="gene ID" value="ENSMICG00000042533.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885569"/>
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    <dbReference type="GeneTree" id="ENSGT00440000034383"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045444">
        <property type="term" value="P:fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010954">
        <property type="term" value="P:positive regulation of protein processing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050746">
        <property type="term" value="P:regulation of lipoprotein metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070328">
        <property type="term" value="P:triglyceride homeostasis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026614">
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        <property type="entry name" value="ANGIOPOIETIN-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21463:SF0">
        <property type="entry name" value="ANGIOPOIETIN-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134239" evidence="1">
        <location>
            <begin position="19"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="198" mass="21901" checksum="215A978815CB27CB" modified="2022-01-19" version="1">MPLLALCLLWALAPVARPAPAAPEGSLEPAEHEELTLLFHGTLQLSQALNGVYRATEARLTEAGRNLGLYGYTLGLLGQDISRGRDAAQELRASLLQTQAEEEILQLHAEATAQVLGEVAQEQQLLWDNVRQLEVQLRGAGLGRARQEFEALKAHADKQSHVVWALTGHVQRQRREMAAQQHRLRKIQERLHTAALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I5K6</accession>
    <name>A0A8B7I5K6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Carnitine O-palmitoyltransferase 1, liver isoform</fullName>
            <ecNumber evidence="4">2.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carnitine O-palmitoyltransferase 1, muscle isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Carnitine O-palmitoyltransferase I, liver isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Carnitine O-palmitoyltransferase I, muscle isoform</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Carnitine palmitoyltransferase 1A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Carnitine palmitoyltransferase 1B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Succinyltransferase CPT1A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">CPT1B</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(R)-carnitine + hexadecanoyl-CoA = O-hexadecanoyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:12661"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:17490"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="2.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:12662"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>succinyl-CoA + L-lysyl-[protein] = N(6)-succinyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16261"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homohexamer and homotrimer. Identified in a complex that contains at least CPT1A, ACSL1 and VDAC1. Also identified in complexes with ACSL1 and VDAC2 and VDAC3. Interacts with ZDHHC4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 27">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03009109">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644953.1">
        <property type="nucleotide sequence ID" value="XM_012789499.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644955.1">
        <property type="nucleotide sequence ID" value="XM_012789501.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I5K6"/>
    <dbReference type="Ensembl" id="ENSMICT00000049361.2">
        <property type="protein sequence ID" value="ENSMICP00000030599.2"/>
        <property type="gene ID" value="ENSMICG00000000856.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884997"/>
    <dbReference type="KEGG" id="mmur:105884997"/>
    <dbReference type="CTD" id="1375"/>
    <dbReference type="GeneTree" id="ENSGT01150000286917"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004095">
        <property type="term" value="F:carnitine O-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006853">
        <property type="term" value="P:carnitine shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000001">
        <property type="entry name" value="Carnitine O-palmitoyltransferase 1, liver isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000042">
        <property type="entry name" value="Carnitine Palmitoyl Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032476">
        <property type="entry name" value="CPT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF69">
        <property type="entry name" value="CARNITINE O-PALMITOYLTRANSFERASE 1, MUSCLE ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16484">
        <property type="entry name" value="CPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00439">
        <property type="entry name" value="ACYLTRANSF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 27" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 27" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carnitine O-palmitoyltransferase N-terminal" evidence="29">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="28">
        <location>
            <begin position="176"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="26">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00067106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00078897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00081709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00084056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF16484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030599.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="772" mass="88324" checksum="8807882164B185F5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WL03</accession>
    <name>A0A8B7WL03_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycerate kinase</fullName>
            <ecNumber evidence="3">2.7.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GLYCTK</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-glycerate + ATP = (2R)-3-phosphoglycerate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16659"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerate kinase type-2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.31" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03018255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626964.1">
        <property type="nucleotide sequence ID" value="XM_012771510.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626965.1">
        <property type="nucleotide sequence ID" value="XM_012771511.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626966.1">
        <property type="nucleotide sequence ID" value="XM_012771512.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135957.1">
        <property type="nucleotide sequence ID" value="XM_020280368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WL03"/>
    <dbReference type="Ensembl" id="ENSMICT00000030753.2">
        <property type="protein sequence ID" value="ENSMICP00000027118.1"/>
        <property type="gene ID" value="ENSMICG00000030257.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875042"/>
    <dbReference type="KEGG" id="mmur:105875042"/>
    <dbReference type="CTD" id="132158"/>
    <dbReference type="GeneTree" id="ENSGT00390000014365"/>
    <dbReference type="OrthoDB" id="44918at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008887">
        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10180:FF:000001">
        <property type="entry name" value="Glycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10180">
        <property type="entry name" value="Glycerate kinase, MOFRL-like N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1480.10">
        <property type="entry name" value="MOFRL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037035">
        <property type="entry name" value="GK-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038614">
        <property type="entry name" value="GK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007835">
        <property type="entry name" value="MOFRL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025286">
        <property type="entry name" value="MOFRL_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039760">
        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12227:SF0">
        <property type="entry name" value="GLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13660">
        <property type="entry name" value="DUF4147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05161">
        <property type="entry name" value="MOFRL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82544">
        <property type="entry name" value="GckA/TtuD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOFRL-associated" evidence="10">
        <location>
            <begin position="38"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="MOFRL" evidence="9">
        <location>
            <begin position="402"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="523" mass="54850" checksum="F86FE01F5896ED1A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X8J8</accession>
    <name>A0A8B7X8J8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formiminotransferase N-terminal subdomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC105856988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03010927">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594543.1">
        <property type="nucleotide sequence ID" value="XM_012739089.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594544.1">
        <property type="nucleotide sequence ID" value="XM_012739090.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594545.1">
        <property type="nucleotide sequence ID" value="XM_012739091.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594546.1">
        <property type="nucleotide sequence ID" value="XM_012739092.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143874.1">
        <property type="nucleotide sequence ID" value="XM_020288285.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143875.1">
        <property type="nucleotide sequence ID" value="XM_020288286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X8J8"/>
    <dbReference type="Ensembl" id="ENSMICT00000031950.2">
        <property type="protein sequence ID" value="ENSMICP00000025343.1"/>
        <property type="gene ID" value="ENSMICG00000026608.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856988"/>
    <dbReference type="KEGG" id="mmur:105856988"/>
    <dbReference type="CTD" id="348751"/>
    <dbReference type="GeneTree" id="ENSGT00390000005581"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005542">
        <property type="term" value="F:folic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.670">
        <property type="entry name" value="Formiminotransferase, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.990.10">
        <property type="entry name" value="Formiminotransferase, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037070">
        <property type="entry name" value="Formiminotransferase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012886">
        <property type="entry name" value="Formiminotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037064">
        <property type="entry name" value="Formiminotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022384">
        <property type="entry name" value="FormiminoTrfase_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051623">
        <property type="entry name" value="FTCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234:SF1">
        <property type="entry name" value="FORMIMINOTRANSFERASE N-TERMINAL SUBDOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12234">
        <property type="entry name" value="FORMIMINOTRANSFERASE-CYCLODEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07837">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01222">
        <property type="entry name" value="FTCD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55116">
        <property type="entry name" value="Formiminotransferase domain of formiminotransferase-cyclodeaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formiminotransferase N-terminal subdomain" evidence="1">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="35198" checksum="268A38736607709D" modified="2022-01-19" version="1">MSSLGLRLAACLLNISEARRKYIVENIAKAALLDKNGQKLSEVTVLNIFSDQDYNRSVITIAASVDKLGSAVLSACLEAFRAIDMEVQEGIHPCLGAVDLIPIYPLSGVGVEECGVVARSLAESLVRHVPGCSVFLFGEADLPEKRSLVQRRKQLGWFTRRDFSVLQPDLGAAPARRCGLTGVGASPYVMNCNVTIDSQDLSAGREIASVIRGSGANGLKGVQTMAFPHEGKIEIACNVESFEDQEATEISQVSQYMTYSVLGNHFSYVSPHYIEAQVKKLAGDRGIGTIGGALVGFTPQECKDCAEYAIKENIGEFWKIRGGVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XCG4</accession>
    <name>A0A8B7XCG4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HECW1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
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        <text evidence="3">Protein modification; protein ubiquitination.</text>
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        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
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        <property type="protein sequence ID" value="ENSMICP00000000965.3"/>
        <property type="gene ID" value="ENSMICG00000001053.3"/>
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        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:regulation of dendrite morphogenesis"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="C2_NEDL1-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000002">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.90.1750.10:FF:000036">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.20.70.10:FF:000007">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
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    </dbReference>
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        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
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    <dbReference type="FunFam" id="3.30.2160.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
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    <dbReference type="FunFam" id="3.90.1750.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HECW2 isoform X1"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000048">
        <property type="entry name" value="HECT, C2 and WW domain-containing E3 ubiquitin protein ligase 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000035">
        <property type="entry name" value="LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECW2"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
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        <property type="entry name" value="C2_HECW"/>
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    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
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        <property type="entry name" value="HECT_dom"/>
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        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECW1"/>
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        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
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        <property type="entry name" value="WW"/>
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        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
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        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0833">Ubl conjugation pathway</keyword>
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            <begin position="182"/>
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    </feature>
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            <begin position="824"/>
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    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="1013"/>
            <end position="1046"/>
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    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="1266"/>
            <end position="1601"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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    <feature type="region of interest" description="Disordered" evidence="12">
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    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="12">
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            <begin position="889"/>
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        <location>
            <begin position="354"/>
            <end position="374"/>
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        <location>
            <begin position="418"/>
            <end position="445"/>
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        <location>
            <begin position="502"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="579"/>
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            <begin position="589"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
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        <source>
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    <sequence length="1601" mass="178171" checksum="2A52E42E051F9FA1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
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        <name evidence="7" type="primary">TBPL2</name>
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        <name type="scientific">Microcebus murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
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    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="73"/>
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        </location>
    </feature>
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        <location>
            <begin position="121"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000854.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="373" mass="41236" checksum="D41500F4FB243627" modified="2022-01-19" version="1">MPSAPLRPSRPLARGCLLTGPSPTPTAGPLPMDEETYLELYLDQCAVQDDLVPPRSPLFSPVVPYVYTPHPSNPETTFNSHHESKETSGDFSSVDLSFLPDELTQENKDQAVIRSKHEIEENCEAQSQQSRLPLPSGQDVGPSLDSSSLSNSHSHLHLGDADSIQSSPEKPNSNSLPLASITPMTPMTPVSECCGIVPQLQNIVSTVNLACKLDLKKIALHAKNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPARFLDFKIQNMVGSCDVRFSIRLEGLVLTHQQFSSYEPELFPGLIYRMVKPRIVLLIFVSGKVVLTGAKERSEIYEAFENIYPILKGFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UN45</accession>
    <name>A0A8C5UN45_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large proline-rich protein BAG6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">BCL2-associated athanogene 6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">HLA-B-associated transcript 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">BAG6</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).</text>
    </comment>
    <comment type="function">
        <text evidence="1">Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="22">Component of the BAG6/BAT3 complex, also named BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35. Interacts with GET4; the interaction is direct and localizes BAG6 in the cytosol. Interacts with UBL4A; the interaction is direct and required for UBL4A protein stability. Interacts with AIFM1. Interacts with HSPA2. Interacts with CTCFL. Interacts with p300/EP300. Interacts (via ubiquitin-like domain) with RNF126; required for BAG6-dependent ubiquitination of proteins mislocalized to the cytosol. Interacts (via ubiquitin-like domain) with SGTA; SGTA competes with RNF126 by binding the same region of BAG6, thereby promoting deubiquitination of BAG6-target proteins and rescuing them from degradation. Interacts with ricin A chain. Interacts with VCP and AMFR; both form the VCP/p97-AMFR/gp78 complex. Interacts with SYVN1. Interacts with USP13; the interaction is direct and may mediate UBL4A deubiquitination. Interacts with ZFAND2B. Interacts with KPNA2. Interacts with UBQLN4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular exosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UN45"/>
    <dbReference type="Ensembl" id="ENSMICT00000003645.3">
        <property type="protein sequence ID" value="ENSMICP00000003318.3"/>
        <property type="gene ID" value="ENSMICG00000003629.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016199"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01809">
        <property type="entry name" value="Ubl_BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000041">
        <property type="entry name" value="large proline-rich protein BAG6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021925">
        <property type="entry name" value="BAG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048926">
        <property type="entry name" value="Bag6_BAGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12057">
        <property type="entry name" value="BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20960">
        <property type="entry name" value="Bag6_BAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="13" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0391">Immunity</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="24">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
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        </location>
    </feature>
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            <begin position="95"/>
            <end position="108"/>
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    </feature>
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        <location>
            <begin position="211"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
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            <begin position="222"/>
            <end position="237"/>
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        <location>
            <begin position="245"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="388"/>
            <end position="402"/>
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    </feature>
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        <location>
            <begin position="403"/>
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    </feature>
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        <location>
            <begin position="424"/>
            <end position="433"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="1001"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1081"/>
            <end position="1108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00029739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00046003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00046936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003318.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1128" mass="119088" checksum="687E7ED97CAE149C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTP3</accession>
    <name>A0A8C5UTP3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SH3 domain binding glutamate rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SH3BGR</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033209">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033213">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033215">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033217">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033218">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UTP3"/>
    <dbReference type="Ensembl" id="ENSMICT00000007753.3">
        <property type="protein sequence ID" value="ENSMICP00000007055.3"/>
        <property type="gene ID" value="ENSMICG00000007755.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159847"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF1">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007055.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="125" mass="13498" checksum="45C6CB5BF000BACA" modified="2022-01-19" version="1">MRENVPGEKKPQNGIPLPPQIFNEEQYCGDFDSFFSAKEENIIYSFLGLAPPPGSKGTEKGGDSGENEAQKADGEDAGNLPGPQKEEEGETATEETEEITEEGEGGEDEEEEAEEEEPGEEGEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWC9</accession>
    <name>A0A8C5UWC9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Copine-7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Copine VII</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CPNE7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copine family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023248">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138418.1">
        <property type="nucleotide sequence ID" value="XM_020282829.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138419.1">
        <property type="nucleotide sequence ID" value="XM_020282830.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UWC9"/>
    <dbReference type="Ensembl" id="ENSMICT00000008197.3">
        <property type="protein sequence ID" value="ENSMICP00000007469.3"/>
        <property type="gene ID" value="ENSMICG00000008194.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855946"/>
    <dbReference type="KEGG" id="mmur:105855946"/>
    <dbReference type="CTD" id="27132"/>
    <dbReference type="GeneTree" id="ENSGT00940000160442"/>
    <dbReference type="OrthoDB" id="5855668at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04048">
        <property type="entry name" value="C2A_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04047">
        <property type="entry name" value="C2B_Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01459">
        <property type="entry name" value="vWA_copine_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000042">
        <property type="entry name" value="Copine 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000132">
        <property type="entry name" value="Copine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000163">
        <property type="entry name" value="Copine 7"/>
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    <dbReference type="InterPro" id="IPR045052">
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        <property type="entry name" value="Copine_C"/>
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        <property type="entry name" value="COPINE-7"/>
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    </dbReference>
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        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07002">
        <property type="entry name" value="Copine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="137"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="16">
        <location>
            <begin position="307"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009048"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007469.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="558" mass="62135" checksum="D1854E3A6E29567E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">AKNA domain containing 1</fullName>
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    </protein>
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        <name evidence="3" type="primary">AKNAD1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03002895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UWM6"/>
    <dbReference type="Ensembl" id="ENSMICT00000008393.3">
        <property type="protein sequence ID" value="ENSMICP00000007643.3"/>
        <property type="gene ID" value="ENSMICG00000008391.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154254"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052655">
        <property type="entry name" value="AKNA_Centrosome-Trans_reg"/>
    </dbReference>
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        <property type="entry name" value="AKNA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21510">
        <property type="entry name" value="AKNA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21510:SF16">
        <property type="entry name" value="PROTEIN AKNAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12443">
        <property type="entry name" value="AKNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="321"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="722"/>
        </location>
    </feature>
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        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007643.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="811" mass="89998" checksum="C643B3634A98902E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXZ0</accession>
    <name>A0A8C5UXZ0_MICMU</name>
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        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03023417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023418">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023419">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXZ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000011197.3">
        <property type="protein sequence ID" value="ENSMICP00000010197.3"/>
        <property type="gene ID" value="ENSMICG00000011194.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156519"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030521">
        <property type="term" value="P:androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044381">
        <property type="term" value="P:glucose import in response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009895">
        <property type="term" value="P:negative regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030859">
        <property type="term" value="P:polarized epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010828">
        <property type="term" value="P:positive regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010718">
        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050847">
        <property type="term" value="P:progesterone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902044">
        <property type="term" value="P:regulation of Fas signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150106">
        <property type="term" value="P:regulation of protein localization to cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903076">
        <property type="term" value="P:regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="160"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010197.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="327" mass="37296" checksum="C6DA5741B7394603" modified="2022-01-19" version="1">MQPSGHRLRDVEHHPLLTENDNYDSSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVVYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPVSAPHACSPRPTHCGHGPLVCNLSQGTVKVDTYVLLQNIHSNFPPPWLLLWFQNQTLLFSICKDVFEKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGVLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPMRPRKGGPEFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UYE1</accession>
    <name>A0A8C5UYE1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">R3H domain containing like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">R3HDML</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UYE1"/>
    <dbReference type="Ensembl" id="ENSMICT00000008233.3">
        <property type="protein sequence ID" value="ENSMICP00000007501.3"/>
        <property type="gene ID" value="ENSMICG00000008238.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161086"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000003">
        <property type="entry name" value="Peptidase inhibitor 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034871052" evidence="7">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="8">
        <location>
            <begin position="58"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007501.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="238" mass="26248" checksum="777D93D06D8ED00D" modified="2022-01-19" version="1">MPLLPGAMGLAGLLFWAGQTADALKMPNATLPLAWPESTALWPLSGLAVPRKCHISAWDMSALLDYHTRISASVHPPAANMEYMVWDERLARSAEAWATQCTWAHGPSQLMRYVGQNLSIHSGQYRSVVDIVKAWSEEKQHYLFPAPKDCDPHCPWHCRGSACSHYTQISSVGLGCAIHTCSSVSVGGSTWHQAVYLVCNYAIKGHWIGEAPYKLGRPCSACPPSYQAICNSNMFLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V048</accession>
    <name>A0A8C5V048_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor binding to IGHM enhancer 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TFE3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MiT/TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593575.1">
        <property type="nucleotide sequence ID" value="XM_012738121.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V048"/>
    <dbReference type="Ensembl" id="ENSMICT00000009704.3">
        <property type="protein sequence ID" value="ENSMICP00000008835.2"/>
        <property type="gene ID" value="ENSMICG00000009708.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856409"/>
    <dbReference type="CTD" id="7030"/>
    <dbReference type="GeneTree" id="ENSGT00940000157503"/>
    <dbReference type="OrthoDB" id="6242697at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045785">
        <property type="term" value="P:positive regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045670">
        <property type="term" value="P:regulation of osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18928">
        <property type="entry name" value="bHLHzip_TFE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000003">
        <property type="entry name" value="microphthalmia-associated transcription factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024100">
        <property type="entry name" value="bHLHzip_TFE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021802">
        <property type="entry name" value="MiT/TFE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031867">
        <property type="entry name" value="MiT/TFE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776">
        <property type="entry name" value="MIP04163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45776:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11851">
        <property type="entry name" value="DUF3371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15951">
        <property type="entry name" value="MITF_TFEB_C_3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="11">
        <location>
            <begin position="346"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="86"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="446"/>
            <end position="458"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="539"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008835.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="575" mass="61506" checksum="C357FEF6DDD2C7C7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V0S2</accession>
    <name>A0A8C5V0S2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DARS1</name>
        <name evidence="20" type="synonym">DARS</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03011268">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595548.1">
        <property type="nucleotide sequence ID" value="XM_012740094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V0S2"/>
    <dbReference type="Ensembl" id="ENSMICT00000013836.3">
        <property type="protein sequence ID" value="ENSMICP00000012622.2"/>
        <property type="gene ID" value="ENSMICG00000013832.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857626"/>
    <dbReference type="KEGG" id="mmur:105857626"/>
    <dbReference type="CTD" id="1615"/>
    <dbReference type="GeneTree" id="ENSGT01030000234618"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000144">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 20" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="196"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012622.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="RefSeq" id="XP_012595548.1"/>
        </source>
    </evidence>
    <sequence length="501" mass="57149" checksum="420EEE8418C0A30E" modified="2022-01-19" version="1">MPSANASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTAQRADEVVWIRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRTVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAIRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFCIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVVEEIADTLVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEEDLSTPNEKLLGRLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1C3</accession>
    <name>A0A8C5V1C3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein FAM234A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein ITFG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FAM234A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the FAM234 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1C3"/>
    <dbReference type="Ensembl" id="ENSMICT00000010402.3">
        <property type="protein sequence ID" value="ENSMICP00000009473.3"/>
        <property type="gene ID" value="ENSMICG00000010403.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063694"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002632">
        <property type="entry name" value="Protein FAM234A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055409">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045232">
        <property type="entry name" value="FAM234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21419:SF7">
        <property type="entry name" value="PROTEIN FAM234A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23727">
        <property type="entry name" value="Beta-prop_FAM234A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="FAM234A/B beta-propeller" evidence="11">
        <location>
            <begin position="82"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009473.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="552" mass="60178" checksum="23FF3E8A9180DD7F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1U2</accession>
    <name>A0A8C5V1U2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cullin-4B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CUL4A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15 16">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018055">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018057">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018058">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1U2"/>
    <dbReference type="Ensembl" id="ENSMICT00000012695.3">
        <property type="protein sequence ID" value="ENSMICP00000011563.3"/>
        <property type="gene ID" value="ENSMICG00000012670.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156905"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031465">
        <property type="term" value="C:Cul4B-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000003">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000001">
        <property type="entry name" value="Cullin 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000050">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000004">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000008">
        <property type="entry name" value="Cullin 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000059">
        <property type="entry name" value="Cullin-4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="17">
        <location>
            <begin position="309"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011563.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="664" mass="77417" checksum="CB09EF8233488EE5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V362</accession>
    <name>A0A8C5V362_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein AMBP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">AMBP</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="30">I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of ITIH3/HC3 and bikunin. Interacts with TNFAIP6 (via Link domain).</text>
    </comment>
    <comment type="subunit">
        <text evidence="29">Monomer. Also occurs as a complex with tryptase in mast cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="31">Monomer. Homodimer. In plasma, it occurs as a monomer or dimer and in covalently-linked complexes with immunoglobulin A (IgA), ALB/albumin and F2/prothrombin. Chromophore-bound alpha-1-microglobulin interacts with the constant region of immunoglobulin A. Chromophore-bound alpha-1-microglobulin interacts with ALB with molar ratio 2:1 and 1:1; this interaction does not prevent fatty acid binding to ALB. Interacts with F2/prothrombin (via N-terminus) with molar ratio 2:1 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin. Interacts with NDUFAB1, a subunit of mitochondrial complex I. Interacts with FN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V362"/>
    <dbReference type="Ensembl" id="ENSMICT00000015174.3">
        <property type="protein sequence ID" value="ENSMICP00000013841.1"/>
        <property type="gene ID" value="ENSMICG00000015178.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160109"/>
    <dbReference type="OMA" id="CPWLKRI"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019862">
        <property type="term" value="F:IgA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22596">
        <property type="entry name" value="Kunitz_bikunin_1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22597">
        <property type="entry name" value="Kunitz_bikunin_2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19418">
        <property type="entry name" value="lipocalin_A1M-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000007">
        <property type="entry name" value="Alpha-1-microglobulin/bikunin precursor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.10:FF:000010">
        <property type="entry name" value="Alpha1-microglobulin/bikunin (AMBP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="entry name" value="Pancreatic trypsin inhibitor Kunitz domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002968">
        <property type="entry name" value="A1-microglobln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029856">
        <property type="entry name" value="AMBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000566">
        <property type="entry name" value="Lipocln_cytosolic_FA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020901">
        <property type="entry name" value="Prtase_inh_Kunz-CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46676">
        <property type="entry name" value="PROTEIN AMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46676:SF1">
        <property type="entry name" value="PROTEIN AMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00061">
        <property type="entry name" value="Lipocalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01215">
        <property type="entry name" value="A1MCGLOBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00759">
        <property type="entry name" value="BASICPTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00179">
        <property type="entry name" value="LIPOCALIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="BPTI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00280">
        <property type="entry name" value="BPTI_KUNITZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="26" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="24" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="20" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="19" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="15 33" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034564917" description="Protein AMBP" evidence="33">
        <location>
            <begin position="20"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="34">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="34">
        <location>
            <begin position="286"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="32">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00029383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00029474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00046983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00047015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="351" mass="38775" checksum="62A7504FCF5AD676" modified="2022-01-19" version="1">MQSPRALLLLLAACLAVSADPVLPPDDIQVQENFNVSRIYGKWYNLAIGSTCPWLKKIKDRLAVSTLVLAEGATEAEVSMTSTQWRKGVCEEISGAYEKTSTEGKFLYHKPKWSVTMESYVVHTNYDEYAIFLTKKFSGRHGPSITAKLYGREPQLRDSLLQDFREVARGVGIADDSIFILADRGECVPGEQEPEPTRPPRARRAVLPQEDEGSGDGQQLLNVVKKEDACQMGYSAGPCMGMTNRYFYNGTSMACEIFQYGGCMGNANNFATEKECLQTCRTIAACNLPIVSGSCRAFNKLWAFDAAQGKCVQFVYGGCHGNGNKFYSEKECREYCGVPGDGDEELLRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V475</accession>
    <name>A0A8C5V475_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Contactin-5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CNTN5</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. Contactin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006742">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V475"/>
    <dbReference type="Ensembl" id="ENSMICT00000015973.3">
        <property type="protein sequence ID" value="ENSMICP00000014562.2"/>
        <property type="gene ID" value="ENSMICG00000015969.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158183"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000035">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000047">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000052">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000054">
        <property type="entry name" value="Contactin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000028">
        <property type="entry name" value="Neuronal cell adhesion molecule"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170:SF17">
        <property type="entry name" value="CONTACTIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44170">
        <property type="entry name" value="PROTEIN SIDEKICK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="111"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="213"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="316"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="418"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="16">
        <location>
            <begin position="517"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014562.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="640" mass="69903" checksum="2E6791AEB94AE4A8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7K8</accession>
    <name>A0A8C5V7K8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 13">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="10 13">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TRMT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="10 13"/>
    <dbReference type="EMBL" id="ABDC03027782">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645864.1">
        <property type="nucleotide sequence ID" value="XM_012790410.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645865.1">
        <property type="nucleotide sequence ID" value="XM_012790411.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645871.1">
        <property type="nucleotide sequence ID" value="XM_012790417.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7K8"/>
    <dbReference type="Ensembl" id="ENSMICT00000000799.3">
        <property type="protein sequence ID" value="ENSMICP00000000718.3"/>
        <property type="gene ID" value="ENSMICG00000000793.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000042732.2">
        <property type="protein sequence ID" value="ENSMICP00000017289.1"/>
        <property type="gene ID" value="ENSMICG00000000793.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885489"/>
    <dbReference type="CTD" id="55621"/>
    <dbReference type="GeneTree" id="ENSGT00530000063646"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 13" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="602"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="615"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="662" mass="72252" checksum="34F55D1978EA929F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V8D6</accession>
    <name>A0A8C5V8D6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin-fold anticodon binding domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FDXACB1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03006873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V8D6"/>
    <dbReference type="Ensembl" id="ENSMICT00000015786.3">
        <property type="protein sequence ID" value="ENSMICP00000014384.3"/>
        <property type="gene ID" value="ENSMICG00000045510.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160701"/>
    <dbReference type="OMA" id="IRFGVDC"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000081">
        <property type="entry name" value="Ferredoxin-fold anticodon binding domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.380:FF:000004">
        <property type="entry name" value="Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000361">
        <property type="entry name" value="Ferredoxin-fold anticodon-binding domain-containing protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="entry name" value="Ferrodoxin-fold anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="Anticodon-binding domain of PheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="531"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014384.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="624" mass="70343" checksum="B3C04C1DA9EA8177" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V8F6</accession>
    <name>A0A8C5V8F6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ras association (RalGDS/AF-6) and pleckstrin homology domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RAPH1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MRL family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V8F6"/>
    <dbReference type="Ensembl" id="ENSMICT00000052850.2">
        <property type="protein sequence ID" value="ENSMICP00000017346.1"/>
        <property type="gene ID" value="ENSMICG00000001085.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156552"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01259">
        <property type="entry name" value="PH_APBB1IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000048">
        <property type="entry name" value="Ras association (RalGDS/AF-6) and pleckstrin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000027">
        <property type="entry name" value="Ras association (RalGDS/AF-6) and pleckstrin homology domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039664">
        <property type="entry name" value="GRB/APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039665">
        <property type="entry name" value="PH_APBB1IP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243">
        <property type="entry name" value="GROWTH FACTOR RECEPTOR-BOUND PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11243:SF15">
        <property type="entry name" value="RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21989">
        <property type="entry name" value="RA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-associating" evidence="11">
        <location>
            <begin position="295"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="422"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="201"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="623" mass="70622" checksum="290271713E2BFE9C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAS3</accession>
    <name>A0A8C5VAS3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Calcium voltage-gated channel auxiliary subunit alpha2delta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">CACNA2D1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calcium channel subunit alpha-2/delta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015414">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015415">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015416">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VAS3"/>
    <dbReference type="Ensembl" id="ENSMICT00000045447.2">
        <property type="protein sequence ID" value="ENSMICP00000016599.2"/>
        <property type="gene ID" value="ENSMICG00000032377.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155209"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990454">
        <property type="term" value="C:L-type voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098992">
        <property type="term" value="C:neuronal dense core vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048787">
        <property type="term" value="C:presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086057">
        <property type="term" value="F:voltage-gated calcium channel activity involved in bundle of His cell action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086002">
        <property type="term" value="P:cardiac muscle cell action potential involved in contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904646">
        <property type="term" value="P:cellular response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902514">
        <property type="term" value="P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0086091">
        <property type="term" value="P:regulation of heart rate by cardiac conduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060307">
        <property type="term" value="P:regulation of ventricular cardiac muscle cell membrane repolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01463">
        <property type="entry name" value="vWA_VGCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000006">
        <property type="entry name" value="voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051173">
        <property type="entry name" value="Ca_channel_alpha-2/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013680">
        <property type="entry name" value="VDCC_a2/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013608">
        <property type="entry name" value="VWA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10166:SF6">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08473">
        <property type="entry name" value="VGCC_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08399">
        <property type="entry name" value="VWA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="208"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016599.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="979" mass="111562" checksum="019B51E0741761C7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBA5</accession>
    <name>A0A8C5VBA5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor Ts, mitochondrial</fullName>
            <shortName evidence="6">EF-Ts</shortName>
            <shortName evidence="6">EF-TsMt</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">TSFM</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632598.1">
        <property type="nucleotide sequence ID" value="XM_012777144.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBA5"/>
    <dbReference type="Ensembl" id="ENSMICT00000033798.2">
        <property type="protein sequence ID" value="ENSMICP00000019496.1"/>
        <property type="gene ID" value="ENSMICG00000003812.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878002"/>
    <dbReference type="KEGG" id="mmur:105878002"/>
    <dbReference type="CTD" id="10102"/>
    <dbReference type="GeneTree" id="ENSGT00390000016293"/>
    <dbReference type="OrthoDB" id="277235at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070013">
        <property type="term" value="C:intracellular organelle lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14275">
        <property type="entry name" value="UBA_EF-Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000031">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.20:FF:000007">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.20:FF:000008">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="entry name" value="Elongation factor Ts, dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="ELONGATION FACTOR TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741:SF0">
        <property type="entry name" value="ELONGATION FACTOR TS, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25025">
        <property type="entry name" value="EF-Ts_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="Elongation factor Ts (EF-Ts), dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150035" description="Elongation factor Ts, mitochondrial" evidence="7">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EFTs/EF1B dimerisation" evidence="8">
        <location>
            <begin position="117"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="325" mass="35293" checksum="2280277CDA581560" modified="2022-01-19" version="1">MSLLRSLSFCLVSRTRSCLAGSLLLQSPQLWHTFHAGSWLSSSASSKELLMKLRRKTGYSFVNCKKALETCGGDLKQAEVWLHKQAQQEGWSKAAKLHGRKTKEGLIGLLQEGNVTVLVEVNCETDFVSKNLRFQQLVQQVALGTMLHCQSLKDQVSTYSKGFLNSSELSGLPAGLGREGSLKDQLALAIGKLGENLTLKRAAWVKVPSGFYVGSYVHGGMHTPSLHNLVLGKYGALVVCETSEQKANLEDLGRRLGQHVVGMAPLSVGSLDDEPGGEAETKMLSQPYLLDPSITLGQYVQPQGVSVIDFVRFECGEGEEAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VBN1</accession>
    <name>A0A8C5VBN1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">TIR domain-containing adapter molecule 1</fullName>
            <shortName evidence="15">TICAM-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TICAM1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13 15">Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Found in a multi-helicase-TICAM1 complex at least composed of DHX36, DDX1, DDX21 and TICAM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
            <location evidence="1 15">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle</location>
            <location evidence="15">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The N-terminal region is essential for activation of the IFNB promoter activity.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028053">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VBN1"/>
    <dbReference type="Ensembl" id="ENSMICT00000047796.2">
        <property type="protein sequence ID" value="ENSMICP00000019338.2"/>
        <property type="gene ID" value="ENSMICG00000033254.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162411"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097342">
        <property type="term" value="C:ripoptosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140052">
        <property type="term" value="P:cellular response to oxidised low-density lipoprotein particle stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031663">
        <property type="term" value="P:lipopolysaccharide-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002281">
        <property type="term" value="P:macrophage activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032722">
        <property type="term" value="P:positive regulation of chemokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900017">
        <property type="term" value="P:positive regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032728">
        <property type="term" value="P:positive regulation of interferon-beta production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032755">
        <property type="term" value="P:positive regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060907">
        <property type="term" value="P:positive regulation of macrophage cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002735">
        <property type="term" value="P:positive regulation of myeloid dendritic cell cytokine production"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032816">
        <property type="term" value="P:positive regulation of natural killer cell activation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045429">
        <property type="term" value="P:positive regulation of nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032760">
        <property type="term" value="P:positive regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043330">
        <property type="term" value="P:response to exogenous dsRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034138">
        <property type="term" value="P:toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035666">
        <property type="term" value="P:TRIF-dependent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.780:FF:000001">
        <property type="entry name" value="TIR domain-containing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000024">
        <property type="entry name" value="TIR domain-containing adapter molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025735">
        <property type="entry name" value="RHIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046946">
        <property type="entry name" value="TCAM1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040886">
        <property type="entry name" value="TRIF_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47230">
        <property type="entry name" value="TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47230:SF1">
        <property type="entry name" value="TIR DOMAIN-CONTAINING ADAPTER MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12721">
        <property type="entry name" value="RHIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17798">
        <property type="entry name" value="TRIF-NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6 15" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 15" id="KW-0391">Immunity</keyword>
    <keyword evidence="11 15" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="5 15" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="TIR" evidence="17">
        <location>
            <begin position="379"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="159"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="309"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="263"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019338.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="690" mass="73164" checksum="DADD31EFFEEB4C72" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCM8</accession>
    <name>A0A8C5VCM8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pyruvate kinase</fullName>
            <ecNumber evidence="17">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PKM</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03004874">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623710.1">
        <property type="nucleotide sequence ID" value="XM_012768256.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VCM8"/>
    <dbReference type="Ensembl" id="ENSMICT00000040786.2">
        <property type="protein sequence ID" value="ENSMICP00000026219.2"/>
        <property type="gene ID" value="ENSMICG00000013532.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000050102.2">
        <property type="protein sequence ID" value="ENSMICP00000019965.2"/>
        <property type="gene ID" value="ENSMICG00000013532.3"/>
    </dbReference>
    <dbReference type="CTD" id="5315"/>
    <dbReference type="GeneTree" id="ENSGT00390000008859"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000025">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000002">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000023">
        <property type="entry name" value="Pyruvate kinase PKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="18">
        <location>
            <begin position="43"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="19">
        <location>
            <begin position="410"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019965.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="531" mass="57921" checksum="8A9805950548D933" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VD26</accession>
    <name>A0A8C5VD26_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Family with sequence similarity 83 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">FAM83A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM83 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598794.1">
        <property type="nucleotide sequence ID" value="XM_012743340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VD26"/>
    <dbReference type="Ensembl" id="ENSMICT00000039806.2">
        <property type="protein sequence ID" value="ENSMICP00000019869.1"/>
        <property type="gene ID" value="ENSMICG00000010196.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859516"/>
    <dbReference type="KEGG" id="mmur:105859516"/>
    <dbReference type="CTD" id="84985"/>
    <dbReference type="GeneTree" id="ENSGT00940000160768"/>
    <dbReference type="OrthoDB" id="9905385at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036312">
        <property type="term" value="F:phosphatidylinositol 3-kinase regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007173">
        <property type="term" value="P:epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904179">
        <property type="term" value="P:positive regulation of adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050872">
        <property type="term" value="P:white fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09181">
        <property type="entry name" value="PLDc_FAM83A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000004">
        <property type="entry name" value="protein FAM83H isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050944">
        <property type="entry name" value="FAM83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012461">
        <property type="entry name" value="SACK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16181">
        <property type="entry name" value="PROTEIN FAM83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16181:SF29">
        <property type="entry name" value="PROTEIN FAM83A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07894">
        <property type="entry name" value="SACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scaffolding anchor of CK1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="319"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="434" mass="47566" checksum="0CAA8D8B0BE311EC" modified="2022-01-19" version="1">MSRPRHMGKIRKRLEDVKSQWVRPARADFSDNESARMATDALLDGGLEAYWQALSQEGEVDFLSSVEAQYIQAQAKEPPCALDPPGGAEAGPKGLDSCSLQSGTYFPVASEGSEPALLHTWASAEKPYLKEKSSATVYFQTDKHNNIRDLIRRCIARASQVLVILMDVFTDVEIFCDLLEAANKRGVFVCVLLDQGGVELFQEMCDKAQISDSHLKNISIRSVEGEVYCAKSGRKFAGQIREKFIISDWRFVLSGSYSFTWLCGHVHRNILSKFTGMAVEPFDEEFRHLYTSSKPVMGLKSPRLAAPLLPGAGRGLPSGCLSSSGSASDRTSSDPFSSPSTGSNPHNQSVSTSSGPGSPGTPNPPPPPRFQPYHGPWGALTPPAHFCPRPHDGPPAPYSNLIAYRPTRLQLEQLGLVPRLAHTWRPFLQASPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VD75</accession>
    <name>A0A8C5VD75_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Arachidonate--CoA ligase</fullName>
            <ecNumber evidence="14">6.2.1.15</ecNumber>
            <ecNumber evidence="15">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">SLC27A4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19713"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19714"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)</text>
            <dbReference type="Rhea" id="RHEA:33655"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(9Z,12Z)-octadecadienoate(out) = (9Z,12Z)-octadecadienoate(in)</text>
            <dbReference type="Rhea" id="RHEA:45264"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a fatty acid(in) = a fatty acid(out)</text>
            <dbReference type="Rhea" id="RHEA:38879"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hexadecanoate(out) = hexadecanoate(in)</text>
            <dbReference type="Rhea" id="RHEA:45256"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.15" evidence="14"/>
    <dbReference type="EC" id="6.2.1.3" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03014911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627552.1">
        <property type="nucleotide sequence ID" value="XM_012772098.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VD75"/>
    <dbReference type="Ensembl" id="ENSMICT00000017637.3">
        <property type="protein sequence ID" value="ENSMICP00000016060.2"/>
        <property type="gene ID" value="ENSMICG00000017637.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875253"/>
    <dbReference type="KEGG" id="mmur:105875253"/>
    <dbReference type="CTD" id="10999"/>
    <dbReference type="GeneTree" id="ENSGT00940000158646"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047676">
        <property type="term" value="F:arachidonate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090434">
        <property type="term" value="F:oleoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090433">
        <property type="term" value="F:palmitoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044381">
        <property type="term" value="P:glucose import in response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990379">
        <property type="term" value="P:lipid transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001579">
        <property type="term" value="P:medium-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043588">
        <property type="term" value="P:skin development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05939">
        <property type="entry name" value="hsFATP4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000008">
        <property type="entry name" value="Long-chain fatty acid transport protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006134">
        <property type="entry name" value="PRK08279.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF11">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="24">
        <location>
            <begin position="81"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="25">
        <location>
            <begin position="520"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00035938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016060.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="643" mass="72179" checksum="94072C45E1FE692D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VFG3</accession>
    <name>A0A8C5VFG3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">USP29</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03026337">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VFG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000041980.2">
        <property type="protein sequence ID" value="ENSMICP00000018658.2"/>
        <property type="gene ID" value="ENSMICG00000036798.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161929"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd13312">
        <property type="entry name" value="PH_USP37_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.180:FF:000001">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.180">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 26/29/37, pleckstrin homology-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032069">
        <property type="entry name" value="USP37-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038093">
        <property type="entry name" value="USP37-like_PH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF711">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16674">
        <property type="entry name" value="UCH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="280"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="654"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="605"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018658.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="903" mass="101529" checksum="900BD21A7D147C6C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VI99</accession>
    <name>A0A8C5VI99_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S15a</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105883773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034314">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642659.1">
        <property type="nucleotide sequence ID" value="XM_012787205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VI99"/>
    <dbReference type="Ensembl" id="ENSMICT00000029636.2">
        <property type="protein sequence ID" value="ENSMICP00000023480.2"/>
        <property type="gene ID" value="ENSMICG00000042414.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105883773"/>
    <dbReference type="KEGG" id="mmur:105883773"/>
    <dbReference type="GeneTree" id="ENSGT00950000183198"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_A">
        <property type="entry name" value="Ribosomal_uS8_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023480.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="130" mass="14870" checksum="D3AB6EFF6493A4D1" modified="2022-01-19" version="1">MVRMNVLADALKSINNAEKRGKRQVLIRPCSKVIVWFLTVMMKHGYIGEFEIIDDHRAGKIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLLPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJ78</accession>
    <name>A0A8C5VJ78_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">PAX6 neighbor gene protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ELP4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006256">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJ78"/>
    <dbReference type="Ensembl" id="ENSMICT00000054286.2">
        <property type="protein sequence ID" value="ENSMICP00000023483.2"/>
        <property type="gene ID" value="ENSMICG00000031183.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001443"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000623">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023483.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="425" mass="46637" checksum="BC0C1B52A39038DE" modified="2022-01-19" version="1">MAAAATCGTGAGSTASVASAASKSKVTSFQRRGPRASGTDSGGLRLVSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIISGHTLLVASAKEDPADILQELPAPLLDDNCKKELDEDVCNHKTPESNVKMKIAWRYQLLPKMEQIGPVSSSRFGHYYDISKRIPQELIEASNWHGFFLPEKRSSPLKVESCSLTHGYLKLLQFIQNIIYEEGFDGSNPQKKKKNILRIGIQNLGSPLWGDDICCTENCDNSHSLTKFLYLLRGLLRTSLSACIITMPTHLIQNKAIIARVTNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNLICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKQDLAESAKLLGPGCGMMAGGKKHLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VSK6</accession>
    <name>A0A8C5VSK6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010636">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VSK6"/>
    <dbReference type="Ensembl" id="ENSMICT00000043686.2">
        <property type="protein sequence ID" value="ENSMICP00000024503.2"/>
        <property type="gene ID" value="ENSMICG00000037782.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230346"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="26S proteasome regulatory subunit 7-like OB" evidence="8">
        <location>
            <begin position="83"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="7">
        <location>
            <begin position="226"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024503.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="40991" checksum="3E714EDEAAC63140" modified="2022-01-19" version="1">IPDYASGDQWKTKEDEKYDKPTGALNEGDSALLKTYGQSTYSRQIQQVEDDIQQLLKKIIELTGIKESDTGLAPPLLWNLATDEQTLQSEKCTKIINAHSEDPKYVINVKQFAKFVVDLSDQVEPTDIEEGMRVGMDRNIKFTVHCHLSSYLIQMEEKPDITYSDIHEVVETQLLHPERFVNLGSELPKSVLLFGPLSTDKTLCARAVANRTDACFIPVIGSELNKNPYVTFFDEIDAVGGPKFDDGAGGNNEVQRTMLELINQLDGFDPPGNIKVPMATDRPDSLDPALMRPGRLDRKIEFNVERDFRFEFGSEIRSICTEAGMFAITAWQKIATEKDPFEAVNKLIKSYTKFSATPGYMIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VUP8</accession>
    <name>A0A8C5VUP8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VUP8"/>
    <dbReference type="Ensembl" id="ENSMICT00000034682.2">
        <property type="protein sequence ID" value="ENSMICP00000030490.2"/>
        <property type="gene ID" value="ENSMICG00000031408.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153770"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000350">
        <property type="entry name" value="Immunoglobulin kappa chain variable 18-36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="1" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="3" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034296392" description="Ig-like domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030490.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="141" mass="14523" checksum="CFF40E31B1F0E546" modified="2022-01-19" version="1">MRLPAQLLGLLVLWVPGSSGDIVLTQTPASLAVSPGERATISCKASQSVHVGMFGTGSSLSWFQQKPGQAPKLLIYGASKQGSGVPARFSGSGSGTDFTLTIDPVEADDAANYYCQQGKASPPTVLWGRTETCTGSCALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VUY6</accession>
    <name>A0A8C5VUY6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UBX domain-containing protein 2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">NSFL1 cofactor p37</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">p97 cofactor p37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">UBXN2B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with VCP. Does not bind ubiquitin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NSFL1C family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012477">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012478">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VUY6"/>
    <dbReference type="Ensembl" id="ENSMICT00000046889.2">
        <property type="protein sequence ID" value="ENSMICP00000030815.1"/>
        <property type="gene ID" value="ENSMICG00000028037.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00520000055567"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904780">
        <property type="term" value="P:negative regulation of protein localization to centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046604">
        <property type="term" value="P:positive regulation of mitotic centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17161">
        <property type="entry name" value="UBX_UBXN2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000001">
        <property type="entry name" value="NSFL1 (P97) cofactor (P47)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000135">
        <property type="entry name" value="UBX domain-containing protein 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF14">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="19">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="18">
        <location>
            <begin position="246"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00040562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="325" mass="36771" checksum="9EC3B8D98FB30B9B" modified="2022-01-19" version="1">YECEELAKKLENNQNDDVSRNKLALAELYEDEVKCKSSKSDRPKAAVFKSPRTPPQRFYSSENEYSGLHIVRPSTGKIVNELFKEAREHGAVPLDEATRASGDDKSKSFTGGGYRLGNSFCKRSEYIYGENQLQDVQILLKLWSNGFSLDDGELRPYSDPTNAQFLESVKRGEIPLELQRLVHGGQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAVVLIDDSVPTTKIQIRLADGSRLIQRFNSTHRILDVRDFIVQSRPEFATLDFILVTSFPNKELTDESLTLQEADILNTVILQQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VXG1</accession>
    <name>A0A8C5VXG1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Tubulin tyrosine ligase like 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TTLL13</name>
        <name evidence="9" type="synonym">LOC105870606</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tubulin--tyrosine ligase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013865">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013866">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VXG1"/>
    <dbReference type="Ensembl" id="ENSMICT00000053390.2">
        <property type="protein sequence ID" value="ENSMICP00000032336.2"/>
        <property type="gene ID" value="ENSMICG00000012703.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161367"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070740">
        <property type="term" value="F:tubulin-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000009">
        <property type="entry name" value="tubulin polyglutamylase TTLL5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12241:SF91">
        <property type="entry name" value="TUBULIN POLYGLUTAMYLASE TTLL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032336.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="817" mass="94402" checksum="A4FAF1D1FD6D8EB9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYC2</accession>
    <name>A0A8C5VYC2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Speedy/RINGO cell cycle regulator family member C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPDYC</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Speedy/Ringo family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYC2"/>
    <dbReference type="Ensembl" id="ENSMICT00000028265.2">
        <property type="protein sequence ID" value="ENSMICP00000032902.2"/>
        <property type="gene ID" value="ENSMICG00000037151.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154524"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020984">
        <property type="entry name" value="Speedy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052316">
        <property type="entry name" value="Speedy-Ringo_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545">
        <property type="entry name" value="SEEDY PROTEIN A/C FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31545:SF2">
        <property type="entry name" value="SPEEDY PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11357">
        <property type="entry name" value="Spy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="290" mass="33073" checksum="64939B3C8B4EF6A1" modified="2022-01-19" version="1">ILWVAPELRSPCPNSTPYEMSEAQDPAYVPVVMTQLRLGGCSWQGGGNGFLHFRQHQELQAFLNLLEDSFVQDFLSTDCCFRVSDKYLLAMVLVYFQRAHLKLSEYTHSNLFLALYLANDMEEDLEEAKCEIFPWALGEDWCLQVGKFLQQRDELWARMGFRALVSRQCCEEVMAKEPSHWAWTRERRPHHGGVQRGRPARFPRGPGLSPPPCSLCDLPQQCSLHHPLPASSKCPSLTLKCHHPDSQNYLSGVKNPCGGDFLIILPPQMQLEPGTYTLHIFPKPSSHPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VYY4</accession>
    <name>A0A8C5VYY4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polo like kinase 5 (inactive)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PLK5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027997">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VYY4"/>
    <dbReference type="Ensembl" id="ENSMICT00000028073.2">
        <property type="protein sequence ID" value="ENSMICP00000033379.1"/>
        <property type="gene ID" value="ENSMICG00000034085.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162321"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000007">
        <property type="entry name" value="Polo like kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000189">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000014">
        <property type="entry name" value="Serine/threonine-protein kinase PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000959">
        <property type="entry name" value="POLO_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF43">
        <property type="entry name" value="INACTIVE SERINE_THREONINE-PROTEIN KINASE PLK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00659">
        <property type="entry name" value="POLO_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50078">
        <property type="entry name" value="POLO_BOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="10">
        <location>
            <begin position="373"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="POLO box" evidence="10">
        <location>
            <begin position="472"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="553" mass="60968" checksum="CDE92F1771837506" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZC5</accession>
    <name>A0A8C5VZC5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ATP6V0D2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629698.1">
        <property type="nucleotide sequence ID" value="XM_012774244.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VZC5"/>
    <dbReference type="Ensembl" id="ENSMICT00000039425.2">
        <property type="protein sequence ID" value="ENSMICP00000033477.1"/>
        <property type="gene ID" value="ENSMICG00000006227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876551"/>
    <dbReference type="KEGG" id="mmur:105876551"/>
    <dbReference type="CTD" id="245972"/>
    <dbReference type="GeneTree" id="ENSGT00390000002200"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1690.10:FF:000003">
        <property type="entry name" value="V-type proton ATPase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018497">
        <property type="entry name" value="V-ATP_synth_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR018497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="350" mass="40613" checksum="DA01434756AF37B2" modified="2022-01-19" version="1">MLECAELYFNVDHGYLEGLVRGCKASLLTQQDYINLAQCETLEDLKIHLQTTDYGNFLANQTNPLTVSKIDTEMRKRLCREFDYFRNNSLEPLSTFFTYMTCSYMIDNVILLMNGALQKKSVKEILVKCHPLGRFTEMEAVNIAETPSDLFNAILVETPLAPFFQDCMSENTLDELNIELLRNKLYKSYLEAFYKFCKNHGDVTAEVMCPILEFEADRRAFIITFNSFGTELSKEDRETLYPTIGKLYPEGLRLLAQAEDFDQMKRVADHYGVYKPLFEAVGGSGGKTLEDVFYEHEVQINVLAFNRQFHYGVFYAYVKLKEQEMRNIVWIAECISQRHRTKINSYIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0K2</accession>
    <name>A0A8C5W0K2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WASH complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WASHC1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WASH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634896.1">
        <property type="nucleotide sequence ID" value="XM_012779442.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634897.1">
        <property type="nucleotide sequence ID" value="XM_012779443.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634898.1">
        <property type="nucleotide sequence ID" value="XM_012779444.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W0K2"/>
    <dbReference type="Ensembl" id="ENSMICT00000032498.2">
        <property type="protein sequence ID" value="ENSMICP00000034209.1"/>
        <property type="gene ID" value="ENSMICG00000028988.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105879290"/>
    <dbReference type="CTD" id="100287171"/>
    <dbReference type="GeneTree" id="ENSGT00390000016717"/>
    <dbReference type="OrthoDB" id="9535213at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028290">
        <property type="entry name" value="WASH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021854">
        <property type="entry name" value="WASH1_WAHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331">
        <property type="entry name" value="CXYORF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23331:SF5">
        <property type="entry name" value="WAS PROTEIN FAMILY HOMOLOG 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11945">
        <property type="entry name" value="WASH_WAHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="WH2" evidence="9">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="295"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="470" mass="50483" checksum="34170D58F24D48E0" modified="2022-01-19" version="1">MTPVRTQHCLAGQTYAVPLIQPDLRREEAIQQVADALQYLQKVSADIFSRISQRVEVSRSQLQAIGERVSLAQAKIEKIKGSKKAIKVFSSAKYPAPEHLQEHSSIFTGAQDPGLQRRPRHRIQSKHRPLDGRALQEKLQYFPVCVSITPQPEDAAEEGLGALPSNISSVSSLLLFNTTENLYKKYVLLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQVPENYFYVPDLGQVPEIDVPSYLPDLPGIADDLTYSADLGPGIAPSAPGTIPELPTFHTEVAEPFKPDLENGVLSVPPPPPPPPPPPPAPAALVSAPVPQTMAPAGQGAREDDSGSSVSPSAPVLGAPKEVAEPSSGRASLLESIRQAGGIGKAKLRSVKERKLEKKKQKEQEQVRATSQGGDLMSDLFNKLAMRRKGISGKGPGSGASEGPGGAFARVSDSIPPLPPPQQPQGEEDEDDWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1L8</accession>
    <name>A0A8C5W1L8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Protein NDRG2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">NDRG2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with CTNNB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Growth cone</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Perinuclear region</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NDRG family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004419">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608113.1">
        <property type="nucleotide sequence ID" value="XM_012752659.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608114.1">
        <property type="nucleotide sequence ID" value="XM_012752660.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608115.1">
        <property type="nucleotide sequence ID" value="XM_012752661.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608116.1">
        <property type="nucleotide sequence ID" value="XM_012752662.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1L8"/>
    <dbReference type="Ensembl" id="ENSMICT00000028701.2">
        <property type="protein sequence ID" value="ENSMICP00000034790.2"/>
        <property type="gene ID" value="ENSMICG00000016864.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000046089.2">
        <property type="protein sequence ID" value="ENSMICP00000030559.1"/>
        <property type="gene ID" value="ENSMICG00000016864.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864694"/>
    <dbReference type="KEGG" id="mmur:105864694"/>
    <dbReference type="CTD" id="57447"/>
    <dbReference type="GeneTree" id="ENSGT00950000182872"/>
    <dbReference type="OMA" id="KTCFQPL"/>
    <dbReference type="OrthoDB" id="741027at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904706">
        <property type="term" value="P:negative regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090361">
        <property type="term" value="P:regulation of platelet-derived growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010574">
        <property type="term" value="P:regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990874">
        <property type="term" value="P:vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000034">
        <property type="entry name" value="NDRG2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004142">
        <property type="entry name" value="NDRG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11034">
        <property type="entry name" value="N-MYC DOWNSTREAM REGULATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03096">
        <property type="entry name" value="Ndr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8 12" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 12" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="371" mass="40774" checksum="F32A194056EF6083" modified="2022-01-19" version="1">MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAIFTYHDVGLNYKSCFQPLFQFGDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCILQYLNFSTIIGIGVGAGAYVLSRYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSVAEMILGHLFSQEELSRNSELIQKYRNIVTHAPNLENIELYWNSYNNRRDLNFERGGDITLKCPVMLVVGDQAPHEDAVVECNSKLDPTQTSFLKMADSGGQPQLTQPGKLTEAIKYFLQGMGYMASSCMTRLSRSRTASLTSAASIDGSRSRSRTLSQSSESGTLSSGPPGHTMEVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2A6</accession>
    <name>A0A8C5W2A6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2A6"/>
    <dbReference type="Ensembl" id="ENSMICT00000046867.2">
        <property type="protein sequence ID" value="ENSMICP00000031856.2"/>
        <property type="gene ID" value="ENSMICG00000030785.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011776"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019810">
        <property type="term" value="F:putrescine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031856.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="286" mass="32831" checksum="CB3C9038022E5F70" modified="2022-01-19" version="1">METAHFFQRTEKLLEVWFSQQHPDTNQGSGDLRAILRSEWDTLLKDAQCSIVSVTKPDKQEGYVLSESSTLVSKRRFILKTSLVLLLKFARDYSWFDSVQSFFYSGKNFMKPFHQRYPELSNQTANQTLEVLMSELHPAVMDQLYMKDGVTAKDVTCGSRIRDPMPGSVFDATLSNPCGYLMNKMKSDGPYWAIPITPEPEFSYVSFETNLSQTSYDDLITKVVEVFKPGKFMTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2G6</accession>
    <name>A0A8C5W2G6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-retinol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.300</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RDH13</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03026654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026655">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630990.2">
        <property type="nucleotide sequence ID" value="XM_012775536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2G6"/>
    <dbReference type="Ensembl" id="ENSMICT00000032606.2">
        <property type="protein sequence ID" value="ENSMICP00000035178.2"/>
        <property type="gene ID" value="ENSMICG00000033024.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105877189"/>
    <dbReference type="CTD" id="112724"/>
    <dbReference type="GeneTree" id="ENSGT00940000159641"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09807">
        <property type="entry name" value="retinol-DH_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000145">
        <property type="entry name" value="Retinol dehydrogenase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004846">
        <property type="entry name" value="PRK06197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF59">
        <property type="entry name" value="RETINOL DEHYDROGENASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035178.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="334" mass="36380" checksum="3FBF4F45B1A61E95" modified="2022-01-19" version="1">MSRYVLPVSALGTVVGGAVLLKDYVAGGACPSKATIHGKTVIVTGANTGIGKQTALELAKRGGNIILACRDMEKCEAAAKDIRRETLNHHVNARHLDLASLKSIREFAAKIIAEEERVDILVNNAAVMRCPHWTTEDGFEMQFGVNHLGHFLLTNLLLDKLKASAPSRVINVTSLAHVAGHIDFDDLNWRERKYNTKAAYCQSKLAVVLFTRELSRRLQGSGVTVNALHPGVARTELGRHTGMHNSTFSSFTLGPIFWLLVKSPQLAAQPSTYLAVAEELEGVSGKYFDGLKEKAPAPEAEDDEVARRLWAESARLVGLEVSHESSARAQSLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2V5</accession>
    <name>A0A8C5W2V5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC105861765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calponin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W2V5"/>
    <dbReference type="Ensembl" id="ENSMICT00000046395.2">
        <property type="protein sequence ID" value="ENSMICP00000035748.1"/>
        <property type="gene ID" value="ENSMICG00000029851.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158886"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050606">
        <property type="entry name" value="Calponin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000557">
        <property type="entry name" value="Calponin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003096">
        <property type="entry name" value="SM22_calponin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385">
        <property type="entry name" value="CALPONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47385:SF20">
        <property type="entry name" value="TRANSGELIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00402">
        <property type="entry name" value="Calponin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00888">
        <property type="entry name" value="SM22CALPONIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00890">
        <property type="entry name" value="TRANSGELIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51122">
        <property type="entry name" value="CALPONIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="33"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="23214" checksum="E8D2EBDDA0670293" modified="2022-01-19" version="1">SPQLLLPFVMANRGPVYGLSQKVQQKIWKQHDADLEQILIQWITAQCPKDVVWPQHGCQNFQNWLKDGMVLCELINGLYPKGQAPVKKTQAFKQMEQISQFLQAAEHHGISNTDIFQTVDFWEGKNMACVQRTLMNLGGLVVARDDGLFFGDANWFPKKSKENPRNFSDNYLQEDKNVIGLQMGTNHWASQVGMTGYGMPCQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W3C8</accession>
    <name>A0A8C5W3C8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">tRNA (guanine(6)-N(2))-methyltransferase THUMP3</fullName>
            <ecNumber evidence="13">2.1.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">THUMP domain-containing protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">THUMPD3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs. This is one of the major tRNA (guanine-N(2))-methyltransferases. Also catalyzes the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 7 of tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>guanosine(7) in tRNA + S-adenosyl-L-methionine = N(2)-methylguanosine(7) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83419"/>
            <dbReference type="Rhea" id="RHEA-COMP:20126"/>
            <dbReference type="Rhea" id="RHEA-COMP:20127"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:83420"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Part of the heterodimeric THUMPD3-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit THUMPD3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.256" evidence="13"/>
    <dbReference type="EMBL" id="ABDC03028951">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W3C8"/>
    <dbReference type="Ensembl" id="ENSMICT00000045977.2">
        <property type="protein sequence ID" value="ENSMICP00000035692.2"/>
        <property type="gene ID" value="ENSMICG00000010095.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063557"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160117">
        <property type="term" value="F:tRNA (guanine(6)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160118">
        <property type="term" value="F:tRNA (guanine(7)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000073">
        <property type="entry name" value="THUMP domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.30:FF:000004">
        <property type="entry name" value="THUMP domain-containing protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.30:FF:000007">
        <property type="entry name" value="THUMP domain-containing protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053943">
        <property type="entry name" value="RlmKL-like_Mtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF13">
        <property type="entry name" value="TRNA (GUANINE(6)-N2)-METHYLTRANSFERASE THUMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="19">
        <location>
            <begin position="169"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035692.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="531" mass="59623" checksum="5219D2FFE15D9CA2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W5U8</accession>
    <name>A0A8C5W5U8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DHX33</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAH box protein 33</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">DHX33</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing. Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Inflammasome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03020480">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634806.1">
        <property type="nucleotide sequence ID" value="XM_012779352.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5U8"/>
    <dbReference type="Ensembl" id="ENSMICT00000044170.2">
        <property type="protein sequence ID" value="ENSMICP00000034432.2"/>
        <property type="gene ID" value="ENSMICG00000012715.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879249"/>
    <dbReference type="KEGG" id="mmur:105879249"/>
    <dbReference type="CTD" id="56919"/>
    <dbReference type="GeneTree" id="ENSGT00940000156747"/>
    <dbReference type="OMA" id="CHENFLH"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072559">
        <property type="term" value="C:NLRP3 inflammasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900227">
        <property type="term" value="P:positive regulation of NLRP3 inflammasome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17978">
        <property type="entry name" value="DEXHc_DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000037">
        <property type="entry name" value="ATP-dependent RNA helicase DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000750">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1271">Inflammasome</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="84"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="277"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023233"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00056853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00071560"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083359"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034432.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="707" mass="78970" checksum="36B57E7D4076E80C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W660</accession>
    <name>A0A8C5W660_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase G subunit family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000037329.1"/>
        <property type="gene ID" value="ENSMICG00000041563.1"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
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        <property type="term" value="C:synaptic vesicle membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF12">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="23"/>
            <end position="53"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="118" mass="13644" checksum="33FBCE34D12F1ECD" modified="2022-01-19" version="1">MASQSQGIQQLLRAENWAAEKVSEASKRKNWRLKQAKEEAQAEIEQYGLQREKEFKAKEAAALGSHGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W9I6</accession>
    <name>A0A8C5W9I6_MICMU</name>
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        <submittedName>
            <fullName evidence="4">Retrotransposon Gag like 6</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="primary">RTL6</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03008990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W9I6"/>
    <dbReference type="Ensembl" id="ENSMICT00000049487.2">
        <property type="protein sequence ID" value="ENSMICP00000036222.1"/>
        <property type="gene ID" value="ENSMICG00000031689.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105867485"/>
    <dbReference type="KEGG" id="mmur:105867485"/>
    <dbReference type="CTD" id="84247"/>
    <dbReference type="GeneTree" id="ENSGT00940000162853"/>
    <dbReference type="OrthoDB" id="9660564at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="DUF4939"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16297">
        <property type="entry name" value="DUF4939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4939" evidence="3">
        <location>
            <begin position="96"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
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            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
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        <location>
            <begin position="29"/>
            <end position="63"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <end position="94"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="239" mass="25985" checksum="46DC6B2F91DC5057" modified="2022-01-19" version="1">MVQPQTAKAESPASAAASSAQMDDVIDTLTSLRLTNSALRREASTLRAEKANLTNMLESVMAELTLLRTRARIPGALQITPPISAITSNGTRPMTTPPTSLPEPFSGDPGQLAGFLMQMDRFMIFQASRFPGEAERVAFLVSRLTGEAEKWAIPHMQPDSPLRNNYQGFLAELRRTYKSPLRHARRAQIRKTSASNRAVRERQTLCRQLAAAGTGPCPVHPASNGSSPAPALPTRARNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAK4</accession>
    <name>A0A8C5WAK4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arginine/serine-rich protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RSRP1</name>
        <name evidence="8" type="synonym">LOC105863565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probably acts as a spliceosomal factor that contributes to spliceosome assembly and regulates the isoform switching of proteins such as PARP6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RSRP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WAK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000037684.2">
        <property type="protein sequence ID" value="ENSMICP00000035869.2"/>
        <property type="gene ID" value="ENSMICG00000016214.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111390"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029656">
        <property type="entry name" value="RSRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47622">
        <property type="entry name" value="ARGININE/SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47622:SF1">
        <property type="entry name" value="ARGININE_SERINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17069">
        <property type="entry name" value="RSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034666"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035869.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="289" mass="33310" checksum="E449FD61A2936E1D" modified="2022-01-19" version="1">MSNYVNDMWPGSPQHSPSMCGSGDSSRLSSRSRSRSSGSSRPYSRVSSRSSSRSRNRPRRRSRSRSRSQRRHQRKYRRYSRSYSRSRSRSRSRRYRERRYGPSRRYYRSPSRCRSRSRSRSRGRSYYRSSCALTRGRRYYGFGRTVSPEEYRWKERSRTRSRSRTPFRLSEKDRMELLEIAKANAAKALGTTNIDLPPSLRTVAVTKERNRGTAVPNSGAKLELSEELTEDGTKNSSGKSSQQRSIAFSSNNSVAKPIQKSAKAAAEETTLGSPKITQKKSPYGLWRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XC43</accession>
    <name>A0A8C5XC43_MICMU</name>
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        <submittedName>
            <fullName evidence="5">Supervillin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SVIL</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the villin/gelsolin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028319">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000005410.3">
        <property type="protein sequence ID" value="ENSMICP00000004932.3"/>
        <property type="gene ID" value="ENSMICG00000005393.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154653"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043034">
        <property type="term" value="C:costamere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007519">
        <property type="term" value="P:skeletal muscle tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="gelsolin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11289">
        <property type="entry name" value="gelsolin_S2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11293">
        <property type="entry name" value="gelsolin_S4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11288">
        <property type="entry name" value="gelsolin_S5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Supervillin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="supervillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000015">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000016">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000022">
        <property type="entry name" value="supervillin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.950.10">
        <property type="entry name" value="Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036886">
        <property type="entry name" value="Villin_headpiece_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF45">
        <property type="entry name" value="SUPERVILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47050">
        <property type="entry name" value="VHP, Villin headpiece domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="4">
        <location>
            <begin position="1399"/>
            <end position="1446"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        </location>
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    </feature>
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            <begin position="2246"/>
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    </feature>
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        </location>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004932.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2268" mass="251023" checksum="8CB86803E21EA629" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XCR8</accession>
    <name>A0A8C5XCR8_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Tetratricopeptide repeat domain 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TTC24</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003180">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XCR8"/>
    <dbReference type="Ensembl" id="ENSMICT00000008292.3">
        <property type="protein sequence ID" value="ENSMICP00000007553.3"/>
        <property type="gene ID" value="ENSMICG00000008294.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111346"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024812">
        <property type="entry name" value="TPR_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47050:SF2">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13176">
        <property type="entry name" value="TPR_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="354"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007553.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="583" mass="63356" checksum="5BE16D40012E44F3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJL6</accession>
    <name>A0A8C5XJL6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ANAPC5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the APC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637754.2">
        <property type="nucleotide sequence ID" value="XM_012782300.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJL6"/>
    <dbReference type="Ensembl" id="ENSMICT00000052634.2">
        <property type="protein sequence ID" value="ENSMICP00000029045.2"/>
        <property type="gene ID" value="ENSMICG00000002234.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880913"/>
    <dbReference type="CTD" id="51433"/>
    <dbReference type="GeneTree" id="ENSGT00390000018674"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141198">
        <property type="term" value="P:protein branched polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16270">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000127">
        <property type="entry name" value="anaphase-promoting complex subunit 5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048968">
        <property type="entry name" value="Apc5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21371">
        <property type="entry name" value="Apc5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5 N-terminal" evidence="21">
        <location>
            <begin position="30"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="20">
        <location>
            <begin position="254"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="20">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029045.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="755" mass="85173" checksum="D56A22569081BF5E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XKR7</accession>
    <name>A0A8C5XKR7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">26S proteasome AAA-ATPase subunit RPT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Proteasome 26S subunit ATPase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PSMC2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC2 and few additional components. Interacts with NDC80/HEC; this interaction is detected only during M phase. Interacts and SQSTM1. Interacts with PAAF1. Directly interacts with TRIM5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015387">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602573.1">
        <property type="nucleotide sequence ID" value="XM_012747119.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XKR7"/>
    <dbReference type="SMR" id="A0A8C5XKR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000046024.2">
        <property type="protein sequence ID" value="ENSMICP00000032771.1"/>
        <property type="gene ID" value="ENSMICG00000008379.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861556"/>
    <dbReference type="KEGG" id="mmur:105861556"/>
    <dbReference type="CTD" id="5701"/>
    <dbReference type="GeneTree" id="ENSGT01020000230346"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="208"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="38"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="433" mass="48648" checksum="302E4FA62A48104C" modified="2022-01-19" version="1">MPDYLGADQRKTKEEEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XLP5</accession>
    <name>A0A8C5XLP5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HERPUD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Could be involved in the unfolded protein response (UPR) pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015725">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633013.1">
        <property type="nucleotide sequence ID" value="XM_012777559.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XLP5"/>
    <dbReference type="Ensembl" id="ENSMICT00000032857.2">
        <property type="protein sequence ID" value="ENSMICP00000035515.1"/>
        <property type="gene ID" value="ENSMICG00000036369.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878233"/>
    <dbReference type="KEGG" id="mmur:105878233"/>
    <dbReference type="CTD" id="64224"/>
    <dbReference type="GeneTree" id="ENSGT00390000017671"/>
    <dbReference type="OrthoDB" id="21589at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17119">
        <property type="entry name" value="Ubl_HERP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000046">
        <property type="entry name" value="Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039751">
        <property type="entry name" value="HERPUD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943:SF5">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12943">
        <property type="entry name" value="HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0834">Unfolded protein response</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="405" mass="45087" checksum="E81D67FDC0CDD638" modified="2022-01-19" version="1">MDQSGMEIPVTLIIKAPNQKYSDQTISCFLNWTVGKLKMHLSNVYPSKPLTKDQRLVYSGRLLPDHLQLKDILRKQDEYHMVHLVCTSRTPPGSPKSSTNRESREALASSSNSSSDHSGSTTPSSSQETLSLAASSSSEGLRQRTPSQAQTNPAQSHQFPYVMQGNVDNQFPEQAIPPGFPAYPAFSPLQMLWWQQMYAQQYYMQYQAAVSAQATSNANSAQPTASQPLNLAHVPGEEPPPAPNLVAQENRPMNENVQMNAQGGPVLNDEDFNRDWLDWMYTFSRAAILLSIVYFYSSFSRFIMVMGAMLLVYLHQAGWFPFRQEGGQQQAPNNARVNNDGQNAHNLELEEMEHLMDDGLEDESGEDTSEDASAIQRPGLMASAWSFITTFFTSLIPEGPPQVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNH5</accession>
    <name>A0A8C5XNH5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Epsin 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EPN2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603328.1">
        <property type="nucleotide sequence ID" value="XM_012747874.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000054925.2">
        <property type="protein sequence ID" value="ENSMICP00000038353.1"/>
        <property type="gene ID" value="ENSMICG00000005739.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861951"/>
    <dbReference type="CTD" id="22905"/>
    <dbReference type="GeneTree" id="ENSGT00940000157239"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16990">
        <property type="entry name" value="ENTH_Epsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000002">
        <property type="entry name" value="epsin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF50">
        <property type="entry name" value="EPSIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="12"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="584" mass="62135" checksum="261FCAEF0D37E45C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XP27</accession>
    <name>A0A8C5XP27_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03035804">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XP27"/>
    <dbReference type="Ensembl" id="ENSMICT00000014227.3">
        <property type="protein sequence ID" value="ENSMICP00000038478.1"/>
        <property type="gene ID" value="ENSMICG00000014241.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012840"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22761">
        <property type="entry name" value="OTU_OTUD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000003">
        <property type="entry name" value="OTU domain-containing protein 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049772">
        <property type="entry name" value="OTU_OTUD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF21">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="164"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="295" mass="33625" checksum="75B653F22812FF50" modified="2022-01-19" version="1">WKVPASQWCKFLPARALGYLVDMEADLTEELEEKEQLVRRHSKEKKELQAKIQGMKNAVPKNDKKRRKQLTEDAAKLEKEMEQKHGEELEQLKLTSKENKIDCVAVNISNLVLEIQPPQISKVGKAALENEQEERIAEAEIENLSGARHVESEKLAQILAARQLEIKQIPSDGHCMYRAIENQLKEQDDTLTVVALKCQTAGYMQSHVEDFLPFLTNPNTEDMYTPEEFGKYCDDIVNTAAWGGQLELRTLSHILQTPIEIIQADSPPIVVDEEYPKKPLILVYMTHAYATENCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XPB2</accession>
    <name>A0A8C5XPB2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytochrome P450</fullName>
            <ecNumber evidence="15">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CYP2A13P</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cytochromes P450 are a group of heme-thiolate monooxygenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17149"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:142491"/>
            <dbReference type="EC" id="1.14.14.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03026933">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XPB2"/>
    <dbReference type="Ensembl" id="ENSMICT00000038444.2">
        <property type="protein sequence ID" value="ENSMICP00000038756.2"/>
        <property type="gene ID" value="ENSMICG00000017011.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154117"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008392">
        <property type="term" value="F:arachidonate epoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009804">
        <property type="term" value="P:coumarin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019373">
        <property type="term" value="P:epoxygenase P450 pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000238">
        <property type="entry name" value="Cytochrome P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008067">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF180">
        <property type="entry name" value="CYTOCHROME P450 2A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01684">
        <property type="entry name" value="EP450ICYP2A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034341675" description="Cytochrome P450" evidence="16">
        <location>
            <begin position="20"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU368053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038756.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="469" mass="53575" checksum="D981FDCF66F0C5CE" modified="2022-01-19" version="1">MLASGLLLVALLACLTVMALLSVWRQRKIWGKLPPGPTPLPFLGNYLQLNTEQMYNSLMKISERYGPVFTVHLGPRRVVVLCGYDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSITTLRDFGVGKRGIEERIQEEAGFLIEAFRATRGALVDPTFFLSQAFCNVISTVAFGDRFHYENKELLSLLGMMKGSLEFTATSAGQLYEMFYSAFKELQGLEDFIAKKEVQPSSHCLPLQEKKNPNTEFYMKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMIPMGLARRVTKDTKFRDFFLPKGTEVFPMLGSVLRDPKFFSNPRDFNPQHFLDEKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFLTTILQNFRFQSPQSPEDIDVSPKHVGFATIPRNYTMSFLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XR58</accession>
    <name>A0A8C5XR58_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit E-interacting protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">EIF3L</name>
        <name evidence="4" type="synonym">EIF3EIP</name>
        <name evidence="4" type="synonym">EIF3S6IP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RRN3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008876">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008877">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008879">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XR58"/>
    <dbReference type="Ensembl" id="ENSMICT00000049381.2">
        <property type="protein sequence ID" value="ENSMICP00000039842.2"/>
        <property type="gene ID" value="ENSMICG00000013090.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000411"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034562202" description="Eukaryotic translation initiation factor 3 subunit L" evidence="5">
        <location>
            <begin position="19"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="351"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039842.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="584" mass="68608" checksum="5ABA35A58E7F24B2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTU7</accession>
    <name>A0A8C5XTU7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain and KOW motifs-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GPKOW</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding protein involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MOS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTU7"/>
    <dbReference type="Ensembl" id="ENSMICT00000070855.1">
        <property type="protein sequence ID" value="ENSMICP00000041349.1"/>
        <property type="gene ID" value="ENSMICG00000045083.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015154"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13152">
        <property type="entry name" value="KOW_GPKOW_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13153">
        <property type="entry name" value="KOW_GPKOW_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041993">
        <property type="entry name" value="GPKOW_KOW1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041994">
        <property type="entry name" value="GPKOW_KOW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25088">
        <property type="entry name" value="GPKOW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="476" mass="52259" checksum="4071EBCF2D371EEF" modified="2022-01-19" version="1">MADAEDRVLQLAATSTAPISFGFTRKSARRRLADPGDGAGPAPEEKDFLKTVERRELQSVKPSEAPKELIIPLIQNGHRRQPLAQPPGPSMDTGALVDGVLSQAVKEIIEESKKSLEERENAGIDPTLAIPMIQKGCTPNREGADSEPQAETMPEEADYESVPVEAYGMAMLRGMGWKPGKGIGRTFNQVVKPRVNSLRPKGLGLGANLTEAQALTPTSSSHVPRPDKEQEKDKEDQPEALVPGGAVVVLSGPHRGLYGKVEGLDPDNVRAMVRLAAGSRMVTVSEYCLRSVSQQEFDKNSLDLRQQNGTASSRKALRDQDLHVQQENSERKRKHLPNRQDGPAAKSGKAAPRSQHWLHRDLRVRFVNKLHKGGQYYNTKMTIEDVLSPDTCVCRTDEGRVLEGLKEDMLETLVPKAEGDCVMVVLGPHAGRVGHLLGRDIARSRALVQLRRENQVVELHYDAVCQYVGPSDTDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVV0</accession>
    <name>A0A8C5XVV0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KRAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC105864196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017177">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XVV0"/>
    <dbReference type="Ensembl" id="ENSMICT00000070357.1">
        <property type="protein sequence ID" value="ENSMICP00000041749.1"/>
        <property type="gene ID" value="ENSMICG00000043348.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000164574"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
    </dbReference>
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        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF158">
        <property type="entry name" value="KRAB DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="118" mass="13841" checksum="8A9DA4353199DEFB" modified="2022-01-19" version="1">GLLTFKDVAIEFSWEEWACLDPAQQNLYRDVMLENYRNLVSLGLVVSKPDLITFLEQRREPWNVKSHEIVAKHQGIFSLYTQGLWKKQCLEAPFQTMTLEVFGICGLENIYLKKDWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XWL0</accession>
    <name>A0A8C5XWL0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">G protein-coupled receptor 142</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GPR142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XWL0"/>
    <dbReference type="Ensembl" id="ENSMICT00000058311.1">
        <property type="protein sequence ID" value="ENSMICP00000042187.1"/>
        <property type="gene ID" value="ENSMICG00000035066.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105878900"/>
    <dbReference type="GeneTree" id="ENSGT00940000160948"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000126">
        <property type="entry name" value="Probable G-protein coupled receptor 139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052477">
        <property type="entry name" value="Orphan_GPCR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 142-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46272">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="62"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="351" mass="38210" checksum="A25FDF866D42D454" modified="2022-01-19" version="1">MGLEGRDTAGQPQTALPPTPNGSGPSPESGDRWLEIPEPSPCVAGVIPVIYYSVLLGLGLPVNLLTAAALARLAARTRKPSYCYLLALTASDIVTQVVIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLLTADRYSALCRPLRHRAASSPGRTRRAIAAVLGAALLTGIPFYWWLDVWRDADPPSTLDKVLKWAHCLIVYFIPCGVFLVTNSAIVRRLRKRGRRGPHPRVGKSTAILLGVTTLFALLWAPRIFVMLFHMYVAPVHRDWRVHLALDVANMAAMLNTVVNFCLYCFVSKTFRATARQVIHDAHLPCVPGSRPEGMVAEPAQKPLGVPKGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXM7</accession>
    <name>A0A8C5XXM7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Potassium channel tetramerization domain containing 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">KCTD14</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03006569">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006570">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599984.1">
        <property type="nucleotide sequence ID" value="XM_012744530.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXM7"/>
    <dbReference type="Ensembl" id="ENSMICT00000062837.1">
        <property type="protein sequence ID" value="ENSMICP00000043042.1"/>
        <property type="gene ID" value="ENSMICG00000044183.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105860081"/>
    <dbReference type="KEGG" id="mmur:105860081"/>
    <dbReference type="CTD" id="65987"/>
    <dbReference type="GeneTree" id="ENSGT00940000160762"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18371">
        <property type="entry name" value="BTB_POZ_KCTD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057890">
        <property type="entry name" value="KCTD7/14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499:SF3">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14499">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25611">
        <property type="entry name" value="KCTD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="20"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="240" mass="27332" checksum="53903E329C32162A" modified="2022-01-19" version="1">MISPTSVPRSPRPGPPTISTVVELNVGGEFYTTTLGTLRKLPGSKLAEMFSSSAKACTDAEGRFFIDRPGTYFRPILDYLRSGQVPRQHIPEVYREAQFYEIKPLVKLLEDTPQIFGEQMARKQFLLRVPGYSENLELMVRLARAEAVAARRSSVLVCAVHTEEEDAQSAEALRALEADKKSVVKFGPWKAAPDTDDLLHCVEMDIKAQGYTVFYERYQFEKVFRARPCLSFYTFVFTWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y265</accession>
    <name>A0A8C5Y265_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAGE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036559">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y265"/>
    <dbReference type="Ensembl" id="ENSMICT00000058434.1">
        <property type="protein sequence ID" value="ENSMICP00000045132.1"/>
        <property type="gene ID" value="ENSMICG00000044560.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153097"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031320">
        <property type="entry name" value="GAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008625">
        <property type="entry name" value="GAGE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14047">
        <property type="entry name" value="P ANTIGEN FAMILY MEMBER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14047:SF33">
        <property type="entry name" value="X ANTIGEN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05831">
        <property type="entry name" value="GAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01379">
        <property type="entry name" value="GAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAGE" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="63" mass="6973" checksum="2E1A2EAE88EF1941" modified="2022-01-19" version="1">MSHRGRSTYRPRGRRSEEEFSQQVGPVVAQQAGDERRGQDEPPAGNQDVNPDQEINEGAPAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y277</accession>
    <name>A0A8C5Y277_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ring finger protein, transmembrane 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RNFT2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y277"/>
    <dbReference type="Ensembl" id="ENSMICT00000059742.1">
        <property type="protein sequence ID" value="ENSMICP00000045088.1"/>
        <property type="gene ID" value="ENSMICG00000010987.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158419"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904294">
        <property type="term" value="P:positive regulation of ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16742">
        <property type="entry name" value="RING-HC_RNFT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044235">
        <property type="entry name" value="RNFT1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860:SF2">
        <property type="entry name" value="RING FINGER AND TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15860">
        <property type="entry name" value="UNCHARACTERIZED RING FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="427" mass="46537" checksum="928F2BE21EE04034" modified="2022-01-19" version="1">MWLFIVNQVFRKMQRRHSSNTDNIPPERNRGQALGPEAGADEGGVFGGLKAEAAAPPALFSGLPAGLPAGAFPAGLVLGPPAAGDLFVQMPAAREDGAGRGDAAAYHHRQPHLHFPHGGAHRGSALLQHVGADPRGRDDGDEQPGTPAPALSELKAVVCWLQRGLPFILILLAKVCFQHKLGASVPGAPSEPASRSVLVILWILAFLAGNTLYVLYTFSSQQLYNSLIFLKPNLETLDFFDLLWIVGIADFVLKYITIALKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSANSYFLGGVLIVLYSLCKSFDICGRVGGVRKALKLLCTSQNYGVRATGQQCTEAGDICAICQAEFREPLILLCQHVFCEECLCLWLDRERTCPLCRSVAADTLRCWKDGATSAHFQVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y379</accession>
    <name>A0A8C5Y379_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZFP37</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624356.1">
        <property type="nucleotide sequence ID" value="XM_012768902.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y379"/>
    <dbReference type="Ensembl" id="ENSMICT00000070445.1">
        <property type="protein sequence ID" value="ENSMICP00000044582.1"/>
        <property type="gene ID" value="ENSMICG00000042832.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873713"/>
    <dbReference type="KEGG" id="mmur:105873713"/>
    <dbReference type="CTD" id="7539"/>
    <dbReference type="GeneTree" id="ENSGT00940000162711"/>
    <dbReference type="OrthoDB" id="6591996at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002295">
        <property type="entry name" value="ZFP37 zinc finger protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001938">
        <property type="entry name" value="Zinc finger protein 300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000044">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001244">
        <property type="entry name" value="Zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000200">
        <property type="entry name" value="zinc finger protein 510 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13465">
        <property type="entry name" value="zf-H2C2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="74"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="365"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="449"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="123"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="676" mass="75998" checksum="F49FB4CC6959F61D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4K4</accession>
    <name>A0A8C5Y4K4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small integral membrane protein 27</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4K4"/>
    <dbReference type="Ensembl" id="ENSMICT00000063245.1">
        <property type="protein sequence ID" value="ENSMICP00000045793.1"/>
        <property type="gene ID" value="ENSMICG00000047743.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00990000203951"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8686" checksum="5C2BC957E4EDFF24" modified="2022-01-19" version="1">LFLQRRETPKSIPNLSISTSHLDSASSWRIRSSASYLLLAIVLLSWGYVIYASTVAARRLLRKEYPDKIFGMNENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y5P8</accession>
    <name>A0A8C5Y5P8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Family with sequence similarity 187 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">FAM187B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAM187 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y5P8"/>
    <dbReference type="Ensembl" id="ENSMICT00000058224.1">
        <property type="protein sequence ID" value="ENSMICP00000046309.1"/>
        <property type="gene ID" value="ENSMICG00000044100.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063991"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039311">
        <property type="entry name" value="FAM187A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178">
        <property type="entry name" value="FAM187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32178:SF8">
        <property type="entry name" value="PROTEIN FAM187B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034734280" evidence="8">
        <location>
            <begin position="18"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="369" mass="41156" checksum="38314D23D50D3A0F" modified="2022-01-19" version="1">MLSPLLLLLGFAVPALGVYVSVSCPRGKQCQRALLSGNDVLLHCNSPGAHWHYLFAHAGDLPPFNITHLSNVETLPEGSLVIREPSPSQTGVYSCLDKNGSRVARYDVDFQDATVLHVTHRDLGQQPLENGSVHLNSKELIFTLWEPWQDCNRCGEPGERKRLGYCYVQEPLEEPTPCWLYLGEVDLWSNRMRPELQVESCHVQCQHRPSMGVGYITFDSFQLNEESESVWLSCPLGSIYRPVTWEADDTLLTWQSQLSGEALNTFLDPSTGGRQLQVFRAAIYRCFVQQEFMAQFNPKSSPEALEAQRDGSGARPQVAPEILWWKAGSVLTGLKLALLAGTLLALAGLMLRFCRPSQGAKRDCVVLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YD29</accession>
    <name>A0A8C5YD29_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TUB like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TULP2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YD29"/>
    <dbReference type="Ensembl" id="ENSMICT00000071032.1">
        <property type="protein sequence ID" value="ENSMICP00000049616.1"/>
        <property type="gene ID" value="ENSMICG00000041456.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161908"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005398">
        <property type="entry name" value="Tubby_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF24">
        <property type="entry name" value="TUBBY-RELATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16322">
        <property type="entry name" value="Tub_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Tubby C-terminal" evidence="5">
        <location>
            <begin position="258"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="506" mass="54519" checksum="384C745B261FE748" modified="2022-01-19" version="1">MVQANPDASLRLRRLWRPEKHLRNDSGFENPFLQESVPEAHLSCGACSVPRAMTCGGDGSGERGPLASPTEAGASVEEKSESQDVGDEYKVPNVGPNPGMDGDLGPNSAMNGDLGPNSAMNGDLGPNPAMDGDLGPNPAMDTDLRKNPGMDGDLGSNPGMDGDLGPNPGMDGDLGPGNLTSHQVEGGTATEDAEDLEEKKEESGSAETSSPAPADQELSKALEGRVGVGTMDVWSMSCPAPCTLGRHLGESMEAYVLRPVLPGLTLQCLISRNKHGVDKGMYPSYYLFLEAADGRKPFLLAGRKRKRSKTSNYLISMDPIDLSRNGDYFVGKLRSNVLGTKFTIFDNGVNPNKQNCFLQSPHIRQELGAVCYETNILGSRGPRKMTVIIPAVDSQNQRIICQPQNAQGSILSRFHQGAMQELILLKSKTPLWSEESGAYVLNFEGRVTRASVKNFQIVQPHNAEYLVLQFGRVAQNAFTMDFRYPLCPLQAFAICLSSLDGKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFC3</accession>
    <name>A0A8C5YFC3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELL/occludin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029532">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029533">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFC3"/>
    <dbReference type="Ensembl" id="ENSMICT00000068982.1">
        <property type="protein sequence ID" value="ENSMICP00000050588.1"/>
        <property type="gene ID" value="ENSMICG00000044657.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154828"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2670:FF:000002">
        <property type="entry name" value="RNA polymerase II elongation factor ELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031176">
        <property type="entry name" value="ELL/occludin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288">
        <property type="entry name" value="OCCLUDIN AND RNA POLYMERASE II ELONGATION FACTOR ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23288:SF8">
        <property type="entry name" value="RNA POLYMERASE II ELONGATION FACTOR ELL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144292">
        <property type="entry name" value="occludin/ELL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="317"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="571" mass="64238" checksum="107A2DB13FD89ED2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHI6</accession>
    <name>A0A8C5YHI6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHI6"/>
    <dbReference type="Ensembl" id="ENSMICT00000072393.1">
        <property type="protein sequence ID" value="ENSMICP00000051033.1"/>
        <property type="gene ID" value="ENSMICG00000048877.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008502"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="84"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="125" mass="14057" checksum="359F7999A2AFD780" modified="2022-01-19" version="1">MQGTDMATEGDVELELETETSGPERPPEKPWKHDSGAADLERVTDYAEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMTEMEISRAAAEQSLREHMGNVVEALIALTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHP1</accession>
    <name>A0A8C5YHP1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCDC50</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03000999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001000">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001001">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600645.1">
        <property type="nucleotide sequence ID" value="XM_012745191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHP1"/>
    <dbReference type="Ensembl" id="ENSMICT00000073201.1">
        <property type="protein sequence ID" value="ENSMICP00000051841.1"/>
        <property type="gene ID" value="ENSMICG00000048952.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105860444"/>
    <dbReference type="CTD" id="152137"/>
    <dbReference type="GeneTree" id="ENSGT00390000011058"/>
    <dbReference type="OrthoDB" id="9994767at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039303">
        <property type="entry name" value="CCDC50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029311">
        <property type="entry name" value="CCDC50_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115">
        <property type="entry name" value="C3ORF6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22115:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15295">
        <property type="entry name" value="CCDC50_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="5"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
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            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF15295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051841.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="482" mass="56292" checksum="B4C47F7FA856654F" modified="2022-01-19" version="1">MAEVSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNIQRNRLVQHDLRVAKKLQEEDLKAQAQLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKELQEEKKRKKHVLEFSGANVHGDNYCYEDGDQPRSRRDGELGSGFSRSYRLRSDGNTVKQRKEKLKHSLENLEELEEHCSSKRPLSSSSRDKVKGEPQLNREQYERKRSGQERLRRPPLPKISGEVFLSTDSDDWEAKSSPRTWNWEKHPQHQDQLSPNSSQKAGLHCKEAVYGRDHGPGELRKRRHRPRSPPFSESEEQLHLQNPGMKPRVVKEAISTPSRVTHRDQEWYDAEIARKLQEEELLATQVDVRAAQVAQDEEIARLLMAEEKKAYKKAKEREKSSLDKRKHDPEWKPKTPKSVHSKSKESDEPHRSKNDRPARPPPPTMTDAEDLDYTHHTNQQSSTRHFSKSESSHKGFHYKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHY3</accession>
    <name>A0A8C5YHY3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHY3"/>
    <dbReference type="Ensembl" id="ENSMICT00000073406.1">
        <property type="protein sequence ID" value="ENSMICP00000051213.1"/>
        <property type="gene ID" value="ENSMICG00000049519.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271834"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="37178" checksum="2B08E09552B2737B" modified="2022-01-19" version="1">MNGNNHSLITEFILIGFTDHPELKTLLFVVFFAIYVITMVGNLGLVVLIYAEHRLHTPMYIFLGNLALMDSCCSCAITPKMLENFYSEDRSISLYECMAQFYFLCLAETADCFLLAAMAYDRYVAICSPLQYHTKMSRKLCIQMTTGAYIAGNLHSMIHVGFLFRLTFCGSHQINHFFCDVLPLYRLSCVDPYINELMILIFAGSIQISTITIVLISYLCILFTIFTMKSKAGRGKALSTCASHFLSVSIFYGSLLFVYVQPSSVKEEDKNIPVAVFYTLVIPLLNPFIYSLRNKEVLNVMKRIMKKKSFGNFKEAKKRSFEVRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJ00</accession>
    <name>A0A8C5YJ00_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DnaJ homolog subfamily B member 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ER-associated DNAJ</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">ER-associated Hsp40 co-chaperone</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Endoplasmic reticulum DNA J domain-containing protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNAJB11</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03000974">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000976">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YJ00"/>
    <dbReference type="Ensembl" id="ENSMICT00000072980.1">
        <property type="protein sequence ID" value="ENSMICP00000051538.1"/>
        <property type="gene ID" value="ENSMICG00000049161.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000073279.1">
        <property type="protein sequence ID" value="ENSMICP00000051528.1"/>
        <property type="gene ID" value="ENSMICG00000049161.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155792"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000040">
        <property type="entry name" value="dnaJ homolog subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051736">
        <property type="entry name" value="DnaJ-B11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44298:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044681011" description="DnaJ homolog subfamily B member 11" evidence="9">
        <location>
            <begin position="23"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="25"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="358" mass="40514" checksum="7DB5DC6F728F8200" modified="2022-01-19" version="1">MAPQNLSTFCLLLLYLIGAVIAGRDFYKILGVPRSASIKDIKKAYRKLALQLHPDRNPDDPQAQEKFQDLGAAYEVLSDNEKRKQYDTYGEEGLKDGHQSSHGDIFSHFFGDFGFMFGGTPRQQDRNIPRGSDIIVDLEVTLEEVYAGNFVEVVRNKPVARQAPGKRKCNCRQEMRTTQLGPGRFQMTQEVVCDECPNVKLVNEERTLEVEIEPGVRDGMEYPFIGEGEPHVDGEPGDLRFRIKVVKHPIFERRGDDLYTNVTISLVESLVGFEMDITHLDGHKVHISRDKITRPGAKLWKKGEGLPSFDNNNIKGSLIITFDVDFPKEQLTEEAREGIKQLLKQGSVQKVYNGLQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJ76</accession>
    <name>A0A8C5YJ76_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Discoidin, CUB and LCCL domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endothelial and smooth muscle cell-derived neuropilin-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DCBLD2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YJ76"/>
    <dbReference type="Ensembl" id="ENSMICT00000073477.1">
        <property type="protein sequence ID" value="ENSMICP00000051203.1"/>
        <property type="gene ID" value="ENSMICG00000049459.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158147"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:wound healing"/>
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        <property type="entry name" value="Coagulation factor VIII"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Discoidin, CUB and LCCL domain-containing protein 2"/>
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    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="529"/>
            <end position="554"/>
        </location>
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        <location>
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        <location>
            <begin position="184"/>
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        <location>
            <begin position="294"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000048868.1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
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        </source>
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</entry>
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    <name>A0A8C6EF41_MICMU</name>
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        <recommendedName>
            <fullName evidence="11">Aryl hydrocarbon receptor repressor</fullName>
        </recommendedName>
    </protein>
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        <name evidence="15" type="primary">AHRR</name>
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    <organism evidence="15 16">
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        <name type="common">Gray mouse lemur</name>
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            <taxon>Strepsirrhini</taxon>
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        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
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                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
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                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03016284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EF41"/>
    <dbReference type="Ensembl" id="ENSMICT00000060827.1">
        <property type="protein sequence ID" value="ENSMICP00000040583.1"/>
        <property type="gene ID" value="ENSMICG00000047925.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154486"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034751">
        <property type="term" value="C:aryl hydrocarbon receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004879">
        <property type="term" value="F:nuclear receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11435">
        <property type="entry name" value="bHLH-PAS_AhRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000056">
        <property type="entry name" value="aryl hydrocarbon receptor repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000041">
        <property type="entry name" value="aryl hydrocarbon receptor repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039091">
        <property type="entry name" value="AHR/AHRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039092">
        <property type="entry name" value="AHRR_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10649:SF3">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="14">
        <location>
            <begin position="11"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="96"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="468"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="687" mass="73539" checksum="792241D79406F75B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EI83</accession>
    <name>A0A8C6EI83_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Telomeric repeat-binding factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">TERF1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03012857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012860">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144448.1">
        <property type="nucleotide sequence ID" value="XM_020288859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EI83"/>
    <dbReference type="Ensembl" id="ENSMICT00000059800.1">
        <property type="protein sequence ID" value="ENSMICP00000044340.1"/>
        <property type="gene ID" value="ENSMICG00000034600.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105883304"/>
    <dbReference type="CTD" id="7013"/>
    <dbReference type="GeneTree" id="ENSGT00940000155268"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071532">
        <property type="term" value="F:ankyrin repeat binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045141">
        <property type="term" value="P:meiotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008156">
        <property type="term" value="P:negative regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904850">
        <property type="term" value="P:negative regulation of establishment of protein localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904911">
        <property type="term" value="P:negative regulation of establishment of RNA localization to telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905839">
        <property type="term" value="P:negative regulation of telomeric D-loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904792">
        <property type="term" value="P:positive regulation of shelterin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061820">
        <property type="term" value="P:telomeric D-loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00280">
        <property type="entry name" value="TRFH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.210:FF:000001">
        <property type="entry name" value="Telomeric repeat-binding factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000129">
        <property type="entry name" value="Telomeric repeat-binding factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.210">
        <property type="entry name" value="Telomere repeat-binding factor, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036507">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017357">
        <property type="entry name" value="TERF1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038016">
        <property type="entry name" value="Telomere_bd-1_Pin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63600">
        <property type="entry name" value="Telomeric repeat binding factor (TRF) dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="16 18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 18" id="KW-0779">Telomere</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="21">
        <location>
            <begin position="371"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="20">
        <location>
            <begin position="371"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00055936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR038016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="435" mass="49828" checksum="2BEDBE8FF13796E7" modified="2022-01-19" version="1">MAEGAASGALSLRGCADGKDADPPEERMAETEGDDLEKIECQELLEFQVLLGAPEEGEEAGLMAEAEAVAAGWMLDFLCLSLCRAFRDGRSEDFHRTRDSAEAIIHGLSSLTAYQLRTVYICQFLTRIAAGKTLDAQFESDERITPLESALMIWDLIEKERDKLHEEIQNLIKIQAIAVCMENGNFKEAEEVFERIFGDPNSYTPLKRKLLMIISQKDTFHSFFQHLSFNHMMEKIKTYVNQVLNEKSSTFLMKAAAKVVESKRTRTVTSQDKPNGNDTEIETEANLYTRKSVSDKQSAVTESSEGTVSLLRSHKNLFLSKLKHGSQQQDLNKKEERVGTLQRERTIKERRASERMRKHVSKSQAVSPEKQRSRKKQAWLWEEDKNLRSGVRKYGEGNWTKILLHYKFNNRTSVMLKDRWRTMKKLKLICSDSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EFP8</accession>
    <name>A0A8B7EFP8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SH3RF3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SH3RF family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03005424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005425">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593065.1">
        <property type="nucleotide sequence ID" value="XM_012737611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EFP8"/>
    <dbReference type="Ensembl" id="ENSMICT00000010779.3">
        <property type="protein sequence ID" value="ENSMICP00000009822.3"/>
        <property type="gene ID" value="ENSMICG00000010782.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856122"/>
    <dbReference type="KEGG" id="mmur:105856122"/>
    <dbReference type="CTD" id="344558"/>
    <dbReference type="GeneTree" id="ENSGT00940000160405"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16750">
        <property type="entry name" value="RING-HC_SH3RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11931">
        <property type="entry name" value="SH3_SH3RF3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11925">
        <property type="entry name" value="SH3_SH3RF3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11785">
        <property type="entry name" value="SH3_SH3RF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000077">
        <property type="entry name" value="E3 ubiquitin-protein ligase SH3RF1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000063">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase SH3RF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000091">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase SH3RF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000001">
        <property type="entry name" value="Sorbin and SH3 domain-containing protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035816">
        <property type="entry name" value="SH3RF1/SH3RF3_SH3_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028502">
        <property type="entry name" value="SH3RF3_RING-HC_Zfn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035612">
        <property type="entry name" value="SH3RF3_SH3_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF62">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SH3RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133347" description="RING-type E3 ubiquitin transferase" evidence="16">
        <location>
            <begin position="18"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="197"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
            <begin position="259"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="17">
        <location>
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            <begin position="601"/>
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            <begin position="710"/>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EI09</accession>
    <name>A0A8B7EI09_MICMU</name>
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        <submittedName>
            <fullName evidence="13">Zinc finger CCCH-type containing 12B</fullName>
        </submittedName>
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        <name evidence="13" type="primary">ZC3H12B</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
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    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <name>Mg(2+)</name>
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        <text evidence="2">Belongs to the ZC3H12 family.</text>
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        <property type="entry name" value="RIBONUCLEASE ZC3H12B-RELATED"/>
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        <property type="entry name" value="RNase_Zc3h12a"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040979.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EM29</accession>
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            <fullName evidence="10">T-cell translocation protein 2</fullName>
        </alternativeName>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006242">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595354.1">
        <property type="nucleotide sequence ID" value="XM_012739900.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EM29"/>
    <dbReference type="Ensembl" id="ENSMICT00000033502.2">
        <property type="protein sequence ID" value="ENSMICP00000035987.2"/>
        <property type="gene ID" value="ENSMICG00000027826.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105857494"/>
    <dbReference type="CTD" id="4005"/>
    <dbReference type="GeneTree" id="ENSGT00940000160199"/>
    <dbReference type="OrthoDB" id="6352355at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043425">
        <property type="term" value="F:bHLH transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001221">
        <property type="term" value="F:transcription coregulator binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09384">
        <property type="entry name" value="LIM1_LMO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09385">
        <property type="entry name" value="LIM2_LMO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000059">
        <property type="entry name" value="LIM domain only 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000016">
        <property type="entry name" value="LIM domain only 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050945">
        <property type="entry name" value="LMO_RBTN_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787">
        <property type="entry name" value="LD11652P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45787:SF3">
        <property type="entry name" value="RHOMBOTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 12" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="14">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035987.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="221" mass="24661" checksum="4CE0F2ACB6D1F1F6" modified="2022-01-19" version="1">MEGSAVTVLERGGASSPPERRSKRRRRSGGGARAPEGVRAPAAGQPRATKGAPPPPGTPPPSPMSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7END0</accession>
    <name>A0A8B7END0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ASCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">EOLA1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03035157">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035198">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7END0"/>
    <dbReference type="Ensembl" id="ENSMICT00000044838.2">
        <property type="protein sequence ID" value="ENSMICP00000036184.1"/>
        <property type="gene ID" value="ENSMICG00000033654.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061914.1">
        <property type="protein sequence ID" value="ENSMICP00000045935.1"/>
        <property type="gene ID" value="ENSMICG00000045012.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067691.1">
        <property type="protein sequence ID" value="ENSMICP00000046358.1"/>
        <property type="gene ID" value="ENSMICG00000045012.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105857602"/>
    <dbReference type="KEGG" id="mmur:105878129"/>
    <dbReference type="CTD" id="541578"/>
    <dbReference type="GeneTree" id="ENSGT00390000012182"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007374">
        <property type="entry name" value="ASCH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033615">
        <property type="entry name" value="EOLA1/EOLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31666">
        <property type="entry name" value="PROTEIN CXORF40A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31666:SF0">
        <property type="entry name" value="PROTEIN EOLA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01022">
        <property type="entry name" value="ASCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASCH" evidence="1">
        <location>
            <begin position="18"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="170" mass="19315" checksum="B940D380F53D87A2" modified="2022-01-19" version="1">MEATRRTESSRKMKFGCLSFRQPYAGFVLNGVKTMETRWRPLLSSHRNCTVAIHIAHRDWEDDTWRELLGERLGMTPAQIQALLQEGEKFGRGVVAGLIDIGETLQCPENLTPDAVVELENQAVLTNLKQKYLTAISNPRWLLEPMPRKGGKDIFQVDIPEHLIPLGHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EPI6</accession>
    <name>A0A8B7EPI6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">palmitoyl-CoA hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ACOT6</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18262"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:30136"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>eicosanoyl-CoA + H2O = eicosanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40147"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32360"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57380"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:40148"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30139"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:25629"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:30140"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tetradecanoyl-CoA + H2O = tetradecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30807"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:40120"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.2" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03003875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EPI6"/>
    <dbReference type="Ensembl" id="ENSMICT00000037569.2">
        <property type="protein sequence ID" value="ENSMICP00000039555.2"/>
        <property type="gene ID" value="ENSMICG00000033023.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01010000222336"/>
    <dbReference type="OrthoDB" id="6347013at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2240:FF:000001">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000024">
        <property type="entry name" value="acyl-coenzyme A thioesterase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2240">
        <property type="entry name" value="Acyl-CoA thioester hydrolase/BAAT N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016662">
        <property type="entry name" value="Acyl-CoA_thioEstase_long-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014940">
        <property type="entry name" value="BAAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006862">
        <property type="entry name" value="Thio_Ohase/aa_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042490">
        <property type="entry name" value="Thio_Ohase/BAAT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824:SF17">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10824">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08840">
        <property type="entry name" value="BAAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04775">
        <property type="entry name" value="Bile_Hydr_Trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016521">
        <property type="entry name" value="Acyl-CoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase" evidence="12">
        <location>
            <begin position="59"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="BAAT/Acyl-CoA thioester hydrolase C-terminal" evidence="13">
        <location>
            <begin position="247"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016521-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039555.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="464" mass="51240" checksum="3B7ABBB3EB6878DC" modified="2022-01-19" version="1">MVASPFAVLRASRLCRGGLKSWAQLLGAPPLRLRGQITWAPVRMAATLILEPAGRCCWDEPVRIVVRGLAPEQPVTLRASLRDENGALFRAHARYRADAAGQLDLARAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDIRTPFAVELEVLDGHGPEAGRLLGRAVHERDFLPPGVRREPVRAGRVRATLFLPPGKGPFPGIIDLFGSGGGLCEYRASLLAGHGFAVLALAYFRFEDLPEYLNETHLEYFEEAVDFMLQHPKVKGPSVGLLGFSKGGDLCLSMASFLKGITATVLINACVANTIAPLHYKDMIIPNLGNDLGKLKITESGHFIFLDIWNNPVEEPNQLSLIPLEKAQGPFLFIVGMDDHNWKSEFYAHIASERLQAHGKERPQIICYPETGHCIDPPYFPLFKASMHAVVKKIVFYGGEPRAHSRAQVDAWQQIQMFFHKHLNGKKSVSHSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQK7</accession>
    <name>A0A8B7EQK7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="40">85/88 kDa calcium-independent phospholipase A2</fullName>
            <ecNumber evidence="5">3.1.1.4</ecNumber>
            <ecNumber evidence="4">3.1.1.5</ecNumber>
            <ecNumber evidence="22">3.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="43">2-lysophosphatidylcholine acylhydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="45">Group VI phospholipase A2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="44">Intracellular membrane-associated calcium-independent phospholipase A2 beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="41">Palmitoyl-CoA hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="42">Patatin-like phospholipase domain-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="49" type="primary">PLA2G6</name>
    </gene>
    <organism evidence="49 50">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="49" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="49" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="49" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:83580"/>
            <dbReference type="ChEBI" id="CHEBI:83581"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="38">
            <dbReference type="Rhea" id="RHEA:52814"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40463"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77253"/>
            <dbReference type="ChEBI" id="CHEBI:77259"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:40464"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + H2O = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:77256"/>
            <dbReference type="ChEBI" id="CHEBI:77259"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="33">
            <dbReference type="Rhea" id="RHEA:40468"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphate + H2O = 1-hexadecanoyl-sn-glycero-3-phosphate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63304"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:72859"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:63305"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41223"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:72999"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:41224"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40831"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:74344"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:40832"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:41067"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:55430"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="31">
            <dbReference type="Rhea" id="RHEA:41068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40479"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:44811"/>
            <dbReference type="ChEBI" id="CHEBI:64496"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:40480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40427"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73003"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:40428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40431"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73009"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:40432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40811"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73002"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40812"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="30">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="30">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-octadecanoyl-sn-glycero-3-phosphoethanolamine + 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63256"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:75036"/>
            <dbReference type="ChEBI" id="CHEBI:78832"/>
            <dbReference type="ChEBI" id="CHEBI:146277"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:63257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40519"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:73858"/>
            <dbReference type="ChEBI" id="CHEBI:74965"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:40520"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="39">
            <text>2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40827"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:76079"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="39">
            <dbReference type="Rhea" id="RHEA:40828"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36702"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:36232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>hexadecanoyl-CoA + H2O = hexadecanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16645"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="EC" id="3.1.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:16646"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cell projection</location>
            <location evidence="21">Pseudopodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="5"/>
    <dbReference type="EC" id="3.1.1.5" evidence="4"/>
    <dbReference type="EC" id="3.1.2.2" evidence="22"/>
    <dbReference type="EMBL" id="ABDC03008880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597344.1">
        <property type="nucleotide sequence ID" value="XM_012741890.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQK7"/>
    <dbReference type="Ensembl" id="ENSMICT00000066801.1">
        <property type="protein sequence ID" value="ENSMICP00000049007.1"/>
        <property type="gene ID" value="ENSMICG00000011552.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858610"/>
    <dbReference type="KEGG" id="mmur:105858610"/>
    <dbReference type="CTD" id="8398"/>
    <dbReference type="GeneTree" id="ENSGT00940000158756"/>
    <dbReference type="OrthoDB" id="10021675at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031143">
        <property type="term" value="C:pseudopodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052816">
        <property type="term" value="F:long-chain fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017171">
        <property type="term" value="F:serine hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019731">
        <property type="term" value="P:antibacterial humoral response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07212">
        <property type="entry name" value="Pat_PNPLA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000338">
        <property type="entry name" value="85/88 kDa calcium-independent phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000006">
        <property type="entry name" value="85/88 kDa calcium-independent phospholipase A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047148">
        <property type="entry name" value="PLPL9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139:SF34">
        <property type="entry name" value="85_88 KDA CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24139">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 46" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 47" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="47" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="13 47" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="50" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="repeat" description="ANK" evidence="46">
        <location>
            <begin position="181"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="46">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="46">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="46">
        <location>
            <begin position="379"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="48">
        <location>
            <begin position="512"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="47">
        <location>
            <begin position="516"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="47">
        <location>
            <begin position="548"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="47">
        <location>
            <begin position="683"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="47">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="47">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00048373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00048903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="ARBA" id="ARBA00049468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="ARBA" id="ARBA00050571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="34">
        <source>
            <dbReference type="ARBA" id="ARBA00050921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="35">
        <source>
            <dbReference type="ARBA" id="ARBA00052127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="36">
        <source>
            <dbReference type="ARBA" id="ARBA00052243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="37">
        <source>
            <dbReference type="ARBA" id="ARBA00052553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="38">
        <source>
            <dbReference type="ARBA" id="ARBA00052739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="39">
        <source>
            <dbReference type="ARBA" id="ARBA00052937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="40">
        <source>
            <dbReference type="ARBA" id="ARBA00067994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="41">
        <source>
            <dbReference type="ARBA" id="ARBA00075657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="42">
        <source>
            <dbReference type="ARBA" id="ARBA00078895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="43">
        <source>
            <dbReference type="ARBA" id="ARBA00079203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="44">
        <source>
            <dbReference type="ARBA" id="ARBA00080530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="45">
        <source>
            <dbReference type="ARBA" id="ARBA00081750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="46">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="47">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="48">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="49">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="50">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="837" mass="92565" checksum="D77E72CD1A621747" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ETG5</accession>
    <name>A0A8B7ETG5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Nori-2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">TP53-regulating kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">p53-related protein kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">TP53RK</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the EKC/KEOPS complex composed of at least GON7, TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03021832">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598459.1">
        <property type="nucleotide sequence ID" value="XM_012743005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ETG5"/>
    <dbReference type="Ensembl" id="ENSMICT00000049263.2">
        <property type="protein sequence ID" value="ENSMICP00000037765.1"/>
        <property type="gene ID" value="ENSMICG00000030995.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105859290"/>
    <dbReference type="KEGG" id="mmur:105859290"/>
    <dbReference type="CTD" id="112858"/>
    <dbReference type="GeneTree" id="ENSGT00390000012914"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002039">
        <property type="term" value="F:p53 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00081359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="253" mass="28184" checksum="5C9030E4D695899B" modified="2022-01-19" version="1">MAAAVAAAPGDCEEPAPEAEALAAARERSGRFLSGLELLKQGAEARVFRGRFQGRAAVVKHRFPKGYRHPALEARLSRRRTVQEARALLRCRRAGISAPVVFFVDYASNCLYMEEIEGSVSVRDYIQSTMETEKSPQNLFGLAKTIGRVLARMHDEDLIHGDLTTSNMLLKPPMEQQNIVLIDFGLSFISALPEDKGVDLYVLEKAFLSTHPNTETVFEAFLKSYSTSSKKSRPVLKKLDEVRLRGRKRSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EW07</accession>
    <name>A0A8B7EW07_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">DHX58</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RLR subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03020165">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598701.1">
        <property type="nucleotide sequence ID" value="XM_012743247.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598703.1">
        <property type="nucleotide sequence ID" value="XM_012743249.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598704.1">
        <property type="nucleotide sequence ID" value="XM_012743250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EW07"/>
    <dbReference type="Ensembl" id="ENSMICT00000011933.3">
        <property type="protein sequence ID" value="ENSMICP00000010863.1"/>
        <property type="gene ID" value="ENSMICG00000011933.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000060455.1">
        <property type="protein sequence ID" value="ENSMICP00000050539.1"/>
        <property type="gene ID" value="ENSMICG00000011933.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859440"/>
    <dbReference type="KEGG" id="mmur:105859440"/>
    <dbReference type="CTD" id="79132"/>
    <dbReference type="GeneTree" id="ENSGT00940000153173"/>
    <dbReference type="OMA" id="IFYEPVP"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002753">
        <property type="term" value="P:cytoplasmic pattern recognition receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039534">
        <property type="term" value="P:negative regulation of MDA-5 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039536">
        <property type="term" value="P:negative regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032480">
        <property type="term" value="P:negative regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900245">
        <property type="term" value="P:positive regulation of MDA-5 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900246">
        <property type="term" value="P:positive regulation of RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12090">
        <property type="entry name" value="MDA5_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1320.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.30">
        <property type="entry name" value="RIG-I-like receptor, C-terminal regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041204">
        <property type="entry name" value="RIG-I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038557">
        <property type="entry name" value="RLR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021673">
        <property type="entry name" value="RLR_CTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051363">
        <property type="entry name" value="RLR_Helicase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074:SF7">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14074">
        <property type="entry name" value="HELICASE WITH DEATH DOMAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18119">
        <property type="entry name" value="RIG-I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11648">
        <property type="entry name" value="RIG-I_C-RD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51789">
        <property type="entry name" value="RLR_CTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="350"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="RLR CTR" evidence="19">
        <location>
            <begin position="542"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="678" mass="76600" checksum="3C96B71A4F39F3F6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EW73</accession>
    <name>A0A8B7EW73_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sperm acrosome associated 9</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4 5">Sperm acrosome-associated protein 9 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2 4 5" type="primary">SPACA9</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="4 5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="2" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599559.1">
        <property type="nucleotide sequence ID" value="XM_012744105.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599560.1">
        <property type="nucleotide sequence ID" value="XM_012744106.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599561.1">
        <property type="nucleotide sequence ID" value="XM_012744107.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599562.1">
        <property type="nucleotide sequence ID" value="XM_012744108.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EW73"/>
    <dbReference type="Ensembl" id="ENSMICT00000010626.3">
        <property type="protein sequence ID" value="ENSMICP00000009679.1"/>
        <property type="gene ID" value="ENSMICG00000010636.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859870"/>
    <dbReference type="KEGG" id="mmur:105859870"/>
    <dbReference type="CTD" id="11092"/>
    <dbReference type="GeneTree" id="ENSGT00390000007746"/>
    <dbReference type="OMA" id="EHHCYNS"/>
    <dbReference type="OrthoDB" id="9999829at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
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    <dbReference type="GO" id="GO:0005879">
        <property type="term" value="C:axonemal microtubule"/>
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        <property type="term" value="C:axonemal microtubule doublet inner sheath"/>
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    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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    <dbReference type="GO" id="GO:0097546">
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    <dbReference type="InterPro" id="IPR027818">
        <property type="entry name" value="SPACA9"/>
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        <property type="entry name" value="SPERM ACROSOME-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32455:SF1">
        <property type="entry name" value="SPERM ACROSOME-ASSOCIATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15120">
        <property type="entry name" value="SPACA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="RefSeq" id="XP_012599559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012599562.1"/>
        </source>
    </evidence>
    <sequence length="222" mass="25592" checksum="142A6739D75DFEF4" modified="2022-01-19" version="1">MNEVKESLRSIEQKYKLFQQQQFTFIAALEHCRENAHDKIRPISSIGQVQSYMEHYCNNSTDRRILLMFLDICSDLNKLCQRFEALHSGTPVTNNLLEKGKTLVSQSNDLSNLRARYPHDVVNHLSCDEARNHYGGVVSLIPIVLDLMKEWIAHSEKLPRKTLQPVSEPWALQETTGRATRPVQTTGTQLLFRKHKYRQLTRDRGKDKGCSKPPWRPPGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EYN9</accession>
    <name>A0A8B7EYN9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLCO2B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006518">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600543.1">
        <property type="nucleotide sequence ID" value="XM_012745089.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600544.1">
        <property type="nucleotide sequence ID" value="XM_012745090.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600545.1">
        <property type="nucleotide sequence ID" value="XM_012745091.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600547.1">
        <property type="nucleotide sequence ID" value="XM_012745093.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600548.1">
        <property type="nucleotide sequence ID" value="XM_012745094.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EYN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000011167.3">
        <property type="protein sequence ID" value="ENSMICP00000010171.2"/>
        <property type="gene ID" value="ENSMICG00000011163.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000053368.2">
        <property type="protein sequence ID" value="ENSMICP00000032102.2"/>
        <property type="gene ID" value="ENSMICG00000011163.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860374"/>
    <dbReference type="KEGG" id="mmur:105860374"/>
    <dbReference type="CTD" id="11309"/>
    <dbReference type="GeneTree" id="ENSGT01150000286901"/>
    <dbReference type="OrthoDB" id="5062115at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015125">
        <property type="term" value="F:bile acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015132">
        <property type="term" value="F:prostaglandin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF87">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="470"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032102.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="696" mass="75446" checksum="632C66779E97F997" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EZN7</accession>
    <name>A0A8B7EZN7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Deubiquitinating protein VCPIP1</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Valosin-containing protein p97/p47 complex-interacting protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Valosin-containing protein p97/p47 complex-interacting protein p135</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">VCPIP1</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 28">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Binds VCP and the ternary complex containing STX5A, NSFL1C and VCP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03012758">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600123.1">
        <property type="nucleotide sequence ID" value="XM_012744669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EZN7"/>
    <dbReference type="Ensembl" id="ENSMICT00000007032.3">
        <property type="protein sequence ID" value="ENSMICP00000006405.3"/>
        <property type="gene ID" value="ENSMICG00000007034.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860158"/>
    <dbReference type="KEGG" id="mmur:105860158"/>
    <dbReference type="CTD" id="80124"/>
    <dbReference type="GeneTree" id="ENSGT00390000002854"/>
    <dbReference type="OrthoDB" id="10012024at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090168">
        <property type="term" value="P:Golgi reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905634">
        <property type="term" value="P:regulation of protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22769">
        <property type="entry name" value="OTU_VCIP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000146">
        <property type="entry name" value="deubiquitinating protein VCIP135 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000004">
        <property type="entry name" value="deubiquitinating protein VCIP135 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039087">
        <property type="entry name" value="VCPIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045827">
        <property type="entry name" value="VCPIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14843">
        <property type="entry name" value="DEUBIQUITINATING PROTEIN VCIP135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14843:SF2">
        <property type="entry name" value="DEUBIQUITINATING PROTEIN VCPIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19437">
        <property type="entry name" value="VCIP135_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="25">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="726"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1027"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1115"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1190"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1058"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1145"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1164"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="24">
        <location>
            <begin position="1201"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="1211"/>
            <end position="1223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00063733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00071253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00083298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006405.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1223" mass="134389" checksum="8A10E7946BCE0DE7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F490</accession>
    <name>A0A8B7F490_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Potassium channel tetramerization domain containing 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KCTD20</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007448">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602329.1">
        <property type="nucleotide sequence ID" value="XM_012746875.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602330.1">
        <property type="nucleotide sequence ID" value="XM_012746876.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602331.1">
        <property type="nucleotide sequence ID" value="XM_012746877.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602332.1">
        <property type="nucleotide sequence ID" value="XM_012746878.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602333.1">
        <property type="nucleotide sequence ID" value="XM_012746879.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602334.1">
        <property type="nucleotide sequence ID" value="XM_012746880.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602335.1">
        <property type="nucleotide sequence ID" value="XM_012746881.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602336.1">
        <property type="nucleotide sequence ID" value="XM_012746882.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602337.1">
        <property type="nucleotide sequence ID" value="XM_012746883.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142559.1">
        <property type="nucleotide sequence ID" value="XM_020286970.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142560.1">
        <property type="nucleotide sequence ID" value="XM_020286971.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142561.1">
        <property type="nucleotide sequence ID" value="XM_020286972.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142562.1">
        <property type="nucleotide sequence ID" value="XM_020286973.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142563.1">
        <property type="nucleotide sequence ID" value="XM_020286974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F490"/>
    <dbReference type="Ensembl" id="ENSMICT00000027563.2">
        <property type="protein sequence ID" value="ENSMICP00000034439.2"/>
        <property type="gene ID" value="ENSMICG00000004661.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000052361.2">
        <property type="protein sequence ID" value="ENSMICP00000031635.1"/>
        <property type="gene ID" value="ENSMICG00000004661.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861423"/>
    <dbReference type="KEGG" id="mmur:105861423"/>
    <dbReference type="CTD" id="222658"/>
    <dbReference type="GeneTree" id="ENSGT00390000007975"/>
    <dbReference type="OrthoDB" id="10034757at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18386">
        <property type="entry name" value="BTB_POZ_KCTD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000017">
        <property type="entry name" value="BTB/POZ domain-containing protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="117"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="419" mass="47499" checksum="E09FF319FD0F7C31" modified="2022-01-19" version="1">MNVHRSSEGDRLLRQEASCLVDDTSAAAQEKETNGLASSGLHSLTYPLGPRNEDLSLDFASPPANLQFSHIMPLPDDIKGSCFQNGNKRNHEPFIAPERFGNSSVGFGTNSHFQAPEKVTLLVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISATVFRTVLDYYKTGIINCPDGISIPDLRDTCDYLCINFDFNTIRCQDLSALLHELSNDGAHKQFDHYLEELILPIMVGCAKKGERECHIVVLTDEDSVDWDEDHPPPMGEEYSQILYSSKLYRFFKYIENRDVAKTVLKERGLKNIRIGIEGYPTCKEKIKRRPGGRSEVIYNYVQRPFIQMSWEKEEGKSRHVDFQCVRSKSLTNLVAAGEDVLEDQEILMHHPPQVDELDRLNAPLSQMASNDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FBT4</accession>
    <name>A0A8B7FBT4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycine N-acyltransferase-like protein</fullName>
            <ecNumber evidence="8">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105863142</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19869"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57670"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="2.3.1.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>benzoyl-CoA + glycine = N-benzoylglycine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57369"/>
            <dbReference type="ChEBI" id="CHEBI:606565"/>
            <dbReference type="EC" id="2.3.1.71"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycine N-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03005815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605382.1">
        <property type="nucleotide sequence ID" value="XM_012749928.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605383.1">
        <property type="nucleotide sequence ID" value="XM_012749929.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FBT4"/>
    <dbReference type="Ensembl" id="ENSMICT00000044031.2">
        <property type="protein sequence ID" value="ENSMICP00000033213.1"/>
        <property type="gene ID" value="ENSMICG00000037943.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863142"/>
    <dbReference type="KEGG" id="mmur:105863142"/>
    <dbReference type="GeneTree" id="ENSGT00950000183133"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047961">
        <property type="term" value="F:glycine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047962">
        <property type="term" value="F:glycine N-benzoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000075">
        <property type="entry name" value="Glycine N-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010313">
        <property type="entry name" value="Glycine_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013652">
        <property type="entry name" value="Glycine_N-acyltransferase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015938">
        <property type="entry name" value="Glycine_N-acyltransferase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298:SF11">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15298">
        <property type="entry name" value="L-COA N-ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08444">
        <property type="entry name" value="Gly_acyl_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06021">
        <property type="entry name" value="Gly_acyl_tr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0216">Detoxification</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycine N-acyltransferase N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine N-acyltransferase C-terminal" evidence="10">
        <location>
            <begin position="206"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="295" mass="34188" checksum="7D874481999DF27B" modified="2022-01-19" version="1">MFRLQNPQMLHMLEKSLRKCLPESLKVYGTVFHMNQGNPFNLKALVDKWPDFNTVVVRPQEREMTDDFDHYTNTYLIYSKDLKNCQECLGTSDVINWKQHLQIQSSQFSLDEVIQSLAAAKFVGVKRTQCLLYMMPKTARKLVPFLLVNKNLSPESGKPKAINQEMFKRSSLEITNAALVNKFWHFGGNERSQRFIERCIQTFPTTCLLGPEGTPVSWCLMDHTGEMRMGGTLPEYRGQGLASCVSYFHCQVMENLGFPIYMHTDRANIFVQKMSHTLHYIPMPCDWNQWNCIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FNC9</accession>
    <name>A0A8B7FNC9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="25">Matrix metallopeptidase 24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">MMP24</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="19">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610265.1">
        <property type="nucleotide sequence ID" value="XM_012754811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FNC9"/>
    <dbReference type="Ensembl" id="ENSMICT00000051292.2">
        <property type="protein sequence ID" value="ENSMICP00000036297.1"/>
        <property type="gene ID" value="ENSMICG00000005999.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865873"/>
    <dbReference type="KEGG" id="mmur:105865873"/>
    <dbReference type="CTD" id="10893"/>
    <dbReference type="GeneTree" id="ENSGT00940000158315"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044331">
        <property type="term" value="P:cell-cell adhesion mediated by cadherin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098742">
        <property type="term" value="P:cell-cell adhesion via plasma-membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050965">
        <property type="term" value="P:detection of temperature stimulus involved in sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010001">
        <property type="term" value="P:glial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097150">
        <property type="term" value="P:neuronal stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000005">
        <property type="entry name" value="Matrix metallopeptidase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000001">
        <property type="entry name" value="Matrix metallopeptidase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021805">
        <property type="entry name" value="Pept_M10A_metallopeptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF138">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11857">
        <property type="entry name" value="DUF3377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="24">
        <location>
            <begin position="102"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="416"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="465"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="266"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="19">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="20">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="588" mass="67951" checksum="BDD3D61EC19523B7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FSF6</accession>
    <name>A0A8B7FSF6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysosomal alpha-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Acid maltase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GAA</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03019787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611741.1">
        <property type="nucleotide sequence ID" value="XM_012756287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FSF6"/>
    <dbReference type="Ensembl" id="ENSMICT00000004736.3">
        <property type="protein sequence ID" value="ENSMICP00000004317.2"/>
        <property type="gene ID" value="ENSMICG00000004729.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866728"/>
    <dbReference type="KEGG" id="mmur:105866728"/>
    <dbReference type="CTD" id="2548"/>
    <dbReference type="GeneTree" id="ENSGT00940000159355"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120282">
        <property type="term" value="C:autolysosome lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060048">
        <property type="term" value="P:cardiac muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002086">
        <property type="term" value="P:diaphragm contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005984">
        <property type="term" value="P:disaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046716">
        <property type="term" value="P:muscle cell cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050884">
        <property type="term" value="P:neuromuscular process controlling posture"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002026">
        <property type="term" value="P:regulation of the force of heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009888">
        <property type="term" value="P:tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043181">
        <property type="term" value="P:vacuolar sequestering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00111">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.110.10:FF:000007">
        <property type="entry name" value="Lysosomal alpha-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000072">
        <property type="entry name" value="lysosomal alpha-glucosidase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000005">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000001">
        <property type="entry name" value="Maltase-glucoamylase, intestinal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.110.10">
        <property type="entry name" value="Spasmolytic Protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017957">
        <property type="entry name" value="P_trefoil_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000519">
        <property type="entry name" value="P_trefoil_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044913">
        <property type="entry name" value="P_trefoil_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF92">
        <property type="entry name" value="LYSOSOMAL ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00088">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00018">
        <property type="entry name" value="PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57492">
        <property type="entry name" value="Trefoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00025">
        <property type="entry name" value="P_TREFOIL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51448">
        <property type="entry name" value="P_TREFOIL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 16" id="KW-0326">Glycosidase</keyword>
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        </source>
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</entry>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
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                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
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                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
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                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
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                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
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                <person name="Brown A."/>
                <person name="Sullivan B."/>
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                <person name="Brown S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Ensembl"/>
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        </source>
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</entry>
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    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Rogers J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Nucleolus</location>
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        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="78"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="14">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003480.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="40085" checksum="F6E13540C2B21888" modified="2022-01-19" version="1">MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPVDRTGRVADFTEQYNEQYGAVRTPYTMGYGESVYYNDAYGAFDYYKRYRVRSYEAVAAAAAASAYNYAEQTMSHLPQVQNTAVSSHLNSTSVDPYDRHLLPNSGAAATSAAMAAAAANTSSYYGRDRSPLRRAAAVLPTVGEGYGYGPESELSQASAAARNSLYDMARYEREQYVDRARYSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FW44</accession>
    <name>A0A8B7FW44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U5 small nuclear ribonucleoprotein TSSC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TSSC4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus. Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing. Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TSSC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613140.1">
        <property type="nucleotide sequence ID" value="XM_012757686.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FW44"/>
    <dbReference type="Ensembl" id="ENSMICT00000067031.1">
        <property type="protein sequence ID" value="ENSMICP00000050423.1"/>
        <property type="gene ID" value="ENSMICG00000044190.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105867516"/>
    <dbReference type="CTD" id="10078"/>
    <dbReference type="GeneTree" id="ENSGT00390000011846"/>
    <dbReference type="OrthoDB" id="1906282at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140313">
        <property type="term" value="F:molecular sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029338">
        <property type="entry name" value="TSSC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445">
        <property type="entry name" value="TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13445:SF3">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15264">
        <property type="entry name" value="TSSC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="66"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="167"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="258"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="386" mass="40196" checksum="70BD2C6DDF06281B" modified="2022-01-19" version="1">MSVSWTAEQSWGTPGTETTTPLPLRTFIRAPPTQHSASTTGTHPADGEVRRGLCKGVVWPWAHMAEAGTGEPSPGLEGKQGTEYDTLPSDAASLSDSDSDLSLPGGAEVEALSPGRLPGEAQEDSGPDEPSSPPRAAVQPFHLRGMSSTFSQRSHDIFDCLEGAARRAPPSVAHASGRGNRSFRQPLAPSSQPSAGGLSRAPRSPAPPKVPPVPDYVAHPERWTKYSLGDVAEASEQDNRAAALAFLGSRSLADPTHFVPSFNQDPSSCGEGRVVFTKPARGGEARPERKRVLRKGGEPGKGPSTAGGEGPVELAHLARPGSPEAEEWNSPLGGLQEVGPPSGAVHSGSTPGPPMVETVGFHGSKKRSRDHFRSKGSSPEGPGADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G733</accession>
    <name>A0A8B7G733_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Growth/differentiation factor 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GDF9</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Homodimer or heterodimer. But, in contrast to other members of this family, cannot be disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022404">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617605.1">
        <property type="nucleotide sequence ID" value="XM_012762151.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G733"/>
    <dbReference type="Ensembl" id="ENSMICT00000061232.1">
        <property type="protein sequence ID" value="ENSMICP00000040635.1"/>
        <property type="gene ID" value="ENSMICG00000032249.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869961"/>
    <dbReference type="KEGG" id="mmur:105869961"/>
    <dbReference type="CTD" id="2661"/>
    <dbReference type="GeneTree" id="ENSGT00940000159784"/>
    <dbReference type="OMA" id="TWRICVC"/>
    <dbReference type="OrthoDB" id="6427922at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001555">
        <property type="term" value="P:oocyte growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000870">
        <property type="term" value="P:regulation of progesterone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19403">
        <property type="entry name" value="TGF_beta_GDF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000012">
        <property type="entry name" value="Growth/differentiation factor 9 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015617">
        <property type="entry name" value="Growth_differentiation_fac-9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF19">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="4" id="KW-0202">Cytokine</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0339">Growth factor</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133776" description="Growth/differentiation factor 9" evidence="15">
        <location>
            <begin position="25"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="16">
        <location>
            <begin position="314"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00046703"/>
        </source>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="452" mass="50133" checksum="D73BEA2657A5F420" modified="2022-01-19" version="1">MALSSKFLLWFCCFAWLCVPSSLSSQASRGEAQIAAGAELESEAEPWSLLQPVDGRDRSGFLPPLFKVLSDGPGGAPRLQPDSRALHYMKKLYKAYATKDGIPKSNRSHLYNTVRLFTPCAQHKQAPGDQVAGILPPVDLLFDLDRVTAVERLLKSVLLYTVNHSVSLPSAVKCACNLVIKEPAPSGQSLPGAPHSFTLNSQFEFGKKHRWIEVDVTTLLQPLVGSNKKIHMSVNFTCTREQPRRPSARDGPSDVTLLVSPSLILYLNDTSARAHHSRLSLHDARRPSPGPDQRSNVSAYPVGEEAAEDGRSSRHRRGQDTVVSELKKPLVPASLNLSDYFKQFLFPQNECELHDFRLSFSQLKWDNWIVAPGRYNPRYCKGDCPRAAGHRYGSVAHTMVQNIIHETLDPSVPRSSCVPARYSPLSVLTVEPDGSIAYKEYEDMIATKCTCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GI13</accession>
    <name>A0A8B7GI13_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ heat shock protein family (Hsp40) member C13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">DNAJC13</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03000071">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622330.1">
        <property type="nucleotide sequence ID" value="XM_012766876.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000073019.1">
        <property type="protein sequence ID" value="ENSMICP00000051441.1"/>
        <property type="gene ID" value="ENSMICG00000049364.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872678"/>
    <dbReference type="CTD" id="23317"/>
    <dbReference type="GeneTree" id="ENSGT00390000017582"/>
    <dbReference type="OrthoDB" id="69656at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000641">
        <property type="term" value="P:regulation of early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902954">
        <property type="term" value="P:regulation of early endosome to recycling endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000007">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily C, member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000133">
        <property type="entry name" value="DnaJ heat shock protein family (Hsp40) member C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000072">
        <property type="entry name" value="dnaJ homolog subfamily C member 13 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044978">
        <property type="entry name" value="GRV2/DNAJC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045802">
        <property type="entry name" value="GRV2/DNAJC13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36983:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19432">
        <property type="entry name" value="RME-8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2243" mass="254365" checksum="3361B642FFDC7505" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKT8</accession>
    <name>A0A8B7GKT8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Secreted frizzled-related protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SFRP5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the secreted frizzled-related protein (sFRP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623351.1">
        <property type="nucleotide sequence ID" value="XM_012767897.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKT8"/>
    <dbReference type="Ensembl" id="ENSMICT00000062978.1">
        <property type="protein sequence ID" value="ENSMICP00000042264.1"/>
        <property type="gene ID" value="ENSMICG00000044070.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873184"/>
    <dbReference type="KEGG" id="mmur:105873184"/>
    <dbReference type="CTD" id="6425"/>
    <dbReference type="GeneTree" id="ENSGT00940000160608"/>
    <dbReference type="OrthoDB" id="5985572at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017147">
        <property type="term" value="F:Wnt-protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048546">
        <property type="term" value="P:digestive tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000051">
        <property type="term" value="P:negative regulation of non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035567">
        <property type="term" value="P:non-canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03580">
        <property type="entry name" value="NTR_Sfrp1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.2000.10:FF:000001">
        <property type="entry name" value="secreted frizzled-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.120:FF:000014">
        <property type="entry name" value="Secreted frizzled-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2000.10">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015526">
        <property type="entry name" value="Frizzled/SFRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020067">
        <property type="entry name" value="Frizzled_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036790">
        <property type="entry name" value="Frizzled_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001134">
        <property type="entry name" value="Netrin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018933">
        <property type="entry name" value="Netrin_module_non-TIMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008993">
        <property type="entry name" value="TIMP-like_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309">
        <property type="entry name" value="FRIZZLED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11309:SF46">
        <property type="entry name" value="SECRETED FRIZZLED-RELATED PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01392">
        <property type="entry name" value="Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01759">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00643">
        <property type="entry name" value="C345C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00063">
        <property type="entry name" value="FRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63501">
        <property type="entry name" value="Frizzled cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50242">
        <property type="entry name" value="TIMP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50038">
        <property type="entry name" value="FZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50189">
        <property type="entry name" value="NTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133888" description="Secreted frizzled-related protein 5" evidence="12">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="FZ" evidence="13">
        <location>
            <begin position="46"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NTR" evidence="14">
        <location>
            <begin position="179"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="61"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="315" mass="35248" checksum="E8C6C93E74AAC446" modified="2022-01-19" version="1">MRAAAGGARAAALALLLGVLHGAPARGEEYDYYGWQAEPLHGRSYSKPPQCLDIPTDLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKSGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGASEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GP17</accession>
    <name>A0A8B7GP17_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EEF2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Binds to 80S ribosomes. Actively translating ribosomes show mutually exclusive binding of eIF5a (EIF5A or EIF5A2) and EEF2/eEF2. Interacts with SERBP1; interaction sequesters EEF2/eEF2 at the A-site of the ribosome, thereby blocking the interaction sites of the mRNA-tRNA complex, promoting ribosome stabilization and hibernation. Interacts with HABP4; interaction takes place at the A-site of hibernating ribosomes and promotes ribosome stabilization. Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9. Interacts with RBPMS2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03028032">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624751.1">
        <property type="nucleotide sequence ID" value="XM_012769297.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GP17"/>
    <dbReference type="Ensembl" id="ENSMICT00000034459.2">
        <property type="protein sequence ID" value="ENSMICP00000032278.1"/>
        <property type="gene ID" value="ENSMICG00000012772.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873942"/>
    <dbReference type="KEGG" id="mmur:105873942"/>
    <dbReference type="CTD" id="1938"/>
    <dbReference type="GeneTree" id="ENSGT00940000154662"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="ELONGATNFCT"/>
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    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00046490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
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        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032278.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="858" mass="95383" checksum="E8A6A86AC5228F6E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GP19</accession>
    <name>A0A8B7GP19_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">F-box/LRR-repeat protein 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">F-box and leucine-rich repeat protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">FBXL4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007718">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012769417.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624872.1">
        <property type="nucleotide sequence ID" value="XM_012769418.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624873.1">
        <property type="nucleotide sequence ID" value="XM_012769419.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624874.1">
        <property type="nucleotide sequence ID" value="XM_012769420.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624875.1">
        <property type="nucleotide sequence ID" value="XM_012769421.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GP19"/>
    <dbReference type="Ensembl" id="ENSMICT00000066658.1">
        <property type="protein sequence ID" value="ENSMICP00000042163.1"/>
        <property type="gene ID" value="ENSMICG00000038579.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068549.1">
        <property type="protein sequence ID" value="ENSMICP00000045794.1"/>
        <property type="gene ID" value="ENSMICG00000038579.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874009"/>
    <dbReference type="KEGG" id="mmur:105874009"/>
    <dbReference type="CTD" id="26235"/>
    <dbReference type="GeneTree" id="ENSGT00940000155184"/>
    <dbReference type="OrthoDB" id="2153609at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901525">
        <property type="term" value="P:negative regulation of mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22117">
        <property type="entry name" value="F-box_FBXL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000050">
        <property type="entry name" value="F-box and leucine-rich repeat protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000152">
        <property type="entry name" value="F-box/LRR-repeat protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000417">
        <property type="entry name" value="F-box/LRR-repeat protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF152">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="15">
        <location>
            <begin position="277"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="621" mass="70552" checksum="0C475937BB0CE808" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HVD6</accession>
    <name>A0A8B7HVD6_MICMU</name>
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        <submittedName>
            <fullName evidence="4">SLAIN motif family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">SLAIN1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLAIN motif-containing family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641193.2">
        <property type="nucleotide sequence ID" value="XM_012785739.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HVD6"/>
    <dbReference type="Ensembl" id="ENSMICT00000064068.1">
        <property type="protein sequence ID" value="ENSMICP00000049378.1"/>
        <property type="gene ID" value="ENSMICG00000002711.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105882969"/>
    <dbReference type="CTD" id="122060"/>
    <dbReference type="GeneTree" id="ENSGT00390000017860"/>
    <dbReference type="OrthoDB" id="8819875at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026179">
        <property type="entry name" value="Slain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406">
        <property type="entry name" value="NASCENT POLYPEPTIDE-ASSOCIATED COMPLEX SUBUNIT ALPHA, MUSCLE-SPECIFIC FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22406:SF2">
        <property type="entry name" value="SLAIN MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15301">
        <property type="entry name" value="SLAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="43"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="390"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="577" mass="61711" checksum="1BBBF07863F56925" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HXC3</accession>
    <name>A0A8B7HXC3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">AP2B1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adaptor complexes large subunit family.</text>
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    <dbReference type="EMBL" id="ABDC03019973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012786268.3"/>
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        <property type="nucleotide sequence ID" value="XM_012786324.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012786380.2"/>
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        <property type="nucleotide sequence ID" value="XM_012786442.3"/>
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        <property type="nucleotide sequence ID" value="XM_012786517.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012786598.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012786672.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012786755.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642290.1">
        <property type="nucleotide sequence ID" value="XM_012786836.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642360.1">
        <property type="nucleotide sequence ID" value="XM_012786906.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HXC3"/>
    <dbReference type="SMR" id="A0A8B7HXC3"/>
    <dbReference type="Ensembl" id="ENSMICT00000028461.2">
        <property type="protein sequence ID" value="ENSMICP00000019829.2"/>
        <property type="gene ID" value="ENSMICG00000017045.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065493.1">
        <property type="protein sequence ID" value="ENSMICP00000046404.1"/>
        <property type="gene ID" value="ENSMICG00000017045.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883206"/>
    <dbReference type="KEGG" id="mmur:105883206"/>
    <dbReference type="CTD" id="163"/>
    <dbReference type="GeneTree" id="ENSGT00940000155206"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035904">
        <property type="term" value="P:aorta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060976">
        <property type="term" value="P:coronary vasculature development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098884">
        <property type="term" value="P:postsynaptic neurotransmitter receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003281">
        <property type="term" value="P:ventricular septum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000002">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1150:FF:000001">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000003">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015151">
        <property type="entry name" value="B-adaptin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013037">
        <property type="entry name" value="Clathrin_b-adaptin_app_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09066">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01020">
        <property type="entry name" value="B2-adapt-app_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="8">
        <location>
            <begin position="721"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-adaptin appendage C-terminal subdomain" evidence="9">
        <location>
            <begin position="840"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="951" mass="105692" checksum="3199C9F8C7F027F2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I314</accession>
    <name>A0A8B7I314_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">U6 snRNA (guanine-N(2))-methyltransferase THUMPD2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">THUMP domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">THUMPD2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>guanosine in U6 snRNA + S-adenosyl-L-methionine = N(2)-methylguanosine in U6 snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83423"/>
            <dbReference type="Rhea" id="RHEA-COMP:20128"/>
            <dbReference type="Rhea" id="RHEA-COMP:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74481"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:83424"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the heterodimeric THUMPD2-TRM112 methyltransferase complex; this complex forms an active tRNA methyltransferase, where TRMT112 acts as an activator of the catalytic subunit THUMPD2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643986.1">
        <property type="nucleotide sequence ID" value="XM_012788532.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I314"/>
    <dbReference type="Ensembl" id="ENSMICT00000008039.3">
        <property type="protein sequence ID" value="ENSMICP00000007324.2"/>
        <property type="gene ID" value="ENSMICG00000008042.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884537"/>
    <dbReference type="KEGG" id="mmur:105884537"/>
    <dbReference type="CTD" id="80745"/>
    <dbReference type="GeneTree" id="ENSGT00530000063557"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160230">
        <property type="term" value="F:U6 snRNA (guanine-N(2))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11715">
        <property type="entry name" value="THUMP_AdoMetMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.30:FF:000005">
        <property type="entry name" value="THUMP domain containing 2, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000177">
        <property type="entry name" value="THUMP domain containing 2, isoform CRA_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14911:SF1">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="13">
        <location>
            <begin position="162"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00077987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007324.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="504" mass="56159" checksum="28C6BF3E7499C075" modified="2022-01-19" version="1">MSAPPGESGPGPGAGARYFCTAGRGLEPFLMREVRARLAATQVEYTSGKVFFTTCSDVNMLKKLKSAERLFLLIKKEFPLTVSSVSKGKIFNEMQRLINNDPGSWLNAISVWRKLLELDAKKEKLSQKDANPLKRKVGENEIITAKKLKIEQLQKIEENRECQLEKQTEEETLEQRAFVTKREKFQEEAFQNDTEKATIIHNQSNLTFRVSCRCSGTVGKAFTAQEVGKVIGIAVMKQFGWKADLRNPHLEIFVHLNDIYSVVGIPVFRVPLASRAYIKTAGLRSTIAWAMASLAEIKDGAFVLDPMCGLGTILLEAAKEWPDVYYVGADVSDSQLLGACDNLQAAGLKDKIELLKVSVIELPLPSESVDIIISDIPFGKKFKLGKDIKSILQEMERVLRVGGTIVLLLSEDHHRHLKDCEESSIPLSSKNSYTDEPGIKKCLNLEETTDISETEYSAFEASNQECLDKMSPFGSLVPVECYKVSLGKTDAFIYKYKKSHSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I6G1</accession>
    <name>A0A8B7I6G1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WD repeat-containing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">WDR44</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03034422">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012791034.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7I6G1"/>
    <dbReference type="Ensembl" id="ENSMICT00000047113.2">
        <property type="protein sequence ID" value="ENSMICP00000031677.1"/>
        <property type="gene ID" value="ENSMICG00000000877.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885788"/>
    <dbReference type="KEGG" id="mmur:105885788"/>
    <dbReference type="CTD" id="54521"/>
    <dbReference type="GeneTree" id="ENSGT00940000157557"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0140313">
        <property type="term" value="F:molecular sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061824">
        <property type="term" value="P:cytosolic ciliogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of cilium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:protein localization to cilium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060627">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="600"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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            <end position="420"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
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    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
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        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
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        </location>
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            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
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            <end position="473"/>
        </location>
    </feature>
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        <location>
            <begin position="558"/>
            <end position="570"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00021207"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="Ensembl" id="ENSMICP00000031677.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="910" mass="101036" checksum="CB5A8F86F27AACAA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WV31</accession>
    <name>A0A8B7WV31_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LIM/homeobox protein Lhx5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LHX5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024539">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138665.1">
        <property type="nucleotide sequence ID" value="XM_020283076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WV31"/>
    <dbReference type="Ensembl" id="ENSMICT00000060812.1">
        <property type="protein sequence ID" value="ENSMICP00000049975.1"/>
        <property type="gene ID" value="ENSMICG00000046634.1"/>
    </dbReference>
    <dbReference type="CTD" id="64211"/>
    <dbReference type="GeneTree" id="ENSGT00940000161536"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021846">
        <property type="term" value="P:cell proliferation in forebrain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021702">
        <property type="term" value="P:cerebellar Purkinje cell differentiation"/>
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        <property type="term" value="P:cerebellar Purkinje cell-granule cell precursor cell signaling"/>
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        <property type="term" value="P:forebrain neuron differentiation"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
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        <property type="entry name" value="LIM_DOMAIN_2"/>
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    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="16">
        <location>
            <begin position="3"/>
            <end position="62"/>
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            <dbReference type="PROSITE" id="PS50071"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="402" mass="44170" checksum="3DF7BC712E98EB4D" modified="2022-01-19" version="1">MMVHCAGCERPILDRFLLNVLDRAWHIKCVQCCECKTNLSEKCFSREGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSKVFHLNCFTCMVCNKQLSTGEELYVIDENKFVCKDDYLSSSSLKEGSLNSVSSCTDRSLSPDLQDPLQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGGKGGRTTRAGSNYDFFAHGPPSQAQSPADSGFLAASGPGSTPLGALEPPLAGPHAGDNPRFTDMISHPDTPSPEPGLPGALHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHPNPELNEAAVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WWJ7</accession>
    <name>A0A8B7WWJ7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ICAM4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139528.1">
        <property type="nucleotide sequence ID" value="XM_020283939.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WWJ7"/>
    <dbReference type="Ensembl" id="ENSMICT00000044198.2">
        <property type="protein sequence ID" value="ENSMICP00000039419.2"/>
        <property type="gene ID" value="ENSMICG00000010290.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885443"/>
    <dbReference type="KEGG" id="mmur:105885443"/>
    <dbReference type="CTD" id="3386"/>
    <dbReference type="GeneTree" id="ENSGT00940000162431"/>
    <dbReference type="OrthoDB" id="10012075at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000194">
        <property type="entry name" value="Intercellular adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013768">
        <property type="entry name" value="ICAM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047012">
        <property type="entry name" value="ICAM_VCAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13771:SF8">
        <property type="entry name" value="INTERCELLULAR ADHESION MOLECULE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03921">
        <property type="entry name" value="ICAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135514" evidence="13">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Intercellular adhesion molecule N-terminal" evidence="14">
        <location>
            <begin position="47"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039419.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="296" mass="31404" checksum="465E7CC4F05747B6" modified="2022-01-19" version="1">MGSVFPLSLLLLSAAAYWGSGTVPGRRARRAQGPRESPPAPSGTSASFWVRISPQSVAVRPGVSVWLNCSHSCPLPPNSSLHTQLRRGPTLSGPGWVSYQLLDVRAWSSDVRCFVTCAGETRGATARIATYKAPHSVVLEPPVLEGGMYTLRCHVTRVFPVGFLVVTLRCGGRVIYSESLERFTGLDPANVTLTHAFPAGLRDFGQPVTCLACLSLDGLVVGSSSAPITLTLAWSPASEALAFTSVAVLVVILVAVGAAYLRRCLAMRSRRRGGVLCRLSGGKEESGTMRGTLPDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X4Z8</accession>
    <name>A0A8B7X4Z8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TNFAIP3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C64 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03008451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603517.1">
        <property type="nucleotide sequence ID" value="XM_012748063.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142811.1">
        <property type="nucleotide sequence ID" value="XM_020287222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X4Z8"/>
    <dbReference type="Ensembl" id="ENSMICT00000047758.2">
        <property type="protein sequence ID" value="ENSMICP00000020842.1"/>
        <property type="gene ID" value="ENSMICG00000013965.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862062"/>
    <dbReference type="KEGG" id="mmur:105862062"/>
    <dbReference type="CTD" id="7128"/>
    <dbReference type="GeneTree" id="ENSGT00940000158448"/>
    <dbReference type="OrthoDB" id="10064699at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001922">
        <property type="term" value="P:B-1 B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050869">
        <property type="term" value="P:negative regulation of B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000349">
        <property type="term" value="P:negative regulation of CD40 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002677">
        <property type="term" value="P:negative regulation of chronic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000352">
        <property type="term" value="P:negative regulation of endothelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902042">
        <property type="term" value="P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045824">
        <property type="term" value="P:negative regulation of innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032691">
        <property type="term" value="P:negative regulation of interleukin-1 beta production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032703">
        <property type="term" value="P:negative regulation of interleukin-2 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032715">
        <property type="term" value="P:negative regulation of interleukin-6 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070429">
        <property type="term" value="P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070433">
        <property type="term" value="P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048662">
        <property type="term" value="P:negative regulation of smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034140">
        <property type="term" value="P:negative regulation of toll-like receptor 3 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034148">
        <property type="term" value="P:negative regulation of toll-like receptor 5 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032720">
        <property type="term" value="P:negative regulation of tumor necrosis factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000347">
        <property type="term" value="P:positive regulation of hepatocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071947">
        <property type="term" value="P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035871">
        <property type="term" value="P:protein K11-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035523">
        <property type="term" value="P:protein K29-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990168">
        <property type="term" value="P:protein K33-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002634">
        <property type="term" value="P:regulation of germinal center formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032495">
        <property type="term" value="P:response to muramyl dipeptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072573">
        <property type="term" value="P:tolerance induction to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22766">
        <property type="entry name" value="OTU_TNFAIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000011">
        <property type="entry name" value="tumor necrosis factor alpha-induced protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.30:FF:000001">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.30:FF:000003">
        <property type="entry name" value="Tumor necrosis factor alpha-induced protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.30:FF:000004">
        <property type="entry name" value="tumor necrosis factor alpha-induced protein 3 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.30:FF:000002">
        <property type="entry name" value="Tumor necrosis factor, alpha-induced protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF3">
        <property type="entry name" value="TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="18">
        <location>
            <begin position="92"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="19">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="19">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="19">
        <location>
            <begin position="603"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="19">
        <location>
            <begin position="653"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="A20-type" evidence="19">
        <location>
            <begin position="758"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="548"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="691"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="792" mass="89692" checksum="859EB30EDD4610BC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X7B1</accession>
    <name>A0A8B7X7B1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Septin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SEPTIN2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Filament-forming cytoskeletal GTPase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Septins polymerize into heterooligomeric protein complexes that form filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cleavage furrow</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 17">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X7B1"/>
    <dbReference type="Ensembl" id="ENSMICT00000000909.3">
        <property type="protein sequence ID" value="ENSMICP00000000820.3"/>
        <property type="gene ID" value="ENSMICG00000000909.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000028847.2">
        <property type="protein sequence ID" value="ENSMICP00000032891.1"/>
        <property type="gene ID" value="ENSMICG00000000909.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155098"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032391">
        <property type="term" value="C:photoreceptor connecting cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031105">
        <property type="term" value="C:septin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097227">
        <property type="term" value="C:sperm annulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002036">
        <property type="term" value="P:regulation of L-glutamate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000064">
        <property type="entry name" value="Septin 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008113">
        <property type="entry name" value="Septin2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01740">
        <property type="entry name" value="SEPTIN2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 16 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="18">
        <location>
            <begin position="34"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="site" description="Important for dimerization" evidence="16">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR006698-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000820.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="361" mass="41505" checksum="337321EA41817E37" modified="2022-01-19" version="1">MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERIIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFLSPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVESEDMNKDQILLEKEAELRRMQEMIARMQAQMQMQMQGGDGDSGALGHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJP0</accession>
    <name>A0A8C5UJP0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 672</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017156">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145820.1">
        <property type="nucleotide sequence ID" value="XM_020290231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJP0"/>
    <dbReference type="Ensembl" id="ENSMICT00000000268.3">
        <property type="protein sequence ID" value="ENSMICP00000000244.2"/>
        <property type="gene ID" value="ENSMICG00000000269.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105865728"/>
    <dbReference type="KEGG" id="mmur:109729197"/>
    <dbReference type="GeneTree" id="ENSGT01150000286944"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000848">
        <property type="entry name" value="Zinc finger protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000399">
        <property type="entry name" value="zinc finger protein 521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001468">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002331">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003130">
        <property type="entry name" value="Zinc finger protein 672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000585">
        <property type="entry name" value="zinc finger protein 784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF54">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000244.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="460" mass="51081" checksum="0DC8F6BF96EC08A4" modified="2022-01-19" version="1">MFSAPGAVTSGRPYACSECGKSFRYSSVLLRHERAHVGDGSVHCLECGERCARAADLRAHRRTHAGQTLYICGECGLSFSHSGRLDLHMGIHRCLRSRTCLCRICGRHLPHLLALLVHRRHRHPPERPRRCPLCARAFRQSALAFHQARAHAPGTPSAPADPPHRCKQCPRAFRSSTGLRSHARVHMVQSPTRQLPLEPDTHQCGVCGKSFSKSSTLTRHLQTHSGEKPFKCPACGKGFLESATLVRHQRTHTGEKPYACGDCGRCFSESSTLLRHRRSHQGERPHACATCGKGFGQRSDLVVHQRIHTGEKPFPCPECSRRFSDRSDLTKHRRTHTGEKPYRCELCGKRFTCVSNLNVHRRNHAGHKPHKCPECGKAFSVASKLALHRKTHLGERPAKCAECGKCFSHSRSLSQHQRAHTRARTAAAATQATAGAALVFAGPTEQEKPGLFMSQLRETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM03</accession>
    <name>A0A8C5UM03_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thioredoxin domain-containing protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Spermatid-specific thioredoxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TXNDC2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03023074">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UM03"/>
    <dbReference type="Ensembl" id="ENSMICT00000002882.3">
        <property type="protein sequence ID" value="ENSMICP00000002625.3"/>
        <property type="gene ID" value="ENSMICG00000002887.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163147"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000224">
        <property type="entry name" value="Thioredoxin domain containing 2 (Spermatozoa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Thioredoxin" evidence="14">
        <location>
            <begin position="419"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="78"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="145"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="111"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="163"/>
            <end position="174"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="366"/>
            <end position="375"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080017"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002625.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="552" mass="60833" checksum="CD0B1201CF1610F4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM71</accession>
    <name>A0A8C5UM71_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Roundabout homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">ROBO3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Receptor involved in axon guidance during development. Acts as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion, inhibits SLIT repulsion, and facilitates Netrin-1/NTN1 attraction. In spinal cord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1/ROBO2. Binding OF NELL2 to the receptor ROBO3 promotes oligomerization of ROBO3, resulting in the repulsion of commissural axons in the midline. ROBO3 also indirectly boosts axon attraction to NTN1 without interacting with NTN1 itself.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the immunoglobulin superfamily. ROBO family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012607975.1">
        <property type="nucleotide sequence ID" value="XM_012752521.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000001705.3">
        <property type="protein sequence ID" value="ENSMICP00000001550.3"/>
        <property type="gene ID" value="ENSMICG00000001703.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864562"/>
    <dbReference type="KEGG" id="mmur:105864562"/>
    <dbReference type="CTD" id="64221"/>
    <dbReference type="GeneTree" id="ENSGT00940000155457"/>
    <dbReference type="OrthoDB" id="428111at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016199">
        <property type="term" value="P:axon midline choice point recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071679">
        <property type="term" value="P:commissural neuron axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050925">
        <property type="term" value="P:negative regulation of negative chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001764">
        <property type="term" value="P:neuron migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="Roundabout guidance receptor 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="roundabout homolog 2 isoform X1"/>
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        <property type="entry name" value="roundabout homolog 2 isoform X2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="entry name" value="FN3_dom"/>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Ig-like_dom"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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    <dbReference type="InterPro" id="IPR051170">
        <property type="entry name" value="Neural/epithelial_adhesion"/>
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        <property type="entry name" value="CTX-RELATED TYPE I TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ROUNDABOUT HOMOLOG 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="fn3"/>
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        <property type="entry name" value="Ig_3"/>
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        <property type="entry name" value="IG"/>
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        <property type="entry name" value="IGc2"/>
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        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149844" description="Roundabout homolog 3" evidence="20">
        <location>
            <begin position="21"/>
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    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="450"/>
            <end position="533"/>
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    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="558"/>
            <end position="652"/>
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            <begin position="671"/>
            <end position="766"/>
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    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="771"/>
            <end position="867"/>
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        <location>
            <begin position="542"/>
            <end position="563"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="639"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="963"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1033"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1158"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1178"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1294"/>
            <end position="1304"/>
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    </feature>
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        <location>
            <begin position="1333"/>
            <end position="1344"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1345"/>
            <end position="1379"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00054174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001550.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1388" mass="148420" checksum="90F269CA279AD5D1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQ52</accession>
    <name>A0A8C5UQ52_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 12">AP-4 complex subunit mu-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">AP4M1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1). Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins such as APP, ATG9A, LAMP2 and NAGPA. Interacts with the C-terminal domain of GRID2. Interacts with GRIA1 and GRIA2; the interaction is indirect via CACNG3. Interacts with CACNG3; CACNG3 associates GRIA1 and GRIA2 with the adaptor protein complex 4 (AP-4) to target them to the somatodendritic compartment of neurons. Interacts with HOOK1 and HOOK2; the interactions are direct, mediate the interaction between FTS-Hook-FHIP (FHF) complex and AP-4 and the perinuclear distribution of AP-4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">trans-Golgi network membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQ52"/>
    <dbReference type="Ensembl" id="ENSMICT00000003987.3">
        <property type="protein sequence ID" value="ENSMICP00000003632.3"/>
        <property type="gene ID" value="ENSMICG00000003981.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159929"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14838">
        <property type="entry name" value="AP4_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000021">
        <property type="entry name" value="AP-4 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000018">
        <property type="entry name" value="AP-4 complex subunit mu-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="7 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="193"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00041045"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00045641"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00046433"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003632.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="465" mass="51254" checksum="8148F3812B8B21BC" modified="2022-01-19" version="1">MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTAEGGGWRHHDDRHFIHIRHSGLYLVATTSENVSPFSLLELLSRLATLLGDYCGSLSEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEPVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRTDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEIRIGLTEEFCVGKSELRGENVALLSFQVMVLCTWMSLSLIESSALFYPPWGREAVQLTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLPPKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELGEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSQGPSTSAPPLGLGPASLSFELPRHTCSGLQVRFLRLTFRPCGNANPHKWVRHLSHSDAYVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5USC0</accession>
    <name>A0A8C5USC0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Calaxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLXN</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03012406">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5USC0"/>
    <dbReference type="Ensembl" id="ENSMICT00000006461.3">
        <property type="protein sequence ID" value="ENSMICP00000005901.3"/>
        <property type="gene ID" value="ENSMICG00000006465.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159968"/>
    <dbReference type="OMA" id="DNDGCVS"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF75">
        <property type="entry name" value="CALAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="101"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005901.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="212" mass="24583" checksum="1C9FA950A2EB5570" modified="2022-01-19" version="1">MNRKKLQKLTDTLTKNCKHFNTFEVNCLIKLFYNLVGEGVERQGTTIGLDRNAFRNILHVTFGMTDDMIMDRVFRGFDKDNDGCVNVTEWVCGLSLFLRGSLEEKMKYCFEVFDLNGDGFISKEEMFHMLKNSLLKQPSEEDPDEGIKDLVEITLKKMDYDHDGKLSFADYEQAVREETLLLEAFGPCLPDPKSQMEFEAQVFKDPHDFNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5USU5</accession>
    <name>A0A8C5USU5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Oncostatin-M-specific receptor subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Interleukin-31 receptor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">OSMR</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="11">Heterodimer composed of OSMR and IL6ST (type II OSM receptor). Heterodimer with IL31RA to form the IL31 receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5USU5"/>
    <dbReference type="Ensembl" id="ENSMICT00000006665.3">
        <property type="protein sequence ID" value="ENSMICP00000006084.3"/>
        <property type="gene ID" value="ENSMICG00000006658.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160851"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004896">
        <property type="term" value="F:cytokine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038165">
        <property type="term" value="P:oncostatin-M-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000578">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000607">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000657">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000738">
        <property type="entry name" value="Leukemia inhibitory factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001148">
        <property type="entry name" value="oncostatin-M-specific receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001286">
        <property type="entry name" value="Oncostatin-M-specific receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001289">
        <property type="entry name" value="Oncostatin-M-specific receptor subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003529">
        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048497">
        <property type="entry name" value="LIF-R-like_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040817">
        <property type="entry name" value="LIFR_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF1">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21177">
        <property type="entry name" value="LIF-R_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17971">
        <property type="entry name" value="LIFR_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25552">
        <property type="entry name" value="LIFR_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01353">
        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034080327" description="Oncostatin-M-specific receptor subunit beta" evidence="16">
        <location>
            <begin position="28"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="333"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="431"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="17">
        <location>
            <begin position="621"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="954"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00079310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006084.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="976" mass="110251" checksum="B503C13BEE0541BB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UT72</accession>
    <name>A0A8C5UT72_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Neuronal acetylcholine receptor subunit beta-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CHRNB4</name>
        <name evidence="12" type="synonym">LOC105857200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Neuronal AChR is composed of two different types of subunits: alpha and beta. CHRNB4/Beta-4 subunit can be combined to CHRNA2/alpha-2, CHRNA3/alpha-3 or CHRNA4/alpha-4, CHRNA5/alpha-5 and CHRNB3/beta-3 to give rise to functional receptors. Forms stoichiometries such as (CHRNA3)2:(CHRNB4)3 or (CHRNA3:CHRNB4)2:CHRNB3. Interacts with RIC3; which is required for proper folding and assembly. Interacts with LYPD6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004955">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004956">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UT72"/>
    <dbReference type="Ensembl" id="ENSMICT00000005784.3">
        <property type="protein sequence ID" value="ENSMICP00000005276.3"/>
        <property type="gene ID" value="ENSMICG00000005789.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158708"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098981">
        <property type="term" value="C:cholinergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098878">
        <property type="term" value="C:neurotransmitter receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099634">
        <property type="term" value="C:postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015464">
        <property type="term" value="F:acetylcholine receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035095">
        <property type="term" value="P:behavioral response to nicotine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051971">
        <property type="term" value="P:positive regulation of transmission of nerve impulse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006940">
        <property type="term" value="P:regulation of smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006939">
        <property type="term" value="P:smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060084">
        <property type="term" value="P:synaptic transmission involved in micturition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000028">
        <property type="entry name" value="AcetylCholine Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000008">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000034">
        <property type="entry name" value="Cholinergic receptor nicotinic beta 4 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="10">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="10">
        <location>
            <begin position="85"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="11">
        <location>
            <begin position="243"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005276.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="502" mass="56054" checksum="E7F6D931B559A5D6" modified="2022-01-19" version="1">MDDLLNKTRYNSLIRPATSSSQLISIQLQLSLAQLISVNEREQIMTTNVWLKQVSALQGPQPRRCFLQSCPSIVMDLQVTGPCLSVQEWTDYRLAWNSSRYEGVNILRIPARRIWLPDIVLYNNADGTYEVSVYTNVVVRSNGSVQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLMSPTASMDDFTPSGEWDIMALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIAPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPSTHTMAPWVKRCFLHKLPSFLYMKRPGPASSPARAPQPGQSRLLKTEATTSAASAVGPASPSSPCGHSMYCVSSGSAAPKSPARPDSGALRLRSSGRFRQDVQEALEGVSFIAQHMKSDDQDQSVVEDWKYVAMVVDRLFLWVFVFVCILGTVGLFLPPLFQTHTPSEGPSLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTY2</accession>
    <name>A0A8C5UTY2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Plexin-A2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PLXNA2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029927">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614217.1">
        <property type="nucleotide sequence ID" value="XM_012758763.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139995.1">
        <property type="nucleotide sequence ID" value="XM_020284406.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000007792.3">
        <property type="protein sequence ID" value="ENSMICP00000007092.2"/>
        <property type="gene ID" value="ENSMICG00000007782.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868172"/>
    <dbReference type="KEGG" id="mmur:105868172"/>
    <dbReference type="CTD" id="5362"/>
    <dbReference type="GeneTree" id="ENSGT01050000244850"/>
    <dbReference type="OrthoDB" id="125363at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021935">
        <property type="term" value="P:cerebellar granule cell precursor tangential migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060174">
        <property type="term" value="P:limb bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060037">
        <property type="term" value="P:pharyngeal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00603">
        <property type="entry name" value="IPT_PCSR"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVC9</accession>
    <name>A0A8C5UVC9_MICMU</name>
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            <fullName evidence="11">Nuclear pore complex protein Nup214</fullName>
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            <fullName evidence="13">214 kDa nucleoporin</fullName>
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            <fullName evidence="12">Nucleoporin Nup214</fullName>
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        <name evidence="17" type="primary">NUP214</name>
        <name evidence="17" type="synonym">AIF1L</name>
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    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="9">Part of the nuclear pore complex. Has a critical role in nucleocytoplasmic transport. May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex.</text>
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        <text evidence="10">Homodimer. Part of the nuclear pore complex (NPC). Interacts with NUP88. Interacts with ZFP36; this interaction increases upon lipopolysaccharide (LPS) stimulation. Interacts with DDX19. Interacts with XPO1. Interacts with XPO5.</text>
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        <subcellularLocation>
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            <location evidence="1">Nuclear pore complex</location>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007098.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2097" mass="214393" checksum="124DA6A2FA1E9711" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVS6</accession>
    <name>A0A8C5UVS6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ATP6V1G3</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599943.1">
        <property type="nucleotide sequence ID" value="XM_012744489.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVS6"/>
    <dbReference type="Ensembl" id="ENSMICT00000009380.3">
        <property type="protein sequence ID" value="ENSMICP00000008540.2"/>
        <property type="gene ID" value="ENSMICG00000009388.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860071"/>
    <dbReference type="KEGG" id="mmur:105860071"/>
    <dbReference type="CTD" id="127124"/>
    <dbReference type="GeneTree" id="ENSGT00940000160882"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097401">
        <property type="term" value="P:synaptic vesicle lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF5">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008540.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="118" mass="13776" checksum="C97EB3FC81A78CE6" modified="2022-01-19" version="1">MTSQSQGIHHLLQAEKRAKDKLEEAKKRKGKRLKQAKEEAMAEIDQYRMQKEKEFRLKQSKMMGSQSNLSGEIEEETRGKIQELNGRYNKHVESVMQQLLGMVCDMKPEIHVNYRAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWU1</accession>
    <name>A0A8C5UWU1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Latent-transforming growth factor beta-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Transforming growth factor beta-1-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">LTBP1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1. LTBP1 does not bind directly to TGF-beta-1, the active chain of TGFB1. Interacts (via C-terminal domain) with FBN1 (via N-terminal domain). Interacts with FBN2. Interacts with ADAMTSL2. Interacts with EFEMP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LTBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000009596.3">
        <property type="protein sequence ID" value="ENSMICP00000008734.3"/>
        <property type="gene ID" value="ENSMICG00000009581.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155823"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001527">
        <property type="term" value="C:microfibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050436">
        <property type="term" value="F:microfibril binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141069">
        <property type="term" value="F:receptor ligand inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050431">
        <property type="term" value="F:transforming growth factor beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035592">
        <property type="term" value="P:establishment of protein localization to extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035583">
        <property type="term" value="P:sequestering of TGFbeta in extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000198">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000205">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000004">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000019">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000046">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 1 isoform x2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.290.10:FF:000012">
        <property type="entry name" value="latent-transforming growth factor beta-binding protein 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Putative latent-transforming growth factor beta-binding protein 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Laminin"/>
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        <property type="entry name" value="TGF-beta binding (TB) domain"/>
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    </dbReference>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
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        <property type="entry name" value="EGF_Ca-bd_CS"/>
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        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Nephronectin_domain"/>
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        <property type="entry name" value="NOTCH1_EGF-like"/>
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        <property type="entry name" value="TB_dom"/>
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    <dbReference type="InterPro" id="IPR036773">
        <property type="entry name" value="TB_dom_sf"/>
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    <dbReference type="PANTHER" id="PTHR24050:SF27">
        <property type="entry name" value="FIBRILLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24050">
        <property type="entry name" value="PA14 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
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        <property type="entry name" value="TB"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF/Laminin"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="11"/>
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        <property type="entry name" value="EGF_2"/>
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        <property type="entry name" value="EGF_3"/>
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        <property type="entry name" value="EGF_CA"/>
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        <property type="entry name" value="TB"/>
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    <keyword evidence="4 17" id="KW-0245">EGF-like domain</keyword>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034265203" description="Latent-transforming growth factor beta-binding protein 1" evidence="19">
        <location>
            <begin position="24"/>
            <end position="1717"/>
        </location>
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        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
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        <location>
            <begin position="555"/>
            <end position="600"/>
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    </feature>
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        <location>
            <begin position="624"/>
            <end position="661"/>
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    </feature>
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        <location>
            <begin position="675"/>
            <end position="727"/>
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    </feature>
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            <begin position="913"/>
            <end position="954"/>
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    </feature>
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        <location>
            <begin position="1036"/>
            <end position="1076"/>
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            <begin position="1077"/>
            <end position="1117"/>
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            <begin position="1118"/>
            <end position="1158"/>
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    <feature type="domain" description="EGF-like" evidence="20">
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            <begin position="1159"/>
            <end position="1199"/>
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    </feature>
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        <location>
            <begin position="1200"/>
            <end position="1241"/>
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        <location>
            <begin position="1242"/>
            <end position="1279"/>
        </location>
    </feature>
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        <location>
            <begin position="1343"/>
            <end position="1397"/>
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    </feature>
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            <begin position="1520"/>
            <end position="1573"/>
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            <begin position="1658"/>
            <end position="1702"/>
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    </feature>
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            <begin position="63"/>
            <end position="156"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="228"/>
            <end position="258"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
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            <begin position="748"/>
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    </feature>
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        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="99"/>
            <end position="109"/>
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            <begin position="117"/>
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            <begin position="419"/>
            <end position="428"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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            <dbReference type="ARBA" id="ARBA00022530"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022729"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00072992"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00075443"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008734.3"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="1717" mass="186946" checksum="7C2A488AD521397E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UYA0</accession>
    <name>A0A8C5UYA0_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Endoplasmic reticulum protein SC65</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leprecan-like protein 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Prolyl 3-hydroxylase family member 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Synaptonemal complex protein SC65</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">P3H4</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with PLOD1, P3H3 and PPIB. Identified in a complex with PLOD1 and P3H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the leprecan family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000011835.3">
        <property type="protein sequence ID" value="ENSMICP00000010776.3"/>
        <property type="gene ID" value="ENSMICG00000011838.3"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005518">
        <property type="term" value="F:collagen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046849">
        <property type="term" value="P:bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032964">
        <property type="term" value="P:collagen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="synaptonemal complex protein SC65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052284">
        <property type="entry name" value="Collagen_mod_leprecan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056585">
        <property type="entry name" value="Leprecan_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986:SF4">
        <property type="entry name" value="ENDOPLASMIC RETICULUM PROTEIN SC65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13986">
        <property type="entry name" value="PROTEIN LYSINE HYDROXYLATION COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23557">
        <property type="entry name" value="TPR_leprecan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034357999" description="Endoplasmic reticulum protein SC65" evidence="13">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Leprecan-like alpha-helical" evidence="14">
        <location>
            <begin position="35"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="382"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010776.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="437" mass="50217" checksum="B1BBC03D811AF113" modified="2022-01-19" version="1">MGRAAWGLLWLLLGSAGAQYEKYSFRGFPPEDLMPLAAAYGHALELYEGESWRESARYLEAALRLHRLLRDSEAFCHANCSGPAPAPAPGPDGGGDDEWARELWLFGHVLERAACLRRCKRTLPAFQVPYPPRQLLRDFQSRLPYQYLHYALFKANRLEKAVAAAYTFLQRNPKHELTAKYLSYYRGMLDIADDALTDLEAQPYEAVFLRAVKLYNSGDFRSSTEDMERALAEYLAVFARCLAGCEGAHEQVDFKDFYPAIADLFAESLQCKVDCETNLTPNVGGYFVDKFVATMYHYLQFAYYKLNDVRQAARSAASYMLFDPKDSVMQQNLVYYRFHRARWGLEEEDFQPREEATLYHNQTSELRELLEFTRMYLQSDDEMEVEETELPTHSKDAPSDAEFEGEGDYEESIYADWWQEPDAKGDEAEAEPEPDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZI7</accession>
    <name>A0A8C5UZI7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="21">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">MAN1C1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A1,2,3B1,2,3) + 4 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 4 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56008"/>
            <dbReference type="Rhea" id="RHEA-COMP:14356"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:139493"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(4)-(alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A1,2,3B1,3) + 3 H2O = N(4)-(alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + 3 beta-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:56028"/>
            <dbReference type="Rhea" id="RHEA-COMP:14358"/>
            <dbReference type="Rhea" id="RHEA-COMP:14367"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28563"/>
            <dbReference type="ChEBI" id="CHEBI:59087"/>
            <dbReference type="ChEBI" id="CHEBI:60628"/>
            <dbReference type="EC" id="3.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03001831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001832">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZI7"/>
    <dbReference type="Ensembl" id="ENSMICT00000012131.3">
        <property type="protein sequence ID" value="ENSMICP00000011043.3"/>
        <property type="gene ID" value="ENSMICG00000012135.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159312"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000017">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF28">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE 1,2-ALPHA-MANNOSIDASE IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 20" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="73"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="18">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="18">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="569"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="412"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011043.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="577" mass="65648" checksum="573391793301654D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V000</accession>
    <name>A0A8C5V000_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Transient receptor potential cation channel subfamily V member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TRPV2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020641">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020642">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020643">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020644">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V000"/>
    <dbReference type="Ensembl" id="ENSMICT00000007182.3">
        <property type="protein sequence ID" value="ENSMICP00000006545.3"/>
        <property type="gene ID" value="ENSMICG00000007177.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158512"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000018">
        <property type="entry name" value="Transient receptor potential cation channel subfamily V member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008347">
        <property type="entry name" value="TrpV1-4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00870">
        <property type="entry name" value="trp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF5">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01768">
        <property type="entry name" value="TRPVRECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="18">
        <location>
            <begin position="391"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006545.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="762" mass="85643" checksum="0704DC67C22C4364" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1H6</accession>
    <name>A0A8C5V1H6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Atypical kinase COQ8A, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Chaperone activity of bc1 complex-like</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Coenzyme Q protein 8A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">aarF domain-containing protein kinase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">COQ8A</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3. According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. However, the small molecule kinase activity was not confirmed by another publication. Shows an unusual selectivity for binding ADP over ATP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021201">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606776.1">
        <property type="nucleotide sequence ID" value="XM_012751322.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1H6"/>
    <dbReference type="Ensembl" id="ENSMICT00000013446.3">
        <property type="protein sequence ID" value="ENSMICP00000012262.2"/>
        <property type="gene ID" value="ENSMICG00000013440.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863818"/>
    <dbReference type="KEGG" id="mmur:105863818"/>
    <dbReference type="CTD" id="56997"/>
    <dbReference type="GeneTree" id="ENSGT00940000156810"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF1">
        <property type="entry name" value="ATYPICAL KINASE COQ8A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="20">
        <location>
            <begin position="296"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012262.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="644" mass="71700" checksum="5757E36341E3DA77" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3G9</accession>
    <name>A0A8C5V3G9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">STK39</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03011112">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011113">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3G9"/>
    <dbReference type="Ensembl" id="ENSMICT00000012420.3">
        <property type="protein sequence ID" value="ENSMICP00000011310.3"/>
        <property type="gene ID" value="ENSMICG00000012416.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154621"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019870">
        <property type="term" value="F:potassium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071476">
        <property type="term" value="P:cellular hypotonic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035865">
        <property type="term" value="P:cellular response to potassium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038146">
        <property type="term" value="P:chemokine (C-X-C motif) ligand 12 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030644">
        <property type="term" value="P:intracellular chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042116">
        <property type="term" value="P:macrophage activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036438">
        <property type="term" value="P:maintenance of lens transparency"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090188">
        <property type="term" value="P:negative regulation of pancreatic juice secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901380">
        <property type="term" value="P:negative regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902306">
        <property type="term" value="P:negative regulation of sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900745">
        <property type="term" value="P:positive regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010820">
        <property type="term" value="P:positive regulation of T cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008217">
        <property type="term" value="P:regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070294">
        <property type="term" value="P:renal sodium ion absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904044">
        <property type="term" value="P:response to aldosterone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002021">
        <property type="term" value="P:response to dietary excess"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035725">
        <property type="term" value="P:sodium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000114">
        <property type="entry name" value="serine/threonine-protein kinase OSR1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000068">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000357">
        <property type="entry name" value="STE20/SPS1-related proline-alanine-rich protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF14">
        <property type="entry name" value="STE20_SPS1-RELATED PROLINE-ALANINE-RICH PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="67"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011310.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="524" mass="57908" checksum="06CA140BACB6AB01" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V4Q6</accession>
    <name>A0A8C5V4Q6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Centromere protein H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">CENPH</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-H/MCM16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016056">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V4Q6"/>
    <dbReference type="Ensembl" id="ENSMICT00000013443.3">
        <property type="protein sequence ID" value="ENSMICP00000012260.3"/>
        <property type="gene ID" value="ENSMICG00000013448.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009578"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040034">
        <property type="entry name" value="CENP-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008426">
        <property type="entry name" value="CENP-H_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48122:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05837">
        <property type="entry name" value="CENP-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere protein H C-terminal" evidence="10">
        <location>
            <begin position="39"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012260.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="227" mass="26046" checksum="AB4CD24B91443E8F" modified="2022-01-19" version="1">METQPEEEGAPEPADCAGAGGPPQAAGAQEARSEDRLTLLLRLRAQTKQQLLEYKSMVDTKIEDLENEIEGVKITLEMKNLTLDRMQLSTALKKHLEKINIKTSVLMDNMKQILNLNKLIMKSQQESWDLEEKLLDVRKKRLQLKQASESKLLEIQTEKNKQKNDLDNMENSEKIKIMQQNLQKEIHITTVIQHVFQNLILGSKVNWAEDSAFKETVLQLEKNLTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9H8</accession>
    <name>A0A8C5V9H8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein prenyltransferase alpha subunit repeat containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PTAR1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014405">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9H8"/>
    <dbReference type="Ensembl" id="ENSMICT00000039934.2">
        <property type="protein sequence ID" value="ENSMICP00000017864.1"/>
        <property type="gene ID" value="ENSMICG00000001040.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017892"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008318">
        <property type="term" value="F:protein prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000003">
        <property type="entry name" value="Protein prenyltransferase alpha subunit repeat containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF3">
        <property type="entry name" value="PROTEIN PRENYLTRANSFERASE ALPHA SUBUNIT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="401" mass="46249" checksum="8B2648D6BBBC8EE6" modified="2022-01-19" version="1">MAETSEEVAVLVQRVVKDITNAFRRNPHIDEIGLIPCPEARYNRSPIVLVENKLGVESWCVKFLLPYVHNKLLLYRTRKQWLNRDELIDVTCTLLLLNPDFTTAWNVRKELILSGTLNPIKDLHLGKLALTKFPKSPETWIHRRWVLQQLIQETSLPSFVTKGNLGTIPAERTLRLIQEEMEVCGEAAGRYPSNYNAWSHRIWVLQHVAKLDVKILLDELSSTKHWASLHVSDHSGFHYRQFLLKSLISQTVIDNSVLEQNPLRSEPALLPKDEEAAASTEEPRINLPHLLEEEVEFSTDLIDSYPGHETLWCHRRHVFYLQHHLHAGPQLSQAMEVDGLNDSSKQGYSQETKRLKRTPAADSLGLEMEHRFIDQVLSTCRDVEQARFANAYRKWLVTLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9L5</accession>
    <name>A0A8C5V9L5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC105867092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003006">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018502">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036072">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612324.1">
        <property type="nucleotide sequence ID" value="XM_012756870.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9L5"/>
    <dbReference type="Ensembl" id="ENSMICT00000032703.2">
        <property type="protein sequence ID" value="ENSMICP00000016723.1"/>
        <property type="gene ID" value="ENSMICG00000042557.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000043639.2">
        <property type="protein sequence ID" value="ENSMICP00000035484.1"/>
        <property type="gene ID" value="ENSMICG00000044161.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000060419.1">
        <property type="protein sequence ID" value="ENSMICP00000045421.1"/>
        <property type="gene ID" value="ENSMICG00000046505.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105858676"/>
    <dbReference type="KEGG" id="mmur:105867092"/>
    <dbReference type="KEGG" id="mmur:105872984"/>
    <dbReference type="CTD" id="54460"/>
    <dbReference type="GeneTree" id="ENSGT00500000045038"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1150:FF:000002">
        <property type="entry name" value="28S ribosomal protein S21, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="Ribosomal_bS21_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10676" checksum="2783C38519215200" modified="2022-01-19" version="1">MANHLKFIARTVMVQEGNVEGAYRTLNRILTMDGLIEDIKRRRYYEKPCRRRQRESYETCRRIYNMEMARKIKFLMRKNRADPWQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCZ9</accession>
    <name>A0A8C5VCZ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 56</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Tetratricopeptide repeat protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">IFT56</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Not required for IFT complex A ciliary localization or function. Essential for maintaining proper microtubule organization within the ciliary axoneme.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the IFT complex B. Interacts with IFT46; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT56 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015167">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623423.1">
        <property type="nucleotide sequence ID" value="XM_012767969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VCZ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000045430.2">
        <property type="protein sequence ID" value="ENSMICP00000020495.1"/>
        <property type="gene ID" value="ENSMICG00000003109.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873218"/>
    <dbReference type="KEGG" id="mmur:105873218"/>
    <dbReference type="CTD" id="79989"/>
    <dbReference type="GeneTree" id="ENSGT00390000000159"/>
    <dbReference type="OrthoDB" id="95390at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097546">
        <property type="term" value="C:ciliary base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120170">
        <property type="term" value="F:intraciliary transport particle B binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035082">
        <property type="term" value="P:axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035720">
        <property type="term" value="P:intraciliary anterograde transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905198">
        <property type="term" value="P:manchette assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061512">
        <property type="term" value="P:protein localization to cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000588">
        <property type="entry name" value="Intraflagellar transport protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000136">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000271">
        <property type="entry name" value="Tetratricopeptide repeat domain 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030511">
        <property type="entry name" value="TTC26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14781:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="554" mass="64300" checksum="F5D8C47D1FA6F635" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDU3</accession>
    <name>A0A8C5VDU3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Plakophilin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PKP3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Desmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the beta-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005922">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625024.1">
        <property type="nucleotide sequence ID" value="XM_012769570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDU3"/>
    <dbReference type="Ensembl" id="ENSMICT00000027421.2">
        <property type="protein sequence ID" value="ENSMICP00000020620.1"/>
        <property type="gene ID" value="ENSMICG00000032212.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874068"/>
    <dbReference type="KEGG" id="mmur:105874068"/>
    <dbReference type="CTD" id="11187"/>
    <dbReference type="GeneTree" id="ENSGT00940000159515"/>
    <dbReference type="OrthoDB" id="9529944at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001533">
        <property type="term" value="C:cornified envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030057">
        <property type="term" value="C:desmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045294">
        <property type="term" value="F:alpha-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050839">
        <property type="term" value="F:cell adhesion molecule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002159">
        <property type="term" value="P:desmosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902373">
        <property type="term" value="P:negative regulation of mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022409">
        <property type="term" value="P:positive regulation of cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000199">
        <property type="entry name" value="plakophilin-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028435">
        <property type="entry name" value="Plakophilin/d_Catenin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372:SF1">
        <property type="entry name" value="PLAKOPHILIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10372">
        <property type="entry name" value="PLAKOPHILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0488">Methylation</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="ARM" evidence="18">
        <location>
            <begin position="358"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="794" mass="86968" checksum="589F3EF6C0D68B04" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VF50</accession>
    <name>A0A8C5VF50_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HAUS augmin like complex subunit 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HAUS1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022152">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VF50"/>
    <dbReference type="Ensembl" id="ENSMICT00000045869.2">
        <property type="protein sequence ID" value="ENSMICP00000018507.1"/>
        <property type="gene ID" value="ENSMICG00000017501.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885408"/>
    <dbReference type="GeneTree" id="ENSGT00390000006029"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070652">
        <property type="term" value="C:HAUS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026243">
        <property type="entry name" value="HAUS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31570:SF1">
        <property type="entry name" value="HAUS AUGMIN-LIKE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25762">
        <property type="entry name" value="HAUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02087">
        <property type="entry name" value="HAUSAUGMINL1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="135"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="259" mass="29638" checksum="BE7B64AF71DC5D4B" modified="2022-01-19" version="1">MRITIPQYEVNPRTTEILYHLSERNRVRDRDVHLVIEDLKQKASEYESEAKHLQDLLMESVNFSPANLSSTGSRYLNALVDSAVALETKDTSLTSFIPAVNDLTSDLFRTKSKNEEIKLELGKVEKNLTATLVLEKCLREDLKKAELHLSTLRAKVDHRLQNMDFLKAKSEEFRFQIKAAEEQLSARGMDASLSHQSLVALSEKLAELKRQTIPLKRKLESYLDLMPNPSLAQVKIEEAKRELDSIEAELTKKVDMMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VH82</accession>
    <name>A0A8C5VH82_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OR51T1</name>
        <name evidence="13" type="synonym">LOC105883374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006467">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VH82"/>
    <dbReference type="Ensembl" id="ENSMICT00000044857.2">
        <property type="protein sequence ID" value="ENSMICP00000023081.2"/>
        <property type="gene ID" value="ENSMICG00000026388.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286908"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15222">
        <property type="entry name" value="7tmA_OR51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF6">
        <property type="entry name" value="OLFACTORY RECEPTOR 51T1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9 10" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="78"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023081.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="362" mass="41340" checksum="423E079A5B0E86D2" modified="2022-01-19" version="1">YTKNLNYFIFLLFYPPSSSNILLLIFLFRVCPQPTMLIFNNTTSSSSNFLLTAFPGLERAHVWISIPVCCLYIIALLGNSMIFLITIIDQNLHKPMYYFLSMLSVVDLCLTITTLPTVLGVLWFHAQEISFKACLIQMFFLHAFSCLESSVLVAMAFDRFMAICNPLKYATVLTDMMVLVIVLVVCIRQVLFSSPVVVAIQTLSFYGGQELSHPFCYHPDVIKYTRSNSWFSSFCGMFLLFYMNATDLLFILFSYVLILRTVLNTVTPKQQQKALSTCVCHICAVTVFYMPMLSLSLAHRLFRSTPRVLCSTLANIYLLLPPVLNPIIYSLKTKTIRQAMFQLLRSKCSQGRHVRGLRGRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VII2</accession>
    <name>A0A8C5VII2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IQ motif containing F6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">IQCF6</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018251">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VII2"/>
    <dbReference type="Ensembl" id="ENSMICT00000046404.2">
        <property type="protein sequence ID" value="ENSMICP00000021088.2"/>
        <property type="gene ID" value="ENSMICG00000027112.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000004641"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039887">
        <property type="entry name" value="IQCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21633:SF15">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN F6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21633">
        <property type="entry name" value="IQ MOTIF CONTAINING F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5046767490" evidence="1">
        <location>
            <begin position="26"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021088.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="107" mass="13043" checksum="64331B905D3B552E" modified="2025-10-08" version="2">MVRRTLLHAALRAWVIQCWWRSMQAKMLEQRRRLALRLYTCQEWAVVKVQAQVRMWQARRRFLQARQAACVIQSHWRWHASQTRGLIRGRYEVRASRLELDIEILMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VIL4</accession>
    <name>A0A8C5VIL4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03012846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VIL4"/>
    <dbReference type="Ensembl" id="ENSMICT00000044501.2">
        <property type="protein sequence ID" value="ENSMICP00000019193.2"/>
        <property type="gene ID" value="ENSMICG00000030853.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00860000135817"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019193.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="102" mass="11765" checksum="D4DBBA2B8531DA8E" modified="2022-01-19" version="1">HGVVCSALLKRNFEISINSNEGGKSYSMAYVWKGVKILLKEQQMTFLQYFFVKQTILCLEFGICVLVKHCKSELLPLYLSVYHPLVNSYKLLCDCFFLDCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMH5</accession>
    <name>A0A8C5VMH5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-crystallin B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Beta-B1 crystallin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CRYBB1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Crystallins are the dominant structural components of the vertebrate eye lens.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta/gamma-crystallin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024608">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619251.1">
        <property type="nucleotide sequence ID" value="XM_012763797.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMH5"/>
    <dbReference type="Ensembl" id="ENSMICT00000035566.2">
        <property type="protein sequence ID" value="ENSMICP00000024077.1"/>
        <property type="gene ID" value="ENSMICG00000027965.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105870882"/>
    <dbReference type="KEGG" id="mmur:105870882"/>
    <dbReference type="CTD" id="1414"/>
    <dbReference type="GeneTree" id="ENSGT00940000160516"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005212">
        <property type="term" value="F:structural constituent of eye lens"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002088">
        <property type="term" value="P:lens development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000005">
        <property type="entry name" value="Crystallin, beta B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.20.10:FF:000002">
        <property type="entry name" value="Crystallin, beta B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050252">
        <property type="entry name" value="Beta/Gamma-Crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001064">
        <property type="entry name" value="Beta/gamma_crystallin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818:SF12">
        <property type="entry name" value="BETA-CRYSTALLIN B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11818">
        <property type="entry name" value="BETA/GAMMA CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00030">
        <property type="entry name" value="Crystall"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01367">
        <property type="entry name" value="BGCRYSTALLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00247">
        <property type="entry name" value="XTALbg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50915">
        <property type="entry name" value="CRYSTALLIN_BETA_GAMMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0273">Eye lens protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="99"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Beta/gamma crystallin 'Greek key'" evidence="9">
        <location>
            <begin position="191"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="252" mass="27894" checksum="4B9F055D55764A05" modified="2022-01-19" version="1">MSQATKASASATAAVNPGSDAKGKGGPPTGAAPGAGSALPPASMPASSAKAGDLPPGSYRLVVFEQENFQGRRMEFSGECSNLGDRGFDRVRSLIVTSGPWVAFEQSSFRGEMFILEKGEFPRWDTWSSSYRSDRLMSFRPVKMDTQEHKISLFEGANFKGKTAEIQEDDVPSLWAHGLCDRVGSVKVASGTWVGYQYPGYRGYQYLLEPGDFRHWNEWGAFQPQMQSLRRLRDRQWHREGCFPVLATEPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VPC9</accession>
    <name>A0A8C5VPC9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">3'-phosphoadenosine 5'-phosphosulfate synthase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PAPSS2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; sulfate assimilation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019292">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618344.1">
        <property type="nucleotide sequence ID" value="XM_012762890.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VPC9"/>
    <dbReference type="Ensembl" id="ENSMICT00000051589.2">
        <property type="protein sequence ID" value="ENSMICP00000025121.1"/>
        <property type="gene ID" value="ENSMICG00000003328.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870309"/>
    <dbReference type="KEGG" id="mmur:105870309"/>
    <dbReference type="CTD" id="9060"/>
    <dbReference type="GeneTree" id="ENSGT00390000009613"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050428">
        <property type="term" value="P:3'-phosphoadenosine 5'-phosphosulfate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042445">
        <property type="term" value="P:hormone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000001">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000006">
        <property type="entry name" value="bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11055:SF16">
        <property type="entry name" value="BIFUNCTIONAL 3'-PHOSPHOADENOSINE 5'-PHOSPHOSULFATE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APS kinase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="12">
        <location>
            <begin position="217"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="11">
        <location>
            <begin position="389"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="620" mass="69771" checksum="DD67B58E33C34C81" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VSM8</accession>
    <name>A0A8C5VSM8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein kinase SIK3</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Salt-inducible kinase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Serine/threonine-protein kinase QSK</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SIK3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Binds to and is activated by YWHAZ when phosphorylated on Thr-221. Interacts with 14-3-3 proteins. Interacts with HDAC4; this interaction leads to HDAC4 retention in the cytoplasm. Interacts with DEPTOR, MLST8/GbetaL, RICTOR and RPTOR.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03007015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007016">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039196.2">
        <property type="protein sequence ID" value="ENSMICP00000025522.1"/>
        <property type="gene ID" value="ENSMICG00000002343.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157259"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060351">
        <property type="term" value="P:cartilage development involved in endochondral bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001958">
        <property type="term" value="P:endochondral ossification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035108">
        <property type="term" value="P:limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035264">
        <property type="term" value="P:multicellular organism growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14410">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000156">
        <property type="entry name" value="Serine/threonine-protein kinase SIK3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF42">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="8"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="22">
        <location>
            <begin position="286"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="717"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="883"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="983"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1084"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1249"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="745"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="922"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1312" mass="146391" checksum="9B94912EF41E41DF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VT31</accession>
    <name>A0A8C5VT31_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Kinesin family member 13A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KIF13A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000029187.2">
        <property type="protein sequence ID" value="ENSMICP00000029660.2"/>
        <property type="gene ID" value="ENSMICG00000013830.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157508"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045184">
        <property type="term" value="P:establishment of protein localization"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22729">
        <property type="entry name" value="FHA_KIF13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000002">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000010">
        <property type="entry name" value="Kinesin family member 13A"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FHA_dom"/>
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    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
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    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="5"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="633"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1559"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1689"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="364"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1093"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1734"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="102"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029660.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1745" mass="195863" checksum="910E641EE3976173" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZN3</accession>
    <name>A0A8C5VZN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Contactin-associated protein-like 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC105881341</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014067">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014068">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014069">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014070">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014071">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014072">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VZN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000046128.2">
        <property type="protein sequence ID" value="ENSMICP00000030342.2"/>
        <property type="gene ID" value="ENSMICG00000033419.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160228"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000026">
        <property type="entry name" value="contactin-associated protein-like 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040941">
        <property type="entry name" value="GGGWT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF36">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02210">
        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51406">
        <property type="entry name" value="FIBRINOGEN_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034682807" description="Contactin-associated protein-like 3" evidence="16">
        <location>
            <begin position="27"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1216"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="17">
        <location>
            <begin position="32"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="184"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="367"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="544"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="20">
        <location>
            <begin position="580"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="776"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="942"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="18">
        <location>
            <begin position="992"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1178"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="914"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030342.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1259" mass="137111" checksum="60BEB5220E24CFFD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W021</accession>
    <name>A0A8C5W021_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PPA1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03018938">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W021"/>
    <dbReference type="Ensembl" id="ENSMICT00000032919.2">
        <property type="protein sequence ID" value="ENSMICP00000033764.2"/>
        <property type="gene ID" value="ENSMICG00000029937.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017004"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000005">
        <property type="entry name" value="Pyrophosphatase (inorganic) 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033764.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="269" mass="30402" checksum="8CDF64EF1859C1B6" modified="2022-01-19" version="1">MSGFSSEERAAPFTLDYRVFLDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHNDKHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINADDPDAANYNDIHDVKRLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKDKDFTMDIIKSTHDHWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACTVPTDVDKWFHHQKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0Q6</accession>
    <name>A0A8C5W0Q6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">FERM domain containing 4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FRMD4A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W8M9</accession>
    <name>A0A8C5W8M9_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="8">2.7.11.1</ecNumber>
        </recommendedName>
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        <name evidence="12" type="primary">ULK1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Serine/threonine-protein kinase involved in autophagy in response to starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_020283028.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000037490.2"/>
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        <property type="component" value="Chromosome 21"/>
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        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:omegasome membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:phagophore assembly site membrane"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
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            <begin position="16"/>
            <end position="278"/>
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    <sequence length="1045" mass="111756" checksum="B374918D95A1FC00" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W8Q3</accession>
    <name>A0A8C5W8Q3_MICMU</name>
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        <submittedName>
            <fullName evidence="12">ETS transcription factor ERG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ERG</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ETS family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Transcription Factor, Ets-1"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF216">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR ERG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
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        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
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        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SAM/Pointed domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00345">
        <property type="entry name" value="ETS_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00346">
        <property type="entry name" value="ETS_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PNT" evidence="11">
        <location>
            <begin position="120"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="10">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="9">
        <location>
            <begin position="318"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="249"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037544.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="486" mass="54462" checksum="790A393A040518FC" modified="2022-01-19" version="1">MIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSGDYGQTSKMSPRVPQQDWLSPPPARVTIKMECNPSQVNGSRSSPDECGVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVDILLFQNIDGKELCKMTKDDFQRLTPSYNAEILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSNCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGITQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAANPYWNSPTGGIYPNTRLPAGHMPSHLGSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W9C0</accession>
    <name>A0A8C5W9C0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses. Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells.</text>
    </comment>
    <comment type="function">
        <text evidence="5">In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus. Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner. Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the prohibitin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W9C0"/>
    <dbReference type="Ensembl" id="ENSMICT00000046970.2">
        <property type="protein sequence ID" value="ENSMICP00000036644.2"/>
        <property type="gene ID" value="ENSMICG00000037415.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183070"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039529">
        <property type="term" value="P:RIG-I signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00045600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="258" mass="28138" checksum="F873DA95704B1200" modified="2022-01-19" version="1">VAAKVLESIGKFGLALAIAGGVVNSALYNVGAGHRAIIFDRFRGVPDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLCILFRPGASQLLRIFTSIGEDYDERLLPSITTEILESVVACFDAGELITQRELVSRQVSDDLTLERAATFGLILDDMSLMHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAGDSKAAELITNSLATSGDGLIELCKLEATEDIAYQLIPAQSVLLQLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAB4</accession>
    <name>A0A8C5WAB4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytokine dependent hematopoietic cell linker</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CLNK</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005445">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593045.1">
        <property type="nucleotide sequence ID" value="XM_012737591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WAB4"/>
    <dbReference type="Ensembl" id="ENSMICT00000053032.2">
        <property type="protein sequence ID" value="ENSMICP00000035957.2"/>
        <property type="gene ID" value="ENSMICG00000005288.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105856099"/>
    <dbReference type="CTD" id="116449"/>
    <dbReference type="GeneTree" id="ENSGT00940000161846"/>
    <dbReference type="OrthoDB" id="9945442at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007169">
        <property type="term" value="P:cell surface receptor protein tyrosine kinase signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="B-cell linker protein isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051751">
        <property type="entry name" value="Immunoreceptor_sig_adapters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098:SF2">
        <property type="entry name" value="CYTOKINE-DEPENDENT HEMATOPOIETIC CELL LINKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14098">
        <property type="entry name" value="SH2 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0727">SH2 domain</keyword>
    <feature type="domain" description="SH2" evidence="4">
        <location>
            <begin position="302"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035957.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="421" mass="48234" checksum="D37B922D8650E622" modified="2022-01-19" version="1">MNRQGNGRTTKEGSSDLKFQNFALPKNRSWPRLNSATGLYHRINEPLPDCERNFAAILDGTKGHSDDDDYEDPELQMVEAWQTIKILPARPIKESEYADTRYFKSVIDTPLPSEAKTSSPTGEQSWSMQMRLKEVDKPISKDIRSQHVKGDKYIKRNKTPLPPPRPPMSVLKKYQPLPLEPERSRSTFPQRGPRQISLKDLNEVLGAEKVLHHQIKPESSHLSQNKNTQEIPPAITSSSFVMKNPSVQNRDHKGSMQSCSPQRCRSPASYGPPENKPFCKNTNWRKPLPARSDEKDAQNSEWYIGEHSRQAAEAALMKENKDGTFLVRDCSTKSKAEPYVLVVFYGNKVYNVKIRFLERNQQFALGTGLRGDEKFDSVEDIIEHYKYFPIILIDGKDKTGNHREQCYLTRPLPLTRHFSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WAV5</accession>
    <name>A0A8C5WAV5_MICMU</name>
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        <submittedName>
            <fullName evidence="2">Chromosome 19 open reading frame 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C19orf84</name>
        <name evidence="2" type="synonym">C22H19orf84</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026408">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000027720.2">
        <property type="protein sequence ID" value="ENSMICP00000037277.1"/>
        <property type="gene ID" value="ENSMICG00000028408.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105882845"/>
    <dbReference type="GeneTree" id="ENSGT00660000097488"/>
    <dbReference type="OrthoDB" id="9450965at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141196">
        <property type="term" value="P:transposable element silencing by piRNA-mediated DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="C19orf84"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="183" mass="19220" checksum="8DC34B28AD0C1CF5" modified="2022-01-19" version="1">MEQLKDGAEPQRNNLSLPSPGAEPWPSAPTPALPASLLSAPDPAHLGLPESLASVTVPIRLDTLSCLLHSALLGAYTLQQSLPSCPCCPQACHTQPGTARRPPRGRGGWEGRPRPGWGQRQQRRGPGRAEQAESDWAGGPGAGPETPPRMPPTLPAQGGKKEARGGESPLGTPPAAEDWETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XAT6</accession>
    <name>A0A8C5XAT6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type lectin domain family 18 member A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC105875436</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XAT6"/>
    <dbReference type="Ensembl" id="ENSMICT00000000253.3">
        <property type="protein sequence ID" value="ENSMICP00000000230.2"/>
        <property type="gene ID" value="ENSMICG00000000254.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141128"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00037">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.33.10:FF:000014">
        <property type="entry name" value="C-type lectin domain family 18 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000037">
        <property type="entry name" value="C-type lectin domain family 18 member A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034967651" description="C-type lectin domain family 18 member A" evidence="7">
        <location>
            <begin position="27"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="224"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="9">
        <location>
            <begin position="302"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000230.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49079" checksum="567F71BF146333F0" modified="2022-01-19" version="1">MLWLEPSPGLGGLLPVLLALLGIARAEVWMPHPQEQAPVPGALSRKESFLLLSLHNRLRSRVHPPAANMQRMDWSESLARLAQARAALCGTPGPSPASALHVGWNEQLQPAGLASFAEVVSLWFAEGQRYSHAAAECAHNATCARYTQLVWATSSQLGCGRHLCSMGQAAVEAFVCAYSPGGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCRNHGHLNVSTCHCHCPPGYTGRYCQVRCSVQCVHGRFREEECSCVCDVGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYGAKLKCQRKGGLLAQIESQKVQDILAFYLGRLETTNEVTDSDFETRNFWIGLTYKTAKDSFRWTTGEHQAFTSFAFGQDGDSGLVWFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWDPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XB39</accession>
    <name>A0A8C5XB39_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Catenin alpha-2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Alpha N-catenin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC105859125</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell junction</location>
            <location evidence="5">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Axon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the vinculin/alpha-catenin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005209">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005213">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XB39"/>
    <dbReference type="Ensembl" id="ENSMICT00000001477.3">
        <property type="protein sequence ID" value="ENSMICP00000001348.2"/>
        <property type="gene ID" value="ENSMICG00000001476.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234543"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016342">
        <property type="term" value="C:catenin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045296">
        <property type="term" value="F:cadherin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000006">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000007">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000008">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.230:FF:000011">
        <property type="entry name" value="Catenin alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036723">
        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914:SF23">
        <property type="entry name" value="CATENIN ALPHA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-0965">Cell junction</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10" id="KW-0221">Differentiation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="913"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="913"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="928"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001348.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="953" mass="105439" checksum="AB12B6F499469B71" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XBS6</accession>
    <name>A0A8C5XBS6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cation channel sperm associated auxiliary subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CATSPERG</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026962">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XBS6"/>
    <dbReference type="Ensembl" id="ENSMICT00000004445.3">
        <property type="protein sequence ID" value="ENSMICP00000004050.3"/>
        <property type="gene ID" value="ENSMICG00000004443.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014139"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036128">
        <property type="term" value="C:CatSper complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097228">
        <property type="term" value="C:sperm principal piece"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028246">
        <property type="entry name" value="CATSPERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053871">
        <property type="entry name" value="CATSPERG_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053873">
        <property type="entry name" value="CATSPERG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053874">
        <property type="entry name" value="CATSPERG_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053872">
        <property type="entry name" value="CATSPERG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14327:SF1">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED AUXILIARY SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14327">
        <property type="entry name" value="CATION CHANNEL SPERM-ASSOCIATED PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15064">
        <property type="entry name" value="CATSPERG_beta-prop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22846">
        <property type="entry name" value="CATSPERG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22851">
        <property type="entry name" value="CATSPERG_Ig-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22840">
        <property type="entry name" value="CATSPERG_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG N-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG beta-propeller" evidence="3">
        <location>
            <begin position="207"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG Ig-like" evidence="6">
        <location>
            <begin position="752"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="CATSPERG C-terminal" evidence="5">
        <location>
            <begin position="903"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004050.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1152" mass="132649" checksum="D03A88A5579A40C9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XC71</accession>
    <name>A0A8C5XC71_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cyclosome subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ANAPC2</name>
        <name evidence="16" type="synonym">LOC105882248</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 drives presynaptic differentiation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. In the context of the APC/C complex, directly interacts with UBE2C and UBE2S. Interacts (via cullin domain) with ANAPC11 and with UBCH10. Interacts with NEUROD2. Interacts with FBXO43; the interaction is direct.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639919.1">
        <property type="nucleotide sequence ID" value="XM_012784465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XC71"/>
    <dbReference type="Ensembl" id="ENSMICT00000006069.3">
        <property type="protein sequence ID" value="ENSMICP00000005533.2"/>
        <property type="gene ID" value="ENSMICG00000006069.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882248"/>
    <dbReference type="CTD" id="29882"/>
    <dbReference type="GeneTree" id="ENSGT00390000016127"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000284">
        <property type="entry name" value="Anaphase-promoting complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000027">
        <property type="entry name" value="Anaphase-promoting complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000008">
        <property type="entry name" value="anaphase-promoting complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="15">
        <location>
            <begin position="502"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="450"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Jayaseelan J."/>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
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                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLM family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014174">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642715.1">
        <property type="nucleotide sequence ID" value="XM_012787261.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XF61"/>
    <dbReference type="Ensembl" id="ENSMICT00000017724.3">
        <property type="protein sequence ID" value="ENSMICP00000016138.2"/>
        <property type="gene ID" value="ENSMICG00000017724.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883814"/>
    <dbReference type="KEGG" id="mmur:105883814"/>
    <dbReference type="CTD" id="51280"/>
    <dbReference type="GeneTree" id="ENSGT00530000063675"/>
    <dbReference type="OrthoDB" id="9947543at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026139">
        <property type="entry name" value="GOLM1/CASC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896:SF8">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15896">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 2/GP73-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02084">
        <property type="entry name" value="GOLM1CASC4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="185"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="39"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="340"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016138.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="404" mass="45759" checksum="622BADA93CC32EE5" modified="2022-01-19" version="1">MMGLGNGRRSMKSPPLVLAALVACIIVLGFNYWIASSRSVDLQTRIVELEGRVRRAAAERGAVELKKNEFQGELEKQREQLDKIQSSHNFQLESVNKLYQDEKAVLVNNITTGERLIRVLQDQLKTLQRNYGRLQQDVLQFQKNQTNLERKFSYDLSQCINQMKEVKEQCEERIEEVTKKGNEAVVSRDLSEKKDPSQQLQTLSKPQPRLQGAGLLQAEVPQREGNTPSDGESQMPTPSSKVALELKSRGKKEETNEIQFVSEKEPQRDSLGLPQEPGQEQAVEDRPVGGRDLGRARELSRTPQVPAALLLSQENQETEDPERDQLVIPDGQEEEQDAAEEGRNEQKLGGDDDYNMDENEAESETDKQAALAGNDKNLNVFIAEDQKRDAINLFDQREKRNHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XN24</accession>
    <name>A0A8C5XN24_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coordinator of PRMT5 and differentiation stimulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">COPRS</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019931">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594264.1">
        <property type="nucleotide sequence ID" value="XM_012738810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XN24"/>
    <dbReference type="Ensembl" id="ENSMICT00000053175.2">
        <property type="protein sequence ID" value="ENSMICP00000038016.1"/>
        <property type="gene ID" value="ENSMICG00000029453.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856850"/>
    <dbReference type="KEGG" id="mmur:105856850"/>
    <dbReference type="CTD" id="55352"/>
    <dbReference type="GeneTree" id="ENSGT00390000007384"/>
    <dbReference type="OrthoDB" id="9451728at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029289">
        <property type="entry name" value="COPR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36461">
        <property type="entry name" value="COORDINATOR OF PRMT5 AND DIFFERENTIATION STIMULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36461:SF1">
        <property type="entry name" value="COORDINATOR OF PRMT5 AND DIFFERENTIATION STIMULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15340">
        <property type="entry name" value="COPR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="184" mass="19855" checksum="C902A3BF13FBF4BA" modified="2022-01-19" version="1">MDPQAAGAQALGGAEPPRGPPLPSARETPPSPEAGFATADHSSHERENEKATDRLASGAQSIPNDSPPRGEGTQSEEEGFAVDDEGSDGEPNTWELSEGTQCPPKEQTGDLFNEDWDLELKADQGNPYDADDIQGSISQEVKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNC5</accession>
    <name>A0A8C5XNC5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PSMA3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. Interacts with AURKB. Interacts with CDKN1A. Interacts with MDM2 and RB1. Interacts with the C-terminus of TBXA2R isoform 2. Interacts with DNAJB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641086.1">
        <property type="nucleotide sequence ID" value="XM_012785632.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNC5"/>
    <dbReference type="Ensembl" id="ENSMICT00000040615.2">
        <property type="protein sequence ID" value="ENSMICP00000038209.1"/>
        <property type="gene ID" value="ENSMICG00000011559.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882907"/>
    <dbReference type="KEGG" id="mmur:105882907"/>
    <dbReference type="CTD" id="5684"/>
    <dbReference type="GeneTree" id="ENSGT00550000074912"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000077">
        <property type="entry name" value="Proteasome subunit alpha type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 7 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="9">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="255" mass="28465" checksum="FB6D59A3B0651FA7" modified="2022-01-19" version="1">MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSMNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQB3</accession>
    <name>A0A8C5XQB3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LOC105868014</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the immunoglobulin superfamily. CEA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQB3"/>
    <dbReference type="Ensembl" id="ENSMICT00000027148.2">
        <property type="protein sequence ID" value="ENSMICP00000039296.2"/>
        <property type="gene ID" value="ENSMICG00000036846.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01100000263479"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990782">
        <property type="term" value="F:protein tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20948">
        <property type="entry name" value="IgC2_CEACAM5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05740">
        <property type="entry name" value="IgI_hCEACAM_2_4_6_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05774">
        <property type="entry name" value="IgV_CEACAM_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000340">
        <property type="entry name" value="Carcinoembryonic antigen-related cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000517">
        <property type="entry name" value="Carcinoembryonic antigen-related cell adhesion molecule 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000244">
        <property type="entry name" value="carcinoembryonic antigen-related cell adhesion molecule 16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050831">
        <property type="entry name" value="CEA_cell_adhesion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427:SF1">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44427">
        <property type="entry name" value="CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13895">
        <property type="entry name" value="Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13927">
        <property type="entry name" value="Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034439144" description="Ig-like domain-containing protein" evidence="7">
        <location>
            <begin position="35"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="240"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="325"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039296.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="442" mass="48692" checksum="41A20F84D8E55764" modified="2022-01-19" version="1">MEPLSASPRRGCIPWQRLLLTVSLLTFWNTPAAAQLSVESMPLNAVEGKHVLLLIHNVLQDPYGYSWYKGDRVDSSYRIVSYVTVSQTITTGPAYSGRETIYPNGSLLFQNVTLNDIGYYTLQVIYANLQNEEVTALLRVYPELPKPSITSNSSSPVEDEDSVALTCEPETQDTTYLWWKDGQRLQGSDRLVMSLDNRTLILIFITRNDTGPYHCENWNPVSGSRSDPVNLNVLYGPDDPTISPPDSYYRQGANLNLTCHAASNPPAQYSWLINGSLQIPTQELFVPNITVNNSGSYACVAHNSATGRNRTTVKNITVSEPVAQPSIHASSSTVMEDKDSVVLTCRTNDTGISIRWIFNNQSLQVTERMQLTQGNISLSINPVKRGDAGEYQCEVSNPVSHYRSDIFRLTVEHGSSHGNSLGLSAGATVGIVIGVLARVALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XSY4</accession>
    <name>A0A8C5XSY4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox protein Hox-D1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXD1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Antp homeobox family. Labial subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608885.1">
        <property type="nucleotide sequence ID" value="XM_012753431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSY4"/>
    <dbReference type="Ensembl" id="ENSMICT00000058898.1">
        <property type="protein sequence ID" value="ENSMICP00000040929.1"/>
        <property type="gene ID" value="ENSMICG00000044650.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105865078"/>
    <dbReference type="KEGG" id="mmur:105865078"/>
    <dbReference type="CTD" id="3231"/>
    <dbReference type="GeneTree" id="ENSGT00940000161892"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019233">
        <property type="term" value="P:sensory perception of pain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000113">
        <property type="entry name" value="homeobox protein Hox-B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046327">
        <property type="entry name" value="HXA1/B1/D1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946:SF1">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45946">
        <property type="entry name" value="HOMEOBOX PROTEIN ROUGH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="227"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="229"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="303"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="328" mass="33852" checksum="175734E0376223AC" modified="2022-01-19" version="1">MSSYLEYVSCGGSGGGVSSEVLSFAPKFCRADARPVALQPAFPLGSGDGAFVSCLPLAAARPAPAPPAAPAQPPAPPAAAPRYSPCTLEGAYEPGAAPAAAAAGGADFGFLGSGPAYDFSGALGRAADDGHVHYATSAVFSGGGSFLLSGQVDYAAFGEPGPFPACLKEPADGHPGAFQTASPAPGAYPKSVSPASGFPAAFSTFEWMKVKRNAPKKSKFADYGAASPSSAIRTNFSTKQLTELEKEFHFNKYLTRARRIEIANCLQLNDTQVKIWFQNRRMKQKKREREGLLATAASVASLQLPLSGTSPTKSGKNPGSPSQAQEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XT60</accession>
    <name>A0A8C5XT60_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SLIT-ROBO Rho GTPase-activating protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rho GTPase-activating protein 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SRGAP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009746">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XT60"/>
    <dbReference type="Ensembl" id="ENSMICT00000058165.1">
        <property type="protein sequence ID" value="ENSMICP00000041138.1"/>
        <property type="gene ID" value="ENSMICG00000008203.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182824"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04383">
        <property type="entry name" value="RhoGAP_srGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11955">
        <property type="entry name" value="SH3_srGAP1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000010">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000006">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000005">
        <property type="entry name" value="SLIT-ROBO Rho GTPase-activating protein 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051627">
        <property type="entry name" value="SLIT-ROBO_RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035648">
        <property type="entry name" value="srGAP1/2/3_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14166">
        <property type="entry name" value="SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="14">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="13">
        <location>
            <begin position="441"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="12">
        <location>
            <begin position="680"/>
            <end position="739"/>
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            <end position="339"/>
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            <end position="759"/>
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            <end position="868"/>
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        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00073473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083891"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50002"/>
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        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
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        <name evidence="8" type="primary">COG5</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000004586"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
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    </evidence>
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            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF20649"/>
        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="860" mass="94746" checksum="8C5F381CB445439A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVQ1</accession>
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        <submittedName>
            <fullName evidence="10">RAB3A interacting protein</fullName>
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        <name evidence="10" type="primary">RAB3IP</name>
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        <name type="scientific">Microcebus murinus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
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                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEC2 family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012788730.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644185.1">
        <property type="nucleotide sequence ID" value="XM_012788731.3"/>
    </dbReference>
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        <property type="gene ID" value="ENSMICG00000004622.3"/>
    </dbReference>
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        <property type="gene ID" value="ENSMICG00000004622.3"/>
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        <property type="gene ID" value="ENSMICG00000004622.3"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005654">
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.4880:FF:000001">
        <property type="entry name" value="Guanine nucleotide exchange factor for Rab-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF2">
        <property type="entry name" value="RAB-3A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="9">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="151"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="460" mass="51057" checksum="482DA88DA5BF1634" modified="2022-01-19" version="1">MANDPLEGFHEVNLASPTSPDLLGVCDSGTQEQTTSPSVIYRPHPSALCSTPIQANALDVSELPTQPVYSSPRRLNCAEISGISIHVTDPAPCSTSGVTAGLTKLTTRKDNCNAEREFLQGATVTEACDGSDDIFGLSTDSLSRLRSPSVLEVREKGYERLKEELAKAQRELKLKDEECERLSKVRDQLGQELEELTASLFEEAHKMVREANVKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPMQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLNVIQPIVKDSKEADLSLYNEFRSWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLRKEMSLAKLGYFKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXN7</accession>
    <name>A0A8C5XXN7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HEAT repeat-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HEATR5B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011874">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011876">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000061620.1">
        <property type="protein sequence ID" value="ENSMICP00000042845.1"/>
        <property type="gene ID" value="ENSMICG00000003296.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006205"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000098">
        <property type="entry name" value="HEAT repeat-containing protein 5A isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000262">
        <property type="entry name" value="HEAT repeat-containing protein 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF2">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1326"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1334"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2193" mass="237377" checksum="D2B663AB9A0FF292" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYD1</accession>
    <name>A0A8C5XYD1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sodium-dependent phosphate transport protein 2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Na(+)-dependent phosphate cotransporter 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Sodium/phosphate cotransporter 2B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Solute carrier family 34 member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC34A2</name>
        <name evidence="22" type="synonym">LOC105856163</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in actively transporting phosphate into cells via Na(+) cotransport.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:71255"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71256"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC34A transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005497">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005498">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYD1"/>
    <dbReference type="Ensembl" id="ENSMICT00000069916.1">
        <property type="protein sequence ID" value="ENSMICP00000042979.1"/>
        <property type="gene ID" value="ENSMICG00000045359.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183177"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Sexton D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <text evidence="11">Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.</text>
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        <text evidence="2 12">Belongs to the IL-7/IL-9 family.</text>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001942-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="177" mass="20357" checksum="3E073B32A4442E0E" modified="2022-01-19" version="1">MFHVSFRYIFGIPPLILVLLPVASSDCDIEGQDGKEYESVLMISIDELLDSMKEIGSNCLNNESNFFKKHLCDDNKEGTFLYRAARKLKQFRKMNNSDNFDHHLSMVSQGTLQLLNCTSKVKGRKSPSLSEAQPTKNLEENKSLKEQKKQNGLCFLKRLIQKIKTCWNKILRGTKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYT7</accession>
    <name>A0A8C5XYT7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydroxysteroid 17-beta dehydrogenase 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">HSD17B14</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYT7"/>
    <dbReference type="Ensembl" id="ENSMICT00000070078.1">
        <property type="protein sequence ID" value="ENSMICP00000043307.1"/>
        <property type="gene ID" value="ENSMICG00000046832.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161346"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004303">
        <property type="term" value="F:estradiol 17-beta-dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006706">
        <property type="term" value="P:steroid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="107" mass="11148" checksum="2DC0F33FE5FE1468" modified="2022-01-19" version="1">MTKALALDESQYGVRVNCISPGNIWTPLWEELAASTPDPRATVLEGTLAQPMGRMGQPAEVGAAAVFLASGATFCTGMDLFLTGGAELGYGRKASPGTPVDIPPSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYY0</accession>
    <name>A0A8C5XYY0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">T cell receptor alpha variable 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TRAV21</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004402">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYY0"/>
    <dbReference type="Ensembl" id="ENSMICT00000059887.1">
        <property type="protein sequence ID" value="ENSMICP00000043149.1"/>
        <property type="gene ID" value="ENSMICG00000042869.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163708"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042101">
        <property type="term" value="C:T cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051006">
        <property type="entry name" value="TCR_variable_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19343:SF13">
        <property type="entry name" value="T CELL RECEPTOR ALPHA VARIABLE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-1279">T cell receptor</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="96" mass="10529" checksum="401F9ADD9D60CB8A" modified="2022-01-19" version="1">KQEVMQTPETLSVPEGESLALNCSFTDSAIYFLQWFRQDSGKGLTSLLLIQSNQREQTSGRFKASLDKSSRQSTLNIAASQPGDSATYLCAVKHNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZQ5</accession>
    <name>A0A8C5XZQ5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CD19 molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CD19</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
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                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
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                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
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                <person name="Kovar C."/>
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                <person name="Lee S."/>
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                <person name="Mathew T."/>
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                <person name="Nguyen L."/>
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                <person name="Quiroz J."/>
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                <person name="Campbell C."/>
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                <person name="Shamim M."/>
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                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L36a-like</fullName>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Wang M."/>
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                <person name="Blankenburg K."/>
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                <person name="Nguyen L."/>
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                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
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                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020005">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628095.1">
        <property type="nucleotide sequence ID" value="XM_012772641.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZT8"/>
    <dbReference type="Ensembl" id="ENSMICT00000066247.1">
        <property type="protein sequence ID" value="ENSMICP00000043770.1"/>
        <property type="gene ID" value="ENSMICG00000047597.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105875527"/>
    <dbReference type="KEGG" id="mmur:105875527"/>
    <dbReference type="GeneTree" id="ENSGT00390000018085"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12425" checksum="C55EA34A30C06C88" modified="2022-01-19" version="1">MVNVPKTRRTSCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNYRSKRMLAIKRSKHFELGGDKKRKGQVIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1D0</accession>
    <name>A0A8C5Y1D0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOCKER domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC105872876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y1D0"/>
    <dbReference type="Ensembl" id="ENSMICT00000058577.1">
        <property type="protein sequence ID" value="ENSMICP00000044679.1"/>
        <property type="gene ID" value="ENSMICG00000045663.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154903"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11706">
        <property type="entry name" value="DHR2_DOCK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026799">
        <property type="entry name" value="DHR2_DOCK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF6">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHR-2_Lobe_B"/>
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    </dbReference>
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        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_DOCK"/>
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    </dbReference>
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        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="84"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="525"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="703" mass="81047" checksum="C91C49A7468D5681" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1J6</accession>
    <name>A0A8C5Y1J6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S15a</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the small ribosomal subunit. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Required for proper erythropoiesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000044466.1"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="C:ribosome"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
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    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
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        <property type="entry name" value="Ribosomal_uS8_sf"/>
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        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
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        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RIBOSOMAL_S8"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="130" mass="14844" checksum="4E5C80A830D8EB19" modified="2022-01-19" version="1">MVRMNVLANALKSINNAEKRGKRQVLIQPCSKVIVRFLTVMMKHGYIGKFEIIDDHRAGEIVVNLTGRLNKCGVISPRFDVQLKDLEKWQNNLFPSRQFGFIVLTTSAGIMDHEEARRKHTGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y6Y4</accession>
    <name>A0A8C5Y6Y4_MICMU</name>
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        <submittedName>
            <fullName evidence="2">PLAC8 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PLAC8L1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cornifelin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022535">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03022536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03022537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629621.1">
        <property type="nucleotide sequence ID" value="XM_012774167.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y6Y4"/>
    <dbReference type="Ensembl" id="ENSMICT00000058987.1">
        <property type="protein sequence ID" value="ENSMICP00000046724.1"/>
        <property type="gene ID" value="ENSMICG00000041566.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105876488"/>
    <dbReference type="KEGG" id="mmur:105876488"/>
    <dbReference type="CTD" id="153770"/>
    <dbReference type="GeneTree" id="ENSGT00940000160864"/>
    <dbReference type="OMA" id="FCWPLLP"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="178" mass="19955" checksum="4130B4DF4B65CAF0" modified="2022-01-19" version="1">MNWFGSYFSKCPQDVSLINIHSPLLSLVSSEDQQHFISKLRSHGPARVVVKQPVRGASSRTTITAVVQTGGDWSTGLFSVCRDKRICFCGLCCPVCLECDIARHYGECLCWPLLPGSTFALRIGTRERHKIQGTLCEDWLAVHCCWPFSICQVARELKMRTSQLYEICAVPSTKDTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8N1</accession>
    <name>A0A8C5Y8N1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">BRG1-associated factor 57</fullName>
        </alternativeName>
    </protein>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03033915">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y8N1"/>
    <dbReference type="Ensembl" id="ENSMICT00000060465.1">
        <property type="protein sequence ID" value="ENSMICP00000047454.1"/>
        <property type="gene ID" value="ENSMICG00000045268.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003628"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016922">
        <property type="term" value="F:nuclear receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21983">
        <property type="entry name" value="HMG-box_SMARCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000011">
        <property type="entry name" value="Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232">
        <property type="entry name" value="SMARCE1 REGULATOR OF CHROMATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46232:SF1">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY E MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="12">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="222" mass="25519" checksum="B90DE950D9C8823B" modified="2022-01-19" version="1">MSKRPSYAPPPTPAPATQMPSTPGFVGYNPYSHLAYNNYRLGGNPGTNSRVTASSGITIPKPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQEYLNEYEAEKIEYNESMKAYHNCPAYLAYINAKSRAEAALEEESRQRQSRMEKGEPYMSIQPAEDPDDYDDGFSMKHTMGNVIRKKVISSLLFFKVFFLFFGILWGYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y9F9</accession>
    <name>A0A8C5Y9F9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor AP-2 epsilon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TFAP2E</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001646">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620700.1">
        <property type="nucleotide sequence ID" value="XM_012765246.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y9F9"/>
    <dbReference type="Ensembl" id="ENSMICT00000058848.1">
        <property type="protein sequence ID" value="ENSMICP00000048289.1"/>
        <property type="gene ID" value="ENSMICG00000046802.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105871756"/>
    <dbReference type="KEGG" id="mmur:105871756"/>
    <dbReference type="CTD" id="339488"/>
    <dbReference type="GeneTree" id="ENSGT00950000182848"/>
    <dbReference type="OrthoDB" id="6252992at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004979">
        <property type="entry name" value="TF_AP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013854">
        <property type="entry name" value="TF_AP2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10812:SF13">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-2-EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03299">
        <property type="entry name" value="TF_AP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01748">
        <property type="entry name" value="AP2TNSCPFCT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor AP-2 C-terminal" evidence="7">
        <location>
            <begin position="219"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="443" mass="46139" checksum="B01BC39104C6D6E0" modified="2022-01-19" version="1">MLVHAYSAMERPDGLGAAAGGARLSSLPQAAYGPAAPLCHTPAAAAAAADFQPPYFPPPYPQPPLPYGQAPDAAAAFPHLAGDPYGGLAPLAQPQPPQAAWAAPRAAARTHDEPPSLLAPPARALGLDPRRDYAAAVPRLLHGLADGAHGLADGPLGLPGLAAPPGLEDLQAMDEPGMSLLDQSVIKKVPVPSKGSSLSALVVAKDSLVGGITNPGEVFCSVPGRLSLLSSTSKYKVTVGEVQRRLSPPECLNASLLGGVLRRAKSKNGGRCLRERLEKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAAAEYLCRQHADPGELHSRKSMLLAAKQICKEFADLMAQDRSPLGNSRPALILEPGVQSCLTHFSLITHGFGGPAICAALTAFQNYLLESLKGLDKMFLSSAGSGHGDTKASEKDAKHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEL5</accession>
    <name>A0A8C5YEL5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="24">STEAP3 metalloreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">STEAP3</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71771"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:71773"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:71767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:71769"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the STEAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604683.1">
        <property type="nucleotide sequence ID" value="XM_012749229.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEL5"/>
    <dbReference type="Ensembl" id="ENSMICT00000058172.1">
        <property type="protein sequence ID" value="ENSMICP00000049584.1"/>
        <property type="gene ID" value="ENSMICG00000000288.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105862720"/>
    <dbReference type="GeneTree" id="ENSGT00390000008042"/>
    <dbReference type="OrthoDB" id="550646at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008823">
        <property type="term" value="F:cupric reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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            <begin position="29"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEV1</accession>
    <name>A0A8C5YEV1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-type lectin domain containing 16A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CLEC16A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CLEC16A/gop-1 family.</text>
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    <dbReference type="EMBL" id="ABDC03020904">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012784845.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000049451.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000013826"/>
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        <property type="component" value="Chromosome 17"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:endosomal transport"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of autophagosome maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of TORC1 signaling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:vacuolar transport"/>
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        <property type="entry name" value="CLEC16A/TT9"/>
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        <property type="entry name" value="CLEC16A/TT9_C"/>
    </dbReference>
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        <property type="entry name" value="CLEC16A/TT9_N"/>
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    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19439">
        <property type="entry name" value="CLEC16A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="4">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CLEC16A/TT9 C-terminal" evidence="5">
        <location>
            <begin position="245"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="892"/>
            <end position="948"/>
        </location>
    </feature>
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        <location>
            <begin position="1024"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="892"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00006441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1050" mass="117290" checksum="555B7F8042025610" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFS9</accession>
    <name>A0A8C5YFS9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 53 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM53B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM53 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019532">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFS9"/>
    <dbReference type="Ensembl" id="ENSMICT00000003906.3">
        <property type="protein sequence ID" value="ENSMICP00000003563.1"/>
        <property type="gene ID" value="ENSMICG00000003907.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000030817.2">
        <property type="protein sequence ID" value="ENSMICP00000019975.1"/>
        <property type="gene ID" value="ENSMICG00000003907.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069686.1">
        <property type="protein sequence ID" value="ENSMICP00000050325.1"/>
        <property type="gene ID" value="ENSMICG00000003907.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063371"/>
    <dbReference type="OMA" id="WSPDPNP"/>
    <dbReference type="OrthoDB" id="9934966at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029356">
        <property type="entry name" value="FAM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28567">
        <property type="entry name" value="PROTEIN FAM53A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28567:SF1">
        <property type="entry name" value="PROTEIN FAM53B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15242">
        <property type="entry name" value="FAM53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="424" mass="45997" checksum="67CF66C4507B39C1" modified="2022-01-19" version="1">MVMVLSKSLSNQGADSIACRNFKPELHTPKKMSQGPTLFSCGIMENDRWRDLDRKCPLQIDQPSASIWECLPEKCQDGSLWHRDAVTACAVTSLIKDLSINDHNGNPSAPPSKRQCRSLSFSDEMSSCRTSWRPLGSKVWTPVEKRRCYSGGSVQRYSNGVGTMQRSSSFSLPSRASVLSSPCDQAAFHHRFGGQPCQGVLGSAPCGQVGDTWSPDPHPVGGGRLDLQRSLSCSHDQFSFTEYCPPSANSTPASTPELVRRSSGLARSRSQPCVLNDKKVGVKRRRPEEVQEQRPSLDLAKMAQNCQTFSSLSCLSAGMEDCGPQSPFALHASSTRAWTTLLSASGPGGRTPAGTPVPEPLPHSFDDQLTCQEDLSCEESDGCALDEDCSRRGELATAWRDHGAAGNSLCSLDGELDIEQIENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHP0</accession>
    <name>A0A8C5YHP0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MAP6 domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MAP6D1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STOP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592393.1">
        <property type="nucleotide sequence ID" value="XM_012736939.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHP0"/>
    <dbReference type="Ensembl" id="ENSMICT00000072780.1">
        <property type="protein sequence ID" value="ENSMICP00000050986.1"/>
        <property type="gene ID" value="ENSMICG00000049143.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105855782"/>
    <dbReference type="KEGG" id="mmur:105855782"/>
    <dbReference type="CTD" id="79929"/>
    <dbReference type="GeneTree" id="ENSGT00530000063947"/>
    <dbReference type="OrthoDB" id="9632339at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005798">
        <property type="term" value="C:Golgi-associated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007882">
        <property type="entry name" value="MAP6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14759:SF37">
        <property type="entry name" value="MAP6 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14759">
        <property type="entry name" value="STOP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="192" mass="20400" checksum="C6EFBAA04DD19F98" modified="2022-01-19" version="1">MAWPCISRLCCLARRWNQLDRSDVAVPLTLHGYSDLENEEPGPGGAASRRGQSPAGDRAPGRDVPLTQYQRDFGVWTAPAGPRDAPQGRGPGAGGRRGKPSAPPGRGVYVLPVGDADAAAAATTSYRQEFQAWTAVKPSRSTKAKPARVITTHTSGWDSSPGASFQVPEVRKKFTPNPSAIFQASAPRILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EIR7</accession>
    <name>A0A8C6EIR7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein phosphatase 1 regulatory subunit 27</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dysferlin-interacting protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PPP1R27</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with DYSF and PPP1CA.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019697">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644888.1">
        <property type="nucleotide sequence ID" value="XM_012789434.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EIR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000062347.1">
        <property type="protein sequence ID" value="ENSMICP00000045470.1"/>
        <property type="gene ID" value="ENSMICG00000044822.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105884954"/>
    <dbReference type="CTD" id="116729"/>
    <dbReference type="GeneTree" id="ENSGT00940000159603"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019902">
        <property type="term" value="F:phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000189">
        <property type="entry name" value="Protein phosphatase 1 regulatory subunit 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053080">
        <property type="entry name" value="PP1_regulatory_subunit_27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46899:SF3">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00064655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00070068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="154" mass="17426" checksum="9F2F5F398E5DFDDF" modified="2022-01-19" version="1">MPSRTVRYARYSPRQRRRRLLADRSVRFPNDVLFLDHIRQGDLEQVGRFLRARKVSLATIHPSGLAALHEAVLSGNLDCVKLLVKYGADIHQRDEVGWTPLHIACSDGYPDIARYLISLGADRDAANNDGDLPSDLIDPDFKDLVELFKGTRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ECA1</accession>
    <name>A0A8B7ECA1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GTF2H4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Part of TBP-based Pol II pre-initiation complex (PIC), in which Pol II core assembles with general transcription factors and other specific initiation factors including GTF2E1, GTF2E2, GTF2F1, GTF2F2, TCEA1, ERCC2, ERCC3, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2A1, GTF2A2, GTF2B and TBP; this large multi-subunit PIC complex mediates DNA unwinding and targets Pol II core to the transcription start site where the first phosphodiester bond forms.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591834.1">
        <property type="nucleotide sequence ID" value="XM_012736380.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ECA1"/>
    <dbReference type="Ensembl" id="ENSMICT00000061427.1">
        <property type="protein sequence ID" value="ENSMICP00000044260.1"/>
        <property type="gene ID" value="ENSMICG00000047381.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105855409"/>
    <dbReference type="CTD" id="2968"/>
    <dbReference type="GeneTree" id="ENSGT00390000014159"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000438">
        <property type="term" value="C:core TFIIH complex portion of holo TFIIH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2610:FF:000001">
        <property type="entry name" value="General transcription factor IIH subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="12">
        <location>
            <begin position="390"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="463" mass="52255" checksum="55CE795D0A47D3E3" modified="2022-01-19" version="1">MESTPSRGGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPVFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EGN7</accession>
    <name>A0A8B7EGN7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyglutamine-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyglutamine tract-binding protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PQBP1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Interacts with POU3F2/Brn-2, ATXN1, TXNL4A, HTT and AR. Interaction with ATXN1 correlates positively with the length of the polyglutamine tract. Interacts with RNA polymerase II large subunit in a phosphorylation-dependent manner. Forms a ternary complex with ATXN1 mutant and phosphorylated RNA polymerase II. Interacts (via C-terminus) with TXNL4A and CD2BP2. Interacts (via WW domain) with ATN1 and SF3B1, and may interact with additional splice factors. Interacts (via WW domain) with WBP11; Leading to reduce interaction between PQBP1 and TXNL4A. Interacts with CAPRIN1. Interacts with DDX1. Interacts with SFPQ. Interacts with KHSRP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03036554">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593537.1">
        <property type="nucleotide sequence ID" value="XM_012738083.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593539.1">
        <property type="nucleotide sequence ID" value="XM_012738085.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593540.1">
        <property type="nucleotide sequence ID" value="XM_012738086.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EGN7"/>
    <dbReference type="Ensembl" id="ENSMICT00000061926.1">
        <property type="protein sequence ID" value="ENSMICP00000044786.1"/>
        <property type="gene ID" value="ENSMICG00000005973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856387"/>
    <dbReference type="KEGG" id="mmur:105856387"/>
    <dbReference type="CTD" id="10084"/>
    <dbReference type="GeneTree" id="ENSGT00950000183102"/>
    <dbReference type="OMA" id="IYHECSK"/>
    <dbReference type="OrthoDB" id="42462at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071598">
        <property type="term" value="C:neuronal ribonucleoprotein granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002218">
        <property type="term" value="P:activation of innate immune response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071360">
        <property type="term" value="P:cellular response to exogenous dsRNA"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002230">
        <property type="term" value="P:positive regulation of defense response to virus by host"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000140">
        <property type="entry name" value="polyglutamine-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF3">
        <property type="entry name" value="POLYGLUTAMINE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="5" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="86"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="99"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="258" mass="29692" checksum="1E64C4563D686879" modified="2022-01-19" version="1">MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLEGLPPSWYKVFDPSCGLPYYWNVDTDLVSWLSPHDPNFVVTKSAKKLRSSNADAEEKSDRSHDKSDRGHDKSDRGHEKPDRGHDKSDRDRERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKVASRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EIN0</accession>
    <name>A0A8B7EIN0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sodium/potassium-transporting ATPase subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ATP1B4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="8">This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus inner membrane</location>
            <topology evidence="7">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the X(+)/potassium ATPases subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034474">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594504.1">
        <property type="nucleotide sequence ID" value="XM_012739050.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EIN0"/>
    <dbReference type="Ensembl" id="ENSMICT00000051427.2">
        <property type="protein sequence ID" value="ENSMICP00000037359.1"/>
        <property type="gene ID" value="ENSMICG00000029966.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105856969"/>
    <dbReference type="KEGG" id="mmur:105856969"/>
    <dbReference type="CTD" id="23439"/>
    <dbReference type="GeneTree" id="ENSGT01030000234579"/>
    <dbReference type="OrthoDB" id="5912413at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005890">
        <property type="term" value="C:sodium:potassium-exchanging ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1660:FF:000001">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1660">
        <property type="entry name" value="Na, k-atpase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000402">
        <property type="entry name" value="Na/K_ATPase_sub_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038702">
        <property type="entry name" value="Na/K_ATPase_sub_beta_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01107">
        <property type="entry name" value="Na_K_ATPase_bet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523:SF12">
        <property type="entry name" value="PROTEIN ATP1B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11523">
        <property type="entry name" value="SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00287">
        <property type="entry name" value="Na_K-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00391">
        <property type="entry name" value="ATPASE_NA_K_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="357" mass="41699" checksum="A88CDFE2AA0199E6" modified="2022-01-19" version="1">MRRQLRSRRAPAFPYGYRYRLDDQDEVNQNYLADEEEEAEEEARVMVVPELEEEEEEKEKEEEEVEEKEEEEGQGQPTGNAWWRKLQILNEYLWDPERRMSLARTGQSWSLILVIYFFFYASLAAVITLCMYTLFLTISPYMPTFTERVKHPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQGYNDSLQEEMNVDCPPGQYFIQDGNEDEDKKACQFKRSFLKNCSGLEDPTFGYSTGQPCILLKMNRIVGFRPELGDPVKVSCKVQRGDENDIRSINYYPESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGIINDVINDRFVGRVIFTLNIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ENW9</accession>
    <name>A0A8B7ENW9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coiled-coil alpha-helical rod protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-helical coiled-coil rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CCHCR1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be a regulator of keratinocyte proliferation or differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007257">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596600.1">
        <property type="nucleotide sequence ID" value="XM_012741146.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ENW9"/>
    <dbReference type="Ensembl" id="ENSMICT00000069199.1">
        <property type="protein sequence ID" value="ENSMICP00000041492.1"/>
        <property type="gene ID" value="ENSMICG00000001488.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858175"/>
    <dbReference type="CTD" id="54535"/>
    <dbReference type="GeneTree" id="ENSGT00940000153251"/>
    <dbReference type="OrthoDB" id="193258at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009800">
        <property type="entry name" value="HCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46822:SF1">
        <property type="entry name" value="COILED-COIL ALPHA-HELICAL ROD PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07111">
        <property type="entry name" value="HCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="32"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="157"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="500"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="782" mass="88424" checksum="D7A2D74EF727D73A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQA0</accession>
    <name>A0A8B7EQA0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sad1 and UNC84 domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SUN2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus inner membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03008886">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597196.1">
        <property type="nucleotide sequence ID" value="XM_012741742.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQA0"/>
    <dbReference type="Ensembl" id="ENSMICT00000011820.3">
        <property type="protein sequence ID" value="ENSMICP00000010763.3"/>
        <property type="gene ID" value="ENSMICG00000011818.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858538"/>
    <dbReference type="KEGG" id="mmur:105858538"/>
    <dbReference type="CTD" id="25777"/>
    <dbReference type="GeneTree" id="ENSGT00940000160024"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140444">
        <property type="term" value="F:cytoskeleton-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005521">
        <property type="term" value="F:lamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090292">
        <property type="term" value="P:nuclear matrix anchoring at nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031022">
        <property type="term" value="P:nuclear migration along microfilament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021817">
        <property type="term" value="P:nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21438">
        <property type="entry name" value="SUN2_cc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000009">
        <property type="entry name" value="SUN domain-containing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040994">
        <property type="entry name" value="Sun_CC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF22">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18580">
        <property type="entry name" value="HTH_SUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="9">
        <location>
            <begin position="561"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="358"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010763.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="723" mass="80814" checksum="DC2A05FBF2A68BFD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ERD3</accession>
    <name>A0A8B7ERD3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytosolic arginine sensor for mTORC1 subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CASTOR2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GATS family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021104">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597649.1">
        <property type="nucleotide sequence ID" value="XM_012742195.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ERD3"/>
    <dbReference type="Ensembl" id="ENSMICT00000015319.3">
        <property type="protein sequence ID" value="ENSMICP00000013972.2"/>
        <property type="gene ID" value="ENSMICG00000015328.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858824"/>
    <dbReference type="KEGG" id="mmur:105858824"/>
    <dbReference type="CTD" id="729438"/>
    <dbReference type="GeneTree" id="ENSGT00390000006208"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000003">
        <property type="entry name" value="Cytosolic arginine sensor for mTORC1 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000004">
        <property type="entry name" value="Cytosolic arginine sensor for mTORC1 subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049479">
        <property type="entry name" value="CASTOR1_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040778">
        <property type="entry name" value="CASTOR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026249">
        <property type="entry name" value="CASTOR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF2">
        <property type="entry name" value="CYTOSOLIC ARGININE SENSOR FOR MTORC1 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21389">
        <property type="entry name" value="CASTOR1_ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18700">
        <property type="entry name" value="Castor1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02078">
        <property type="entry name" value="GATSLIKEFMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR1 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CASTOR ACT" evidence="4">
        <location>
            <begin position="73"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Cytosolic arginine sensor for mTORC1 subunit 1/2 ACT-like" evidence="6">
        <location>
            <begin position="177"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CASTOR ACT" evidence="4">
        <location>
            <begin position="261"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013972.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="329" mass="36005" checksum="B9D0E0E6BF173A57" modified="2022-01-19" version="1">MELHILEHRLQVASVAKESIPLFTYGLIKLAFLSSKTRCKFFSLTETPEDYTIIVDEEGFLELPSSEHLSVADATWLALNVVSGGGSFSSSQPIGVTKIAKSVIAPLADQNISVFMLSTYQTDFILVRERDLPFVTHTLSSEFTILRVVNGETVAAENLGITNGFVKPKMVQRPVIHPLSSPSNRFCVTSLDPDTLPAVATLLMDVMFYSTGVKDPMAAGDDCGHIRFFSFSLIEGYISLVMDVQTQQRFPSNLLFTSASGELWKMVRIGGQPLGFDECGIVAQISEPLAAADIPAYYISTFKFDHALVPEENISGVISALKVSQAEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ERM5</accession>
    <name>A0A8B7ERM5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.97</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Parahox neighbor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">URAD</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+) = (S)-allantoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:26301"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="4.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; urate degradation; (S)-allantoin from urate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the OHCU decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03017823">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017824">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597764.1">
        <property type="nucleotide sequence ID" value="XM_012742310.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ERM5"/>
    <dbReference type="Ensembl" id="ENSMICT00000037407.2">
        <property type="protein sequence ID" value="ENSMICP00000028505.1"/>
        <property type="gene ID" value="ENSMICG00000032881.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858902"/>
    <dbReference type="KEGG" id="mmur:105858902"/>
    <dbReference type="CTD" id="646625"/>
    <dbReference type="GeneTree" id="ENSGT00390000002395"/>
    <dbReference type="OrthoDB" id="9970124at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00652"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051997">
        <property type="term" value="F:2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000255">
        <property type="term" value="P:allantoin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006196">
        <property type="term" value="P:AMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046059">
        <property type="term" value="P:dAMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006157">
        <property type="term" value="P:deoxyadenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006161">
        <property type="term" value="P:deoxyguanosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006149">
        <property type="term" value="P:deoxyinosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046055">
        <property type="term" value="P:dGMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046038">
        <property type="term" value="P:GMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006147">
        <property type="term" value="P:guanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009114">
        <property type="term" value="P:hypoxanthine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006204">
        <property type="term" value="P:IMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006148">
        <property type="term" value="P:inosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009115">
        <property type="term" value="P:xanthine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3330.10:FF:000001">
        <property type="entry name" value="2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017580">
        <property type="entry name" value="OHCU_decarboxylase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03164">
        <property type="entry name" value="UHCUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43466:SF1">
        <property type="entry name" value="2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="13">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="173" mass="19146" checksum="CB489B8198872D98" modified="2022-01-19" version="1">MDIEKVNSMDFGEFVDVFGNVIERCPLIAAAVWSQRPFSDVEDLEKHFFAFIDALPQSGQEGILRCHPDLAGRELQRGTLTAESQREQSGAGLTSLGADERLQLAELNAQYRARFGFPFVLAARLSGRAAVPRELARRLHCPPAQELRTALGEVKKIGRLRLADLFGADPARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EV65</accession>
    <name>A0A8B7EV65_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Potassium channel tetramerization domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KCTD5</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020805">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599141.1">
        <property type="nucleotide sequence ID" value="XM_012743687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EV65"/>
    <dbReference type="Ensembl" id="ENSMICT00000051857.2">
        <property type="protein sequence ID" value="ENSMICP00000035819.1"/>
        <property type="gene ID" value="ENSMICG00000017136.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859678"/>
    <dbReference type="KEGG" id="mmur:105859678"/>
    <dbReference type="CTD" id="54442"/>
    <dbReference type="GeneTree" id="ENSGT00940000160374"/>
    <dbReference type="OMA" id="LPGKWVR"/>
    <dbReference type="OrthoDB" id="1244179at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031463">
        <property type="term" value="C:Cul3-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18390">
        <property type="entry name" value="BTB_POZ_KCTD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2000:FF:000001">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000005">
        <property type="entry name" value="Potassium channel tetramerization domain-containing 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958:SF12">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14958">
        <property type="entry name" value="POTASSIUM CHANNEL TETRAMERISATION DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="44"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="234" mass="26074" checksum="E82180C099FA8A2F" modified="2022-01-19" version="1">MAENHCELLPPAPSGLGAGLGGGLCRRCSAGLGALAQRPGSVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLCQADPDLDSDKDETGAYLIDRDPTYFGPVLNYLRHGKLVINKDLAEEGVLEEAEFYNITSLIKLVKDKIRERDSKTSQVPVKHVYRVLQCQEEELTQMVSTMSDGWKFEQLVSIGSSYNYGNEDQAEFLCVVSKELHNTPYGTASEPSEKAKILQERGSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6E1</accession>
    <name>A0A8B7F6E1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Sterol regulatory element-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Sterol regulatory element-binding transcription factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">SREBF1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis and lipid homeostasis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates the promoters of genes involved in cholesterol biosynthesis and the LDL receptor (LDLR) pathway of sterol regulation.</text>
    </comment>
    <comment type="function">
        <text evidence="25">Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 1), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="27">Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with CEBPA, the interaction produces a transcriptional synergy. Interacts with LMNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="28">Forms a tight complex with SCAP, the SCAP-SREBP complex, in the endoplasmic reticulum membrane and the Golgi apparatus. Interacts with PAQR3; the interaction anchors the SCAP-SREBP complex to the Golgi apparatus in low cholesterol conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">COPII-coated vesicle membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the SREBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020613">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603365.2">
        <property type="nucleotide sequence ID" value="XM_012747911.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6E1"/>
    <dbReference type="Ensembl" id="ENSMICT00000012544.3">
        <property type="protein sequence ID" value="ENSMICP00000011425.3"/>
        <property type="gene ID" value="ENSMICG00000012535.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861966"/>
    <dbReference type="CTD" id="6720"/>
    <dbReference type="GeneTree" id="ENSGT00940000159156"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045542">
        <property type="term" value="P:positive regulation of cholesterol biosynthetic process"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18921">
        <property type="entry name" value="bHLHzip_SREBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000016">
        <property type="entry name" value="Sterol regulatory element-binding transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46062:SF2">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="21" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BHLH" evidence="30">
        <location>
            <begin position="328"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="40"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="143"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="426"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="29">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="29">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="29">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="29">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00039749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00042215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00045313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00045371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011425.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1155" mass="122362" checksum="705F7649BF80ED00" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6N5</accession>
    <name>A0A8B7F6N5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nicotinamide N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NNMT</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006993">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603473.1">
        <property type="nucleotide sequence ID" value="XM_012748019.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6N5"/>
    <dbReference type="Ensembl" id="ENSMICT00000052004.2">
        <property type="protein sequence ID" value="ENSMICP00000031827.1"/>
        <property type="gene ID" value="ENSMICG00000027668.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105862036"/>
    <dbReference type="KEGG" id="mmur:105862036"/>
    <dbReference type="CTD" id="4837"/>
    <dbReference type="GeneTree" id="ENSGT00390000011708"/>
    <dbReference type="OrthoDB" id="10050085at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008112">
        <property type="term" value="F:nicotinamide N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD+ catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006769">
        <property type="term" value="P:nicotinamide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045722">
        <property type="term" value="P:positive regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000065">
        <property type="entry name" value="Phenylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025820">
        <property type="entry name" value="NNMT/PNMT/TEMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000940">
        <property type="entry name" value="NNMT_TEMT_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053384">
        <property type="entry name" value="SAM-dep_methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041360">
        <property type="entry name" value="GntF_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867:SF32">
        <property type="entry name" value="NICOTINAMIDE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10867">
        <property type="entry name" value="NNMT/PNMT/TEMT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01234">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000384">
        <property type="entry name" value="PNMTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01100">
        <property type="entry name" value="NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51681">
        <property type="entry name" value="SAM_MT_NNMT_PNMT_TEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="63"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="264" mass="29603" checksum="6647B07A028C3981" modified="2022-01-19" version="1">MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHTAENQILRHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIIVSDYTDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVTQVLKCDVTQSRPLGAVPLPAADCLLSTLCLDAACPDLPSYRTALRNLGSLLKPGGFLVVVDVLKSSYYMIGEQRFSSLSVDRQAVEAAVREAGYAIEQFEVISQNYPSTMANNEGLFFLVGRKLSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FLW6</accession>
    <name>A0A8B7FLW6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kallikrein related peptidase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KLK5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609643.1">
        <property type="nucleotide sequence ID" value="XM_012754189.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FLW6"/>
    <dbReference type="Ensembl" id="ENSMICT00000063999.1">
        <property type="protein sequence ID" value="ENSMICP00000043029.1"/>
        <property type="gene ID" value="ENSMICG00000045803.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105865550"/>
    <dbReference type="KEGG" id="mmur:105865550"/>
    <dbReference type="CTD" id="25818"/>
    <dbReference type="GeneTree" id="ENSGT01020000230389"/>
    <dbReference type="OrthoDB" id="10059102at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097209">
        <property type="term" value="C:epidermal lamellar body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097186">
        <property type="term" value="P:amelogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002803">
        <property type="term" value="P:positive regulation of antibacterial peptide production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045745">
        <property type="term" value="P:positive regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000021">
        <property type="entry name" value="Kallikrein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000010">
        <property type="entry name" value="Kallikrein related peptidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF59">
        <property type="entry name" value="KALLIKREIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133639" evidence="8">
        <location>
            <begin position="30"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="9">
        <location>
            <begin position="65"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="291" mass="30959" checksum="0FD5098DADE5DBB4" modified="2022-01-19" version="1">MATAGPAWTGTLGALIAALLLGVAEPVLANDVSCGNPPAAGHSASNRDLGAGPEEGTRDDSSTRIINGSDCGKHAQPWQAALLLGPNQLYCGAVLVHPQWLLTAAHCRKQGFRVRLGHQSLSPVYESGQQLLRGLKSIPHPGYHHPAHSNDLMLIKLNRRVRVTQDVKPINVSSRCAPAGTKCMVSGWGTTSSPTVHFPKVLQCLNITVLSQDTCKKAYPGQIDHTMFCAGDQAGRDSCQGDSGGPVVCNGRLQGLVSWGDYPCAQPNKPGVYTDLCQFSKWIHNTIQANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FNT1</accession>
    <name>A0A8B7FNT1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger protein 407</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZNF407</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="GDNF-inducible zinc finger protein 1"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <name evidence="10" type="primary">SYNGR2</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
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    </comment>
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        <text evidence="2 6">Belongs to the synaptogyrin family.</text>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0030672">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Marvel"/>
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    <dbReference type="InterPro" id="IPR016579">
        <property type="entry name" value="Synaptogyrin"/>
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    <dbReference type="PANTHER" id="PTHR10838">
        <property type="entry name" value="SYNAPTOGYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10838:SF19">
        <property type="entry name" value="SYNAPTOGYRIN-2 LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51225">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="9">
        <location>
            <begin position="20"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR011282"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="224" mass="24762" checksum="EFBF877C81B82BB4" modified="2022-01-19" version="1">MESGAYGAAKAGGSFDLRRFLAQPQVVARAVCMVFALIVFSCIFGEGYSNTHSSKQMYCVFNHNEDACRYGSAIGVLAFLASAFFLVVDVYFPQMSNVTDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAATKKEDVLVGADSARAAIAFSFFSIFSWGMLASLAYQRYKAGVEDFTQNYVDPTPDPSTAYASYPGAPVDTYQQPPFTQSAETTEGYQPPPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FYG7</accession>
    <name>A0A8B7FYG7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="13">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DTX2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the Deltex family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="13"/>
    <dbReference type="EMBL" id="ABDC03021087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614524.1">
        <property type="nucleotide sequence ID" value="XM_012759070.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614525.1">
        <property type="nucleotide sequence ID" value="XM_012759071.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020137182.1">
        <property type="nucleotide sequence ID" value="XM_020281593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FYG7"/>
    <dbReference type="Ensembl" id="ENSMICT00000014106.3">
        <property type="protein sequence ID" value="ENSMICP00000012860.2"/>
        <property type="gene ID" value="ENSMICG00000014104.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868342"/>
    <dbReference type="KEGG" id="mmur:105868342"/>
    <dbReference type="CTD" id="113878"/>
    <dbReference type="GeneTree" id="ENSGT00940000157641"/>
    <dbReference type="OrthoDB" id="2449614at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16672">
        <property type="entry name" value="RING-H2_DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000097">
        <property type="entry name" value="E3 ubiquitin-protein ligase DTX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000004">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.50:FF:000005">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.130:FF:000001">
        <property type="entry name" value="Probable E3 ubiquitin-protein ligase DTX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 12 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="WWE" evidence="16">
        <location>
            <begin position="98"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="409"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="249"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012860.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="619" mass="66987" checksum="F7E33B599CFA5EAC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G5W0</accession>
    <name>A0A8B7G5W0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Jade family PHD finger 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">JADE2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the JADE family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012762182.2"/>
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        <property type="nucleotide sequence ID" value="XM_012762183.1"/>
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        <property type="nucleotide sequence ID" value="XM_012762184.2"/>
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        <property type="nucleotide sequence ID" value="XM_012762185.2"/>
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        <property type="nucleotide sequence ID" value="XM_012762186.1"/>
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        <property type="nucleotide sequence ID" value="XM_012762187.1"/>
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        <property type="nucleotide sequence ID" value="XM_012762188.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000023633.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158570"/>
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        <property type="component" value="Chromosome 19"/>
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        <property type="term" value="C:histone acetyltransferase complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of neurogenesis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="entry name" value="Protein Jade-1 isoform 1"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Enhancer_polycomb-like_N"/>
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        <property type="entry name" value="EPHD"/>
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        <property type="entry name" value="Histone_Mod_Regulator"/>
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        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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        <property type="entry name" value="Znf_FYVE_PHD"/>
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        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE JADE-2"/>
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    </dbReference>
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        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="199"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="9">
        <location>
            <begin position="251"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="108"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="517"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    <feature type="compositionally biased region" description="Basic residues" evidence="7">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="7">
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038371"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="841" mass="92558" checksum="CF1F9F92EBC7B58F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8Y8</accession>
    <name>A0A8B7G8Y8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable inactive allantoicase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Allantoate amidinohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ALLC</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the allantoicase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012257">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012258">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012260">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618619.1">
        <property type="nucleotide sequence ID" value="XM_012763165.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8Y8"/>
    <dbReference type="Ensembl" id="ENSMICT00000016176.3">
        <property type="protein sequence ID" value="ENSMICP00000014743.2"/>
        <property type="gene ID" value="ENSMICG00000016182.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870522"/>
    <dbReference type="KEGG" id="mmur:105870522"/>
    <dbReference type="CTD" id="55821"/>
    <dbReference type="GeneTree" id="ENSGT00390000001793"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004037">
        <property type="term" value="F:allantoicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000077">
        <property type="entry name" value="Probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000085">
        <property type="entry name" value="probable allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00813">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005164">
        <property type="entry name" value="Allantoicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015908">
        <property type="entry name" value="Allantoicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02961">
        <property type="entry name" value="allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045">
        <property type="entry name" value="ALLANTOICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12045:SF3">
        <property type="entry name" value="INACTIVE ALLANTOICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03561">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016516">
        <property type="entry name" value="Allantoicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Allantoicase" evidence="5">
        <location>
            <begin position="224"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014743.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="413" mass="46099" checksum="FCABD08B1E21D891" modified="2022-01-19" version="1">MAEAPREGKLTRFLDFTQLIDLASESVGGKVLFATDDFFAPAENLIKSDGPSFKEHEYTEFGKWMDGWETRRKRTPGHDWCVIRLGIPGIIRGFDVDLSYFEGSHAPRMSIQAANVEEDQLPKIPERGGVRTGASATPEELDAIAELKSNGWNYLVPMTELKPGKPAESHNYFLVNSPQRWTHIRLNIFPDGGIARLRAYGTGQKDWTATDPKDPEDLAAIAYGGVCVGFSNAHFGHPNNMIGVGEAKSMADGWRTARRLDRPPILESDDSGTLLVPGSEWAVFRLAHPGVITHIEIDTRYFKGNSPDSCKVDGCILTTQEEEDMVKHKWLLPAHKWKALLPVTKLSPNQSHLFDSLTVELQDVITHARLTIFPDGGVSRLRLKGFPSSICLLRHREKPQMRFSVKSGFRANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GAX5</accession>
    <name>A0A8B7GAX5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Homeobox C5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HOXC5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the Antp homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619708.1">
        <property type="nucleotide sequence ID" value="XM_012764254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GAX5"/>
    <dbReference type="SMR" id="A0A8B7GAX5"/>
    <dbReference type="Ensembl" id="ENSMICT00000066178.1">
        <property type="protein sequence ID" value="ENSMICP00000049529.1"/>
        <property type="gene ID" value="ENSMICG00000042167.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105871094"/>
    <dbReference type="KEGG" id="mmur:105871094"/>
    <dbReference type="CTD" id="3222"/>
    <dbReference type="GeneTree" id="ENSGT00940000161023"/>
    <dbReference type="OMA" id="AYTMQSY"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000055">
        <property type="entry name" value="Homeobox protein Hox-A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF13">
        <property type="entry name" value="HOMEOBOX C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="9 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="14">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="155"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="68"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="222" mass="24992" checksum="95D763BF5E4E7AC7" modified="2022-01-19" version="1">MSSYVANSFYKQSPNIPAYNMQTCGNYGSASEVQASRYCYGGLDLSITFPPPAPSNSLHGVDMAANPRAHPDRPACSAAAAPGHALGRDEAAPLNPGMYSQKAARPALEERAKSSGEIKEEQAQTGQPAGLSQPPAPPQIYPWMTKLHMSHETDGKRSRTSYTRYQTLELEKEFHFNRYLTRRRRIEIANNLCLNERQIKIWFQNRRMKWKKDSKMKSKEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GBT4</accession>
    <name>A0A8B7GBT4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BAF chromatin remodeling complex subunit BCL7C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BCL7C</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the BCL7 family.</text>
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        <source>
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        <source>
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</entry>
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    <accession>A0A8B7GDJ3</accession>
    <name>A0A8B7GDJ3_MICMU</name>
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        <submittedName>
            <fullName evidence="7">Zinc finger MYM-type containing 6</fullName>
        </submittedName>
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        <name evidence="7" type="primary">ZMYM6</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="component" value="Chromosome 2"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="TRASH_dom"/>
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        <property type="entry name" value="Znf_MYM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051284">
        <property type="entry name" value="ZnF_MYMT-QRICH1"/>
    </dbReference>
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        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45736:SF9">
        <property type="entry name" value="ZINC FINGER MYM-TYPE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24900">
        <property type="entry name" value="TRASH_ZMYM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06467">
        <property type="entry name" value="zf-FCS"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
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        </alternativeName>
    </protein>
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        <name evidence="17" type="primary">UBE2U</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the covalent attachment of ubiquitin to other proteins.</text>
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        <text evidence="7">Protein modification.</text>
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    <comment type="similarity">
        <text evidence="14">Belongs to the ubiquitin-conjugating enzyme family.</text>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23806">
        <property type="entry name" value="UBCc_UBE2U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000067">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 U isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="16">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="240"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="13">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="316" mass="36510" checksum="19A88B5D12A09C6D" modified="2022-01-19" version="1">MHCRAYLLLERDFQEFKMNDFEGIIVVPVSEDLMKWEAEIRGLQNTISHELVFQLTMDFTTEYSYVPPVVKFKPIPFHPNVNPQTGRPCIDFLDNPSKWNERYTLSSILLALQVMLSNPVPENPVNFEAAQILMKDKSLYRTITLKLFKEPSQSKDDSQNLPEEPQKGTGPVKTISFNDYYKTWSEIATSKATEFDRTPLLEDPNFIGQYYKWRKMDLQYPKEWKLRFGALKSRFARKDGMPHRASHSTERGHLCPTPDDISSEPQTAISIITGAYETEEELESDTTSSDNNESWEEEVDSLVAWTSALNTETLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GP83</accession>
    <name>A0A8B7GP83_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tomoregulin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transmembrane protein with EGF-like and one follistatin-like domain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TMEFF1</name>
        <name evidence="20" type="synonym">MSANTD3</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">May interact with ST14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the tomoregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014683">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014684">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624430.1">
        <property type="nucleotide sequence ID" value="XM_012768976.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GP83"/>
    <dbReference type="Ensembl" id="ENSMICT00000005351.3">
        <property type="protein sequence ID" value="ENSMICP00000004877.3"/>
        <property type="gene ID" value="ENSMICG00000005352.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873762"/>
    <dbReference type="CTD" id="8577"/>
    <dbReference type="GeneTree" id="ENSGT00940000160714"/>
    <dbReference type="OrthoDB" id="328123at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046597">
        <property type="term" value="P:host-mediated suppression of symbiont invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000051">
        <property type="entry name" value="LOW QUALITY PROTEIN: tomoregulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000233">
        <property type="entry name" value="tomoregulin-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000002">
        <property type="entry name" value="tomoregulin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21632">
        <property type="entry name" value="REGULATORY PROTEIN ZESTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21632:SF3">
        <property type="entry name" value="TOMOREGULIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="10 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 15" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="19">
        <location>
            <begin position="98"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="19">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="18">
        <location>
            <begin position="271"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004877.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="380" mass="40897" checksum="5064370B44E7D0CC" modified="2022-01-19" version="1">MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGSGGGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVVARGPCYSDTGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMSCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQNLGHFTSDTSSRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H2H7</accession>
    <name>A0A8B7H2H7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP-Gly domain containing linker protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CLIP3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630420.1">
        <property type="nucleotide sequence ID" value="XM_012774966.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H2H7"/>
    <dbReference type="Ensembl" id="ENSMICT00000059262.1">
        <property type="protein sequence ID" value="ENSMICP00000048583.1"/>
        <property type="gene ID" value="ENSMICG00000042734.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000063818.1">
        <property type="protein sequence ID" value="ENSMICP00000047220.1"/>
        <property type="gene ID" value="ENSMICG00000042734.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105876894"/>
    <dbReference type="KEGG" id="mmur:105876894"/>
    <dbReference type="CTD" id="25999"/>
    <dbReference type="GeneTree" id="ENSGT00940000159557"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000044">
        <property type="entry name" value="CAP-Gly domain containing linker protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000005">
        <property type="entry name" value="CAP-Gly domain containing linker protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000011">
        <property type="entry name" value="CAP-Gly domain-containing linker protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF77">
        <property type="entry name" value="CAP-GLY DOMAIN-CONTAINING LINKER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="315"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="366"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="548" mass="59666" checksum="2C261F523310234F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H2N4</accession>
    <name>A0A8B7H2N4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin-folding cofactor B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cytoskeleton-associated protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Cytoskeleton-associated protein CKAPI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Tubulin-specific chaperone B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">TBCB</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. Interacts with GAN. Interacts with DCTN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630416.1">
        <property type="nucleotide sequence ID" value="XM_012774962.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H2N4"/>
    <dbReference type="Ensembl" id="ENSMICT00000047913.2">
        <property type="protein sequence ID" value="ENSMICP00000034162.1"/>
        <property type="gene ID" value="ENSMICG00000033775.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876889"/>
    <dbReference type="KEGG" id="mmur:105876889"/>
    <dbReference type="CTD" id="1155"/>
    <dbReference type="GeneTree" id="ENSGT00940000156119"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000217">
        <property type="entry name" value="Tubulin folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-0221">Differentiation</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="CAP-Gly" evidence="19">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="244" mass="27356" checksum="B3F9E0A81002C4B5" modified="2022-01-19" version="1">MEVTGVTAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKCKLELVVGSPASCMELELYGADDKFYSKLDQEDALLGSYPVDDGCRIHVIDHSGARLGEYEDVAKVEKYEISQEAYDQRQDTVRSFLKRSKLGRYNEEERAQQEAEATQRLAEEKAQASAIPVGSRCEVRAPGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPSVVTVGDFPEEDYGLDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H7R1</accession>
    <name>A0A8B7H7R1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cyclin-dependent kinase 4</fullName>
            <ecNumber evidence="3">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cell division protein kinase 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">CDK4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03009713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632578.1">
        <property type="nucleotide sequence ID" value="XM_012777124.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632580.1">
        <property type="nucleotide sequence ID" value="XM_012777126.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632581.1">
        <property type="nucleotide sequence ID" value="XM_012777127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H7R1"/>
    <dbReference type="Ensembl" id="ENSMICT00000003783.3">
        <property type="protein sequence ID" value="ENSMICP00000003449.3"/>
        <property type="gene ID" value="ENSMICG00000003789.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877995"/>
    <dbReference type="KEGG" id="mmur:105877995"/>
    <dbReference type="CTD" id="1019"/>
    <dbReference type="GeneTree" id="ENSGT00940000154770"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097128">
        <property type="term" value="C:cyclin D1-CDK4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097129">
        <property type="term" value="C:cyclin D2-CDK4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097130">
        <property type="term" value="C:cyclin D3-CDK4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904637">
        <property type="term" value="P:cellular response to ionomycin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904628">
        <property type="term" value="P:cellular response to phorbol 13-acetate 12-myristate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048146">
        <property type="term" value="P:positive regulation of fibroblast proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061469">
        <property type="term" value="P:regulation of type B pancreatic cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000124">
        <property type="entry name" value="Cyclin-dependent kinase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000205">
        <property type="entry name" value="Cyclin-dependent kinase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF129">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 17 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="6"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003449.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="303" mass="33777" checksum="8F4DF27D30506773" modified="2022-01-19" version="1">MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGAGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHIDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLRKDEGNPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBP2</accession>
    <name>A0A8B7HBP2_MICMU</name>
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        <submittedName>
            <fullName evidence="1">Armadillo repeat containing 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ARMC7</name>
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    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634223.1">
        <property type="nucleotide sequence ID" value="XM_012778769.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000065025.1">
        <property type="protein sequence ID" value="ENSMICP00000044854.1"/>
        <property type="gene ID" value="ENSMICG00000043029.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878926"/>
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    <dbReference type="CTD" id="79637"/>
    <dbReference type="GeneTree" id="ENSGT00940000162633"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042462">
        <property type="entry name" value="ARMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46263:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="198" mass="21665" checksum="AEC2C0C081C58CAA" modified="2022-01-19" version="1">MAQKPKVDPHVGRLGYLQALVTEFQETESQDAKEQVLANLANFAYDPNNYQYLRQLQVLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKEHILQAGGIPLITNCLSSPNEETVLSAVTTLIYLGSAGPGCHPELTALPVVQCMLRFSLSTNTRLRNLAQIFLEDLCSPSQVAEARSRQAHSALGIPLPRTAAPEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HC71</accession>
    <name>A0A8B7HC71_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc finger translocation associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ZFTA</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005872">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633306.1">
        <property type="nucleotide sequence ID" value="XM_012777852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HC71"/>
    <dbReference type="Ensembl" id="ENSMICT00000015219.3">
        <property type="protein sequence ID" value="ENSMICP00000013884.2"/>
        <property type="gene ID" value="ENSMICG00000015216.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878453"/>
    <dbReference type="KEGG" id="mmur:105878453"/>
    <dbReference type="CTD" id="65998"/>
    <dbReference type="GeneTree" id="ENSGT00600000084617"/>
    <dbReference type="OrthoDB" id="9945249at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040647">
        <property type="entry name" value="SPIN-DOC_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052675">
        <property type="entry name" value="ZnF_transloc-Spindlin_int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589">
        <property type="entry name" value="SIMILAR TO RIKEN CDNA 2700081O15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34589:SF2">
        <property type="entry name" value="ZINC FINGER TRANSLOCATION-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18658">
        <property type="entry name" value="zf-C2H2_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
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            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013884.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="675" mass="72927" checksum="B4195F85691850F8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HCN1</accession>
    <name>A0A8B7HCN1_MICMU</name>
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        <submittedName>
            <fullName evidence="11">Solute carrier family 13 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC13A5</name>
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    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012779173.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012779174.2"/>
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    <dbReference type="GeneTree" id="ENSGT01030000234550"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031312">
        <property type="entry name" value="Na/sul_symport_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF109">
        <property type="entry name" value="NA(+)_CITRATE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01271">
        <property type="entry name" value="NA_SULFATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="12"/>
            <end position="33"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033967.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HI13</accession>
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        <submittedName>
            <fullName evidence="13">Myocyte enhancer factor 2C</fullName>
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        <name evidence="13" type="primary">MEF2C</name>
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        <name type="scientific">Microcebus murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EMBL" id="ABDC03016900">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012781466.2"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012781467.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012781469.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012781470.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012781471.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636926.1">
        <property type="nucleotide sequence ID" value="XM_012781472.3"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012781473.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145770.1">
        <property type="nucleotide sequence ID" value="XM_020290181.1"/>
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    <dbReference type="SMR" id="A0A8B7HI13"/>
    <dbReference type="Ensembl" id="ENSMICT00000053482.2">
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        <property type="gene ID" value="ENSMICG00000034356.2"/>
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    <dbReference type="GeneID" id="105880434"/>
    <dbReference type="KEGG" id="mmur:105880434"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157492"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="12">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="180"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="375"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="473" mass="51221" checksum="A7982020BB8C8949" modified="2022-01-19" version="1">MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVSIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNMQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HQM0</accession>
    <name>A0A8B7HQM0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Cyclin-dependent kinase-like 5</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CDKL5</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mediates phosphorylation of MECP2. May regulate ciliogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with MECP2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03035959">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640149.1">
        <property type="nucleotide sequence ID" value="XM_012784695.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HQM0"/>
    <dbReference type="Ensembl" id="ENSMICT00000046321.2">
        <property type="protein sequence ID" value="ENSMICP00000018804.2"/>
        <property type="gene ID" value="ENSMICG00000004179.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882381"/>
    <dbReference type="CTD" id="6792"/>
    <dbReference type="GeneTree" id="ENSGT00940000157355"/>
    <dbReference type="OrthoDB" id="9929178at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032839">
        <property type="term" value="C:dendrite cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045773">
        <property type="term" value="P:positive regulation of axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050773">
        <property type="term" value="P:regulation of dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07848">
        <property type="entry name" value="STKc_CDKL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001093">
        <property type="entry name" value="Cyclin-dependent kinase-like 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000127">
        <property type="entry name" value="Putative cyclin-dependent kinase-like 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF111">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="13"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="298"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="383"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="516"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="646"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="878"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="434"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="516"/>
            <end position="548"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="549"/>
            <end position="559"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="679"/>
            <end position="704"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="22">
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        <location>
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        <location>
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        <location>
            <begin position="880"/>
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        <location>
            <begin position="914"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <evidence type="ECO:0000256" key="22">
        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="960" mass="107480" checksum="CB8F37F55C4A3A3B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HUR8</accession>
    <name>A0A8B7HUR8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Retinol dehydrogenase 10</fullName>
            <ecNumber evidence="5">1.1.1.300</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RDH10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Microsome membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03012846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641822.2">
        <property type="nucleotide sequence ID" value="XM_012786368.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HUR8"/>
    <dbReference type="Ensembl" id="ENSMICT00000002878.3">
        <property type="protein sequence ID" value="ENSMICP00000002621.3"/>
        <property type="gene ID" value="ENSMICG00000002884.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105883307"/>
    <dbReference type="CTD" id="157506"/>
    <dbReference type="GeneTree" id="ENSGT00940000157063"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="UniPathway" id="UPA00912"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060449">
        <property type="term" value="P:bud elongation involved in lung branching"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043583">
        <property type="term" value="P:ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031076">
        <property type="term" value="P:embryonic camera-type eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035115">
        <property type="term" value="P:embryonic forelimb morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048703">
        <property type="term" value="P:embryonic viscerocranium morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001656">
        <property type="term" value="P:metanephros development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043584">
        <property type="term" value="P:nose development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060431">
        <property type="term" value="P:primary lung bud formation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042574">
        <property type="term" value="P:retinal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:retinoic acid biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Retinol dehydrogenase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002621.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="341" mass="38175" checksum="240A050E57D16FAC" modified="2022-01-19" version="1">MNIVVEFFVVTFKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLWLWDINTQSNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKEIEPFLPPLKPDYCVKQAMKAILTDQPMICTPRLMYIVTFMKSILPFEAVVCMYRFLGADKCMYPFIAQRKQATNNNEAKNGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HY21</accession>
    <name>A0A8B7HY21_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integrin alpha-IIb</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">GPalpha IIb</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Platelet membrane glycoprotein IIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">ITGA2B</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. Interacts (via C-terminus cytoplasmic tail region) with CIB1; the interaction is direct and calcium-dependent. Interacts (via C-terminus cytoplasmic tail region) with CIB2, CIB3 and CIB4; the interactions are stabilized/increased in a calcium and magnesium-dependent manner. ITGA2B:ITGB3 interacts with PPIA/CYPA; the interaction is ROS and PPIase activity-dependent and is increased in the presence of thrombin. ITGA2B:ITGB3 interacts with SELP (via C-type lectin domain); the interaction mediates cell-cell interaction and adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21">Membrane</location>
            <topology evidence="1 21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 21">Belongs to the integrin alpha chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020189">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642183.1">
        <property type="nucleotide sequence ID" value="XM_012786729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HY21"/>
    <dbReference type="Ensembl" id="ENSMICT00000005165.3">
        <property type="protein sequence ID" value="ENSMICP00000004709.3"/>
        <property type="gene ID" value="ENSMICG00000005146.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883554"/>
    <dbReference type="KEGG" id="mmur:105883554"/>
    <dbReference type="CTD" id="3674"/>
    <dbReference type="GeneTree" id="ENSGT00940000160724"/>
    <dbReference type="OrthoDB" id="5317514at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070442">
        <property type="term" value="C:integrin alphaIIb-beta3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005178">
        <property type="term" value="F:integrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033627">
        <property type="term" value="P:cell adhesion mediated by integrin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007229">
        <property type="term" value="P:integrin-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1510:FF:000001">
        <property type="entry name" value="Integrin alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.130:FF:000012">
        <property type="entry name" value="Integrin alpha-IIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.930:FF:000001">
        <property type="entry name" value="Integrin subunit alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1460:FF:000001">
        <property type="entry name" value="Integrin, alpha V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.930">
        <property type="entry name" value="Bicelle-embedded integrin alpha(iib) transmembrane segment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="entry name" value="Integrin alpha, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1460">
        <property type="entry name" value="Integrin domains. Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1510">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1530">
        <property type="entry name" value="ntegrin, alpha v. Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013519">
        <property type="entry name" value="Int_alpha_beta-p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000413">
        <property type="entry name" value="Integrin_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018184">
        <property type="entry name" value="Integrin_alpha_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013649">
        <property type="entry name" value="Integrin_alpha_Ig-like_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048285">
        <property type="entry name" value="Integrin_alpha_Ig-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048286">
        <property type="entry name" value="Integrin_alpha_Ig-like_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032695">
        <property type="entry name" value="Integrin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220">
        <property type="entry name" value="INTEGRIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23220:SF73">
        <property type="entry name" value="INTEGRIN ALPHA-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01839">
        <property type="entry name" value="FG-GAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08441">
        <property type="entry name" value="Integrin_A_Ig_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20805">
        <property type="entry name" value="Integrin_A_Ig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20806">
        <property type="entry name" value="Integrin_A_Ig_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01185">
        <property type="entry name" value="INTEGRINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00191">
        <property type="entry name" value="Int_alpha"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69179">
        <property type="entry name" value="Integrin domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51470">
        <property type="entry name" value="FG_GAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00242">
        <property type="entry name" value="INTEGRIN_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 21" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 21" id="KW-0401">Integrin</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 21" id="KW-0732">Signal</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044038189" description="Integrin alpha-IIb" evidence="21">
        <location>
            <begin position="32"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="20">
        <location>
            <begin position="35"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="20">
        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="20">
        <location>
            <begin position="373"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="FG-GAP" evidence="20">
        <location>
            <begin position="435"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha first immunoglubulin-like" evidence="23">
        <location>
            <begin position="481"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha second immunoglobulin-like" evidence="24">
        <location>
            <begin position="633"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Integrin alpha third immunoglobulin-like" evidence="25">
        <location>
            <begin position="779"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="855"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="882"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00064174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF20805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF20806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004709.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1039" mass="113155" checksum="7081BD9838AF8B57" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I0Q1</accession>
    <name>A0A8B7I0Q1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RAB9B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Phagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03034290">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643350.1">
        <property type="nucleotide sequence ID" value="XM_012787896.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I0Q1"/>
    <dbReference type="Ensembl" id="ENSMICT00000003055.3">
        <property type="protein sequence ID" value="ENSMICP00000034111.1"/>
        <property type="gene ID" value="ENSMICG00000003057.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884180"/>
    <dbReference type="KEGG" id="mmur:105884180"/>
    <dbReference type="CTD" id="51209"/>
    <dbReference type="GeneTree" id="ENSGT00940000160481"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032482">
        <property type="term" value="P:Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04116">
        <property type="entry name" value="Rab9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000360">
        <property type="entry name" value="RAB9B, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041824">
        <property type="entry name" value="Rab9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF17">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="201" mass="22703" checksum="46D534F76333D463" modified="2022-01-19" version="1">MSGKSLLLKVILLGDGGVGKSSLMNRYVTNKFDSQAFHTIGVEFLNRDLEVDGRFVTLQIWDTAGQERFKSLRTPFYRGADCCLLTFSVDDRQSFENLANWQKEFIYYADVKDPEHFPFVVLGNKVDKEDRQVTTEEAQAWCMENGDYPYLETSAKDDTNVTVAFEEAVRQVLAVEEQLEHCMLGHTIDLNSGSKAGSSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I0R6</accession>
    <name>A0A8B7I0R6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholipase A2</fullName>
            <ecNumber evidence="12">3.1.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PLA2G5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30245"/>
            <dbReference type="ChEBI" id="CHEBI:73004"/>
            <dbReference type="ChEBI" id="CHEBI:73008"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:40816"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38779"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
            <dbReference type="ChEBI" id="CHEBI:73001"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:38780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:15802"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the phospholipase A2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.4" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03001951">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643130.1">
        <property type="nucleotide sequence ID" value="XM_012787676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I0R6"/>
    <dbReference type="Ensembl" id="ENSMICT00000014399.3">
        <property type="protein sequence ID" value="ENSMICP00000013127.2"/>
        <property type="gene ID" value="ENSMICG00000045448.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000058447.1">
        <property type="protein sequence ID" value="ENSMICP00000047231.1"/>
        <property type="gene ID" value="ENSMICG00000045448.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000060793.1">
        <property type="protein sequence ID" value="ENSMICP00000041139.1"/>
        <property type="gene ID" value="ENSMICG00000045448.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067681.1">
        <property type="protein sequence ID" value="ENSMICP00000041961.1"/>
        <property type="gene ID" value="ENSMICG00000045448.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105884003"/>
    <dbReference type="KEGG" id="mmur:105884002"/>
    <dbReference type="GeneTree" id="ENSGT00940000162222"/>
    <dbReference type="OrthoDB" id="5841574at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047498">
        <property type="term" value="F:calcium-dependent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050482">
        <property type="term" value="P:arachidonate secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019370">
        <property type="term" value="P:leukotriene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042130">
        <property type="term" value="P:negative regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034638">
        <property type="term" value="P:phosphatidylcholine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070374">
        <property type="term" value="P:positive regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090265">
        <property type="term" value="P:positive regulation of immune complex clearance by monocytes and macrophages"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00125">
        <property type="entry name" value="PLA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.90.10:FF:000001">
        <property type="entry name" value="Basic phospholipase A2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.90.10">
        <property type="entry name" value="Phospholipase A2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001211">
        <property type="entry name" value="PLA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016090">
        <property type="entry name" value="PLA2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033112">
        <property type="entry name" value="PLA2_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033113">
        <property type="entry name" value="PLA2_histidine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036444">
        <property type="entry name" value="PLipase_A2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716">
        <property type="entry name" value="PHOSPHOLIPASE A2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11716:SF10">
        <property type="entry name" value="PHOSPHOLIPASE A2 GROUP V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00068">
        <property type="entry name" value="Phospholip_A2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00389">
        <property type="entry name" value="PHPHLIPASEA2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00085">
        <property type="entry name" value="PA2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48619">
        <property type="entry name" value="Phospholipase A2, PLA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00119">
        <property type="entry name" value="PA2_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00118">
        <property type="entry name" value="PA2_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519628" description="Phospholipase A2" evidence="12">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase A2-like central" evidence="13">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601211-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="138" mass="15657" checksum="EB8507ADFE2D039E" modified="2022-01-19" version="1">MKGLLPLAWFLAYSVPAVPGGLLQLKSMIEKVTGKNALVNYGFYGCYCGWGGRGTPKDVTDWCCWVHDRCYGSLEDRGCNIRTQTYGYRFAWGLVTCEAGPSCGVQLCACDRQLVYCLRRNLRSYNPRYRYFPNVFCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I693</accession>
    <name>A0A8B7I693_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein Dr1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Down-regulator of transcription 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Negative cofactor 2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">TATA-binding protein-associated phosphoprotein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DR1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NC2 beta/DR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002766">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646417.1">
        <property type="nucleotide sequence ID" value="XM_012790963.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I693"/>
    <dbReference type="Ensembl" id="ENSMICT00000043397.2">
        <property type="protein sequence ID" value="ENSMICP00000029332.1"/>
        <property type="gene ID" value="ENSMICG00000028249.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885743"/>
    <dbReference type="KEGG" id="mmur:105885743"/>
    <dbReference type="CTD" id="1810"/>
    <dbReference type="GeneTree" id="ENSGT00550000075010"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="176" mass="19444" checksum="C6B2E59F2FD6CAB3" modified="2022-01-19" version="1">MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQIAAASASASNQAGSSQDEEDDDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WTL5</accession>
    <name>A0A8B7WTL5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Leucine rich repeat containing 75B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LRRC75B</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the LRRC75 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024698">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138702.1">
        <property type="nucleotide sequence ID" value="XM_020283113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WTL5"/>
    <dbReference type="Ensembl" id="ENSMICT00000042851.2">
        <property type="protein sequence ID" value="ENSMICP00000035989.2"/>
        <property type="gene ID" value="ENSMICG00000030419.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105862757"/>
    <dbReference type="CTD" id="388886"/>
    <dbReference type="GeneTree" id="ENSGT00940000162815"/>
    <dbReference type="OrthoDB" id="9979103at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000158">
        <property type="entry name" value="Leucine rich repeat containing 75A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39654">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39654:SF5">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 75B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00060993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035989.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="34632" checksum="4E9B4F32E49A90D6" modified="2022-01-19" version="1">MGARLGRRAAQAGSEARAAAGGGPAPYERRVRWLREIQSTLRERRPEHARQLLRLLRQDLGLEGTLLTDILYRDVAFLNLVDPISHDLLVNLARDLQCPKKDYELWKSSDKICRQLIYHLTPHSKQQRGSSLSRRRTQSCLKSSLQKTLLAGETVDLSGIPLSAQDVQHITRYLGSHGAGLAVLDLSFTELSDELLRLLLPSLWTLPRLTQLLLNGNRLTQATARELTEAIKDTTKFPTLAWVDLGNNVDVASLPQPLLVGLRRRLSQRTSLPTIYEGLDLEPGGCAAEATAHASTWGSAAAGTAPEPQACCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X352</accession>
    <name>A0A8B7X352_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ubiquitin carboxyl-terminal hydrolase 8</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">Deubiquitinating enzyme 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Ubiquitin isopeptidase Y</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Ubiquitin thioesterase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Ubiquitin-specific-processing protease 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">USP8</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 32 33">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Forms a ternary complex with RNF128 and OTUB1. Interacts (via C-terminal UCH catalytic domain) with OTUB1 isoform 1. Interacts with STAM2 (via SH3 domain). Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG and YWHAZ. Interacts with NBR1, RASGRF1, RNF41 and IST1. Associates with the ESCRT-0 complex and with microtubules. Interacts with BIRC6/bruce and KIF23/MKLP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03004525">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004526">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020141515.1">
        <property type="nucleotide sequence ID" value="XM_020285926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X352"/>
    <dbReference type="Ensembl" id="ENSMICT00000066832.1">
        <property type="protein sequence ID" value="ENSMICP00000043525.1"/>
        <property type="gene ID" value="ENSMICG00000005859.3"/>
    </dbReference>
    <dbReference type="CTD" id="9101"/>
    <dbReference type="GeneTree" id="ENSGT00940000157542"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002080">
        <property type="term" value="C:acrosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905166">
        <property type="term" value="P:negative regulation of lysosomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905908">
        <property type="term" value="P:positive regulation of amyloid fibril formation"/>
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</entry>
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                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
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                <person name="Rajbhandari K."/>
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                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
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                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665410" evidence="5">
        <location>
            <begin position="27"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="6">
        <location>
            <begin position="30"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="RefSeq" id="XP_012629066.1"/>
        </source>
    </evidence>
    <sequence length="365" mass="39047" checksum="732508E11055CE3D" modified="2022-01-19" version="1">MALPPGLATLSHTLLLLPALLSSGWGELAPQIDGQTWAERALRENERHAFTCRVAGGPGTPRLAWYLDGQLQEASTSRLLSVGGEAFSGGTSTFTITAQRAQHELNCSLRDPGSGQSANASVILNVQFKPEIAQVGAKYQEAQGPGLLVVLFALVRANPPANVTWIDQNGPVTVNTSDFLVLDAQNYPWLTNHTVQLQLHSLAHNLSVVATNDVGVTSASLPAPGLLATRVEVPLLGIVVAGGLALGTLVGFSTLVACLVCRKEKKTKGPSRRPSLVSSDSNNLKLNNVRLPRENMSLPSNLQLNDLTPDSRGKSADQQMTRNNSRPELLDPEPGGLLTSRGFIRLPMLGYIYRVSSVSSDEIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UHV1</accession>
    <name>A0A8C5UHV1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Olfactomedin like 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">OLFML2B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624068.1">
        <property type="nucleotide sequence ID" value="XM_012768614.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UHV1"/>
    <dbReference type="Ensembl" id="ENSMICT00000000042.3">
        <property type="protein sequence ID" value="ENSMICP00000000039.2"/>
        <property type="gene ID" value="ENSMICG00000000040.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873569"/>
    <dbReference type="CTD" id="25903"/>
    <dbReference type="GeneTree" id="ENSGT00940000157757"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050840">
        <property type="term" value="F:extracellular matrix binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF37">
        <property type="entry name" value="OLFACTOMEDIN-LIKE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149825" evidence="5">
        <location>
            <begin position="21"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Olfactomedin-like" evidence="6">
        <location>
            <begin position="494"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="366"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000039.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="751" mass="83251" checksum="126DE895300D2BE6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UHZ0</accession>
    <name>A0A8C5UHZ0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TEA domain transcription factor 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TEAD4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010477">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UHZ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000000106.3">
        <property type="protein sequence ID" value="ENSMICP00000000097.3"/>
        <property type="gene ID" value="ENSMICG00000000108.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182956"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001708">
        <property type="term" value="P:cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902459">
        <property type="term" value="P:positive regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001830">
        <property type="term" value="P:trophectodermal cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016361">
        <property type="entry name" value="TEF_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041086">
        <property type="entry name" value="YBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17725">
        <property type="entry name" value="YBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002603">
        <property type="entry name" value="TEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00065">
        <property type="entry name" value="TEADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00554">
        <property type="entry name" value="TEA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="9">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="7">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000097.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="426" mass="48353" checksum="3D8D859034994660" modified="2025-10-08" version="2">MEGKAGTITSNEWSSPNSPEGSNGSGGSQALDKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKVRHAAVGGVGVRSWGPFPSRMSLPLAFRGPWFPELQSFVWIRYPGRDASCCVKPFSQQTYAVQPPLLLWFESPAGPMPSPSAPPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKELFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5ULM8</accession>
    <name>A0A8C5ULM8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Integral membrane protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ITM2B</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the ITM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017732">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017733">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145983.1">
        <property type="nucleotide sequence ID" value="XM_020290394.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5ULM8"/>
    <dbReference type="Ensembl" id="ENSMICT00000001758.3">
        <property type="protein sequence ID" value="ENSMICP00000001601.3"/>
        <property type="gene ID" value="ENSMICG00000001759.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855964"/>
    <dbReference type="KEGG" id="mmur:105855964"/>
    <dbReference type="CTD" id="9445"/>
    <dbReference type="GeneTree" id="ENSGT00950000183115"/>
    <dbReference type="OMA" id="YFAFQQD"/>
    <dbReference type="OrthoDB" id="9982095at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001540">
        <property type="term" value="F:amyloid-beta binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042985">
        <property type="term" value="P:negative regulation of amyloid precursor protein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007084">
        <property type="entry name" value="BRICHOS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040145">
        <property type="entry name" value="ITM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10962">
        <property type="entry name" value="INTEGRAL TRANSMEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04089">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01039">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50869">
        <property type="entry name" value="BRICHOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="BRICHOS" evidence="18">
        <location>
            <begin position="137"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU367061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001601.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="266" mass="30349" checksum="4C93FF77DD3F4FD2" modified="2022-01-19" version="1">MVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPDDVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAARYQTIEENIKIFEDDEVEFISVPVPEFADSDPANIVHDFNKKLTAYLDLNLDKCYVIPLNTSIVMPPRNLLELLINIKAGTYLPQSYLIHEHMVITDRIENVDHLGFFIYRLCHDKETYKLQRKETVKGIQKREARDCITIRHFENKFAVETVICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UN05</accession>
    <name>A0A8C5UN05_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isoamyl acetate-hydrolyzing esterase 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">IAH1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probable lipase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641149.2">
        <property type="nucleotide sequence ID" value="XM_012785695.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UN05"/>
    <dbReference type="Ensembl" id="ENSMICT00000002373.3">
        <property type="protein sequence ID" value="ENSMICP00000002169.3"/>
        <property type="gene ID" value="ENSMICG00000002377.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882941"/>
    <dbReference type="CTD" id="285148"/>
    <dbReference type="GeneTree" id="ENSGT00390000008069"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000002">
        <property type="entry name" value="isoamyl acetate-hydrolyzing esterase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002169.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="249" mass="27563" checksum="66749B01B6EB779D" modified="2022-01-19" version="1">MALSEAVGCGSSLVWPRVLLFGDSITQVSFQQGGWGASLADKLVRKCDVLNRGFSGYNTRWAKIILPRLIRKGNSLDNPVAVTIFFGANDSALKDENPKQHVPLDEYVANLKSMVQYLKSVDVPENRVILVTPPPLCETAWEAECVMQGCKLNRLNSVVGEYANACLQVAQDCGTDVLDLWTLMQKDSQDFSPYLSDGLHLSPKGNEFVFSHLWPLIEKKVSSLPLLLPYWRDVAEAKPELSLLGDGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UND8</accession>
    <name>A0A8C5UND8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inositol polyphosphate 5-phosphatase K</fullName>
            <ecNumber evidence="6">3.1.3.36</ecNumber>
            <ecNumber evidence="5">3.1.3.56</ecNumber>
            <ecNumber evidence="4">3.1.3.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Phosphatidylinositol-4,5-bisphosphate 5-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Skeletal muscle and kidney-enriched inositol phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">INPP5K</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with GPR78; necessary for INPP5K localization at the endoplasmic reticulum. Interacts with PAK1; competes with GPR78.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="6"/>
    <dbReference type="EC" id="3.1.3.56" evidence="5"/>
    <dbReference type="EC" id="3.1.3.86" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03020365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UND8"/>
    <dbReference type="Ensembl" id="ENSMICT00000003861.3">
        <property type="protein sequence ID" value="ENSMICP00000003522.3"/>
        <property type="gene ID" value="ENSMICG00000003861.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156538"/>
    <dbReference type="OMA" id="NSECQHI"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032587">
        <property type="term" value="C:ruffle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016312">
        <property type="term" value="F:inositol bisphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004445">
        <property type="term" value="F:inositol-polyphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034485">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005000">
        <property type="term" value="F:vasopressin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071320">
        <property type="term" value="P:cellular response to cAMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071364">
        <property type="term" value="P:cellular response to epidermal growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032869">
        <property type="term" value="P:cellular response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043922">
        <property type="term" value="P:host-mediated suppression of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051926">
        <property type="term" value="P:negative regulation of calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010829">
        <property type="term" value="P:negative regulation of D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035305">
        <property type="term" value="P:negative regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090315">
        <property type="term" value="P:negative regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045869">
        <property type="term" value="P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001153">
        <property type="term" value="P:positive regulation of renal water transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035810">
        <property type="term" value="P:positive regulation of urine volume"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097178">
        <property type="term" value="P:ruffle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000005">
        <property type="entry name" value="inositol polyphosphate 5-phosphatase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000032">
        <property type="entry name" value="inositol polyphosphate 5-phosphatase K isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041611">
        <property type="entry name" value="SKICH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF117">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17751">
        <property type="entry name" value="SKICH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="17">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005910"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012981"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057102"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063461"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00072639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00082813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003522.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="447" mass="51750" checksum="442C4CF8E8F4CE40" modified="2022-01-19" version="1">VTLRKPTGPKVRKLSIHVVTWNVASAAPPLDLNDLLQLNNQDLNLDICIIGLQEMNSGIINRLSDAAFEDPWSSFFMDVLSPLNLVKVSHVRMQGILLLVFAKYQHLPYIQILFTNSTPTGLFGYWGNKGGVNICLKVYGYYVSIINCHLPPHMSNNDQRLEHFDRILEMQNYERHNIPNILDHDLILWFGDMNFRIEDFGLHFVRESIKKQCYSHLWEKDQLSIAKKHDPLLREFQEGLLLFPPTYKFDRNSNNYDTSEKRRKPAWTDRILWRLKRQSRACSLTPRLPAPYFSLSLRSYVSHMIYRISDHKPVTGTFDLELKPLVSAPLIALMPENLWTMEDNLVVSYSSDPNFPSSPWDWIGLYKVGMRHINDYVSYVWVGDNQISFSDNLVYIDISAIPKTADQCLLCYFSNNLHSVVGISKPFQIPPRFFLKEDALGEAQPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5URZ2</accession>
    <name>A0A8C5URZ2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Interleukin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">IL21</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the IL-15/IL-21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018785">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5URZ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000005314.3">
        <property type="protein sequence ID" value="ENSMICP00000004843.3"/>
        <property type="gene ID" value="ENSMICG00000005315.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010494"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005134">
        <property type="term" value="F:interleukin-2 receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048469">
        <property type="term" value="P:cell maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002314">
        <property type="term" value="P:germinal center B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001779">
        <property type="term" value="P:natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042267">
        <property type="term" value="P:natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002639">
        <property type="term" value="P:positive regulation of immunoglobulin production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032733">
        <property type="term" value="P:positive regulation of interleukin-10 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032740">
        <property type="term" value="P:positive regulation of interleukin-17 production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002729">
        <property type="term" value="P:positive regulation of natural killer cell cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032825">
        <property type="term" value="P:positive regulation of natural killer cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045954">
        <property type="term" value="P:positive regulation of natural killer cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032729">
        <property type="term" value="P:positive regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061470">
        <property type="term" value="P:T follicular helper cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.70:FF:000002">
        <property type="entry name" value="Interleukin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.70">
        <property type="entry name" value="Interleukin-15/Interleukin-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003443">
        <property type="entry name" value="IL-15/IL-21_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356">
        <property type="entry name" value="INTERLEUKIN-15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14356:SF2">
        <property type="entry name" value="INTERLEUKIN-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02372">
        <property type="entry name" value="IL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="4-helical cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034376773" description="Interleukin" evidence="9">
        <location>
            <begin position="30"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004843.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="162" mass="18807" checksum="10E0E222CEE2B183" modified="2022-01-19" version="1">MKSSPGNMERIVTCLMVIFLGTLVHKSSSQDQDRLMIRMRQLIDIVDQLKNYVNVLDTEFLRSPQDVKRHCEWSAFSCFQKARLKSANTGDNEKIISVLIKQLKRKLPPTKAARRQKHKLTCPSCDSYENKPPKEFLERLKSLLQKMIHQHLSPRTQGNENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWE2</accession>
    <name>A0A8C5UWE2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="24">Contactin associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">CNTNAP1</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Paranodal septate junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neurexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012598623.1">
        <property type="nucleotide sequence ID" value="XM_012743169.1"/>
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    <dbReference type="Ensembl" id="ENSMICT00000010316.3">
        <property type="protein sequence ID" value="ENSMICP00000009395.3"/>
        <property type="gene ID" value="ENSMICG00000010313.3"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:axonogenesis"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:central nervous system myelination"/>
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        <property type="term" value="P:cytoskeleton organization"/>
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        <property type="term" value="P:myelination in peripheral nervous system"/>
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        <property type="term" value="P:neuromuscular junction development, skeletal muscle fiber"/>
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        <property type="term" value="P:neuromuscular process controlling balance"/>
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        <property type="term" value="P:neuronal action potential propagation"/>
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        <property type="term" value="P:postsynaptic density organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein localization to juxtaparanode region of axon"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0002175">
        <property type="term" value="P:protein localization to paranode region of axon"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of synapse maturation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LamG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000082">
        <property type="entry name" value="Contactin associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000099">
        <property type="entry name" value="Contactin associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Contactin associated protein-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000016">
        <property type="entry name" value="Contactin-associated protein-like 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000026">
        <property type="entry name" value="contactin-associated protein-like 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000015">
        <property type="entry name" value="neurexin-1 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002181">
        <property type="entry name" value="Fibrinogen_a/b/g_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003585">
        <property type="entry name" value="Neurexin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050372">
        <property type="entry name" value="Neurexin-related_CASP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036:SF43">
        <property type="entry name" value="CONTACTIN-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15036">
        <property type="entry name" value="PIKACHURIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="4.1m"/>
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    </dbReference>
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        <property type="entry name" value="LamG"/>
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    </dbReference>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    </dbReference>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
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    <feature type="chain" id="PRO_5044149910" evidence="19">
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            <begin position="20"/>
            <end position="1382"/>
        </location>
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            <begin position="1281"/>
            <end position="1306"/>
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        <location>
            <begin position="25"/>
            <end position="168"/>
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        <location>
            <begin position="174"/>
            <end position="355"/>
        </location>
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    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="361"/>
            <end position="538"/>
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    </feature>
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        <location>
            <begin position="540"/>
            <end position="577"/>
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    </feature>
    <feature type="domain" description="Fibrinogen C-terminal" evidence="23">
        <location>
            <begin position="576"/>
            <end position="628"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="785"/>
            <end position="957"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="22">
        <location>
            <begin position="958"/>
            <end position="996"/>
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    </feature>
    <feature type="domain" description="Laminin G" evidence="21">
        <location>
            <begin position="1049"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1317"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1318"/>
            <end position="1328"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1330"/>
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    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
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    <evidence type="ECO:0000256" key="1">
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00122"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51406"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009395.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="1382" mass="156049" checksum="559F43C873CA6D27" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UX96</accession>
    <name>A0A8C5UX96_MICMU</name>
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        <submittedName>
            <fullName evidence="21">Adhesion G protein-coupled receptor E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ADGRE1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
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        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
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                <person name="Nguyen L."/>
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                <person name="Quiroz J."/>
                <person name="Raj R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome 18"/>
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    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.20:FF:000001">
        <property type="entry name" value="Alpha-tocopherol transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000002">
        <property type="entry name" value="Alpha-tocopherol transfer protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1200">
        <property type="entry name" value="Alpha-tocopherol transfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF130">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="117"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007524.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="342" mass="38469" checksum="F15C9668C0BF1727" modified="2022-01-19" version="1">MSKESDSLRTSPSVASLSENELSPPPEPPGYVCSLTEELVTKAREELQEKPEWRLRDVQALRDMVRKDYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNYHSCRRSWPEVFDNLKPSALKDVLASGFLTVLPHTDPRGCHVLCLRPDRWIPSNYPITENIRAIYLTLEKLIQSEETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAVHIVNEPRIFKGIFAIIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGGTAGELDTATWNAVLLASEDDFVKEFCQVAPACDSTLGQALLPEGLTSDAQCDDSMRGVKSQLYSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1Y1</accession>
    <name>A0A8C5V1Y1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">THAP domain containing 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">THAP7</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1Y1"/>
    <dbReference type="Ensembl" id="ENSMICT00000014613.3">
        <property type="protein sequence ID" value="ENSMICP00000013322.2"/>
        <property type="gene ID" value="ENSMICG00000014619.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111394"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140296">
        <property type="term" value="F:general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140008">
        <property type="term" value="F:histone H4 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001222">
        <property type="term" value="F:transcription corepressor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026519">
        <property type="entry name" value="THAP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47502">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47502:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="127"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013322.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="309" mass="34432" checksum="253CF2339E675FDA" modified="2022-01-19" version="1">MPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCRRLDPSGQGLWDPASEYIYFCSKHFEENCFELVGISGYHRLKEGAVPTIFESFSKLRRTSKTKGHSYPPGRPDVSRLRQCRKRCSEGRGPTTPFSPPPPADVTCFPVEEASAPATLPASPAGRLEPGLSSPFSDLLGSLGAQADEAGCSAQPSPEQQPSPLEPRPVSPSAYMLRLPPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKAQRQLQACKRREQRLRLRLTKLQQERAREKRAQADARQTLKEHVQDFAMQLSSSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V238</accession>
    <name>A0A8C5V238_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="30">Notch receptor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">NOTCH3</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOTCH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030169">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03030170">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000014235.3">
        <property type="protein sequence ID" value="ENSMICP00000012977.3"/>
        <property type="gene ID" value="ENSMICG00000014208.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160234"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048646">
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                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636742.1">
        <property type="nucleotide sequence ID" value="XM_012781288.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V748"/>
    <dbReference type="Ensembl" id="ENSMICT00000016630.3">
        <property type="protein sequence ID" value="ENSMICP00000015153.3"/>
        <property type="gene ID" value="ENSMICG00000016636.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880330"/>
    <dbReference type="KEGG" id="mmur:105880330"/>
    <dbReference type="CTD" id="90187"/>
    <dbReference type="GeneTree" id="ENSGT01030000234633"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1490:FF:000037">
        <property type="entry name" value="Elastin microfibril interfacer 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011489">
        <property type="entry name" value="EMI_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF2">
        <property type="entry name" value="EMILIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07546">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51041">
        <property type="entry name" value="EMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149990" evidence="7">
        <location>
            <begin position="23"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="EMI" evidence="8">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015153.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="760" mass="82389" checksum="40A28DE6312E7E6B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7W4</accession>
    <name>A0A8C5V7W4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Putative ATP-dependent RNA helicase DHX57</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DEAH box protein 57</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">DHX57</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Probable ATP-binding RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03011857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011858">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000049816.2">
        <property type="protein sequence ID" value="ENSMICP00000017467.2"/>
        <property type="gene ID" value="ENSMICG00000028350.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156883"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17985">
        <property type="entry name" value="DEXHc_DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23825">
        <property type="entry name" value="RWD_DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14317">
        <property type="entry name" value="UBA_DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000325">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000284">
        <property type="entry name" value="probable ATP-dependent RNA helicase YTHDC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000038">
        <property type="entry name" value="putative ATP-dependent RNA helicase DHX57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042615">
        <property type="entry name" value="DHX57_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF145">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX57-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBA" evidence="17">
        <location>
            <begin position="179"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="18">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="559"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="835"/>
            <end position="1015"/>
        </location>
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    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00071682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083389"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017467.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1391" mass="156134" checksum="6413822E28C4DAE6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V8E7</accession>
    <name>A0A8C5V8E7_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Activator of HSP90 ATPase homolog 2, pseudo</fullName>
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        <name evidence="3" type="primary">AHSA2</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the AHA1 family.</text>
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</entry>
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            <taxon>Primates</taxon>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="ENSMICG00000001261.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000001505"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040235">
        <property type="entry name" value="Nicolin-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31239">
        <property type="entry name" value="NICOLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31239:SF2">
        <property type="entry name" value="NICOLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="213" mass="24205" checksum="E36F374AB59A2C1D" modified="2022-01-19" version="1">MSRVSVPCHVKGTVALQVGDVRTSHGRPGVLVIDVTFPSVAPFELQEITFKNYYTAFLSIRVRQHTSMHTPAKWVTCLRDHCLMPNPHSEEGAQDYVSLFKHQMLCDMARVLELRLILRQPSPLWLSFTVEELQIYQQGPKSPSMTFPKWLSHPVPCEQPVPLLEGLPDPSRVSSEVQQMWALTEMIRASHTSARIGRFDVDGCYDLNLLSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCJ3</accession>
    <name>A0A8C5VCJ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Deoxyribonuclease-2-beta</fullName>
            <ecNumber evidence="4">3.1.22.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">DNase II-like acid DNase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">DNase2-like acid DNase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Deoxyribonuclease II beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Endonuclease DLAD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DNASE2B</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.22.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the DNase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.1" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03002715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603032.1">
        <property type="nucleotide sequence ID" value="XM_012747578.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VCJ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000035256.2">
        <property type="protein sequence ID" value="ENSMICP00000019901.1"/>
        <property type="gene ID" value="ENSMICG00000037013.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105861794"/>
    <dbReference type="CTD" id="58511"/>
    <dbReference type="GeneTree" id="ENSGT00390000002634"/>
    <dbReference type="OrthoDB" id="9519604at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004531">
        <property type="term" value="F:deoxyribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004947">
        <property type="entry name" value="DNase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858">
        <property type="entry name" value="DEOXYRIBONUCLEASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10858:SF2">
        <property type="entry name" value="DEOXYRIBONUCLEASE-2-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03265">
        <property type="entry name" value="DNase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0458">Lysosome</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150042" description="Deoxyribonuclease-2-beta" evidence="5">
        <location>
            <begin position="24"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="360" mass="41431" checksum="40D591CA182B6A2E" modified="2022-01-19" version="1">MTARLLKTPLALLFLALFEVLEATKISCRNEEGKAVDWFTFYKLPIQVKRQKKESKGSGLEYLYLDSTTRSWRRSKQPMNTTKSVLGRTLHQLYEAYASKNNNTAYLIYNDGVPKTVTYSTKYGHTKGVMLWNRVQGFWLIHSIPRFPPIPEEGYDYPPTGRRNGQSGICITLKYNQYEAIDSQLLVCNPNIYSCSIPATFHQKLVHIFQLCTRSSSSKIPGRHLTRLQSVQGENFLHFAKSNSFLDDIFAAWMAPQLKTHLLTETWQRTGQDLPSNCSLPYHVYNIKAIKLSQQTYFNSSQDHSKWCISQKGTKNHWTCIGDINRSASQAFRSGGFICTQNRHIYQAFQGLVLYYEKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VG12</accession>
    <name>A0A8C5VG12_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">vitamin-K-epoxide reductase (warfarin-sensitive)</fullName>
            <ecNumber evidence="3">1.17.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">VKORC1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:57744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <dbReference type="ChEBI" id="CHEBI:28433"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.17.4.4"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:57746"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>phylloquinone + [protein]-disulfide + H2O = 2,3-epoxyphylloquinone + [protein]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:10593"/>
            <dbReference type="Rhea" id="RHEA-COMP:10594"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15759"/>
            <dbReference type="ChEBI" id="CHEBI:18067"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.17.4.4"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:13819"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VKOR family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.4" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03021375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619617.1">
        <property type="nucleotide sequence ID" value="XM_012764163.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VG12"/>
    <dbReference type="Ensembl" id="ENSMICT00000053126.2">
        <property type="protein sequence ID" value="ENSMICP00000022364.1"/>
        <property type="gene ID" value="ENSMICG00000042552.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105871049"/>
    <dbReference type="KEGG" id="mmur:105871049"/>
    <dbReference type="CTD" id="79001"/>
    <dbReference type="GeneTree" id="ENSGT00940000157421"/>
    <dbReference type="OrthoDB" id="9006044at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047058">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-insensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047057">
        <property type="term" value="F:vitamin-K-epoxide reductase (warfarin-sensitive) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050820">
        <property type="term" value="P:positive regulation of coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042373">
        <property type="term" value="P:vitamin K metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12917">
        <property type="entry name" value="VKOR_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.130:FF:000001">
        <property type="entry name" value="Vitamin K epoxide reductase complex subunit 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.130">
        <property type="entry name" value="VKOR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012932">
        <property type="entry name" value="VKOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038354">
        <property type="entry name" value="VKOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042406">
        <property type="entry name" value="VKORC1/VKORC1L1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519:SF8">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14519">
        <property type="entry name" value="VITAMIN K EPOXIDE REDUCTASE COMPLEX, SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07884">
        <property type="entry name" value="VKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00756">
        <property type="entry name" value="VKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="11" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Vitamin K epoxide reductase" evidence="15">
        <location>
            <begin position="5"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="163" mass="18059" checksum="720A8D3D1743A2AD" modified="2022-01-19" version="1">MGTTWGSPGWVRLALCLAGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSVLNQSNSIYGCLFYTLQLLLGCLRGRWASILLVLSSLVSLAGSVYLAWILFFVLYDFCVVCITTYAINVGLMLLSFRRVQKSQDKIKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VL52</accession>
    <name>A0A8C5VL52_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC105864204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VL52"/>
    <dbReference type="Ensembl" id="ENSMICT00000050354.2">
        <property type="protein sequence ID" value="ENSMICP00000021884.1"/>
        <property type="gene ID" value="ENSMICG00000027330.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064266"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026245">
        <property type="entry name" value="FRG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31883:SF1">
        <property type="entry name" value="PROTEIN FRG2-LIKE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31883">
        <property type="entry name" value="PROTEIN FRG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15315">
        <property type="entry name" value="FRG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02074">
        <property type="entry name" value="PROTEINFRG2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="285" mass="31590" checksum="178B904F7D8D520E" modified="2022-01-19" version="1">MGLGTEDQEPQSPSSQCQTGQPPFKQISFPERDSDEEKKPFEEVGKALAAHSSENHKTQGQESEPNPNEGENSNETKPKARNGTAKPESEASSGARNSRKRKISCKDSCQDRAGNCLEDEHSLTLGKKPKTSAAVHSNEMEDTHNAKHRGHPKAHTEHNKWPRSRFSRDHPPPLRKSLVDSLRAMSEAVYQDLAQVWAQQVHSPLTWEQLSELTQLQGPLCTMVQTFYAMATQAAYVFPAEDWLTPATLPGPGGPALDGEAHRRHVRHLPRQETTKPVSGSDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMD6</accession>
    <name>A0A8C5VMD6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribose-phosphate diphosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03008313">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMD6"/>
    <dbReference type="Ensembl" id="ENSMICT00000046802.2">
        <property type="protein sequence ID" value="ENSMICP00000025227.1"/>
        <property type="gene ID" value="ENSMICG00000029426.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182803"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000005">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF118">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="11">
        <location>
            <begin position="5"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="291" mass="31797" checksum="1F2997A2D8395F59" modified="2022-01-19" version="1">MLNTKIVSGSSHQDLSQKITDCLSLELGEVVTEKFSNQETCVEILYGEDVYIVQSGCGEINDNLMELLIMINASSRVTAVFPCFLYARQIRKDKGWAPISAKLVANKLSVAVADHIIAMDLHASQMQEAAVLEWIRENLSEWRNCTVVSPDAGGAKRVTSAADRLNVDFALIHKERKKASEVDRMVLVGNVKDRVAVLVDDIADACGTICHAADKRLSAGATTVYAILTHGIFAGPAISPVVVTNTIPQEDKMKHCSKIQVTDISMILAEAISRTHNGEFVSYLFSHVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VN22</accession>
    <name>A0A8C5VN22_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Nuclear factor of activated T cells 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">NFATC4</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012756072.1"/>
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        <property type="protein sequence ID" value="ENSMICP00000026451.2"/>
        <property type="gene ID" value="ENSMICG00000014210.3"/>
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        <property type="protein sequence ID" value="ENSMICP00000027001.2"/>
        <property type="gene ID" value="ENSMICG00000014210.3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="IPT_NFAT"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Rel homology domain (RHD), DNA-binding domain"/>
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    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
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            <end position="578"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <end position="176"/>
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            <end position="865"/>
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            <begin position="1"/>
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            <begin position="51"/>
            <end position="77"/>
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            <end position="105"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNH9</accession>
    <name>A0A8C5VNH9_MICMU</name>
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            <fullName evidence="10">Methionine N-acetyltransferase</fullName>
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        <alternativeName>
            <fullName evidence="7">N-acetyltransferase 5</fullName>
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            <fullName evidence="11">N-terminal acetyltransferase B complex catalytic subunit NAA20</fullName>
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        <alternativeName>
            <fullName evidence="9">N-terminal acetyltransferase B complex catalytic subunit NAT5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">NatB catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50484"/>
            <dbReference type="Rhea" id="RHEA-COMP:12694"/>
            <dbReference type="Rhea" id="RHEA-COMP:12695"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133356"/>
            <dbReference type="ChEBI" id="CHEBI:133358"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50480"/>
            <dbReference type="Rhea" id="RHEA-COMP:12692"/>
            <dbReference type="Rhea" id="RHEA-COMP:12693"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133045"/>
            <dbReference type="ChEBI" id="CHEBI:133063"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50492"/>
            <dbReference type="Rhea" id="RHEA-COMP:12698"/>
            <dbReference type="Rhea" id="RHEA-COMP:12699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133361"/>
            <dbReference type="ChEBI" id="CHEBI:133362"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50488"/>
            <dbReference type="Rhea" id="RHEA-COMP:12696"/>
            <dbReference type="Rhea" id="RHEA-COMP:12697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133359"/>
            <dbReference type="ChEBI" id="CHEBI:133360"/>
            <dbReference type="EC" id="2.3.1.254"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.254" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03006508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNH9"/>
    <dbReference type="Ensembl" id="ENSMICT00000028500.2">
        <property type="protein sequence ID" value="ENSMICP00000025861.2"/>
        <property type="gene ID" value="ENSMICG00000037420.2"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
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    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
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    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
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    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
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    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
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        <source>
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            <dbReference type="Ensembl" id="ENSMICP00000025861.2"/>
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    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="156" mass="17963" checksum="58901F5A057A6245" modified="2022-01-19" version="1">MLKTYGIPFYLWYLAHWPEYFIVAEAPGGELMGYIMGKAEGSVAREEWHRHITALSAAPEFQCLGLAAKIMELLEEISERKSGFFVDLFVRVSNQVAVNMYKQLGYSVHRTVIEYYSASNREPDEDAYDMRKALSRDTEKKSIIPLPHPVRPEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNM0</accession>
    <name>A0A8C5VNM0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Adhesion G-protein coupled receptor F2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ADGRF2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600255.1">
        <property type="nucleotide sequence ID" value="XM_012744801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNM0"/>
    <dbReference type="Ensembl" id="ENSMICT00000045881.2">
        <property type="protein sequence ID" value="ENSMICP00000026741.1"/>
        <property type="gene ID" value="ENSMICG00000033055.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105860251"/>
    <dbReference type="GeneTree" id="ENSGT00940000162401"/>
    <dbReference type="OrthoDB" id="10040049at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15994">
        <property type="entry name" value="7tmB2_GPR111_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.220.50:FF:000015">
        <property type="entry name" value="Adhesion G protein-coupled receptor F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000058">
        <property type="entry name" value="Adhesion G protein-coupled receptor F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051587">
        <property type="entry name" value="Adhesion_GPCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008078">
        <property type="entry name" value="GPCR_2_Ig-hepta-like_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813:SF6">
        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45813">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01825">
        <property type="entry name" value="GPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01695">
        <property type="entry name" value="IGHEPTARCPTR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50221">
        <property type="entry name" value="GAIN_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150105" description="Adhesion G-protein coupled receptor F2" evidence="10">
        <location>
            <begin position="19"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="11">
        <location>
            <begin position="227"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="12">
        <location>
            <begin position="378"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="73952" checksum="33A6EEE3F5924F24" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQJ3</accession>
    <name>A0A8C5VQJ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CDGSH iron-sulfur domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Mitochondrion outer membrane</location>
            <topology evidence="12">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the CISD protein family. CISD2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033640">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQJ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000054336.2">
        <property type="protein sequence ID" value="ENSMICP00000024365.2"/>
        <property type="gene ID" value="ENSMICG00000035347.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156660"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.5.90:FF:000001">
        <property type="entry name" value="CDGSH iron-sulfur domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.90">
        <property type="entry name" value="CDGSH iron-sulfur domain, mitoNEET-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045131">
        <property type="entry name" value="CISD1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018967">
        <property type="entry name" value="FeS-contain_CDGSH-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019610">
        <property type="entry name" value="FeS-contain_mitoNEET_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042216">
        <property type="entry name" value="MitoNEET_CISD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13680:SF33">
        <property type="entry name" value="CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10660">
        <property type="entry name" value="MitoNEET_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09360">
        <property type="entry name" value="zf-CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00704">
        <property type="entry name" value="ZnF_CDGSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Iron-binding zinc finger CDGSH type" evidence="13">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024365.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="130" mass="14558" checksum="85D259AA1A375EC3" modified="2022-01-19" version="1">VLESVAHAVKVQLSEYLKQLPVPESIICTGHMETISEWLRLLSFLGVLALLGYLAGKKTQQKDSLINLKIQKENPKVVNEINIEDLCLTKADYCRCWHSKMFPACDDSHSKHSELTGGDVGPLILKKKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQV3</accession>
    <name>A0A8C5VQV3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protocadherin beta 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PCDHB14</name>
        <name evidence="16" type="synonym">LOC105862572</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022496">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQV3"/>
    <dbReference type="Ensembl" id="ENSMICT00000034806.2">
        <property type="protein sequence ID" value="ENSMICP00000027182.2"/>
        <property type="gene ID" value="ENSMICG00000035051.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163362"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000004">
        <property type="entry name" value="Protocadherin 1 gamma 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000002">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000006">
        <property type="entry name" value="Protocadherin alpha 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000309">
        <property type="entry name" value="Protocadherin beta-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000018">
        <property type="entry name" value="Protocadherin gamma c3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032455">
        <property type="entry name" value="Cadherin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF81">
        <property type="entry name" value="PROTOCADHERIN BETA-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16492">
        <property type="entry name" value="Cadherin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034893103" evidence="14">
        <location>
            <begin position="27"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="676"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="134"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="243"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="348"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="504"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="15">
        <location>
            <begin position="577"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027182.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="786" mass="86318" checksum="C75DFC7621BBFC3F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VRQ9</accession>
    <name>A0A8C5VRQ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-dependent oxidoreductase domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">FOXRED1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="16">Associates with components of the mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007216">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRQ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000037309.2">
        <property type="protein sequence ID" value="ENSMICP00000026496.2"/>
        <property type="gene ID" value="ENSMICG00000036801.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006114"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000155">
        <property type="entry name" value="FAD-dependent oxidoreductase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF287">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="65"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026496.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="486" mass="53881" checksum="94512E39022DE262" modified="2022-01-19" version="1">MLRRVLRLASGRALVARALSTRRGGSTPDRDGKVSEIKKKIQSILPGEPWNPLYDTSHLPPERSDVVIVGGGVLGLSVAYWLKKLENRRGAIQVLVVERDHTYSQASTALSIGGIRQQFSLPENIQLSLFSANFLRNINEYLAVVDAPPLDLQFNPLGYLLLASEKGAATMESNVKVQRQEGAKVCLMSPEQLQNKFPWINTKGVALASYGMENEGWFDPWCLLQGLRRKVQSMGVLFCQGEVTRFISSSSHMKTTSGKEVTLKRIYEVHVKMDHSMEYQPVECALVINAAGAWSGQVAELAGIGKGPPGTLQGTRLPVEPRKRYVYLWHCPQGPGLEAPLVTDMSGAYFRREGLGNNYLGGLSPIEEEEPDPGNLEVDYDFFQDKVWPPLAQRVPAFETLKVRSAWAGYYDYNTFDQNGVVGPHPLVVNMYFAAGFSGHGLQQAPGVGRAVAEMVLEGHFQTIDLSPFLFSRFYLGEKIQEHVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VRR9</accession>
    <name>A0A8C5VRR9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Initiation factor 2-associated 67 kDa glycoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
            <shortName evidence="8">p67</shortName>
            <shortName evidence="8">p67eIF2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105860182</name>
        <name evidence="8" type="synonym">METAP2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="function">
        <text evidence="8">Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">About 30% of expressed METAP2 associates with polysomes.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03015204">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRR9"/>
    <dbReference type="Ensembl" id="ENSMICT00000028172.2">
        <property type="protein sequence ID" value="ENSMICP00000028802.2"/>
        <property type="gene ID" value="ENSMICG00000027575.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155016"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="10">
        <location>
            <begin position="142"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
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    <feature type="binding site" evidence="8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
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        <location>
            <position position="385"/>
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        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028802.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="404" mass="46022" checksum="A84A49C6B8D26F4C" modified="2022-01-19" version="1">MAGVEEAAASGSHLNGDLDLDNRERELPLWLRKQPRKKDGRRRVKGLLQQLERQALEEKERDNDDECGDGTTGKKKKKKKRGPKAQTDLPSVPIYDLYPNVFPKGQEYEYPPTQDGQTAAWRITSEEKRALDQASEEIWNDFQEAGEAHQQVRKYVMSWIKPGMTMIEISEKLEDCSRKLIKENGLNAGLAFPTGLLQYDDICKIDFRTHISSRIIDCAFTITFNPKYDTLLKAVKDATNTGIKCARIDVRLCDVGEAIQEVMESYEVEIDGMTYQVKPIHNLNGHSIGQYRIHAGKTVSIVKGRETTRMEEGEVYAIETFDSTGRGVVHDDMKNFGTLAFCCRWLDHLGESKYLMALKNLCDLDIVDPYPPLCDIKESYKAQFEHTILLRPTCKEVVSRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VSK1</accession>
    <name>A0A8C5VSK1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serpin B8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">SERPINB8</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="11">Liver</tissue>
        </source>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Has an important role in epithelial desmosome-mediated cell-cell adhesion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serpin family. Ov-serpin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629913.1">
        <property type="nucleotide sequence ID" value="XM_012774459.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VSK1"/>
    <dbReference type="Ensembl" id="ENSMICT00000031114.2">
        <property type="protein sequence ID" value="ENSMICP00000026939.1"/>
        <property type="gene ID" value="ENSMICG00000016522.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876719"/>
    <dbReference type="KEGG" id="mmur:105876719"/>
    <dbReference type="CTD" id="5271"/>
    <dbReference type="GeneTree" id="ENSGT00940000154835"/>
    <dbReference type="OrthoDB" id="671595at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090136">
        <property type="term" value="P:epithelial cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.310.10:FF:000001">
        <property type="entry name" value="Serpin family A member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.497.10:FF:000018">
        <property type="entry name" value="Serpin family B member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.39.10:FF:000014">
        <property type="entry name" value="Serpin family B member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="entry name" value="Alpha-1-antitrypsin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="entry name" value="Antithrombin, subunit I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461:SF166">
        <property type="entry name" value="SERPIN B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="Serpins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0722">Serine protease inhibitor</keyword>
    <feature type="domain" description="Serpin" evidence="8">
        <location>
            <begin position="14"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="RefSeq" id="XP_012629913.1"/>
        </source>
    </evidence>
    <sequence length="375" mass="42831" checksum="4F076B39C5E0D4C0" modified="2022-01-19" version="1">MMDDICEANGTFAINLFKMLGEEDNCRNVFFSPLSVTSALAMVLLGAEGNTAAQMSQALCLNEDEDVHQGFQSLLSEVNKTGTQYSLRIANRLFGEKTCDFLPTFKESCQKFYQAELEELSFAKDTEECRKHINDWVTERTEGKISEVLAAGTVDSLTKLVLVNAIYFKGKWNEQFDSKYTRGMLFRTKKEKKTVQMMFKQAKFKMGYIEEVHTQVLELPYTEEELSMVILLPDEDTDLAVVEETLTYEKFRAWTNPEKMTKSKVQVFLPRLKLEESYDLESYLRSLGMIDAFEEAKADFSGMSTKKNVPVSKVAHKCFVEVNEEGTEAAAATAVVRNSRCSRPEPRFCVDHPFLFFIRHHKTNSILFCGRFCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VXL7</accession>
    <name>A0A8C5VXL7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-hydroxytryptamine receptor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serotonin receptor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">HTR4</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. HTR4 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts (via C-terminus 330-346 AA) with GRK5; this interaction is promoted by 5-HT (serotonin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597054.1">
        <property type="nucleotide sequence ID" value="XM_012741600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VXL7"/>
    <dbReference type="Ensembl" id="ENSMICT00000051354.2">
        <property type="protein sequence ID" value="ENSMICP00000032282.1"/>
        <property type="gene ID" value="ENSMICG00000002566.3"/>
    </dbReference>
    <dbReference type="CTD" id="3360"/>
    <dbReference type="GeneTree" id="ENSGT00940000155983"/>
    <dbReference type="OrthoDB" id="5859976at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004993">
        <property type="term" value="F:G protein-coupled serotonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071880">
        <property type="term" value="P:adenylate cyclase-activating adrenergic receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032098">
        <property type="term" value="P:regulation of appetite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15056">
        <property type="entry name" value="7tmA_5-HT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000046">
        <property type="entry name" value="5-hydroxytryptamine receptor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001520">
        <property type="entry name" value="5HT4_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248">
        <property type="entry name" value="ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24248:SF66">
        <property type="entry name" value="OCTOPAMINE RECEPTOR BETA-3R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01059">
        <property type="entry name" value="5HT4RECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="36"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="378" mass="42793" checksum="AC4A508CC4AD9165" modified="2022-01-19" version="1">MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWIIPTFISFLPIMQGWNNIGIIDLIEKRKFNHNSNSTYCIFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQMLQRAGAHSEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLSGCSSVSSFLLLFCNRPVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1K0</accession>
    <name>A0A8C5W1K0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitoferrin-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mitochondrial iron transporter 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Solute carrier family 25 member 37</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC25A37</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Fe(2+)(in) = Fe(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28486"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023711">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594806.1">
        <property type="nucleotide sequence ID" value="XM_012739352.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1K0"/>
    <dbReference type="Ensembl" id="ENSMICT00000033610.2">
        <property type="protein sequence ID" value="ENSMICP00000031689.1"/>
        <property type="gene ID" value="ENSMICG00000034841.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105857171"/>
    <dbReference type="KEGG" id="mmur:105857171"/>
    <dbReference type="CTD" id="51312"/>
    <dbReference type="GeneTree" id="ENSGT00940000158607"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046985">
        <property type="term" value="P:positive regulation of hemoglobin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000027">
        <property type="entry name" value="mitoferrin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000031">
        <property type="entry name" value="mitoferrin-2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 19" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="141"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="18">
        <location>
            <begin position="232"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="338" mass="37210" checksum="EC366FEBC612E0A5" modified="2022-01-19" version="1">MELRSGGVGSQAVGCRMDGDGRDGGGGKDAAGPEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLNPDPKAQYTSIYGALKKIMRTEGFWRPLRGLNVMMMGAGPAHAMYFACYENMKRTLNDVFNHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSALSCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRGYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENMALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKHQLENRTPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W5E1</accession>
    <name>A0A8C5W5E1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterogeneous nuclear ribonucleoprotein K</fullName>
        </recommendedName>
    </protein>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Podosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027229">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027230">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5E1"/>
    <dbReference type="Ensembl" id="ENSMICT00000030780.2">
        <property type="protein sequence ID" value="ENSMICP00000037273.2"/>
        <property type="gene ID" value="ENSMICG00000038026.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153434"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22432">
        <property type="entry name" value="KH-I_HNRNPK_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22434">
        <property type="entry name" value="KH-I_HNRNPK_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000021">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein K, like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000025">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein K, like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012987">
        <property type="entry name" value="ROK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08067">
        <property type="entry name" value="ROKNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="19" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12 21" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="16" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="K Homology" evidence="23">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="23">
        <location>
            <begin position="318"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037273.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="396" mass="43482" checksum="DCF2A0AEA215267A" modified="2022-01-19" version="1">METEQPEEIFPNTETNGEFGKGPAEDMEEEQAFKRSRNTDEMVELCILLQSKNAGAVIGKGGKNIKALRTDCNARVSVPDCSGPERILSISADTETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECAKIKELRENTQTTIRVALFFLRQRKPDRVVECIKIILDLISESPVKGHAQPYEPNIYDETYDYGGFTMMFGDRRGRPVGFPIMPPGRGGMPPGRECLLVGVGIPTPPSRRDYDDMSPRRGPPPPPPGGGLMAYDRRGRPEDRYDGMVGFNTRSPSEWQMAYEPQGGSGYDYSYVGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIHHELGASIKIGEPLEGSEDRIITIIGTQDQVQNAQYLLQNSVKQDYSGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8C5W5J1_MICMU</name>
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        <submittedName>
            <fullName evidence="3">RAD51 associated protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">RAD51AP2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03012008">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5J1"/>
    <dbReference type="Ensembl" id="ENSMICT00000054736.2">
        <property type="protein sequence ID" value="ENSMICP00000033610.1"/>
        <property type="gene ID" value="ENSMICG00000038023.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00470000042500"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="RAD51-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031419">
        <property type="entry name" value="RAD51_interact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39229">
        <property type="entry name" value="MCG1037962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39229:SF1">
        <property type="entry name" value="RAD51-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15696">
        <property type="entry name" value="RAD51_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAD51 interacting motif" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1141" mass="131591" checksum="F2ED9E7551FCD74D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W7I0</accession>
    <name>A0A8C5W7I0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ARCN1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11 12">Cytoplasmic vesicle</location>
            <location evidence="11 12">COPI-coated vesicle membrane</location>
            <topology evidence="11 12">Peripheral membrane protein</topology>
            <orientation evidence="11 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11 12">Golgi apparatus membrane</location>
            <topology evidence="11 12">Peripheral membrane protein</topology>
            <orientation evidence="11 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012773610.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5W7I0"/>
    <dbReference type="Ensembl" id="ENSMICT00000011434.3">
        <property type="protein sequence ID" value="ENSMICP00000010408.2"/>
        <property type="gene ID" value="ENSMICG00000011426.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000034325.2">
        <property type="protein sequence ID" value="ENSMICP00000036725.2"/>
        <property type="gene ID" value="ENSMICG00000011426.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876045"/>
    <dbReference type="KEGG" id="mmur:105876045"/>
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    <dbReference type="GeneTree" id="ENSGT00390000017207"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008344">
        <property type="term" value="P:adult locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021691">
        <property type="term" value="P:cerebellar Purkinje cell layer maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043473">
        <property type="term" value="P:pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1170:FF:000007">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="14">
        <location>
            <begin position="271"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036725.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="511" mass="57177" checksum="F690F48A6F9EBB0E" modified="2022-01-19" version="1">MVLLAAAVCTKAGKAIVSRQFVEMTRTRIEGLLAAFPKLMNTGKQHTFVETESVRYVYQPMEKLYMVLITTKNSNILEDLETLRLFSRVIPEYCRALEENEISEHCFDLIFAFDEIVALGYRENVNLAQIRTFTEMDSHEEKVFRAVRETQEREAKAEMRRKAKELQQARRDAERQGKKAPGFGGFGSSAVSGGSTAAMITETIIETDKPKVAPAPARPSGPSKALKLGAKGKEVDNFVDKLKSEGETIMSSNMGKRTSEATKVHAAPINMESVHMKIEEKITLTCGRDGGLQNMELHGMIMLRISDDKFGRIRLHVENEDKKGVQLQTHPNVDKKLFTAESLIGLKNPEKSFPVNSDVGVLKWRLQTTEESFIPLTINCWPSESGNGCDVNIEYELQEDNLELNDVVITIPLPSGVGAPVIGEIDGEYRHDSRRNTLEWCLPVIDAKNKSGSLEFSIAGQPNDFFPVQVSFISKKNYCNIQVTKVTQVDGNSPVRFSTETTFLVDKYEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W7P1</accession>
    <name>A0A8C5W7P1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ganglioside GM2 activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">GM2A</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W7P1"/>
    <dbReference type="Ensembl" id="ENSMICT00000042639.2">
        <property type="protein sequence ID" value="ENSMICP00000035402.1"/>
        <property type="gene ID" value="ENSMICG00000031216.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105858023"/>
    <dbReference type="GeneTree" id="ENSGT00390000003288"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007611">
        <property type="term" value="P:learning or memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019915">
        <property type="term" value="P:lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.220.10">
        <property type="entry name" value="Ganglioside GM2 activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028996">
        <property type="entry name" value="GM2-AP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036846">
        <property type="entry name" value="GM2-AP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357:SF0">
        <property type="entry name" value="GANGLIOSIDE GM2 ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17357">
        <property type="entry name" value="GM2 GANGLIOSIDE ACTIVATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63707">
        <property type="entry name" value="Ganglioside M2 (gm2) activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034175725" evidence="2">
        <location>
            <begin position="31"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="3">
        <location>
            <begin position="43"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="200" mass="21267" checksum="D938F408CA8DCF49" modified="2022-01-19" version="1">MQPLLQAPSPPPLLLLLLALGLLLAGPAAPASVHLKQLGSFSWDNCDEGKDPAVIKSLTLEPDPIVVPGNVTISAKGQTSVALSSPLKVELTVEKEVAGFWVKIPCVEQIGSCTYDDFCNVLDTFIPPGNPCPEPLHTYGLPCHCPFKDGTYSLPKSDFTMPDLELPGWLSTGNYRIQSILSSSGTRLACVKIAASLKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W829</accession>
    <name>A0A8C5W829_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LOC105861317</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602163.1">
        <property type="nucleotide sequence ID" value="XM_012746709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W829"/>
    <dbReference type="Ensembl" id="ENSMICT00000049652.2">
        <property type="protein sequence ID" value="ENSMICP00000033861.2"/>
        <property type="gene ID" value="ENSMICG00000043848.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105861317"/>
    <dbReference type="KEGG" id="mmur:105861317"/>
    <dbReference type="GeneTree" id="ENSGT01140000282514"/>
    <dbReference type="OrthoDB" id="9448403at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15410">
        <property type="entry name" value="7tmA_OR5D-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033861.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="311" mass="34473" checksum="FA02A4A85BDDD6C2" modified="2022-01-19" version="1">MDKENCTTMTEFILLGLSDAPELQVLLPLMFLLIYGVTVLANLGMTALIHVSSGLHTPMYFFLSHLSFIDFCYSSIIVPKMLANILNQNKSISFLGCMMQFYLFGSSVITEIFLLAVMAYDRFVAICNPLLYMVTMSQKLCVGLASCCYFCGTLCSLIHLCLALEIPSYRSNVINHFFCDLPPLLSLACSDVTVNEVLLFIVATVNEISTIVIILTSYLFIVITILRMRSAEGRRKAFSTCASHLTAIVVFHGTILSIYCRPSSGTSGDADKVATVFYTVVIPMLNPLIYSLRNKDVKEALRKVLGSKVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XB67</accession>
    <name>A0A8C5XB67_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Amine oxidase</fullName>
            <ecNumber evidence="26">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">MAOA</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:51168"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:71406"/>
            <dbReference type="ChEBI" id="CHEBI:180943"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:69076"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:72587"/>
            <dbReference type="ChEBI" id="CHEBI:180943"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:25265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16424"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:225237"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27946"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:27978"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:59905"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>kynuramine + O2 + H2O = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:180898"/>
            <dbReference type="ChEBI" id="CHEBI:180899"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:59597"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>serotonin + O2 + H2O = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:69072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:50157"/>
            <dbReference type="ChEBI" id="CHEBI:350546"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>tryptamine + O2 + H2O = indole-3-acetaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:59416"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18086"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57887"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:30591"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15621"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:327995"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 26">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="26"/>
    <dbReference type="EMBL" id="ABDC03036476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XB67"/>
    <dbReference type="Ensembl" id="ENSMICT00000002042.3">
        <property type="protein sequence ID" value="ENSMICP00000001868.2"/>
        <property type="gene ID" value="ENSMICG00000002042.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160514"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042420">
        <property type="term" value="P:dopamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009967">
        <property type="term" value="P:positive regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF11">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="7 26" id="KW-0274">FAD</keyword>
    <keyword evidence="4 26" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0531">Neurotransmitter degradation</keyword>
    <keyword evidence="11 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Amine oxidase" evidence="27">
        <location>
            <begin position="23"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="43"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001868.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="527" mass="59820" checksum="493744010943E412" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XD62</accession>
    <name>A0A8C5XD62_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coenzyme Q8B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ8B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026934">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026935">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XD62"/>
    <dbReference type="Ensembl" id="ENSMICT00000009746.3">
        <property type="protein sequence ID" value="ENSMICP00000008875.3"/>
        <property type="gene ID" value="ENSMICG00000009742.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158965"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021692">
        <property type="term" value="P:cerebellar Purkinje cell layer morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF4">
        <property type="entry name" value="ATYPICAL KINASE COQ8B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="7">
        <location>
            <begin position="139"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008875.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="498" mass="56034" checksum="5E1206D0CEBC5179" modified="2022-01-19" version="1">MWLKVGGLLRGTRGQQGQIVGLPCGTLGPGAHWWGPCGGSWAQKFHQDGPGRGLGEEDIRRARETRLSKTPRPQLSDRSRERKVPASRISRLANFGGRLNLRYSHRAPPFLLPHCSPHPAVSQDNSFISPQLQRIFERVRQSADFMPRWQMLRVLEEELGTDWQAKVASLEEVPFAAASIGQVHQGVLRDGTEVAVKIQYPGVAQSIQSDVQNLLAVLKMSVALPEGLFAEQSLQALQQELAWECDYRREAACAQSFRQLLADDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQDIRNQICFQLLRLCLRELFEFRFMQTDPNWANFLYDASSHQVTLLDFGASREFGTEFTDHYIEVVKAAAEGDRDRVLQKSRDLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGAGDTARRIQGLIPVLLQHRLRPPPEETYALHRKLAGAFLACARLRAHIACRDLFQDTYNRYWANRQTQPLTRGDLRADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XE81</accession>
    <name>A0A8C5XE81_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Plexin-B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PLXNB1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018184">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000013904.3">
        <property type="protein sequence ID" value="ENSMICP00000012681.3"/>
        <property type="gene ID" value="ENSMICG00000013880.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286928"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002116">
        <property type="term" value="C:semaphorin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032794">
        <property type="term" value="F:GTPase activating protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017154">
        <property type="term" value="F:semaphorin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904862">
        <property type="term" value="P:inhibitory synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
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        <property type="entry name" value="Immunoglobulins"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <location>
            <begin position="1"/>
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    <sequence length="2135" mass="232384" checksum="FC7C448AC803C011" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGB0</accession>
    <name>A0A8C5XGB0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/arginine-rich splicing factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Pre-mRNA-splicing factor SRP20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Splicing factor, arginine/serine-rich 3</fullName>
        </alternativeName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013537">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ENSMICP00000019439.2"/>
        <property type="gene ID" value="ENSMICG00000037691.2"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000352">
        <property type="entry name" value="Putative serine/arginine-rich splicing factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="20">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="77"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019439.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="164" mass="19121" checksum="ED27FD8B7C0A8FB0" modified="2022-01-19" version="1">THRDSCPLDCKVYVGNLGNNGNKTELERAFGYSGPLRSVWVARNPPGFAFAEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDGYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSPSRERNHKPSRSFSRSRSRSRSNERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHU5</accession>
    <name>A0A8C5XHU5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 23">Dihydropyrimidine dehydrogenase [NADP(+)]</fullName>
            <shortName evidence="23">DHPDHase</shortName>
            <shortName evidence="23">DPD</shortName>
            <ecNumber evidence="5 23">1.3.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19 23">Dihydrothymine dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 23">Dihydrouracil dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">DPYD</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>5,6-dihydrothymine + NADP(+) = thymine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:27468"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:58286"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18093"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.2"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:18095"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 23">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="23">Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 23">Amino-acid biosynthesis; beta-alanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the dihydropyrimidine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.2" evidence="5 23"/>
    <dbReference type="EMBL" id="ABDC03002797">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002799">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646466.1">
        <property type="nucleotide sequence ID" value="XM_012791012.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XHU5"/>
    <dbReference type="Ensembl" id="ENSMICT00000049866.2">
        <property type="protein sequence ID" value="ENSMICP00000024009.1"/>
        <property type="gene ID" value="ENSMICG00000003295.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885769"/>
    <dbReference type="KEGG" id="mmur:105885769"/>
    <dbReference type="CTD" id="1806"/>
    <dbReference type="GeneTree" id="ENSGT00500000044896"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00131"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017113">
        <property type="term" value="F:dihydropyrimidine dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002058">
        <property type="term" value="F:uracil binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019483">
        <property type="term" value="P:beta-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006248">
        <property type="term" value="P:CMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006249">
        <property type="term" value="P:dCMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046079">
        <property type="term" value="P:dUMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006214">
        <property type="term" value="P:thymidine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046050">
        <property type="term" value="P:UMP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02940">
        <property type="entry name" value="DHPD_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000007">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000027">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000023">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000056">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000061">
        <property type="entry name" value="Dihydropyrimidine dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43073:SF2">
        <property type="entry name" value="DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14697">
        <property type="entry name" value="Fer4_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 23" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 23" id="KW-0274">FAD</keyword>
    <keyword evidence="8 23" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 23" id="KW-0288">FMN</keyword>
    <keyword evidence="16 23" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 23" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="24">
        <location>
            <begin position="944"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="24">
        <location>
            <begin position="978"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00055719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU364041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111758" checksum="5001B9625773B354" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNK6</accession>
    <name>A0A8C5XNK6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inactive carboxypeptidase-like protein X2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CPXM2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell-cell interactions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019527">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNK6"/>
    <dbReference type="Ensembl" id="ENSMICT00000050128.2">
        <property type="protein sequence ID" value="ENSMICP00000038327.2"/>
        <property type="gene ID" value="ENSMICG00000008842.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156414"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00057">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03869">
        <property type="entry name" value="M14_CPX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11308">
        <property type="entry name" value="Peptidase_M14NE-CP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000007">
        <property type="entry name" value="Carboxypeptidase X (M14 family), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1120:FF:000007">
        <property type="entry name" value="Carboxypeptidase X, M14 family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000035">
        <property type="entry name" value="probable carboxypeptidase X1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF45">
        <property type="entry name" value="INACTIVE CARBOXYPEPTIDASE-LIKE PROTEIN X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13620">
        <property type="entry name" value="CarboxypepD_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00231">
        <property type="entry name" value="FA58C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="Carboxypeptidase regulatory domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01285">
        <property type="entry name" value="FA58C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01286">
        <property type="entry name" value="FA58C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034675555" description="Inactive carboxypeptidase-like protein X2" evidence="11">
        <location>
            <begin position="26"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="130"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="13">
        <location>
            <begin position="313"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038327.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="752" mass="84915" checksum="3DF872B090AB7A2D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNY2</accession>
    <name>A0A8C5XNY2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane p24 trafficking protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TMED9</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033454">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642824.1">
        <property type="nucleotide sequence ID" value="XM_012787370.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNY2"/>
    <dbReference type="Ensembl" id="ENSMICT00000047392.2">
        <property type="protein sequence ID" value="ENSMICP00000038557.1"/>
        <property type="gene ID" value="ENSMICG00000027542.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105883863"/>
    <dbReference type="KEGG" id="mmur:105883863"/>
    <dbReference type="CTD" id="54732"/>
    <dbReference type="GeneTree" id="ENSGT00940000159747"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 32"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150340" evidence="11">
        <location>
            <begin position="39"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="12">
        <location>
            <begin position="48"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="236" mass="27393" checksum="E48E0F7AABFF1F0A" modified="2022-01-19" version="1">MAAERGVRGVRPPPGPRLGGMMRTLLLLLLWFAARGTALYFHIGETEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIGVWQMRHLKSFFEAKKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XP46</accession>
    <name>A0A8C5XP46_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mothers against decapentaplegic homolog</fullName>
            <shortName evidence="12">MAD homolog</shortName>
            <shortName evidence="12">Mothers against DPP homolog</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">SMAD family member</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SMAD4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the dwarfin/SMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022215">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625279.2">
        <property type="nucleotide sequence ID" value="XM_012769825.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138034.1">
        <property type="nucleotide sequence ID" value="XM_020282445.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XP46"/>
    <dbReference type="Ensembl" id="ENSMICT00000029415.2">
        <property type="protein sequence ID" value="ENSMICP00000038516.2"/>
        <property type="gene ID" value="ENSMICG00000017525.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874233"/>
    <dbReference type="KEGG" id="mmur:105874233"/>
    <dbReference type="CTD" id="4089"/>
    <dbReference type="GeneTree" id="ENSGT00940000157435"/>
    <dbReference type="OrthoDB" id="5875866at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071144">
        <property type="term" value="C:heteromeric SMAD protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070411">
        <property type="term" value="F:I-SMAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060395">
        <property type="term" value="P:SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007179">
        <property type="term" value="P:transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10492">
        <property type="entry name" value="MH1_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10498">
        <property type="entry name" value="MH2_SMAD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.520.10:FF:000002">
        <property type="entry name" value="Mothers against decapentaplegic homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.520.10">
        <property type="entry name" value="SMAD MH1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013790">
        <property type="entry name" value="Dwarfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013019">
        <property type="entry name" value="MAD_homology_MH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017855">
        <property type="entry name" value="SMAD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001132">
        <property type="entry name" value="SMAD_dom_Dwarfin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036578">
        <property type="entry name" value="SMAD_MH1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703:SF63">
        <property type="entry name" value="MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13703">
        <property type="entry name" value="SMAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
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    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
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    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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            <begin position="18"/>
            <end position="142"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="552" mass="60485" checksum="DE83CAB239E2E653" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XRI8</accession>
    <name>A0A8C5XRI8_MICMU</name>
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        <submittedName>
            <fullName evidence="8">Erythrocyte membrane protein band 4.1 like 1</fullName>
        </submittedName>
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        <name evidence="8" type="primary">EPB41L1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
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        </subcellularLocation>
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        <property type="component" value="Chromosome 18"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0003779">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural molecule activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="4.1 G PROTEIN"/>
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            <dbReference type="PROSITE" id="PS50057"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XRK6</accession>
    <name>A0A8C5XRK6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Protocadherin 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">PCDH7</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XRK6"/>
    <dbReference type="Ensembl" id="ENSMICT00000027009.2">
        <property type="protein sequence ID" value="ENSMICP00000040086.1"/>
        <property type="gene ID" value="ENSMICG00000028654.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157221"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11304">
        <property type="entry name" value="Cadherin_repeat"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000028">
        <property type="entry name" value="Protocadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000034">
        <property type="entry name" value="Protocadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000043">
        <property type="entry name" value="Protocadherin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000005">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000016">
        <property type="entry name" value="Protocadherin 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000073">
        <property type="entry name" value="protocadherin-7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.60:FF:000270">
        <property type="entry name" value="protocadherin-7 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.60">
        <property type="entry name" value="Cadherins"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020894">
        <property type="entry name" value="Cadherin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013164">
        <property type="entry name" value="Cadherin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013585">
        <property type="entry name" value="Protocadherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050174">
        <property type="entry name" value="Protocadherin/Cadherin-CA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028">
        <property type="entry name" value="CADHERIN-87A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24028:SF253">
        <property type="entry name" value="PROTOCADHERIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00028">
        <property type="entry name" value="Cadherin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08266">
        <property type="entry name" value="Cadherin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08374">
        <property type="entry name" value="Protocadherin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00205">
        <property type="entry name" value="CADHERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00112">
        <property type="entry name" value="CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00232">
        <property type="entry name" value="CADHERIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034011114" evidence="15">
        <location>
            <begin position="31"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="52"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="144"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="303"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="426"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="530"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="634"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="16">
        <location>
            <begin position="739"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="904"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="924"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118088" checksum="7C8749C81FA187BB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XS44</accession>
    <name>A0A8C5XS44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galanin receptor type 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">GALR3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008875">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XS44"/>
    <dbReference type="Ensembl" id="ENSMICT00000050146.2">
        <property type="protein sequence ID" value="ENSMICP00000040221.2"/>
        <property type="gene ID" value="ENSMICG00000038753.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286969"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004966">
        <property type="term" value="F:galanin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007187">
        <property type="term" value="P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090663">
        <property type="term" value="P:galanin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000244">
        <property type="entry name" value="galanin receptor type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000405">
        <property type="entry name" value="Galanin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003908">
        <property type="entry name" value="Galnin_3_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695:SF33">
        <property type="entry name" value="GALANIN RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45695">
        <property type="entry name" value="LEUCOKININ RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01420">
        <property type="entry name" value="GALANIN3R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00663">
        <property type="entry name" value="GALANINR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="17">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040221.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="363" mass="39081" checksum="6AD6F87A1EA1CEB9" modified="2022-01-19" version="1">MADAQNISLDNPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRTRCPRVHPASSGPGGCTLGDARPRGRLPARGGWGGEPREGPAHSGEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYE1</accession>
    <name>A0A8C5XYE1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dual specificity protein phosphatase 19</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Protein phosphatase SKRP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Stress-activated protein kinase pathway-regulating phosphatase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">DUSP19</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Has a dual specificity toward Ser/Thr and Tyr-containing proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10685"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03011034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143894.1">
        <property type="nucleotide sequence ID" value="XM_020288305.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYE1"/>
    <dbReference type="Ensembl" id="ENSMICT00000059677.1">
        <property type="protein sequence ID" value="ENSMICP00000043366.1"/>
        <property type="gene ID" value="ENSMICG00000006787.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882994"/>
    <dbReference type="CTD" id="142679"/>
    <dbReference type="GeneTree" id="ENSGT00940000156472"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008579">
        <property type="term" value="F:JUN kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14523">
        <property type="entry name" value="DSP_DUSP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000071">
        <property type="entry name" value="Dual specificity protein phosphatase 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46377:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="14">
        <location>
            <begin position="65"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="15">
        <location>
            <begin position="133"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="210" mass="23360" checksum="D82BDC680F1FA08F" modified="2022-01-19" version="1">MHSLNQEIKAFSRNNLRKQCTRVTTLTGKKIIETWKDARIHVVEELEPSSGGGCGYVQDLSLDLQVGVIKPWLLLGSQDAAHDLDTLKKHKVTHILNVAYGVENAFLSDFTYKSISILDLPETNILSYFPECFEFIEQAKMKDGVVLVHCNAGVSRAAAIVIGFLMNSEETSFTSAFSLVKNARPSICPNSGFVEQLRTYQEGKESNKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZ26</accession>
    <name>A0A8C5XZ26_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KiSS-1 metastasis suppressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">KISS1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03029876">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZ26"/>
    <dbReference type="Ensembl" id="ENSMICT00000062244.1">
        <property type="protein sequence ID" value="ENSMICP00000043719.1"/>
        <property type="gene ID" value="ENSMICG00000046282.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008827"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031773">
        <property type="term" value="F:kisspeptin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020207">
        <property type="entry name" value="Metastasis-suppressor_KiSS-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16955">
        <property type="entry name" value="METASTASIS-SUPPRESSOR KISS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16955:SF6">
        <property type="entry name" value="METASTASIS-SUPPRESSOR KISS-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15152">
        <property type="entry name" value="Kisspeptin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034236449" evidence="2">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="138" mass="14518" checksum="F49D46C0C2A120A8" modified="2022-01-19" version="1">MNCLVSWQLLLFLCATSLGDPLEKGAPVENPRATGQQLRPQDLLAAWAQSPRCAETRPAAAALSPRGAPLCAPPDGAAGPQRPGPCAPRSRLIPAPRGAVLVQREKDLSAYNWNSFGLRYGKRQAAPGSRRGPGAGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZY0</accession>
    <name>A0A8C5XZY0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Testis expressed 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TEX54</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005845">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZY0"/>
    <dbReference type="Ensembl" id="ENSMICT00000060564.1">
        <property type="protein sequence ID" value="ENSMICP00000043521.1"/>
        <property type="gene ID" value="ENSMICG00000046387.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00700000106100"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="117" mass="13362" checksum="F8219793BABA1D4D" modified="2022-01-19" version="1">MGCCQDKDFATSDEQGKDSDSEDDRGPREREIGWEWVGRESAGDTELDSPGNRNRRSKSNESLLITVLWRRLSMFSRRGSARSSGKRQSEGVHRDSPIQENNEEETQEETQEEPEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y0H1</accession>
    <name>A0A8C5Y0H1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome b-c1 complex subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Complex III subunit XI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquinol-cytochrome c reductase complex 6.4 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">UQCR11</name>
        <name evidence="17" type="synonym">LOC105860777</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the UQCR11/QCR10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601217.1">
        <property type="nucleotide sequence ID" value="XM_012745763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y0H1"/>
    <dbReference type="Ensembl" id="ENSMICT00000063071.1">
        <property type="protein sequence ID" value="ENSMICP00000043867.1"/>
        <property type="gene ID" value="ENSMICG00000047280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105860777"/>
    <dbReference type="KEGG" id="mmur:105860777"/>
    <dbReference type="GeneTree" id="ENSGT00390000018299"/>
    <dbReference type="OMA" id="LAKNWMP"/>
    <dbReference type="OrthoDB" id="15743at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.220:FF:000004">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029027">
        <property type="entry name" value="Single_a-helix_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015089">
        <property type="entry name" value="UQCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15420:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15420">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 6.4 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08997">
        <property type="entry name" value="UCR_6-4kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81518">
        <property type="entry name" value="Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="56" mass="6603" checksum="B9BA92453917B7FF" modified="2022-01-19" version="1">MLTRFLGPRYRELAKNWMPTAGMWGTVGAVGLVWMTDWRLILDWVPYINGKFKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3Y0</accession>
    <name>A0A8C5Y3Y0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sprouty RTK signaling antagonist 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPRY4</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sprouty family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022508">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3Y0"/>
    <dbReference type="Ensembl" id="ENSMICT00000064550.1">
        <property type="protein sequence ID" value="ENSMICP00000045143.1"/>
        <property type="gene ID" value="ENSMICG00000047702.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183055"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900025">
        <property type="term" value="P:negative regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007875">
        <property type="entry name" value="Sprouty"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051192">
        <property type="entry name" value="Sprouty_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365:SF6">
        <property type="entry name" value="PROTEIN SPROUTY HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12365">
        <property type="entry name" value="SPROUTY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05210">
        <property type="entry name" value="Sprouty"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51227">
        <property type="entry name" value="SPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="322" mass="34831" checksum="7670D89F84703C44" modified="2022-01-19" version="1">VLSPLPTGPLEACFSVQPRTSSSMEPPIPQSTPLTPSSVMVQPILDSRMPHSRLQHPLTILPIDQMKTSHVENDYIDNPSLAPTAGPKRTRAGAPELAPTPARCDQDVTHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPVADQASPRAVRIQPKVVHCKPLDLKGPAVPPELDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGVFYHCTNEDDEGSCADHPCSCSHSNCCARWSFMGALSLVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAAGGDAKASRPDKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAP4</accession>
    <name>A0A8C5YAP4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ankyrin repeat and SOCS box containing 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ASB9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ankyrin SOCS box (ASB) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035917">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640233.1">
        <property type="nucleotide sequence ID" value="XM_012784779.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640234.1">
        <property type="nucleotide sequence ID" value="XM_012784780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAP4"/>
    <dbReference type="Ensembl" id="ENSMICT00000003163.3">
        <property type="protein sequence ID" value="ENSMICP00000002870.2"/>
        <property type="gene ID" value="ENSMICG00000003161.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065208.1">
        <property type="protein sequence ID" value="ENSMICP00000048236.1"/>
        <property type="gene ID" value="ENSMICG00000003161.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882418"/>
    <dbReference type="KEGG" id="mmur:105882418"/>
    <dbReference type="CTD" id="140462"/>
    <dbReference type="GeneTree" id="ENSGT00940000157160"/>
    <dbReference type="OrthoDB" id="3246549at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031466">
        <property type="term" value="C:Cul5-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.750.20:FF:000001">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000016">
        <property type="entry name" value="Ankyrin repeat and SOCS box containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.750.20">
        <property type="entry name" value="SOCS box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051573">
        <property type="entry name" value="Ankyrin-SOCS_box_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001496">
        <property type="entry name" value="SOCS_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036036">
        <property type="entry name" value="SOCS_box-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136:SF17">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24136">
        <property type="entry name" value="SOWAH (DROSOPHILA) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07525">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00969">
        <property type="entry name" value="SOCS_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158235">
        <property type="entry name" value="SOCS box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50225">
        <property type="entry name" value="SOCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="68"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="101"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="SOCS box" evidence="8">
        <location>
            <begin position="244"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="294" mass="31831" checksum="643F9CD4D47B0E47" modified="2022-01-19" version="1">MDGKRGRRMGSKPPGSGGSPDTRLVTNPMMGDVVSDWSPMHEAALHGRLLSLRNLISQGWPVNLVTADGVSPLHEACLRGHLSCANVLLSHGAKVNGVTAYWHTPLFNACVSGNRDCVNVLLQHGASPHPVTNLASPIHEAAKRGHVECVEALMVHGSNIDHNISHLGTPLYVACENQQIACARKLLESGASVNQGRGLDSPLHVVARTCSEELASLLMDFGADTQAKNGEGKCPMDLVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGTRQHHKITGLILPEELKRFLLHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YBQ2</accession>
    <name>A0A8C5YBQ2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM26</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019244">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618208.1">
        <property type="nucleotide sequence ID" value="XM_012762754.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YBQ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000060341.1">
        <property type="protein sequence ID" value="ENSMICP00000048715.1"/>
        <property type="gene ID" value="ENSMICG00000047022.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870261"/>
    <dbReference type="KEGG" id="mmur:105870261"/>
    <dbReference type="CTD" id="219623"/>
    <dbReference type="GeneTree" id="ENSGT00390000014794"/>
    <dbReference type="OrthoDB" id="10042902at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019169">
        <property type="entry name" value="Transmembrane_26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168">
        <property type="entry name" value="TMEM26 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22168:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09772">
        <property type="entry name" value="Tmem26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="372" mass="41357" checksum="BC44F0C8B02E62BD" modified="2022-01-19" version="1">MEGLVLLNALATRLLFVLHSLVGVWRVTEVKKEPWYWLLALLNLLLFLETVLTLKFKSGRGYKWFSPAIFLYLISIVPSLWLLEMHHETQYCSIQSEENSQNASRKEDFNPTLMSSEQTNGTDDLIKTAKVFVSNLSTVCEKVWTLGLHQTFLLMLIIGRWLLPIGGGITRDQLSQLLLIFVGTAADILEFTSETLEEQNVRNSPALVYAILIIWTWSMLQFPLDLAVQSVACPVSVTARGFLGLFFCRYSADLWNIGISVFIQDGPFLVVRLILMAHFKVINQMLVFFAAKNFLVVVLQLYRLAVLALGARASSQPPAGGPRGQHGCGGQPCERGLSPQDWGSEPQEGLALPLRATPVASDDTSGDPHPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YDY9</accession>
    <name>A0A8C5YDY9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc finger HIT domain-containing protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Thyroid hormone receptor interactor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Thyroid receptor-interacting protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNHIT3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Thyroid receptor interacting proteins (TRIPs) specifically interact with the ligand binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with NUFIP1. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03019989">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634495.1">
        <property type="nucleotide sequence ID" value="XM_012779041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YDY9"/>
    <dbReference type="Ensembl" id="ENSMICT00000063898.1">
        <property type="protein sequence ID" value="ENSMICP00000050257.1"/>
        <property type="gene ID" value="ENSMICG00000041948.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879052"/>
    <dbReference type="KEGG" id="mmur:105879052"/>
    <dbReference type="CTD" id="9326"/>
    <dbReference type="GeneTree" id="ENSGT00390000010822"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000002">
        <property type="entry name" value="Zinc finger HIT domain-containing protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048371">
        <property type="entry name" value="ZNHIT3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF11">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21373">
        <property type="entry name" value="ZNHIT3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="14">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="155" mass="17596" checksum="BF8B291A2ABF7DFF" modified="2022-01-19" version="1">MASLNCSTVVCVICLEKPKYRCPACRVPYCSVTCFRKHKEQCNPETRPVERRIRSAVPAKTVKPVENKDDDSSVADFLNSDEEEDRVSLQNLKNLEESTALRSLLLNPHLRQLMISLDQGDDKAQLMRAYMQEPLFVEFADCCLGIVEPSQNEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEZ5</accession>
    <name>A0A8C5YEZ5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Retinoic acid receptor responder 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RARRES1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the protease inhibitor I47 (latexin) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000729">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEZ5"/>
    <dbReference type="Ensembl" id="ENSMICT00000073228.1">
        <property type="protein sequence ID" value="ENSMICP00000050802.1"/>
        <property type="gene ID" value="ENSMICG00000049120.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063813"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008191">
        <property type="term" value="F:metalloendopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.10:FF:000021">
        <property type="entry name" value="Retinoic acid receptor responder (tazarotene-induced) 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049897">
        <property type="entry name" value="CYSTATIN_LXN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009684">
        <property type="entry name" value="Latexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28591">
        <property type="entry name" value="LATEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28591:SF2">
        <property type="entry name" value="RETINOIC ACID RECEPTOR RESPONDER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06907">
        <property type="entry name" value="LXN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52033">
        <property type="entry name" value="CYSTATIN_LXN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034951284" evidence="5">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin LXN-type" evidence="6">
        <location>
            <begin position="41"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin LXN-type" evidence="6">
        <location>
            <begin position="167"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="221" mass="24819" checksum="BE7B1E34EFEED104" modified="2022-01-19" version="1">MQPHRQPPPAPQPGARLLALLLLLVLQAAAAPAASGGPEDPRQPLDAGPSRGLLQRAARAALHFLNFRSGSPSALRVLAAVQEGRARINPKEGCKVDLVFSTERYNSESLFEGEERLGKCSARVFFKNQKPRPAINVTCTRLLEKQKRQQEDYLLYKQMKQLKTPLDVVSIPDSHGHIDPSLRPIWDLAFLGSSYVMWEKTTQFLHYYLAQLTSVKQWVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGE7</accession>
    <name>A0A8C5YGE7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mucin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC105883045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03029040">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641359.1">
        <property type="nucleotide sequence ID" value="XM_012785905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGE7"/>
    <dbReference type="Ensembl" id="ENSMICT00000060148.1">
        <property type="protein sequence ID" value="ENSMICP00000050553.1"/>
        <property type="gene ID" value="ENSMICG00000043840.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105883045"/>
    <dbReference type="CTD" id="4589"/>
    <dbReference type="GeneTree" id="ENSGT00730000111663"/>
    <dbReference type="OrthoDB" id="9751660at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070062">
        <property type="term" value="C:extracellular exosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033529">
        <property type="entry name" value="MUC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41683">
        <property type="entry name" value="MUCIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41683:SF1">
        <property type="entry name" value="MUCIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150590" description="Mucin-7" evidence="2">
        <location>
            <begin position="23"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="32720" checksum="43713D832889A084" modified="2022-01-19" version="1">MKTLPLLVCICALSACFSLSEGRKKHRELFHQRHHPHRPRPAYQFPPPSRPLYHQNPFIRKPPHVGPHKPHKRPPHSANKPPKFPNNQLPPKCPIKNDIINKNTTTQIPPLNSPSASTKIPTSPGLNPLAQNTTAIPSGENNANTGSSVAGSIPPRVPDTTAAPPVETTAAPPVTTAAPPLETTAAPPETTAAPPVTTAAPPLETTAAPPVTTAVPPLETTAAPPETTAAPPVTTAAPPVTTAAPPNTTVPETTAAPSNAAPEPSKTTAAPTNQTTTVKQPTSSPTQNKISQFLTAFENKLKRIFEYLLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YHS0</accession>
    <name>A0A8C5YHS0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Forkhead box protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">FOXL2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03000015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604566.1">
        <property type="nucleotide sequence ID" value="XM_012749112.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YHS0"/>
    <dbReference type="Ensembl" id="ENSMICT00000073280.1">
        <property type="protein sequence ID" value="ENSMICP00000051644.1"/>
        <property type="gene ID" value="ENSMICG00000049490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105862659"/>
    <dbReference type="KEGG" id="mmur:105862659"/>
    <dbReference type="CTD" id="668"/>
    <dbReference type="GeneTree" id="ENSGT00940000162075"/>
    <dbReference type="OrthoDB" id="6230630at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090543">
        <property type="term" value="C:Flemming body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043028">
        <property type="term" value="F:cysteine-type endopeptidase regulator activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002074">
        <property type="term" value="P:extraocular skeletal muscle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001541">
        <property type="term" value="P:ovarian follicle development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20028">
        <property type="entry name" value="FH_FOXL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000016">
        <property type="entry name" value="Forkhead box protein I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047515">
        <property type="entry name" value="FH_FOXL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF411">
        <property type="entry name" value="FORKHEAD BOX PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Fork-head" evidence="13">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="11">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="276"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="376" mass="38890" checksum="1C7B1106580F5137" modified="2022-01-19" version="1">MMASYPEPEDAAGALLAPETGRTVKEPEAPPPSPGKGGGSGGGTVPEKPDPAQKPPYSYVALIAMAIRESAEKRLTLSGIYQYIIAKFPFYEKNKKGWQNSIRHNLSLNECFIKVPREGGGERKGNYWTLDPACEDMFEKGNYRRRRRMKRPFRPPPAHFQPGKGLFGAGGAAGGCGVAGAGADGYGYLAPPKYLQSGFLNNSWPLPQPPSPMPYASCQMAAAAAAAAAAAAAAGPGSPGAAAVVKGLAGPAASYGPYSRVQSMALPPGVVNSYNGLGGPPAAPPPPPHPHPHPHAHHLHAAAAPPPAPPHHGATAPPPGQLSPASPATAAPPAPAPTSAPGLQFACARQPELAMMHCSYWDHDSKTSALHSRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EH00</accession>
    <name>A0A8C6EH00_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-dependent metalloprotease SPRTN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Protein with SprT-like domain at the N terminus</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SPRTN</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Spartan family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021241">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EH00"/>
    <dbReference type="Ensembl" id="ENSMICT00000064438.1">
        <property type="protein sequence ID" value="ENSMICP00000041868.1"/>
        <property type="gene ID" value="ENSMICG00000029926.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003585"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106300">
        <property type="term" value="P:protein-DNA covalent cross-linking repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000331">
        <property type="entry name" value="E3 ubiquitin-protein ligase RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51908">
        <property type="entry name" value="ZF_UBZ4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="18">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="344"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023885"/>
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    </evidence>
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        </source>
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    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="493" mass="55628" checksum="A8181C4F0EAA5441" modified="2022-01-19" version="1">MDEDLVLALRLQEEWDLQVAERDRAQEPLSLVDASWELVDPTPDLQALFVQFNDRFFWGQLEAVEVKWSMRMTLCAGICSYEGKGGMCSIRLSEPLLKLRPRKDLVETLLHEMIHAYLFVTNNDKDREGHGPEFCKHMHRINRLTGANITIYHTFHDEVDEYRRHWWRCDGPCQHKQPYYGYVKRATNRAPSANDYWWAEHQKTCGGTYIKIKEPENYSKKGKGKTKPGKHPASAIENKDKPNRGQAQLLIPFSGKGYVLGETSNLPSSGKSISSQAINKTQDLLSQDHSANTLRPNSKTQVKFEQNGSSKKTSHLISPVLNTSHQNVLSNYFPRVSAANQKAFRSVNGSSPTKSLTVGDITKNSVSSSSQRRVTSSKKSLRNSLKAVESTSVTASQEVSGSEDKFPNKRPRLEDKTVFDNFFIKKEQMQSDGNDPKCSSRPITTTQNSNSSCSQSKMVNCPVCQNKVLESQINEHLDLCLASDSIEVKSKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EIK4</accession>
    <name>A0A8C6EIK4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma</fullName>
            <ecNumber evidence="9">3.1.4.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PDE6H</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7 9">Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.1.4.35"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the rod/cone cGMP-PDE gamma subunit family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.35" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03010214">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609203.1">
        <property type="nucleotide sequence ID" value="XM_012753749.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609204.1">
        <property type="nucleotide sequence ID" value="XM_012753750.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609205.1">
        <property type="nucleotide sequence ID" value="XM_012753751.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609206.1">
        <property type="nucleotide sequence ID" value="XM_012753752.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609207.1">
        <property type="nucleotide sequence ID" value="XM_012753753.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609208.1">
        <property type="nucleotide sequence ID" value="XM_012753754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EIK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000064060.1">
        <property type="protein sequence ID" value="ENSMICP00000045097.1"/>
        <property type="gene ID" value="ENSMICG00000044536.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105865294"/>
    <dbReference type="KEGG" id="mmur:105865294"/>
    <dbReference type="CTD" id="5149"/>
    <dbReference type="GeneTree" id="ENSGT00390000013260"/>
    <dbReference type="OrthoDB" id="8525078at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042622">
        <property type="term" value="C:photoreceptor outer segment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045745">
        <property type="term" value="P:positive regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1120.10:FF:000001">
        <property type="entry name" value="retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1120.10">
        <property type="entry name" value="Retinal cGMP phosphodiesterase, gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006952">
        <property type="entry name" value="PDE6_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037030">
        <property type="entry name" value="PDE6_gamma_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12122">
        <property type="entry name" value="RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE GAMMA-SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12122:SF5">
        <property type="entry name" value="RETINAL CONE RHODOPSIN-SENSITIVE CGMP 3',5'-CYCLIC PHOSPHODIESTERASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04868">
        <property type="entry name" value="PDE6_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000969">
        <property type="entry name" value="35-cGMP_Pdiase_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0140">cGMP</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="6" id="KW-0844">Vision</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="83" mass="9075" checksum="9E43741463EBBDD3" modified="2022-01-19" version="1">MSDSTTLVPPASNQGPTTPRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELAQFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJ23</accession>
    <name>A0A8C6EJ23_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03036436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJ23"/>
    <dbReference type="Ensembl" id="ENSMICT00000062736.1">
        <property type="protein sequence ID" value="ENSMICP00000046130.1"/>
        <property type="gene ID" value="ENSMICG00000038133.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153341"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="59"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="316" mass="34560" checksum="5C35A9779FDAC4EE" modified="2025-10-08" version="2">MSSEKPATPTPSSRPPGAPALSAAHTKPGTTGSGAGSGGPGGLTSVAPAAGDKKIIARKVLGTVKWFNVRNGYGFINRNDTKEDVFVHQTAIKKNNPRKDLRSAGDGETVGFDVVKGEKDTEAANVAGPGGIPVQGSKYAADRNHYRRYPRRRVPLRNYQQNYQNSDSGEKNEGPEGAPEGQAQQHRPYRRRRSPPYYTRRPHGRRPQDSNPPVQGAVMEGAENQGAGEPGRPPVRQNMGPPRQRQPREDGNEEDKENQGDETQGQQPPQRRYRRNFNYRRRRPENPKPQDGKETKAADPPAENPSAPEAEQGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJB4</accession>
    <name>A0A8C6EJB4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NANOG neighbor homeobox</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NANOGNB</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010425">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJB4"/>
    <dbReference type="Ensembl" id="ENSMICT00000060321.1">
        <property type="protein sequence ID" value="ENSMICP00000046694.1"/>
        <property type="gene ID" value="ENSMICG00000041549.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00400000025247"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034019578" evidence="4">
        <location>
            <begin position="20"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="87"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="89"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="35"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="156" mass="18404" checksum="77007B675450C716" modified="2022-01-19" version="1">VGRARWLTPVILALWEAEAGRLLELIIQKQPAMLWDPSPEQSSKNCKEEEGTKKQKCREEETAGGGDKEEEVEKELEEEQKKEKENGEGCPRKRLVGKSLMDTLWGKFKLNKYLTIQDTLSLSFEFSMTNRQINQWFCRKRKTYNKEMSKRKYNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJN6</accession>
    <name>A0A8C6EJN6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJN6"/>
    <dbReference type="Ensembl" id="ENSMICT00000058398.1">
        <property type="protein sequence ID" value="ENSMICP00000047414.1"/>
        <property type="gene ID" value="ENSMICG00000047520.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065900.1">
        <property type="protein sequence ID" value="ENSMICP00000049891.1"/>
        <property type="gene ID" value="ENSMICG00000047520.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000143202"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="72" mass="8649" checksum="80F7AFEAC42C2831" modified="2022-01-19" version="1">MGQGQQAMCPEALFDLKRWLLYTFCNWFDITFQLQLFILRTLNCFCRSISYNLKDLKTFWLPQAYLSSLLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6ELL2</accession>
    <name>A0A8C6ELL2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-phosphoxylose phosphatase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Acid phosphatase-like protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PXYLP1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>3-O-[beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1-&gt;3)-beta-D-Gal-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Xyl)-L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:56512"/>
            <dbReference type="Rhea" id="RHEA-COMP:12573"/>
            <dbReference type="Rhea" id="RHEA-COMP:14559"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:132093"/>
            <dbReference type="ChEBI" id="CHEBI:140495"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with B3GAT3; the interaction increases the 2-phosphoxylose phosphatase activity of PXYLP1 during completion of linkage region formation in a B3GAT3-mediated manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000672">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617757.1">
        <property type="nucleotide sequence ID" value="XM_012762303.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617758.1">
        <property type="nucleotide sequence ID" value="XM_012762304.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617759.1">
        <property type="nucleotide sequence ID" value="XM_012762305.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617760.1">
        <property type="nucleotide sequence ID" value="XM_012762306.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617761.1">
        <property type="nucleotide sequence ID" value="XM_012762307.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617762.1">
        <property type="nucleotide sequence ID" value="XM_012762308.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617763.1">
        <property type="nucleotide sequence ID" value="XM_012762309.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617764.1">
        <property type="nucleotide sequence ID" value="XM_012762310.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617765.1">
        <property type="nucleotide sequence ID" value="XM_012762311.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617766.1">
        <property type="nucleotide sequence ID" value="XM_012762312.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617767.1">
        <property type="nucleotide sequence ID" value="XM_012762313.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617768.1">
        <property type="nucleotide sequence ID" value="XM_012762314.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020141653.1">
        <property type="nucleotide sequence ID" value="XM_020286064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6ELL2"/>
    <dbReference type="Ensembl" id="ENSMICT00000072663.1">
        <property type="protein sequence ID" value="ENSMICP00000051024.1"/>
        <property type="gene ID" value="ENSMICG00000048945.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000072899.1">
        <property type="protein sequence ID" value="ENSMICP00000051519.1"/>
        <property type="gene ID" value="ENSMICG00000048945.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105870040"/>
    <dbReference type="KEGG" id="mmur:105870040"/>
    <dbReference type="CTD" id="92370"/>
    <dbReference type="GeneTree" id="ENSGT00390000016324"/>
    <dbReference type="OMA" id="DWEWNYY"/>
    <dbReference type="OrthoDB" id="10262962at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010909">
        <property type="term" value="P:positive regulation of heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000011">
        <property type="entry name" value="2-phosphoxylose phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00064343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="480" mass="55190" checksum="3E7346B5D3CCAB5F" modified="2022-01-19" version="1">MLFRNRFLLLLALAALLAFLSLSLQFFHLIPVSTAKDGVSSKSRKRIMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEGHAPHHFKLVSVNVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFVSHMSKGSGASFESPLNSLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLKKHKLLPSDWSTDQLYLETTGKSRTLQSGLALLYGFLPEFDWKKIYFRHQPSALFCSGNCYCPVRNQYLEKEQRRQYLLRLKNSQLERTYGEMAKIVDVPTKQLRAANPVDSMLCHFCHNVSFPCTRNGCIGMEHFKVIKTHQIEDERERREKKLYLGYSLLGAHPILNQTVNRLQRAAEGRKEEIFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDREKPSEHSVRILYNGVDVTFHTSFCQDHHKHSPKPMCPLENLVRFVKRDMFLALGSSSTNYYDACHREGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U2RWF4</accession>
    <name>A0A0U2RWF4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP synthase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ATP6</name>
        <name evidence="21" type="synonym">MT-ATP6</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="20 21"/>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Mitochondrial DNA A DNA Mapp Seq Anal" volume="27" first="3514" last="3516">
            <title>Complete mitochondrial genome of the gray mouse lemur, Microcebus murinus (Primates, Cheirogaleidae).</title>
            <authorList>
                <person name="Lecompte E."/>
                <person name="Crouau-Roy B."/>
                <person name="Aujard F."/>
                <person name="Holota H."/>
                <person name="Murienne J."/>
            </authorList>
            <dbReference type="PubMed" id="27158869"/>
            <dbReference type="DOI" id="10.3109/19401736.2015.1074196"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">920FAG</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="book" date="2016" name="THE DWARF AND MOUSE LEMURS OF MADAGASCAR" first="0" last="0" publisher="Cambridge University Press">
            <title>Mitogenomics of the family Cheirogaleidae and relationships to taxonomy and biogeography in Madagascar.</title>
            <editorList>
                <person name="Lehman"/>
                <person name="S.M. and Radespiel"/>
                <person name="U. and Zimmermann"/>
                <person name="E."/>
            </editorList>
            <authorList>
                <person name="Louis E.E. Jr."/>
                <person name="Lei R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">KIBO26</strain>
            <strain evidence="18">KIR6.32</strain>
            <strain evidence="19">LAVA7</strain>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>H(+)(in) = H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34979"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the ATP synthase complex composed at least of ATP5F1A/subunit alpha, ATP5F1B/subunit beta, ATP5MC1/subunit c (homooctomer), MT-ATP6/subunit a, MT-ATP8/subunit 8, ATP5ME/subunit e, ATP5MF/subunit f, ATP5MG/subunit g, ATP5MK/subunit k, ATP5MJ/subunit j, ATP5F1C/subunit gamma, ATP5F1D/subunit delta, ATP5F1E/subunit epsilon, ATP5PF/subunit F6, ATP5PB/subunit b, ATP5PD/subunit d, ATP5PO/subunit OSCP. ATP synthase complex consists of a soluble F(1) head domain (subunits alpha(3) and beta(3)) - the catalytic core - and a membrane F(0) domain - the membrane proton channel (subunits c, a, 8, e, f, g, k and j). These two domains are linked by a central stalk (subunits gamma, delta, and epsilon) rotating inside the F1 region and a stationary peripheral stalk (subunits F6, b, d, and OSCP). Interacts with DNAJC30; interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="KM112302">
        <property type="protein sequence ID" value="AIW63939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM112304">
        <property type="protein sequence ID" value="AIW63965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KM112306">
        <property type="protein sequence ID" value="AIW63991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KR911908">
        <property type="protein sequence ID" value="ALP29121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009192254.1">
        <property type="nucleotide sequence ID" value="NC_028718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U2RWF4"/>
    <dbReference type="Ensembl" id="ENSMICT00000049950.1">
        <property type="protein sequence ID" value="ENSMICP00000038722.1"/>
        <property type="gene ID" value="ENSMICG00000036548.1"/>
    </dbReference>
    <dbReference type="GeneID" id="26823979"/>
    <dbReference type="KEGG" id="mmur:26823979"/>
    <dbReference type="CTD" id="4508"/>
    <dbReference type="GeneTree" id="ENSGT00390000005568"/>
    <dbReference type="OrthoDB" id="5976622at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Bgee" id="ENSMICG00000036548">
        <property type="expression patterns" value="Expressed in colon and 8 other cell types or tissues"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000004">
        <property type="entry name" value="ATP synthase subunit a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045083">
        <property type="entry name" value="ATP_synth_F0_asu_bact/mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11410:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AIW63939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AIW63965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AIW63991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ALP29121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="226" mass="25058" checksum="882827F0AAE5959B" modified="2016-03-16" version="1">MNENLFASFIIPTIVGIPIVIFIIMFPSIFLHNPYRLIGNRLMSLQQWFIKLVLKQMMAIHNIKGRTWSLMLMSLILFIGSTNLLGLLPHSFTPTTQLSMNLGMAIPLWAAAVITGFRHKMKASLAHFLPQGTPIPLIPMLIIIETISLFIQPMALAVRLTANITAGHLLIHLIGGATMVLTSISPTVSSITFTILILLTILEFAVALIQAYVFTLLVSLYLHDNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ECR5</accession>
    <name>A0A8B7ECR5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DnaJ homolog subfamily C member 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DNAJC25</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DNAJC25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014818">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592162.1">
        <property type="nucleotide sequence ID" value="XM_012736708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ECR5"/>
    <dbReference type="Ensembl" id="ENSMICT00000006902.3">
        <property type="protein sequence ID" value="ENSMICP00000006288.2"/>
        <property type="gene ID" value="ENSMICG00000006903.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855655"/>
    <dbReference type="KEGG" id="mmur:105855655"/>
    <dbReference type="GeneTree" id="ENSGT00390000013355"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000036">
        <property type="entry name" value="dnaJ homolog subfamily C member 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044632">
        <property type="entry name" value="DNAJC25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44176:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133321" description="DnaJ homolog subfamily C member 25" evidence="9">
        <location>
            <begin position="39"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="49"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006288.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="360" mass="42472" checksum="53EDD83CC83A51CF" modified="2022-01-19" version="1">MAAPLAPRRGAGAAGRRWSVLLSPLLLLVLLRARPAGALVEGLYCGTRDCYEVLGVSRSAGKAEIARAYRQLARRYHPDRYRPEPGDEGPGRTPQSAEEAFLLVATAYETLKDEETRKDYDYMLDHPEEYYSHYYHYYSRRLAPKVDVRVVILVSVCAISVFQFFSWWNSYNKAISYLATVPKYRIQATEIARQQGLLKKAKEKGRNKKSKEEIRDEEENIIKNIIKSKIDIKGGYQKPQICDLLLFQIILAPFHLCSYIVWYCRWIYNFNIKGKEYGEEERLYIIRKSMKMSKSQFDSLEDHQKETFLKRELWIKENYEVYKQEQEEELKKKLANDPRWKRYRRWMKNEGPGRLTFVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQ89</accession>
    <name>A0A8B7EQ89_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ALX homeobox protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cartilage homeoprotein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ALX1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paired homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009348">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596276.1">
        <property type="nucleotide sequence ID" value="XM_012740822.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQ89"/>
    <dbReference type="Ensembl" id="ENSMICT00000039760.2">
        <property type="protein sequence ID" value="ENSMICP00000022762.1"/>
        <property type="gene ID" value="ENSMICG00000032710.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858005"/>
    <dbReference type="KEGG" id="mmur:105858005"/>
    <dbReference type="CTD" id="8092"/>
    <dbReference type="GeneTree" id="ENSGT00940000158251"/>
    <dbReference type="OMA" id="SSPCGDQ"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014031">
        <property type="term" value="P:mesenchymal cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010718">
        <property type="term" value="P:positive regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060021">
        <property type="term" value="P:roof of mouth development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048864">
        <property type="term" value="P:stem cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000093">
        <property type="entry name" value="ALX homeobox protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003654">
        <property type="entry name" value="OAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050649">
        <property type="entry name" value="Paired_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329:SF359">
        <property type="entry name" value="ALX HOMEOBOX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24329">
        <property type="entry name" value="HOMEOBOX PROTEIN ARISTALESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03826">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50803">
        <property type="entry name" value="OAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 13 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0371">Homeobox</keyword>
    <keyword evidence="11 13 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="OAR" evidence="16">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="13">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="36817" checksum="1C99E0FB5DBF500B" modified="2022-01-19" version="1">MEFLSEKFALKSPPSKNSDFYLGAGGALEHVMETLDNESFYSKASAGKCVQAFGPLPRAEHHVRLERTSPCQDGGVNYGITKVEGQALHTELNRAMDNCNSLRMSPVKGMQEKGELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDTSSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLSGATNGHAFETKPEFERRSSSIAVLRMKAKEHTANISWAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQU2</accession>
    <name>A0A8B7EQU2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synapse differentiation inducing 1 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SYNDIG1L</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003885">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597432.1">
        <property type="nucleotide sequence ID" value="XM_012741978.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597439.1">
        <property type="nucleotide sequence ID" value="XM_012741985.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQU2"/>
    <dbReference type="Ensembl" id="ENSMICT00000038291.2">
        <property type="protein sequence ID" value="ENSMICP00000022074.1"/>
        <property type="gene ID" value="ENSMICG00000027038.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858675"/>
    <dbReference type="KEGG" id="mmur:105858675"/>
    <dbReference type="CTD" id="646658"/>
    <dbReference type="GeneTree" id="ENSGT00950000183147"/>
    <dbReference type="OrthoDB" id="10018862at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14768:SF4">
        <property type="entry name" value="SYNAPSE DIFFERENTIATION-INDUCING GENE PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14768">
        <property type="entry name" value="UPF0338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="238" mass="25800" checksum="8D405C42FD38E4CE" modified="2022-01-19" version="1">MESLSELQNPLLPRSPAHLHGPCPYPEAPPSWSCQEKLYSYLLGGAGPTRAHQLLDPGSLQLAVEAWYRPSCLLGRDKVKEPKAGSCETSFTEGREPQAGPTERPTEPSQAEEDVTIQTVSYGVQEELQGQEDDQEEDESDATSTESESEDNFLTLPPRDHLGLTLFSMLCCFWPLGIAAFYFSQGTSKAISKGDFRLASTTSRRALFLATLSIAVGAGLYVAVVVALAAYMSQNGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ESL6</accession>
    <name>A0A8B7ESL6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">UFM1</name>
        <name evidence="13" type="synonym">LOC105870798</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. Ufmylation is involved in various processes, such as ribosome recycling, response to DNA damage, transcription or reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with UBA5. Interacts with UFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the UFM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017764">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017765">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598140.1">
        <property type="nucleotide sequence ID" value="XM_012742686.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ESL6"/>
    <dbReference type="SMR" id="A0A8B7ESL6"/>
    <dbReference type="Ensembl" id="ENSMICT00000060949.1">
        <property type="protein sequence ID" value="ENSMICP00000040978.1"/>
        <property type="gene ID" value="ENSMICG00000042483.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105859093"/>
    <dbReference type="KEGG" id="mmur:105859093"/>
    <dbReference type="CTD" id="51569"/>
    <dbReference type="GeneTree" id="ENSGT00390000010391"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042308">
        <property type="term" value="P:negative regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033146">
        <property type="term" value="P:regulation of intracellular estrogen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01766">
        <property type="entry name" value="Ubl_UFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000044">
        <property type="entry name" value="Ubiquitin-fold modifier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF5">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038027">
        <property type="entry name" value="Ubiquitin-like_Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="85" mass="9118" checksum="EDB2412E5E5836D8" modified="2022-01-19" version="1">MSKVSFKITLTSDPRLPYKVLSVPESTPFTAVLKFAAEEFKVPAATSAIITNDGIGINPAQTAGNVFLKHGSELRIIPRDRVGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F3I2</accession>
    <name>A0A8B7F3I2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase Hakai</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Casitas B-lineage lymphoma-transforming sequence-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase Hakai</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CBLL1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homodimer. Interacts with tyrosine-phosphorylated SRC substrates. Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM. The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B). Also a component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1, VIRMA, RBM15, BCLAF1 and THRAP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the Hakai family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03015356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601551.1">
        <property type="nucleotide sequence ID" value="XM_012746097.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F3I2"/>
    <dbReference type="SMR" id="A0A8B7F3I2"/>
    <dbReference type="Ensembl" id="ENSMICT00000044562.2">
        <property type="protein sequence ID" value="ENSMICP00000032339.2"/>
        <property type="gene ID" value="ENSMICG00000037843.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860927"/>
    <dbReference type="CTD" id="79872"/>
    <dbReference type="GeneTree" id="ENSGT00510000047522"/>
    <dbReference type="OrthoDB" id="547746at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045807">
        <property type="term" value="P:positive regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16508">
        <property type="entry name" value="RING-HC_HAKAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000140">
        <property type="entry name" value="E3 ubiquitin-protein ligase Hakai isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2210:FF:000001">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase hakai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040380">
        <property type="entry name" value="HAKAI-like_RING-HC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040383">
        <property type="entry name" value="HAKAI/CBLL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041042">
        <property type="entry name" value="Znf_Hakai"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13480:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HAKAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13480">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18408">
        <property type="entry name" value="zf_Hakai"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="21">
        <location>
            <begin position="109"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="255"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="399"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00079012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032339.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="491" mass="54556" checksum="FAF93BE8308C3FFE" modified="2022-01-19" version="1">MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQANKAKPAPRTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGELFGNQRRFPGHLFWDFQINILGEKDDTPVHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAEKPVTCASLENVHPPIAPPPTEIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPVPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F7P7</accession>
    <name>A0A8B7F7P7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Claudin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CLDN19</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell junction</location>
            <location evidence="8">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the claudin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001573">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603911.1">
        <property type="nucleotide sequence ID" value="XM_012748457.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F7P7"/>
    <dbReference type="Ensembl" id="ENSMICT00000046945.2">
        <property type="protein sequence ID" value="ENSMICP00000022443.1"/>
        <property type="gene ID" value="ENSMICG00000029190.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105862271"/>
    <dbReference type="KEGG" id="mmur:105862271"/>
    <dbReference type="CTD" id="149461"/>
    <dbReference type="GeneTree" id="ENSGT00940000158624"/>
    <dbReference type="OrthoDB" id="10025519at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097453">
        <property type="term" value="C:mesaxon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033010">
        <property type="term" value="C:paranodal junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043220">
        <property type="term" value="C:Schmidt-Lanterman incisure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098632">
        <property type="term" value="F:cell-cell adhesion mediator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160187">
        <property type="term" value="F:paracellular tight junction channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043297">
        <property type="term" value="P:apical junction assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019227">
        <property type="term" value="P:neuronal action potential propagation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160184">
        <property type="term" value="P:paracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150111">
        <property type="term" value="P:regulation of transepithelial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070293">
        <property type="term" value="P:renal absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003406">
        <property type="term" value="P:retinal pigment epithelium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120193">
        <property type="term" value="P:tight junction organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.150:FF:000001">
        <property type="entry name" value="Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006187">
        <property type="entry name" value="Claudin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017974">
        <property type="entry name" value="Claudin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004031">
        <property type="entry name" value="PMP22/EMP/MP20/Claudin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12002">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00822">
        <property type="entry name" value="PMP22_Claudin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01077">
        <property type="entry name" value="CLAUDIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01346">
        <property type="entry name" value="CLAUDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0796">Tight junction</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU060637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="224" mass="23279" checksum="A5614B0578905F00" modified="2022-01-19" version="1">MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPIAKGRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLCCTCPEPERVNSSPQPYRPGPSAAAREPVVKLPASAKGPLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FD16</accession>
    <name>A0A8B7FD16_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptotagmin-like protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Exophilin-7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SYTL1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001806">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606021.1">
        <property type="nucleotide sequence ID" value="XM_012750567.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606022.1">
        <property type="nucleotide sequence ID" value="XM_012750568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FD16"/>
    <dbReference type="Ensembl" id="ENSMICT00000015744.3">
        <property type="protein sequence ID" value="ENSMICP00000014343.3"/>
        <property type="gene ID" value="ENSMICG00000015733.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105863479"/>
    <dbReference type="CTD" id="84958"/>
    <dbReference type="GeneTree" id="ENSGT00940000160932"/>
    <dbReference type="OrthoDB" id="195679at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08393">
        <property type="entry name" value="C2A_SLP-1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04020">
        <property type="entry name" value="C2B_SLP_1-2-3-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000108">
        <property type="entry name" value="Synaptotagmin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000006">
        <property type="entry name" value="Synaptotagmin-like 5, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010911">
        <property type="entry name" value="Rab_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043567">
        <property type="entry name" value="SYTL1-5_C2B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716">
        <property type="entry name" value="BITESIZE, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45716:SF3">
        <property type="entry name" value="SYNAPTOTAGMIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50916">
        <property type="entry name" value="RABBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RabBD" evidence="12">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="333"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="465"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="109"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014343.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="629" mass="68655" checksum="86B44F1FC70A2736" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FFP1</accession>
    <name>A0A8B7FFP1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pleckstrin homology domain containing B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PLEKHB2</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011559">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607171.1">
        <property type="nucleotide sequence ID" value="XM_012751717.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607172.1">
        <property type="nucleotide sequence ID" value="XM_012751718.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FFP1"/>
    <dbReference type="Ensembl" id="ENSMICT00000037846.2">
        <property type="protein sequence ID" value="ENSMICP00000026862.1"/>
        <property type="gene ID" value="ENSMICG00000031046.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105864068"/>
    <dbReference type="KEGG" id="mmur:105864068"/>
    <dbReference type="CTD" id="55041"/>
    <dbReference type="GeneTree" id="ENSGT00390000013989"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045595">
        <property type="term" value="P:regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13265">
        <property type="entry name" value="PH_evt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000073">
        <property type="entry name" value="Pleckstrin homology domain-containing family B member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039680">
        <property type="entry name" value="PLEKHB1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14309:SF8">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="222" mass="24788" checksum="8CDD67C706AFFAA9" modified="2022-01-19" version="1">MAFVKSGWLLRQSTILKRWKKNWFDLWLDGHLIYYDDQTRQSIEDKVHMPVDCINIRTGHECRDIQPPDGKSKDCMLQIVCRDGKTISLCAESTDDCLAWKFTLQDSRTNTAYVGSAAMTDDTAVVSSPPPYTAYATPTPEQAYGYGPYGGVYPPGTQVVYAANGQAYAMPYQYPYAGLYGQQPTNQVIIRERYQDNDSDLALGMLAGAATGMALGSLFWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FLN2</accession>
    <name>A0A8B7FLN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Synaptic vesicle glycoprotein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SV2A</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003008">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609547.1">
        <property type="nucleotide sequence ID" value="XM_012754093.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FLN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000048846.2">
        <property type="protein sequence ID" value="ENSMICP00000030800.1"/>
        <property type="gene ID" value="ENSMICG00000000293.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865492"/>
    <dbReference type="KEGG" id="mmur:105865492"/>
    <dbReference type="CTD" id="9900"/>
    <dbReference type="GeneTree" id="ENSGT00950000182940"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098982">
        <property type="term" value="C:GABA-ergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031594">
        <property type="term" value="C:neuromuscular junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17439">
        <property type="entry name" value="MFS_SV2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000009">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000014">
        <property type="entry name" value="synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.80:FF:000001">
        <property type="entry name" value="Synaptic vesicle glycoprotein 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055415">
        <property type="entry name" value="LD_SV2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022308">
        <property type="entry name" value="SV2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01299">
        <property type="entry name" value="synapt_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF11">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23894">
        <property type="entry name" value="LD_SV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0770">Synapse</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="650"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="713"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="19">
        <location>
            <begin position="168"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="40"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037074"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038707"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040802"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="742" mass="82649" checksum="100D666963D7CA6D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FPH7</accession>
    <name>A0A8B7FPH7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TRMT6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021693">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610690.1">
        <property type="nucleotide sequence ID" value="XM_012755236.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FPH7"/>
    <dbReference type="SMR" id="A0A8B7FPH7"/>
    <dbReference type="Ensembl" id="ENSMICT00000011629.3">
        <property type="protein sequence ID" value="ENSMICP00000010581.1"/>
        <property type="gene ID" value="ENSMICG00000011626.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866070"/>
    <dbReference type="KEGG" id="mmur:105866070"/>
    <dbReference type="CTD" id="51605"/>
    <dbReference type="GeneTree" id="ENSGT00390000008327"/>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
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            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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            <end position="355"/>
        </location>
    </feature>
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        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="479"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="498" mass="56030" checksum="8D6A80D0B8DEB409" modified="2022-01-19" version="1">MENSGEQPGPQPPHPGDHRIRDGDFVVLKREDVFKAVQIQRRKKVTFEKQWFYLDNVIGHSYGTTFEVTSGGSLQPKKKKEEPTSETKEAGTDNRNIIDDGKSQKLTQDDIKALKDKGIKGEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIVTVVKPSTRILSIMYYAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLNGTFSAEMLSSEPKDSALAEESNGTLEEEKQTSEQENEDGMAETPEGSHPEEQEMMEIISQDAEHKEPKERGSKKDYIQEKQRRQEEQRKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADASLTSNSSTLESHKTEEPAAKKRKCPESDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FT06</accession>
    <name>A0A8B7FT06_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ARL15</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03016504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612200.1">
        <property type="nucleotide sequence ID" value="XM_012756746.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FT06"/>
    <dbReference type="Ensembl" id="ENSMICT00000069289.1">
        <property type="protein sequence ID" value="ENSMICP00000047957.1"/>
        <property type="gene ID" value="ENSMICG00000033364.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105867017"/>
    <dbReference type="CTD" id="54622"/>
    <dbReference type="GeneTree" id="ENSGT00940000156244"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04162">
        <property type="entry name" value="Arl9_Arfrp2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000934">
        <property type="entry name" value="ADP-ribosylation factor-like 15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042292">
        <property type="entry name" value="ARL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46693:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="22934" checksum="2739A4857500185A" modified="2022-01-19" version="1">MSDLRITEAFLYMDYLCFRALCCKGPPPARPEYDLVCIGLTGSGKTSLLSKLCSESPEEVVSTTGFSIKAVPFQNAILNVKELGGADNIRKYWSRYYQGSQGVIFVLDSASSEDDLETARNELHSALQHPQLCTLPFLILANHQDKPAARSVQEIKKYFELEPLARGKRWILQPCSLDNMDALKDSFSQLINVLEEKDHDVVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FV05</accession>
    <name>A0A8B7FV05_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP binding cassette subfamily D member 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="20">ATP-binding cassette sub-family D member 1 isoform X2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18 20" type="primary">ABCD1</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="20">Liver</tissue>
        </source>
    </reference>
    <reference evidence="18" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very long-chain fatty acid(in) + ATP + H2O = a very long-chain fatty acid(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67081"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very long-chain fatty acyl-CoA + H2O = a very long-chain fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67072"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:67073"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612660.1">
        <property type="nucleotide sequence ID" value="XM_012757206.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FV05"/>
    <dbReference type="Ensembl" id="ENSMICT00000003439.3">
        <property type="protein sequence ID" value="ENSMICP00000003129.1"/>
        <property type="gene ID" value="ENSMICG00000003441.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867309"/>
    <dbReference type="CTD" id="215"/>
    <dbReference type="GeneTree" id="ENSGT00950000182955"/>
    <dbReference type="OMA" id="CHRTSLW"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015607">
        <property type="term" value="F:ABC-type fatty-acyl-CoA transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036109">
        <property type="term" value="P:alpha-linolenic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901570">
        <property type="term" value="P:fatty acid derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055089">
        <property type="term" value="P:fatty acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042758">
        <property type="term" value="P:long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043217">
        <property type="term" value="P:myelin maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900016">
        <property type="term" value="P:negative regulation of cytokine production involved in inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903427">
        <property type="term" value="P:negative regulation of reactive oxygen species biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990535">
        <property type="term" value="P:neuron projection maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032000">
        <property type="term" value="P:positive regulation of fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001280">
        <property type="term" value="P:positive regulation of unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900407">
        <property type="term" value="P:regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051900">
        <property type="term" value="P:regulation of mitochondrial depolarization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002082">
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <name evidence="2" type="primary">LOC105867759</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017129">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012758107.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000039192.2"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="OSMOSIS RESPONSIVE FACTOR"/>
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        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 33"/>
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            <dbReference type="Ensembl" id="ENSMICP00000039192.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29240" checksum="73D031A43BFA8228" modified="2022-01-19" version="1">MASFGWKRKIGEKVSKVTSQQFEAEAADEKDVAENDEGNWLHAIKRRKVLLEGSAEKSKQLKDEGASLAENKRYREAIQKWDEALQLTPNDATLYEMKSQVLMSLHEMFPAVHAAEMAVQRNPHSWESWQTLGRAQLGLGERILAIRSFQVALHIHPMNPEIWKEDLSWARTLQEQQKVAQKIKKSEAPAEVAHFSPKSIPDYDFESDEIVAVCAAIAEKQKTVSANKTMVIVSASGTVETVTEKEDGATPPDGSVFIKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FX42</accession>
    <name>A0A8B7FX42_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Fibronectin leucine rich transmembrane protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">FLRT2</name>
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    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
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                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613913.1">
        <property type="nucleotide sequence ID" value="XM_012758459.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613922.1">
        <property type="nucleotide sequence ID" value="XM_012758468.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613939.1">
        <property type="nucleotide sequence ID" value="XM_012758485.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000069000.1">
        <property type="protein sequence ID" value="ENSMICP00000049888.1"/>
        <property type="gene ID" value="ENSMICG00000046698.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105867985"/>
    <dbReference type="KEGG" id="mmur:105867985"/>
    <dbReference type="CTD" id="23768"/>
    <dbReference type="GeneTree" id="ENSGT00940000158937"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:focal adhesion"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Leucine-rich repeat transmembrane protein FLRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cys-rich_flank_reg_C"/>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="Leu-rich_rpt"/>
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        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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        <property type="entry name" value="LRRNT"/>
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        <property type="entry name" value="SLRP"/>
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    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF16">
        <property type="entry name" value="LEUCINE-RICH REPEAT TRANSMEMBRANE PROTEIN FLRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01463">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
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    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="14" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 21" id="KW-0732">Signal</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133688" evidence="21">
        <location>
            <begin position="36"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="22">
        <location>
            <begin position="419"/>
            <end position="517"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="373"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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            <dbReference type="SAM" id="SignalP"/>
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    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="661" mass="73871" checksum="5674E6CD144105A4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GD72</accession>
    <name>A0A8B7GD72_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Interferon induced protein with tetratricopeptide repeats 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">IFIT2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the IFIT family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620593.1">
        <property type="nucleotide sequence ID" value="XM_012765139.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GD72"/>
    <dbReference type="Ensembl" id="ENSMICT00000047222.2">
        <property type="protein sequence ID" value="ENSMICP00000030636.1"/>
        <property type="gene ID" value="ENSMICG00000036288.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871680"/>
    <dbReference type="KEGG" id="mmur:105871680"/>
    <dbReference type="CTD" id="3433"/>
    <dbReference type="GeneTree" id="ENSGT00950000182946"/>
    <dbReference type="OrthoDB" id="10043504at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000036">
        <property type="entry name" value="interferon-induced protein with tetratricopeptide repeats 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10271:SF4">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="1" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="243"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="480" mass="55818" checksum="EFA913197E2D8DEB" modified="2022-01-19" version="1">MSETTQNSLESSLQQLKCHFTWNLLEGENSLDDFEDKVLYRTEFQNSDFKATTHNLLAYIKHCRGQNEAALECLRQAEESIRQEHADQAEMRSLVTWGNYAWVYYHMGRLSEAQIYVDKVKHVCEKFSSPYRIESPELHCEEGWARLKCGGKQNERAKVCFKKALEKNPKNPEFTSGLAISSYRLDNWPPSQDPVDPLRQAIRLDPDNQYIKVLLALKLHKMNKEGEGEKLVEEALAKAPGATDVLRSAAQLYRRKNDPDKAIELLRKALEYMPNNAYLHYQIGGCYRAKVHDIMKVGDDIIKREELLELIRQAVAHFKIADETNENLFRVCSVLAILHSLVHQNEEAEYYFQKEFSKEHSPIEKQVLHLRYGNFQLYQMKCEDMAIHHFLEGVKINQKSKVTEKMKNKLQKIAKMRLSKNREDSEALHILEFLQELSEETQQADENSEKGLDSGRLILSETLAETENEELEIRCPWSYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GFA0</accession>
    <name>A0A8B7GFA0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S ribosomal protein L23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">RPL23</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621394.1">
        <property type="nucleotide sequence ID" value="XM_012765940.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GFA0"/>
    <dbReference type="SMR" id="A0A8B7GFA0"/>
    <dbReference type="Ensembl" id="ENSMICT00000053890.2">
        <property type="protein sequence ID" value="ENSMICP00000033514.2"/>
        <property type="gene ID" value="ENSMICG00000036519.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105872126"/>
    <dbReference type="KEGG" id="mmur:105872126"/>
    <dbReference type="CTD" id="9349"/>
    <dbReference type="GeneTree" id="ENSGT00390000004690"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006344">
        <property type="entry name" value="PRK08571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033514.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="140" mass="14865" checksum="807E14139B2EB0B5" modified="2022-01-19" version="1">MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDMVMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGPVAKECADLWPRIASNAGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GIB8</accession>
    <name>A0A8B7GIB8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">OR5H2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GIB8"/>
    <dbReference type="Ensembl" id="ENSMICT00000073131.1">
        <property type="protein sequence ID" value="ENSMICP00000050834.1"/>
        <property type="gene ID" value="ENSMICG00000049319.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105872745"/>
    <dbReference type="GeneTree" id="ENSGT01120000271834"/>
    <dbReference type="OrthoDB" id="9615015at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1220.70:FF:000001">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11 12" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="14">
        <location>
            <begin position="46"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="35598" checksum="70607C9AAD129CE3" modified="2022-01-19" version="1">MCSEDMKTENATVLTEFVLTGLTYQSQWKIPLFLAFLVIYLITMVGNLGLITLIRNGPHLHIPMYLFLGSLAFVDAWISSTVTPKMLVNFLAKSQIMTLSECLIQFFSFAFGGTTECFLLAAMAYDRYVAICKPLLYPVIMTNELCIRLLVLSFVGGFLHALIHDVLIFRLTFCNSNIIHHFYCDIIPLFMISCTDPSINFLMVFILSGSIQIFSIVTILNSYTFILITILKKKSVEGIRKAFSTCGAHLLSVSLYYGPLLFMYVRPASPETEDQDMMDSLFYTVIIPLLNPIIYSLRNKQVIDSLSKMLKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GQD5</accession>
    <name>A0A8B7GQD5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring finger protein 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RNF38</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625392.1">
        <property type="nucleotide sequence ID" value="XM_012769938.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625400.1">
        <property type="nucleotide sequence ID" value="XM_012769946.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625402.1">
        <property type="nucleotide sequence ID" value="XM_012769948.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625403.1">
        <property type="nucleotide sequence ID" value="XM_012769949.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625404.1">
        <property type="nucleotide sequence ID" value="XM_012769950.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625405.1">
        <property type="nucleotide sequence ID" value="XM_012769951.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625406.1">
        <property type="nucleotide sequence ID" value="XM_012769952.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625407.1">
        <property type="nucleotide sequence ID" value="XM_012769953.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GQD5"/>
    <dbReference type="Ensembl" id="ENSMICT00000053831.2">
        <property type="protein sequence ID" value="ENSMICP00000026922.2"/>
        <property type="gene ID" value="ENSMICG00000017677.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874282"/>
    <dbReference type="KEGG" id="mmur:105874282"/>
    <dbReference type="CTD" id="152006"/>
    <dbReference type="GeneTree" id="ENSGT00940000156228"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16679">
        <property type="entry name" value="RING-H2_RNF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000024">
        <property type="entry name" value="RING finger protein 44 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46171">
        <property type="entry name" value="GH10160P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="380"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026922.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="432" mass="48548" checksum="E3118EE4FDB4BE26" modified="2022-01-19" version="1">MRPWEMTSNRQPPSVRPSQHHFSGERCNTPARNRRSPPVRRQRGRRDRLSRHNSVSQDENYHHLPYAQQQAIEEPRAFHPPNVSPRLLHPAAHPPQQNAVMVDIHDQLHQGTVPVSYTVTTVAPHGIPLCTGQHIPACSTQQVPGCSVVFSGQHLPVCSVPPPMLQACSVQHLPVPYAAFPPLISSDPFLIHPPHLSPHHPPHLPPPGQFVPFQTQQSRSPLQRIENEVELLGEHLPVGGFTYPPSAHPPTLPPSAPLQFLTHDPLHQEVSFGVPYPPFMPRRLTGRSRYRSQQPIPPPPYHPSLLPYVLSMLPVPPAVGPTFSFELDVEDGEVENYEALLNLAERLGEAKPRGLTKADIEQLPSYRFNPNNHQSEQTLCVVCMCDFESRQLLRVLPCNHEFHAKCVDKWLKANRTCPICRADASEVHRDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GQX6</accession>
    <name>A0A8B7GQX6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable ATP-dependent RNA helicase DHX40</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DEAH box protein 40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DHX40</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable ATP-dependent RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03020015">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020016">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625473.1">
        <property type="nucleotide sequence ID" value="XM_012770019.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GQX6"/>
    <dbReference type="Ensembl" id="ENSMICT00000035089.2">
        <property type="protein sequence ID" value="ENSMICP00000031426.2"/>
        <property type="gene ID" value="ENSMICG00000027647.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874292"/>
    <dbReference type="KEGG" id="mmur:105874292"/>
    <dbReference type="CTD" id="79665"/>
    <dbReference type="GeneTree" id="ENSGT00940000158902"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17984">
        <property type="entry name" value="DEXHc_DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000009">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001082">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF271">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX40-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="63"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="263"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="740"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00083342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031426.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="779" mass="88512" checksum="772717F6D601D2B7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GRD5</accession>
    <name>A0A8B7GRD5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein 42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TMEM42</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018117">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625800.1">
        <property type="nucleotide sequence ID" value="XM_012770346.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GRD5"/>
    <dbReference type="Ensembl" id="ENSMICT00000037061.2">
        <property type="protein sequence ID" value="ENSMICP00000029704.1"/>
        <property type="gene ID" value="ENSMICG00000033990.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874464"/>
    <dbReference type="KEGG" id="mmur:105874464"/>
    <dbReference type="CTD" id="131616"/>
    <dbReference type="GeneTree" id="ENSGT00390000012690"/>
    <dbReference type="OrthoDB" id="5854584at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039632">
        <property type="entry name" value="TMEM42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31965:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="159" mass="17039" checksum="4C5A5EE550447F77" modified="2022-01-19" version="1">MAVRPQPPGGAVAATAYPDTPVEFPPYLQAGAMRRRFWGVFNCLCAGAFGALAAASAKLAFGSEVNVGLSVLGIIVMASTNSLMWTFFSRGLSFSMSSAIASVTVTFSNILSSAFLGYVLYGECQEVLWWGGVFLILCGLTLIHRKLPPTWKSLPHKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GY59</accession>
    <name>A0A8B7GY59_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">ATP-binding cassette sub-family C member 10</fullName>
            <ecNumber evidence="3">7.6.2.2</ecNumber>
            <ecNumber evidence="15">7.6.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Multidrug resistance-associated protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">ABCC10</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60128"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:82961"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:60129"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2.</text>
            <dbReference type="EC" id="7.6.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19121"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.6.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:19122"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>leukotriene C4(in) + ATP + H2O = leukotriene C4(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38964"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Basal cell membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Basolateral cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.2" evidence="3"/>
    <dbReference type="EC" id="7.6.2.3" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03007536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628570.1">
        <property type="nucleotide sequence ID" value="XM_012773116.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628571.1">
        <property type="nucleotide sequence ID" value="XM_012773117.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000004988.3">
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        <source>
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    <sequence length="1490" mass="161762" checksum="A594F62BBFDF7FE5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H1V1</accession>
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        <recommendedName>
            <fullName evidence="11">Ras and Rab interactor-like protein</fullName>
        </recommendedName>
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        <name evidence="14" type="primary">RINL</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with RAB5A, RAB22A and MUSK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Ruffle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012774682.2"/>
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        <property type="nucleotide sequence ID" value="XM_012774685.1"/>
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        <property type="nucleotide sequence ID" value="XM_012774687.1"/>
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        <property type="nucleotide sequence ID" value="XM_012774688.1"/>
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        <property type="nucleotide sequence ID" value="XM_012774689.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7H1V1"/>
    <dbReference type="Ensembl" id="ENSMICT00000070964.1">
        <property type="protein sequence ID" value="ENSMICP00000045323.1"/>
        <property type="gene ID" value="ENSMICG00000042105.1"/>
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    <dbReference type="GeneID" id="105876812"/>
    <dbReference type="KEGG" id="mmur:105876812"/>
    <dbReference type="CTD" id="126432"/>
    <dbReference type="GeneTree" id="ENSGT00940000162381"/>
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        <property type="component" value="Chromosome 22"/>
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    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0001726">
        <property type="term" value="C:ruffle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000012">
        <property type="entry name" value="Ras and Rab interactor like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF72">
        <property type="entry name" value="RAS AND RAB INTERACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23268">
        <property type="entry name" value="RIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS9" evidence="13">
        <location>
            <begin position="365"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="553" mass="60576" checksum="4BF988C88C462AFD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H4Q2</accession>
    <name>A0A8B7H4Q2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase 21 kDa proteolipid subunit c''</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Vacuolar proton pump 21 kDa proteolipid subunit c''</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ATP6V0B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with IFITM3. Interacts with TM4SF19; this interaction inhibits V1-V0 complex assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasmic vesicle</location>
            <location evidence="8">Clathrin-coated vesicle membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001561">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631358.1">
        <property type="nucleotide sequence ID" value="XM_012775904.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H4Q2"/>
    <dbReference type="Ensembl" id="ENSMICT00000064715.1">
        <property type="protein sequence ID" value="ENSMICP00000045013.1"/>
        <property type="gene ID" value="ENSMICG00000011028.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877430"/>
    <dbReference type="KEGG" id="mmur:105877430"/>
    <dbReference type="CTD" id="533"/>
    <dbReference type="GeneTree" id="ENSGT00550000075120"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="52"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="14">
        <location>
            <begin position="138"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00062646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="205" mass="21494" checksum="1E12987B83EB2BDB" modified="2022-01-19" version="1">MTGLALLYSGVFVAFWACMVVVGICYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPQAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H4U0</accession>
    <name>A0A8B7H4U0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">KIF2C</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631415.1">
        <property type="nucleotide sequence ID" value="XM_012775961.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H4U0"/>
    <dbReference type="Ensembl" id="ENSMICT00000060642.1">
        <property type="protein sequence ID" value="ENSMICP00000049551.1"/>
        <property type="gene ID" value="ENSMICG00000008003.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877446"/>
    <dbReference type="KEGG" id="mmur:105877446"/>
    <dbReference type="CTD" id="11004"/>
    <dbReference type="GeneTree" id="ENSGT00940000154046"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099188">
        <property type="term" value="P:postsynaptic cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051983">
        <property type="term" value="P:regulation of chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098696">
        <property type="term" value="P:regulation of neurotransmitter receptor localization to postsynaptic specialization membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000006">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054473">
        <property type="entry name" value="KIF2A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF25">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22923">
        <property type="entry name" value="KIF2A-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="17" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7 21" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="20 21" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="24">
        <location>
            <begin position="258"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="348"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="725" mass="81289" checksum="99B13F00FB860B65" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H6X1</accession>
    <name>A0A8B7H6X1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="9">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF5A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eIF-5A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020559">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632215.1">
        <property type="nucleotide sequence ID" value="XM_012776761.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632223.1">
        <property type="nucleotide sequence ID" value="XM_012776769.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632232.1">
        <property type="nucleotide sequence ID" value="XM_012776778.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632241.1">
        <property type="nucleotide sequence ID" value="XM_012776787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H6X1"/>
    <dbReference type="SMR" id="A0A8B7H6X1"/>
    <dbReference type="Ensembl" id="ENSMICT00000036395.2">
        <property type="protein sequence ID" value="ENSMICP00000023091.1"/>
        <property type="gene ID" value="ENSMICG00000028821.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105877825"/>
    <dbReference type="CTD" id="1984"/>
    <dbReference type="GeneTree" id="ENSGT00390000003738"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0385">Hypusine</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="10">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="154" mass="16832" checksum="07EF043C7DEA3091" modified="2022-01-19" version="1">MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HDE5</accession>
    <name>A0A8B7HDE5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Semaphorin-3C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SEMA3C</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with PLXND1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015412">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634956.1">
        <property type="nucleotide sequence ID" value="XM_012779502.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634957.1">
        <property type="nucleotide sequence ID" value="XM_012779503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HDE5"/>
    <dbReference type="Ensembl" id="ENSMICT00000030903.2">
        <property type="protein sequence ID" value="ENSMICP00000018051.1"/>
        <property type="gene ID" value="ENSMICG00000031169.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879344"/>
    <dbReference type="KEGG" id="mmur:105879344"/>
    <dbReference type="CTD" id="10512"/>
    <dbReference type="GeneTree" id="ENSGT00940000159379"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001974">
        <property type="term" value="P:blood vessel remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140074">
        <property type="term" value="P:cardiac endothelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003215">
        <property type="term" value="P:cardiac right ventricle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060666">
        <property type="term" value="P:dichotomous subdivision of terminal units involved in salivary gland branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060174">
        <property type="term" value="P:limb bud formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021915">
        <property type="term" value="P:neural tube development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003148">
        <property type="term" value="P:outflow tract septum morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905312">
        <property type="term" value="P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003350">
        <property type="term" value="P:pulmonary myocardium development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05871">
        <property type="entry name" value="Ig_Sema3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11251">
        <property type="entry name" value="Sema_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000123">
        <property type="entry name" value="Semaphorin 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000001">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF25">
        <property type="entry name" value="SEMAPHORIN-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134082" description="Semaphorin-3C" evidence="18">
        <location>
            <begin position="22"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="20">
        <location>
            <begin position="28"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="19">
        <location>
            <begin position="590"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="711"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00057669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="751" mass="85021" checksum="4CF0532177006ADF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HF44</accession>
    <name>A0A8B7HF44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">SIK1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03033302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634552.1">
        <property type="nucleotide sequence ID" value="XM_012779098.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634553.1">
        <property type="nucleotide sequence ID" value="XM_012779099.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HF44"/>
    <dbReference type="Ensembl" id="ENSMICT00000038458.2">
        <property type="protein sequence ID" value="ENSMICP00000021904.1"/>
        <property type="gene ID" value="ENSMICG00000000552.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879113"/>
    <dbReference type="KEGG" id="mmur:105879113"/>
    <dbReference type="CTD" id="150094"/>
    <dbReference type="GeneTree" id="ENSGT00940000154989"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071889">
        <property type="term" value="F:14-3-3 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008140">
        <property type="term" value="F:cAMP response element binding protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043276">
        <property type="term" value="P:anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010868">
        <property type="term" value="P:negative regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000210">
        <property type="term" value="P:positive regulation of anoikis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010830">
        <property type="term" value="P:regulation of myotube differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000154">
        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF47">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SIK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="299"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="775" mass="83802" checksum="B3472C1CE1961A43" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HIW5</accession>
    <name>A0A8B7HIW5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Peripheral plasma membrane protein CASK</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Calcium/calmodulin-dependent serine protein kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">CASK</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MAGUK family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03036445">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036448">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036449">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036450">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637296.1">
        <property type="nucleotide sequence ID" value="XM_012781842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HIW5"/>
    <dbReference type="SMR" id="A0A8B7HIW5"/>
    <dbReference type="Ensembl" id="ENSMICT00000052523.2">
        <property type="protein sequence ID" value="ENSMICP00000017683.1"/>
        <property type="gene ID" value="ENSMICG00000000276.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880647"/>
    <dbReference type="CTD" id="8573"/>
    <dbReference type="GeneTree" id="ENSGT00940000155600"/>
    <dbReference type="OrthoDB" id="65789at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005604">
        <property type="term" value="C:basement membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005652">
        <property type="term" value="C:nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042043">
        <property type="term" value="F:neurexin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070509">
        <property type="term" value="P:calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001953">
        <property type="term" value="P:negative regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090288">
        <property type="term" value="P:negative regulation of cellular response to growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010839">
        <property type="term" value="P:negative regulation of keratinocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061045">
        <property type="term" value="P:negative regulation of wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090280">
        <property type="term" value="P:positive regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10831">
        <property type="entry name" value="PDZ_CASK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12081">
        <property type="entry name" value="SH3_CASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14094">
        <property type="entry name" value="STKc_CASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000146">
        <property type="entry name" value="MAGUK p55 subfamily member 6 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000051">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000062">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000080">
        <property type="entry name" value="Peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000016">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000004">
        <property type="entry name" value="peripheral plasma membrane protein CASK isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.650">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035473">
        <property type="entry name" value="CASK_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014775">
        <property type="entry name" value="L27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004172">
        <property type="entry name" value="L27_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036892">
        <property type="entry name" value="L27_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050716">
        <property type="entry name" value="MAGUK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23122">
        <property type="entry name" value="MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02828">
        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
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    <dbReference type="SUPFAM" id="SSF101288">
        <property type="entry name" value="L27 domain"/>
        <property type="match status" value="2"/>
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    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L27"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 24" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="30">
        <location>
            <begin position="343"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="L27" evidence="30">
        <location>
            <begin position="402"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="29">
        <location>
            <begin position="490"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="26">
        <location>
            <begin position="612"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="28">
        <location>
            <begin position="739"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="574"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00060907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00071925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00077072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="926" mass="105123" checksum="6C02008CE52728BA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HNZ0</accession>
    <name>A0A8B7HNZ0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zinc finger protein 143</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Selenocysteine tRNA gene transcription-activating factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF143</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Interacts with CHD8. Forms a complex with HCFC1 and ZNF143.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLI C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006393">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006394">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639469.1">
        <property type="nucleotide sequence ID" value="XM_012784015.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639470.1">
        <property type="nucleotide sequence ID" value="XM_012784016.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639471.1">
        <property type="nucleotide sequence ID" value="XM_012784017.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639472.1">
        <property type="nucleotide sequence ID" value="XM_012784018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HNZ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000059591.1">
        <property type="protein sequence ID" value="ENSMICP00000043369.1"/>
        <property type="gene ID" value="ENSMICG00000004353.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881975"/>
    <dbReference type="KEGG" id="mmur:105881975"/>
    <dbReference type="CTD" id="7702"/>
    <dbReference type="GeneTree" id="ENSGT00940000157584"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006359">
        <property type="term" value="P:regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000071">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000125">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000137">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000142">
        <property type="entry name" value="Putative zinc finger protein 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000236">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="267"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="357"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="387"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="417"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="638" mass="68893" checksum="A08E1A2FBEFE03B3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HRR7</accession>
    <name>A0A8B7HRR7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450 2J2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CYP2J89</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001431">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HRR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000059984.1">
        <property type="protein sequence ID" value="ENSMICP00000046001.1"/>
        <property type="gene ID" value="ENSMICG00000013472.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155417"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20662">
        <property type="entry name" value="CYP2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000004">
        <property type="entry name" value="cytochrome P450 2D15 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008071">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP2J-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050182">
        <property type="entry name" value="Cytochrome_P450_fam2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300:SF177">
        <property type="entry name" value="CYTOCHROME P450 2J2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24300">
        <property type="entry name" value="CYTOCHROME P450 508A4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01688">
        <property type="entry name" value="EP450ICYP2J"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0492">Microsome</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="57002" checksum="4B84E95B48973EB7" modified="2022-01-19" version="1">MGSLAAALWALLHPQTLLLGAVTFLLFADFLKRQRRKNYPPGPWRLPFFGNFFHLDLEQSQLALKRLVKKYGNLIGLEFGPISTVVITGLPLIKEALVHMDQHFMNRPVFPLQEHIVKGNGLIMSNGQVWKEQRRFALTALRNFGLGKKSLEERIQEEVRHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGKRFEYQDAQFQELLGLLDEVSYMSGSVSCQLYNFFPWIMKFIPGSHRTVIKNWEKLKLFVSQMIEKHKKDWNPDETRDFIDAYLKEMAKNAEKPTSSFHEDNLIISTLDLFFAGTETTSTTLRWALLYLALHPEIQEKVHAEIDTVIGQEQQPSVAARNSMPYTNAVIHEVQRMGNIVPLNVPREVTADTTLAGYHLPKGTMIMTNLTALHRDPTEWATPDAFNPEHFLENGQFKKSESFLPFSIGKRACLGEQLAKSELFIFFTSLMQKFTFRPPENEKLSLKCRMGITVSPVKHRLCAVPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HVF9</accession>
    <name>A0A8B7HVF9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nedd4 family interacting protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">NDFIP2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03017434">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641219.1">
        <property type="nucleotide sequence ID" value="XM_012785765.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145883.1">
        <property type="nucleotide sequence ID" value="XM_020290294.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HVF9"/>
    <dbReference type="Ensembl" id="ENSMICT00000030629.2">
        <property type="protein sequence ID" value="ENSMICP00000037813.1"/>
        <property type="gene ID" value="ENSMICG00000026359.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105882977"/>
    <dbReference type="KEGG" id="mmur:105882977"/>
    <dbReference type="CTD" id="54602"/>
    <dbReference type="GeneTree" id="ENSGT00390000012721"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEDD4/Bsd2"/>
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        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF4">
        <property type="entry name" value="NEDD4 FAMILY-INTERACTING PROTEIN 2"/>
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        <property type="entry name" value="NEDD4_Bsd2"/>
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            <end position="255"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="336" mass="36559" checksum="2A9C6C7293D111C2" modified="2022-01-19" version="1">MGRRRSHRVCAATPSMLSSARGAPELLHRAAADAELFAAAAGATGSEAAPPGHCGGRTRGGRGAAAATSLTRVAEGAARRGDSLARKPDPEPDRMDHHQPGTGRYQVLHNEEDNSESSAVEQPSTSNSSPQDVQTAPSASALETDSSPPPYSSITVEVPTSSDSEVYSEFYPVPPPYSVATSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDDFSDADQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HZ02</accession>
    <name>A0A8B7HZ02_MICMU</name>
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            <fullName evidence="9">ESX homeobox 1</fullName>
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        <name evidence="9" type="primary">ESX1</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Mammalia</taxon>
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            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I590</accession>
    <name>A0A8B7I590_MICMU</name>
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        <submittedName>
            <fullName evidence="5">Chromosome 19 open reading frame 38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">C19orf38</name>
        <name evidence="5" type="synonym">C24H19orf38</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027838">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I590"/>
    <dbReference type="Ensembl" id="ENSMICT00000060049.1">
        <property type="protein sequence ID" value="ENSMICP00000044134.1"/>
        <property type="gene ID" value="ENSMICG00000044532.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885574"/>
    <dbReference type="GeneTree" id="ENSGT00390000008862"/>
    <dbReference type="OrthoDB" id="9219586at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041066">
        <property type="entry name" value="C19orf38_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040438">
        <property type="entry name" value="HIDE1"/>
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    <dbReference type="PANTHER" id="PTHR36859">
        <property type="entry name" value="PROTEIN HIDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36859:SF1">
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134252" evidence="3">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="229" mass="24633" checksum="08700892E1224479" modified="2022-01-19" version="1">MPWTVLLFAAGSLAIPAPSILLVPPHPSSQEDPIYISCVAPESFLGANFTLYRGGHMVQRLQAPADHRGVTFNLSGGSSEAPGGPFHCQYGVMGEHSEPQLSDLSAPVHVRFPVPTWILALSLSLAGTFFLLAGLATLAVVVRKVRVKHLQRKRDQESCWAQINFANTDMSFDNSLFAVSKMTSEEDSATPDARSGTTVIPGHSGARKRPTSTSSSPEPPEFSTFRACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X5L4</accession>
    <name>A0A8B7X5L4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Adhesion G-protein coupled receptor G6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Developmentally regulated G-protein-coupled receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">G-protein coupled receptor 126</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="primary">ADGRG6</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with Laminin-2; this interaction stabilizes the receptor in an inactive state. Laminin-2 polymerization could facilitate ADGRG6-NTF removal, thereby exposing the tethered agonist to drive myelination. Interacts with PRNP. Interacts with ITGB1. Interacts with LRP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008484">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_020287235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X5L4"/>
    <dbReference type="Ensembl" id="ENSMICT00000010203.3">
        <property type="protein sequence ID" value="ENSMICP00000009290.3"/>
        <property type="gene ID" value="ENSMICG00000010198.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065114.1">
        <property type="protein sequence ID" value="ENSMICP00000048413.1"/>
        <property type="gene ID" value="ENSMICG00000010198.3"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00940000155621"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043236">
        <property type="term" value="F:laminin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:cell surface receptor signaling pathway"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:heart trabecula formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:myelination in peripheral nervous system"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CUB"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ConA-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR058857">
        <property type="entry name" value="GAIN_ADGRG2/6"/>
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    <dbReference type="InterPro" id="IPR057244">
        <property type="entry name" value="GAIN_B"/>
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    <dbReference type="InterPro" id="IPR046338">
        <property type="entry name" value="GAIN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
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        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000203">
        <property type="entry name" value="GPS"/>
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        <property type="entry name" value="SEA_Gpr126"/>
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        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADHESION G-PROTEIN COUPLED RECEPTOR G6"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Pentaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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        <property type="entry name" value="PTX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 22" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 25" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665420" description="Adhesion G-protein coupled receptor G6" evidence="25">
        <location>
            <begin position="38"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="865"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="900"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="932"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="969"/>
            <end position="990"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1018"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1069"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1094"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="CUB" evidence="26">
        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Pentraxin (PTX)" evidence="29">
        <location>
            <begin position="154"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="GAIN-B" evidence="27">
        <location>
            <begin position="669"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="28">
        <location>
            <begin position="863"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1155"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1181"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="1190"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="22">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00080676"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00082039"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00093343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00093532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1249" mass="139291" checksum="E4ECF32ACDB5F454" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X928</accession>
    <name>A0A8B7X928_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="21">ArfGAP with SH3 domain, ankyrin repeat and PH domain 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ASAP2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03012154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144257.1">
        <property type="nucleotide sequence ID" value="XM_020288668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X928"/>
    <dbReference type="Ensembl" id="ENSMICT00000002352.3">
        <property type="protein sequence ID" value="ENSMICP00000002151.2"/>
        <property type="gene ID" value="ENSMICG00000002345.3"/>
    </dbReference>
    <dbReference type="CTD" id="8853"/>
    <dbReference type="GeneTree" id="ENSGT00940000155623"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08849">
        <property type="entry name" value="ArfGap_ASAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07642">
        <property type="entry name" value="BAR_ASAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13251">
        <property type="entry name" value="PH_ASAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11966">
        <property type="entry name" value="SH3_ASAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000002">
        <property type="entry name" value="arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000004">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.950:FF:000001">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000006">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000012">
        <property type="entry name" value="Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043593">
        <property type="entry name" value="ASAP"/>
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    <dbReference type="InterPro" id="IPR035677">
        <property type="entry name" value="ASAP2_SH3"/>
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    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037844">
        <property type="entry name" value="PH_ASAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854:SF4">
        <property type="entry name" value="ARF-GAP WITH SH3 DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45854">
        <property type="entry name" value="ASAP FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="19">
        <location>
            <begin position="305"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="20">
        <location>
            <begin position="421"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="620"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="18">
        <location>
            <begin position="899"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="284"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="764"/>
            <end position="899"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="287"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="816"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="830"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002151.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="961" mass="107041" checksum="903B4C49453164D8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XAB0</accession>
    <name>A0A8B7XAB0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Hexosyltransferase</fullName>
            <ecNumber evidence="17">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">B3GALT1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = a beta-D-Gal-(1-&gt;3)-beta-D-GlcNAc-(1-&gt;3)-beta-D-Gal-(1-&gt;4)-beta-D-Glc-(1&lt;-&gt;1')-Cer(d18:1(4E)) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16045"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17103"/>
            <dbReference type="ChEBI" id="CHEBI:17292"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.86"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:16046"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1-&gt;3)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61631"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:133506"/>
            <dbReference type="EC" id="2.4.1.86"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:53433"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Golgi apparatus membrane</location>
            <topology evidence="2 17">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03011116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143993.1">
        <property type="nucleotide sequence ID" value="XM_020288404.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143994.1">
        <property type="nucleotide sequence ID" value="XM_020288405.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143995.1">
        <property type="nucleotide sequence ID" value="XM_020288406.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XAB0"/>
    <dbReference type="Ensembl" id="ENSMICT00000059207.1">
        <property type="protein sequence ID" value="ENSMICP00000043283.1"/>
        <property type="gene ID" value="ENSMICG00000042176.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105867221"/>
    <dbReference type="KEGG" id="mmur:105867221"/>
    <dbReference type="CTD" id="8708"/>
    <dbReference type="GeneTree" id="ENSGT00940000156219"/>
    <dbReference type="OMA" id="MPRDVYP"/>
    <dbReference type="OrthoDB" id="5957813at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008499">
        <property type="term" value="F:N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006682">
        <property type="term" value="P:galactosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009312">
        <property type="term" value="P:oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000001">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF20">
        <property type="entry name" value="BETA-1,3-GALACTOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="38007" checksum="55FC732F7E9FBDC4" modified="2022-01-19" version="1">MASKVSCLYVLTVVCWASALWYLSITRPTSSYTGSKPFSHLTVARKNFTFGNIRTRPINPHSFEFLINEPNKCEKNIPFLVILISTTHKEFDARQAIRETWGDENNFKGIKIATLFLLGKNADPVLNQMVEQESQIFHDIIVEDFIDSYHNLTLKTLMGMRWVATFCSKAKYVMKTDSDIFVNMDNLIYKLLKPSTKPRRRYFTGYVINGGPIRDIRSKWYMPRDLYPDSNYPPFCSGTGYIFSADVAELIYKTSLHTRLLHLEDVYVGLCLRKLGIHPFQNSGFNHWKMAYSLCRYRRVITVHQISPEEMHRIWNDMSSKKHLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UK33</accession>
    <name>A0A8C5UK33_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Pleckstrin homology domain-containing family E member 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Suprachiasmatic nucleus circadian oscillatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">PHLPP1</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
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            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03022308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000001572.3">
        <property type="protein sequence ID" value="ENSMICP00000001428.3"/>
        <property type="gene ID" value="ENSMICG00000001559.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158137"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051898">
        <property type="term" value="P:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046328">
        <property type="term" value="P:regulation of JNK cascade"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900744">
        <property type="term" value="P:regulation of p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002667">
        <property type="term" value="P:regulation of T cell anergy"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13322">
        <property type="entry name" value="PH_PHLPP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17240">
        <property type="entry name" value="RA_PHLPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000278">
        <property type="entry name" value="PH domain and leucine rich repeat protein phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000345">
        <property type="entry name" value="PH domain and leucine rich repeat protein phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000027">
        <property type="entry name" value="PH domain and leucine rich repeat protein phosphatase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000003">
        <property type="entry name" value="PH domain and leucine-rich repeat protein phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
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        <property type="entry name" value="LRR_dom_sf"/>
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    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
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    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
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    <dbReference type="PANTHER" id="PTHR48051:SF43">
        <property type="entry name" value="PH DOMAIN AND LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 1"/>
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    </dbReference>
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        <property type="entry name" value="RA_3"/>
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    </dbReference>
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        <property type="entry name" value="LRR_BAC"/>
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    </dbReference>
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        <property type="entry name" value="LRR_TYP"/>
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    </dbReference>
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        <property type="entry name" value="PP2Cc"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
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    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="350"/>
            <end position="450"/>
        </location>
    </feature>
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            <begin position="989"/>
            <end position="1236"/>
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            <begin position="1463"/>
            <end position="1536"/>
        </location>
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            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
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            <begin position="172"/>
            <end position="184"/>
        </location>
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            <begin position="218"/>
            <end position="229"/>
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    </feature>
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            <end position="1520"/>
        </location>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00077797"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00080105"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51746"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001428.3"/>
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    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="4">Secretoglobin family 2A member 1</fullName>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005837">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNI9"/>
    <dbReference type="Ensembl" id="ENSMICT00000003201.3">
        <property type="protein sequence ID" value="ENSMICP00000002905.2"/>
        <property type="gene ID" value="ENSMICG00000003206.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105878667"/>
    <dbReference type="GeneTree" id="ENSGT00390000013802"/>
    <dbReference type="OrthoDB" id="9741516at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030521">
        <property type="term" value="P:androgen receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00633">
        <property type="entry name" value="Secretoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016126">
        <property type="entry name" value="Secretoglobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035960">
        <property type="entry name" value="Secretoglobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14037:SF4">
        <property type="entry name" value="MAMMAGLOBIN-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14037">
        <property type="entry name" value="MAMMAGLOBIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01099">
        <property type="entry name" value="Uteroglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48201">
        <property type="entry name" value="Uteroglobin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51311">
        <property type="entry name" value="SCGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149852" evidence="3">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002905.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="93" mass="10620" checksum="31ABEB56938A6711" modified="2022-01-19" version="1">MKLLTVLLLVALPLYCSAGSGCQQLENIVAKTLDPDISVDDFKNYLKEYIDNERSSEAVGEFKQCFLKQSDETLKNFGEMMQIIYDSPWCKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNJ0</accession>
    <name>A0A8C5UNJ0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Zinc finger protein with KRAB and SCAN domains 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ZKSCAN1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNJ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000003952.3">
        <property type="protein sequence ID" value="ENSMICP00000003601.2"/>
        <property type="gene ID" value="ENSMICG00000003957.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161592"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004935">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000944">
        <property type="entry name" value="zinc finger protein 232 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002278">
        <property type="entry name" value="Zinc finger protein 320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000307">
        <property type="entry name" value="Zinc finger protein ZFP69 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000330">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000496">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF366">
        <property type="entry name" value="ZINC FINGER PROTEIN ZFP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="20">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="KRAB" evidence="21">
        <location>
            <begin position="227"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="405"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="461"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="19">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="248"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="297"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003601.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="563" mass="63888" checksum="0F0EEB198323639E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNM4</accession>
    <name>A0A8C5UNM4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CCR4-NOT transcription complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CCR4-associated factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CNOT3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex interacts directly with CNOT2. Interacts with TIP120B and NANOS2. Interacts with EBF1. Interacts in an RNA-independent manner with BICC1 (via KH domains).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
            <location evidence="15">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
        <text evidence="15">NANOS2 promotes its localization to P-body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626271.1">
        <property type="nucleotide sequence ID" value="XM_012770817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNM4"/>
    <dbReference type="Ensembl" id="ENSMICT00000002378.3">
        <property type="protein sequence ID" value="ENSMICP00000002173.3"/>
        <property type="gene ID" value="ENSMICG00000002370.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874706"/>
    <dbReference type="CTD" id="4849"/>
    <dbReference type="GeneTree" id="ENSGT00390000014743"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000036">
        <property type="term" value="P:regulation of stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000002">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012270">
        <property type="entry name" value="CCR4-NOT_su3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007207">
        <property type="entry name" value="Not_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04065">
        <property type="entry name" value="Not3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005290">
        <property type="entry name" value="NOT_su_3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 15" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 15" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 15" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="CCR4-Not complex component Not N-terminal" evidence="17">
        <location>
            <begin position="4"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="18">
        <location>
            <begin position="623"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="240"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="16">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002173.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="753" mass="81915" checksum="63AE7F48A8F90143" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UR67</accession>
    <name>A0A8C5UR67_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Keratin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KRT3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UR67"/>
    <dbReference type="Ensembl" id="ENSMICT00000002233.3">
        <property type="protein sequence ID" value="ENSMICP00000002043.3"/>
        <property type="gene ID" value="ENSMICG00000002232.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162629"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Single helix bin"/>
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        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
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        <property type="entry name" value="IF_rod_dom"/>
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    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
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    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF38">
        <property type="entry name" value="KERATIN, TYPE II CYTOSKELETAL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="8">
        <location>
            <begin position="201"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="606"/>
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        <location>
            <begin position="205"/>
            <end position="239"/>
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    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="272"/>
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        <location>
            <begin position="414"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002043.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="631" mass="64536" checksum="DAB6055E26C32ADF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UT09</accession>
    <name>A0A8C5UT09_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Farnesyl pyrophosphate synthase</fullName>
            <ecNumber evidence="7">2.5.1.1</ecNumber>
            <ecNumber evidence="6">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">(2E,6E)-farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">FDPS</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="30">Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19361"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22408"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:58057"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="31">Homodimer. Interacts with RSAD2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 32">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="7"/>
    <dbReference type="EC" id="2.5.1.10" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03003212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UT09"/>
    <dbReference type="Ensembl" id="ENSMICT00000007465.3">
        <property type="protein sequence ID" value="ENSMICP00000006793.3"/>
        <property type="gene ID" value="ENSMICG00000007468.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000141074"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006695">
        <property type="term" value="P:cholesterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0007">Acetylation</keyword>
    <keyword evidence="13" id="KW-0152">Cholesterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="22" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="21" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="33" id="KW-0732">Signal</keyword>
    <keyword evidence="15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="17" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="11 32" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="33">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034041823" description="Farnesyl pyrophosphate synthase" evidence="33">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00034546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00053104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00062846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006793.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="394" mass="45295" checksum="90C92108184635C9" modified="2022-01-19" version="1">MPLSRWLRSVGVFLLPAPCWAPQERWLGSLRRPSLVHGRPVLGAWHGARCWCQAWTEEPRALHSSLRMNGDQKLDVYAQEKQDFIQHFSQIVRVLTEDEMGHPETGDAISRLKEVLEYNAIGGKYNRGMTVLVAFRELVEPKKQDADSLQRALTVGWCVELKPGIGLDAVNDALLLEACIYRLLKHYCREQPYYLNLIELFLQSSYQTEIGQTLDLITAPQGNVELGRFTEKRYKSIVKYKTAFYSFYLPVAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLQRATPEQRQILQENYGQKEAEKVARVKALYEELDLQAVFLQYEEDSYSHLMSLIEQYAAPLPRAIFLELARKIYKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UU81</accession>
    <name>A0A8C5UU81_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Basal body-orientation factor 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Coiled-coil domain-containing protein 176</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">BBOF1</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BBOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UU81"/>
    <dbReference type="Ensembl" id="ENSMICT00000008460.3">
        <property type="protein sequence ID" value="ENSMICP00000007703.3"/>
        <property type="gene ID" value="ENSMICG00000008464.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154427"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032777">
        <property type="entry name" value="DUF4515"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845:SF5">
        <property type="entry name" value="BASAL BODY-ORIENTATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14845">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING 166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14988">
        <property type="entry name" value="DUF4515"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4515" evidence="11">
        <location>
            <begin position="77"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4515" evidence="11">
        <location>
            <begin position="207"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="85"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="271"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007703.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="515" mass="60139" checksum="456B1D591A2BAD01" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UV38</accession>
    <name>A0A8C5UV38_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">long-chain-fatty-acid--CoA ligase</fullName>
            <ecNumber evidence="7">6.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Long-chain-fatty-acid--CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SLC27A1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15422"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:54537"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33639"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:31014"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:65052"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33640"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.3" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03027691">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UV38"/>
    <dbReference type="Ensembl" id="ENSMICT00000003392.3">
        <property type="protein sequence ID" value="ENSMICP00000003085.3"/>
        <property type="gene ID" value="ENSMICG00000003391.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159323"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009925">
        <property type="term" value="C:basal plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090434">
        <property type="term" value="F:oleoyl-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033211">
        <property type="term" value="P:adiponectin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044381">
        <property type="term" value="P:glucose import in response to insulin stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990379">
        <property type="term" value="P:lipid transport across blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015911">
        <property type="term" value="P:long-chain fatty acid import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001579">
        <property type="term" value="P:medium-chain fatty acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031652">
        <property type="term" value="P:positive regulation of heat generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010867">
        <property type="term" value="P:positive regulation of triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009409">
        <property type="term" value="P:response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000002">
        <property type="entry name" value="Long-chain fatty acid transport protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022272">
        <property type="entry name" value="Lipocalin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF7">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00213">
        <property type="entry name" value="LIPOCALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034144458" description="long-chain-fatty-acid--CoA ligase" evidence="11">
        <location>
            <begin position="32"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="12">
        <location>
            <begin position="82"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="13">
        <location>
            <begin position="509"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00036527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003085.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="632" mass="68752" checksum="62F9CA2418FF4987" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXJ2</accession>
    <name>A0A8C5UXJ2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CTP synthase</fullName>
            <ecNumber evidence="10">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">CTPS2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="16">Liver</tissue>
        </source>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03035947">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640194.1">
        <property type="nucleotide sequence ID" value="XM_012784740.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640195.1">
        <property type="nucleotide sequence ID" value="XM_012784741.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXJ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000010843.3">
        <property type="protein sequence ID" value="ENSMICP00000009879.3"/>
        <property type="gene ID" value="ENSMICG00000010839.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067599.1">
        <property type="protein sequence ID" value="ENSMICP00000047221.1"/>
        <property type="gene ID" value="ENSMICG00000010839.3"/>
    </dbReference>
    <dbReference type="CTD" id="56474"/>
    <dbReference type="GeneTree" id="ENSGT00910000144179"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097268">
        <property type="term" value="C:cytoophidium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000207">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000005">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF2">
        <property type="entry name" value="CTP SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="13">
        <location>
            <begin position="2"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="310"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009879.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="RefSeq" id="XP_012640194.1"/>
        </source>
    </evidence>
    <sequence length="586" mass="65591" checksum="0D7F084054582359" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UY90</accession>
    <name>A0A8C5UY90_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ADAM metallopeptidase with thrombospondin type 1 motif 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADAMTS13</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015003">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UY90"/>
    <dbReference type="Ensembl" id="ENSMICT00000011817.3">
        <property type="protein sequence ID" value="ENSMICP00000010760.3"/>
        <property type="gene ID" value="ENSMICG00000011799.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158379"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000005">
        <property type="entry name" value="ADAM metallopeptidase with thrombospondin type 1 motif 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035914">
        <property type="entry name" value="Sperma_CUB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF318">
        <property type="entry name" value="PEPTIDASE M12B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19030">
        <property type="entry name" value="TSP1_ADAMTS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49854">
        <property type="entry name" value="Spermadhesin, CUB domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010760.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="515" mass="55076" checksum="9129B962A59BF20E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V147</accession>
    <name>A0A8C5V147_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450 family 26 subfamily C member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14 16" type="primary">CYP26C1</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51984"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:51985"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621498.1">
        <property type="nucleotide sequence ID" value="XM_012766044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V147"/>
    <dbReference type="Ensembl" id="ENSMICT00000013125.3">
        <property type="protein sequence ID" value="ENSMICP00000011966.2"/>
        <property type="gene ID" value="ENSMICG00000013120.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872179"/>
    <dbReference type="KEGG" id="mmur:105872179"/>
    <dbReference type="CTD" id="340665"/>
    <dbReference type="VGNC" id="VGNC:80507">
        <property type="gene designation" value="CYP26C1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00800000124060"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008401">
        <property type="term" value="F:retinoic acid 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001972">
        <property type="term" value="F:retinoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014032">
        <property type="term" value="P:neural crest cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034653">
        <property type="term" value="P:retinoic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000009">
        <property type="entry name" value="Cytochrome P450 26B1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF100">
        <property type="entry name" value="CYTOCHROME P450 26C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="7 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011966.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="VGNC" id="VGNC:80507"/>
        </source>
    </evidence>
    <sequence length="523" mass="57346" checksum="455781C3B7757E73" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1H8</accession>
    <name>A0A8C5V1H8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SHC SH2 domain-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SHCBP1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts directly with isoform p52shc of SHC1 via its SH2 domain. Interacts with TRIM71; leading to enhanced SHCBP1 protein stability. Interacts with both members of the centralspindlin complex, KIF23 and RACGAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Midbody</location>
        </subcellularLocation>
    </comment>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1H8"/>
    <dbReference type="Ensembl" id="ENSMICT00000013796.3">
        <property type="protein sequence ID" value="ENSMICP00000012585.3"/>
        <property type="gene ID" value="ENSMICG00000013801.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161310"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008543">
        <property type="term" value="P:fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000020">
        <property type="entry name" value="SHC SH2 domain-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057508">
        <property type="entry name" value="SHCBP-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045140">
        <property type="entry name" value="SHCBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695:SF8">
        <property type="entry name" value="SHC SH2 DOMAIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14695">
        <property type="entry name" value="SHC SH2-DOMAIN BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23762">
        <property type="entry name" value="SHCBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SHC SH2" evidence="12">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Right handed beta helix" evidence="11">
        <location>
            <begin position="244"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012585.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="473" mass="53427" checksum="FEA8DEF1285F498F" modified="2022-01-19" version="1">FFYQNIWRSWDEEEEDEYDYFVRCVEPRLRLHYDILEDRVPSGLIVDYRNLLSQCEESYRKFLNLRSSLSNCNSDSEQENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGIRPSGQKVTHVVSSTMTTGLLRALLSDRLCQDPYEEETEIQFHRDPLSAINACYEGDTVIVCPGHYVVHGTFSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGADIKISCIKFVQHDAVEGILIIHRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSKCVLTDNGIHHCKEGILIKDFLDEHYDIPKISMVNNIVHNNEGYGVVLVKPTIFSDLQENAQDGTEESKAFKIQTSEEADATERVDLEELIQCAAGKMELYPRSDLSEQVEGNCEIINELVAASTQKGQMKKKRLSELGITQADDNLMSQEMFVGIVGNQFKWNGKGSFGTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5K8</accession>
    <name>A0A8C5V5K8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="2">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">BST1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADP-ribosyl cyclase family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03005453">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593009.1">
        <property type="nucleotide sequence ID" value="XM_012737555.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5K8"/>
    <dbReference type="Ensembl" id="ENSMICT00000016940.3">
        <property type="protein sequence ID" value="ENSMICP00000015438.3"/>
        <property type="gene ID" value="ENSMICG00000016939.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856080"/>
    <dbReference type="KEGG" id="mmur:105856080"/>
    <dbReference type="CTD" id="683"/>
    <dbReference type="GeneTree" id="ENSGT00390000017291"/>
    <dbReference type="OrthoDB" id="9944984at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001931">
        <property type="term" value="C:uropod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016849">
        <property type="term" value="F:phosphorus-oxygen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030890">
        <property type="term" value="P:positive regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032956">
        <property type="term" value="P:regulation of actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050848">
        <property type="term" value="P:regulation of calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001952">
        <property type="term" value="P:regulation of cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090022">
        <property type="term" value="P:regulation of neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04759">
        <property type="entry name" value="Rib_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.82.10">
        <property type="entry name" value="ADP Ribosyl Cyclase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003193">
        <property type="entry name" value="ADP-ribosyl_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10912:SF4">
        <property type="entry name" value="ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02267">
        <property type="entry name" value="Rib_hydrolayse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52309">
        <property type="entry name" value="N-(deoxy)ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044149983" description="ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015438.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="322" mass="36252" checksum="3CF2D6AD6840FE4D" modified="2022-01-19" version="1">MAVPERVPSRRQLPRRLLLLLLPLAAGVGRAGGARWSGEGTSPHLQSIFLGRCAEYSALLRPELRDKNCTAIWEAFKVVLDKDPCSVLPSDYDLFINLSRHSIPRDKSLFWENNHLLVTSYAENTRRFMPVCDVLYGRVGDFLSWCRQKNASGLDYQSCPTSEDCENNPVDSFWKRASMQYSTDSSGVIYVMLNGSEPEGAYPINGFFADYEVPYFQKDKITRIEIWVMHDIGRPNVESCGEGSVKILEARLKEMGFQYSCVDDYRPVKLLQCVDHSTHPDCALNSAAVSTHREAPSYYAKQSVSHIIPLLLALASGTQMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V667</accession>
    <name>A0A8C5V667_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARF like GTPase 13A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ARL13A</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034162">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03034163">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V667"/>
    <dbReference type="Ensembl" id="ENSMICT00000014151.3">
        <property type="protein sequence ID" value="ENSMICP00000012902.2"/>
        <property type="gene ID" value="ENSMICG00000014153.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161284"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097730">
        <property type="term" value="C:non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905515">
        <property type="term" value="P:non-motile cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097500">
        <property type="term" value="P:receptor localization to non-motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04161">
        <property type="entry name" value="Arl2l1_Arl13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000415">
        <property type="entry name" value="ADP-ribosylation factor-like GTPase 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051995">
        <property type="entry name" value="Ciliary_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46090">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="218" mass="25132" checksum="93C465FA7555555D" modified="2022-01-19" version="1">MIRLLTSCWSRLRTTEEARRNVTILFIGLDNSGKTVLVEAFQRLLPSRIDNCVQSGLTTLLLDEYEVSIYDLNGDRKGRETWPNYYARAHGLVFVLDSSDIERMQEVKIILTRLLSDKRVAGKPILLLANKQDKKNALLPCDIIEYLLLKRLVNEYDSLCRVEPCSAIRNLPRRNHQPIIKGLRWLLALCTRQPPPISNIPASRHSRRCGERCSSDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6L9</accession>
    <name>A0A8C5V6L9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Gamma-aminobutyric acid type A receptor subunit alpha4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">GABRA4</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029332">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598507.1">
        <property type="nucleotide sequence ID" value="XM_012743053.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6L9"/>
    <dbReference type="Ensembl" id="ENSMICT00000017780.3">
        <property type="protein sequence ID" value="ENSMICP00000016190.2"/>
        <property type="gene ID" value="ENSMICG00000017780.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859338"/>
    <dbReference type="KEGG" id="mmur:105859338"/>
    <dbReference type="CTD" id="2557"/>
    <dbReference type="GeneTree" id="ENSGT00940000159024"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
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        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004890">
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    </dbReference>
    <dbReference type="GO" id="GO:0007417">
        <property type="term" value="P:central nervous system development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19037">
        <property type="entry name" value="LGIC_ECD_GABAAR_A4"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19052">
        <property type="entry name" value="LGIC_TM_GABAAR_alpha"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
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    <dbReference type="FunFam" id="1.20.58.390:FF:000002">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GABAA/Glycine_rcpt"/>
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    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
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        <property type="entry name" value="GABBAa4_rcpt"/>
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    <dbReference type="InterPro" id="IPR047024">
        <property type="entry name" value="Gabra-1-6_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
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    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
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    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
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        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
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    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
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        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
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        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
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        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GABAARALPHA"/>
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        <property type="entry name" value="GABAARALPHA4"/>
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        <property type="entry name" value="GABAARECEPTR"/>
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        <property type="entry name" value="NRIONCHANNEL"/>
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        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 19" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039453" evidence="19">
        <location>
            <begin position="28"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="49"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="263"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="353"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="491"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="503"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000687"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016190.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="556" mass="61452" checksum="804E526B34A45964" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9U2</accession>
    <name>A0A8C5V9U2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SGK1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03008432">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008433">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008434">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008435">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008437">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008438">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594935.1">
        <property type="nucleotide sequence ID" value="XM_012739481.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9U2"/>
    <dbReference type="Ensembl" id="ENSMICT00000045989.2">
        <property type="protein sequence ID" value="ENSMICP00000018610.1"/>
        <property type="gene ID" value="ENSMICG00000007886.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155726"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017080">
        <property type="term" value="F:sodium channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05602">
        <property type="entry name" value="STKc_SGK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000065">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000030">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="193"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="451"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="161"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="526" mass="59923" checksum="E3C3048304EB6803" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAN5</accession>
    <name>A0A8C5VAN5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">cAMP-regulated phosphoprotein 19</fullName>
        </recommendedName>
    </protein>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts (when phosphorylated at Ser-62) with PPP2R2D. Interacts with SNCA. Interacts with PPP2R2A; the interaction is direct and this interaction inhibits PP2A activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006191">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VAN5"/>
    <dbReference type="Ensembl" id="ENSMICT00000046783.2">
        <property type="protein sequence ID" value="ENSMICP00000019166.2"/>
        <property type="gene ID" value="ENSMICG00000034539.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154555"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF4">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 11" id="KW-0650">Protein phosphatase inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019166.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="98" mass="10917" checksum="FC29B69E8FF0F7DB" modified="2022-01-19" version="1">MSAEVPEAASAEEQKEMEDKLKRQNLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPAAAPDKTEVTDLPQRKPSLVASKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAR8</accession>
    <name>A0A8C5VAR8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ArfGAP with dual PH domains 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADAP1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021029">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614568.1">
        <property type="nucleotide sequence ID" value="XM_012759114.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VAR8"/>
    <dbReference type="Ensembl" id="ENSMICT00000015736.3">
        <property type="protein sequence ID" value="ENSMICP00000014336.2"/>
        <property type="gene ID" value="ENSMICG00000015739.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868358"/>
    <dbReference type="CTD" id="11033"/>
    <dbReference type="GeneTree" id="ENSGT00940000155698"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043533">
        <property type="term" value="F:inositol 1,3,4,5 tetrakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005547">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08843">
        <property type="entry name" value="ArfGap_ADAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13252">
        <property type="entry name" value="PH1_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01251">
        <property type="entry name" value="PH2_ADAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000011">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000080">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000099">
        <property type="entry name" value="Arf-GAP with dual PH domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052589">
        <property type="entry name" value="Arf-GAP_dual-PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037849">
        <property type="entry name" value="PH1_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037851">
        <property type="entry name" value="PH2_ADAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021:SF5">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46021">
        <property type="entry name" value="ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="10">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="129"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="252"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014336.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="374" mass="43294" checksum="B9A9712446C24D2D" modified="2022-01-19" version="1">MAGERRGAILELLRRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARATFESKVPSFYYRPTFSDCQVLREQWIRAKYERREFVHPDKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRSDAKEPKAIMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYKVLDGLPPSTQGYHWPHGITIVTPDRKFLFTCETESDQREWVAAFQKVVDRPMLPQEYAVEAHFKHKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VB39</accession>
    <name>A0A8C5VB39_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004881">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VB39"/>
    <dbReference type="Ensembl" id="ENSMICT00000028747.2">
        <property type="protein sequence ID" value="ENSMICP00000019419.2"/>
        <property type="gene ID" value="ENSMICG00000030696.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183123"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000048">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein a1 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026">
        <property type="entry name" value="HOMOLOGOUS TO DROSOPHILA SQD (SQUID) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48026:SF26">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="95"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019419.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="274" mass="29792" checksum="5C868D45E526CEC1" modified="2022-01-19" version="1">ISKSKSPEERWSFETTDESLRSHFEQWGTLTDSVVMRDPNTERSKGFGFVIYATVEEVDAAMNARPHKVDGRVVEPKRAVSGEDSQRPGAHLTVKKIFVAGIKEDTKERHLRDYFEQYGKTEKRGFPFVTFDDHDSVNKTHTVISHNCEVRKALSKQEMASVSSSQREQSGSGNFDGGCGGNFSGHCSFGGSHGGGGHGGSRDGYNGFGNDGSNFGGGRSYDDFGNFGGRNSGPYGDGGQYFAKPRNQGGYCGSSSNSSYSSGRKFLLLSRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCR6</accession>
    <name>A0A8C5VCR6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Decaprenyl diphosphate synthase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PDSS2</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608599.1">
        <property type="nucleotide sequence ID" value="XM_012753145.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VCR6"/>
    <dbReference type="Ensembl" id="ENSMICT00000049317.2">
        <property type="protein sequence ID" value="ENSMICP00000017766.1"/>
        <property type="gene ID" value="ENSMICG00000032777.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105864940"/>
    <dbReference type="KEGG" id="mmur:105864940"/>
    <dbReference type="CTD" id="57107"/>
    <dbReference type="GeneTree" id="ENSGT00940000153498"/>
    <dbReference type="OrthoDB" id="9983019at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032478">
        <property type="term" value="C:heterotetrameric polyprenyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110142">
        <property type="term" value="C:ubiquinone biosynthesis complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097269">
        <property type="term" value="F:all-trans-decaprenyl-diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052923">
        <property type="term" value="F:all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021549">
        <property type="term" value="P:cerebellum development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050878">
        <property type="term" value="P:regulation of body fluid levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000016">
        <property type="entry name" value="decaprenyl-diphosphate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF55">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="399" mass="44159" checksum="246E277E49DF3D31" modified="2022-01-19" version="1">MNLQQLLRLPRYLGALGPPRRRWWSPSLDTIASVGSWRGQSSRSPAYWNQVVSEAEKIVGYPTSFMSLRCLLSDELSNIAMQVRKLVGTQHPLLTTARELVHDSRHNLQLRGLVVLLISKAAGPSSMNASCQNYDMVSGIYSCQRSLAEITELIHTALLVHRGIVNLNELQSSDGPLKDMQFGNKIAILSGDFLLANACNGLALLQNTKVVELLASALMDLVQGAYHENSTSAKETYITDDIGISTWKEKTFLSHGALLAKSCQAAMELAKHDAEVQDMAFQYGKHMAMSHKINSDLQPFIKEKTSDSMTFNLNSAPVVLHQEFLGRDLWIKQIREAQEKGILDYAKLRETIKAGKGVTSAIDLCRYHGNKALAALESFPPSEARSALENIVFAVTRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VK26</accession>
    <name>A0A8C5VK26_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ribosomal protein S6 kinase</fullName>
            <ecNumber evidence="16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">RPS6KA4</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="16"/>
    <dbReference type="EMBL" id="ABDC03005869">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633403.1">
        <property type="nucleotide sequence ID" value="XM_012777949.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VK26"/>
    <dbReference type="Ensembl" id="ENSMICT00000028399.2">
        <property type="protein sequence ID" value="ENSMICP00000024777.1"/>
        <property type="gene ID" value="ENSMICG00000029334.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878482"/>
    <dbReference type="KEGG" id="mmur:105878482"/>
    <dbReference type="CTD" id="8986"/>
    <dbReference type="GeneTree" id="ENSGT00940000161083"/>
    <dbReference type="OrthoDB" id="6764942at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035175">
        <property type="term" value="F:histone H3S10 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044022">
        <property type="term" value="F:histone H3S28 kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070498">
        <property type="term" value="P:interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001818">
        <property type="term" value="P:negative regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000109">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000157">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000208">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000686">
        <property type="entry name" value="Ribosomal protein S6 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016239">
        <property type="entry name" value="Ribosomal_S6_kinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000606">
        <property type="entry name" value="Ribsml_S6_kin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="9 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="33"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
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        <location>
            <begin position="411"/>
            <end position="674"/>
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    </feature>
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        <location>
            <begin position="673"/>
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        <location>
            <begin position="728"/>
            <end position="764"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="39"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 19">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="417"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18 19">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009804"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="764" mass="84981" checksum="6AE28F54955A48B3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VKM2</accession>
    <name>A0A8C5VKM2_MICMU</name>
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        <name evidence="11" type="primary">LOC105881832</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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            <end position="68"/>
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            <begin position="122"/>
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    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="406" mass="45189" checksum="2704A864352688DF" modified="2022-01-19" version="1">MVKETEYYDILGVKPSASREEIKKAYRKLALKYHPDKKPGEGEKFKLTSQAYEVLSDPKKRDVYDQGGEQAIKEGDSGGPSFSSPMDIFDMFFGGGGRTARERRGKNVVHQLSVTLEDLYNGASKKLALQKNVICEKCEGIGGKKGSMEKCPLCKGQGMLTRTQQTGPGAVRQVQTVCVECRGQGERVNPKGRCGCCRGAKVPRERKISQLFSKCMKDGQKMLFHGEGGQEPGLGPGDVIIVLDQKDRSVFQRRGHDLIMKMKIHLSEALCGFKKTVKTPDDRILVITSKSGEVIKHGDLKCVRNEGMPICEAPLEKGTLIIQFLVIFPETHWLSPEKLPQLEALLPPRQKVRITDDMDHVELKDFNPSEQSWRQHGEAYQEDDDGPGPECSARRRDMAVSAALPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM50</accession>
    <name>A0A8C5VM50_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Centromere protein N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CENPN</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-N/CHL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602019.1">
        <property type="nucleotide sequence ID" value="XM_012746565.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602020.1">
        <property type="nucleotide sequence ID" value="XM_012746566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM50"/>
    <dbReference type="Ensembl" id="ENSMICT00000054752.2">
        <property type="protein sequence ID" value="ENSMICP00000021255.1"/>
        <property type="gene ID" value="ENSMICG00000011918.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861204"/>
    <dbReference type="KEGG" id="mmur:105861204"/>
    <dbReference type="CTD" id="55839"/>
    <dbReference type="GeneTree" id="ENSGT00390000004738"/>
    <dbReference type="OrthoDB" id="6585699at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052011">
        <property type="entry name" value="CENP-NAC/CAD_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007902">
        <property type="entry name" value="Chl4/mis15/CENP-N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46790:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05238">
        <property type="entry name" value="CENP-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="336" mass="39093" checksum="ED2CD8DEE909EDF0" modified="2022-01-19" version="1">MDETVAEFIKRTILKIPMSQMTTILKAWEFLSENQLQTVNFRQRKESVVQHLVELCEEKHASLNDAALLDIIYTQVHRHQKMWDVFQMSKGPGEDVDPFDMKQFKSSFKKVLQRALKNVTVSFRDTEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSLSTLKSNIPLLGQALKIASKHQEIVKMDLRSRYLDSLKAIVFKQYNQNFETHNPTTPLQERSVGLHVNMDSRIIHENAMEKERVQRITQETFGDYPQPQIEFAQYKLETKFKNGSILAEREEPLRCLIKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPNKKMNYFKIRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQG1</accession>
    <name>A0A8C5VQG1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylaspartylglutamate synthase</fullName>
            <ecNumber evidence="2">6.3.2.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">RIMKLB</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-L-aspartate + L-glutamate + ATP = N-acetyl-L-aspartyl-L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40035"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16953"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:76931"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.41"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimK family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.41" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03010386">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQG1"/>
    <dbReference type="Ensembl" id="ENSMICT00000040201.2">
        <property type="protein sequence ID" value="ENSMICP00000027921.2"/>
        <property type="gene ID" value="ENSMICG00000032577.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000014577"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072590">
        <property type="term" value="F:N-acetyl-L-aspartate-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000022">
        <property type="entry name" value="beta-citrylglutamate synthase B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000014">
        <property type="entry name" value="beta-citrylglutamate synthase B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="Rp_bS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621:SF5">
        <property type="entry name" value="BETA-CITRYLGLUTAMATE SYNTHASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21621">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 MODIFICATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="119"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027921.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="382" mass="41967" checksum="0B07249570C8C676" modified="2022-01-19" version="1">MCSSVAAKLWFLTDRRIREDYPQKEILRALKAKCCEEELDFRAVVMDEVVLTIEQGNLGLRINGELITAYPQVVVVRVPTPWVQSDSDITVLRHLEKMGCRLMNRPQAILNCVNKFWTFQELAGHGVPLPDTFSYGFMGLKFSMVILVILPTILLFFSITGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIKLLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VSP8</accession>
    <name>A0A8C5VSP8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dmx like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DMXL2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004506">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000027006.2"/>
        <property type="gene ID" value="ENSMICG00000010807.3"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="FunFam" id="2.130.10.10:FF:000150">
        <property type="entry name" value="Dmx-like 2, isoform CRA_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000254">
        <property type="entry name" value="dmX-like protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="DmX-like/RAVE_component"/>
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    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
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    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="DMX-LIKE PROTEIN 2"/>
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        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
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    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
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    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="7">
        <location>
            <begin position="1142"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="7">
        <location>
            <begin position="1491"/>
            <end position="1901"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="2898"/>
            <end position="2939"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="2940"/>
            <end position="2981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1986"/>
            <end position="2019"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2124"/>
            <end position="2151"/>
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    </feature>
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        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="947"/>
            <end position="956"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2001"/>
            <end position="2014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027006.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="3038" mass="340263" checksum="E12D92465613CD2D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VU06</accession>
    <name>A0A8C5VU06_MICMU</name>
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        <recommendedName>
            <fullName evidence="10">Ubiquitin D</fullName>
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        <alternativeName>
            <fullName evidence="12">Diubiquitin</fullName>
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        <alternativeName>
            <fullName evidence="11">Ubiquitin-like protein FAT10</fullName>
        </alternativeName>
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    <gene>
        <name evidence="14" type="primary">UBD</name>
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    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts directly with the 26S proteasome. Interacts with NUB1; this interaction facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation and that of its conjugates. Interacts (via ubiquitin-like 1 domain) with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg). Interacts with SQSTM1 and TP53/p53.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin D family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012760359.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5VU06"/>
    <dbReference type="Ensembl" id="ENSMICT00000051085.2">
        <property type="protein sequence ID" value="ENSMICP00000026322.1"/>
        <property type="gene ID" value="ENSMICG00000035072.2"/>
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    <dbReference type="GeneID" id="105868938"/>
    <dbReference type="KEGG" id="mmur:105868938"/>
    <dbReference type="CTD" id="10537"/>
    <dbReference type="GeneTree" id="ENSGT00910000144359"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016235">
        <property type="term" value="C:aggresome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070842">
        <property type="term" value="P:aggresome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043011">
        <property type="term" value="P:myeloid dendritic cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901990">
        <property type="term" value="P:regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17052">
        <property type="entry name" value="Ubl1_FAT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000234">
        <property type="entry name" value="Ubiquitin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000249">
        <property type="entry name" value="Ubiquitin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
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    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
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        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="InterPro" id="IPR042969">
        <property type="entry name" value="Ubiquitin_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
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    <dbReference type="PANTHER" id="PTHR47731">
        <property type="entry name" value="UBIQUITIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47731:SF1">
        <property type="entry name" value="UBIQUITIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="13">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="165" mass="18798" checksum="F8F54B191F771B89" modified="2022-01-19" version="1">MAPNASCLCVTIYSMEWELMTFDANLDDRVKKINEHVRSNTKVPVQDQVLLLGSKILKPQRRLSSYGIEKEKTIHLTLKVAKPRDEELPLFLVESADEGQRHLLRVQRYSSVAQVKEMIETKTAITPETQIVTCKGKRLEDGKIMADYNIRKGNILFLTEHCIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZI0</accession>
    <name>A0A8C5VZI0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">POMT1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03014954">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599531.1">
        <property type="nucleotide sequence ID" value="XM_012744077.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VZI0"/>
    <dbReference type="Ensembl" id="ENSMICT00000051205.2">
        <property type="protein sequence ID" value="ENSMICP00000032186.1"/>
        <property type="gene ID" value="ENSMICG00000004891.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859860"/>
    <dbReference type="KEGG" id="mmur:105859860"/>
    <dbReference type="CTD" id="10585"/>
    <dbReference type="GeneTree" id="ENSGT00940000158049"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23281">
        <property type="entry name" value="beta-trefoil_MIR_POMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="571"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="296"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="370"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="431"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="725" mass="82526" checksum="1456B68B775BAB61" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1T4</accession>
    <name>A0A8C5W1T4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03021658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1T4"/>
    <dbReference type="Ensembl" id="ENSMICT00000035372.2">
        <property type="protein sequence ID" value="ENSMICP00000035063.2"/>
        <property type="gene ID" value="ENSMICG00000035984.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074618"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035063.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="198" mass="22152" checksum="7DD51B5E48D10A62" modified="2022-01-19" version="1">LFFLFYRARYCERVTILPGNRGSRQITYVYGFYENIGNENVWKYCTDLFGYLPLTALVDRQRFCLHGGPAPCTDTPDHIRALGRLQAVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETLNQANGLTLVSGAHQLCHDRNAFSAPNYCYRCGHQAAITGLDETLKYSFLQFDPAPDRGEPGVTGHTPDHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W4Q8</accession>
    <name>A0A8C5W4Q8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">THG1L</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer. Interacts with MFN1 and MFN2; functions as a guanyl-nucleotide exchange factor/GEF for MFN2 and also probably MFN1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03027443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637020.1">
        <property type="nucleotide sequence ID" value="XM_012781566.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W4Q8"/>
    <dbReference type="Ensembl" id="ENSMICT00000054857.2">
        <property type="protein sequence ID" value="ENSMICP00000035055.1"/>
        <property type="gene ID" value="ENSMICG00000038734.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880495"/>
    <dbReference type="KEGG" id="mmur:105880495"/>
    <dbReference type="CTD" id="54974"/>
    <dbReference type="GeneTree" id="ENSGT00390000011705"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990046">
        <property type="term" value="P:stress-induced mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 12" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="15">
        <location>
            <begin position="67"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="16">
        <location>
            <begin position="199"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="90"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="136"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="330" mass="38444" checksum="5832FD1778ABBAC7" modified="2022-01-19" version="1">MQTSVRLERPRWKEKLPGRGSPSLPFRGVGGGMWAACNIKVRDCLVAASVVLRRCLRVEATMAKSKFEYVREFEADDTCLPHCWVVVRLDGRNFHRFADKHSFAKPNDSRALHLMTKCAQTVMEELEDIVIAYGQSDEYSFVFKRKSNWFKRRASKFMTHVASQFASSYVFYWRDYFKDQPLLYPPGFDGRVVVYPSNQTLRDYLSWRQADCHINNLYNTVFWTLIQQSGLTPVQAQERLQGTLAAEKNEILFSEFNINYNNEPPMYRKGTVLIWQKVDEVMTKEVKLPAEMEGKKMAVTRTRTKPVPLHCDIIGDAFWKEHLEILDEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W4S6</accession>
    <name>A0A8C5W4S6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Solute carrier family 30 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC30A1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Zn(2+)(in) + 2 H(+)(out) = Zn(2+)(out) + 2 H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:72627"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029981">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637134.1">
        <property type="nucleotide sequence ID" value="XM_012781680.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W4S6"/>
    <dbReference type="Ensembl" id="ENSMICT00000046979.2">
        <property type="protein sequence ID" value="ENSMICP00000036544.1"/>
        <property type="gene ID" value="ENSMICG00000034511.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880549"/>
    <dbReference type="KEGG" id="mmur:105880549"/>
    <dbReference type="CTD" id="7779"/>
    <dbReference type="GeneTree" id="ENSGT00940000156484"/>
    <dbReference type="OMA" id="CLFHQHG"/>
    <dbReference type="OrthoDB" id="29444at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010312">
        <property type="term" value="P:detoxification of zinc ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090281">
        <property type="term" value="P:negative regulation of calcium ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071584">
        <property type="term" value="P:negative regulation of zinc ion transmembrane import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062111">
        <property type="term" value="P:zinc ion import into organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF1">
        <property type="entry name" value="PROTON-COUPLED ZINC ANTIPORTER SLC30A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="13">
        <location>
            <begin position="13"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="14">
        <location>
            <begin position="349"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="508" mass="55367" checksum="DA67FBE9EC3DF932" modified="2022-01-19" version="1">MGCWGRNRGRLLCMLMLTFMFMVLEVVVSRVTSSLAMLSDSFHMLSDVLALVVALVAERFARRTHATQKNTFGWIRAEVMGALVNAIFLTGLCFAILLEAIERFIEPHEMQQPLVVLAVGVAGLLVNVLGLCLFHHHSGFSQDSGHGHSHGGHGHSHGLPKGGRLKSNRAGSSDINEAPGEPGPDPEETNTLVTSAGNSNGLKLDPADPEKSPNNDPVEVQVNGNLIREPDRVELEEEDRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFSWKGCSEGDFCVNPCTPDPCKAFVEVINSTHAPVYEAGPCWVLYLDPTLCIVMVCILLYTTYPLLKESALILLQTVPKQIDIRNLIKELRNVEGVEEVHELHVWQLAGSRIIATAHIKCEDPTSYMQVAKTIKDVFHNHGIHATTIQPEFASVGSKSGVVPCELACRTQCALKQCCGALPQALSGKDTEKTPAISISCLELSDNLEKKPKRTKVENIPAVVVDIKKMPNNQPESSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5WA57</accession>
    <name>A0A8C5WA57_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019331">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5WA57"/>
    <dbReference type="Ensembl" id="ENSMICT00000047532.2">
        <property type="protein sequence ID" value="ENSMICP00000037309.1"/>
        <property type="gene ID" value="ENSMICG00000028726.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008744"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="3">
        <location>
            <begin position="167"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="255" mass="26907" checksum="DF51E98EAFE8E8F9" modified="2022-01-19" version="1">MDSLCCGVFAGNSRELSIRSCLPSLFQAEQTHRSILLGMLLGAGQSPQLDSALIRQAQAERRSQWSLRGGLEMLPQALETHLTSRGISVLKGHPVSGALEVSLGDSSLEADHVISAIPASVLSKLLPAEAAPLAVPSAITAVSSSACPGNDVGSWLQTLEASGCVLSQELFQHQAQKAAATQLGLTEPPSYCLVHPHKNCIPQYTLGHWQKLESARQFLAAQRLPLTLAGASHEGVAVNDCIESGRQAAVSALHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XD01</accession>
    <name>A0A8C5XD01_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-CpG binding domain protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MBD2</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022249">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XD01"/>
    <dbReference type="Ensembl" id="ENSMICT00000008965.3">
        <property type="protein sequence ID" value="ENSMICP00000008165.3"/>
        <property type="gene ID" value="ENSMICG00000008970.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183005"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016581">
        <property type="term" value="C:NuRD complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070742">
        <property type="term" value="F:C2H2 zinc finger domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035197">
        <property type="term" value="F:siRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006346">
        <property type="term" value="P:DNA methylation-dependent constitutive heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042711">
        <property type="term" value="P:maternal behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030177">
        <property type="term" value="P:positive regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01396">
        <property type="entry name" value="MeCP2_MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.890.10:FF:000003">
        <property type="entry name" value="methyl-CpG-binding domain protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.890.10">
        <property type="entry name" value="Methyl-cpg-binding Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032343">
        <property type="entry name" value="MBD2/MBD3_p55-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025884">
        <property type="entry name" value="MeCpG-bd_2/3_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001739">
        <property type="entry name" value="Methyl_CpG_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396">
        <property type="entry name" value="METHYL-CPG BINDING PROTEIN, MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12396:SF5">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01429">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14048">
        <property type="entry name" value="MBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16564">
        <property type="entry name" value="MBDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00391">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50982">
        <property type="entry name" value="MBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MBD" evidence="10">
        <location>
            <begin position="132"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008165.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="398" mass="42020" checksum="3CA5E9370200F088" modified="2022-01-19" version="1">MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGPGRRRLWPWPGPWPWPGTGGPGRAAAVPSGGGGLGGDGGGCGGSSGAGGAPRREPVPFPSGSAGLGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNTVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEMDIEMDSGDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XET7</accession>
    <name>A0A8C5XET7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="6">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">GCH1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03004269">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613483.1">
        <property type="nucleotide sequence ID" value="XM_012758029.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XET7"/>
    <dbReference type="Ensembl" id="ENSMICT00000016224.3">
        <property type="protein sequence ID" value="ENSMICP00000014787.2"/>
        <property type="gene ID" value="ENSMICG00000016234.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867709"/>
    <dbReference type="KEGG" id="mmur:105867709"/>
    <dbReference type="CTD" id="2643"/>
    <dbReference type="GeneTree" id="ENSGT00390000013481"/>
    <dbReference type="OrthoDB" id="9522698at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051019">
        <property type="term" value="F:mitogen-activated protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042416">
        <property type="term" value="P:dopamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050884">
        <property type="term" value="P:neuromuscular process controlling posture"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010460">
        <property type="term" value="P:positive regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014916">
        <property type="term" value="P:regulation of lung blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000121">
        <property type="term" value="P:regulation of removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034612">
        <property type="term" value="P:response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034341">
        <property type="term" value="P:response to type II interferon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF11">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0783">Tetrahydrobiopterin biosynthesis</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="19">
        <location>
            <begin position="73"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014787.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="250" mass="27964" checksum="FD3D99DC1689D786" modified="2022-01-19" version="1">MEDGPVRAPAEQPRGARCSNGFPEREPPRPGPSRPAEKSPRPEAKSAQPAGSWKGERPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALRPAGVGVVVEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XFN3</accession>
    <name>A0A8C5XFN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleosome assembly protein 1-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007536">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XFN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000029007.2">
        <property type="protein sequence ID" value="ENSMICP00000017624.2"/>
        <property type="gene ID" value="ENSMICG00000036804.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161696"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000001">
        <property type="entry name" value="Nucleosome assembly protein 1-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="368"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017624.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="47822" checksum="ADEB41C1C31E6E75" modified="2022-01-19" version="1">MFFKLKVCSNPASSQSVSAIFPTACAHFVSLCHSLVILTISNVFIIIISVMVITDIDNKEQCELDQDLDDVEEVEEETGEETKIKACQLTVQMMRNPQILAALQEGLDGLVETPTGYTESLPRVAKRRVNVLKNLQVKCAQIEAKFYEEVHDLERKYGAPYQPLLDKRFEIINAVYEPTEEECEWKPDEDDEISEELKRRKKDEEKEDPKGIPEFWLTVLKNVDLLSEMVREHDEPILNFVLEFHFEPNEYFTNEVLTETYRMGSEPDDSDPFSFDGPEIMGCTGCQIDWEKGKNVTLKTIKKKQKHKGRGPVRTVTETVSNDSFFSLCAHPEVPKSEDLEDGAEAIPAADSETGHFLRERTIPRSVLYLTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHT3</accession>
    <name>A0A8C5XHT3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription rescue factor 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LOC105869453</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XHT3"/>
    <dbReference type="Ensembl" id="ENSMICT00000043074.2">
        <property type="protein sequence ID" value="ENSMICP00000023834.1"/>
        <property type="gene ID" value="ENSMICG00000033715.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009366"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903108">
        <property type="term" value="P:regulation of mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057896">
        <property type="entry name" value="MTRES1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13633:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION RESCUE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25818">
        <property type="entry name" value="MTRES1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial transcription rescue factor 1 C-terminal" evidence="2">
        <location>
            <begin position="105"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="212" mass="24504" checksum="A5DFA654CD6E2E2C" modified="2022-01-19" version="1">MAMTNVRLLAGILRKPDAWIGLWGVTELNASNYKTFFRNIFSLRLPGLLISPEYVFSIFPLKKSTKTSPQKVEDEEDSDAEEDDNEMSEMEEELEDDPSVVKEYKDLEKGVPSFRYDVILKTGLDVGRNKVEEAFYKGELRLNGEKLWKKSRTVKMGDTLDLLIGDSKEAEAETVMQILLKKVFEEKTQSEKYRVVLRRWKNLKLPKKSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHT6</accession>
    <name>A0A8C5XHT6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Progestin and adipoQ receptor family member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PAQR6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ADIPOR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003186">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623202.1">
        <property type="nucleotide sequence ID" value="XM_012767748.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XHT6"/>
    <dbReference type="Ensembl" id="ENSMICT00000041206.2">
        <property type="protein sequence ID" value="ENSMICP00000023929.1"/>
        <property type="gene ID" value="ENSMICG00000002252.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873136"/>
    <dbReference type="KEGG" id="mmur:105873136"/>
    <dbReference type="CTD" id="79957"/>
    <dbReference type="GeneTree" id="ENSGT00940000160567"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="ADIPOR/PROGESTIN RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855:SF39">
        <property type="entry name" value="MEMBRANE PROGESTIN RECEPTOR DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604254-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="344" mass="38308" checksum="78460CDC2245333D" modified="2022-01-19" version="1">MLSLKLPQLLRVHQVPRVFWEDGIMSGYRRPTSSALDCVLSSFQMTNETVNIWTHFLPTWYFLWRLLVLAGGPGFRAEPYHWPLLIFLLPACLYPFASCCAHTFSSMSPRARHICYFLDYGALSLYSLGCAFPYAAYSMPASWLHGRLHQLFVPAAALNSFLCTGLSCYSRFHELESPGLSKVLRTAAFAYPFLFDNLPLFYRLGLCWGRGHSCGQEMLSTSHGYHLFCALLTGFLFASHLPERLAPGRFDYIGHSHQLFHICAVLGTHFQLEAVLADMGSRRAWLATQEPALDLVGTVATLSLAVAGNLLIIAAFTFSLLQAPGTCPLLQDGQLEGGTQAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJ15</accession>
    <name>A0A8C5XJ15_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GRWD1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with METTL18. Interacts with CDT1; origin binding of GRWD1 is dependent on CDT1. Interacts with CDC6; origin binding of GRWD1 is dependent on CDC6. Binds to histone H2A-H2B and H3-H4 complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026833">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609815.1">
        <property type="nucleotide sequence ID" value="XM_012754361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJ15"/>
    <dbReference type="Ensembl" id="ENSMICT00000028000.2">
        <property type="protein sequence ID" value="ENSMICP00000027343.1"/>
        <property type="gene ID" value="ENSMICG00000008894.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865637"/>
    <dbReference type="KEGG" id="mmur:105865637"/>
    <dbReference type="CTD" id="83743"/>
    <dbReference type="GeneTree" id="ENSGT00550000075124"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000332">
        <property type="entry name" value="glutamate-rich WD repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="14">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="349"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="110"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="446" mass="49283" checksum="4C76D537FF59A62C" modified="2022-01-19" version="1">MAARKGRRRTCETGEPMEAESGDTGPKGSAQVYLPGRGPPLREGEELVMDEEAYVLYHRAQTGAPCLSFDIVRDHLGDNRTELPLTLYLCAGTQAESAQSNRLMMLRMHNLHGTKPPPSEGSDEEEEEEDEEDEEERKPQLELAMVPHYGGINRVRVSWLGEEPVAAIWSEKGQVEVFALRRLLQVVDDPQALATFLRDEQARVKPIFSFAGHMGEGFALDWSSRVPGRLLTGDCQKNIHLWTPTDGGSWHVDQRPFVGHMSSVEDLQWSPTEDTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISWSRREPFLLSGGDDGALKVWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADNQITQWDLAVERDPEAGDAEAEPGLADLPQQLLFVHQGETDLKELHWHPQCPGLLVSTALSGFTVFRTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJV6</accession>
    <name>A0A8C5XJV6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gremlin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GREM1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621789.1">
        <property type="nucleotide sequence ID" value="XM_012766335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJV6"/>
    <dbReference type="Ensembl" id="ENSMICT00000050776.2">
        <property type="protein sequence ID" value="ENSMICP00000030089.2"/>
        <property type="gene ID" value="ENSMICG00000035437.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105872385"/>
    <dbReference type="CTD" id="26585"/>
    <dbReference type="GeneTree" id="ENSGT00940000154209"/>
    <dbReference type="OrthoDB" id="10061784at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036122">
        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030297">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043184">
        <property type="term" value="F:vascular endothelial growth factor receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055007">
        <property type="term" value="P:cardiac muscle cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060379">
        <property type="term" value="P:cardiac muscle cell myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002042">
        <property type="term" value="P:cell migration involved in sprouting angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030199">
        <property type="term" value="P:collagen fibril organization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048263">
        <property type="term" value="P:determination of dorsal identity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003337">
        <property type="term" value="P:mesenchymal to epithelial transition involved in metanephros morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1900158">
        <property type="term" value="P:negative regulation of bone mineralization involved in bone maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046851">
        <property type="term" value="P:negative regulation of bone remodeling"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of bone trabecula formation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0032331">
        <property type="term" value="P:negative regulation of chondrocyte differentiation"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0045668">
        <property type="term" value="P:negative regulation of osteoblast differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033689">
        <property type="term" value="P:negative regulation of osteoblast proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090291">
        <property type="term" value="P:negative regulation of osteoclast proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060392">
        <property type="term" value="P:negative regulation of SMAD protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090190">
        <property type="term" value="P:positive regulation of branching involved in ureteric bud morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090050">
        <property type="term" value="P:positive regulation of cell migration involved in sprouting angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901224">
        <property type="term" value="P:positive regulation of non-canonical NF-kappaB signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002092">
        <property type="term" value="P:positive regulation of receptor internalization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900748">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010717">
        <property type="term" value="P:regulation of epithelial to mesenchymal transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051893">
        <property type="term" value="P:regulation of focal adhesion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038098">
        <property type="term" value="P:sequestering of BMP from receptor via BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060676">
        <property type="term" value="P:ureteric bud formation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Gremlin"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006207">
        <property type="entry name" value="Cys_knot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
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    <dbReference type="InterPro" id="IPR004133">
        <property type="entry name" value="DAN_dom"/>
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    <dbReference type="InterPro" id="IPR017159">
        <property type="entry name" value="Gremlin-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15283">
        <property type="entry name" value="GREMLIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR15283:SF3">
        <property type="entry name" value="GREMLIN-1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PIRSF" id="PIRSF037254">
        <property type="entry name" value="Gremlin_precursor"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00041">
        <property type="entry name" value="CT"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CTCK" evidence="10">
        <location>
            <begin position="122"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="103"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007872"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030089.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="210" mass="23437" checksum="893A9637B39DFC66" modified="2022-01-19" version="1">MHLVCSPISIGSLVMDAECDIGLTRPMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XMS7</accession>
    <name>A0A8C5XMS7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Heterogeneous nuclear ribonucleoprotein D-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC105865601</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XMS7"/>
    <dbReference type="Ensembl" id="ENSMICT00000029691.2">
        <property type="protein sequence ID" value="ENSMICP00000037864.2"/>
        <property type="gene ID" value="ENSMICG00000037040.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154426"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034046">
        <property type="term" value="F:poly(G) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000220">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein D-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000030">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein d0 isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF2">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="114"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="192"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037864.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="220" mass="24962" checksum="4CB41CB24ACC5FB4" modified="2022-01-19" version="1">MEDMKEYSNIEEFAEGSKINASENQQDDGKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLDGKLIDPKRAKALKGKEPPKKVFVGGLSPDTSEEQIKEHFGAFGEIENIELPMDTKTNERRRFCFVTYTDEEPLKKLLESRYHQIGSGKCEIKVAQPKEVYRQQQQQQKGGRGARPRSGPKLEPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XP19</accession>
    <name>A0A8C5XP19_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TRIM7</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRIM/RBCC family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03030985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03030986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XP19"/>
    <dbReference type="Ensembl" id="ENSMICT00000052911.2">
        <property type="protein sequence ID" value="ENSMICP00000038595.2"/>
        <property type="gene ID" value="ENSMICG00000028707.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234669"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140374">
        <property type="term" value="P:antiviral innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13740">
        <property type="entry name" value="SPRY_PRY_TRIM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000025">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM41 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006574">
        <property type="entry name" value="PRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050143">
        <property type="entry name" value="TRIM/RBCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24103">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13765">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00589">
        <property type="entry name" value="PRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="17">
        <location>
            <begin position="119"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038595.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="306" mass="34669" checksum="C2A518929E7C09DB" modified="2022-01-19" version="1">QKQMAAEQEKVGAEFQALRAFLVEQEGRLQGHLEELSREVTQKHKENLTQLAGEISQLSKLCGQIQETAGKPDLDFLQEFKSTLDRCSNVPGPKPTTVSSEMKNKVWNVSLKTFVLKGLLKKFKEDLRGELEKEEKVELTLDPDTANPRLVLSLDLKSVRLGQRAQDLPGHPRRFDTNTRVLASCGFSSGRHHWEVEVGSRDGWAFGVARESVRRKGLTPFTPEEGVWALQLHGGQYWAVTSPERTPLSCARLSRVRVALDLEVGAVSFYAVEDMRHLYTFRVNFQERVFPLFSVCSTGTYLRIWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XP32</accession>
    <name>A0A8C5XP32_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC105882633</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Aminoacyl-tRNA synthetase that catalyzes the specific attachment of leucine to its cognate tRNA (tRNA(Leu)). It performs tRNA aminoacylation in a two-step reaction: Leu is initially activated by ATP to form a leucyl-adenylate (Leu-AMP) intermediate; then the leucyl moiety is transferred to the acceptor 3' end of the tRNA to yield leucyl-tRNA. To improve the fidelity of catalytic reactions, it is also able to hydrolyze misactivated aminoacyl-adenylate intermediates (pre-transfer editing) and mischarged aminoacyl-tRNAs (post-transfer editing).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionyl-tRNA(Leu) + H2O = tRNA(Leu) + L-methionine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:77535"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:18931"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:77536"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:11689"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03010772">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XP32"/>
    <dbReference type="Ensembl" id="ENSMICT00000049893.2">
        <property type="protein sequence ID" value="ENSMICP00000038597.2"/>
        <property type="gene ID" value="ENSMICG00000035435.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012163"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07959">
        <property type="entry name" value="Anticodon_Ia_Leu_AEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000326">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000084">
        <property type="entry name" value="Leucyl-tRNA synthetase b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054509">
        <property type="entry name" value="LARS1_ULD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055416">
        <property type="entry name" value="RBD_LARS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24810">
        <property type="entry name" value="RBD_LARS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22947">
        <property type="entry name" value="ULD_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="558"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="681"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase RagD-binding" evidence="18">
        <location>
            <begin position="814"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase ubiquitin-like" evidence="17">
        <location>
            <begin position="937"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine--tRNA ligase ubiquitin-like" evidence="17">
        <location>
            <begin position="987"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038597.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1028" mass="116861" checksum="50CBF9AD98CD07EF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XRV5</accession>
    <name>A0A8C5XRV5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pro-neuregulin-1, membrane-bound isoform</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">NRG1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="15">The cytoplasmic domain interacts with the LIM domain region of LIMK1. Forms a ternary complex with ERBB3 and ITGAV:ITGB3 or ITGA6:ITGB4. Interacts with NRDC and BACE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the neuregulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023853">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XRV5"/>
    <dbReference type="Ensembl" id="ENSMICT00000061224.1">
        <property type="protein sequence ID" value="ENSMICP00000040538.1"/>
        <property type="gene ID" value="ENSMICG00000015565.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157326"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051094">
        <property type="term" value="P:positive regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010646">
        <property type="term" value="P:regulation of cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023051">
        <property type="term" value="P:regulation of signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05895">
        <property type="entry name" value="Ig_Pro_neuregulin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000263">
        <property type="entry name" value="Pro-neuregulin-1, membrane-bound isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000073">
        <property type="entry name" value="Pro-neuregulin-1, membrane-bound isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
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        <property type="entry name" value="Ig_I-set"/>
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        <property type="entry name" value="Ig_sub"/>
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        <property type="entry name" value="Ig_sub2"/>
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        <property type="entry name" value="Neuregulin"/>
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        <property type="entry name" value="Neuregulin_C"/>
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        <property type="entry name" value="NRG1"/>
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        <property type="entry name" value="HEREGULIN-NEUREGULIN FAMILY MEMBER"/>
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        <property type="entry name" value="PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM"/>
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    </dbReference>
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        <property type="entry name" value="NEUREGULIN"/>
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        <property type="entry name" value="IG"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="IG_LIKE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="11 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="19">
        <location>
            <begin position="176"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="337"/>
            <end position="363"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="379"/>
            <end position="400"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="432"/>
            <end position="464"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="484"/>
            <end position="598"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="17">
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            <begin position="337"/>
            <end position="353"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="354"/>
            <end position="363"/>
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    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="545"/>
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    </feature>
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            <begin position="568"/>
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    </feature>
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        <location>
            <begin position="210"/>
            <end position="219"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008216"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
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    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040538.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="643" mass="70742" checksum="85BC600858BD7574" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XSS1</accession>
    <name>A0A8C5XSS1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Ceramide synthase 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CERS4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + octadecanoyl-CoA = N-(octadecanoyl)-sphinganine + CoA + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:67033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:36548"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027862">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027863">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027864">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646255.1">
        <property type="nucleotide sequence ID" value="XM_012790801.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSS1"/>
    <dbReference type="Ensembl" id="ENSMICT00000061485.1">
        <property type="protein sequence ID" value="ENSMICP00000040857.1"/>
        <property type="gene ID" value="ENSMICG00000014575.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885662"/>
    <dbReference type="KEGG" id="mmur:105885662"/>
    <dbReference type="CTD" id="79603"/>
    <dbReference type="GeneTree" id="ENSGT01030000234515"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000020">
        <property type="entry name" value="Ceramide synthase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
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    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF6">
        <property type="entry name" value="CERAMIDE SYNTHASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LAG1_LAC1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="39"/>
            <end position="56"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="136"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
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            <begin position="259"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
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            <end position="328"/>
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    </feature>
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        <location>
            <begin position="84"/>
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        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="12">
        <location>
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            <end position="129"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="395" mass="46472" checksum="6E8133EAD466DB9A" modified="2022-01-19" version="1">MLSTFNEWLWQDRFWLPPNTSWAQLEDRDGLVYAHPRDMLAALPLALALLALRVTFERFVGLPLSRLLGVRDHTRRPAKPNPTLERHFLTDGPRPKEPQLTLLAAQCGLTLRQTQRWFRRRRNQDRPRLTKKFCEACWRFVFYLCAFVGGVSVLYHESWLWTPARCWDNYPYQTLKPALYWWYILELGFYISLLITLPFDVKRKDFKEQVLHHFVTILLMTFSYSSNLLRIGSLVLLLHDSSDYLLEACKMFNYTRYRLVCDTLFVVFSLVFFYTRLVLFPTQILYTTYYDSIVNWTPFFAYYFFNALLVMLQLLHVFWSCLILRMLYSFVRKGQMEKDVRSDVESSDSEEEEEEKKAARECPQLKNGAARGPAAADGARSRVAGRLANGHTPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZM4</accession>
    <name>A0A8C5XZM4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Otoraplin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">OTOR</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MIA/OTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614978.1">
        <property type="nucleotide sequence ID" value="XM_012759524.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZM4"/>
    <dbReference type="Ensembl" id="ENSMICT00000062178.1">
        <property type="protein sequence ID" value="ENSMICP00000043226.1"/>
        <property type="gene ID" value="ENSMICG00000043592.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105868531"/>
    <dbReference type="KEGG" id="mmur:105868531"/>
    <dbReference type="CTD" id="56914"/>
    <dbReference type="GeneTree" id="ENSGT00950000182767"/>
    <dbReference type="OrthoDB" id="6627676at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001502">
        <property type="term" value="P:cartilage condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11891">
        <property type="entry name" value="MIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000175">
        <property type="entry name" value="Melanoma-derived growth regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042801">
        <property type="entry name" value="OTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035554">
        <property type="entry name" value="Otoraplin_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47146">
        <property type="entry name" value="OTORAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47146:SF1">
        <property type="entry name" value="OTORAPLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 7" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150406" evidence="8">
        <location>
            <begin position="21"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="128" mass="14500" checksum="78A3070719ACC349" modified="2022-01-19" version="1">MARILSLFLLGLAAVCAVHGMFMDRLSSKKLCADDECVYTISLARAQEDYNAPDCRFINVKKGQQIYVYSKLVKENEAGEFWAGSVYGDDQDEMGIVGYFPSNLVKEQRVYQEATREVPTTDIDFFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y001</accession>
    <name>A0A8C5Y001_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">All-trans-retinol dehydrogenase [NAD(+)] ADH7</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
            <ecNumber evidence="23">1.1.1.105</ecNumber>
            <ecNumber evidence="24">1.1.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Alcohol dehydrogenase class 4 mu/sigma chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Alcohol dehydrogenase class IV mu/sigma chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Gastric alcohol dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Omega-hydroxydecanoate dehydrogenase ADH7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Retinol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">ADH7</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-4-hydroxynon-2-en-1-ol + NAD(+) = (E)-4-hydroxynon-2-enal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60976"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58968"/>
            <dbReference type="ChEBI" id="CHEBI:142617"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:60978"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(E)-hex-2-en-1-ol + NAD(+) = (E)-hex-2-enal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60988"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28913"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:141205"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:60989"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:60990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20880"/>
            <dbReference type="ChEBI" id="CHEBI:11305"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58022"/>
            <dbReference type="EC" id="1.1.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:20881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>12-hydroxydodecanoate + NAD(+) = 12-oxododecanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60980"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36204"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:144067"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:60981"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>16-hydroxyhexadecanoate + NAD(+) = 16-oxohexadecanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60984"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55329"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:144068"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:60985"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>9-cis-retinol + NAD(+) = 9-cis-retinal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42052"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78272"/>
            <dbReference type="ChEBI" id="CHEBI:78273"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:42053"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:10737"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:10738"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-3,4-didehydroretinol + NAD(+) = all-trans-3,4-didehydroretinal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55940"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28537"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132246"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:55941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>all-trans-4-hydroxyretinol + NAD(+) = all-trans-4-hydroxyretinal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132259"/>
            <dbReference type="ChEBI" id="CHEBI:139346"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:55937"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>all-trans-4-oxoretinol + NAD(+) = all-trans-4-oxoretinal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60632"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:44597"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:139347"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="19">
            <dbReference type="Rhea" id="RHEA:60634"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>all-trans-retinol + NAD(+) = all-trans-retinal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.105"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:21285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>hexan-1-ol + NAD(+) = hexanal + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60972"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:87393"/>
            <dbReference type="ChEBI" id="CHEBI:88528"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:60973"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:60974"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 31">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EC" id="1.1.1.105" evidence="23"/>
    <dbReference type="EC" id="1.1.1.66" evidence="24"/>
    <dbReference type="EMBL" id="ABDC03031281">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y001"/>
    <dbReference type="Ensembl" id="ENSMICT00000070308.1">
        <property type="protein sequence ID" value="ENSMICP00000043847.1"/>
        <property type="gene ID" value="ENSMICG00000003495.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162708"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 29"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050153">
        <property type="term" value="F:omega-hydroxydecanoate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006068">
        <property type="term" value="P:ethanol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042573">
        <property type="term" value="P:retinoic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08299">
        <property type="entry name" value="alcohol_DH_class_I_II_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001857">
        <property type="entry name" value="Alcohol dehydrogenase class 4 mu/sigma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF2">
        <property type="entry name" value="ALL-TRANS-RETINOL DEHYDROGENASE [NAD(+)] ADH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 31" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="33">
        <location>
            <begin position="37"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="32">
        <location>
            <begin position="205"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00052287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00052388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00066603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00066654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00067656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00077559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00079085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00079816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00080157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00081351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="377" mass="40440" checksum="2E0099F93249CD34" modified="2022-01-19" version="1">GAFQGRPVQVIKCKAAVLWEQNKPFSIEEIEVAPPKAKEVRIKILATGICRTDDHVIKGAMVSKFPVIVGHEATGVVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDVTGRGVLADGTTRFTCRGRPVHHFMNTSTFTEYTVLDESSVAKIEAAAPPEKVCLIGCGFSTGYGAAVKTAKVTPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECLSPKDCTKPIGEVLSEMTGNTVNYSFEVIGRLETMVDALASCHMNYGTSVVVGAPPSAKMLTYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTDFLAKKFDLDQLITHVLPFKDINKGFELLYSGQSIRTVLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y215</accession>
    <name>A0A8C5Y215_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive rhomboid protein</fullName>
            <shortName evidence="14">iRhom</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Rhomboid family member</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Rhomboid veinlet-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">RHBDF1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 14">Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer, or homooligomer. Interacts with TGFA and HBEGF. Interacts with EGF; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD). Interacts (via cytoplasmic N-terminus) with FRMD8/iTAP; this interaction leads to mutual protein stabilization. Interacts with ADAM17/TACE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020756">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136962.1">
        <property type="nucleotide sequence ID" value="XM_020281373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y215"/>
    <dbReference type="Ensembl" id="ENSMICT00000061047.1">
        <property type="protein sequence ID" value="ENSMICP00000044467.1"/>
        <property type="gene ID" value="ENSMICG00000010336.3"/>
    </dbReference>
    <dbReference type="CTD" id="64285"/>
    <dbReference type="GeneTree" id="ENSGT00940000156278"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019838">
        <property type="term" value="F:growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050709">
        <property type="term" value="P:negative regulation of protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042058">
        <property type="term" value="P:regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000001">
        <property type="entry name" value="Putative inactive rhomboid protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051512">
        <property type="entry name" value="Inactive_Rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022241">
        <property type="entry name" value="iRhom1_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45965:SF4">
        <property type="entry name" value="INACTIVE RHOMBOID PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12595">
        <property type="entry name" value="iRhom1-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0340">Growth factor binding</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="716"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="777"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="807"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="833"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="864"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Inactive rhomboid protein 1/2 N-terminal" evidence="17">
        <location>
            <begin position="151"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="16">
        <location>
            <begin position="711"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="915" mass="104014" checksum="79DC92131611ADF1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y267</accession>
    <name>A0A8C5Y267_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ras-related protein Rab-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">RAB3A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Lipid-anchor</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027632">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y267"/>
    <dbReference type="Ensembl" id="ENSMICT00000066781.1">
        <property type="protein sequence ID" value="ENSMICP00000044759.1"/>
        <property type="gene ID" value="ENSMICG00000047037.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158959"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048786">
        <property type="term" value="C:presynaptic active zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043195">
        <property type="term" value="C:terminal bouton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030742">
        <property type="term" value="F:GTP-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031489">
        <property type="term" value="F:myosin V binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060478">
        <property type="term" value="P:acrosomal vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061670">
        <property type="term" value="P:evoked neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048790">
        <property type="term" value="P:maintenance of presynaptic active zone structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007274">
        <property type="term" value="P:neuromuscular synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001778">
        <property type="term" value="P:plasma membrane repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903307">
        <property type="term" value="P:positive regulation of regulated secretory pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905684">
        <property type="term" value="P:regulation of plasma membrane repair"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099161">
        <property type="term" value="P:regulation of presynaptic dense core granule exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048172">
        <property type="term" value="P:regulation of short-term neuronal synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031630">
        <property type="term" value="P:regulation of synaptic vesicle fusion to presynaptic active zone membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003016">
        <property type="term" value="P:respiratory system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051602">
        <property type="term" value="P:response to electrical stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050975">
        <property type="term" value="P:sensory perception of touch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097091">
        <property type="term" value="P:synaptic vesicle clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016188">
        <property type="term" value="P:synaptic vesicle maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048489">
        <property type="term" value="P:synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01865">
        <property type="entry name" value="Rab3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000206">
        <property type="entry name" value="Ras-related protein Rab-3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037872">
        <property type="entry name" value="Rab3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="220" mass="24956" checksum="1A3E9F8C9BD2EB40" modified="2022-01-19" version="1">MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLSDQQAPPHQDCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y296</accession>
    <name>A0A8C5Y296_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">LOC105876634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005259">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y296"/>
    <dbReference type="Ensembl" id="ENSMICT00000058551.1">
        <property type="protein sequence ID" value="ENSMICP00000044504.1"/>
        <property type="gene ID" value="ENSMICG00000046528.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183000"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00006">
        <property type="entry name" value="COFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="136" mass="15263" checksum="E8DCCE0BA3CAB188" modified="2022-01-19" version="1">MLHTRRNQKKKEGMFCLSADKKCIIILVGDVGVTITDPFKNFVGMLPEKDCHYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNQACIAEKLGGSLIVAFEGCPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4E0</accession>
    <name>A0A8C5Y4E0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LOC105882862</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026410">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4E0"/>
    <dbReference type="Ensembl" id="ENSMICT00000070151.1">
        <property type="protein sequence ID" value="ENSMICP00000046073.1"/>
        <property type="gene ID" value="ENSMICG00000004597.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286907"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033691">
        <property type="term" value="F:sialic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000829">
        <property type="entry name" value="Sialic acid-binding Ig-like lectin 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051036">
        <property type="entry name" value="SIGLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035">
        <property type="entry name" value="SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12035:SF125">
        <property type="entry name" value="SIALIC ACID-BINDING IG-LIKE LECTIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="153"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="15">
        <location>
            <begin position="243"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="573"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="582" mass="61899" checksum="F79D61F80FF8A73C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7L7</accession>
    <name>A0A8C5Y7L7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-ketoglutarate-dependent dioxygenase FTO</fullName>
            <ecNumber evidence="5">1.14.11.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Fat mass and obesity-associated protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">mRNA N(6)-methyladenosine demethylase FTO</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA N1-methyl adenine demethylase FTO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">FTO</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>N(6)-methyladenosine in U6 snRNA + 2-oxoglutarate + O2 = adenosine in U6 snRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57900"/>
            <dbReference type="Rhea" id="RHEA-COMP:13573"/>
            <dbReference type="Rhea" id="RHEA-COMP:13574"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57904"/>
            <dbReference type="Rhea" id="RHEA-COMP:15030"/>
            <dbReference type="Rhea" id="RHEA-COMP:15031"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85958"/>
            <dbReference type="ChEBI" id="CHEBI:85959"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:57896"/>
            <dbReference type="Rhea" id="RHEA-COMP:11518"/>
            <dbReference type="Rhea" id="RHEA-COMP:11519"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85958"/>
            <dbReference type="ChEBI" id="CHEBI:85959"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>an N(1)-methyladenosine in tRNA + 2-oxoglutarate + O2 = an adenosine in tRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54576"/>
            <dbReference type="Rhea" id="RHEA-COMP:10242"/>
            <dbReference type="Rhea" id="RHEA-COMP:12312"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Monomer. May also exist as homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fto family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03024435">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7L7"/>
    <dbReference type="SMR" id="A0A8C5Y7L7"/>
    <dbReference type="Ensembl" id="ENSMICT00000069401.1">
        <property type="protein sequence ID" value="ENSMICP00000047022.1"/>
        <property type="gene ID" value="ENSMICG00000016837.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017730"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990984">
        <property type="term" value="F:tRNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060612">
        <property type="term" value="P:adipose tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090335">
        <property type="term" value="P:regulation of brown fat cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040014">
        <property type="term" value="P:regulation of multicellular organism growth"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044065">
        <property type="term" value="P:regulation of respiratory system process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070350">
        <property type="term" value="P:regulation of white fat cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001659">
        <property type="term" value="P:temperature homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="FTO, alpha-ketoglutarate dependent dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000001">
        <property type="entry name" value="FTO, alpha-ketoglutarate dependent dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1470">
        <property type="entry name" value="FTO C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032868">
        <property type="entry name" value="FTO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024366">
        <property type="entry name" value="FTO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038413">
        <property type="entry name" value="FTO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024367">
        <property type="entry name" value="FTO_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31291">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31291:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE FTO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12934">
        <property type="entry name" value="FTO_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12933">
        <property type="entry name" value="FTO_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01223">
        <property type="entry name" value="FTO_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase FTO catalytic" evidence="26">
        <location>
            <begin position="35"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030546"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032169"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032950"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046452"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="SMART" id="SM01223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="522" mass="60323" checksum="16DFC1471CB81CC1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y882</accession>
    <name>A0A8C5Y882_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GAGE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAGE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036686">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y882"/>
    <dbReference type="Ensembl" id="ENSMICT00000064401.1">
        <property type="protein sequence ID" value="ENSMICP00000046564.1"/>
        <property type="gene ID" value="ENSMICG00000041771.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153097"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031320">
        <property type="entry name" value="GAGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008625">
        <property type="entry name" value="GAGE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14047">
        <property type="entry name" value="P ANTIGEN FAMILY MEMBER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14047:SF33">
        <property type="entry name" value="X ANTIGEN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01379">
        <property type="entry name" value="GAGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAGE" evidence="3">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="11978" checksum="4A273666C472F295" modified="2022-01-19" version="1">MSHRGRSTYRPRPRRNDQEFCQRIGAAHQPRDEEPPQEEPPTGIQGVTPGQKRDAGAPEIQGPDLEADTQELSQPETGVECLGPDVKEESLPTLKPTEVLEAGIQGRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAA6</accession>
    <name>A0A8C5YAA6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Receptor transporter protein 5 (putative)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RTP5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010568">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAA6"/>
    <dbReference type="Ensembl" id="ENSMICT00000069404.1">
        <property type="protein sequence ID" value="ENSMICP00000047650.1"/>
        <property type="gene ID" value="ENSMICG00000045438.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163732"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031849">
        <property type="term" value="F:olfactory receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001580">
        <property type="term" value="P:detection of chemical stimulus involved in sensory perception of bitter taste"/>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Liu Y."/>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Methyltransferase-like protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">METTL1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a complex with WDR4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">Phosphorylation at Ser-28 inactivates its catalytic activity but does not affect the interaction with WDR4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03009713">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632599.1">
        <property type="nucleotide sequence ID" value="XM_012777145.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632600.1">
        <property type="nucleotide sequence ID" value="XM_012777146.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632602.1">
        <property type="nucleotide sequence ID" value="XM_012777148.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YC57"/>
    <dbReference type="SMR" id="A0A8C5YC57"/>
    <dbReference type="Ensembl" id="ENSMICT00000059705.1">
        <property type="protein sequence ID" value="ENSMICP00000049542.1"/>
        <property type="gene ID" value="ENSMICG00000045368.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105878003"/>
    <dbReference type="KEGG" id="mmur:105878003"/>
    <dbReference type="CTD" id="4234"/>
    <dbReference type="GeneTree" id="ENSGT00390000017840"/>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106143">
        <property type="term" value="C:tRNA (m7G46) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160090">
        <property type="term" value="F:internal mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036416">
        <property type="term" value="P:tRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000060">
        <property type="entry name" value="tRNA (guanine-N(7)-)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="239"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by PKB and RPS6KA3" evidence="11">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="278" mass="31674" checksum="D80DA1B4970B2957" modified="2022-01-19" version="1">MAGAESFDAAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLTQNQSHDDSKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFRKGQLTKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTITDVLELHDWMCTHFEGHPLFERVSLEELTEDPIVRHLGTSTEEGKKVLRNGGKNFPAIFRRIQDPALQTVTPSPTLPGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YCK1</accession>
    <name>A0A8C5YCK1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Family with sequence similarity 240 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FAM240A</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018154">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YCK1"/>
    <dbReference type="Ensembl" id="ENSMICT00000060576.1">
        <property type="protein sequence ID" value="ENSMICP00000049382.1"/>
        <property type="gene ID" value="ENSMICG00000043115.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000069333"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040261">
        <property type="entry name" value="FAM240"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40387:SF3">
        <property type="entry name" value="PROTEIN FAM240A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40387">
        <property type="entry name" value="PROTEIN FAM240B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="87" mass="10560" checksum="25584A058016F06B" modified="2022-01-19" version="1">MGSHPSLGEGMNNQYARREVFCRNTCHELKRFWEREIGKQTCYRESEEHRLGRSALRRLREEWKQRLETKLRLRNNPDETEKRANVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YDP7</accession>
    <name>A0A8C5YDP7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030180">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03030181">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YDP7"/>
    <dbReference type="Ensembl" id="ENSMICT00000067330.1">
        <property type="protein sequence ID" value="ENSMICP00000048773.1"/>
        <property type="gene ID" value="ENSMICG00000033202.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155021"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF141">
        <property type="entry name" value="CYTOCHROME P450 CYP4F13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034943936" evidence="2">
        <location>
            <begin position="17"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="493" mass="54447" checksum="8FC1A4699031D465" modified="2022-01-19" version="1">MPQLSLSWLGLGPAAASPWLLLLLLGASWLLARVLAWACAFHATCRRLRCFPQPPKRSWFWGHQGLVSNNEEGMRLIEDLGHHFRDVHLWWIGPFYPVLRLVHPKFVAPLLQASAAIIPKDRTLYSFLRPWLGDGLLLSAGDKWSRHRRMLTPAFHFDILKPYVQIFNQASGSAVLDNVSHITTSSLAGPCRRPSEYIAATLELSALIMKRHQRVLLHADLLYHLTPDGRRFRRACALVHGFTDAVVRERRRALESQGVDGFLKAKAKSKTLDFIDVLLLAKDEDGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPDYQERCRQEVRELLRGREPEDPAPAAFLTCCIKEGLRLHPQATAHSCPQAGTKDVGAHRADGGSPFSVCIIASLGFIHNPSVWPSSLDPATDCLGWVPGASLSHLVRPRNCIGAGPCHGRRMKVGPGAPPCCAFRVLPGHHGAAQGSRKYPAAAEGGLCWRVEALSACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YIX8</accession>
    <name>A0A8C5YIX8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SRY-box transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SOX2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03000927">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592429.1">
        <property type="nucleotide sequence ID" value="XM_012736975.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YIX8"/>
    <dbReference type="SMR" id="A0A8C5YIX8"/>
    <dbReference type="Ensembl" id="ENSMICT00000072911.1">
        <property type="protein sequence ID" value="ENSMICP00000051514.1"/>
        <property type="gene ID" value="ENSMICG00000049239.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105855800"/>
    <dbReference type="KEGG" id="mmur:105855800"/>
    <dbReference type="CTD" id="6657"/>
    <dbReference type="GeneTree" id="ENSGT00940000160614"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001714">
        <property type="term" value="P:endodermal cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048839">
        <property type="term" value="P:inner ear development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902807">
        <property type="term" value="P:negative regulation of cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021983">
        <property type="term" value="P:pituitary gland development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070848">
        <property type="term" value="P:response to growth factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01388">
        <property type="entry name" value="HMG-box_SoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000002">
        <property type="entry name" value="transcription factor Sox-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022097">
        <property type="entry name" value="SOX_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF231">
        <property type="entry name" value="TRANSCRIPTION FACTOR SOX-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12336">
        <property type="entry name" value="SOXp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="9">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="7">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="320" mass="34481" checksum="C6F7BA47AD103B78" modified="2022-01-19" version="1">MYNMMETELKPPGPQQTSGGGGGGGGNSTAAAAGGNQKNSPDRVKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSETEKRPFIDEAKRLRALHMKEHPDYKYRPRRKTKTLMKKDKYTLPGGLLAPGGNSMASGVGVGAGLGAGVNQRMDSYAHMNGWSNGSYSMMQDQLGYPQHPGLNAHGAAQMQPMHRYDVSALQYNSMTSSQTYMNGSPTYSMSYSQQGTPGMALGSMGSVVKSEASSSPPVVTSSSHSRAPCQAGDLRDMISMYLPGAEVPEPAAPSRLHMSQHYQSGPVPGTAINGTLPLSHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EDP6</accession>
    <name>A0A8C6EDP6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Olfactory receptor family 5 subfamily AU member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">OR5AU1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03004419">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EDP6"/>
    <dbReference type="Ensembl" id="ENSMICT00000037998.2">
        <property type="protein sequence ID" value="ENSMICP00000039319.2"/>
        <property type="gene ID" value="ENSMICG00000038048.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01040000240383"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="70"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039319.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="293" mass="32782" checksum="549BF9276294AFDA" modified="2022-01-19" version="1">REGFHLKQLSQISSIRLIFRRLSIAASGCSTSFTMLPSFHTPEHWRNMEWANLSQVTEFELLGLTSDVQLQRLLFLVFPGMYTISVATLHTPMYSFLKSHSFLDFCYSSTVVPQTLVNFLAKRKVLSYLGCMAQMFFFAGFTTSECYLIAAMAYVRYAAICNPLLYPTIMSPEICASLIIGSYNGGFLNSLIHTSCIFSLNFCGADVVTHFFCDGPPILSPSCGDTSLCEILLFIFAGFNILSCILTILISYFLILIAILKMNSAQGKFNYSLTQDHTVAVIYTVVIPMKTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EI64</accession>
    <name>A0A8C6EI64_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFAP298 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019049">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EI64"/>
    <dbReference type="Ensembl" id="ENSMICT00000063296.1">
        <property type="protein sequence ID" value="ENSMICP00000043681.1"/>
        <property type="gene ID" value="ENSMICG00000044167.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006278"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003352">
        <property type="term" value="P:regulation of cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021298">
        <property type="entry name" value="CFAP298"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238:SF0">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13238">
        <property type="entry name" value="PROTEIN C21ORF59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11069">
        <property type="entry name" value="CFAP298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="234" mass="27480" checksum="AAAA6D55A09092E1" modified="2022-01-19" version="1">MVSLHVSESQLLLQAPESTELEELRVQVAHVHHYNWRLKVQHLCSEMEELPGHGVFLPPNMQGLTDDQIEELKLRDEWGEKCMPSWGLVNRQAPNEKMKQVLKKTIEEAKAIISKKQVEARVCITMEMVKDALDQLRWAVMIVYPMGLPSYDPIRMEFENKICQELRGQGALAREPIISSEEQKQLMLYYHRRQEELKRLEENDDDTCLNSPWADNTALKRHFHGVKDKKWRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EJJ6</accession>
    <name>A0A8C6EJJ6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024677">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EJJ6"/>
    <dbReference type="Ensembl" id="ENSMICT00000065071.1">
        <property type="protein sequence ID" value="ENSMICP00000047174.1"/>
        <property type="gene ID" value="ENSMICG00000042472.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153474"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000442">
        <property type="entry name" value="Immunoglobulin lambda variable 2-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="117" mass="12021" checksum="862696DBF9F0278A" modified="2022-01-19" version="1">QSALTQPPSVSGAPGQSVTISCSGSSSNIGGNYVHWHQQLPGTAPKLLIYGNSNRPSGVPARFSGSKSGSSASLTIAGLQAEDEGDYYCSSWDSSLSGHTVLQAQGEVRQKPAPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKY5</accession>
    <name>A0A8C6EKY5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M12B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023987">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKY5"/>
    <dbReference type="Ensembl" id="ENSMICT00000058806.1">
        <property type="protein sequence ID" value="ENSMICP00000049420.1"/>
        <property type="gene ID" value="ENSMICG00000047697.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162466"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007339">
        <property type="term" value="P:binding of sperm to zona pellucida"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008584">
        <property type="term" value="P:male gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04269">
        <property type="entry name" value="ZnMc_adamalysin_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034027">
        <property type="entry name" value="Reprolysin_adamalysin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF26">
        <property type="entry name" value="A DISINTEGRIN AND METALLOPEPTIDASE DOMAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01421">
        <property type="entry name" value="Reprolysin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034895634" description="Peptidase M12B domain-containing protein" evidence="3">
        <location>
            <begin position="28"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="4">
        <location>
            <begin position="15"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="2">
        <location>
            <begin position="131"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="155" mass="17747" checksum="37A5E4408C1D31E9" modified="2022-01-19" version="1">MVTQTCVTCIFCFQMFFQLKMTIMLSSLEVWSDQSKISTSGDVDELLQRFLSWKQKFSFQRFRDMAYLLIYRDHLIHVGATYHGMACDPKFAAGVALYSKRITLEAFSVVLVQLLGINLGLTYDNIYNCYCQGATCIMSPEAIFLAVAAWMNLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6ELI5</accession>
    <name>A0A8C6ELI5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NF-kappa-B inhibitor zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">I-kappa-B-zeta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">IL-1 inducible nuclear ankyrin-repeat protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Molecule possessing ankyrin repeats induced by lipopolysaccharide</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NFKBIZ</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with NFKB1/p50. Interacts with RELA. Interacts with AKIRIN2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001246">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635110.1">
        <property type="nucleotide sequence ID" value="XM_012779656.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6ELI5"/>
    <dbReference type="Ensembl" id="ENSMICT00000072450.1">
        <property type="protein sequence ID" value="ENSMICP00000050608.1"/>
        <property type="gene ID" value="ENSMICG00000048907.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879432"/>
    <dbReference type="KEGG" id="mmur:105879432"/>
    <dbReference type="CTD" id="64332"/>
    <dbReference type="GeneTree" id="ENSGT00940000153695"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036464">
        <property type="term" value="C:cytoplasmic ribonucleoprotein granule"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070974">
        <property type="term" value="F:POU domain binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990117">
        <property type="term" value="P:B cell receptor apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097398">
        <property type="term" value="P:cellular response to interleukin-17"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0002544">
        <property type="term" value="P:chronic inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904019">
        <property type="term" value="P:epithelial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097194">
        <property type="term" value="P:execution phase of apoptosis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048873">
        <property type="term" value="P:homeostasis of number of cells within a tissue"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0090594">
        <property type="term" value="P:inflammatory response to wounding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045190">
        <property type="term" value="P:isotype switching"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032980">
        <property type="term" value="P:keratinocyte activation"/>
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    <dbReference type="GO" id="GO:0030216">
        <property type="term" value="P:keratinocyte differentiation"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0043616">
        <property type="term" value="P:keratinocyte proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042789">
        <property type="term" value="P:mRNA transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002317">
        <property type="term" value="P:plasma cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050729">
        <property type="term" value="P:positive regulation of inflammatory response"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000321">
        <property type="term" value="P:positive regulation of T-helper 17 cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072718">
        <property type="term" value="P:response to cisplatin"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051593">
        <property type="term" value="P:response to folic acid"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140459">
        <property type="term" value="P:response to Gram-positive bacterium"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002456">
        <property type="term" value="P:T cell mediated immunity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045063">
        <property type="term" value="P:T-helper 1 cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072539">
        <property type="term" value="P:T-helper 17 cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002224">
        <property type="term" value="P:toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000179">
        <property type="entry name" value="NF-kappa-B inhibitor zeta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000188">
        <property type="entry name" value="NF-kappa-B inhibitor zeta isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047571">
        <property type="entry name" value="OCA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24124:SF5">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52003">
        <property type="entry name" value="OCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="476"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="609"/>
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    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="645"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="159"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="83"/>
            <end position="96"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023043"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00064472"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071909"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00075776"/>
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    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00077511"/>
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    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078782"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="715" mass="78040" checksum="A34E1E047A9678C8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6ELT9</accession>
    <name>A0A8C6ELT9_MICMU</name>
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        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B15 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFB4</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001099">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636003.1">
        <property type="nucleotide sequence ID" value="XM_012780549.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6ELT9"/>
    <dbReference type="Ensembl" id="ENSMICT00000072771.1">
        <property type="protein sequence ID" value="ENSMICP00000051256.1"/>
        <property type="gene ID" value="ENSMICG00000049509.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879910"/>
    <dbReference type="KEGG" id="mmur:105879910"/>
    <dbReference type="CTD" id="4710"/>
    <dbReference type="GeneTree" id="ENSGT00390000007133"/>
    <dbReference type="OMA" id="REYLLHY"/>
    <dbReference type="OrthoDB" id="5818798at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009866">
        <property type="entry name" value="NADH_UbQ_OxRdtase_NDUFB4_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15469">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B15 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07225">
        <property type="entry name" value="NDUF_B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="129" mass="15219" checksum="41ACD05504DEFD3F" modified="2022-01-19" version="1">MSFPKYIPSRLATLPPTLDPAEYNISPETRRAQAERLAIRARLKREYLLQYNDPDRRGLIEDPALTRWTYARSTNIYPNFRPTPKNSLLGAVCGIGPLFFWYYVFKTDRDRKEKLIQEGKLERTFNISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EA56</accession>
    <name>A0A8B7EA56_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TMEM70</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012841">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590816.1">
        <property type="nucleotide sequence ID" value="XM_012735362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EA56"/>
    <dbReference type="Ensembl" id="ENSMICT00000052243.2">
        <property type="protein sequence ID" value="ENSMICP00000023618.1"/>
        <property type="gene ID" value="ENSMICG00000027905.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105854797"/>
    <dbReference type="KEGG" id="mmur:105854797"/>
    <dbReference type="CTD" id="54968"/>
    <dbReference type="GeneTree" id="ENSGT00390000018710"/>
    <dbReference type="OrthoDB" id="156886at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030061">
        <property type="term" value="C:mitochondrial crista"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140260">
        <property type="term" value="F:mitochondrial proton-transporting ATP synthase complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009724">
        <property type="entry name" value="TMEM70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045325">
        <property type="entry name" value="TMEM70/TMEM186/TMEM223"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13281:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 70, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06979">
        <property type="entry name" value="TMEM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="257" mass="28245" checksum="92E6A138EDFDA6D1" modified="2022-01-19" version="1">MLLLALGVRRASGLRLCCKRTALWAASAPQSPRAAVSGAASCSALSGPVGGGSAGLRGAATFLWRPGRAQIPVCWEGSVRCSHTQPDKSEDGRLIYTGNLARVVFGVKCFSYSTSVISLACLPYFLTQNIILSENLPLQILFFGIIGSFTVITPMLLHFVTKGYVIRLYHEAATDTYKAITYNVVLSETSTVFHQNDVKIPDSTHMFTTFFAKTKSLLVNPVLFPDPEDYIHLMGYDKPFTFDMEETSENKQVKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EC75</accession>
    <name>A0A8B7EC75_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LOC105855493</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004153">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591961.1">
        <property type="nucleotide sequence ID" value="XM_012736507.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EC75"/>
    <dbReference type="Ensembl" id="ENSMICT00000055765.2">
        <property type="protein sequence ID" value="ENSMICP00000044433.1"/>
        <property type="gene ID" value="ENSMICG00000039090.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105855493"/>
    <dbReference type="GeneTree" id="ENSGT00390000012799"/>
    <dbReference type="OrthoDB" id="15794at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="ARSENITE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675:SF1">
        <property type="entry name" value="RIKEN CDNA 2700097O09 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34468" checksum="487C90E8E683CF22" modified="2022-01-19" version="1">MELPSAKRAILQLLRNVAPADCPALLQWMRTTRDFDEFTQDNNDVMLKSIAEDLRNCLPLETMLSSEHLALQKIQQQPDPTVHVDAFLYDEDLIDSLCEEGKMSRNYCMVCGSHQTAPLGFISHSFSLMELKFIYHHVLPDLSGKVLVDVGSRLGTVLYGGYFYSSAVQLYGVELNGDFCQLQEMIIKKYHFTDRIKVLHEDICTQGLLLQNADVVIMNNVFEYFLNEAEQARAWEYISHNVRKQGSLLVTVPSLKDSLSGLQTNIQLSLWIEEVPLNYDVYAEKDIDREALEQIHLYKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ENY9</accession>
    <name>A0A8B7ENY9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Sialidase-1</fullName>
            <ecNumber evidence="7">3.2.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Acetylneuraminyl hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Lysosomal sialidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="24">N-acetyl-alpha-neuraminidase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28 30" type="primary">NEU1</name>
    </gene>
    <organism evidence="30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="30">Liver</tissue>
        </source>
    </reference>
    <reference evidence="28" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of alpha-(2-&gt;3)-, alpha-(2-&gt;6)-, alpha-(2-&gt;8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.</text>
            <dbReference type="EC" id="3.2.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Interacts with cathepsin A (protective protein), beta-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Lysosome lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Lysosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 33 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.18" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03007276">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596623.1">
        <property type="nucleotide sequence ID" value="XM_012741169.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ENY9"/>
    <dbReference type="Ensembl" id="ENSMICT00000003565.3">
        <property type="protein sequence ID" value="ENSMICP00000003244.2"/>
        <property type="gene ID" value="ENSMICG00000003563.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858185"/>
    <dbReference type="CTD" id="4758"/>
    <dbReference type="GeneTree" id="ENSGT00950000182944"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043202">
        <property type="term" value="C:lysosomal lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004308">
        <property type="term" value="F:exo-alpha-sialidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006689">
        <property type="term" value="P:ganglioside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.10:FF:000003">
        <property type="entry name" value="Neuraminidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026856">
        <property type="entry name" value="Sialidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628">
        <property type="entry name" value="SIALIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10628:SF25">
        <property type="entry name" value="SIALIDASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sialidase" evidence="27">
        <location>
            <begin position="89"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00038519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00040509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00041332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00041413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00076983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003244.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="RefSeq" id="XP_012596623.1"/>
        </source>
    </evidence>
    <sequence length="416" mass="45366" checksum="5625EA2AC0512E66" modified="2022-01-19" version="1">MTGGRPGTALLGTPRGPRMPGFWGRCGVQALAAVFLLLLSPAEFRTRAKDDFGLVRPLVTMEQLLWVSGRQIGSVDTFRIPLITTTPRGTLLAFAEARKMSSSDKGAKFIALRRSMDQGSTWSPTEFIVDDGETPDGLNLGAVVSDIETGVVFLFYSLCAHKAGCPVASTMLVWSKDDGVSWSPPRNLSLEIGTEMFAPGPGSGIQKQWEPRKGRLIVCGHGTLERDGVFCLLSDDHGASWSYGGGVRGIPYGQPKREKDFNPDECQPYELPDGSVVINARNQNNYHCRCRIVLRSYDACDTLRTRDVTFDPELVDPVVAAGAVATSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWQKEKVQLWPGPSGYSSLAALEGSMGGEEQGPQLYILYEKGRARYAESISVARISVYGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ER13</accession>
    <name>A0A8B7ER13_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Zinc finger with KRAB and SCAN domains 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZKSCAN3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ER13"/>
    <dbReference type="Ensembl" id="ENSMICT00000010459.3">
        <property type="protein sequence ID" value="ENSMICP00000009526.3"/>
        <property type="gene ID" value="ENSMICG00000010491.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000010490.3">
        <property type="protein sequence ID" value="ENSMICP00000009555.2"/>
        <property type="gene ID" value="ENSMICG00000010491.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163682"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007040">
        <property type="term" value="P:lysosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000773">
        <property type="term" value="P:negative regulation of cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07936">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4020.10:FF:000001">
        <property type="entry name" value="zinc finger protein 263 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000761">
        <property type="entry name" value="Zinc finger protein 449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002004">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001214">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001333">
        <property type="entry name" value="Zinc finger with KRAB and SCAN domains 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4020.10">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003309">
        <property type="entry name" value="SCAN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038269">
        <property type="entry name" value="SCAN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF366">
        <property type="entry name" value="ZINC FINGER PROTEIN ZFP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02023">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00431">
        <property type="entry name" value="SCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47353">
        <property type="entry name" value="Retrovirus capsid dimerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50804">
        <property type="entry name" value="SCAN_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SCAN box" evidence="17">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="376"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009526.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="525" mass="59571" checksum="1A61D5B082BE95E5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ERH2</accession>
    <name>A0A8B7ERH2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MLX interacting protein like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MLXIPL</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597706.1">
        <property type="nucleotide sequence ID" value="XM_012742252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ERH2"/>
    <dbReference type="Ensembl" id="ENSMICT00000054619.2">
        <property type="protein sequence ID" value="ENSMICP00000018653.2"/>
        <property type="gene ID" value="ENSMICG00000030548.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858850"/>
    <dbReference type="CTD" id="51085"/>
    <dbReference type="GeneTree" id="ENSGT00940000159210"/>
    <dbReference type="OrthoDB" id="6022628at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901797">
        <property type="term" value="P:negative regulation of signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045723">
        <property type="term" value="P:positive regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045821">
        <property type="term" value="P:positive regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035774">
        <property type="term" value="P:positive regulation of insulin secretion involved in cellular response to glucose stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000432">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19689">
        <property type="entry name" value="bHLHzip_MLXIPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21771">
        <property type="entry name" value="NES2-NLS_ChREBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000028">
        <property type="entry name" value="MLX interacting protein like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF14">
        <property type="entry name" value="CARBOHYDRATE-RESPONSIVE ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="654"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="490"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="705"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="366"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018653.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="857" mass="93645" checksum="B058BC99B775E69B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EVK8</accession>
    <name>A0A8B7EVK8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TBC1 domain family member 24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TBC1D24</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ARF6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Presynapse</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020802">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599321.1">
        <property type="nucleotide sequence ID" value="XM_012743867.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599322.1">
        <property type="nucleotide sequence ID" value="XM_012743868.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EVK8"/>
    <dbReference type="Ensembl" id="ENSMICT00000048482.2">
        <property type="protein sequence ID" value="ENSMICP00000034495.2"/>
        <property type="gene ID" value="ENSMICG00000017095.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000063484.1">
        <property type="protein sequence ID" value="ENSMICP00000043177.1"/>
        <property type="gene ID" value="ENSMICG00000017095.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859755"/>
    <dbReference type="CTD" id="57465"/>
    <dbReference type="GeneTree" id="ENSGT00410000025739"/>
    <dbReference type="OrthoDB" id="10065050at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061564">
        <property type="term" value="P:axon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900408">
        <property type="term" value="P:negative regulation of cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000032">
        <property type="entry name" value="TBC1 domain family member 24 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF122">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN SKYWALKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="TLDc" evidence="16">
        <location>
            <begin position="343"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034495.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="562" mass="63268" checksum="D7E8BFFF70F654A9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EW65</accession>
    <name>A0A8B7EW65_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription termination factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TTF1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599550.1">
        <property type="nucleotide sequence ID" value="XM_012744096.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599551.1">
        <property type="nucleotide sequence ID" value="XM_012744097.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EW65"/>
    <dbReference type="Ensembl" id="ENSMICT00000063877.1">
        <property type="protein sequence ID" value="ENSMICP00000049107.1"/>
        <property type="gene ID" value="ENSMICG00000044842.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105859867"/>
    <dbReference type="KEGG" id="mmur:105859867"/>
    <dbReference type="CTD" id="7270"/>
    <dbReference type="GeneTree" id="ENSGT00940000159729"/>
    <dbReference type="OrthoDB" id="5812619at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription termination factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053078">
        <property type="entry name" value="TTF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46760">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="600"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="822" mass="94224" checksum="EE73CC4067BD6563" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2A3</accession>
    <name>A0A8B7F2A3_MICMU</name>
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        <submittedName>
            <fullName evidence="15">Solute carrier family 7 member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLC7A1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginine(in) = L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:32143"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysine(in) = L-lysine(out)</text>
            <dbReference type="Rhea" id="RHEA:70935"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-ornithine(in) = L-ornithine(out)</text>
            <dbReference type="Rhea" id="RHEA:71199"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017808">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017809">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F2A3"/>
    <dbReference type="Ensembl" id="ENSMICT00000016303.3">
        <property type="protein sequence ID" value="ENSMICP00000014860.1"/>
        <property type="gene ID" value="ENSMICG00000016312.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069677.1">
        <property type="protein sequence ID" value="ENSMICP00000041996.1"/>
        <property type="gene ID" value="ENSMICG00000016312.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861182"/>
    <dbReference type="KEGG" id="mmur:105861182"/>
    <dbReference type="CTD" id="6541"/>
    <dbReference type="GeneTree" id="ENSGT00940000155349"/>
    <dbReference type="OMA" id="TLGWPHL"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097638">
        <property type="term" value="P:L-arginine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903810">
        <property type="term" value="P:L-histidine import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015819">
        <property type="term" value="P:lysine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042102">
        <property type="term" value="P:positive regulation of T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000024">
        <property type="entry name" value="High affinity cationic amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000009">
        <property type="entry name" value="Low affinity cationic amino acid transporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004755">
        <property type="entry name" value="Cat_AA_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00906">
        <property type="entry name" value="2A0303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF28">
        <property type="entry name" value="HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="166"/>
            <end position="183"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="210"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="273"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="405"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="411"/>
            <end position="430"/>
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    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="494"/>
            <end position="515"/>
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        <location>
            <begin position="527"/>
            <end position="548"/>
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        <location>
            <begin position="560"/>
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            <begin position="585"/>
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            <begin position="558"/>
            <end position="608"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034422"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034423"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034450"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041996.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="629" mass="67659" checksum="1851E70C5D7101EE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6N9</accession>
    <name>A0A8B7F6N9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 624</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF624</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020655">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012747993.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603449.1">
        <property type="nucleotide sequence ID" value="XM_012747995.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6N9"/>
    <dbReference type="Ensembl" id="ENSMICT00000036266.2">
        <property type="protein sequence ID" value="ENSMICP00000023108.1"/>
        <property type="gene ID" value="ENSMICG00000012812.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065215.1">
        <property type="protein sequence ID" value="ENSMICP00000049906.1"/>
        <property type="gene ID" value="ENSMICG00000012812.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862013"/>
    <dbReference type="CTD" id="57547"/>
    <dbReference type="GeneTree" id="ENSGT00940000163207"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000622">
        <property type="entry name" value="zinc finger protein 26 isoform X3"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 286A isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 540"/>
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        <property type="entry name" value="zinc finger protein 624 isoform X1"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="21"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF178">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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    </dbReference>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="20"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
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        </location>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="612"/>
            <end position="639"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="668"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="696"/>
            <end position="723"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="724"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="752"/>
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        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="836"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="865" mass="99477" checksum="56F1E141AB9DEFAA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FD70</accession>
    <name>A0A8B7FD70_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="7">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WASF2</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001806">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606071.1">
        <property type="nucleotide sequence ID" value="XM_012750617.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606072.1">
        <property type="nucleotide sequence ID" value="XM_012750618.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606073.1">
        <property type="nucleotide sequence ID" value="XM_012750619.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606074.1">
        <property type="nucleotide sequence ID" value="XM_012750620.3"/>
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    <dbReference type="RefSeq" id="XP_012606075.1">
        <property type="nucleotide sequence ID" value="XM_012750621.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606076.1">
        <property type="nucleotide sequence ID" value="XM_012750622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FD70"/>
    <dbReference type="Ensembl" id="ENSMICT00000063875.1">
        <property type="protein sequence ID" value="ENSMICP00000044153.1"/>
        <property type="gene ID" value="ENSMICG00000015799.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863499"/>
    <dbReference type="KEGG" id="mmur:105863499"/>
    <dbReference type="CTD" id="10163"/>
    <dbReference type="GeneTree" id="ENSGT00950000182962"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:early endosome"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:ruffle"/>
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        <property type="term" value="C:SCAR complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:Arp2/3 complex binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SH3 domain binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:angiogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:endocytosis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:neuron migration"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000012">
        <property type="entry name" value="Wiskott-Aldrich syndrome protein family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF6">
        <property type="entry name" value="ACTIN-BINDING PROTEIN WASF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="9">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="298"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="497" mass="54050" checksum="FB3FD2C32199BF57" modified="2022-01-19" version="1">MPLVTRNIEPRHLCRQTLPSVRSELECVTNISLANVIRQLGSLSKYAEDIFGEIFTQANTFASRVSSLAKRVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGPSGYPPTLVYQNGSIGSVENVDAGSYPPPPQSDSASSPSPVFSEDNLPPPPAEFSYPADNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPMIGVPPPPPPIGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPAGGAPPPPPPPPPPGPPPPPFSGMDGQPGIPPPLSDATKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQQEQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FJZ2</accession>
    <name>A0A8B7FJZ2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Solute carrier family 39 member 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLC39A5</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009854">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608934.1">
        <property type="nucleotide sequence ID" value="XM_012753480.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608937.1">
        <property type="nucleotide sequence ID" value="XM_012753483.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608944.1">
        <property type="nucleotide sequence ID" value="XM_012753490.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608953.1">
        <property type="nucleotide sequence ID" value="XM_012753499.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608961.1">
        <property type="nucleotide sequence ID" value="XM_012753507.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608967.1">
        <property type="nucleotide sequence ID" value="XM_012753513.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608973.1">
        <property type="nucleotide sequence ID" value="XM_012753519.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608984.1">
        <property type="nucleotide sequence ID" value="XM_012753530.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608990.1">
        <property type="nucleotide sequence ID" value="XM_012753536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FJZ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000014490.3">
        <property type="protein sequence ID" value="ENSMICP00000013207.1"/>
        <property type="gene ID" value="ENSMICG00000014494.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865121"/>
    <dbReference type="KEGG" id="mmur:105865121"/>
    <dbReference type="CTD" id="283375"/>
    <dbReference type="GeneTree" id="ENSGT00940000161155"/>
    <dbReference type="OMA" id="GANITWM"/>
    <dbReference type="OrthoDB" id="200954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140410">
        <property type="term" value="F:monoatomic cation:bicarbonate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034224">
        <property type="term" value="P:cellular response to zinc ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001654">
        <property type="term" value="P:eye development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050799">
        <property type="entry name" value="ZIP_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12191:SF17">
        <property type="entry name" value="ZINC TRANSPORTER ZIP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0864">Zinc transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133611" evidence="10">
        <location>
            <begin position="25"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="325"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="539" mass="56502" checksum="F5228FF66F8A5E97" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FK29</accession>
    <name>A0A8B7FK29_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Sp9 transcription factor</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="17">Transcription factor Sp9 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15 17" type="primary">SP9</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="17">Liver</tissue>
        </source>
    </reference>
    <reference evidence="15" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Sp1 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011068">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608893.1">
        <property type="nucleotide sequence ID" value="XM_012753439.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FK29"/>
    <dbReference type="Ensembl" id="ENSMICT00000039444.2">
        <property type="protein sequence ID" value="ENSMICP00000026245.1"/>
        <property type="gene ID" value="ENSMICG00000031506.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105865086"/>
    <dbReference type="KEGG" id="mmur:105865086"/>
    <dbReference type="CTD" id="100131390"/>
    <dbReference type="GeneTree" id="ENSGT00940000162304"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22549">
        <property type="entry name" value="SP9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000077">
        <property type="entry name" value="Sp8 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000014">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000026">
        <property type="entry name" value="Transcription factor Sp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR SP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="332"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="409"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FP14</accession>
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        <submittedName>
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        <name evidence="9" type="primary">MTCL2</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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            <begin position="1057"/>
            <end position="1109"/>
        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="Pfam" id="PF14818"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FQ86</accession>
    <name>A0A8B7FQ86_MICMU</name>
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        <submittedName>
            <fullName evidence="13 15">Zinc finger protein 503</fullName>
        </submittedName>
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    <gene>
        <name evidence="13 15" type="primary">ZNF503</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="13" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="15">Liver</tissue>
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    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Elbow/Noc family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012755574.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000009922.2"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:nucleus"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070315">
        <property type="term" value="P:G1 to G0 transition involved in cell differentiation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="P:neural precursor cell proliferation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 503"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051520">
        <property type="entry name" value="Elbow/Noc_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022129">
        <property type="entry name" value="Tscrpt_rep_NocA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522:SF3">
        <property type="entry name" value="ZINC FINGER PROTEIN 503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12522">
        <property type="entry name" value="ZINC-FINGER PROTEIN NOLZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12402">
        <property type="entry name" value="nlz1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="115"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="220"/>
            <end position="233"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="271"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="302"/>
            <end position="324"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010144"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009922.2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="RefSeq" id="XP_012611028.1"/>
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    </evidence>
    <sequence length="640" mass="62222" checksum="DA2C3A25A5D68F5D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FTS9</accession>
    <name>A0A8B7FTS9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Solute carrier family 25 member 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SLC25A13</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)</text>
            <dbReference type="Rhea" id="RHEA:70975"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>3-sulfino-L-alanine(out) + L-glutamate(in) + H(+)(in) = 3-sulfino-L-alanine(in) + L-glutamate(out) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:70967"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-aspartate(in) + L-glutamate(out) + H(+)(out) = L-aspartate(out) + L-glutamate(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70783"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612573.1">
        <property type="nucleotide sequence ID" value="XM_012757119.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FTS9"/>
    <dbReference type="Ensembl" id="ENSMICT00000036105.2">
        <property type="protein sequence ID" value="ENSMICP00000025493.1"/>
        <property type="gene ID" value="ENSMICG00000008911.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867266"/>
    <dbReference type="CTD" id="10165"/>
    <dbReference type="GeneTree" id="ENSGT00940000159344"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000514">
        <property type="term" value="F:3-sulfino-L-alanine: proton, glutamate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000515">
        <property type="term" value="F:aspartate:glutamate, proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051592">
        <property type="term" value="P:response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000064">
        <property type="entry name" value="calcium-binding mitochondrial carrier protein Aralar1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000529">
        <property type="entry name" value="Solute carrier family 25 member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF12">
        <property type="entry name" value="ELECTROGENIC ASPARTATE_GLUTAMATE ANTIPORTER SLC25A13, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="21">
        <location>
            <begin position="326"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="21">
        <location>
            <begin position="426"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="21">
        <location>
            <begin position="518"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="675" mass="74250" checksum="1606E548DB357FE5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G2C4</accession>
    <name>A0A8B7G2C4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Distal membrane-arm assembly complex protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP synthase subunit s-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">DMAC2</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with incompletely assembled mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP synthase subunit s family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026926">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G2C4"/>
    <dbReference type="Ensembl" id="ENSMICT00000045436.2">
        <property type="protein sequence ID" value="ENSMICP00000016346.1"/>
        <property type="gene ID" value="ENSMICG00000033752.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869123"/>
    <dbReference type="KEGG" id="mmur:105869123"/>
    <dbReference type="CTD" id="55101"/>
    <dbReference type="GeneTree" id="ENSGT00940000160500"/>
    <dbReference type="OrthoDB" id="5859291at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000168">
        <property type="entry name" value="Distal membrane arm assembly complex 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF186">
        <property type="entry name" value="DISTAL MEMBRANE-ARM ASSEMBLY COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00062608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="255" mass="28570" checksum="5BD42CFEEB24ABC8" modified="2022-01-19" version="1">MAAPRTSLRLVAAIWSTRGIHGRGGAATPEGSQKKGKTLLQFLSDRFYDVEFLREYFLQRQMLKVHQKNRSFTHMVEQYGPYIVGACFILDQGGMVKFQNNDWIGPKERGRFALEFSKFQEVSVEAVDASGCAINYEGLDNLLLLRNLQSLSLRHCPHVDDWCLSRLYPLASSLQELSLAGCPHISERGLACLHHLPNLRKLDISDLPAVSNPGLTQILMEEMLPNCEILGASWAQGLNVEPEEQPQDKASPVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G3Z1</accession>
    <name>A0A8B7G3Z1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Vasodilator-stimulated phosphoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">VASP</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Homotetramer. Interacts with PFN1, PFN2, LPP, ACTN1 and ACTG1. Interacts, via the EVH1 domain, with the Pro-rich regions of ZYX. This interaction is important for targeting to focal adhesions and the formation of actin-rich structures at the apical surface of cells. Interacts, via the EVH1 domain, with the Pro-rich domain of Listeria monocytogenes actA. Interacts with APBB1IP. Interacts, via the Pro-rich domain, with the C-terminal SH3 domain of DNMBP. Interacts weakly with MEFV.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cell projection</location>
            <location evidence="19">Filopodium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Lamellipodium membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 23">Cytoplasm</location>
            <location evidence="2 23">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 23">Belongs to the Ena/VASP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616868.1">
        <property type="nucleotide sequence ID" value="XM_012761414.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G3Z1"/>
    <dbReference type="Ensembl" id="ENSMICT00000058326.1">
        <property type="protein sequence ID" value="ENSMICP00000045596.1"/>
        <property type="gene ID" value="ENSMICG00000044750.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105869534"/>
    <dbReference type="KEGG" id="mmur:105869534"/>
    <dbReference type="CTD" id="7408"/>
    <dbReference type="GeneTree" id="ENSGT00940000156765"/>
    <dbReference type="OMA" id="TSEAHPC"/>
    <dbReference type="OrthoDB" id="31170at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031258">
        <property type="term" value="C:lamellipodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005522">
        <property type="term" value="F:profilin binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:actin polymerization or depolymerization"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:axon guidance"/>
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        <property type="term" value="P:neural tube closure"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030838">
        <property type="term" value="P:positive regulation of actin filament polymerization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051289">
        <property type="term" value="P:protein homotetramerization"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01207">
        <property type="entry name" value="EVH1_Ena_VASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WH2_hVASP-like"/>
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    </dbReference>
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        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
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    </dbReference>
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        <property type="entry name" value="vasodilator-stimulated phosphoprotein isoform X2"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
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        <property type="entry name" value="VASP/EVL"/>
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    <dbReference type="InterPro" id="IPR038023">
        <property type="entry name" value="VASP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014885">
        <property type="entry name" value="VASP_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202">
        <property type="entry name" value="SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11202:SF12">
        <property type="entry name" value="VASODILATOR-STIMULATED PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08776">
        <property type="entry name" value="VASP_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038010">
        <property type="entry name" value="Vasodilator_Phospo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118370">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein, VASP, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16 23" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 23" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17 23" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="6" id="KW-0796">Tight junction</keyword>
    <feature type="domain" description="WH1" evidence="25">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="111"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="237"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00046311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00059051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00074299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRNR" id="PIRNR038010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="378" mass="39727" checksum="F908296689E0B50D" modified="2022-01-19" version="1">MSETAVCSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYHQATPTFHQWRDARQVWGLNFGSKEDAAQFANGMASALEALEGGGPPPPAAPPTWSVQNGPSPEEVEQHRRQQSGQPELERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVSAAGHGAGGGPPPAPPLPAAQGPSGGGAGAPGLAAAIAGAKLRKVSKQEEALGGPVAPKAESSRSTGGGLMEEMNAMLARRRKATQVGEKPPKDDSANQEEPEARVPAHSESVRRPWEKNSTTLPRMKSSSALTSEAHPCTPSSSDESDLERVKQELLEEVRKELQKVKEEIIEAFVQELRKRGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G4I3</accession>
    <name>A0A8B7G4I3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">39S ribosomal protein L44, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">MRPL44</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616519.1">
        <property type="nucleotide sequence ID" value="XM_012761065.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G4I3"/>
    <dbReference type="Ensembl" id="ENSMICT00000042278.2">
        <property type="protein sequence ID" value="ENSMICP00000022818.1"/>
        <property type="gene ID" value="ENSMICG00000033078.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869354"/>
    <dbReference type="KEGG" id="mmur:105869354"/>
    <dbReference type="CTD" id="65080"/>
    <dbReference type="GeneTree" id="ENSGT00390000016956"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19874">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000010">
        <property type="entry name" value="39S ribosomal protein L44, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000037">
        <property type="entry name" value="39S ribosomal protein L44, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055189">
        <property type="entry name" value="RM44_endonuclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22935">
        <property type="entry name" value="RM44_endonuclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DRBM" evidence="15">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00083955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="331" mass="37662" checksum="7AFEA366B5018976" modified="2022-01-19" version="1">MASRLVSLLQQAPHCLLAPKVPTLVPSVRGVKDFRAAFRFQKELERRRLLRCPPPPVRRSEKPNWDYHAEIQAFGPRLQETFSLDLLKTAFVNSCYIKSEEAKRQKLGIEKEALLLNLKCNQELSEQGKSFSQTCLTKFLEDEYPDLPTEGIKGLVDFLTSEEIVCHVARNLAVEQLTLSAEFPVPLPVLQRTFFAVIGALLQSSGPERAALFIRDFLITQMTGKELFEMWKIINPMGLLLEELKKRNISTPEPRLIRQSGSTTVLPLYFVGLYCDKKLIAEGPGETILVAEEEAARVALRKLYGFTENRRPWDYSKPKEDLRAQKTITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G4U1</accession>
    <name>A0A8B7G4U1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA excision repair protein ERCC-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ERCC1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026742">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026743">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616883.1">
        <property type="nucleotide sequence ID" value="XM_012761429.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616884.1">
        <property type="nucleotide sequence ID" value="XM_012761430.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616885.1">
        <property type="nucleotide sequence ID" value="XM_012761431.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616886.1">
        <property type="nucleotide sequence ID" value="XM_012761432.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616887.1">
        <property type="nucleotide sequence ID" value="XM_012761433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G4U1"/>
    <dbReference type="Ensembl" id="ENSMICT00000040272.2">
        <property type="protein sequence ID" value="ENSMICP00000028795.1"/>
        <property type="gene ID" value="ENSMICG00000001806.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869537"/>
    <dbReference type="KEGG" id="mmur:105869537"/>
    <dbReference type="CTD" id="2067"/>
    <dbReference type="GeneTree" id="ENSGT00390000011275"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000017">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="10">
        <location>
            <begin position="100"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="298" mass="32789" checksum="2BDE8E3150C564ED" modified="2022-01-19" version="1">MDPGKDEEGVPQPAGPPTRKKFVIPLDEDEVPPAGAKPLFKSTRILPPVDTSAQATPQTYAEYAISRPPGGAGVTCPKGPEPLAGETLNQALKPGTKSNSIIVSPRQRGNPVLKFVRNVPWEFGDVIPDYVLGQSTCALFLSLRYHNLHPDYIHERLQGLGKNFALRVLLIQVDVKDPQQALKELAKMCILADCTLVLAWSPEEAGRYLETYKAYEQKPADLLLEKLEQDFVSRVTECLTTVKSVNKTDSQTLLATFGSLEQLIAASREDLALCPGLGPQKARRLFEVLHEPFLKVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G877</accession>
    <name>A0A8B7G877_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Nucleolar RNA helicase 2</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">DEAD box protein 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Gu-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Nucleolar RNA helicase Gu</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Nucleolar RNA helicase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">RH II/Gu</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="primary">DDX21</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03018921">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618119.1">
        <property type="nucleotide sequence ID" value="XM_012762665.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G877"/>
    <dbReference type="Ensembl" id="ENSMICT00000015110.3">
        <property type="protein sequence ID" value="ENSMICP00000013780.2"/>
        <property type="gene ID" value="ENSMICG00000015112.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870218"/>
    <dbReference type="KEGG" id="mmur:105870218"/>
    <dbReference type="CTD" id="9188"/>
    <dbReference type="GeneTree" id="ENSGT00940000155043"/>
    <dbReference type="OrthoDB" id="4255at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17944">
        <property type="entry name" value="DEADc_DDX21_DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12936">
        <property type="entry name" value="GUCT_RHII_Gualpha_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000666">
        <property type="entry name" value="ATP-dependent RNA helicase DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2280:FF:000002">
        <property type="entry name" value="Nucleolar RNA helicase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001168">
        <property type="entry name" value="nucleolar RNA helicase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059027">
        <property type="entry name" value="DD_DDX21-DDX50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF19">
        <property type="entry name" value="NUCLEOLAR RNA HELICASE 2-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26142">
        <property type="entry name" value="DD_DDX21-DDX50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0007">Acetylation</keyword>
    <keyword evidence="19" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0391">Immunity</keyword>
    <keyword evidence="10" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="21" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="31">
        <location>
            <begin position="217"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="32">
        <location>
            <begin position="429"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="708"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="30">
        <location>
            <begin position="167"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="30">
        <location>
            <begin position="726"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="30">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00074346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00075447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00075530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00075569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00075679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00078637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013780.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="783" mass="86983" checksum="CB244A34974E643C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G9C2</accession>
    <name>A0A8B7G9C2_MICMU</name>
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        <recommendedName>
            <fullName evidence="14">Mitogen-activated protein kinase kinase kinase 12</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MAP3K12</name>
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    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">May be an activator of the JNK/SAPK pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03009578">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619067.1">
        <property type="nucleotide sequence ID" value="XM_012763613.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619084.1">
        <property type="nucleotide sequence ID" value="XM_012763630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G9C2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011662.3">
        <property type="protein sequence ID" value="ENSMICP00000010613.2"/>
        <property type="gene ID" value="ENSMICG00000011662.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105870789"/>
    <dbReference type="CTD" id="7786"/>
    <dbReference type="GeneTree" id="ENSGT00940000159006"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007254">
        <property type="term" value="P:JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14059">
        <property type="entry name" value="STKc_MAP3K12_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000087">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000095">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017419">
        <property type="entry name" value="MAP3K12_MAP3K13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027257">
        <property type="entry name" value="MAPKKK12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF17">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500741">
        <property type="entry name" value="MAPKKK12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038165">
        <property type="entry name" value="MAPKKK12_MAPKKK13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="125"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="524"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="611"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="419"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="131"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR038165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR038165-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR038165-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010613.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="858" mass="93359" checksum="ECCD08CB20F1F291" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GFR3</accession>
    <name>A0A8B7GFR3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sperm microtubule associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">SPMAP1</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020128">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621395.1">
        <property type="nucleotide sequence ID" value="XM_012765941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GFR3"/>
    <dbReference type="Ensembl" id="ENSMICT00000047792.2">
        <property type="protein sequence ID" value="ENSMICP00000030226.1"/>
        <property type="gene ID" value="ENSMICG00000027799.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105872127"/>
    <dbReference type="KEGG" id="mmur:105872127"/>
    <dbReference type="CTD" id="388381"/>
    <dbReference type="GeneTree" id="ENSGT00390000004450"/>
    <dbReference type="OrthoDB" id="9935043at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028027">
        <property type="entry name" value="SPMAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221">
        <property type="entry name" value="HYPOTHETICAL PROTEIN LOC691189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34221:SF2">
        <property type="entry name" value="RIKEN CDNA 1700001P01 GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15075">
        <property type="entry name" value="SPMAP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="154" mass="17874" checksum="15857144A4D02BB0" modified="2022-01-19" version="1">MAYLCHCPLRLEKGFILDGVAVSTMARTYELTRPKLWSAIPPYNAQQDYHTRRYFQSHVVPPVLRKTLQDRCGTGRDGWVVDYYHIFGQGQRYLNRRNWSGAGHSAQQVTGHDHYNADLRPINGFNGRFGYRRNTPALRQRPSVFGEVTQFPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GFV9</accession>
    <name>A0A8B7GFV9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Aminopeptidase</fullName>
            <ecNumber evidence="24">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">ENPEP</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.</text>
            <dbReference type="EC" id="3.4.11.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22 24">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22 24">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 24">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="24"/>
    <dbReference type="EMBL" id="ABDC03030211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03030212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621645.2">
        <property type="nucleotide sequence ID" value="XM_012766191.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GFV9"/>
    <dbReference type="Ensembl" id="ENSMICT00000070894.1">
        <property type="protein sequence ID" value="ENSMICP00000045444.1"/>
        <property type="gene ID" value="ENSMICG00000042642.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105872302"/>
    <dbReference type="CTD" id="2028"/>
    <dbReference type="GeneTree" id="ENSGT00940000156946"/>
    <dbReference type="OrthoDB" id="510539at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004230">
        <property type="term" value="F:glutamyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002003">
        <property type="term" value="P:angiotensin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032835">
        <property type="term" value="P:glomerulus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000006">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000003">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000016">
        <property type="entry name" value="Glutamyl aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF276">
        <property type="entry name" value="GLUTAMYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 24" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="13" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 24" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 22 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 24" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 24" id="KW-0645">Protease</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12 22 24" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="28">
        <location>
            <begin position="97"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="26">
        <location>
            <begin position="319"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="27">
        <location>
            <begin position="614"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="20">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="355"/>
            <end position="359"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="23">
        <location>
            <position position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="955" mass="108273" checksum="4CF7A3E6E04ECA8C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GHS4</accession>
    <name>A0A8B7GHS4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phosphoinositide 3-kinase regulatory subunit 4</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="primary">PIK3R4</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="22">Component of the PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex the core of which is composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 associating with additional regulatory/auxiliary subunits to form alternative complex forms. Alternative complex forms containing a fourth regulatory subunit in a mutually exclusive manner are PI3K complex I (PI3KC3-C1) containing ATG14, and PI3K complex II (PI3KC3-C2) containing UVRAG. PI3KC3-C1 displays a V-shaped architecture with PIK3R4 serving as a bridge between PIK3C3 and the ATG14:BECN1 subcomplex. Both, PI3KC3-C1 and PI3KC3-C2, can associate with further regulatory subunits, such as RUBCN, SH3GLB1/Bif-1, AMBRA1 and NRBF2. PI3KC3-C1 probably associates with PIK3CB. Interacts with RAB7A in the presence of PIK3C3/VPS34. Interacts with NRBF2. Interacts with ARMC3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03000086">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622374.2">
        <property type="nucleotide sequence ID" value="XM_012766920.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143760.1">
        <property type="nucleotide sequence ID" value="XM_020288171.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143781.1">
        <property type="nucleotide sequence ID" value="XM_020288192.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143793.1">
        <property type="nucleotide sequence ID" value="XM_020288204.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143807.1">
        <property type="nucleotide sequence ID" value="XM_020288218.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143847.1">
        <property type="nucleotide sequence ID" value="XM_020288258.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000072635.1">
        <property type="protein sequence ID" value="ENSMICP00000051431.1"/>
        <property type="gene ID" value="ENSMICG00000049166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872695"/>
    <dbReference type="KEGG" id="mmur:105872695"/>
    <dbReference type="CTD" id="30849"/>
    <dbReference type="GeneTree" id="ENSGT00390000016225"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036092">
        <property type="term" value="P:phosphatidylinositol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032801">
        <property type="term" value="P:receptor catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032465">
        <property type="term" value="P:regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016241">
        <property type="term" value="P:regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000305">
        <property type="entry name" value="phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000100">
        <property type="entry name" value="phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000154">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000396">
        <property type="entry name" value="phosphoinositide 3-kinase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0519">Myristate</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 25" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="24">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="25">
        <location>
            <begin position="989"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="25">
        <location>
            <begin position="1325"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1307"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1315"/>
            <end position="1326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00053507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00062774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00073019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1358" mass="153203" checksum="6E1D6AE1B7DAE55A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GJ75</accession>
    <name>A0A8B7GJ75_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Exopolyphosphatase PRUNE1</fullName>
            <ecNumber evidence="6">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PRUNE1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Homooligomer. Able to homodimerize via its C-terminal domain. Interacts with NME1. Interacts with GSK3; at focal adhesion complexes where paxillin and vinculin are colocalized. Interacts with alpha and beta tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Focal adhesion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPase class C family. Prune subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03002979">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002980">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622954.1">
        <property type="nucleotide sequence ID" value="XM_012767500.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GJ75"/>
    <dbReference type="Ensembl" id="ENSMICT00000071073.1">
        <property type="protein sequence ID" value="ENSMICP00000047954.1"/>
        <property type="gene ID" value="ENSMICG00000000451.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872997"/>
    <dbReference type="KEGG" id="mmur:105872997"/>
    <dbReference type="CTD" id="58497"/>
    <dbReference type="GeneTree" id="ENSGT00450000040262"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005925">
        <property type="term" value="C:focal adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031113">
        <property type="term" value="P:regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050767">
        <property type="term" value="P:regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.310.20:FF:000003">
        <property type="entry name" value="Prune exopolyphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1640.10:FF:000004">
        <property type="entry name" value="Prune exopolyphosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF47">
        <property type="entry name" value="EXOPOLYPHOSPHATASE PRUNE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="20">
        <location>
            <begin position="215"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00073821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="453" mass="50149" checksum="CCD6C91CF805C1EA" modified="2022-01-19" version="1">MEDYLQGCRAALQESRPLHVVLGNEACDLDSMVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDNIFFLQKVNIPETILIFRDEIDLHALHQAGQLTLILVDHHVLPKSDAALEEAVAEVLDHRPIEQKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATLKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGIKVAISAIYMDLEAFLQRSDLLADLHAFCQAHSYDVLVAMTIFFNTQNEPVRQLAIFCPHVALRMTICGVLESSHSPSLKLTPAPSTHPNLQAYLQGNTQVSRKKLLPLLQEALSVYFDSMKIPSGQSETVVVSKEQVDKELDRASNSLIPGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GLT5</accession>
    <name>A0A8B7GLT5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TUBB2A</name>
        <name evidence="16" type="synonym">LOC105873482</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GLT5"/>
    <dbReference type="SMR" id="A0A8B7GLT5"/>
    <dbReference type="Ensembl" id="ENSMICT00000060745.1">
        <property type="protein sequence ID" value="ENSMICP00000049344.1"/>
        <property type="gene ID" value="ENSMICG00000000129.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873482"/>
    <dbReference type="GeneTree" id="ENSGT00940000154150"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045171">
        <property type="term" value="C:intercellular bridge"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000006">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="445" mass="49953" checksum="4DC3956EFF880746" modified="2022-01-19" version="1">MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GVR7</accession>
    <name>A0A8B7GVR7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bublin coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BBLN</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627526.1">
        <property type="nucleotide sequence ID" value="XM_012772072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GVR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000058264.1">
        <property type="protein sequence ID" value="ENSMICP00000040796.1"/>
        <property type="gene ID" value="ENSMICG00000046320.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105875244"/>
    <dbReference type="KEGG" id="mmur:105875244"/>
    <dbReference type="CTD" id="79095"/>
    <dbReference type="GeneTree" id="ENSGT00390000001761"/>
    <dbReference type="OMA" id="INLMLDQ"/>
    <dbReference type="OrthoDB" id="10050612at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005882">
        <property type="term" value="C:intermediate filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120219">
        <property type="term" value="C:subapical part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045453">
        <property type="term" value="P:bone resorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045110">
        <property type="term" value="P:intermediate filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072674">
        <property type="term" value="P:multinuclear osteoclast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005374">
        <property type="entry name" value="BBLN_eukaryota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34344:SF1">
        <property type="entry name" value="BUBLIN COILED-COIL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34344">
        <property type="entry name" value="UPF0184 PROTEIN C9ORF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03670">
        <property type="entry name" value="UPF0184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="83" mass="9169" checksum="E8DBDA7877DDBCD7" modified="2022-01-19" version="1">MSGPNGDLNMPVEAGAEGEDDGFGEAEYAAINSMLDQINSCLDHLEEKNDHLHARLQELLESNRQTRLEFQQQLEEAPSDASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GWD1</accession>
    <name>A0A8B7GWD1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA pseudouridine(38/39) synthase</fullName>
            <ecNumber evidence="8">5.4.99.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA pseudouridine synthase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA pseudouridylate synthase 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA-uridine isomerase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PUS3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine(38/39) in tRNA = pseudouridine(38/39) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42564"/>
            <dbReference type="Rhea" id="RHEA-COMP:10117"/>
            <dbReference type="Rhea" id="RHEA-COMP:10118"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.45"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.45" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03007219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627823.1">
        <property type="nucleotide sequence ID" value="XM_012772369.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627824.1">
        <property type="nucleotide sequence ID" value="XM_012772370.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GWD1"/>
    <dbReference type="SMR" id="A0A8B7GWD1"/>
    <dbReference type="Ensembl" id="ENSMICT00000033955.2">
        <property type="protein sequence ID" value="ENSMICP00000022006.2"/>
        <property type="gene ID" value="ENSMICG00000032941.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065606.1">
        <property type="protein sequence ID" value="ENSMICP00000046032.1"/>
        <property type="gene ID" value="ENSMICG00000032941.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875369"/>
    <dbReference type="KEGG" id="mmur:105875369"/>
    <dbReference type="CTD" id="83480"/>
    <dbReference type="GeneTree" id="ENSGT00950000183160"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160154">
        <property type="term" value="F:tRNA pseudouridine(38/39) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02569">
        <property type="entry name" value="PseudoU_synth_ScPus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.580:FF:000007">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000005">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041707">
        <property type="entry name" value="Pus3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="14">
        <location>
            <begin position="211"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00066567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00079075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00080861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="480" mass="55809" checksum="DCAD9259DAEEBBFB" modified="2022-01-19" version="1">MAENYRDGNQTKRLLKRVQELEKEVQRLKKEQANTKDSNVRENSSGGGKAKRAFDFRAHGQRHIALKIAYLGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKGVSAFGQVISLDLRSQFPRGRDSEDFYLKDEASDAAKEIRYTHILNRVLPTDIRILAWAPVEPSFSARFSCLERTYRYFFPLADLDIETMNYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVKLVGQSLGEERWQEPFQLCQFEVTGQAFLYHQVRCMMAILFLIGQRMEKPEIIDELLNIQKNPQKPQYSMAVEFPLVLYDCKFENIEWIYDREVQEFNVTHLQQLWANYAIKTHMLYSMLQGLDSVAVPCGTGPKMDGMIEWRNVKPSVIKQTSAFVEGVKMRTYKPLMDRPKCQGLESRIQHFVHRGRIEHPPLFHEEEIKAKRDCNDTMEEENTILETPTKRVCVDTKIKNIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GYJ3</accession>
    <name>A0A8B7GYJ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 170A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TMEM170A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024138">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627971.1">
        <property type="nucleotide sequence ID" value="XM_012772517.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GYJ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000063968.1">
        <property type="protein sequence ID" value="ENSMICP00000046483.1"/>
        <property type="gene ID" value="ENSMICG00000043281.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105875453"/>
    <dbReference type="KEGG" id="mmur:105875453"/>
    <dbReference type="CTD" id="124491"/>
    <dbReference type="GeneTree" id="ENSGT00940000159189"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051292">
        <property type="term" value="P:nuclear pore complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 170A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="144" mass="15280" checksum="7F4BA688865042ED" modified="2022-01-19" version="1">MEREGSGGSGSSAGLLQQILSLKLVPRVGNGTLCPNSTSLCSFPEMWYGVFLWALVSSLFFHVPAGLLALFTLRHHKYGRFMSVSILLMGIVGPITAGILTSAAIAGVYRAAGKEMIPFEALTLGTGQTFCVVVVSFLRILATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H324</accession>
    <name>A0A8B7H324_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">b(0,+)-type amino acid transporter 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Glycoprotein-associated amino acid transporter b0,+AT1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Solute carrier family 7 member 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SLC7A9</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-phenylalanine(out) + L-arginine(in) = L-phenylalanine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71067"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:71068"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71071"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:71072"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71075"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:71076"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:71064"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71059"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:71060"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysine(out) + L-arginine(in) = L-lysine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:70827"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:70828"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630631.1">
        <property type="nucleotide sequence ID" value="XM_012775177.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H324"/>
    <dbReference type="Ensembl" id="ENSMICT00000063274.1">
        <property type="protein sequence ID" value="ENSMICP00000047336.1"/>
        <property type="gene ID" value="ENSMICG00000046921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105876988"/>
    <dbReference type="KEGG" id="mmur:105876988"/>
    <dbReference type="CTD" id="11136"/>
    <dbReference type="GeneTree" id="ENSGT00940000156370"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180009">
        <property type="term" value="F:broad specificity neutral L-amino acid:basic L-amino acid antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000015">
        <property type="entry name" value="B(0,+)-type amino acid transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF354">
        <property type="entry name" value="B(0,+)-TYPE AMINO ACID TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00093193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="487" mass="53041" checksum="EF2D14FB55A61D74" modified="2022-01-19" version="1">MGETSVRKRREDAKSGESSEPKTTSLQKEVGLISGISIIVGTIIGSGIFISPKSVLSNTEAVGPCLIIWAVCGVLATLGALCYAELGTMITKSGGEYPYLMEAYGPIPAYLFSWTSLIVIKPSSFAIICLTFSEYVSAPFYSGCKPPTVVVKCLGAAAILFIVIVNSLSVRLGSLVQNVFTAAKLVIVAVIIIGGFVLLAQGNTKNFENSFEGADVSVGAISLAFYNGLWAYDGWNQLNYITEELKNPYRNLPLAIVIGIPLVTVCYILMNVSYFTAMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTLGAANGSCFTAGRLIYVAGREGHMLKVLSYISVKRLTPAPAIIFHGIIAIIYIIPGDINSLVNYFSFASWLFYGLTVLGLVVMRFTRKELERPIQVPVAIPILVTCISVFLVLAPIISAPAWEYLYCVLFILSGLIFYFLFVYYKFGWAQKISKPITMHLQMLMEAVPPEEDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H802</accession>
    <name>A0A8B7H802_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Monocarboxylate transporter 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Solute carrier family 16 member 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">SLC16A13</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632681.1">
        <property type="nucleotide sequence ID" value="XM_012777227.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H802"/>
    <dbReference type="Ensembl" id="ENSMICT00000005923.3">
        <property type="protein sequence ID" value="ENSMICP00000005405.2"/>
        <property type="gene ID" value="ENSMICG00000005926.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878062"/>
    <dbReference type="KEGG" id="mmur:105878062"/>
    <dbReference type="CTD" id="201232"/>
    <dbReference type="GeneTree" id="ENSGT00940000159372"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008028">
        <property type="term" value="F:monocarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17423">
        <property type="entry name" value="MFS_MCT11_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000163">
        <property type="entry name" value="Putative monocarboxylate transporter 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048233">
        <property type="entry name" value="MFS_MCT_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF19">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0769">Symport</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="13"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005405.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="429" mass="44784" checksum="32E65BEAE3990C78" modified="2022-01-19" version="1">MASRAEPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFGEQAARVSWIASIGIAVQQFGSPVGSALSTKFGPRPVVMTGGILAALGMLLASFATSLTHLYLSIGLLSGSGWALTFAPTLACLSCYFSRHRSLATGMALTGVGLSSFAFAPLFQWLLSYYAWRGALLLVSALSLHLVACGALLRPLCLAEDATVGGPWAQLTSLLHHGPFLRYTAALTLINTGYFIPYVHLVAHLQDLGWDPLPAAFLLSVAAISDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQSPTALVALTVAYGFTSGALTPVAFSVLPELVGTGRIYCGLGLLQMVESLGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLITLPHFFSCACFSATTSRPQELVTEALATKVPLPKEGLGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H991</accession>
    <name>A0A8B7H991_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complement component C6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">C6</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Component of the membrane attack complex (MAC), composed of complement C5b, C6, C7, C8A, C8B, C8G and multiple copies of the pore-forming subunit C9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Target cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complement C6/C7/C8/C9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016472">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633233.1">
        <property type="nucleotide sequence ID" value="XM_012777779.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H991"/>
    <dbReference type="Ensembl" id="ENSMICT00000068728.1">
        <property type="protein sequence ID" value="ENSMICP00000047906.1"/>
        <property type="gene ID" value="ENSMICG00000012415.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878388"/>
    <dbReference type="CTD" id="729"/>
    <dbReference type="GeneTree" id="ENSGT00940000156814"/>
    <dbReference type="OrthoDB" id="9867095at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005579">
        <property type="term" value="C:membrane attack complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044218">
        <property type="term" value="C:other organism cell membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006958">
        <property type="term" value="P:complement activation, classical pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.30:FF:000046">
        <property type="entry name" value="Complement component C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000002">
        <property type="entry name" value="Unc-5 netrin receptor C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048828">
        <property type="entry name" value="C6_KAZAL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048831">
        <property type="entry name" value="C8A_B_C6_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003884">
        <property type="entry name" value="FacI_MAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001862">
        <property type="entry name" value="MAC_perforin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020864">
        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020863">
        <property type="entry name" value="MACPF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45742:SF4">
        <property type="entry name" value="COMPLEMENT COMPONENT C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21195">
        <property type="entry name" value="EGF_C8A_B_C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21288">
        <property type="entry name" value="Kazal_C6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00057">
        <property type="entry name" value="Ldl_recept_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00764">
        <property type="entry name" value="COMPLEMENTC9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00057">
        <property type="entry name" value="FIMAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00192">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57424">
        <property type="entry name" value="LDL receptor-like module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LDLRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MACPF_2"/>
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    </dbReference>
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        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0180">Complement pathway</keyword>
    <keyword evidence="14" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="19 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0473">Membrane attack complex</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="12 26" id="KW-0732">Signal</keyword>
    <keyword evidence="10 25" id="KW-0768">Sushi</keyword>
    <keyword evidence="8" id="KW-1052">Target cell membrane</keyword>
    <keyword evidence="21" id="KW-1053">Target membrane</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134056" description="Complement component C6" evidence="26">
        <location>
            <begin position="22"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="MACPF" evidence="28">
        <location>
            <begin position="176"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="27">
        <location>
            <begin position="642"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="27">
        <location>
            <begin position="702"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="29">
        <location>
            <begin position="785"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="672"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00093291"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00093528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="934" mass="105272" checksum="C7BD92576FEA413B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HEI8</accession>
    <name>A0A8B7HEI8_MICMU</name>
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        <recommendedName>
            <fullName evidence="2 9">Chromatin modification-related protein MEAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MEAF6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex. Component of the hbo1 complex. Component of the moz/morf complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the EAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001677">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635388.1">
        <property type="nucleotide sequence ID" value="XM_012779934.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HEI8"/>
    <dbReference type="Ensembl" id="ENSMICT00000043129.2">
        <property type="protein sequence ID" value="ENSMICP00000037349.1"/>
        <property type="gene ID" value="ENSMICG00000030115.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105879574"/>
    <dbReference type="CTD" id="64769"/>
    <dbReference type="GeneTree" id="ENSGT00390000015257"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070776">
        <property type="term" value="C:MOZ/MORF histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="191" mass="21662" checksum="1DFBDA4B6BAAF1E3" modified="2022-01-19" version="1">MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPNQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HGF6</accession>
    <name>A0A8B7HGF6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BTB domain containing 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BTBD10</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006363">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636193.1">
        <property type="nucleotide sequence ID" value="XM_012780739.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636194.1">
        <property type="nucleotide sequence ID" value="XM_012780740.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636195.1">
        <property type="nucleotide sequence ID" value="XM_012780741.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636196.1">
        <property type="nucleotide sequence ID" value="XM_012780742.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636198.1">
        <property type="nucleotide sequence ID" value="XM_012780744.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142155.1">
        <property type="nucleotide sequence ID" value="XM_020286566.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HGF6"/>
    <dbReference type="Ensembl" id="ENSMICT00000001230.3">
        <property type="protein sequence ID" value="ENSMICP00000001120.2"/>
        <property type="gene ID" value="ENSMICG00000001232.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880007"/>
    <dbReference type="CTD" id="84280"/>
    <dbReference type="GeneTree" id="ENSGT00390000007975"/>
    <dbReference type="OrthoDB" id="10034757at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18385">
        <property type="entry name" value="BTB_POZ_BTBD10_GMRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000017">
        <property type="entry name" value="BTB/POZ domain-containing protein 10 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039886">
        <property type="entry name" value="BTBD10/KCTD20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039885">
        <property type="entry name" value="BTBD10/KCTD20_BTB/POZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21637:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16017">
        <property type="entry name" value="BTB_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="108"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001120.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="475" mass="53908" checksum="88649C98A3857477" modified="2022-01-19" version="1">MAGRPHPYDSNSSDPENWDRKLHSRPRKLYKHSSTPSRIAKGGVDHTKMSLHGASGGHERSRDRRRSSDRSRDSSHERTESQLTPCIRNVTSPTRQHHVDREKDHSSSRPSSPRPQKASPNGSISSAGNSSRNSSQSSSDGSCKTSGEMVFVYENAKEGTRNIRMSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGIGSTVFRAILDYYKTGIIRCPDGISIPELREACDYLCISFEYSTIKCRDLSALMHELSNDGARRQFEFYLEEMILPLMVASAQSGERECHIVVLTDDDVVDWDEEYPPQMGEEYSQIIYSTKLYRFFKYIENRDVAKSVLKERGLKKIRLGIEGYPTYKEKVKKRPGGRPEVIYNYVQRPFIRMSWEKEEGKSRHVDFQCVKSKSITNLAAAAADIPQDQLVVMHPTPQVDELDILPIHPPSGNNDLDPDAQNPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HK90</accession>
    <name>A0A8B7HK90_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 35 member E3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLC35E3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Putative transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPT transporter family. SLC35E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009781">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637881.2">
        <property type="nucleotide sequence ID" value="XM_012782427.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HK90"/>
    <dbReference type="Ensembl" id="ENSMICT00000048878.2">
        <property type="protein sequence ID" value="ENSMICP00000019990.1"/>
        <property type="gene ID" value="ENSMICG00000029927.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880995"/>
    <dbReference type="KEGG" id="mmur:105880995"/>
    <dbReference type="CTD" id="55508"/>
    <dbReference type="GeneTree" id="ENSGT00730000111164"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="8">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="313" mass="34813" checksum="D8D0382EF570257D" modified="2022-01-19" version="1">MASLADRVRGSGRIAAGLLFNLLVSICIVFLNKWIYVHHGFPNMSLTLVHFVVTWLGLYICQKLDIFAPKSLPPSKLLLLALSFCGFVVFTNLSLQNNTIGTYQLAKAMTTPVIIAIQTFCYQKTFSTRIQLTLIPITLGVILNSYYDVKFNFLGMVFAALGVLVTSLYQVWVGAKQHELQVNSMQLLYYQAPMSSAMLLVTVPFFEPMFGEGGIFGPWSVSALLMVLLSGVIAFMVNLSIYWIIGNTSPVTYNMFGHFKFCITLFGGYVLFKDPLSVNQGLGILCTLFGILAYTHFKLSEQEGSKSKLVQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HM47</accession>
    <name>A0A8B7HM47_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Dedicator of cytokinesis 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">DOCK5</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023703">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637594.2">
        <property type="nucleotide sequence ID" value="XM_012782140.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070015.1">
        <property type="protein sequence ID" value="ENSMICP00000043273.1"/>
        <property type="gene ID" value="ENSMICG00000016726.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880831"/>
    <dbReference type="CTD" id="80005"/>
    <dbReference type="GeneTree" id="ENSGT00940000157734"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002102">
        <property type="term" value="C:podosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046849">
        <property type="term" value="P:bone remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007520">
        <property type="term" value="P:myoblast fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904694">
        <property type="term" value="P:negative regulation of vascular associated smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071800">
        <property type="term" value="P:podosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010634">
        <property type="term" value="P:positive regulation of epithelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900026">
        <property type="term" value="P:positive regulation of substrate adhesion-dependent cell spreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904754">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016601">
        <property type="term" value="P:Rac protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11708">
        <property type="entry name" value="DHR2_DOCK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12051">
        <property type="entry name" value="SH3_DOCK1_5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.410:FF:000004">
        <property type="entry name" value="Dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000044">
        <property type="entry name" value="dedicator of cytokinesis protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.350:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000057">
        <property type="entry name" value="Dedicator of cytokinesis protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030717">
        <property type="entry name" value="DHR2_DOCK5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047025">
        <property type="entry name" value="DOCK1_5_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF3">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="8"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="12">
        <location>
            <begin position="443"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="13">
        <location>
            <begin position="1231"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1680"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1773"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1783"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1796"/>
            <end position="1805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1860"/>
            <end position="1869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1869" mass="214777" checksum="A1FC520A32C58BDD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HSY0</accession>
    <name>A0A8B7HSY0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Melatonin receptor type 1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">MTNR1A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018811">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640323.1">
        <property type="nucleotide sequence ID" value="XM_012784869.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HSY0"/>
    <dbReference type="SMR" id="A0A8B7HSY0"/>
    <dbReference type="Ensembl" id="ENSMICT00000059430.1">
        <property type="protein sequence ID" value="ENSMICP00000045842.1"/>
        <property type="gene ID" value="ENSMICG00000046958.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882472"/>
    <dbReference type="KEGG" id="mmur:105882472"/>
    <dbReference type="CTD" id="4543"/>
    <dbReference type="GeneTree" id="ENSGT00940000160321"/>
    <dbReference type="OrthoDB" id="10044919at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042562">
        <property type="term" value="F:hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008502">
        <property type="term" value="F:melatonin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007193">
        <property type="term" value="P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000056">
        <property type="entry name" value="Melatonin receptor type 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002278">
        <property type="entry name" value="Mel_1A/1B_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000025">
        <property type="entry name" value="Melatonin_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228">
        <property type="entry name" value="B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24228:SF53">
        <property type="entry name" value="MELATONIN RECEPTOR TYPE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01149">
        <property type="entry name" value="MELATONIN1AR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00857">
        <property type="entry name" value="MELATONINR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="192"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="47"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="353" mass="39622" checksum="34B2FAF0D7F88289" modified="2022-01-19" version="1">MKGNGSALLNASQQAPGGGDGARPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNAGNVFVVSLAVADLVVAVYPYPLVLTSIFNNGWNLGYLHCQISAFVMGLSVIGSIFNITGIAVNRYCYICHSLKYDRLYSNKNSLCYVVVIWLLTVVAIVPNLRTGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFIIPMVIVSFCYLRIWILVLQVRRRVKPDNRPKLKPQDVRNFVTMFVVFVLFAICWAPLNFIGLAVASDPANMVARIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARMFFVDSSNDVADRIKCKPSPLMTNNNLIKVDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I4M0</accession>
    <name>A0A8B7I4M0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bromodomain and WD repeat-containing protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">BRWD3</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645783.1">
        <property type="nucleotide sequence ID" value="XM_012790329.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000063696.1">
        <property type="protein sequence ID" value="ENSMICP00000040523.1"/>
        <property type="gene ID" value="ENSMICG00000007517.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885418"/>
    <dbReference type="CTD" id="254065"/>
    <dbReference type="GeneTree" id="ENSGT00950000183107"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05529">
        <property type="entry name" value="Bromo_WDR9_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000071">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000003">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000008">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000034">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000222">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000328">
        <property type="entry name" value="Bromodomain and WD repeat domain containing 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
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        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="BROMODOMAIN AND WD REPEAT-CONTAINING PROTEIN 3"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
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            <begin position="461"/>
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            <begin position="1158"/>
            <end position="1228"/>
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            <begin position="1317"/>
            <end position="1411"/>
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            <begin position="1547"/>
            <end position="1724"/>
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            <begin position="769"/>
            <end position="778"/>
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        <source>
            <dbReference type="PROSITE" id="PS50014"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040523.1"/>
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    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1801" mass="203677" checksum="521D6766C434EAE4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I5J5</accession>
    <name>A0A8B7I5J5_MICMU</name>
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        <submittedName>
            <fullName evidence="15">Zinc finger protein 177</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF177</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03027850">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7I5J5"/>
    <dbReference type="Ensembl" id="ENSMICT00000004185.3">
        <property type="protein sequence ID" value="ENSMICP00000003815.2"/>
        <property type="gene ID" value="ENSMICG00000004189.3"/>
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    <dbReference type="Ensembl" id="ENSMICT00000050068.2">
        <property type="protein sequence ID" value="ENSMICP00000029658.2"/>
        <property type="gene ID" value="ENSMICG00000004189.3"/>
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    <dbReference type="KEGG" id="mmur:105885616"/>
    <dbReference type="GeneTree" id="ENSGT00940000163463"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:002971">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 197"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zinc finger protein 24"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
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        <property type="entry name" value="KRAB"/>
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        <property type="entry name" value="KRAB_dom_sf"/>
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        <property type="entry name" value="Znf_C2H2-type"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
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        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="40"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="485"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="541"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029658.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="570" mass="65585" checksum="2D8C8612A083AAED" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WQS3</accession>
    <name>A0A8B7WQS3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ectodysplasin A2 receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EDA2R</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    <dbReference type="EMBL" id="ABDC03002544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_020137666.1">
        <property type="nucleotide sequence ID" value="XM_020282077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WQS3"/>
    <dbReference type="Ensembl" id="ENSMICT00000038333.2">
        <property type="protein sequence ID" value="ENSMICP00000028923.1"/>
        <property type="gene ID" value="ENSMICG00000032599.2"/>
    </dbReference>
    <dbReference type="CTD" id="60401"/>
    <dbReference type="GeneTree" id="ENSGT00940000153259"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005031">
        <property type="term" value="F:tumor necrosis factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046330">
        <property type="term" value="P:positive regulation of JNK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15838">
        <property type="entry name" value="TNFRSF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000003">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001368">
        <property type="entry name" value="TNFR/NGFR_Cys_rich_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022319">
        <property type="entry name" value="TNFR_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034060">
        <property type="entry name" value="TNFRSF27_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047526">
        <property type="entry name" value="TNR19/27/EDAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120">
        <property type="entry name" value="TNFR-CYS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12120:SF8">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00020">
        <property type="entry name" value="TNFR_c6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01973">
        <property type="entry name" value="TNFACTORR27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00208">
        <property type="entry name" value="TNFR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00652">
        <property type="entry name" value="TNFR_NGFR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50050">
        <property type="entry name" value="TNFR_NGFR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="12">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="TNFR-Cys" evidence="12">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="repeat" description="TNFR-Cys" evidence="9">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="300" mass="33263" checksum="4BE898D72985D8A8" modified="2022-01-19" version="1">MDCQENEYWDQWGRCVTCQQCGPGQELSKDCGYGEGGDAYCTTCPPRRYKSSWGHHRCQTCITCAVINRVQKANCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVKADVPTVPPQEATLVALVSSLLVVFTLAFLGLLFLYCKQFFSRHCQRGDSLQFEIDEAAEEESLFPMPPGQETNPESTVSESTFETQPLNPILEDDCSSTRGFPTQESFTMASCASESHSHWVHNPIECTELDLQKFSSSASYIGAETLGEKTAESSGDKLELNAPFEVPHPQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WTN2</accession>
    <name>A0A8B7WTN2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EIF2B1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024801">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138716.1">
        <property type="nucleotide sequence ID" value="XM_020283127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WTN2"/>
    <dbReference type="Ensembl" id="ENSMICT00000059403.1">
        <property type="protein sequence ID" value="ENSMICP00000043065.1"/>
        <property type="gene ID" value="ENSMICG00000006480.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880863"/>
    <dbReference type="CTD" id="1967"/>
    <dbReference type="GeneTree" id="ENSGT00550000074853"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000001">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
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    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00043898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="305" mass="33768" checksum="0EB014F457203B0E" modified="2022-01-19" version="1">MDDKELIEYFKSQIKEDPDMASAVAAIRTLLEFLKRDKGETIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLTSLEYSDYSKCKKIMIERGELFLRRISLSRSKIADLCHTFIKDGAKILTHAYSRVVLRVLEAAVAAKKRFSVYITESRPDLSGKKMANALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFPLNQQDVPDKFKYKADTLKSVQTGQDLKEEHPWVDYTAPSLITLLFTDLGVLTPSAVSDELIKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UHT2</accession>
    <name>A0A8C5UHT2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Gamma-aminobutyric acid type A receptor subunit beta3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GABRB3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013541">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615459.1">
        <property type="nucleotide sequence ID" value="XM_012760005.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UHT2"/>
    <dbReference type="Ensembl" id="ENSMICT00000000031.3">
        <property type="protein sequence ID" value="ENSMICP00000000029.3"/>
        <property type="gene ID" value="ENSMICG00000027069.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105868828"/>
    <dbReference type="KEGG" id="mmur:105868828"/>
    <dbReference type="CTD" id="2562"/>
    <dbReference type="GeneTree" id="ENSGT00940000154713"/>
    <dbReference type="OrthoDB" id="8890589at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902711">
        <property type="term" value="C:GABA-A receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005230">
        <property type="term" value="F:extracellular ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007268">
        <property type="term" value="P:chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18999">
        <property type="entry name" value="LGIC_ECD_GABAAR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19053">
        <property type="entry name" value="LGIC_TM_GABAAR_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000004">
        <property type="entry name" value="Gamma-aminobutyric acid receptor subunit beta-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002289">
        <property type="entry name" value="GABAAb_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01160">
        <property type="entry name" value="GABAARBETA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 19" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044039434" evidence="19">
        <location>
            <begin position="26"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="452"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="20">
        <location>
            <begin position="39"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="21">
        <location>
            <begin position="250"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000029.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="471" mass="53913" checksum="5660C06E3044142E" modified="2022-01-19" version="1">MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVAGSVGDTRNSAISFDNSGIQYRKQSMPREGRFAGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UKJ9</accession>
    <name>A0A8C5UKJ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase CBL</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CBLC</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03026734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UKJ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000000852.3">
        <property type="protein sequence ID" value="ENSMICP00000000767.3"/>
        <property type="gene ID" value="ENSMICG00000000852.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000036537.2">
        <property type="protein sequence ID" value="ENSMICP00000030403.1"/>
        <property type="gene ID" value="ENSMICG00000000852.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162336"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001784">
        <property type="term" value="F:phosphotyrosine residue binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030971">
        <property type="term" value="F:receptor tyrosine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042059">
        <property type="term" value="P:negative regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990790">
        <property type="term" value="P:response to glial cell derived neurotrophic factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09920">
        <property type="entry name" value="SH2_Cbl-b_TKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000367">
        <property type="entry name" value="Cbl proto-oncogene C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000182">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.20:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase CBL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024162">
        <property type="entry name" value="Adaptor_Cbl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014741">
        <property type="entry name" value="Adaptor_Cbl_EF_hand-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003153">
        <property type="entry name" value="Adaptor_Cbl_N_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014742">
        <property type="entry name" value="Adaptor_Cbl_SH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024159">
        <property type="entry name" value="Cbl_PTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007">
        <property type="entry name" value="CBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23007:SF12">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CBL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02262">
        <property type="entry name" value="Cbl_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02761">
        <property type="entry name" value="Cbl_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02762">
        <property type="entry name" value="Cbl_N3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47668">
        <property type="entry name" value="N-terminal domain of cbl (N-cbl)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51506">
        <property type="entry name" value="CBL_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cbl-PTB" evidence="9">
        <location>
            <begin position="53"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="397"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000767.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="547" mass="60861" checksum="81D65C02B74C1794" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UKN4</accession>
    <name>A0A8C5UKN4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21 25">P2X purinoceptor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">P2X purinoceptor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">P2RX4</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Could also function as an ATP-gated cation channel of lysosomal membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="25">Receptor for ATP that acts as a ligand-gated ion channel.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="21">Functional P2XRs are organized as homomeric and heteromeric trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="25">Membrane</location>
            <topology evidence="25">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21 25">Belongs to the P2X receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024853">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UKN4"/>
    <dbReference type="GlyCosmos" id="A0A8C5UKN4">
        <property type="glycosylation" value="1 site, No reported glycans"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000001954.3">
        <property type="protein sequence ID" value="ENSMICP00000001784.3"/>
        <property type="gene ID" value="ENSMICG00000001947.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230351"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004931">
        <property type="term" value="F:extracellularly ATP-gated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001614">
        <property type="term" value="F:purinergic nucleotide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.490.10:FF:000001">
        <property type="entry name" value="P2X purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.940:FF:000010">
        <property type="entry name" value="P2X receptor E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.940">
        <property type="entry name" value="atp-gated p2x4 ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.490.10">
        <property type="entry name" value="atp-gated p2x4 ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003047">
        <property type="entry name" value="P2X4_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027309">
        <property type="entry name" value="P2X_extracellular_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001429">
        <property type="entry name" value="P2X_purnocptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059116">
        <property type="entry name" value="P2X_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053792">
        <property type="entry name" value="P2X_RECEPTOR_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00863">
        <property type="entry name" value="P2X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125">
        <property type="entry name" value="P2X PURINOCEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10125:SF18">
        <property type="entry name" value="P2X PURINOCEPTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00864">
        <property type="entry name" value="P2X_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005713">
        <property type="entry name" value="P2X_purinoceptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01311">
        <property type="entry name" value="P2X4RECEPTOR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01307">
        <property type="entry name" value="P2XRECEPTOR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01212">
        <property type="entry name" value="P2X_RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 23" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 25" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 21 25" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 21" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="15" id="KW-0458">Lysosome</keyword>
    <keyword evidence="11 21 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 25" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 21 25" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits of the homotrimer</note>
        </ligand>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="24">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="23">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR005713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR005713-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001784.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="388" mass="43727" checksum="2E5CBE32BC25C905" modified="2022-01-19" version="1">MAGCCEVLRPFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQEMDSVVSSVTTKVKGVAMTNTSKLGFRIWDVADYVIPPQEENSLFIMTNMILTMNQTQGTCPEIPDKTTVCTSDANCTAGSAGTHSNGVSTGRCVPFDGSVKTCEVAAWCPVEDDTHVPKPAFLRAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDARTDPFCPIFRLGDIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAAALCLPKYSFRRLDTRDVDHNVSPGYNFRFAKYYNDFAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGVATVLCDVIVLYCMKKRYYYREKKYKYVEDYEQGLASESDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UL23</accession>
    <name>A0A8C5UL23_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">BNIPL</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002978">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002979">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UL23"/>
    <dbReference type="Ensembl" id="ENSMICT00000000464.3">
        <property type="protein sequence ID" value="ENSMICP00000000423.2"/>
        <property type="gene ID" value="ENSMICG00000000460.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161723"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040009">
        <property type="term" value="P:regulation of growth rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000012">
        <property type="entry name" value="bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022181">
        <property type="entry name" value="Bcl2-/adenovirus-E1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF21">
        <property type="entry name" value="BCL-2_ADENOVIRUS E1B 19 KDA-INTERACTING PROTEIN 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12496">
        <property type="entry name" value="BNIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="6">
        <location>
            <begin position="192"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00065286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000423.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="358" mass="39904" checksum="7B5A551B5B4EB499" modified="2022-01-19" version="1">MGTVQEAGKKTLDLGENAETAELEAALRLGELELKEEWQDEEFPRLLPEEVGPSEDPEDPKGVLDSSPVKGTPNTLALCGQRPMRKRLSAPESWLNLTEGPGDNEASPTHSAPSSPDGSSDLEVDELETPSDSEQLDSGHEFEWEDELPQTEGLGASEAAERLGQGCMWDVAGEDGRRWRVFRTGQREQRVDMTVIDPYKKVLSHGGYHGDGLNAVILFASCYLPRSSIPNYTYVMEHLFKYMVGTLELLVAENYMLVHLSGGTSRAQVPPLSWIRQCYHTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFARKIRFLDSLGELAQLISLDQIHIPEAVRQLDQDLHGSGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5URA1</accession>
    <name>A0A8C5URA1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Zinc finger protein 79</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF79</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5URA1"/>
    <dbReference type="Ensembl" id="ENSMICT00000002321.3">
        <property type="protein sequence ID" value="ENSMICP00000002121.3"/>
        <property type="gene ID" value="ENSMICG00000002323.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163270"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000144">
        <property type="entry name" value="zinc finger protein 181 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000745">
        <property type="entry name" value="zinc finger protein 181 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000824">
        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000944">
        <property type="entry name" value="zinc finger protein 232 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002259">
        <property type="entry name" value="zinc finger protein 271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000352">
        <property type="entry name" value="zinc finger protein 3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF96">
        <property type="entry name" value="GENE, 32687-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002121.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="488" mass="54968" checksum="F426136514938C73" modified="2022-01-19" version="1">MLEEGVPPSSDTALPQKESTREERMAAGLLTAGPQFAQEGWRHLVPTPRDRFKEGIPEKSRNLVLLGLPVSQSGVNSQLEQREGPWMLEGEDLRSSCPDWKIILESPPEQASSEESSQDTNVEMAPRESDHRISELGKSFNLRPVLSPQQRVPTEVRTRKCETHAKNFKKNSEIIDPHRVKPYTCNECGKAFSYCSSLSQHQKSHTGEKPYECNECGKAFSQSSSLIQHQRIHTGEKPYKCSECGRAFSQNANLTKHQRTHTGEKPYKCSECDKAFSDCSALVQHQRIHTGEKPYECSDCGKAFRHSANLTNHQRTHTGEKPYKCTECGKAFSYCAAFIQHQRIHTGEKPYKCNACGKAFSQSANLTNHQRTHTGEKPYKCSECGKAFSQSTNLIIHQKTHTGEKPYKCNECGKFFSESSALIRHHIIHTGEKPYECSVCGKAFNQSSSLSQHQRIHTGMKPYECSECGKAFRCSSAFIRHQRLHAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVH6</accession>
    <name>A0A8C5UVH6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Glutaminyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">QARS1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Glutamine--tRNA ligase. Plays a critical role in brain development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Monomer. Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18. Interacts with RARS1. Part of a complex composed of RARS1, QARS1 and AIMP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03018196">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626684.1">
        <property type="nucleotide sequence ID" value="XM_012771230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVH6"/>
    <dbReference type="Ensembl" id="ENSMICT00000007887.3">
        <property type="protein sequence ID" value="ENSMICP00000007182.1"/>
        <property type="gene ID" value="ENSMICG00000007885.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874947"/>
    <dbReference type="KEGG" id="mmur:105874947"/>
    <dbReference type="CTD" id="5859"/>
    <dbReference type="GeneTree" id="ENSGT00550000074972"/>
    <dbReference type="OMA" id="TWCIYPM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001234">
        <property type="term" value="P:negative regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032873">
        <property type="term" value="P:negative regulation of stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2420:FF:000004">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1290:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000008">
        <property type="entry name" value="probable glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000049">
        <property type="entry name" value="Probable glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000006">
        <property type="entry name" value="Putative glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1290">
        <property type="entry name" value="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007638">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007639">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042558">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042559">
        <property type="entry name" value="Gln-tRNA-synth_Ib_RNA-bd_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04558">
        <property type="entry name" value="tRNA_synt_1c_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04557">
        <property type="entry name" value="tRNA_synt_1c_R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9 17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminyl-tRNA synthetase class Ib non-specific RNA-binding" evidence="20">
        <location>
            <begin position="165"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="18">
        <location>
            <begin position="263"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="19">
        <location>
            <begin position="565"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="22">
        <location>
            <begin position="677"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030466"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058106"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062609"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00073804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04558"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="775" mass="87887" checksum="AB16D4113B2FFF5F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UY37</accession>
    <name>A0A8C5UY37_MICMU</name>
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        <submittedName>
            <fullName evidence="7">SLAM family member 9</fullName>
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    <gene>
        <name evidence="7" type="primary">SLAMF9</name>
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    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000011363.3"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="CD2/SLAM_rcpt"/>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010342.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="289" mass="32248" checksum="DF8D4DD04A3BB9FC" modified="2022-01-19" version="1">PSRGLPSCLELASQIAAKGDSGDDVDPEEVVAVLHESIYLPLEIPSDEEVEDIIWYSHKRLAIVVPEKEGRPANITVTDPHYRGRVSFLEPSYSLYISNLSWEDAGLYQARVNLGTSQIFATRDYDLRVYQRLSELQITVNFEISGERTCNMSLTCSVEKAGMDVTYSWLSWGDNTDTVHEGPVLSASWRPGDSAPSYTCRASNPVSNASSHPIPAGSFCADPGYPSEKPSTAFCLLAKGLLFLFLLVILAVGLWVIRVWKRDKMPRMKKLRRNRMKLKKRRTPGPSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZP4</accession>
    <name>A0A8C5UZP4_MICMU</name>
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        <recommendedName>
            <fullName evidence="13">G-protein coupled receptors family 1 profile domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="14" type="primary">LOC105859909</name>
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        <name type="scientific">Microcebus murinus</name>
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        <lineage>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="function">
        <text evidence="1">Odorant receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000012966.3">
        <property type="protein sequence ID" value="ENSMICP00000011815.3"/>
        <property type="gene ID" value="ENSMICG00000012975.3"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26453">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0552">Olfaction</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="11" id="KW-0807">Transducer</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="41"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011815.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="316" mass="35199" checksum="2E1F38FF6BBF19DF" modified="2022-01-19" version="1">MELWNSTLGRGFILVGILNDSGSPELLCATLAVLYMLALISNGLLLLVITMDAQLHVPMYLLLGQLSLMDLLFTSVVTPKALIDFLRRENIITFGGCALQMFLALTLGGAEDLLLAFMAYDRYVAICHPLNYMVLMRPSVCWFMVATSWILAFLSALGHTIYTMHYPFCKAQKIRHLLCEIPPLLRLACADTSRYELMVYVMGVTFLIPPLAAILASYMLILFTVFHMPSNEGRKKALITCSSHLTVVGMFYGAATSMYVLPSSFHSPKQDSIISVFYTIVTPALNPLIYSLRNKEVMGALRRVLGKHILPTRSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V0F4</accession>
    <name>A0A8C5V0F4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoribonuclease Dicer</fullName>
            <ecNumber evidence="4">3.1.26.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DICER1</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="19 20">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03003519">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000011710.3">
        <property type="protein sequence ID" value="ENSMICP00000010659.2"/>
        <property type="gene ID" value="ENSMICG00000011690.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156287"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016442">
        <property type="term" value="C:RISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070578">
        <property type="term" value="C:RISC-loading complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004530">
        <property type="term" value="F:deoxyribonuclease I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061980">
        <property type="term" value="F:regulatory RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15903">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02843">
        <property type="entry name" value="PAZ_dicer_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000023">
        <property type="entry name" value="Endoribonuclease dcr-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000628">
        <property type="entry name" value="Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000002">
        <property type="entry name" value="Endoribonuclease Dicer isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000588">
        <property type="entry name" value="Endoribonuclease Dicer isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000005">
        <property type="entry name" value="Putative endoribonuclease dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.260.10:FF:000002">
        <property type="entry name" value="Putative Endoribonuclease Dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048513">
        <property type="entry name" value="Dicer_PBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048512">
        <property type="entry name" value="Dicer_platform"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20930">
        <property type="entry name" value="Dicer_PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20931">
        <property type="entry name" value="Dicer_platform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="15 20" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="16" id="KW-0943">RNA-mediated gene silencing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="24">
        <location>
            <begin position="51"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="25">
        <location>
            <begin position="433"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="26">
        <location>
            <begin position="630"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="23">
        <location>
            <begin position="895"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="22">
        <location>
            <begin position="1284"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="22">
        <location>
            <begin position="1666"/>
            <end position="1765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1A0</accession>
    <name>A0A8C5V1A0_MICMU</name>
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        <submittedName>
            <fullName evidence="10">Mediator complex subunit 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED12</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Mediator_Med12_catenin-bd"/>
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        <property type="entry name" value="Mediator_Med12_LCEWAV"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF12145">
        <property type="entry name" value="Med12-LCEWAV"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Med12-PQL"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-0678">Repressor</keyword>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3L3</accession>
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        <recommendedName>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the kappa-casein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029042">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3L3"/>
    <dbReference type="Ensembl" id="ENSMICT00000015224.3">
        <property type="protein sequence ID" value="ENSMICP00000013889.3"/>
        <property type="gene ID" value="ENSMICG00000015230.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009184"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007595">
        <property type="term" value="P:lactation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000117">
        <property type="entry name" value="Casein_kappa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11470">
        <property type="entry name" value="KAPPA CASEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11470:SF2">
        <property type="entry name" value="KAPPA-CASEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00997">
        <property type="entry name" value="Casein_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002374">
        <property type="entry name" value="Casein_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0494">Milk protein</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034597104" description="Kappa-casein" evidence="11">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013889.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="182" mass="20340" checksum="788C47D9F2597E38" modified="2022-01-19" version="1">MKHFLLVVNVLVSTLPFLAAVVQNQERSACRENNERLFNQKTVSYVPILYMLNSYPHYEPNFYQRRPAILINSPYMPHTYYAKPAVYMPHAQIPQQQVLPNIHSPTMARHPHRHASLFAIPPKKIEAKTTIPTITTTATIEPTPILATEPVVNSVVLPEASSESITTSTPETTAVPVTSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3V9</accession>
    <name>A0A8C5V3V9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SIK2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03006873">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605006.1">
        <property type="nucleotide sequence ID" value="XM_012749552.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3V9"/>
    <dbReference type="Ensembl" id="ENSMICT00000015730.3">
        <property type="protein sequence ID" value="ENSMICP00000014331.2"/>
        <property type="gene ID" value="ENSMICG00000015724.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862926"/>
    <dbReference type="KEGG" id="mmur:105862926"/>
    <dbReference type="CTD" id="23235"/>
    <dbReference type="GeneTree" id="ENSGT00940000156445"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14071">
        <property type="entry name" value="STKc_SIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14409">
        <property type="entry name" value="UBA_SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000154">
        <property type="entry name" value="Serine/threonine-protein kinase SIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017090">
        <property type="entry name" value="Ser/Thr_kinase_SIK1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034672">
        <property type="entry name" value="SIK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057380">
        <property type="entry name" value="UBA_SIK1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF38">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23312">
        <property type="entry name" value="UBA_SIK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037014">
        <property type="entry name" value="Ser/Thr_PK_SNF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="20">
        <location>
            <begin position="295"/>
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        </location>
    </feature>
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        <location>
            <begin position="454"/>
            <end position="482"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="567"/>
            <end position="586"/>
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    </feature>
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        <location>
            <begin position="641"/>
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    <feature type="region of interest" description="Disordered" evidence="18">
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    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="796"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="657"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="739"/>
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    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="800"/>
            <end position="830"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="840"/>
            <end position="854"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="26"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 17">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR037014-2"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014331.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="923" mass="103371" checksum="3585494E96CD56F4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5R2</accession>
    <name>A0A8C5V5R2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Transient receptor potential cation channel subfamily V member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="primary">TRPV3</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="24">Non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. The channel pore can dilate to provide permeability to larger cations. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Mg(2+)(in) = Mg(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29827"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="26">Homotetramer. May convert from a homotetramer to a homopentamer to allow pore dilation. Interacts with TRPV1; may form a heteromeric channel with TRPV1. Interacts with SNX11; this interaction promotes TRPV3 trafficking from the cell membrane to lysosome for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV3 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020477">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5R2"/>
    <dbReference type="Ensembl" id="ENSMICT00000015686.3">
        <property type="protein sequence ID" value="ENSMICP00000014291.3"/>
        <property type="gene ID" value="ENSMICG00000015684.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158281"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005272">
        <property type="term" value="F:sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042636">
        <property type="term" value="P:negative regulation of hair cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007231">
        <property type="term" value="P:osmosensory signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009266">
        <property type="term" value="P:response to temperature stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22194">
        <property type="entry name" value="TRPV3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
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    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
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    <dbReference type="InterPro" id="IPR024862">
        <property type="entry name" value="TRPV"/>
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    <dbReference type="InterPro" id="IPR008347">
        <property type="entry name" value="TrpV1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582:SF6">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10582">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
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    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TRPVRECEPTOR"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 28" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="7" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="18" id="KW-0458">Lysosome</keyword>
    <keyword evidence="17 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="9 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="28">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="31">
        <location>
            <begin position="444"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="770"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="770"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="29">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00059213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00061094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00062999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014291.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="794" mass="90895" checksum="137518CDE014662C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6K0</accession>
    <name>A0A8C5V6K0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein UXT</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ubiquitously expressed transcript protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">UXT</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UXT family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6K0"/>
    <dbReference type="Ensembl" id="ENSMICT00000016268.3">
        <property type="protein sequence ID" value="ENSMICP00000014827.3"/>
        <property type="gene ID" value="ENSMICG00000016263.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018078"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990062">
        <property type="term" value="C:RPAP3/R2TP/prefoldin-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007098">
        <property type="term" value="P:centrosome cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23158">
        <property type="entry name" value="Prefoldin_UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000007">
        <property type="entry name" value="UXT isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003994">
        <property type="entry name" value="UXT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF9">
        <property type="entry name" value="PROTEIN UXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01502">
        <property type="entry name" value="UXTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00070776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014827.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="157" mass="18278" checksum="65DE14D9C869FEA2" modified="2022-01-19" version="1">MATPPKRRAVEATGEKVLRYETFISDVLQRDLRKVLDHRDKVYEQLAKYLQLRNVIERLQEAKHSELYMQVDLGCNFFVDTMVPDTSRIYVALGYGFFLELTLAEALKFIDRKSSLLTELSNSLTKDSMNIKAHIHMLLEGLRELQGLQNFPEKPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9P0</accession>
    <name>A0A8C5V9P0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03016540">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V9P0"/>
    <dbReference type="Ensembl" id="ENSMICT00000044109.2">
        <property type="protein sequence ID" value="ENSMICP00000018541.1"/>
        <property type="gene ID" value="ENSMICG00000031463.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000051272"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="137" mass="15159" checksum="399BFC81D2927F6D" modified="2022-01-19" version="1">MEAEGSSVPARAGSGEGSDGASGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRAMDRTSYAVETGHRPGLKKSRMSWPSSFQGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDL3</accession>
    <name>A0A8C5VDL3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">39S ribosomal protein L30, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDL3"/>
    <dbReference type="Ensembl" id="ENSMICT00000045699.2">
        <property type="protein sequence ID" value="ENSMICP00000020467.1"/>
        <property type="gene ID" value="ENSMICG00000031953.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016769"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
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    </dbReference>
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        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15327" checksum="FF1BFCAA1AAB7291" modified="2022-01-19" version="1">KVVQRPLGRLQTVTKGAESLICTDWIRHKFTRSRIPDKVFQPSPEDDEKYGGDPHNPHKLHIMLGLLKAHTPQVHKNIPSVNAKLKVVKHLIRIKPLKLPQGLPAEEDMSNTCLKSTGELVQWHLKPVEEETVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDP8</accession>
    <name>A0A8C5VDP8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LBH domain containing 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LBHD2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003704">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDP8"/>
    <dbReference type="Ensembl" id="ENSMICT00000038314.2">
        <property type="protein sequence ID" value="ENSMICP00000020531.2"/>
        <property type="gene ID" value="ENSMICG00000032097.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00610000087423"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038990">
        <property type="entry name" value="LBH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042945">
        <property type="entry name" value="LBH_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987:SF3">
        <property type="entry name" value="LBH DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14987">
        <property type="entry name" value="PROTEIN LBH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15317">
        <property type="entry name" value="Lbh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LBH" evidence="2">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="110" mass="10808" checksum="CE47DC690BF5570D" modified="2022-01-19" version="1">MSTSQPATAVAEPSPAEGARGPAGEAVVGTREKGPRLGQRLPSIVVEPSEAGAVESGELRWPPEGAQRGAAQSPAAAAPSPSPPVASGKAADDAGCKCASLEDQAPLAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHA0</accession>
    <name>A0A8C5VHA0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004743">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VHA0"/>
    <dbReference type="Ensembl" id="ENSMICT00000039148.2">
        <property type="protein sequence ID" value="ENSMICP00000018402.1"/>
        <property type="gene ID" value="ENSMICG00000034930.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00900000143730"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="99" mass="11379" checksum="F9F2DEA8CE877918" modified="2022-01-19" version="1">HVVSSMYVLLRQSLTPSHMAPWNKKTFSEVLPHRWVIETVCGDTNLSPWWRNLCLSTVFYSVYSDDKCNRIKPVNVKCVPHLWNLLSSLVSSVGDIFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJV9</accession>
    <name>A0A8C5VJV9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein tyrosine phosphatase 4A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PTP4A1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03008062">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJV9"/>
    <dbReference type="SMR" id="A0A8C5VJV9"/>
    <dbReference type="Ensembl" id="ENSMICT00000053143.2">
        <property type="protein sequence ID" value="ENSMICP00000024666.1"/>
        <property type="gene ID" value="ENSMICG00000047651.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154406"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000074">
        <property type="entry name" value="Protein tyrosine phosphatase type IVA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="148" mass="17101" checksum="63E2EF26BFBD5E3A" modified="2022-01-19" version="1">MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM69</accession>
    <name>A0A8C5VM69_MICMU</name>
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        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
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    </protein>
    <gene>
        <name evidence="4" type="primary">GGCT</name>
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    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="ABDC03015684">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM69"/>
    <dbReference type="Ensembl" id="ENSMICT00000045316.2">
        <property type="protein sequence ID" value="ENSMICP00000021293.1"/>
        <property type="gene ID" value="ENSMICG00000012142.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000044921"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="114" mass="13025" checksum="EAB6AC5495E1473F" modified="2022-01-19" version="1">MANSNFEDGRGQEEETFLYFAYGSNLLTERIHLRNPSAAFCCVARLKDFKLDFGNSQGKTSPTWHGGIATIFQSPGDEVWGIVWKMNKSNLNSLDELFAWVQKKMVCHWSTKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMA0</accession>
    <name>A0A8C5VMA0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein Sec61 subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028878">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMA0"/>
    <dbReference type="Ensembl" id="ENSMICT00000037531.2">
        <property type="protein sequence ID" value="ENSMICP00000021337.2"/>
        <property type="gene ID" value="ENSMICG00000036088.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003561"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="8778" checksum="37D805172FEB7623" modified="2022-01-19" version="1">MPAPTASGTHVRSSGRSPSKAGAARVAGSTVWQRKNASCGTQSAGTGGGGAEDSPGLKVGPIPVLVMSLLFIASVFMLQIWGKHTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQ40</accession>
    <name>A0A8C5VQ40_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019035">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQ40"/>
    <dbReference type="Ensembl" id="ENSMICT00000000730.3">
        <property type="protein sequence ID" value="ENSMICP00000024112.1"/>
        <property type="gene ID" value="ENSMICG00000000731.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017469"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="122" mass="13304" checksum="5567162ECD609553" modified="2022-01-19" version="1">MFLHSDSRSSLGSTKPTIVQGVDTHMHQTLGEGVTKDPMHLALQGEDKLGPIPKPTFPSSSLSPHSVWFSSPQMKDHGFPAGRNGLTQTSFTCQVPSGWGSPWGFFLPHQECNPLVRRPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VRK3</accession>
    <name>A0A8C5VRK3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 24">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="14 24">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">LOC105867979</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77126"/>
            <dbReference type="ChEBI" id="CHEBI:85351"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:45657"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45672"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77128"/>
            <dbReference type="ChEBI" id="CHEBI:85355"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:45673"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:85356"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:45677"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45652"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:72864"/>
            <dbReference type="ChEBI" id="CHEBI:85350"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:45653"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45668"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77130"/>
            <dbReference type="ChEBI" id="CHEBI:85354"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:45669"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45648"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77091"/>
            <dbReference type="ChEBI" id="CHEBI:85349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:45649"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45660"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:77098"/>
            <dbReference type="ChEBI" id="CHEBI:85352"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:45661"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:45664"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74560"/>
            <dbReference type="ChEBI" id="CHEBI:85353"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:45665"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16230"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 24">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 24">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="14 24"/>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRK3"/>
    <dbReference type="Ensembl" id="ENSMICT00000031900.2">
        <property type="protein sequence ID" value="ENSMICP00000028663.2"/>
        <property type="gene ID" value="ENSMICG00000033373.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158223"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF16">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="21 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="18 24" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="23" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="17 24 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00000859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00001056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00001617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00001729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00001902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028663.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="337" mass="39414" checksum="A3A55AB099064C93" modified="2022-01-19" version="1">VKCFHEIITIGYRVYRSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVVFGFTAAYVLSKYQYFVCPVEYRSDVNSFITECEPSELFRLQSYELPPFLWETVSLYPFQIHSVALSAFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYRTLKTHLIEKGLLQPALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VRQ0</accession>
    <name>A0A8C5VRQ0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105864398</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Golgi apparatus</location>
            <location evidence="3">cis-Golgi network membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Membrane</location>
            <topology evidence="11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013758">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013759">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013761">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013762">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VRQ0"/>
    <dbReference type="Ensembl" id="ENSMICT00000042048.2">
        <property type="protein sequence ID" value="ENSMICP00000028730.2"/>
        <property type="gene ID" value="ENSMICG00000030809.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159833"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034055775" description="GOLD domain-containing protein" evidence="13">
        <location>
            <begin position="27"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="14">
        <location>
            <begin position="38"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028730.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="218" mass="24465" checksum="ACDF5B788301D5A4" modified="2022-01-19" version="1">MAMRGPGCACCPLLLLLLLRAGQPRGAELTFELPDSARQCFHEDVEQGATFSLDYQCVITGGHYDVDCYVEDPQGTSSTRETKKQYDSFTHRAEVKGVYLFCFSNEFSTFSHKTVYFDLQVGEEPPILPDMGNRVTALTQMESACVTIREALKTVIDSQTHYRLREAQDRARAEDLNSRVSYWSVGETVVLFLASLGQVLLLKSFFTEKRPGSRAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VT53</accession>
    <name>A0A8C5VT53_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fibroblast growth factor</fullName>
            <shortName evidence="2">FGF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">FGF14</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the heparin-binding growth factors family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607306.1">
        <property type="nucleotide sequence ID" value="XM_012751852.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VT53"/>
    <dbReference type="Ensembl" id="ENSMICT00000054647.2">
        <property type="protein sequence ID" value="ENSMICP00000026640.1"/>
        <property type="gene ID" value="ENSMICG00000010747.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864172"/>
    <dbReference type="CTD" id="2259"/>
    <dbReference type="GeneTree" id="ENSGT00940000156984"/>
    <dbReference type="OrthoDB" id="6158176at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007267">
        <property type="term" value="P:cell-cell signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23330">
        <property type="entry name" value="beta-trefoil_FGF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000001">
        <property type="entry name" value="Fibroblast growth factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002209">
        <property type="entry name" value="Fibroblast_GF_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008996">
        <property type="entry name" value="IL1/FGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11486">
        <property type="entry name" value="FIBROBLAST GROWTH FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00167">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00263">
        <property type="entry name" value="HBGFFGF"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00262">
        <property type="entry name" value="IL1HBGF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00442">
        <property type="entry name" value="FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50353">
        <property type="entry name" value="Cytokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00247">
        <property type="entry name" value="HBGF_FGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU049442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="247" mass="27718" checksum="90E74F9A171B7F77" modified="2022-01-19" version="1">MAAAIASGLIRQKRQAREQHWDRLSASRRRSSPSKNRGLCNGNLVDIFSKVRIFGLKKRRLRRQDPQLKGIVTRLYCRQGYYLQMHPDGALDGTKDDSTNSTLFNLIPVGLRVVAIQGVKTGLYIAMNGEGYLYPSELFTPECKFKESVFENYYVIYSSMLYRQQESGRAWFLGLNKEGQAMKGNRVKKTKPAAHFLPKPLEVAMYREPSLHDVGETVPKPGVTPSKSTSASAIMNGGKPVNKSKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VTU6</accession>
    <name>A0A8C5VTU6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Distal-less homeobox 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DLX3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the distal-less homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645185.1">
        <property type="nucleotide sequence ID" value="XM_012789731.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VTU6"/>
    <dbReference type="SMR" id="A0A8C5VTU6"/>
    <dbReference type="Ensembl" id="ENSMICT00000038274.2">
        <property type="protein sequence ID" value="ENSMICP00000028871.2"/>
        <property type="gene ID" value="ENSMICG00000037127.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885101"/>
    <dbReference type="KEGG" id="mmur:105885101"/>
    <dbReference type="CTD" id="1747"/>
    <dbReference type="GeneTree" id="ENSGT00940000158951"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001568">
        <property type="term" value="P:blood vessel development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035315">
        <property type="term" value="P:hair cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071335">
        <property type="term" value="P:hair follicle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031069">
        <property type="term" value="P:hair follicle morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071895">
        <property type="term" value="P:odontoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042475">
        <property type="term" value="P:odontogenesis of dentin-containing tooth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001890">
        <property type="term" value="P:placenta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000048">
        <property type="entry name" value="Distal-less homeobox 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022135">
        <property type="entry name" value="Distal-less_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF28">
        <property type="entry name" value="HOMEOBOX PROTEIN DLX-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12413">
        <property type="entry name" value="DLL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028871.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="287" mass="31738" checksum="DCA9716E51D78DD1" modified="2022-01-19" version="1">MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSASPSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VW18</accession>
    <name>A0A8C5VW18_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Toll-interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TOLLIP</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates. In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tollip family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625004.1">
        <property type="nucleotide sequence ID" value="XM_012769550.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VW18"/>
    <dbReference type="Ensembl" id="ENSMICT00000051316.2">
        <property type="protein sequence ID" value="ENSMICP00000031499.2"/>
        <property type="gene ID" value="ENSMICG00000017219.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874059"/>
    <dbReference type="CTD" id="54472"/>
    <dbReference type="GeneTree" id="ENSGT00390000013104"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035325">
        <property type="term" value="F:Toll-like receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070498">
        <property type="term" value="P:interleukin-1-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036010">
        <property type="term" value="P:protein localization to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04016">
        <property type="entry name" value="C2_Tollip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14363">
        <property type="entry name" value="CUE_TOLIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000036">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000055">
        <property type="entry name" value="Toll-interacting protein-like Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041799">
        <property type="entry name" value="TOLIP_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037301">
        <property type="entry name" value="Tollip_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="8" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="35"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CUE" evidence="12">
        <location>
            <begin position="230"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00053704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031499.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="275" mass="30303" checksum="EE6CFCD6E55E1D70" modified="2022-01-19" version="1">MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGAVGAVGRLNVTVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHVTIPESLKQEGAVEDKWYCLSGRQGDDKEGMINLVMSYSLLPATMVMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPVAVPPPAVSAQPRCSEEDLKAIQDMFPNMDRDVIRSVLEAQRGNRDAAINSLLQMGEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VW68</accession>
    <name>A0A8C5VW68_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Non-histone chromosomal protein HMG-14</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017176">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VW68"/>
    <dbReference type="Ensembl" id="ENSMICT00000046630.2">
        <property type="protein sequence ID" value="ENSMICP00000031528.2"/>
        <property type="gene ID" value="ENSMICG00000037397.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182802"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031492">
        <property type="term" value="F:nucleosomal DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000079">
        <property type="entry name" value="HMGN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087:SF12">
        <property type="entry name" value="NON-HISTONE CHROMOSOMAL PROTEIN HMG-14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23087">
        <property type="entry name" value="NONHISTONE CHROMOSOMAL PROTEIN HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01101">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00925">
        <property type="entry name" value="NONHISHMG17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00527">
        <property type="entry name" value="HMG17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00355">
        <property type="entry name" value="HMG14_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031528.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="97" mass="10327" checksum="961BA399F0757B88" modified="2022-01-19" version="1">MPKRKVSSAEGAPKRRSARLSAKPAPAKVEAKPKKAAAKDKSSDKKEQPKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEVKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W1J1</accession>
    <name>A0A8C5W1J1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin-protein ligase MARCHF7</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Membrane-associated RING finger protein 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Membrane-associated RING-CH protein VII</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase MARCHF7</fullName>
        </alternativeName>
    </protein>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its uibiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03001420">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W1J1"/>
    <dbReference type="Ensembl" id="ENSMICT00000054933.2">
        <property type="protein sequence ID" value="ENSMICP00000031675.2"/>
        <property type="gene ID" value="ENSMICG00000012681.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063836"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16812">
        <property type="entry name" value="RING_CH-C4HC3_MARCH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000108">
        <property type="entry name" value="E3 ubiquitin-protein ligase MARCH7 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052297">
        <property type="entry name" value="RING-CH-type_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCHF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14471">
        <property type="entry name" value="MARCH7/10 E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="19">
        <location>
            <begin position="474"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="146"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="613"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00083915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00084030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031675.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="634" mass="69936" checksum="DA58F5C1E48492CD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W243</accession>
    <name>A0A8C5W243_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ADP-ribosylation factor-like protein 6-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017822">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W243"/>
    <dbReference type="Ensembl" id="ENSMICT00000039754.2">
        <property type="protein sequence ID" value="ENSMICP00000034973.2"/>
        <property type="gene ID" value="ENSMICG00000027752.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154937"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006613">
        <property type="term" value="P:cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052114">
        <property type="entry name" value="ER_autophagy_membrane_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952:SF0">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20952">
        <property type="entry name" value="ADP-RIBOSYLATION-LIKE FACTOR 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034973.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16231" checksum="0A850C51BDACDD67" modified="2022-01-19" version="1">VAEGDNRSTNLLAAETASPEEQLQGWGEVMLITDKVARWERAWSPPATMGVVSLVFLIIYYLDPPVLSGVSCFVMFLCLADYLVPILAPRILGSNKFHEICSNLVKTWCRAVGWWKHLFTLKEEKPKILLFLFCMTRCDYCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W347</accession>
    <name>A0A8C5W347_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADH:ubiquinone oxidoreductase complex assembly factor 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">NDUFAF8</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000026980.2"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
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    </evidence>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="6">Transmembrane protein 241</fullName>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022975">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012746101.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W544"/>
    <dbReference type="Ensembl" id="ENSMICT00000042384.2">
        <property type="protein sequence ID" value="ENSMICP00000037111.1"/>
        <property type="gene ID" value="ENSMICG00000009287.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860938"/>
    <dbReference type="CTD" id="85019"/>
    <dbReference type="GeneTree" id="ENSGT00510000048348"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
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            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="57"/>
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    </feature>
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        </location>
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        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="296" mass="32750" checksum="1B687160C0CD2F78" modified="2022-01-19" version="1">MCVRRSLVGLTFCTCYLASYLTNKYVLSVLKFTYPTLFQGWQTFIGGLLLHVLWKLGWVEINSSLRSNVLTWLPASVLFVGIIYAGSRALSRLAIPVFLTLHNVAEVIICGYQKCFRKEKTSPAKICSALFLLAAAGCLPFNDSQFDPDGYFWAVIHLLCVGAYKILQKSQKPSALSDIDQQYLNYIFSVVLLAFASHPTGDLFSVLDFPFLYFYRFHGSCCASGFLGFFLMFSTVKLKSLLAPGQCAAWIFFAKVITAGLSTLLFDAILTSATVGCLLLGGLGEALLVFSERRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XCI8</accession>
    <name>A0A8C5XCI8_MICMU</name>
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            <fullName evidence="10">Cilia and flagella associated protein 65</fullName>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010757">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XCI8"/>
    <dbReference type="Ensembl" id="ENSMICT00000007063.3">
        <property type="protein sequence ID" value="ENSMICP00000006433.2"/>
        <property type="gene ID" value="ENSMICG00000007043.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00430000031142"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007288">
        <property type="term" value="P:sperm axoneme assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="CFAP65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053879">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058536">
        <property type="entry name" value="Ig_CFAP65_4th"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46127:SF1">
        <property type="entry name" value="CILIA- AND FLAGELLA-ASSOCIATED PROTEIN 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22544">
        <property type="entry name" value="HYDIN_VesB_CFA65-like_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24507">
        <property type="entry name" value="Ig_CFAP65_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HYDIN/VesB/CFA65-like Ig-like" evidence="6">
        <location>
            <begin position="183"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CFAP65 fourth Ig-like" evidence="7">
        <location>
            <begin position="405"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006433.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="79883" checksum="1A712DE8F0D0802E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEV5</accession>
    <name>A0A8C5XEV5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxynitrite isomerase THAP4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">THAP domain-containing protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">THAP4</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:63117"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the nitrobindin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010559">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611102.1">
        <property type="nucleotide sequence ID" value="XM_012755648.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEV5"/>
    <dbReference type="Ensembl" id="ENSMICT00000016444.3">
        <property type="protein sequence ID" value="ENSMICP00000014988.2"/>
        <property type="gene ID" value="ENSMICG00000016452.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866387"/>
    <dbReference type="KEGG" id="mmur:105866387"/>
    <dbReference type="CTD" id="51078"/>
    <dbReference type="GeneTree" id="ENSGT00940000158447"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070026">
        <property type="term" value="F:nitric oxide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006570">
        <property type="term" value="P:tyrosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.20:FF:000014">
        <property type="entry name" value="THAP domain-containing protein 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.20">
        <property type="entry name" value="THAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038441">
        <property type="entry name" value="THAP_Znf_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854:SF4">
        <property type="entry name" value="PEROXYNITRITE ISOMERASE THAP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="THAP4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 21" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="24">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="82"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="240"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="373"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00071981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014988.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="577" mass="63042" checksum="1426AE1B59887ADA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XFS5</accession>
    <name>A0A8C5XFS5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Palladin, cytoskeletal associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PALLD</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
            <location evidence="1">Z line</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the myotilin/palladin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018876">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XFS5"/>
    <dbReference type="Ensembl" id="ENSMICT00000052940.2">
        <property type="protein sequence ID" value="ENSMICP00000017984.2"/>
        <property type="gene ID" value="ENSMICG00000036078.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153441"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030018">
        <property type="term" value="C:Z disc"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05892">
        <property type="entry name" value="IgI_Myotilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000032">
        <property type="entry name" value="palladin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000761">
        <property type="entry name" value="palladin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001108">
        <property type="entry name" value="palladin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633">
        <property type="entry name" value="IMMUNOGLOBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47633:SF10">
        <property type="entry name" value="PALLADIN, CYTOSKELETAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="69"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="187"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="285"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017984.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="435" mass="47864" checksum="35BD2AED0478E6DA" modified="2022-01-19" version="1">MARRLLGADSATVFNIQEPEEDTAHQEYKVSSCEQRLISEIEYRLERSAVDESGDEGVGDAPAGSGAAPTFQTKLKHYKVFEGMPVTFACRVAGNPQPKIYWFKDGKQISPRSDHYTIHRDADGTCRLHAAASTLEDDGNYTVMAANPQVRQCGPAPSSGSGAHRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGRLCRMDCKVSGLPAPDLSWQLDGRPVRPDSAHRMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNAFSLELVVAAKEAHKPPVFLEKLQNTGVADGYPVRLECRVAAVPPPQIFWKKENESLTHSTDRVSMHQDNHGYVCLLIQGATRDDAGWYTVSAKNEAGIVSCTARLDVYTQWQQQPQSTKPKKVRPSASRYAALSDQGLDIRAAFQPEASPSPLTLNAALVESEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGK9</accession>
    <name>A0A8C5XGK9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier organic anion transporter family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">SLCO6A1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the organo anion transporter (TC 2.A.60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XGK9"/>
    <dbReference type="Ensembl" id="ENSMICT00000041439.2">
        <property type="protein sequence ID" value="ENSMICP00000020276.2"/>
        <property type="gene ID" value="ENSMICG00000000142.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286985"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015347">
        <property type="term" value="F:sodium-independent organic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043252">
        <property type="term" value="P:sodium-independent organic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000363">
        <property type="entry name" value="Solute carrier organic anion transporter family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004156">
        <property type="entry name" value="OATP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00805">
        <property type="entry name" value="oat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388">
        <property type="entry name" value="ORGANIC ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11388:SF95">
        <property type="entry name" value="SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 6A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03137">
        <property type="entry name" value="OATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="10">
        <location>
            <begin position="487"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020276.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="710" mass="78433" checksum="D3C1DE7E2C0CDD50" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XLG8</accession>
    <name>A0A8C5XLG8_MICMU</name>
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        <submittedName>
            <fullName evidence="7">Leucine rich repeat neuronal 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LRRN4</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021693">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XLG8"/>
    <dbReference type="Ensembl" id="ENSMICT00000040869.2">
        <property type="protein sequence ID" value="ENSMICP00000034879.2"/>
        <property type="gene ID" value="ENSMICG00000036616.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161448"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007616">
        <property type="term" value="P:long-term memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366">
        <property type="entry name" value="IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24366:SF13">
        <property type="entry name" value="LEUCINE-RICH REPEAT NEURONAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034990390" evidence="5">
        <location>
            <begin position="21"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="684"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="6">
        <location>
            <begin position="584"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="371"/>
            <end position="529"/>
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    </feature>
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        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
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        <location>
            <begin position="439"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034879.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="736" mass="77812" checksum="3630238093800016" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XLJ3</accession>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL39</fullName>
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        <alternativeName>
            <fullName evidence="8">39S ribosomal protein L39, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MRPL39</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL39 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000030050.2">
        <property type="protein sequence ID" value="ENSMICP00000034683.1"/>
        <property type="gene ID" value="ENSMICG00000006324.3"/>
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    <dbReference type="KEGG" id="mmur:105871208"/>
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    <dbReference type="OrthoDB" id="5870821at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
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    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000006">
        <property type="entry name" value="39S ribosomal protein L39, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
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        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="TGS" evidence="9">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00075914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="338" mass="38790" checksum="7D963E86962886C9" modified="2022-01-19" version="1">MEAMALGVRGLRLWRVAPGGRTGWRCIATSPASQLSPTELTEMRNDLFNKEKTRQLSLTPRTEKIEVKHVGKTDPGTIFVMNKNISTPYSCAMHLSEWYCKKSILALVDGQPWDMYKPLTKSCEIKFLTFKDDDPGEVNKAYWRSCAMMMGCVIERAFKDEYVVSLVRAPEVPVIAGAFCYDVVLDKRLDEWMPSKENLRSFTKDAHALIYKDLPFETLDVEAKVALEIFQHNKYKIDFIEEKASQNPERIVKLHRIGDFIDVSEGPLIPRTSICFQYEVSAVHNLQPTVPSLIRRFQGLSLPIHLRAHFTIWDKLLERSRKMVTEDQTKPTEENAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XM24</accession>
    <name>A0A8C5XM24_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lin-28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036045">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XM24"/>
    <dbReference type="Ensembl" id="ENSMICT00000045811.2">
        <property type="protein sequence ID" value="ENSMICP00000036636.2"/>
        <property type="gene ID" value="ENSMICG00000013694.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153295"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010587">
        <property type="term" value="P:miRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000632">
        <property type="term" value="P:negative regulation of pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031054">
        <property type="term" value="P:pre-miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000007">
        <property type="entry name" value="Protein lin-28 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000087">
        <property type="entry name" value="Protein lin-28 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051373">
        <property type="entry name" value="Lin-28_RNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054081">
        <property type="entry name" value="Lin-28A-like_Znf-CCHC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109">
        <property type="entry name" value="PROTEIN LIN-28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46109:SF2">
        <property type="entry name" value="PROTEIN LIN-28 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21890">
        <property type="entry name" value="Lin-28A-like_zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CSD" evidence="11">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036636.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="195" mass="21137" checksum="C2123B427D55ED6D" modified="2022-01-19" version="1">MGSVSNQQFAGGCAKAAEEAAEEAAEEAPEDAARPQLLHGAGICKWFNVRMGFGFLSVTARAGVLHMEGFRSLKEGEAVEFTFKKSAKGLESIRVTGPGGVFCIGSERRPKGKNMQKRRSKGDRCYNCGGLDQHAKECKLPPQPKKCHFCQSISHMVASCPLKAQQAPSAQGKPAYFREEEEEIHSPALLPEAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQE0</accession>
    <name>A0A8C5XQE0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major histocompatibility complex, class II, DO beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">HLA-DOB</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03007367">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03007368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQE0"/>
    <dbReference type="Ensembl" id="ENSMICT00000049926.2">
        <property type="protein sequence ID" value="ENSMICP00000039352.1"/>
        <property type="gene ID" value="ENSMICG00000034483.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162353"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023026">
        <property type="term" value="F:MHC class II protein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002587">
        <property type="term" value="P:negative regulation of antigen processing and presentation of peptide antigen via MHC class II"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom"/>
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    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000353">
        <property type="entry name" value="MHC_II_b_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF43">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DO BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00969">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00921">
        <property type="entry name" value="MHC_II_beta"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
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    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="120"/>
            <end position="158"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="256" mass="28440" checksum="027FB63DCB60E77D" modified="2022-01-19" version="1">MGSGWVPWAAALLVNPRRPDSSLRQGTDAPEDFVVQAKADCYFTNGTEKVQSVVRFIYNLEECARSDSDVGMAVAPRRWGSLTPSVGRGRAERSRAALGALCRPYYKQAPSLWGDRVMQPDMAVYPERAPLLQQHDLLLCSVTGFYPGDIKSRWFRNGHEERVGVMSAGLVRNGDWTFQTMVMLEMTPELGDSPASAQWTAQSDYPWRKMLSGVAAFQLGLIFWWGCSSASGLREVVCPEEHPAPTPTSHLQGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQH7</accession>
    <name>A0A8C5XQH7_MICMU</name>
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        <submittedName>
            <fullName evidence="3">Methyltransferase like 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">METTL25</name>
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    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03009364">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03009365">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000039553.1"/>
        <property type="gene ID" value="ENSMICG00000027175.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063745"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
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    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF9">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="272"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="721" mass="81956" checksum="07561EC317BE3995" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XR31</accession>
    <name>A0A8C5XR31_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PDZ domain containing 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">PDZD4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03035284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612648.1">
        <property type="nucleotide sequence ID" value="XM_012757194.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XR31"/>
    <dbReference type="Ensembl" id="ENSMICT00000036087.2">
        <property type="protein sequence ID" value="ENSMICP00000039789.1"/>
        <property type="gene ID" value="ENSMICG00000027183.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105867304"/>
    <dbReference type="CTD" id="57595"/>
    <dbReference type="GeneTree" id="ENSGT00950000183062"/>
    <dbReference type="OrthoDB" id="123971at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="CDD" id="cd06716">
        <property type="entry name" value="PDZ2-PDZRN4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000028">
        <property type="entry name" value="PDZ domain containing ring finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051971">
        <property type="entry name" value="E3_ubiquitin-PDZ_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545">
        <property type="entry name" value="PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15545:SF4">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="130"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="445"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="392"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="282"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="767" mass="86278" checksum="1AB4AC28468E9A14" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XRH7</accession>
    <name>A0A8C5XRH7_MICMU</name>
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        <submittedName>
            <fullName evidence="4">NTPase KAP family P-loop domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">NKPD1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XRH7"/>
    <dbReference type="Ensembl" id="ENSMICT00000051624.2">
        <property type="protein sequence ID" value="ENSMICP00000040157.2"/>
        <property type="gene ID" value="ENSMICG00000030601.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00650000093443"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011646">
        <property type="entry name" value="KAP_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052754">
        <property type="entry name" value="NTPase_KAP_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22674:SF4">
        <property type="entry name" value="NTPASE KAP FAMILY P-LOOP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22674">
        <property type="entry name" value="NTPASE, KAP FAMILY P-LOOP DOMAIN-CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07693">
        <property type="entry name" value="KAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="KAP NTPase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040157.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="599" mass="66084" checksum="DECDB08F04ACF005" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTE0</accession>
    <name>A0A8C5XTE0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TSPAN7</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in cell proliferation and cell motility.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03036427">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036428">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03036429">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592135.1">
        <property type="nucleotide sequence ID" value="XM_012736681.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTE0"/>
    <dbReference type="Ensembl" id="ENSMICT00000069503.1">
        <property type="protein sequence ID" value="ENSMICP00000041152.1"/>
        <property type="gene ID" value="ENSMICG00000011737.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855610"/>
    <dbReference type="KEGG" id="mmur:105855610"/>
    <dbReference type="CTD" id="7102"/>
    <dbReference type="GeneTree" id="ENSGT00940000156153"/>
    <dbReference type="OrthoDB" id="9972904at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03161">
        <property type="entry name" value="TM4SF2_6_like_LEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1450.10:FF:000003">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1450.10">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000301">
        <property type="entry name" value="Tetraspanin_animals"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048232">
        <property type="entry name" value="TSN6/7_LEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282">
        <property type="entry name" value="TETRASPANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19282:SF257">
        <property type="entry name" value="TETRASPANIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002419">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002419-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="249" mass="27559" checksum="C85B6E7A6DF9FF40" modified="2022-01-19" version="1">MASRRMETKPVITCLKTLLIIYSFVFWITGVILLAVGVWGKLTLGTYISLIAENSTNAPYVLIGTGTTIVVFGLFGCFATCRGSPWMLKLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTDAMQNYNGNDEKSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLSRFITANQYEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUV0</accession>
    <name>A0A8C5XUV0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03035356">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUV0"/>
    <dbReference type="Ensembl" id="ENSMICT00000060573.1">
        <property type="protein sequence ID" value="ENSMICP00000041657.1"/>
        <property type="gene ID" value="ENSMICG00000037905.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156106"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21433">
        <property type="entry name" value="SARAH_Sav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030030">
        <property type="entry name" value="Sav"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522:SF2">
        <property type="entry name" value="PROTEIN SALVADOR HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47522">
        <property type="entry name" value="SALVADOR FAMILY WW DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="332" mass="38355" checksum="F7A312276FC2C73C" modified="2022-01-19" version="1">MVPALTRKYKILRSHLKPAEVQGKFVKKETLTLLQNIMSSFIQHGPTISRRTDICLPDSSSNAFSASGDGKVSKNQKSNRLSEPSYRSRSLTDVPQEYGSSQSFFLFWHIMGSFLTEVNFAIENGDSDNFFDGQRRWPLGDRAHEDYRYYEYNHDLFQRMTQNQGRHPSGIGRVAATSLGNLTNHGSEDLPLPPGGHPLEQEGLSPRWERVESSEFGTYYVDHTNKAQYRHPCSPSISQYDQPPPVTYQPQQTERNQSLLVPENPYHTPEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLLKMYKAYRQALLSELENHKQRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XXB5</accession>
    <name>A0A8C5XXB5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Insulin-like peptide INSL6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">INSL6</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May have a role in sperm development and fertilization.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the insulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014368">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593323.1">
        <property type="nucleotide sequence ID" value="XM_012737869.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XXB5"/>
    <dbReference type="Ensembl" id="ENSMICT00000061675.1">
        <property type="protein sequence ID" value="ENSMICP00000042475.1"/>
        <property type="gene ID" value="ENSMICG00000044551.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105856301"/>
    <dbReference type="KEGG" id="mmur:105856301"/>
    <dbReference type="CTD" id="11172"/>
    <dbReference type="GeneTree" id="ENSGT00940000154434"/>
    <dbReference type="OrthoDB" id="9659760at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00101">
        <property type="entry name" value="IlGF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04365">
        <property type="entry name" value="IlGF_relaxin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.100.10">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022352">
        <property type="entry name" value="Ins/IGF/rlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016179">
        <property type="entry name" value="Insulin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017100">
        <property type="entry name" value="Insulin-like_pep_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036438">
        <property type="entry name" value="Insulin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022353">
        <property type="entry name" value="Insulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051042">
        <property type="entry name" value="Repro_Hormone_Insulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12004:SF1">
        <property type="entry name" value="INSULIN-LIKE PEPTIDE INSL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12004">
        <property type="entry name" value="RELAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00049">
        <property type="entry name" value="Insulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037062">
        <property type="entry name" value="Insulin-like_peptide_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00276">
        <property type="entry name" value="INSULINFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00078">
        <property type="entry name" value="IlGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56994">
        <property type="entry name" value="Insulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00262">
        <property type="entry name" value="INSULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0372">Hormone</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044049732" description="Insulin-like peptide INSL6" evidence="7">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Insulin-like" evidence="9">
        <location>
            <begin position="30"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="207" mass="24059" checksum="914E55FC209F7D2B" modified="2022-01-19" version="1">MSRLLCLCLLWLGLLMVRFSSELSDISIARRLCGRYLVREIVKLCGDADWSHVQFEEDIPLTQLLSETFMPDQFQSPQTFFPSWGRVTNPVATSVSREEAINSWEMHSLPRYHHKKVNSDKTRLFSSSQAINPYIDESVKFQKKSINKIKTLNNLFWGNHPQRKRRGYSEKCCLRGCTKEELSIACLPYINFKNLKEKGSSLVTEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZL0</accession>
    <name>A0A8C5XZL0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein eL21</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105854794</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012836">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012590815.1">
        <property type="nucleotide sequence ID" value="XM_012735361.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZL0"/>
    <dbReference type="SMR" id="A0A8C5XZL0"/>
    <dbReference type="Ensembl" id="ENSMICT00000062424.1">
        <property type="protein sequence ID" value="ENSMICP00000043674.1"/>
        <property type="gene ID" value="ENSMICG00000043664.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105854794"/>
    <dbReference type="KEGG" id="mmur:105854794"/>
    <dbReference type="KEGG" id="mmur:105880627"/>
    <dbReference type="GeneTree" id="ENSGT00950000182922"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="9511221at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="160" mass="18565" checksum="C51D0B5E8EB9D69E" modified="2022-01-19" version="1">MTNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKGMPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKSRDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELLEPIPYEFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZS0</accession>
    <name>A0A8C5XZS0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Olfactory receptor family 5 subfamily B member 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">OR5B21</name>
        <name evidence="10" type="synonym">LOC105863165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZS0"/>
    <dbReference type="Ensembl" id="ENSMICT00000060264.1">
        <property type="protein sequence ID" value="ENSMICP00000043746.1"/>
        <property type="gene ID" value="ENSMICG00000044902.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286921"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="261" mass="28554" checksum="45FCE4C2A222478F" modified="2022-01-19" version="1">MTPIFSNLSFVDLGYSSAVAPKMVAALPSGNKVISYNGCAAQFFFFVGFATVECYLLAPMAYDCRTAVCRPLHHTTAMTAGVHALPTSGSYVCGFLHASVPAADTFRLSFCASNEINHFFSVASPPLLALSCSDTHISKLVVFFVVGVNVFFTLLVILVSYIFRYIAIQRMRSAEAGKKAFSTCGSHLTTVSIFYGTIIFMYSQPSSGQSMDTVKIASVLYTVVTPMLNPLIYSLRNKGVKSSLWKMLNKLYLQSLNRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y103</accession>
    <name>A0A8C5Y103_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Protocadherin 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">PCDH10</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03018709">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018710">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y103"/>
    <dbReference type="Ensembl" id="ENSMICT00000061985.1">
        <property type="protein sequence ID" value="ENSMICP00000044267.1"/>
        <property type="gene ID" value="ENSMICG00000008070.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158277"/>
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        <property type="component" value="Chromosome 14"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y169</accession>
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            <taxon>Mammalia</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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    <sequence length="249" mass="28590" checksum="BB811C440675DF69" modified="2022-01-19" version="1">MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMTQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDISGLTDTTVPRCLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y175</accession>
    <name>A0A8C5Y175_MICMU</name>
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        <submittedName>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012601329.1">
        <property type="nucleotide sequence ID" value="XM_012745875.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5Y175"/>
    <dbReference type="Ensembl" id="ENSMICT00000065821.1">
        <property type="protein sequence ID" value="ENSMICP00000043838.1"/>
        <property type="gene ID" value="ENSMICG00000047334.1"/>
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    <dbReference type="GeneID" id="105860838"/>
    <dbReference type="CTD" id="400668"/>
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        <property type="component" value="Chromosome 24"/>
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        <property type="term" value="F:serine-type endopeptidase activity"/>
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        <property type="entry name" value="Tryp_SPc"/>
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        <property type="entry name" value="Trypsin-like serine proteases"/>
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        <property type="entry name" value="SERINE PROTEASE 57"/>
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        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CHYMOTRYPSIN"/>
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        <property type="entry name" value="TRYPSIN_HIS"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150432" evidence="7">
        <location>
            <begin position="29"/>
            <end position="280"/>
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    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="31"/>
            <end position="260"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50240"/>
        </source>
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    <evidence type="ECO:0000313" key="9">
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="280" mass="29865" checksum="49297D9DBE4FA750" modified="2022-01-19" version="1">MGTGVWGRLLLPVAAALTLHVKLPGSWGARIIGGREVVPHSRPYMASLRFGGQHHCGGFLLRAHWVVSAAHCLTHRDPRTGLVVLGSHALSAAEPTQQVFGIAAVVRHPDYHPTTHANDICLLRLNSSAVLGPAVGLLALPRRGTRPPKAGTRCRVAGWGFVSDFEELPPGLMEAEVRVLGLEICNSSWKGQLSPAMLCTHSGDRQRRGFCSADSGGPLVCRNRAHGLVSFSGLWCGDPKTPDVYTQVSAFVAWIWDVVQRGSPQPSPVPGTSRPPAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y2U4</accession>
    <name>A0A8C5Y2U4_MICMU</name>
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        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 2 subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Eukaryotic translation initiation factor 2 subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">EIF2S1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Stress granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004026">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y2U4"/>
    <dbReference type="Ensembl" id="ENSMICT00000070408.1">
        <property type="protein sequence ID" value="ENSMICP00000044673.1"/>
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    <dbReference type="GeneTree" id="ENSGT00390000007015"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:HRI-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032057">
        <property type="term" value="P:negative regulation of translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036499">
        <property type="term" value="P:PERK-mediated unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036490">
        <property type="term" value="P:regulation of translation in response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043558">
        <property type="term" value="P:regulation of translational initiation in response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="36011" checksum="9CA517C5D66748EA" modified="2022-01-19" version="1">MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3T7</accession>
    <name>A0A8C5Y3T7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endothelin-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Preproendothelin-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">EDN3</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Endothelins are endothelium-derived vasoconstrictor peptides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the endothelin/sarafotoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021964">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y3T7"/>
    <dbReference type="Ensembl" id="ENSMICT00000058739.1">
        <property type="protein sequence ID" value="ENSMICP00000045481.1"/>
        <property type="gene ID" value="ENSMICG00000042154.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183053"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031708">
        <property type="term" value="F:endothelin B receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048675">
        <property type="term" value="P:axon extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030593">
        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030072">
        <property type="term" value="P:peptide hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045597">
        <property type="term" value="P:positive regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010460">
        <property type="term" value="P:positive regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046887">
        <property type="term" value="P:positive regulation of hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002690">
        <property type="term" value="P:positive regulation of leukocyte chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901381">
        <property type="term" value="P:positive regulation of potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071805">
        <property type="term" value="P:potassium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048070">
        <property type="term" value="P:regulation of developmental pigmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003100">
        <property type="term" value="P:regulation of systemic arterial blood pressure by endothelin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019229">
        <property type="term" value="P:regulation of vasoconstriction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014826">
        <property type="term" value="P:vein smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020475">
        <property type="entry name" value="Endothelin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019764">
        <property type="entry name" value="Endothelin_toxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001928">
        <property type="entry name" value="Endothln-like_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13874:SF11">
        <property type="entry name" value="ENDOTHELIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00322">
        <property type="entry name" value="Endothelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00365">
        <property type="entry name" value="ENDOTHELIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00272">
        <property type="entry name" value="END"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00270">
        <property type="entry name" value="ENDOTHELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0838">Vasoactive</keyword>
    <keyword evidence="9" id="KW-0839">Vasoconstrictor</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034735067" description="Endothelin-3" evidence="13">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="14">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Endothelin-like toxin" evidence="14">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="175"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="222" mass="24276" checksum="49DF47EF7BF7C0C5" modified="2022-01-19" version="1">MEPGLWLLFGLTVTSAAAAGFVPPQPGDAGRSGVLQVPPAATSEGDLEETRAGLRGWTVAPVIAVQGPSPGQEEQEAEEGPEHHRSRRCTCFTYKDKECVYYCHLDIIWINTPEQTVPYGLSNYRGSFRGKRSVGPLWGSWQPSKQTPLRCACVGRDDKACVHFCSQTLDISSHSRTAERPDKEEEEKARGALDLHHPKLMPSSGRHCRSPARPAAFLEGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YCN3</accession>
    <name>A0A8C5YCN3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3 5">MOB kinase activator 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">MOB1B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOB1/phocein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029030">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012641381.1">
        <property type="nucleotide sequence ID" value="XM_012785927.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YCN3"/>
    <dbReference type="SMR" id="A0A8C5YCN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000058874.1">
        <property type="protein sequence ID" value="ENSMICP00000049669.1"/>
        <property type="gene ID" value="ENSMICG00000041994.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105883059"/>
    <dbReference type="KEGG" id="mmur:105883059"/>
    <dbReference type="CTD" id="92597"/>
    <dbReference type="GeneTree" id="ENSGT01120000271863"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.30:FF:000001">
        <property type="entry name" value="MOB kinase activator 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012641381.1"/>
        </source>
    </evidence>
    <sequence length="216" mass="25091" checksum="29EBA287B0CDAF90" modified="2022-01-19" version="1">MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YDW5</accession>
    <name>A0A8C5YDW5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LOC105862173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03009456">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YDW5"/>
    <dbReference type="Ensembl" id="ENSMICT00000061745.1">
        <property type="protein sequence ID" value="ENSMICP00000050322.1"/>
        <property type="gene ID" value="ENSMICG00000047373.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157918"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008352">
        <property type="term" value="C:katanin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845">
        <property type="entry name" value="KATANIN P80 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845:SF0">
        <property type="entry name" value="KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="16"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="198" mass="21059" checksum="85DECA06583EB37F" modified="2022-01-19" version="1">MATPVVTKTAWKLQEIVAHAGNVSSLVLGKASGRLLATGGDDCRANLWSISKPNCIMSLTGHTSPVESVRLNTPEELIVDGSQSGSSRVWDLEAVVSCMEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVFSSVVDLTQVTRTSTVAQDSVQDSRPLPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFN9</accession>
    <name>A0A8C5YFN9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NLR family pyrin domain containing 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">LOC105877211</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NLRP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026643">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026644">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000063459.1">
        <property type="protein sequence ID" value="ENSMICP00000050110.1"/>
        <property type="gene ID" value="ENSMICG00000042592.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161714"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050727">
        <property type="term" value="P:regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08320">
        <property type="entry name" value="Pyrin_NALPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001341">
        <property type="entry name" value="NLR family pyrin domain containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.10">
        <property type="entry name" value="Death Domain, Fas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004020">
        <property type="entry name" value="DAPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011029">
        <property type="entry name" value="DEATH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050637">
        <property type="entry name" value="NLRP_innate_immun_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041075">
        <property type="entry name" value="NOD1/2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45690:SF14">
        <property type="entry name" value="NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02758">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17779">
        <property type="entry name" value="WHD_NOD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM01289">
        <property type="entry name" value="PYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47986">
        <property type="entry name" value="DEATH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50824">
        <property type="entry name" value="DAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pyrin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="7">
        <location>
            <begin position="172"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1038" mass="117449" checksum="7A9274AA0F59C14D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EFR7</accession>
    <name>A0A8C6EFR7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tumor necrosis factor receptor superfamily member 13B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Transmembrane activator and CAML interactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">TNFRSF13B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of CAMLG with its C-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020698">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EFR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000069577.1">
        <property type="protein sequence ID" value="ENSMICP00000040620.1"/>
        <property type="gene ID" value="ENSMICG00000041511.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013910"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002244">
        <property type="term" value="P:hematopoietic progenitor cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030889">
        <property type="term" value="P:negative regulation of B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13415">
        <property type="entry name" value="TNFRSF13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1290.10:FF:000001">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily member 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1290.10:FF:000002">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily member 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1290.10">
        <property type="entry name" value="Tumor necrosis factor receptor superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015384">
        <property type="entry name" value="TACI_Cys-rich-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022317">
        <property type="entry name" value="TNFR_13B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15511">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15511:SF2">
        <property type="entry name" value="TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 13B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09305">
        <property type="entry name" value="TACI-CRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01963">
        <property type="entry name" value="TNFACTORR13B"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57586">
        <property type="entry name" value="TNF receptor-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="TACI cysteine-rich" evidence="17">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="221"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00058588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF09305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="308" mass="33515" checksum="4EB834C91E449A16" modified="2022-01-19" version="1">MQSHKRRFIFWLARVQAPEHQHSGHSRRQGPRPEQQHAFYPHAPQGLRTADRVAMGPCPKEQYWEPLLHRCISCKSTCNHRNQHTCTAFCKSLSCRKEQGKYYDYLLRDCISCISTCGQHPKQCAYFCENKLRSRVNFPPALRRQQSEEAETRSDNSGRYQASEHRGSEAGPAPPGPKLSADQLALAYSTLGLCLCAIFCCFLVAMACFLKRRRDQVSCQPPAGPCGSPAKSSQDDAMEAGSPTGAAPEPVETCSFCFPERRAPTQESAGAPGTPGLAGTAALQPCARASDGCLGVVCAPAKEGGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKL5</accession>
    <name>A0A8C6EKL5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Ephrin type-A receptor 3</fullName>
            <ecNumber evidence="2">2.7.10.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">EPH-like kinase 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Tyrosine-protein kinase TYRO4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">EPHA3</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.10.1" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03032806">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032807">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKL5"/>
    <dbReference type="Ensembl" id="ENSMICT00000066418.1">
        <property type="protein sequence ID" value="ENSMICP00000049395.1"/>
        <property type="gene ID" value="ENSMICG00000005266.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157088"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005005">
        <property type="term" value="F:transmembrane-ephrin receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05066">
        <property type="entry name" value="PTKc_EphR_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09544">
        <property type="entry name" value="SAM_EPH-A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000046">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000041">
        <property type="entry name" value="ephrin type-A receptor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000019">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.10:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000045">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1770:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000001">
        <property type="entry name" value="Ephrin type-A receptor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1770">
        <property type="entry name" value="ephrin a2 ectodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027936">
        <property type="entry name" value="Eph_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001090">
        <property type="entry name" value="Ephrin_rcpt_lig-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050449">
        <property type="entry name" value="Ephrin_rcpt_TKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016257">
        <property type="entry name" value="Tyr_kinase_ephrin_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001426">
        <property type="entry name" value="Tyr_kinase_rcpt_V_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877">
        <property type="entry name" value="EPH RECEPTOR A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46877:SF12">
        <property type="entry name" value="EPHRIN TYPE-A RECEPTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14575">
        <property type="entry name" value="EphA2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25599">
        <property type="entry name" value="Ephrin_CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01404">
        <property type="entry name" value="Ephrin_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000666">
        <property type="entry name" value="TyrPK_ephrin_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00014">
        <property type="entry name" value="FNTYPEIII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00615">
        <property type="entry name" value="EPH_lbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51550">
        <property type="entry name" value="EPH_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00790">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00791">
        <property type="entry name" value="RECEPTOR_TYR_KIN_V_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 23 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 23 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Eph LBD" evidence="30">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="252"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="29">
        <location>
            <begin position="363"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="27">
        <location>
            <begin position="549"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="28">
        <location>
            <begin position="839"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="22">
        <location>
            <position position="674"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <begin position="555"/>
            <end position="563"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23 25">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="24">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00057586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00072205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000666-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="911" mass="102052" checksum="6F0E4B14EA9E93FE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EL80</accession>
    <name>A0A8C6EL80_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c</fullName>
        </recommendedName>
    </protein>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 17">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="17">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014737">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EL80"/>
    <dbReference type="Ensembl" id="ENSMICT00000058424.1">
        <property type="protein sequence ID" value="ENSMICP00000050008.1"/>
        <property type="gene ID" value="ENSMICG00000043882.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009405"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000008">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15 17" id="KW-0349">Heme</keyword>
    <keyword evidence="12 15 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="18">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="105" mass="11649" checksum="B12A7C109CFF0522" modified="2022-01-19" version="1">MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSYTDANKNKAITWGEDTLMEYLENPKKYIPGTKMIFTGIKKKGERADLIAYLKKATNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ECI6</accession>
    <name>A0A8B7ECI6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="32">Cytochrome P450 1A</fullName>
            <ecNumber evidence="32">1.14.14.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33 35" type="primary">CYP1A1</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="33" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="32">Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate = 12-oxo-(5Z,8Z,10E,14Z)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:37947"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57444"/>
            <dbReference type="ChEBI" id="CHEBI:75231"/>
            <dbReference type="EC" id="4.2.1.152"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:37948"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57466"/>
            <dbReference type="ChEBI" id="CHEBI:90781"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:48717"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48636"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57410"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48637"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52120"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:136410"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:52121"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:48632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57450"/>
            <dbReference type="ChEBI" id="CHEBI:65342"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:48633"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49860"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:131965"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="29">
            <dbReference type="Rhea" id="RHEA:49861"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49856"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:131964"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:49857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39759"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:76627"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:39760"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + reduced [NADPH--hemoprotein reductase] + O2 = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39779"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58562"/>
            <dbReference type="ChEBI" id="CHEBI:76634"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:39780"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47212"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:28744"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:47213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxy-17beta-estradiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47280"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16469"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:62845"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:47281"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>all-trans-retinal + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-retinoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42088"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:42089"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>all-trans-retinol + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-retinal + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42092"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:42093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>estrone + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47208"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:1156"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:47209"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>estrone + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxyestrone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:47292"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17263"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:87602"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:47293"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 30 32">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor metabolism; retinol metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="32">Endoplasmic reticulum membrane</location>
            <topology evidence="32">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="32">Microsome membrane</location>
            <topology evidence="32">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 31">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.1" evidence="32"/>
    <dbReference type="EMBL" id="ABDC03004905">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ECI6"/>
    <dbReference type="Ensembl" id="ENSMICT00000048712.2">
        <property type="protein sequence ID" value="ENSMICP00000033975.1"/>
        <property type="gene ID" value="ENSMICG00000009669.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105854864"/>
    <dbReference type="KEGG" id="mmur:105854864"/>
    <dbReference type="CTD" id="1543"/>
    <dbReference type="VGNC" id="VGNC:80533">
        <property type="gene designation" value="CYP1A1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183037"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="UniPathway" id="UPA00912"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008391">
        <property type="term" value="F:arachidonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101020">
        <property type="term" value="F:estrogen 16-alpha-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101021">
        <property type="term" value="F:estrogen 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106256">
        <property type="term" value="F:hydroperoxy icosatetraenoate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120319">
        <property type="term" value="F:long-chain fatty acid omega-1 hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102033">
        <property type="term" value="F:long-chain fatty acid omega-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070576">
        <property type="term" value="F:vitamin D 24-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008210">
        <property type="term" value="P:estrogen metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042446">
        <property type="term" value="P:hormone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050665">
        <property type="term" value="P:hydrogen peroxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002933">
        <property type="term" value="P:lipid hydroxylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001676">
        <property type="term" value="P:long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042572">
        <property type="term" value="P:retinol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009404">
        <property type="term" value="P:toxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042359">
        <property type="term" value="P:vitamin D metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006805">
        <property type="term" value="P:xenobiotic metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20676">
        <property type="entry name" value="CYP1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000002">
        <property type="entry name" value="Cytochrome P450 1A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008066">
        <property type="entry name" value="Cyt_P450_E_grp-I_CYP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF21">
        <property type="entry name" value="CYTOCHROME P450 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01683">
        <property type="entry name" value="EP450ICYP1A"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 32" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 30 31" id="KW-0349">Heme</keyword>
    <keyword evidence="14 30 31" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 30 31" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 32" id="KW-0492">Microsome</keyword>
    <keyword evidence="15 31" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="13 31" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="30">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004891"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049064"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049384"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU368045"/>
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    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033975.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
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        <source>
            <dbReference type="VGNC" id="VGNC:80533"/>
        </source>
    </evidence>
    <sequence length="516" mass="58449" checksum="551D3291C98F96FD" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDB1</accession>
    <name>A0A8B7EDB1_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">ATP-binding cassette sub-family F member 3</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="primary">ABCF3</name>
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    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
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        <property type="nucleotide sequence ID" value="XM_012736920.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000050688.1"/>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_tran_Xtn"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
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    </dbReference>
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        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
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        <property type="entry name" value="ABC_tran_Xtn"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF26051">
        <property type="entry name" value="PWI_ABCF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="178"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="492"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="709" mass="79639" checksum="10B7084FEA7F15ED" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EF68</accession>
    <name>A0A8B7EF68_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ectonucleotide pyrophosphatase/phosphodiesterase family member 3</fullName>
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            <ecNumber evidence="20">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="30">Alkaline phosphodiesterase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Dinucleoside polyphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Nucleotide diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Nucleotide pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Phosphodiesterase I beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Phosphodiesterase I/nucleotide pyrophosphatase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="41" type="primary">ENPP3</name>
    </gene>
    <organism evidence="41 42">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="41" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="41" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="41" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="31">Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation. Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>ATP + H2O = AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:14246"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>CTP + H2O = CMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27762"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:27763"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="35">
            <text>GTP + H2O = GMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29391"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="35">
            <dbReference type="Rhea" id="RHEA:29392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="34">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="34">
            <dbReference type="Rhea" id="RHEA:13894"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="37">
            <text>P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32039"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="37">
            <dbReference type="Rhea" id="RHEA:32040"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="33">
            <text>P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = GMP + GTP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:22484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57553"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="38">
            <text>P(1),P(5)-bis(5'-adenosyl) pentaphosphate + H2O = adenosine 5'-tetraphosphate + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58450"/>
            <dbReference type="ChEBI" id="CHEBI:62041"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="38">
            <dbReference type="Rhea" id="RHEA:32052"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="36">
            <text>UDP-N-acetyl-alpha-D-glucosamine + H2O = N-acetyl-alpha-D-glucosamine 1-phosphate + UMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29547"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="36">
            <dbReference type="Rhea" id="RHEA:29548"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="32">
            <text>UTP + H2O = UMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="32">
            <dbReference type="Rhea" id="RHEA:29396"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:23997"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Apical cell membrane</location>
            <topology evidence="4">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="6"/>
    <dbReference type="EC" id="3.6.1.9" evidence="20"/>
    <dbReference type="EMBL" id="ABDC03008416">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592077.1">
        <property type="nucleotide sequence ID" value="XM_012736623.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EF68"/>
    <dbReference type="Ensembl" id="ENSMICT00000029999.2">
        <property type="protein sequence ID" value="ENSMICP00000024320.1"/>
        <property type="gene ID" value="ENSMICG00000002944.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855552"/>
    <dbReference type="KEGG" id="mmur:105855552"/>
    <dbReference type="CTD" id="5169"/>
    <dbReference type="GeneTree" id="ENSGT00940000159640"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106177">
        <property type="term" value="F:cyclic-GMP-AMP hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002276">
        <property type="term" value="P:basophil activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160049">
        <property type="term" value="P:negative regulation of cGAS/STING signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033007">
        <property type="term" value="P:negative regulation of mast cell activation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070667">
        <property type="term" value="P:negative regulation of mast cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055062">
        <property type="term" value="P:phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000010">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.20:FF:000001">
        <property type="entry name" value="Ectonucleotide pyrophosphatase/phosphodiesterase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000005">
        <property type="entry name" value="ectonucleotide pyrophosphatase/phosphodiesterase family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.20:FF:000004">
        <property type="entry name" value="ectonucleotide pyrophosphatase/phosphodiesterase family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036024">
        <property type="entry name" value="Somatomedin_B-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001212">
        <property type="entry name" value="Somatomedin_B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF107">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE_PHOSPHODIESTERASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01033">
        <property type="entry name" value="Somatomedin_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00201">
        <property type="entry name" value="SO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90188">
        <property type="entry name" value="Somatomedin B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00524">
        <property type="entry name" value="SMB_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50958">
        <property type="entry name" value="SMB_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 39" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 39" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 39" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="39">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="40">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="SMB" evidence="40">
        <location>
            <begin position="94"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00038862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00041154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00041699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044879"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044894"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00044922"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="PROSITE" id="PS50958"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024320.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="874" mass="99430" checksum="306283251FDD0EA7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EGT1</accession>
    <name>A0A8B7EGT1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HEATR1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Ribosome biogenesis factor; required for recruitment of Myc to nucleoli. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in neuronal-lineage cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the small subunit (SSU) processome, composed of more than 70 proteins and the RNA chaperone small nucleolar RNA (snoRNA) U3. Interacts with MYC; the interaction is required for localization of MYC to the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
            <location evidence="1 13">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021287">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593749.1">
        <property type="nucleotide sequence ID" value="XM_012738295.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000015895.3">
        <property type="protein sequence ID" value="ENSMICP00000014488.2"/>
        <property type="gene ID" value="ENSMICG00000015859.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856497"/>
    <dbReference type="KEGG" id="mmur:105856497"/>
    <dbReference type="CTD" id="55127"/>
    <dbReference type="GeneTree" id="ENSGT00390000015845"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061351">
        <property type="term" value="P:neural precursor cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000534">
        <property type="entry name" value="HEAT repeat containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 13" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 13" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="14">
        <location>
            <begin position="1856"/>
            <end position="2009"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014488.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2143" mass="242765" checksum="E6A9B00247682F43" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQP9</accession>
    <name>A0A8B7EQP9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Lymphotoxin-alpha</fullName>
            <shortName evidence="12">LT-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 12">TNF-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Tumor necrosis factor ligand superfamily member 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LTA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10 12">Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the tumor necrosis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596518.1">
        <property type="nucleotide sequence ID" value="XM_012741064.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQP9"/>
    <dbReference type="Ensembl" id="ENSMICT00000045213.2">
        <property type="protein sequence ID" value="ENSMICP00000019821.1"/>
        <property type="gene ID" value="ENSMICG00000036584.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858138"/>
    <dbReference type="KEGG" id="mmur:105858138"/>
    <dbReference type="CTD" id="4049"/>
    <dbReference type="GeneTree" id="ENSGT01060000248544"/>
    <dbReference type="OrthoDB" id="9940698at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005164">
        <property type="term" value="F:tumor necrosis factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050830">
        <property type="term" value="P:defense response to Gram-positive bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006959">
        <property type="term" value="P:humoral immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048535">
        <property type="term" value="P:lymph node development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002876">
        <property type="term" value="P:positive regulation of chronic inflammatory response to antigenic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001238">
        <property type="term" value="P:positive regulation of extrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002925">
        <property type="term" value="P:positive regulation of humoral immune response mediated by circulating immunoglobulin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032729">
        <property type="term" value="P:positive regulation of type II interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00184">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.40:FF:000016">
        <property type="entry name" value="Tumor necrosis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006053">
        <property type="entry name" value="TNF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002960">
        <property type="entry name" value="TNF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021184">
        <property type="entry name" value="TNF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006052">
        <property type="entry name" value="TNF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471:SF31">
        <property type="entry name" value="LYMPHOTOXIN-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11471">
        <property type="entry name" value="TUMOR NECROSIS FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00229">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01234">
        <property type="entry name" value="TNECROSISFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01236">
        <property type="entry name" value="TNFBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00207">
        <property type="entry name" value="TNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00251">
        <property type="entry name" value="THD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50049">
        <property type="entry name" value="THD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7 12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 12 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133411" description="Lymphotoxin-alpha" evidence="13">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="THD" evidence="14">
        <location>
            <begin position="63"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="205" mass="22225" checksum="FC61DAEF0C83BF43" modified="2022-01-19" version="1">MTPPGRLYLPRVHGTPLHLLLLVLLLALLPATQELPGVGLAPPAAQTAHQHPQKHFTHSTLKPAAHLIGDPSKQDSLRWRANTDRAFLQHGFSLSNNSLLVPASGIYFVYSQVVFSGQACPPEATPTPLYLAHEVQLFSSQYPFHVPLLSAQKTVCPGPQGPWLHSMYHGAAFLLTQGDQLSTHTDGIPHLLLSPSSVFFGAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQX7</accession>
    <name>A0A8B7EQX7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DDB1- and CUL4-associated factor 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat-containing protein 21A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">DCAF4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with DDB1 and CUL4A.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003856">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596595.1">
        <property type="nucleotide sequence ID" value="XM_012741141.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596602.1">
        <property type="nucleotide sequence ID" value="XM_012741148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQX7"/>
    <dbReference type="Ensembl" id="ENSMICT00000029207.2">
        <property type="protein sequence ID" value="ENSMICP00000027788.2"/>
        <property type="gene ID" value="ENSMICG00000015497.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000062883.1">
        <property type="protein sequence ID" value="ENSMICP00000048134.1"/>
        <property type="gene ID" value="ENSMICG00000015497.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858170"/>
    <dbReference type="KEGG" id="mmur:105858170"/>
    <dbReference type="CTD" id="26094"/>
    <dbReference type="GeneTree" id="ENSGT00390000009546"/>
    <dbReference type="OrthoDB" id="128867at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000494">
        <property type="entry name" value="DDB1- and CUL4-associated factor 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052254">
        <property type="entry name" value="CUL4-DDB1_E3_ligase_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472:SF1">
        <property type="entry name" value="DDB1 AND CUL4 ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44472">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23761">
        <property type="entry name" value="Beta-prop_DCAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="370"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="496" mass="55679" checksum="72B57ABB9A4E7F90" modified="2022-01-19" version="1">MSKNSWPSRRRHGRRLYQRNPWFRLRDSNERYDPGALQSTQDSGSGDDESPSTSSGVAGSSSVPDLPGYYFDPEKKRYFRLLPGHNNCNPLTNESIRQKEMEKKRLQLLEEEDKQKKKIARLGFNASSMLRKNQLGFLNVTSYCRLAHELRVSCMQRNKVQIHSSDPSALASDRFNLILADTNSDRLFTVNDVKVGGSKYGIINLRGLKTPSLRVHMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVSSHPGVDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLLTNVVTGHRQSFVTSSDVLTQQFALLAPLLFNGCRSGEIFAIDLRCGNQGKGWKATRLFHDSAVTSVQILQEEECVMASDMAGKIKLWDLRAMKCIRQYEGHVNEYAYLPLHVHEEEGIVVAVGQDCYTRIWSFHDAQLLRTIPSPYPTSKADIPSVAFSSRLGGFRGAPGLLMAVQRDLYCFSYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EUS9</accession>
    <name>A0A8B7EUS9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease III-like protein 1</fullName>
            <ecNumber evidence="15">3.2.2.-</ecNumber>
            <ecNumber evidence="15">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="15">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15 18" type="primary">NTHL1</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with YBX1. Interacts with ERCC5/XPG; the interaction stimulates NTHL1 activity and NTHL1 binding to its DNA substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="15"/>
    <dbReference type="EC" id="4.2.99.18" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03020800">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598990.1">
        <property type="nucleotide sequence ID" value="XM_012743536.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EUS9"/>
    <dbReference type="Ensembl" id="ENSMICT00000032554.2">
        <property type="protein sequence ID" value="ENSMICP00000033675.1"/>
        <property type="gene ID" value="ENSMICG00000035043.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105859604"/>
    <dbReference type="CTD" id="4913"/>
    <dbReference type="GeneTree" id="ENSGT00510000047513"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HhH-GPD" evidence="17">
        <location>
            <begin position="138"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="312" mass="34431" checksum="91FA9444589A518B" modified="2022-01-19" version="1">MCSPQESGMNAMSTRMVTRSRTRGPGARPRAGGEDSAPLGKGEAAAEGRKRHSPVKRQQKPQRLHVAYEASDGEKGEGSEPFKVPTWEPQDWQQQLVNIRTMRSKKDAPVDQLGAEHCYDASAPPKVRRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDSTLGKLIYPVGFWRNKVKYIKQTSAILQQRYGGDIPASVPELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRITNRLRWTKKPTKSPEETRVALEEWLPRELWSEINGLLVGFGQQTCLPVHPRCQACLNQSLCPAARGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EZT2</accession>
    <name>A0A8B7EZT2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GINS1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021451">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012600983.1">
        <property type="nucleotide sequence ID" value="XM_012745529.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EZT2"/>
    <dbReference type="Ensembl" id="ENSMICT00000035292.2">
        <property type="protein sequence ID" value="ENSMICP00000029384.1"/>
        <property type="gene ID" value="ENSMICG00000037715.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860645"/>
    <dbReference type="CTD" id="9837"/>
    <dbReference type="GeneTree" id="ENSGT00390000013968"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001833">
        <property type="term" value="P:inner cell mass cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="11">
        <location>
            <begin position="42"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="12">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="196" mass="22985" checksum="340BB4169F09C28A" modified="2022-01-19" version="1">MFCEKAMELVRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIPTIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMSAEEMEWFNHYKKSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSILLKKNSQHFLPRWKCEQLIRQGVLEHVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F5Q6</accession>
    <name>A0A8B7F5Q6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein axonemal intermediate chain 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">WD repeat-containing protein 63</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">DNAI3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Acts as a negative regulator of cell migration, invasion, and metastasis downstream of p53/TP53, through inhibition of Arp2/3 complex-mediated actin polymerization. Via its association with the multisubunit axonemal dynein complex, is potentially involved in the regulation of cilia function. May play a role in osteogenesis of dental tissue-derived mesenchymal stem cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with ACTR2; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors. Part of the multisubunit axonemal dynein complex formed at least of two heavy chains and a number of intermediate and light chains. Found in a associated with the catalytic heavy chain DNAH2, the intermediate chain DNAI4, and the light chain DYNLT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03002715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603064.1">
        <property type="nucleotide sequence ID" value="XM_012747610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F5Q6"/>
    <dbReference type="Ensembl" id="ENSMICT00000015010.3">
        <property type="protein sequence ID" value="ENSMICP00000013687.3"/>
        <property type="gene ID" value="ENSMICG00000014988.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861807"/>
    <dbReference type="KEGG" id="mmur:105861807"/>
    <dbReference type="CTD" id="126820"/>
    <dbReference type="GeneTree" id="ENSGT00940000156924"/>
    <dbReference type="OrthoDB" id="6619788at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060294">
        <property type="term" value="P:cilium movement involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030336">
        <property type="term" value="P:negative regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045669">
        <property type="term" value="P:positive regulation of osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000415">
        <property type="entry name" value="WD repeat domain 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF5">
        <property type="entry name" value="DYNEIN AXONEMAL INTERMEDIATE CHAIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="823"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013687.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="893" mass="103116" checksum="D3409FBFC34270E2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FBP9</accession>
    <name>A0A8B7FBP9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sidoreflexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SFXN5</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the sideroflexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005124">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605580.1">
        <property type="nucleotide sequence ID" value="XM_012750126.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FBP9"/>
    <dbReference type="Ensembl" id="ENSMICT00000011289.3">
        <property type="protein sequence ID" value="ENSMICP00000010281.2"/>
        <property type="gene ID" value="ENSMICG00000011287.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863242"/>
    <dbReference type="KEGG" id="mmur:105863242"/>
    <dbReference type="CTD" id="94097"/>
    <dbReference type="GeneTree" id="ENSGT01030000234641"/>
    <dbReference type="OrthoDB" id="6608471at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015075">
        <property type="term" value="F:monoatomic ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004686">
        <property type="entry name" value="Mtc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00798">
        <property type="entry name" value="mtc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153">
        <property type="entry name" value="SIDEROFLEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11153:SF17">
        <property type="entry name" value="SIDEROFLEXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03820">
        <property type="entry name" value="SFXNs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010281.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="340" mass="37122" checksum="E7A6A550E57FE723" modified="2022-01-19" version="1">MADTATTASAAAASAASASTDAPPFQLGKPRFQQTSFYGRFRHFLDIIDPRTLFVTERRLREAVQLLEDYKHGTLRPGVTNEQLWSAQKIKQAILHPDTNEKIFMPFRMSGYIPFGTPIVVGLLLPNQTLASTVFWQWLNQSHNACVNYANRNATKPSPASKFIQGYLGAVISAVSIAVGLNVLVQKANKFTPATRLLVQRFVPFPAVASANICNVVLMRYGELEEGIDVLDGDGNLVGSSKIAARHALLETALTRVVLPMPILVLPPIVMSMLEKTALLQARPRLLLPVQSLVCLAAFGLALPLAISLFPQMSEIETSQLEPEIARATSSRTVVYNKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FBW9</accession>
    <name>A0A8B7FBW9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 26B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">CYP26B1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-18-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:55856"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:139258"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:55857"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51984"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35291"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:134178"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:51985"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605655.1">
        <property type="nucleotide sequence ID" value="XM_012750201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FBW9"/>
    <dbReference type="Ensembl" id="ENSMICT00000037241.2">
        <property type="protein sequence ID" value="ENSMICP00000038490.1"/>
        <property type="gene ID" value="ENSMICG00000016464.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863279"/>
    <dbReference type="KEGG" id="mmur:105863279"/>
    <dbReference type="CTD" id="56603"/>
    <dbReference type="VGNC" id="VGNC:80508">
        <property type="gene designation" value="CYP26B1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00800000124060"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008401">
        <property type="term" value="F:retinoic acid 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001972">
        <property type="term" value="F:retinoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060349">
        <property type="term" value="P:bone morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001709">
        <property type="term" value="P:cell fate determination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071300">
        <property type="term" value="P:cellular response to retinoic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070268">
        <property type="term" value="P:cornification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030326">
        <property type="term" value="P:embryonic limb morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001768">
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                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="1512" mass="161888" checksum="7712ACCABB8B9A35" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FJG3</accession>
    <name>A0A8B7FJG3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Calcium homeostasis modulator family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CALHM4</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CALHM family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008250">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608723.1">
        <property type="nucleotide sequence ID" value="XM_012753269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FJG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000039597.2">
        <property type="protein sequence ID" value="ENSMICP00000032261.1"/>
        <property type="gene ID" value="ENSMICG00000008123.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864996"/>
    <dbReference type="KEGG" id="mmur:105864996"/>
    <dbReference type="CTD" id="221301"/>
    <dbReference type="GeneTree" id="ENSGT01030000234610"/>
    <dbReference type="OrthoDB" id="9827748at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904669">
        <property type="term" value="P:ATP export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029569">
        <property type="entry name" value="CALHM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32261:SF5">
        <property type="entry name" value="CALCIUM HOMEOSTASIS MODULATOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14798">
        <property type="entry name" value="Ca_hom_mod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="35457" checksum="0EA43964749CA018" modified="2022-01-19" version="1">MSPALQNIMSSLQRSGTLINSLIAALTAGGQQLFSCFTFRCPCQVGKNFYYGSAFLIIPALILLIAGYALRSQMWTMTGEYCCSCVPPHRRISPLERKLACLRFFSITGRAVVAPLTWLAATLLTGTYYECAASEFATVDNYPVFDNVSASKREEILAEFPCFRSAPSDLIPVRDEIVLLHRYQSQMLGWILITLATIAILVSYSLARCCSPLTSLQDYYWNNHLQNERKLFEEAAEQHSRLLIMQRIKKLFGFIPGSEDVKQIRIPSCQDWREISAPSLLCMGDYLQGHYSFLGDRVDEDNEEDKSRGIELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FPS4</accession>
    <name>A0A8B7FPS4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">COX4I2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021645">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610684.1">
        <property type="nucleotide sequence ID" value="XM_012755230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FPS4"/>
    <dbReference type="Ensembl" id="ENSMICT00000046415.2">
        <property type="protein sequence ID" value="ENSMICP00000033252.1"/>
        <property type="gene ID" value="ENSMICG00000030241.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105866063"/>
    <dbReference type="KEGG" id="mmur:105866063"/>
    <dbReference type="GeneTree" id="ENSGT00390000002407"/>
    <dbReference type="OrthoDB" id="186013at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 4 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013288">
        <property type="entry name" value="Cyt_c_oxidase_su4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4 ISOFORM 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01873">
        <property type="entry name" value="CYTCOXIDASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="171" mass="20214" checksum="BCA5330DD470A1B0" modified="2022-01-19" version="1">MLSRAAWSLVLRRGGPGTRGKHSLEGSAPSERRMPPYANYFAQRSYPMPDEPFCTELTAEQRALKEKEKGSWTQLSHAEKVALYRLQFHQTFAEMNRRSNEWKTVMGCVFFFFGFAALLIWWQRVYMFPEKPITLTDEWKAKQLQRILDMKANPVQGLASRWDYEKKQWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FU12</accession>
    <name>A0A8B7FU12_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SLC6A8</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Creatine:sodium symporter which mediates the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>creatine(out) + chloride(out) + 2 Na(+)(out) = creatine(in) + chloride(in) + 2 Na(+)(in)</text>
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            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.</text>
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    <dbReference type="EMBL" id="ABDC03035284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012757212.3"/>
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        <property type="protein sequence ID" value="ENSMICP00000032146.1"/>
        <property type="gene ID" value="ENSMICG00000003428.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000155869"/>
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        <property type="component" value="Chromosome X"/>
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    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005309">
        <property type="term" value="F:creatine:sodium symporter activity"/>
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        <property type="term" value="F:gamma-aminobutyric acid:sodium:chloride symporter activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:neurotransmitter transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="SLC6sbd_CT1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Na/ntran_symport"/>
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        <property type="entry name" value="Na/ntran_symport_creatine"/>
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        <property type="entry name" value="SNS_sf"/>
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    <dbReference type="PANTHER" id="PTHR11616:SF96">
        <property type="entry name" value="SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1"/>
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    <dbReference type="PANTHER" id="PTHR11616">
        <property type="entry name" value="SODIUM/CHLORIDE DEPENDENT TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00209">
        <property type="entry name" value="SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CRTTRANSPORT"/>
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        <property type="entry name" value="NANEUSMPORT"/>
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    <dbReference type="SUPFAM" id="SSF161070">
        <property type="entry name" value="SNF-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="NA_NEUROTRAN_SYMP_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00754">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_2"/>
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    <dbReference type="PROSITE" id="PS50267">
        <property type="entry name" value="NA_NEUROTRAN_SYMP_3"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="11 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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    <feature type="transmembrane region" description="Helical" evidence="20">
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            <begin position="260"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="313"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="342"/>
            <end position="368"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="388"/>
            <end position="413"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="445"/>
            <end position="463"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="483"/>
            <end position="500"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
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            <end position="542"/>
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    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="41"/>
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    <feature type="binding site" evidence="16">
        <location>
            <position position="67"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="69"/>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
            <name>Na(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00006701"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00048833"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FXL4</accession>
    <name>A0A8B7FXL4_MICMU</name>
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        <recommendedName>
            <fullName evidence="7">Gamma-secretase subunit APH-1</fullName>
            <shortName evidence="7">APH-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">APH1B</name>
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    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the gamma-secretase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the APH-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614123.1">
        <property type="nucleotide sequence ID" value="XM_012758669.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FXL4"/>
    <dbReference type="Ensembl" id="ENSMICT00000061541.1">
        <property type="protein sequence ID" value="ENSMICP00000041618.1"/>
        <property type="gene ID" value="ENSMICG00000007117.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868106"/>
    <dbReference type="KEGG" id="mmur:105868106"/>
    <dbReference type="CTD" id="83464"/>
    <dbReference type="GeneTree" id="ENSGT00390000002049"/>
    <dbReference type="OrthoDB" id="6507463at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070765">
        <property type="term" value="C:gamma-secretase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034205">
        <property type="term" value="P:amyloid-beta formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007220">
        <property type="term" value="P:Notch receptor processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009294">
        <property type="entry name" value="Aph-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12889">
        <property type="entry name" value="GAMMA-SECRETASE SUBUNIT APH-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06105">
        <property type="entry name" value="Aph-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="257" mass="28537" checksum="D55CB8F7EA6AB607" modified="2022-01-19" version="1">MTAAVFFGCAFIAFGPALALYIFTIATESLRIIFLIAGAFFWLVSLLFSSLVWFVARAIADNREGPIQKYLLIFGVLVSVFIQELFRFAYYKLLKKASEGLKSVNPSDTAPSMQLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLNSAFMTLVIILLHTFWGIIFFDGCEKKNWYILLIVLLTHLLVSAQTFISPHYGLNLVSAYVIMVLMGIWAFFVAGGSCRTLKLCLLCQDKDFLLYSQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FYE7</accession>
    <name>A0A8B7FYE7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">small monomeric GTPase</fullName>
            <ecNumber evidence="5">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RAB8B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasmic vesicle membrane</location>
            <topology evidence="15">Lipid-anchor</topology>
            <orientation evidence="15">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="5"/>
    <dbReference type="EMBL" id="ABDC03004745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614122.1">
        <property type="nucleotide sequence ID" value="XM_012758668.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FYE7"/>
    <dbReference type="Ensembl" id="ENSMICT00000070796.1">
        <property type="protein sequence ID" value="ENSMICP00000042127.1"/>
        <property type="gene ID" value="ENSMICG00000043942.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105868105"/>
    <dbReference type="KEGG" id="mmur:105868105"/>
    <dbReference type="CTD" id="51762"/>
    <dbReference type="GeneTree" id="ENSGT00940000155363"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019003">
        <property type="term" value="F:GDP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019882">
        <property type="term" value="P:antigen processing and presentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000202">
        <property type="entry name" value="ras-related protein Rab-8A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="207" mass="23614" checksum="59609926BF87E3F4" modified="2022-01-19" version="1">MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSTNVEEAFFTLARDIMTKLNRKMNDSNSAGAGGPVKITENRSKKTSFFRCSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GJL9</accession>
    <name>A0A8B7GJL9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA processing 12 homolog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">RRP12</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019336">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622983.1">
        <property type="nucleotide sequence ID" value="XM_012767529.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000036353.2">
        <property type="protein sequence ID" value="ENSMICP00000034847.1"/>
        <property type="gene ID" value="ENSMICG00000007624.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873014"/>
    <dbReference type="KEGG" id="mmur:105873014"/>
    <dbReference type="CTD" id="23223"/>
    <dbReference type="GeneTree" id="ENSGT00390000013106"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="111"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="428"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1048"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1278"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1073"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1233"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1288"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1297" mass="143898" checksum="D13E7EE1124DEDA6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKP5</accession>
    <name>A0A8B7GKP5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Family with sequence similarity 131 member B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">FAM131B</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM131 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623557.1">
        <property type="nucleotide sequence ID" value="XM_012768103.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKP5"/>
    <dbReference type="Ensembl" id="ENSMICT00000060253.1">
        <property type="protein sequence ID" value="ENSMICP00000049947.1"/>
        <property type="gene ID" value="ENSMICG00000035869.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873295"/>
    <dbReference type="KEGG" id="mmur:105873295"/>
    <dbReference type="CTD" id="9715"/>
    <dbReference type="GeneTree" id="ENSGT00950000183106"/>
    <dbReference type="OrthoDB" id="8899318at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026782">
        <property type="entry name" value="FAM131"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15736:SF9">
        <property type="entry name" value="PROTEIN FAM131B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15736">
        <property type="entry name" value="PROTEIN FAM131B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15010">
        <property type="entry name" value="FAM131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="360" mass="38710" checksum="8934BB603E2C6BE8" modified="2022-01-19" version="1">MGCIGSRTVGNEVIAVDWKGLKDVDQINMDSTSSLHGSSLHRPSTEQTRTDFSWDGINLSMEDTTSILPKLKRNSNAYGIGALAKSSFSGISRSMKDHVTKPTAMGQGRVAHMIEWQGWGKTPAIQPQHSHEAVRRDTDAYSDLSDGEKEARFLAGVMEQFAISEATLMAWSSMDGEDMSVNSTQEPLGCNYSDNYQELMESQDALAQAPMDGWPHSYVSQGMYCLGSSDAWEASDQSLIASPATGSYLGPAFDDSQPSLHEMGPSQPASGYSAQEPAPLLGGDSDWAPGVGGVDLARGPAEEEKRPLAPEEEEDAGCRDLESLSPREDPEVSTALSRKVSDVTSSGVQSFDEEEGEANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GLK2</accession>
    <name>A0A8B7GLK2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Prolactin-inducible protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">PIP</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7 8">Monomer. Interacts with AZGP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015146">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623668.1">
        <property type="nucleotide sequence ID" value="XM_012768214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GLK2"/>
    <dbReference type="Ensembl" id="ENSMICT00000007445.3">
        <property type="protein sequence ID" value="ENSMICP00000006776.3"/>
        <property type="gene ID" value="ENSMICG00000007453.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105873368"/>
    <dbReference type="CTD" id="5304"/>
    <dbReference type="GeneTree" id="ENSGT00390000002099"/>
    <dbReference type="OrthoDB" id="9835042at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019864">
        <property type="term" value="F:IgG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001580">
        <property type="term" value="P:detection of chemical stimulus involved in sensory perception of bitter taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070233">
        <property type="term" value="P:negative regulation of T cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001572">
        <property type="entry name" value="Prolactin-inducible protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007990">
        <property type="entry name" value="PIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15096:SF5">
        <property type="entry name" value="PROLACTIN-INDUCIBLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15096">
        <property type="entry name" value="PROLACTIN-INDUCIBLE PROTEIN/SEMINAL VESICLE ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05326">
        <property type="entry name" value="SVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002572">
        <property type="entry name" value="PIP-GCDFP-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0873">Pyrrolidone carboxylic acid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133892" description="Prolactin-inducible protein homolog" evidence="11">
        <location>
            <begin position="28"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyrrolidone carboxylic acid" evidence="10">
        <location>
            <position position="28"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR002572-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR002572-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006776.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="146" mass="16623" checksum="DE3BB0FA12D91FA2" modified="2022-01-19" version="1">MRSLQLLFRASTGLLLVLCLQLGTIKTQEDTTRRAVIMNVDMPSRTRVNQEVSVKLNIETELTECLVCKAYLRSNVTMDGPFNYRFTVCVCKDAPRTLYWDFQVDKTMGIAVVVDTVRELGICPDDMAVIPIKANRYYYTTSLVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GND4</accession>
    <name>A0A8B7GND4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kazal type serine peptidase inhibitor domain 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KAZALD1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03019357">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624602.1">
        <property type="nucleotide sequence ID" value="XM_012769148.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GND4"/>
    <dbReference type="Ensembl" id="ENSMICT00000070432.1">
        <property type="protein sequence ID" value="ENSMICP00000045790.1"/>
        <property type="gene ID" value="ENSMICG00000042680.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873846"/>
    <dbReference type="KEGG" id="mmur:105873846"/>
    <dbReference type="CTD" id="81621"/>
    <dbReference type="GeneTree" id="ENSGT00530000063555"/>
    <dbReference type="OMA" id="TWNITGQ"/>
    <dbReference type="OrthoDB" id="10029006at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005614">
        <property type="term" value="C:interstitial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005520">
        <property type="term" value="F:insulin-like growth factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:003005">
        <property type="entry name" value="Kazal-type serine protease inhibitor domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000867">
        <property type="entry name" value="IGFBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011390">
        <property type="entry name" value="IGFBP_rP_mac25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186">
        <property type="entry name" value="INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14186:SF21">
        <property type="entry name" value="KAZAL-TYPE SERINE PROTEASE INHIBITOR DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00219">
        <property type="entry name" value="IGFBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018239">
        <property type="entry name" value="IGFBP_rP_mac25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51323">
        <property type="entry name" value="IGFBP_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133909" evidence="6">
        <location>
            <begin position="29"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="IGFBP N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="9">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="7">
        <location>
            <begin position="170"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="302" mass="32897" checksum="51004386C330CC4C" modified="2022-01-19" version="1">MPQSLVTALALPLLLLLLAVRTPPPTGARPSPGPDYLRRGWLRLLAEGEGCAPCQPEECAAPHGCLAGWVRDACGCCWECANLEGQLCDLDPSAHFYGRCGEQLECRLDAGGDLSRGEVPEPLCACRSQHPLCGSDGRTYAQICRLQEAARARPDANLTVAHPGPCESEPQIVSQPYDIWNVTGQDVIFGCEVFAYPMASIEWRKDGLDIQLPGDDPHISVQFRGGPQRFEVTGWLQIQAVRPSDEGTYRCLARNALGQVEAPASLTVLTPDQLNSTGIPQLRSLNLVPEEEAESEETEDYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GVZ4</accession>
    <name>A0A8B7GVZ4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Torsin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TOR1B</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014929">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627678.1">
        <property type="nucleotide sequence ID" value="XM_012772224.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GVZ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000009581.3">
        <property type="protein sequence ID" value="ENSMICP00000008719.2"/>
        <property type="gene ID" value="ENSMICG00000009585.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875289"/>
    <dbReference type="CTD" id="27348"/>
    <dbReference type="GeneTree" id="ENSGT00950000182888"/>
    <dbReference type="OrthoDB" id="19623at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019894">
        <property type="term" value="F:kinesin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034504">
        <property type="term" value="P:protein localization to nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000743">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017378">
        <property type="entry name" value="Torsin_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF14">
        <property type="entry name" value="TORSIN-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038079">
        <property type="entry name" value="Torsin_2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133970" description="Torsin" evidence="13">
        <location>
            <begin position="25"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR038079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038079-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008719.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="336" mass="38186" checksum="425F79F2166410B9" modified="2022-01-19" version="1">MRRTERLWGAAVLQLLLTARVVSALEPISVGIAIGAASLLTGYLSYKDIYCRFSECCREEQPFNASALKLDLEEKLFGQHVATEVIVKALTGFRSNKNPKKPLTLSLHGWAGTGKNFVSQIVAENLHPKGLKSNFVHLFVSTLHFPHEQKIKLYQDQLQKWIRGNVSACARSVFIFDEMDKLHPGIIDAIKPFLDYYEQVDGVSYRKAIFIFLSNAGGDLITKTALDFWLAGRKREDIQLKDLEPVLSVGVFNNKHSGLWRSGLIDRNLIDYFIPFLPLEYRHVKMCVRAEMRARGSAIDEDIVTKVAEEMTFFPKDEKIYSDKGCKTVQSRLDFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GX25</accession>
    <name>A0A8B7GX25_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iroquois homeobox 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IRX5</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/IRO homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024438">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628064.1">
        <property type="nucleotide sequence ID" value="XM_012772610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GX25"/>
    <dbReference type="Ensembl" id="ENSMICT00000027192.2">
        <property type="protein sequence ID" value="ENSMICP00000027079.1"/>
        <property type="gene ID" value="ENSMICG00000027848.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105875516"/>
    <dbReference type="KEGG" id="mmur:105875516"/>
    <dbReference type="CTD" id="10265"/>
    <dbReference type="GeneTree" id="ENSGT00940000159483"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048701">
        <property type="term" value="P:embryonic cranial skeleton morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008406">
        <property type="term" value="P:gonad development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042551">
        <property type="term" value="P:neuron maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060040">
        <property type="term" value="P:retinal bipolar neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000003">
        <property type="entry name" value="Iroquois-class homeobox protein IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003893">
        <property type="entry name" value="Iroquois_homeo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11211:SF17">
        <property type="entry name" value="IROQUOIS-CLASS HOMEODOMAIN PROTEIN IRX-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00548">
        <property type="entry name" value="IRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="117"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="119"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="483" mass="50329" checksum="17B7F1FF73584CC2" modified="2022-01-19" version="1">MSYPQGYLYQPSASLALYSCPAYSTSVISGPRTDELGRSSSGSAFSPYAGSTAFTAPSPGYNSHLQYGADPAAAAAAAFSSYVGSPYDHTPGMAGSLGYHPYAAPLGSYPYGDPAYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWTPRNRSEDEEEEENIDLEKNDEDEPQKPEDKGDPEGPEAGGAEQKAAPSCERLQGPPTPAGKETEGSLSDLDFKEPPSEGRLDALPGPPRAGGPSPAGPAAARLAEDPAPHYPAGAPAPATHPAAGELPPGPGGPSVIHSPPPPPPAAVLAKPKLWSLAEIATSSDKVKDGGGGSEGSPCPPCPGPIAGQALGGSRASPAPAPSRSPSAQCPFPGGTVLSRPLYYTAPFYPGYTNYGSFGHLHGHPGPGPGPTTGPGAHFNGLNQTVLNRADALAKDPKMLRSQSQLDLCKDSPYELKKGMSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GX55</accession>
    <name>A0A8B7GX55_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">E3 ubiquitin-protein ligase LRSAM1</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Leucine-rich repeat and sterile alpha motif-containing protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">RING-type E3 ubiquitin transferase LRSAM1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Tsg101-associated ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">LRSAM1</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Interacts with TSG101. Interacts with PHF23. Interacts with FUS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03014896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627434.1">
        <property type="nucleotide sequence ID" value="XM_012771980.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627435.1">
        <property type="nucleotide sequence ID" value="XM_012771981.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627436.1">
        <property type="nucleotide sequence ID" value="XM_012771982.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GX55"/>
    <dbReference type="Ensembl" id="ENSMICT00000047516.2">
        <property type="protein sequence ID" value="ENSMICP00000038989.1"/>
        <property type="gene ID" value="ENSMICG00000002341.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875212"/>
    <dbReference type="KEGG" id="mmur:105875212"/>
    <dbReference type="CTD" id="90678"/>
    <dbReference type="GeneTree" id="ENSGT00930000151044"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045806">
        <property type="term" value="P:negative regulation of endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904417">
        <property type="term" value="P:positive regulation of xenophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046755">
        <property type="term" value="P:viral budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd09523">
        <property type="entry name" value="SAM_TAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000252">
        <property type="entry name" value="E3 ubiquitin-protein ligase LRSAM1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000174">
        <property type="entry name" value="E3 ubiquitin-protein ligase LRSAM1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000059">
        <property type="entry name" value="E3 ubiquitin-protein ligase LRSAM1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF47">
        <property type="entry name" value="LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0072">Autophagy</keyword>
    <keyword evidence="18 25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SAM" evidence="27">
        <location>
            <begin position="572"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="26">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="314"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="468"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00065497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00067162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00078980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="728" mass="84288" checksum="927CFE87078680B1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GYS4</accession>
    <name>A0A8B7GYS4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain containing 126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">CCDC126</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015632">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015633">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628773.1">
        <property type="nucleotide sequence ID" value="XM_012773319.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628774.1">
        <property type="nucleotide sequence ID" value="XM_012773320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GYS4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059604.1">
        <property type="protein sequence ID" value="ENSMICP00000045280.1"/>
        <property type="gene ID" value="ENSMICG00000044703.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105875894"/>
    <dbReference type="KEGG" id="mmur:105875894"/>
    <dbReference type="CTD" id="90693"/>
    <dbReference type="GeneTree" id="ENSGT00940000153470"/>
    <dbReference type="OrthoDB" id="9946758at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042759">
        <property type="entry name" value="CCDC126"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027833">
        <property type="entry name" value="MGT5A-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46941">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46941:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15027">
        <property type="entry name" value="MGT5A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="MGT5A-like N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="140" mass="15668" checksum="2E50E2C624C894E0" modified="2022-01-19" version="1">MFFTISRKNMSQKLSLLLLVFGLIWGLMLLHYTFQQPRHQSSVKLREQILDLSKRYVKALAEENKNTVDVENGASMAGYADLKRTIAVLLDDILQRLVKLENKVDYIVVNGSATNSTNGTSGNLVPVTTNKRINASGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H185</accession>
    <name>A0A8B7H185_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intraflagellar transport protein 46 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">IFT46</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Cilium basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFT46 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007040">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012629063.1">
        <property type="nucleotide sequence ID" value="XM_012773609.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H185"/>
    <dbReference type="Ensembl" id="ENSMICT00000054084.2">
        <property type="protein sequence ID" value="ENSMICP00000026207.2"/>
        <property type="gene ID" value="ENSMICG00000015335.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876044"/>
    <dbReference type="KEGG" id="mmur:105876044"/>
    <dbReference type="CTD" id="56912"/>
    <dbReference type="GeneTree" id="ENSGT00390000005544"/>
    <dbReference type="OrthoDB" id="2119217at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022088">
        <property type="entry name" value="Intraflagellar_transp_cmplxB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13376:SF0">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 46 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12317">
        <property type="entry name" value="IFT46_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026207.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="302" mass="34102" checksum="1852A78610E509A2" modified="2022-01-19" version="1">MADNSSDEYEEENNKEKKKTSQLTSQRGFSENDDDDDDDSSETDSDDDDDDEEHGAPLEGAYDPADYEHLPVSSEIKELFQYISRYTPQLIDLDHKLKPFIPDFIPAVGDIDAFLKVPRPDGKPDNLGLLVLDEPSTKQSDPTVLSLWLTENSKQHNVMQHMKVKSLEDAEKNPKAIDTWIESISELHRSKPPATVHYTRPMPDIDTLMQEWSPEFEELLGKVSLPTAEIDCSLAEYIDMICAILDIPVYKSRIQSLHLLFSLYSEFKNSQHFKALAEGKKAFTPPSNSTSQAGDAETLTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H1L8</accession>
    <name>A0A8B7H1L8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein O-glucosyltransferase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POGLUT3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-glucosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:58116"/>
            <dbReference type="Rhea" id="RHEA-COMP:14610"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140576"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-(beta-D-xylosyl)-L-seryl-[EGF-like domain protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62016"/>
            <dbReference type="Rhea" id="RHEA-COMP:16010"/>
            <dbReference type="Rhea" id="RHEA-COMP:16011"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:132085"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KDELC family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006847">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H1L8"/>
    <dbReference type="Ensembl" id="ENSMICT00000003463.3">
        <property type="protein sequence ID" value="ENSMICP00000003151.3"/>
        <property type="gene ID" value="ENSMICG00000003463.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105876124"/>
    <dbReference type="KEGG" id="mmur:105876124"/>
    <dbReference type="CTD" id="143888"/>
    <dbReference type="GeneTree" id="ENSGT00940000159028"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000419">
        <property type="entry name" value="KDEL (Lys-Asp-Glu-Leu) containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001298">
        <property type="entry name" value="Filamin/ABP280_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF18">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00557">
        <property type="entry name" value="IG_FLMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134016" evidence="12">
        <location>
            <begin position="21"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="Filamin" evidence="11">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="13">
        <location>
            <begin position="231"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003151.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="508" mass="58525" checksum="74FF35B0F1F5DB71" modified="2022-01-19" version="1">MRRLARALLLPLQLALLAAAGAPEAPVSARRSLVWGPGLQAAVVLPVRYFYLQAVNSEGHNLTRAPPGQTSFKVVVKSLSPKELVRIHVPKPLDRNDGTFLIRYRMYETVNEGLKIEVLYGDEHVAQSPYILKGPVYHEYCECPEEDPQAWQTILSCPTEEPQIAKDFTSFASINLQQMLNEVPKRFGDERGAVVHYTILNNHIYRRSLGKYTDFKMFSDEILLSLARKVLLPDLEFYINLGDWPLEHRKVNETPGPVPIISWCGSLDSRDIILPTYDITHSTLEAMRGVTNDLLSIQGNTGPSWINKTEKAFFRGRDSREERLQLVQLSKENPQLLDAGITGYFFFQEKEKELGKAKLTGFFDFFKYKYQVNVDGTVAAYRYPYLMLGDSLVLKQDSPYYEHFYMALKPWKHYVPIKRNLSDLLEKVKWAKENDEEAKKIAKEGQLTARDLLQPHRLYCYYYRVLQKYAEHQASKPEIRDGMELVPQPEDSTSICECHRKNPLREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H5S0</accession>
    <name>A0A8B7H5S0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intraflagellar transport protein 25 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heat shock protein beta-11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Placental protein 25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">IFT25</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the IFT complex B, at least composed of IFT20, IFT22, IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT27. Interacts with IFT88.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IFT25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001459">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631769.1">
        <property type="nucleotide sequence ID" value="XM_012776315.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631772.1">
        <property type="nucleotide sequence ID" value="XM_012776318.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631773.1">
        <property type="nucleotide sequence ID" value="XM_012776319.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631778.1">
        <property type="nucleotide sequence ID" value="XM_012776324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H5S0"/>
    <dbReference type="Ensembl" id="ENSMICT00000058877.1">
        <property type="protein sequence ID" value="ENSMICP00000041585.1"/>
        <property type="gene ID" value="ENSMICG00000045633.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105877597"/>
    <dbReference type="CTD" id="51668"/>
    <dbReference type="GeneTree" id="ENSGT00390000012620"/>
    <dbReference type="OrthoDB" id="271080at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030992">
        <property type="term" value="C:intraciliary transport particle B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007507">
        <property type="term" value="P:heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042073">
        <property type="term" value="P:intraciliary transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001822">
        <property type="term" value="P:kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070986">
        <property type="term" value="P:left/right axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030324">
        <property type="term" value="P:lung development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000081">
        <property type="entry name" value="Intraflagellar transport protein 25 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033558">
        <property type="entry name" value="IFT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33906:SF1">
        <property type="entry name" value="INTRAFLAGELLAR TRANSPORT PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="12">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00063061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="143" mass="16459" checksum="49481905BB4C5C0A" modified="2022-01-19" version="1">MRKLDLCLSSEGSEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIIFFHKHVKIERLVIQSYFVRTLRIEKSTSKEPVDFEQWIEKDLIHTEGQLQNEEFVARDGYATYLRFVIISAFDHFASVHSISADGTVISDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H8C5</accession>
    <name>A0A8B7H8C5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">DNA polymerase</fullName>
            <ecNumber evidence="27">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">POLB</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="27">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="function">
        <text evidence="23">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24 27">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="25">Monomer. Binds single-stranded DNA (ssDNA). Interacts with APEX1, LIG1, LIG3, FEN1, PCNA and XRCC1. Interacts with HUWE1/ARF-BP1, STUB1/CHIP and USP47. Interacts with FAM168A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 27">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 27">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="27"/>
    <dbReference type="EMBL" id="ABDC03023558">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632850.1">
        <property type="nucleotide sequence ID" value="XM_012777396.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H8C5"/>
    <dbReference type="Ensembl" id="ENSMICT00000042133.2">
        <property type="protein sequence ID" value="ENSMICP00000033385.1"/>
        <property type="gene ID" value="ENSMICG00000006594.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878145"/>
    <dbReference type="KEGG" id="mmur:105878145"/>
    <dbReference type="CTD" id="5423"/>
    <dbReference type="GeneTree" id="ENSGT00940000156918"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000002">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000026">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000008">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000021">
        <property type="entry name" value="DNA polymerase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF42">
        <property type="entry name" value="DNA POLYMERASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
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        <property type="entry name" value="DNA_pol_B_thumb"/>
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        <property type="entry name" value="DNA_pol_lambd_f"/>
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        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
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    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 27" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18 27" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="17" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 27" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="19" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 27" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20 27" id="KW-0539">Nucleus</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 27" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="29">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="28">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helix-hairpin-helix DNA-binding motif class 1" evidence="28">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="26">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
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            <dbReference type="ARBA" id="ARBA00022932"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00066185"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
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    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
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    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00278"/>
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    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00483"/>
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    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="335" mass="38267" checksum="699F7BEEAA2EBF80" modified="2022-01-19" version="1">MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLRYFEDFEKRIPREEMLQMQDIVLNEVEKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHRVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNEDKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEALPVDSEKDVFDYIQWKYREPKDRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBJ5</accession>
    <name>A0A8B7HBJ5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Solute carrier family 38 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SLC38A6</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004062">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633094.1">
        <property type="nucleotide sequence ID" value="XM_012777640.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HBJ5"/>
    <dbReference type="Ensembl" id="ENSMICT00000017681.3">
        <property type="protein sequence ID" value="ENSMICP00000016100.2"/>
        <property type="gene ID" value="ENSMICG00000017681.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878309"/>
    <dbReference type="KEGG" id="mmur:105878309"/>
    <dbReference type="CTD" id="145389"/>
    <dbReference type="GeneTree" id="ENSGT00940000156982"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015186">
        <property type="term" value="F:L-glutamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF366">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="46"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016100.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="456" mass="50757" checksum="8B1B447EC15E3FBC" modified="2022-01-19" version="1">METSQESINAERGWYVSAQQPEEAEAEELSPLLSNELHRQGSSGVSFGFSVFNLMNAIMGSGILGLAYVMANTGILGFSFLLLIVALLASYSVHLLLSMCIQTAVTSYEDLGLFAFGLPGKVVVAGTIIIQNIGAMSSYLFIIKTELPAAISEFLTGDYSGSWYLDGQTLLIVICVGIVFPLALLPKIGFLGYTSSLSFFFMVFFTLVIIIKKWSIPCPLTLNYLKECFQIPNVTDDCKPKLFHFSKESAYAIPTMAFSFLCHTSILPIYCELQSPSKKRMQNVTNTAIALSFLIYFISALFGYLTFYGKVESELLQGYNKYLPHDVVVMTVKLCILFAVLLTVPLIHFPARKALTMIFFSNFPFSWIRHSLITLALNVVIVLLAIYVPDIRNIFGVVGASTSTCLIFIFPGLFYLKLSREDFVSWKKLGAFILFFFGILIGNFSLALIIFDWINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HGQ4</accession>
    <name>A0A8B7HGQ4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 39A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM39A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM39 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001106">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636039.1">
        <property type="nucleotide sequence ID" value="XM_012780585.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HGQ4"/>
    <dbReference type="Ensembl" id="ENSMICT00000072963.1">
        <property type="protein sequence ID" value="ENSMICP00000051235.1"/>
        <property type="gene ID" value="ENSMICG00000049505.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879927"/>
    <dbReference type="KEGG" id="mmur:105879927"/>
    <dbReference type="CTD" id="55254"/>
    <dbReference type="GeneTree" id="ENSGT00390000018895"/>
    <dbReference type="OrthoDB" id="5862608at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902902">
        <property type="term" value="P:negative regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901097">
        <property type="term" value="P:negative regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045070">
        <property type="term" value="P:positive regulation of viral genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019397">
        <property type="entry name" value="Uncharacterised_TMEM39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995">
        <property type="entry name" value="FI21814P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12995:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 39A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10271">
        <property type="entry name" value="Tmp39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="488" mass="55710" checksum="27C7A7C79CEA81CD" modified="2022-01-19" version="1">MPGGRRGPSRQQLSRSALPSLQTLVGGSCGNGTGLRNRNGSAVGLPVPPITALITPGPVRHCQIPDLPVDGSLLFEFLFFIYLLVALFIQYINIYKTVWWYPYNHPASCTSLNFHLIDYHLAAFITVMLARRLVWALISEATKAGAASMIHYMVLISARLVLLTLCGWVLCWTLVNLFRSHSVLNLLFLGYPFGVYVPLCCFHQDSRAHLLLTDYNYVVQHQVVEESASTVGGLAKSKDFLSLLLESLKEQFNNATPIPTHSCPLSPDLIRNEVECLKADFNHRIKEVLFNSLFSAYYVAFLPLCFVKSTQYYDMRWSCEHLIMVWINAFVMLTTQLLPSKYCDLLHKSAAHLGKWQKLEHGSYSNAPQHIWSENTIWPQGVLVRHSRCLYRAMGPYNVAVPSDVSHARFYFLFHRPLRLLNLLILIEGSVVFYQLYSLLRSEKWNHTLSMALILFCNYYVLFKLLRDRIVLGRAYSYPLNSYELKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HH93</accession>
    <name>A0A8B7HH93_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein PALS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">MAGUK p55 subfamily member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein associated with Lin-7 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PALS1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004028">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HH93"/>
    <dbReference type="Ensembl" id="ENSMICT00000010773.3">
        <property type="protein sequence ID" value="ENSMICP00000009817.3"/>
        <property type="gene ID" value="ENSMICG00000010772.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880235"/>
    <dbReference type="KEGG" id="mmur:105880235"/>
    <dbReference type="CTD" id="64398"/>
    <dbReference type="GeneTree" id="ENSGT00940000156087"/>
    <dbReference type="OrthoDB" id="43580at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043219">
        <property type="term" value="C:lateral loop"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035749">
        <property type="term" value="C:myelin sheath adaxonal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043220">
        <property type="term" value="C:Schmidt-Lanterman incisure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021954">
        <property type="term" value="P:central nervous system neuron development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021987">
        <property type="term" value="P:cerebral cortex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002011">
        <property type="term" value="P:morphogenesis of an epithelial sheet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032287">
        <property type="term" value="P:peripheral nervous system myelin maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035750">
        <property type="term" value="P:protein localization to myelin sheath abaxonal region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017015">
        <property type="term" value="P:regulation of transforming growth factor beta receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06798">
        <property type="entry name" value="PDZ_MPP5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12036">
        <property type="entry name" value="SH3_MPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000105">
        <property type="entry name" value="MAGUK p55 subfamily member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
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</entry>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <scope>IDENTIFICATION</scope>
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</entry>
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    <accession>A0A8B7HKV3</accession>
    <name>A0A8B7HKV3_MICMU</name>
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        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
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        <name evidence="10" type="primary">MED7</name>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
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                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027455">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637041.1">
        <property type="nucleotide sequence ID" value="XM_012781587.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637042.1">
        <property type="nucleotide sequence ID" value="XM_012781588.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HKV3"/>
    <dbReference type="Ensembl" id="ENSMICT00000002536.3">
        <property type="protein sequence ID" value="ENSMICP00000002314.2"/>
        <property type="gene ID" value="ENSMICG00000002539.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880504"/>
    <dbReference type="KEGG" id="mmur:105880504"/>
    <dbReference type="CTD" id="9443"/>
    <dbReference type="GeneTree" id="ENSGT00940000154444"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035019">
        <property type="term" value="P:somatic stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051669">
        <property type="entry name" value="Immune_Mod/Transcr_Coactivator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15498:SF72">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15498">
        <property type="entry name" value="T-CELL IMMUNOGLOBULIN AND MUCIN DOMAIN CONTAINING TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002314.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="233" mass="27245" checksum="49A5A2A83613157A" modified="2022-01-19" version="1">MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADDSNNCTGQNEQHRENSGHRRDQIIEKDAALCVLIDEMNERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HNS6</accession>
    <name>A0A8B7HNS6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC105881941</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006420">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639389.1">
        <property type="nucleotide sequence ID" value="XM_012783935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HNS6"/>
    <dbReference type="Ensembl" id="ENSMICT00000029855.2">
        <property type="protein sequence ID" value="ENSMICP00000036187.2"/>
        <property type="gene ID" value="ENSMICG00000046534.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105881941"/>
    <dbReference type="KEGG" id="mmur:105881941"/>
    <dbReference type="GeneTree" id="ENSGT01150000286945"/>
    <dbReference type="OrthoDB" id="9011197at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15416">
        <property type="entry name" value="7tmA_OR5P-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="44"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036187.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="324" mass="35876" checksum="D82BE76FA763537B" modified="2022-01-19" version="1">MDSLVVRNHTAVTEFILLGLTDDPVLRVISFMIILCIYLVTISGNLSIIILIRISSQLHHPMYFFLSNLASADIGFSSSVTPNMLVNFLVERNTISYLGCVTQLGSTAFFGTVECFLLAAMAYDRFVAICNPLLYSAKMSTQVCVQLLVVAYLGGFLNASSFIFSFFSLLFCGPNRVNHFFCDFAPLIELSCSDASVSTAVPSFSSGTIIVVTVFVIAISYIYILITILKMRSTEGRHKAFSTCTSHLTAVTLFYGTITFIYVMPKSSYSTDQNKVVSVFYTVVIPMLNPLIYSLRNKEIKGALKRELGRGMFSSDACYFCRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HQ28</accession>
    <name>A0A8B7HQ28_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Leucine rich repeat containing 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LRRC26</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SLITRK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639938.1">
        <property type="nucleotide sequence ID" value="XM_012784484.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HQ28"/>
    <dbReference type="Ensembl" id="ENSMICT00000062950.1">
        <property type="protein sequence ID" value="ENSMICP00000042844.1"/>
        <property type="gene ID" value="ENSMICG00000042486.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882257"/>
    <dbReference type="KEGG" id="mmur:105882257"/>
    <dbReference type="CTD" id="389816"/>
    <dbReference type="GeneTree" id="ENSGT00940000162780"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099104">
        <property type="term" value="F:potassium channel activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051965">
        <property type="term" value="P:positive regulation of synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000015">
        <property type="entry name" value="Leucine rich repeat containing 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000483">
        <property type="entry name" value="Cys-rich_flank_reg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45773:SF5">
        <property type="entry name" value="SLIT AND NTRK-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00082">
        <property type="entry name" value="LRRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134150" evidence="17">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LRRCT" evidence="18">
        <location>
            <begin position="203"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="297"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="335" mass="35103" checksum="1048BE3FA43D950D" modified="2022-01-19" version="1">MRSLFFSLPPPFLLLVLLVLLSPWPVWAQAPATTFPSGPRGDPDCPEACACVPGGQANCSALALAAVPAGLSRRVSALLLDHNCLSALPPGAFVGAGALLRLDLRENGLRSVHMRAFWGLGALQYLDLSANQLEVLAPGTFAPLRALRTLSLAGNRLARLEPAALSALPLLRALNLQDNALTALTPGLLAGLPALDSLRLRGNPWACSCALRPLCTWLRRHPPPAAEAETLLCTSPRRLRLSPLTAFSDAAFSHCAKPLAPRDLAVIYVLGPASFLASLAACLALGSVITACRARSRRRTAARRPPRRPPDPDPDLEGSASPADPASPAAAAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HWQ9</accession>
    <name>A0A8B7HWQ9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mercaptopyruvate sulfurtransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MPST</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03008868">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642580.1">
        <property type="nucleotide sequence ID" value="XM_012787126.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642581.1">
        <property type="nucleotide sequence ID" value="XM_012787127.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HWQ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000009037.3">
        <property type="protein sequence ID" value="ENSMICP00000008231.3"/>
        <property type="gene ID" value="ENSMICG00000009041.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883733"/>
    <dbReference type="CTD" id="4357"/>
    <dbReference type="GeneTree" id="ENSGT00510000046773"/>
    <dbReference type="OMA" id="NNNWFAS"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016784">
        <property type="term" value="F:3-mercaptopyruvate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009440">
        <property type="term" value="P:cyanate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000098">
        <property type="term" value="P:sulfur amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000008">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008557">
        <property type="entry name" value="PRK11493.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF25">
        <property type="entry name" value="3-MERCAPTOPYRUVATE SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="25"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="174"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008231.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="297" mass="33031" checksum="48947478B06F6E13" modified="2022-01-19" version="1">MAPPQLFRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKMGRDARREFEERHIPGAAFFDLDQCSDRTSPYDHMLPGEAQFAEYVGHLGVGAATHVVIYDASDQGLYSAPRVWWMFRAFGHHTVSLLDGGLRHWLSQGLPLSSGKSHQAPAEFRAELDPAFVKTYEDVKENLESRRFQVVDARAAGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLTGEGLEKSPEEIHHLFQEKKVDLSQPLVATCGSGVTACHVALGAYLCGKPDIPVYDGSWVEWYMRAQPEDIISEGRGKTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I4Q5</accession>
    <name>A0A8B7I4Q5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable splicing factor YJU2B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Coiled-coil domain-containing protein 130</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">YJU2B</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May be involved in mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027769">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I4Q5"/>
    <dbReference type="Ensembl" id="ENSMICT00000011910.3">
        <property type="protein sequence ID" value="ENSMICP00000010847.3"/>
        <property type="gene ID" value="ENSMICG00000011911.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000034239.2">
        <property type="protein sequence ID" value="ENSMICP00000019318.1"/>
        <property type="gene ID" value="ENSMICG00000011911.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885483"/>
    <dbReference type="KEGG" id="mmur:105885483"/>
    <dbReference type="CTD" id="81576"/>
    <dbReference type="GeneTree" id="ENSGT00530000063615"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010847.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="393" mass="44247" checksum="C7EA4F31BB024141" modified="2022-01-19" version="1">MGERKGVNKYYPPDFNPEKHGSLNRYHNSHPLRERARKLSQGILVIRFEMPYNIWCDGCKNHIGMGVRYNAEKKKVGNYYTTPIYRFRMKCHLCVNYIEMQTDPANCDYVIVSGAQRKEERWDMADNEQVLTTEHEKKQKLETDAMFRLEHGEADRSALKKALPTLSHIQEAQSAWKDDFALNSMLRRRFREKKKAIQEEEERDQALQAKASLTIPLVPETEDDRRLAALLKFHTLDSYEDKQKLKRTEIISRSWFPSAPGSGPSSKVGSVLKKLAQSRRPVPAGSPISVGDLGIVRRRSRDVPESPQHGAETPKSGEAQVPQGTAQDWPTSPGDCPQEPAKTPKTSSQEGSCQDKPLSPPGSSQEAAEPPDRPQPCTAGSSLVADYSDSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I6H2</accession>
    <name>A0A8B7I6H2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Abhydrolase domain containing 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ABHD18</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018742">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018743">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018744">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646544.1">
        <property type="nucleotide sequence ID" value="XM_012791090.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646545.1">
        <property type="nucleotide sequence ID" value="XM_012791091.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646546.1">
        <property type="nucleotide sequence ID" value="XM_012791092.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646547.1">
        <property type="nucleotide sequence ID" value="XM_012791093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I6H2"/>
    <dbReference type="Ensembl" id="ENSMICT00000030880.2">
        <property type="protein sequence ID" value="ENSMICP00000021611.2"/>
        <property type="gene ID" value="ENSMICG00000011534.3"/>
    </dbReference>
    <dbReference type="CTD" id="80167"/>
    <dbReference type="GeneTree" id="ENSGT00390000014635"/>
    <dbReference type="OrthoDB" id="9987145at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019149">
        <property type="entry name" value="ABHD18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13617:SF14">
        <property type="entry name" value="PROTEIN ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09752">
        <property type="entry name" value="ABHD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021611.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="462" mass="52901" checksum="81753DBB5F45DBEC" modified="2022-01-19" version="1">MGVSKLDIIYRRLLLTKLFIRGWGRPEDLKRLFEFRKVIGNRERCQNLVSRDYPVYIDKIEEQSDCKILDGHFVSPMAHYVPGIMPIESVIARFQFIVPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESATLLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTGVLSKSINWRELEKQYYTQTVYEEEIIHMLEYCGADSFKMGQEFVKHFPSSADKLTNLNLVSRTLNLDDQVVSQKPAECQNSSKTSISATSERLLLQDASKKECFNQTLSTNKSSYTSCSSQSYHLLSKEQRRNNLQKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQAIYDAFERFLHKYAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WL24</accession>
    <name>A0A8B7WL24_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription factor HIVEP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Kappa-B and V(D)J recombination signal sequences-binding protein</fullName>
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        <alternativeName>
            <fullName evidence="17">Kappa-binding protein 1</fullName>
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        <alternativeName>
            <fullName evidence="15">Zinc finger protein ZAS3</fullName>
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    </protein>
    <gene>
        <name evidence="22" type="primary">HIVEP3</name>
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    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="13">Interacts with TRAF1 and TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001733">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001734">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001735">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012735840.1"/>
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    <dbReference type="RefSeq" id="XP_020135971.1">
        <property type="nucleotide sequence ID" value="XM_020280382.1"/>
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    <dbReference type="Ensembl" id="ENSMICT00000045174.2">
        <property type="protein sequence ID" value="ENSMICP00000025367.1"/>
        <property type="gene ID" value="ENSMICG00000037990.2"/>
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    <dbReference type="GeneID" id="105855094"/>
    <dbReference type="KEGG" id="mmur:105855094"/>
    <dbReference type="CTD" id="59269"/>
    <dbReference type="GeneTree" id="ENSGT00940000157218"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.160.60:FF:000083">
        <property type="entry name" value="Immunodeficiency virus type I enhancer binding protein 1"/>
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        <property type="entry name" value="Zinc finger protein 574"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
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        <property type="entry name" value="Zinc-finger_DNA-bd_regulators"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="Znf_CCHC_HIVEP"/>
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        <property type="entry name" value="SCHNURRI, ISOFORM F"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR HIVEP3"/>
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        <property type="entry name" value="zf-C2H2"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="17">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 17">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion inner membrane</location>
            <topology evidence="1 17">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="4 17"/>
    <dbReference type="EMBL" id="ABDC03024118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138056.1">
        <property type="nucleotide sequence ID" value="XM_020282467.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138057.1">
        <property type="nucleotide sequence ID" value="XM_020282468.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138058.1">
        <property type="nucleotide sequence ID" value="XM_020282469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WRY5"/>
    <dbReference type="Ensembl" id="ENSMICT00000064649.1">
        <property type="protein sequence ID" value="ENSMICP00000049037.1"/>
        <property type="gene ID" value="ENSMICG00000011378.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105859008"/>
    <dbReference type="CTD" id="1723"/>
    <dbReference type="GeneTree" id="ENSGT00500000044924"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000066">
        <property type="entry name" value="Dihydroorotate dehydrogenase (quinone), mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00225">
        <property type="entry name" value="DHO_dh_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003645">
        <property type="entry name" value="PRK05286.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003652">
        <property type="entry name" value="PRK05286.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01036">
        <property type="entry name" value="pyrD_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 17" id="KW-0288">FMN</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="18">
        <location>
            <begin position="77"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="395" mass="42714" checksum="6A3B732B139C0F5B" modified="2022-01-19" version="1">MAWRHLKKRAQDALVILGGGGFVFASYLTATGDEHFYTQHLMPALQRLLDPESAHRLAVQCTSLGLLPRTSFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSQGLSAVEHRLRARQQKQAKLTEDGLPLGINLGKNKTSADAAADYAEGVRVLGPLADYLVVNVSSPNTAGLRCLQGKAELRCLLTKVLQEREALQGARKPAVLVKIAPDLTAQDKEDIASIVRELGVDGLIVTNTTVSRPASLQGTLCSEVGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVGSGQDALEKIRAGASLVQLYTALTYQGPPVVGRVKRELEALLKEQGFRRVTDAIGADHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WXT5</accession>
    <name>A0A8B7WXT5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lymphoid enhancer-binding factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">LEF1</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCF/LEF family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030236">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03030237">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140079.1">
        <property type="nucleotide sequence ID" value="XM_020284490.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WXT5"/>
    <dbReference type="Ensembl" id="ENSMICT00000061073.1">
        <property type="protein sequence ID" value="ENSMICP00000047661.1"/>
        <property type="gene ID" value="ENSMICG00000012833.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872329"/>
    <dbReference type="CTD" id="51176"/>
    <dbReference type="GeneTree" id="ENSGT00940000159660"/>
    <dbReference type="OrthoDB" id="2307332at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990907">
        <property type="term" value="C:beta-catenin-TCF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060070">
        <property type="term" value="P:canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21996">
        <property type="entry name" value="HMG-box_TCF7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.900.10:FF:000004">
        <property type="entry name" value="lymphoid enhancer-binding factor 1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000001">
        <property type="entry name" value="transcription factor 7 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.900.10">
        <property type="entry name" value="TCF3-CBD (Catenin binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027397">
        <property type="entry name" value="Catenin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013558">
        <property type="entry name" value="CTNNB1-bd_N"/>
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    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
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        <property type="entry name" value="HMG_box_dom_sf"/>
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    <dbReference type="InterPro" id="IPR024940">
        <property type="entry name" value="TCF/LEF"/>
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    <dbReference type="PANTHER" id="PTHR10373:SF11">
        <property type="entry name" value="LYMPHOID ENHANCER-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10373">
        <property type="entry name" value="TRANSCRIPTION FACTOR 7 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08347">
        <property type="entry name" value="CTNNB1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="13">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="268"/>
            <end position="298"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="369"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="269"/>
            <end position="296"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006569"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="ARBA" id="ARBA00023159"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074467"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50118"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047661.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="399" mass="43955" checksum="B81E33A120CA8031" modified="2022-01-19" version="1">MPQLSGGGGGGAGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVARPAQTAREPYHDKAGEHPEDGKHPDGGLYSKGPSYSSYSSYIMMPNMNNDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPPHIPPDVGSKPGMSRHPPAPDIPAFYPLSPGGVGQITPPLGWQGQPVYPISGGFRQPYPSSLSADASLSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XA62</accession>
    <name>A0A8B7XA62_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formin like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">FMNL2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin homology family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011168">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011169">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144050.1">
        <property type="nucleotide sequence ID" value="XM_020288461.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XA62"/>
    <dbReference type="Ensembl" id="ENSMICT00000036526.2">
        <property type="protein sequence ID" value="ENSMICP00000028041.2"/>
        <property type="gene ID" value="ENSMICG00000017132.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879596"/>
    <dbReference type="CTD" id="114793"/>
    <dbReference type="GeneTree" id="ENSGT00940000155515"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000001">
        <property type="entry name" value="Formin-like 1, isoform CRA_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000036">
        <property type="entry name" value="Formin-like protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000045">
        <property type="entry name" value="Formin-like protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043592">
        <property type="entry name" value="FMNL_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857">
        <property type="entry name" value="FORMIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45857:SF5">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="5">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="6">
        <location>
            <begin position="614"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="4">
        <location>
            <begin position="1037"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="504"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="381"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="979"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="580"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028041.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1090" mass="123751" checksum="50BB4496642FC1A3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XEU3</accession>
    <name>A0A8B7XEU3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="11">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PPIP5K2</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03016827">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145745.1">
        <property type="nucleotide sequence ID" value="XM_020290156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XEU3"/>
    <dbReference type="Ensembl" id="ENSMICT00000043906.2">
        <property type="protein sequence ID" value="ENSMICP00000024406.1"/>
        <property type="gene ID" value="ENSMICG00000004779.3"/>
    </dbReference>
    <dbReference type="CTD" id="23262"/>
    <dbReference type="GeneTree" id="ENSGT00390000009048"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000828">
        <property type="term" value="F:inositol hexakisphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000001">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000003">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000013">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF10">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="13">
        <location>
            <begin position="44"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="898"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="966"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1160"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1237" mass="139780" checksum="21DED424B475E0F7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJM0</accession>
    <name>A0A8C5UJM0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ICOS ligand</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">B7 homolog 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">B7-like protein Gl50</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">B7-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ICOSLG</name>
        <name evidence="22" type="synonym">LOC105879096</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the immunoglobulin superfamily. BTN/MOG family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033283">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033284">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033285">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJM0"/>
    <dbReference type="Ensembl" id="ENSMICT00000001247.3">
        <property type="protein sequence ID" value="ENSMICP00000001137.2"/>
        <property type="gene ID" value="ENSMICG00000001250.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161590"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048018">
        <property type="term" value="F:receptor ligand activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042104">
        <property type="term" value="P:positive regulation of activated T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061470">
        <property type="term" value="P:T follicular helper cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001468">
        <property type="entry name" value="ICOS ligand isoform b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000996">
        <property type="entry name" value="ICOS ligand isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053896">
        <property type="entry name" value="BTN3A2-like_Ig-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050504">
        <property type="entry name" value="IgSF_BTN/MOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100">
        <property type="entry name" value="BUTYROPHILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24100:SF151">
        <property type="entry name" value="ICOS LIGAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22705">
        <property type="entry name" value="C2-set_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="13" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="10 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034489134" description="ICOS ligand" evidence="20">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="21">
        <location>
            <begin position="142"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="292"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00080938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00081259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00082272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001137.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="338" mass="37243" checksum="67DF91DF4035F9A1" modified="2022-01-19" version="1">MWLSPRLFLLLSSLQAGVAYIQEKEVRAMVGSNVELGCVSPEEGSFDLNDLFVYWQISERNTVVTYYLPQNSSTTHVDSHYRSRAWLSLDSMRRGDFSLHLFNVTPQDGQKFHCLVFRKSLEMKQVLQTVVTLHVAANYSMPVVSTPSGPLQDELTFTCTSTNGYPRPNVYWINKTDNSLLDAALQNSTVSLNDRGLYDVVSVLRIGWTPNVNVGCCIENVLLHQNLTVSSQAEAFTGTQDKIIEKSGLTPQEQTTILYVVAGCVAVAVVAAGWMCWKKRCPQGHYAGAQAARPEPELAGESARTPRGPGRPGHCPSQTCADPSDGLGFPSRRSPDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UL02</accession>
    <name>A0A8C5UL02_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin 82</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KRT82</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UL02"/>
    <dbReference type="Ensembl" id="ENSMICT00000002179.3">
        <property type="protein sequence ID" value="ENSMICP00000001994.3"/>
        <property type="gene ID" value="ENSMICG00000002177.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161849"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF12">
        <property type="entry name" value="KERATIN, TYPE II CUTICULAR HB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="118"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="327"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001994.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="511" mass="56570" checksum="4C614BC2DE9BB60F" modified="2022-01-19" version="1">MSCRSFQPSSRCGSRSFSSYSAVMPRMVTQYAVSKGPCRPVGSGGLRAVGCLGSRSLCNVGFGRPRVASRCGLPSFGYRVGATCGPSACITPVSINESLLVPLQLEIDPTVQRVKRDEKEQIKCLNNRFASFINKVRFLEQKNKLLETKWNFMQQQRCCQSNMEPIFESYICALRRQLDCVSGEHVRLESELCSLQNVLEGYKKKYEEELSLRPCVENDFVALKKEVDTAFLMKADLETNAEALVQEIDFLKGLYEEEICLLQSQISETSVIVKMDNSRELDVDSIIAEIKAQYDDIATRSKAEAEAWYQCRYEELRLTAGNHCDNLRNRKNEILEMNKLIQRLQQEIETVKAQRCKLEGTIAEAEQQGEAALNDAKCKLAGLEEALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEEHRLCEGIGPVNISVSSSKGAVLYEPCGVSTPMLRTGVLRSSGGCSVVGTGELYVPCDPQGLLGCGGGRSSSAKLGAGSSPCSHKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM60</accession>
    <name>A0A8C5UM60_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Keratin 85</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">KRT85</name>
        <name evidence="8" type="synonym">LOC105870410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the intermediate filament family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009604">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UM60"/>
    <dbReference type="Ensembl" id="ENSMICT00000002165.3">
        <property type="protein sequence ID" value="ENSMICP00000001982.2"/>
        <property type="gene ID" value="ENSMICG00000002165.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105870410"/>
    <dbReference type="GeneTree" id="ENSGT00940000162337"/>
    <dbReference type="OrthoDB" id="9440123at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045095">
        <property type="term" value="C:keratin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030280">
        <property type="term" value="F:structural constituent of skin epidermis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045109">
        <property type="term" value="P:intermediate filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031424">
        <property type="term" value="P:keratinization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1160:FF:000001">
        <property type="entry name" value="Keratin type II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000004">
        <property type="entry name" value="Keratin, type II cytoskeletal 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.500:FF:000001">
        <property type="entry name" value="Type II keratin 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1160">
        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018039">
        <property type="entry name" value="IF_conserved"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039008">
        <property type="entry name" value="IF_rod_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032444">
        <property type="entry name" value="Keratin_2_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003054">
        <property type="entry name" value="Keratin_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616">
        <property type="entry name" value="GATA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45616:SF43">
        <property type="entry name" value="KERATIN, TYPE II CUTICULAR HB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00038">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16208">
        <property type="entry name" value="Keratin_2_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01276">
        <property type="entry name" value="TYPE2KERATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01391">
        <property type="entry name" value="Filament"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64593">
        <property type="entry name" value="Intermediate filament protein, coiled coil region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00226">
        <property type="entry name" value="IF_ROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51842">
        <property type="entry name" value="IF_ROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0403">Intermediate filament</keyword>
    <keyword evidence="1" id="KW-0416">Keratin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF rod" evidence="7">
        <location>
            <begin position="123"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="204"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="332"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001982.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="507" mass="55739" checksum="C3E237FA390D5F09" modified="2022-01-19" version="1">MSCRSYRISSGCGVTRNFSSCSAVAPKTGNRCCISAAPYRGVSCYRGLTGFGSRSLCNLGPCGPRVAAGGFRAGSCGRSFGYRSGGVCGPSAPCITTVSVNESLLTPLNLEIDPNAQCVKHEEKEQIKCLNSKFAAFIDKVRFLEQQNKLLETKWQFYQNRECCESNLEPLFSGYIETLRREAECVEADSGRLASELNHVQEVLEGYKKRYEEEVALRATAENEFVVLKKDVDCAYLRKSDLEANVEALVEESSFLRRLYEEEIRVLQAHISDTSVIVKMDNSRDLNMDCVVAEIKAQYDDVASRSRAEAESWYRSKCEEMKATVIRHGETLRRTKEEINELNRMVQRLTAEIENAKCQRAKLEAAVAETEQQGEAALNDARCKLAELEAALQKAKQDMACLLKEYQEVMNSKLGLDIEIATYRRLLEGEESRLCEGVGSVNVCVSSSRGGVSCGGLTYSTTPGRQIASGPAATGGCITVTAPDSCSPCQPRSSSFSCGSSRSVRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UNH8</accession>
    <name>A0A8C5UNH8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine/tyrosine interacting like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">STYXL1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UNH8"/>
    <dbReference type="Ensembl" id="ENSMICT00000003931.3">
        <property type="protein sequence ID" value="ENSMICP00000003583.2"/>
        <property type="gene ID" value="ENSMICG00000003929.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010113"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001691">
        <property type="term" value="F:pseudophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062030">
        <property type="term" value="P:negative regulation of stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001244">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000082">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053272">
        <property type="entry name" value="STY_interacting-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46659">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46659:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="1">
        <location>
            <begin position="63"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003583.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="217" mass="25256" checksum="2049900AFCB8555C" modified="2022-01-19" version="1">MADLVMCEPTELYNILNQVTNVSRLTETNYLCLFDVRSKREYDESHVITARRVKKELDAFQPYPVEIVPGRVFLGNFSQACDPKIQKDLKIKAHVNVSMEVGTFFVGDADRLLHIQIEDSPEARIFPFFRHLCHFIEIHIELGSVILIFSTRGISRSCATVVAYLMHQHNQTMKRSWTFVKKCKNNMRPNRGLVIQLLEWEEIVLRNQVTDITDPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UP26</accession>
    <name>A0A8C5UP26_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA replication ATP-dependent helicase/nuclease</fullName>
            <ecNumber evidence="22">3.1.-.-</ecNumber>
            <ecNumber evidence="22">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DNA2</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="22">Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with BLM and WDHD1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="22">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 22">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="22"/>
    <dbReference type="EC" id="3.6.4.12" evidence="22"/>
    <dbReference type="EMBL" id="ABDC03018900">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018902">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018904">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UP26"/>
    <dbReference type="Ensembl" id="ENSMICT00000004377.3">
        <property type="protein sequence ID" value="ENSMICP00000003990.3"/>
        <property type="gene ID" value="ENSMICG00000004377.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00780000122010"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005760">
        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033892">
        <property type="term" value="F:deoxyribonuclease (pyrimidine dimer) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000729">
        <property type="term" value="P:DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033567">
        <property type="term" value="P:DNA replication, Okazaki fragment processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902990">
        <property type="term" value="P:mitotic telomere maintenance via semi-conservative replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045740">
        <property type="term" value="P:positive regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071932">
        <property type="term" value="P:replication fork reversal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000721">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000789">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000915">
        <property type="entry name" value="DNA replication ATP-dependent helicase/nuclease DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048459">
        <property type="entry name" value="DNA2_Rift"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF433">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21123">
        <property type="entry name" value="Dna2_Rift"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 22" id="KW-0227">DNA damage</keyword>
    <keyword evidence="17 22" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="15 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="10 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 22" id="KW-0408">Iron</keyword>
    <keyword evidence="14 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="19 22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 22" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="23">
        <location>
            <begin position="75"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="23">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2 rift barrel" evidence="26">
        <location>
            <begin position="425"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="24">
        <location>
            <begin position="582"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="24">
        <location>
            <begin position="686"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="25">
        <location>
            <begin position="761"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF21123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003990.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1017" mass="115105" checksum="E53EB9EA6E7B0196" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UP58</accession>
    <name>A0A8C5UP58_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thyroglobulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">TG</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="14">Monomer. Homodimer (via ChEL region); occurs in the endoplasmic reticulum and is required for export to the Golgi apparatus. Homooligomer; disulfide-linked; stored in this form in the thyroid follicle lumen.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03013452">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000001044.3">
        <property type="protein sequence ID" value="ENSMICP00000000949.3"/>
        <property type="gene ID" value="ENSMICG00000001039.3"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:iodide transport"/>
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        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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        <property type="entry name" value="CarbesteraseB"/>
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        <property type="entry name" value="Carboxylesterase_B_CS"/>
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        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
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        <property type="entry name" value="HLA CLASS II GAMMA CHAIN"/>
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        <source>
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        <source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UU16</accession>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
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            <taxon>Primates</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03029874">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614363.1">
        <property type="nucleotide sequence ID" value="XM_012758909.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UU16"/>
    <dbReference type="Ensembl" id="ENSMICT00000007864.3">
        <property type="protein sequence ID" value="ENSMICP00000007160.2"/>
        <property type="gene ID" value="ENSMICG00000007869.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868280"/>
    <dbReference type="KEGG" id="mmur:105868280"/>
    <dbReference type="CTD" id="55224"/>
    <dbReference type="GeneTree" id="ENSGT00950000182939"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000002">
        <property type="entry name" value="Ethanolamine kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF94">
        <property type="entry name" value="ETHANOLAMINE KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007160.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="386" mass="44624" checksum="2928D4D311ED0032" modified="2022-01-19" version="1">MAVPPSAPLPRAPLHLRRHAPCPQCSWGMEEKAAASASGREPPGPPRAAAVPCFGIAVDQDDILPGALRLIQELRPHWKPEQVRTKRFTDGITNKLVACYVEEDMRDCVLVRVYGERTELLVDRENEVRNFQLLRAHGCAPKLYCTFQNGLCYEYMQGVALGPEHIREPRLFRLIALEMAKIHTIHANGSLPKPTLWHKMHNYFTLVKNEINPSLSADVPKVEVLEWELAWLKEHLSQLDSPVVFCHNDLLCKNIIYDSTKGHVRFIDYEYAGYNYQAFDIGNHFNEFAGVNEVDYCQYPTRETQLQWLRYYLQAQKGTAVPPREVERLYVQVNKFALASHFFWALWALIQNQYSTIDFDFLRYAVIRFNQYFKVKPQVSALEMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWF8</accession>
    <name>A0A8C5UWF8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Torsin-3A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Torsin family 3 member A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TOR3A</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ClpA/ClpB family. Torsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003417">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UWF8"/>
    <dbReference type="Ensembl" id="ENSMICT00000004400.3">
        <property type="protein sequence ID" value="ENSMICP00000004012.3"/>
        <property type="gene ID" value="ENSMICG00000004404.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182888"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001211">
        <property type="entry name" value="Torsin family 3 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049337">
        <property type="entry name" value="TOR1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010448">
        <property type="entry name" value="Torsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760">
        <property type="entry name" value="TORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10760:SF3">
        <property type="entry name" value="TORSIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21376">
        <property type="entry name" value="TOR1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06309">
        <property type="entry name" value="Torsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034198063" description="Torsin-3A" evidence="12">
        <location>
            <begin position="28"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Torsin-1A C-terminal" evidence="13">
        <location>
            <begin position="336"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004012.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="395" mass="45007" checksum="58B7AD85F6E7D3E9" modified="2022-01-19" version="1">MLPGPRRPSGFGLLLLVLLLLPPPLPAAPGTDEPRSAWAWPGFPRLRERMRAVGDLSKRYWALLRCQVWPDHCEDDGDAAAGPPGWSLPLLGQQYLDVLTTWYCSFQDCCDSGDCRISNNFTGLESDLNVRLHGQHLVQKLVLRTVKDYLETPWPDKALALSFHGWSGTGKNFVARMLAENLYRDGLKSDCVEMFIATVHFAHSQHVDLYKEQLLGRIQETQQLCLQTLFIFDEAEKLHPGLLEVLRPHLERRAPEGHRAKSPRTIFLFLSNLRGNIINEVVLNLLKAGWSREEITMEHLEPHLHAEIVESTDSGFGHSCLVKENLIDYFVPFLPLEYRHVRLCARDAFLSQELQYTEEALDEIATMMAYVPSEEQLFSSQGCKSISQRITYFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWL6</accession>
    <name>A0A8C5UWL6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Disco interacting A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DIP2A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Neuron projection</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DIP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033377">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033379">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140384.1">
        <property type="nucleotide sequence ID" value="XM_020284795.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000008374.3">
        <property type="protein sequence ID" value="ENSMICP00000007624.3"/>
        <property type="gene ID" value="ENSMICG00000047083.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879677"/>
    <dbReference type="CTD" id="23181"/>
    <dbReference type="GeneTree" id="ENSGT00950000182997"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05905">
        <property type="entry name" value="Dip2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000003">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000001">
        <property type="entry name" value="DIP2 disco-interacting protein 2 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000004">
        <property type="entry name" value="Disco interacting protein 2 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000002">
        <property type="entry name" value="Disco interacting protein 2 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037337">
        <property type="entry name" value="Dip2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010506">
        <property type="entry name" value="DMAP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF34">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06464">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01137">
        <property type="entry name" value="DMAP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51912">
        <property type="entry name" value="DMAP1_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DMAP1-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="58"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007624.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1571" mass="169975" checksum="CF8E30315E0903B9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZ12</accession>
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        <submittedName>
            <fullName evidence="2">Polyamine modulated factor 1 binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PMFBP1</name>
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    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZ12"/>
    <dbReference type="Ensembl" id="ENSMICT00000011429.3">
        <property type="protein sequence ID" value="ENSMICP00000010404.3"/>
        <property type="gene ID" value="ENSMICG00000011422.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012700"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061827">
        <property type="term" value="C:sperm head"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037391">
        <property type="entry name" value="PMF1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18881:SF2">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18881">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="194"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="324"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="602"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="695"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010404.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="781" mass="91286" checksum="965CB9A319DC662D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V0B0</accession>
    <name>A0A8C5V0B0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">SUMO-activating enzyme subunit 2</fullName>
            <ecNumber evidence="10">2.3.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">UBA2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8 10">The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.-" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03026977">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630575.1">
        <property type="nucleotide sequence ID" value="XM_012775121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V0B0"/>
    <dbReference type="Ensembl" id="ENSMICT00000011639.3">
        <property type="protein sequence ID" value="ENSMICP00000010591.3"/>
        <property type="gene ID" value="ENSMICG00000011636.3"/>
    </dbReference>
    <dbReference type="CTD" id="10054"/>
    <dbReference type="GeneTree" id="ENSGT00550000074924"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032426">
        <property type="entry name" value="UBA2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16195">
        <property type="entry name" value="UBA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="17">
        <location>
            <begin position="3"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="18">
        <location>
            <begin position="356"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="SUMO-activating enzyme subunit 2 C-terminal" evidence="19">
        <location>
            <begin position="453"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="106"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="455"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11 15">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)" evidence="14">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="14">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate" evidence="14">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="14">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)" evidence="14">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)" evidence="14">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010591.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="544" mass="60714" checksum="B11BDE44BF6202C4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V281</accession>
    <name>A0A8C5V281_MICMU</name>
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        <recommendedName>
            <fullName evidence="3 7">Myc proto-oncogene protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MYC</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release. Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Efficient DNA binding requires dimerization with another bHLH protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03013430">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V281"/>
    <dbReference type="Ensembl" id="ENSMICT00000014980.3">
        <property type="protein sequence ID" value="ENSMICP00000013660.2"/>
        <property type="gene ID" value="ENSMICG00000014990.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155285"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <dbReference type="GO" id="GO:0016604">
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:perinuclear region of cytoplasm"/>
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    <dbReference type="GO" id="GO:0090571">
        <property type="term" value="C:RNA polymerase II transcription repressor complex"/>
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    <dbReference type="GO" id="GO:0005819">
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    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
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    <dbReference type="GO" id="GO:0001228">
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    <dbReference type="GO" id="GO:0140297">
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    <dbReference type="GO" id="GO:0070888">
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    <dbReference type="GO" id="GO:0042802">
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    <dbReference type="GO" id="GO:0001658">
        <property type="term" value="P:branching involved in ureteric bud morphogenesis"/>
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        <property type="term" value="P:cellular response to interferon-alpha"/>
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    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="term" value="P:detection of mechanical stimulus involved in sensory perception of sound"/>
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        <property type="term" value="P:ERK1 and ERK2 cascade"/>
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    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
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    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
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    <dbReference type="GO" id="GO:0042474">
        <property type="term" value="P:middle ear morphogenesis"/>
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    <dbReference type="GO" id="GO:0014902">
        <property type="term" value="P:myotube differentiation"/>
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    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="10">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2K3</accession>
    <name>A0A8C5V2K3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPRY domain containing 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">SPRYD7</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017716">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2K3"/>
    <dbReference type="Ensembl" id="ENSMICT00000012830.3">
        <property type="protein sequence ID" value="ENSMICP00000011689.2"/>
        <property type="gene ID" value="ENSMICG00000012835.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000011048"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
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        <property type="entry name" value="SPRYD7"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035766">
        <property type="entry name" value="SPRYD7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951">
        <property type="entry name" value="C13ORF1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20951:SF2">
        <property type="entry name" value="SPRY DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPRY" evidence="1">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011689.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="157" mass="17425" checksum="79F557541D320F10" modified="2022-01-19" version="1">MAASVLCCLRCCRDGGTGHIPLKEMPAVQLDTQHMGIWGIGVATQKVNLNQIPLGRDVHSLVMRNDGALYHNNEEKNRLPANSLPQEGDVVGITYDHVELNVYLNGKNMHCPASGIRGTVYPVVYVDDSAILDCQFSEFYHTPPPGFEKILFEQQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5G7</accession>
    <name>A0A8C5V5G7_MICMU</name>
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        <recommendedName>
            <fullName evidence="21">Diacylglycerol kinase</fullName>
            <shortName evidence="21">DAG kinase</shortName>
            <ecNumber evidence="21">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">DGKH</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + ATP = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40327"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:74546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:40328"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10273"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="20">Glycerolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; glycerolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03017635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017636">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017637">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017638">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5G7"/>
    <dbReference type="Ensembl" id="ENSMICT00000017492.3">
        <property type="protein sequence ID" value="ENSMICP00000015933.3"/>
        <property type="gene ID" value="ENSMICG00000017492.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158106"/>
    <dbReference type="UniPathway" id="UPA00230"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046473">
        <property type="term" value="P:phosphatidic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141212">
        <property type="term" value="P:phospholipase C/protein kinase C signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030168">
        <property type="term" value="P:platelet activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20848">
        <property type="entry name" value="C1_DGKeta_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20894">
        <property type="entry name" value="C1_DGKeta_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13274">
        <property type="entry name" value="PH_DGK_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000021">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000060">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.40:FF:000001">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000002">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000029">
        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Diacylglycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047480">
        <property type="entry name" value="C1_DGKeta_rpt2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054474">
        <property type="entry name" value="DGKD_4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF37">
        <property type="entry name" value="DIACYLGLYCEROL KINASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22944">
        <property type="entry name" value="DGKD_4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="23">
        <location>
            <begin position="65"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="175"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="234"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="26">
        <location>
            <begin position="315"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="25">
        <location>
            <begin position="1118"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="622"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00060536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015933.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1187" mass="131483" checksum="1859B2C5575BE9B8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V5N1</accession>
    <name>A0A8C5V5N1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kallikrein related peptidase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">KLK12</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1 family. Snake venom subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V5N1"/>
    <dbReference type="Ensembl" id="ENSMICT00000016898.3">
        <property type="protein sequence ID" value="ENSMICP00000015399.2"/>
        <property type="gene ID" value="ENSMICG00000016902.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01020000230389"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030141">
        <property type="term" value="C:secretory granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00190">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000010">
        <property type="entry name" value="Kallikrein related peptidase 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000136">
        <property type="entry name" value="Kallikrein related-peptidase 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001314">
        <property type="entry name" value="Peptidase_S1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001254">
        <property type="entry name" value="Trypsin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018114">
        <property type="entry name" value="TRYPSIN_HIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033116">
        <property type="entry name" value="TRYPSIN_SER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271:SF63">
        <property type="entry name" value="KALLIKREIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24271">
        <property type="entry name" value="KALLIKREIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00089">
        <property type="entry name" value="Trypsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00722">
        <property type="entry name" value="CHYMOTRYPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00020">
        <property type="entry name" value="Tryp_SPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50240">
        <property type="entry name" value="TRYPSIN_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00134">
        <property type="entry name" value="TRYPSIN_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00135">
        <property type="entry name" value="TRYPSIN_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034902107" evidence="7">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S1" evidence="8">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015399.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="252" mass="27293" checksum="A3756D3E3FEE755E" modified="2022-01-19" version="1">MGTSIFLLLCVLGLSHATTLKILNGTECQRNSQPWQVGLFEGTNLRCGGVLIDRRWVLTAAHCSGSRYWVRLGEHSLSQLDWTEQIRRSGFSVTHPSYQGSLKSHEHDLRLLRLGTPVHLTRGVQTLPLPSTCATADTECHISGWGTTNHPWNPFPDRLQCLDLPLVSDDTCRAVYPGRITDNMVCAGGIAGQDACQGDSGGPLVCGGVLQGLVSWGSVGPCGQNGIPGVYTRLPLLLVWGTSWNSNSCQPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VCL4</accession>
    <name>A0A8C5VCL4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">POMT2</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03003909">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003910">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VCL4"/>
    <dbReference type="Ensembl" id="ENSMICT00000017150.3">
        <property type="protein sequence ID" value="ENSMICP00000015622.2"/>
        <property type="gene ID" value="ENSMICG00000017148.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156829"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071711">
        <property type="term" value="P:basement membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021542">
        <property type="term" value="P:dentate gyrus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150103">
        <property type="term" value="P:reactive gliosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23282">
        <property type="entry name" value="beta-trefoil_MIR_POMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000026">
        <property type="entry name" value="Blast:Protein O-mannosyl-transferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="596"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="334"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="464"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015622.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="750" mass="84319" checksum="FDFE693043EBD1B0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VE48</accession>
    <name>A0A8C5VE48_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Myosin heavy chain 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MYH6</name>
        <name evidence="20" type="synonym">LOC105861221</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Muscle contraction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004355">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VE48"/>
    <dbReference type="Ensembl" id="ENSMICT00000054428.2">
        <property type="protein sequence ID" value="ENSMICP00000021229.2"/>
        <property type="gene ID" value="ENSMICG00000045811.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154805"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030016">
        <property type="term" value="C:myofibril"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007512">
        <property type="term" value="P:adult heart development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055009">
        <property type="term" value="P:atrial cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030049">
        <property type="term" value="P:muscle filament sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002027">
        <property type="term" value="P:regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002026">
        <property type="term" value="P:regulation of the force of heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006941">
        <property type="term" value="P:striated muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055010">
        <property type="term" value="P:ventricular cardiac muscle tissue morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
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    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <protein>
        <submittedName>
            <fullName evidence="10">RAD21 cohesin complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">RAD21</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the rad21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606584.1">
        <property type="nucleotide sequence ID" value="XM_012751130.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606585.1">
        <property type="nucleotide sequence ID" value="XM_012751131.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606586.1">
        <property type="nucleotide sequence ID" value="XM_012751132.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJJ7"/>
    <dbReference type="Ensembl" id="ENSMICT00000032090.2">
        <property type="protein sequence ID" value="ENSMICP00000024465.1"/>
        <property type="gene ID" value="ENSMICG00000032869.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105863707"/>
    <dbReference type="KEGG" id="mmur:105863707"/>
    <dbReference type="CTD" id="5885"/>
    <dbReference type="GeneTree" id="ENSGT00940000154655"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030893">
        <property type="term" value="C:meiotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140588">
        <property type="term" value="P:chromatin looping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045841">
        <property type="term" value="P:negative regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045876">
        <property type="term" value="P:positive regulation of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071168">
        <property type="term" value="P:protein localization to chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21792">
        <property type="entry name" value="Rad21_Rec8_M_NXP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.580:FF:000001">
        <property type="entry name" value="double-strand-break repair protein rad21 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049589">
        <property type="entry name" value="NXP1_M-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF20">
        <property type="entry name" value="DOUBLE-STRAND-BREAK REPAIR PROTEIN RAD21 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="8">
        <location>
            <begin position="575"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="451"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="631" mass="71639" checksum="A14DC251DE8BB627" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VL19</accession>
    <name>A0A8C5VL19_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RAB3 GTPase activating non-catalytic protein subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">RAB3GAP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rab3-GAP regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029443">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029444">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029445">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000028560.2">
        <property type="protein sequence ID" value="ENSMICP00000025194.2"/>
        <property type="gene ID" value="ENSMICG00000017747.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005794"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097051">
        <property type="term" value="P:establishment of protein localization to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026059">
        <property type="entry name" value="Rab3GAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029257">
        <property type="entry name" value="RAB3GAP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032839">
        <property type="entry name" value="RAB3GAP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472:SF0">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12472">
        <property type="entry name" value="RAB3-GAP REGULATORY DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14656">
        <property type="entry name" value="RAB3GAP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14655">
        <property type="entry name" value="RAB3GAP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3-GAP regulatory subunit N-terminal" evidence="6">
        <location>
            <begin position="64"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Rab3GAP regulatory subunit C-terminal" evidence="7">
        <location>
            <begin position="759"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025194.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1381" mass="154738" checksum="5EE2C5E7EE6A40A0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VT05</accession>
    <name>A0A8C5VT05_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Erbin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Densin-180-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Erbb2-interacting protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Protein LAP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ERBIN</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Basolateral cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cell junction</location>
            <location evidence="11">Hemidesmosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LAP (LRR and PDZ) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016040">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145593.1">
        <property type="nucleotide sequence ID" value="XM_020290004.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000035953.2">
        <property type="protein sequence ID" value="ENSMICP00000028427.1"/>
        <property type="gene ID" value="ENSMICG00000007584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882030"/>
    <dbReference type="CTD" id="55914"/>
    <dbReference type="GeneTree" id="ENSGT00940000159526"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030056">
        <property type="term" value="C:hemidesmosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070433">
        <property type="term" value="P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098968">
        <property type="term" value="P:neurotransmitter receptor transport postsynaptic membrane to endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098887">
        <property type="term" value="P:neurotransmitter receptor transport, endosome to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043113">
        <property type="term" value="P:receptor clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06749">
        <property type="entry name" value="PDZ_densin_erbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000036">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000013">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000020">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000022">
        <property type="entry name" value="Erbin isoform 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050614">
        <property type="entry name" value="Synaptic_Scaffolding_LAP-MAGUK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119">
        <property type="entry name" value="DISCS LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23119:SF46">
        <property type="entry name" value="ERBB2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ" evidence="17">
        <location>
            <begin position="1211"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="464"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="615"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="802"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="948"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="998"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1073"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1115"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="663"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="817"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1157"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00084015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1302" mass="145984" checksum="D9881946EB594B6B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VU85</accession>
    <name>A0A8C5VU85_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dedicator of cytokinesis 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">DOCK10</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010716">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143762.1">
        <property type="nucleotide sequence ID" value="XM_020288173.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000052378.2">
        <property type="protein sequence ID" value="ENSMICP00000027922.2"/>
        <property type="gene ID" value="ENSMICG00000014003.3"/>
    </dbReference>
    <dbReference type="CTD" id="55619"/>
    <dbReference type="GeneTree" id="ENSGT00940000157469"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001782">
        <property type="term" value="P:B cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060997">
        <property type="term" value="P:dendritic spine morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002315">
        <property type="term" value="P:marginal zone B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030334">
        <property type="term" value="P:regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150052">
        <property type="term" value="P:regulation of postsynapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08697">
        <property type="entry name" value="C2_Dock-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11699">
        <property type="entry name" value="DHR2_DOCK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13267">
        <property type="entry name" value="PH_DOCK-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.740:FF:000001">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000016">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000015">
        <property type="entry name" value="dedicator of cytokinesis protein 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037809">
        <property type="entry name" value="C2_Dock-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021816">
        <property type="entry name" value="DOCK_C/D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23317:SF71">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11878">
        <property type="entry name" value="DOCK_C-D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="240"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="6">
        <location>
            <begin position="731"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="7">
        <location>
            <begin position="1749"/>
            <end position="2209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1349"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1361"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027922.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="2269" mass="259355" checksum="D1A15A06BA6E8C40" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VVA2</accession>
    <name>A0A8C5VVA2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">NUAK2</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03029895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615250.1">
        <property type="nucleotide sequence ID" value="XM_012759796.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VVA2"/>
    <dbReference type="Ensembl" id="ENSMICT00000039498.2">
        <property type="protein sequence ID" value="ENSMICP00000026059.1"/>
        <property type="gene ID" value="ENSMICG00000000056.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868705"/>
    <dbReference type="KEGG" id="mmur:105868705"/>
    <dbReference type="CTD" id="81788"/>
    <dbReference type="GeneTree" id="ENSGT00940000158422"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050321">
        <property type="term" value="F:tau-protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14161">
        <property type="entry name" value="STKc_NUAK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000226">
        <property type="entry name" value="NUAK family SNF1-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF93">
        <property type="entry name" value="NUAK FAMILY SNF1-LIKE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="59"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="365"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="527"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="407"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="636" mass="69590" checksum="8AE73C4919653649" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWL6</accession>
    <name>A0A8C5VWL6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the LARP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007244">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWL6"/>
    <dbReference type="Ensembl" id="ENSMICT00000027078.2">
        <property type="protein sequence ID" value="ENSMICP00000028611.2"/>
        <property type="gene ID" value="ENSMICG00000028052.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154718"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000131">
        <property type="entry name" value="la-related protein 1B isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF50">
        <property type="entry name" value="LA-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="5">
        <location>
            <begin position="154"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028611.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="437" mass="49868" checksum="FA758DA15863DA2C" modified="2022-01-19" version="1">WPTPSELVNTGCQNVISQGNKKLQNRKEKEENVEKRSNNESKENRETASDGPGGSVCEDEAQLWALLHLDDVGPDSQETPGSQSSSRCQPEANKPAHNNRRNDTRNREKRDDQDEVSSVRSEGGNIQGSLRGRGRGRGNPQLNFDYSYGRQVCPVEEALCKEYIKHQIEYYSNTENLEWDFFLQRKMDEQGFLPISLIAGFHRAQALTTNLNLILAALKDSAEVEIMDEKMRKKIEPEKWPIPGPPPRNVPQTDFCQLNDCPEFVPGQAFYSHTESAPNSPRIGSPLSPKKNSETSNLQVMSRGLSTSLPDLDLEPWIELKKRHHLAPVKLKESVPVPKINCSSEEPEQEELDFLFDEEMEQIEGQKNIFTDWSDNDSNYEIDDQDLNKIFLLLPRLEKHPGGDRTVINDGLYYYEQDLWMKEDENKHTAIKVLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZ65</accession>
    <name>A0A8C5VZ65_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">G protein-coupled receptor 37 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">GPR37L1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029836">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599898.1">
        <property type="nucleotide sequence ID" value="XM_012744444.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5VZ65"/>
    <dbReference type="Ensembl" id="ENSMICT00000040197.2">
        <property type="protein sequence ID" value="ENSMICP00000030061.1"/>
        <property type="gene ID" value="ENSMICG00000027500.2"/>
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    <dbReference type="GeneID" id="105860053"/>
    <dbReference type="KEGG" id="mmur:105860053"/>
    <dbReference type="CTD" id="9283"/>
    <dbReference type="GeneTree" id="ENSGT01150000286942"/>
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        <property type="component" value="Chromosome 27"/>
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        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of cerebellar granule cell precursor proliferation"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="7tmA_ETBR-LP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G protein-coupled receptor 37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
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        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="GPR37_orph"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
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    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
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    <feature type="chain" id="PRO_5044150176" evidence="17">
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            <end position="482"/>
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            <end position="102"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZS0</accession>
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        <name evidence="2" type="primary">LOC105871915</name>
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        <name type="common">Gray mouse lemur</name>
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        <lineage>
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            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018015">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000026371.2"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050169">
        <property type="entry name" value="Krueppel_C2H2_ZnF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232">
        <property type="entry name" value="KRAB DOMAIN C2H2 ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23232:SF158">
        <property type="entry name" value="KRAB DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KRAB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030602.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="74" mass="8313" checksum="96823F9A9BFFA630" modified="2022-01-19" version="1">GLLTFRDVAVDFSAEEWACLDPAQQSLHRDVMLENYTNLVSVGLAASERDLVSCLEQRQELWNVKKQDAGATYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W2D9</accession>
    <name>A0A8C5W2D9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ankyrin repeat domain containing 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ANKRD26</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03028174">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028175">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000046375.2">
        <property type="protein sequence ID" value="ENSMICP00000033712.2"/>
        <property type="gene ID" value="ENSMICG00000037016.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162459"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 25"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000208">
        <property type="entry name" value="Ankyrin repeat domain-containing protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050657">
        <property type="entry name" value="Ankyrin_repeat_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039497">
        <property type="entry name" value="CC144C-like_CC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24147:SF60">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14915">
        <property type="entry name" value="CCDC144C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="CCDC144C-like coiled-coil" evidence="7">
        <location>
            <begin position="724"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="726"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="852"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1180"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1256"/>
            <end position="1311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033712.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1336" mass="154308" checksum="A91BD74F99E4AC5B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W327</accession>
    <name>A0A8C5W327_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-iminobutanoate/2-iminopropanoate deaminase</fullName>
            <ecNumber evidence="8">3.5.99.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Reactive intermediate imine deaminase A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Translation inhibitor L-PSP ribonuclease</fullName>
        </alternativeName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex. Acts by bridging YTHDF2 and the ribonuclease P/MRP complex. RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-iminobutanoate + H2O = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:39975"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:76545"/>
            <dbReference type="EC" id="3.5.99.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>2-iminopropanoate + H2O = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:40671"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:44400"/>
            <dbReference type="EC" id="3.5.99.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotrimer. Interacts with YTHDF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.99.10" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03027228">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W327"/>
    <dbReference type="Ensembl" id="ENSMICT00000034643.2">
        <property type="protein sequence ID" value="ENSMICP00000032903.1"/>
        <property type="gene ID" value="ENSMICG00000029505.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029792"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120241">
        <property type="term" value="F:2-iminobutanoate/2-iminopropanoate deaminase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000008">
        <property type="entry name" value="ribonuclease UK114 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF53">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00017859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00080977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="133" mass="14061" checksum="C0182022A8E38DF0" modified="2022-01-19" version="1">MSSLIRSMISTTKAPGAIGPYSQAVLVDKTVYISGQIGMDPSSGQLVPGGVEEAAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNDIYKQYFKSNYPARAAYQVAALPKGGRIEIEAVGPVLYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W543</accession>
    <name>A0A8C5W543_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Sarcosine dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="14">1.5.8.3</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the last step of the oxidative degradation of choline to glycine. Converts sarcosine into glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + sarcosine + oxidized [electron-transfer flavoprotein] + H(+) = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + reduced [electron-transfer flavoprotein] + glycine</text>
            <dbReference type="Rhea" id="RHEA:19793"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="Rhea" id="RHEA-COMP:13257"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57433"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:136572"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="EC" id="1.5.8.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19794"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amine and polyamine degradation; sarcosine degradation; formaldehyde and glycine from sarcosine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.8.3" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03014985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014986">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014987">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014988">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014989">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014990">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014991">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014993">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W543"/>
    <dbReference type="Ensembl" id="ENSMICT00000015402.3">
        <property type="protein sequence ID" value="ENSMICP00000014042.3"/>
        <property type="gene ID" value="ENSMICG00000015394.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000043307.2">
        <property type="protein sequence ID" value="ENSMICP00000031885.2"/>
        <property type="gene ID" value="ENSMICG00000015394.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067440.1">
        <property type="protein sequence ID" value="ENSMICP00000043705.1"/>
        <property type="gene ID" value="ENSMICG00000015394.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157589"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008480">
        <property type="term" value="F:sarcosine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000023">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.9.10:FF:000046">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000769">
        <property type="entry name" value="Sarcosine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000006">
        <property type="entry name" value="Sarcosine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000004">
        <property type="entry name" value="Sarcosine dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF11">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="69"/>
            <end position="427"/>
        </location>
    </feature>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
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                <person name="Gross S."/>
                <person name="Hernandez B."/>
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                <person name="Jones J."/>
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                <person name="Le B."/>
                <person name="Lee S."/>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the mineralization and structural organization of enamel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ameloblastin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029037">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029038">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5D3"/>
    <dbReference type="Ensembl" id="ENSMICT00000053462.2">
        <property type="protein sequence ID" value="ENSMICP00000037102.2"/>
        <property type="gene ID" value="ENSMICG00000033538.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000018227"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030345">
        <property type="term" value="F:structural constituent of tooth enamel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031214">
        <property type="term" value="P:biomineral tissue development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042475">
        <property type="term" value="P:odontogenesis of dentin-containing tooth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007798">
        <property type="entry name" value="Amelin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14115">
        <property type="entry name" value="AMELOBLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14115:SF0">
        <property type="entry name" value="AMELOBLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05111">
        <property type="entry name" value="Amelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00817">
        <property type="entry name" value="Amelin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0091">Biomineralization</keyword>
    <keyword evidence="6" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="10" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034817000" description="Ameloblastin" evidence="12">
        <location>
            <begin position="27"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037102.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="355" mass="37818" checksum="525A930A1967369C" modified="2022-01-19" version="1">MSESKIPLFKMKDLILILCFLHMSVAVPVFPQQSGIPGMASLSLETMRQLGSLQGLNTLSQFSRFGFGKSFNSLWMNGLLPQHSSFPWMRPREHETQQYEYSLPVHPPPLPSQPSLQPQQAGLKPFLQPTAANAIQATEQKGGPQPPAHLGQLPLQEGELPAIQQPAAPSDKPPKPEGGRGGPMAYGAMFPGFGAMRPSFGGLPHNPGMGGDFTLEFDSPLAAATKGPEKGEGGAQDSPILEANPANPENPALLPELAPDAHTGLLAFPEDIDPSLARGPAGQRMGPPSVTPAAADPLMTPELADVYETYGADMTTPLEAVTDTTMTPDPLETSVPGDKAQQPQIVHDAWHFQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEK8</accession>
    <name>A0A8C5XEK8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IZUMO family member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">IZUMO4</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Izumo family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027999">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEK8"/>
    <dbReference type="Ensembl" id="ENSMICT00000015358.3">
        <property type="protein sequence ID" value="ENSMICP00000014002.3"/>
        <property type="gene ID" value="ENSMICG00000015347.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015418"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029389">
        <property type="entry name" value="IZUMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052868">
        <property type="entry name" value="Izumo_fusion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37357">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37357:SF1">
        <property type="entry name" value="IZUMO SPERM-EGG FUSION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15005">
        <property type="entry name" value="IZUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034027810" evidence="3">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014002.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="207" mass="23875" checksum="0569F41BDA70312F" modified="2022-01-19" version="1">MALLLCLGMTAALARGCLHCHNNFSDRFSFYRHHVNLKSWWVGDIPVSGALLTEWSQDTMRELHLAIPAEITREKLEQVARIVYQKMDQLYQGKMYFPGYFPNELRAIFREQVHLIQNAIIESRIDCQRHCGIFQYETISCNNCTDSHVVCFGYNCESSEQWEAAVQGLLSYISDWHNLVSPSFTCLEPQHLANLTLENASECLTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XF40</accession>
    <name>A0A8C5XF40_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="26">Matrix metallopeptidase 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">MMP15</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="19">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="19">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024276">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599419.1">
        <property type="nucleotide sequence ID" value="XM_012743965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XF40"/>
    <dbReference type="Ensembl" id="ENSMICT00000017361.3">
        <property type="protein sequence ID" value="ENSMICP00000015815.2"/>
        <property type="gene ID" value="ENSMICG00000017360.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859800"/>
    <dbReference type="KEGG" id="mmur:105859800"/>
    <dbReference type="CTD" id="4324"/>
    <dbReference type="GeneTree" id="ENSGT00940000156939"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000005">
        <property type="entry name" value="Matrix metallopeptidase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000001">
        <property type="entry name" value="Matrix metallopeptidase 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021805">
        <property type="entry name" value="Pept_M10A_metallopeptidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF25">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11857">
        <property type="entry name" value="DUF3377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
        <property type="entry name" value="HEMOPEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51642">
        <property type="entry name" value="HEMOPEXIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 24" id="KW-0732">Signal</keyword>
    <keyword evidence="5 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="15" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150280" evidence="24">
        <location>
            <begin position="46"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="25">
        <location>
            <begin position="135"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="367"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="416"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="463"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="21">
        <location>
            <begin position="512"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="300"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="565"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="22">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="active site" evidence="17">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="19">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine; by PKDCC" evidence="20">
        <location>
            <position position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001191-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR621190-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015815.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="676" mass="76197" checksum="07B787E33E59CC1F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGD4</accession>
    <name>A0A8C5XGD4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">protein kinase C</fullName>
            <ecNumber evidence="6">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">PKN2</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ heat shock protein family (Hsp40) member C18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DNAJC18</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022480">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604482.1">
        <property type="nucleotide sequence ID" value="XM_012749028.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604483.1">
        <property type="nucleotide sequence ID" value="XM_012749029.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604484.1">
        <property type="nucleotide sequence ID" value="XM_012749030.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604485.1">
        <property type="nucleotide sequence ID" value="XM_012749031.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XGT1"/>
    <dbReference type="Ensembl" id="ENSMICT00000012523.3">
        <property type="protein sequence ID" value="ENSMICP00000011404.1"/>
        <property type="gene ID" value="ENSMICG00000012529.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000046446.2">
        <property type="protein sequence ID" value="ENSMICP00000020851.2"/>
        <property type="gene ID" value="ENSMICG00000012529.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862607"/>
    <dbReference type="KEGG" id="mmur:105862607"/>
    <dbReference type="CTD" id="202052"/>
    <dbReference type="GeneTree" id="ENSGT00940000160925"/>
    <dbReference type="OMA" id="TGQARHY"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000004">
        <property type="entry name" value="DnaJ (Hsp40) homolog, subfamily B, member 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="82"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020851.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="358" mass="41601" checksum="74C73778C99F3F8E" modified="2022-01-19" version="1">MAATLGSGERWTEAYIDAVRRNKYPEDRPPESHDPCGCYNCMKAQKEKKSENERNQTRQGEGNSTYSEEQLLGVQRIKKCRNYYEILGVSRNASDEELKKAYRKLALKFHPDKNCAPGATDAFKAIGNAFAVLSNPDKRLRYDEYGDEQVTFTAPRPRPYNYYRDFEADITPEELFNVFFGGHFPTGNIHMFSNVTDDTRYYRRRHRHERTQTQKEEEEDKPQTTYSAFIQLLPVLVIVVISVITQLLAANPPYSLFYKSALGYTISRETENLQVPYFVDKNFDKAYRGASLRELEKTIEKDYIDYIQTSCWKEKQQKSELTNLAGLYRDERLKQKAESLKLENCEKLSKLTGLRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGX6</accession>
    <name>A0A8C5XGX6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 19">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="4 19">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">MCM4</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="function">
        <text evidence="19">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the MCM2-7 complex. The complex forms a toroidal hexameric ring with the proposed subunit order MCM2-MCM6-MCM4-MCM7-MCM3-MCM5. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex. Interacts with MCMBP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4 19"/>
    <dbReference type="EMBL" id="ABDC03012388">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645484.1">
        <property type="nucleotide sequence ID" value="XM_012790030.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645485.1">
        <property type="nucleotide sequence ID" value="XM_012790031.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XGX6"/>
    <dbReference type="Ensembl" id="ENSMICT00000015643.3">
        <property type="protein sequence ID" value="ENSMICP00000014253.3"/>
        <property type="gene ID" value="ENSMICG00000015638.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039075.2">
        <property type="protein sequence ID" value="ENSMICP00000021250.1"/>
        <property type="gene ID" value="ENSMICG00000015638.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105885242"/>
    <dbReference type="CTD" id="4173"/>
    <dbReference type="GeneTree" id="ENSGT01150000286951"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071162">
        <property type="term" value="C:CMG complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000001">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="21">
        <location>
            <begin position="458"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00062259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="863" mass="96259" checksum="EC996C9C13C84E75" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XIE2</accession>
    <name>A0A8C5XIE2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">RPL32</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027305">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XIE2"/>
    <dbReference type="Ensembl" id="ENSMICT00000050538.2">
        <property type="protein sequence ID" value="ENSMICP00000025677.2"/>
        <property type="gene ID" value="ENSMICG00000034607.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000153973"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025677.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="133" mass="15590" checksum="B636B8AD582241C2" modified="2022-01-19" version="1">MAALRPLVKPKIVKKRTKKFIRHQSDRYVKIKWRKPRGIDNRVRRRFKGQILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAHNVSSKNRKAIVERAAQLAIRVTNPNARLRSEENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XIK6</accession>
    <name>A0A8C5XIK6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LOC105880672</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015468">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XIK6"/>
    <dbReference type="Ensembl" id="ENSMICT00000037166.2">
        <property type="protein sequence ID" value="ENSMICP00000026244.2"/>
        <property type="gene ID" value="ENSMICG00000026970.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005569"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034959704" description="40S ribosomal protein S4" evidence="8">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="60"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026244.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="281" mass="31521" checksum="11AAF391F9AA54D8" modified="2022-01-19" version="1">MFSLLLNSTLALSMLSAAMARGPKKHLKRVAAPKHWMLDKLTGVFAPRPSTGPHKLRECLPLIIFLRNRLKYALTGDEVKKICMQRFIKIDGKVRTDITYPAGFMDVISIDKTGENFRLIYDTKGRFAVHRITPEEAKYKLCKVRKIFVGTKGIPHLVTHDARTIRYPDPLIKVNDTIQIDLETDKITDFIKFDTGNLCMVTGGANLGRIGVITNRERHPGSFDVVHVKDANGNSFATRLSNIFVIGKGNKPWISLPRGKGIRLTIAEERDKRLAAKQSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XN44</accession>
    <name>A0A8C5XN44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TIMM8A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034161">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622870.1">
        <property type="nucleotide sequence ID" value="XM_012767416.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XN44"/>
    <dbReference type="SMR" id="A0A8C5XN44"/>
    <dbReference type="Ensembl" id="ENSMICT00000054538.2">
        <property type="protein sequence ID" value="ENSMICP00000037993.1"/>
        <property type="gene ID" value="ENSMICG00000038724.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105872963"/>
    <dbReference type="KEGG" id="mmur:105872963"/>
    <dbReference type="CTD" id="1678"/>
    <dbReference type="GeneTree" id="ENSGT00940000154661"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000003">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0143">Chaperone</keyword>
    <keyword evidence="11 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="14">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="97" mass="10998" checksum="CB72822290F20AB0" modified="2022-01-19" version="1">MDSSSSSSAAGLGAVDPQLQHFIEVETQKQRFQQLVHQMTELCWEKCMDKPGPKLDSRAEACFVNCVERFIDTSQFILNRLEQTQKSKPVFSESLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQ80</accession>
    <name>A0A8C5XQ80_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Large ribosomal subunit protein uL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">60S ribosomal protein L3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">RPL3</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the large ribosomal subunit. Interacts with DHX33.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008892">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597146.1">
        <property type="nucleotide sequence ID" value="XM_012741692.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQ80"/>
    <dbReference type="Ensembl" id="ENSMICT00000038403.2">
        <property type="protein sequence ID" value="ENSMICP00000039401.2"/>
        <property type="gene ID" value="ENSMICG00000015832.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858511"/>
    <dbReference type="KEGG" id="mmur:105858511"/>
    <dbReference type="CTD" id="6122"/>
    <dbReference type="GeneTree" id="ENSGT00390000017606"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 17" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9 17" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039401.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="403" mass="46137" checksum="BBBC8BA1396E5DDD" modified="2022-01-19" version="1">MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTIFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDEDGKKQLEKDFSSMKKYCQVIRIIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFVMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XT21</accession>
    <name>A0A8C5XT21_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNARE-associated protein Snapin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Biogenesis of lysosome-related organelles complex 1 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SNAPIN</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SNAPIN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646706.1">
        <property type="nucleotide sequence ID" value="XM_012791252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XT21"/>
    <dbReference type="Ensembl" id="ENSMICT00000069179.1">
        <property type="protein sequence ID" value="ENSMICP00000040771.1"/>
        <property type="gene ID" value="ENSMICG00000042295.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105885926"/>
    <dbReference type="KEGG" id="mmur:105885926"/>
    <dbReference type="CTD" id="23557"/>
    <dbReference type="GeneTree" id="ENSGT00390000008274"/>
    <dbReference type="OMA" id="LNMHIRE"/>
    <dbReference type="OrthoDB" id="5399166at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904115">
        <property type="term" value="C:axon cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099078">
        <property type="term" value="C:BORC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002177">
        <property type="term" value="C:manchette"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990742">
        <property type="term" value="C:microvesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048490">
        <property type="term" value="P:anterograde synaptic vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902774">
        <property type="term" value="P:late endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007042">
        <property type="term" value="P:lysosomal lumen acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032418">
        <property type="term" value="P:lysosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070050">
        <property type="term" value="P:neuron cellular homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031503">
        <property type="term" value="P:protein-containing complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000300">
        <property type="term" value="P:regulation of synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008090">
        <property type="term" value="P:retrograde axonal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031629">
        <property type="term" value="P:synaptic vesicle fusion to presynaptic active zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016188">
        <property type="term" value="P:synaptic vesicle maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072553">
        <property type="term" value="P:terminal button organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017246">
        <property type="entry name" value="Snapin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028119">
        <property type="entry name" value="Snapin/Pallidin/Snn1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31305:SF2">
        <property type="entry name" value="SNARE-ASSOCIATED PROTEIN SNAPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14712">
        <property type="entry name" value="Snapin_Pallidin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037631">
        <property type="entry name" value="Snapin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0770">Synapse</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="136" mass="15005" checksum="671AD7A95D63A453" modified="2022-01-19" version="1">MARPGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPSGSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTT9</accession>
    <name>A0A8C5XTT9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Plasma membrane ascorbate-dependent reductase CYBRD1</fullName>
            <ecNumber evidence="15">7.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Cytochrome b reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">CYBRD1</name>
        <name evidence="23" type="synonym">LOC105880718</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66656"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:66657"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Fe(3+)(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + Fe(2+)(out) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30403"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
            <dbReference type="EC" id="7.2.1.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:30404"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>monodehydro-L-ascorbate radical(out) + L-ascorbate(in) = monodehydro-L-ascorbate radical(in) + L-ascorbate(out)</text>
            <dbReference type="Rhea" id="RHEA:66524"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="ChEBI" id="CHEBI:59513"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:66525"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="7.2.1.3" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03011088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTT9"/>
    <dbReference type="Ensembl" id="ENSMICT00000059009.1">
        <property type="protein sequence ID" value="ENSMICP00000041426.1"/>
        <property type="gene ID" value="ENSMICG00000043186.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183197"/>
    <dbReference type="OrthoDB" id="907479at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031526">
        <property type="term" value="C:brush border membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140571">
        <property type="term" value="F:transmembrane ascorbate ferrireductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140576">
        <property type="term" value="P:ascorbate homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060586">
        <property type="term" value="P:multicellular organismal-level iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010039">
        <property type="term" value="P:response to iron ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000001">
        <property type="entry name" value="Cytochrome b reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043205">
        <property type="entry name" value="CYB561/CYBRD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106">
        <property type="entry name" value="CYTOCHROME B561-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10106:SF12">
        <property type="entry name" value="PLASMA MEMBRANE ASCORBATE-DEPENDENT REDUCTASE CYBRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="22">
        <location>
            <begin position="15"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="286" mass="31951" checksum="9EA1979FD2435049" modified="2022-01-19" version="1">MAMDGYKHFLVLLVSALLVGFLSVIFSLVWVLHFRGGLGWDGTDLEFNWHPVFMVTGFVFIQGIAITVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIIALVAVFENRNFRNIPHLYSLHGWVGLIVVIFYILQLLVGFSVFLLPWAPLSLRAFLMPIHVYSGLLLFGTVILTVLMGVTEKLLFTLSNPPYSSFPPEGVFANTLGLLTLVFGALIFWIVTRPQWKRPNEPNSTLLQPNGGTVERVEGSMATSYGHDMDKSDSKLNNEVAARKRNLALDEAVQRSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVL4</accession>
    <name>A0A8C5XVL4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane integral NOTCH2 associated receptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MINAR1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MINAR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013741">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XVL4"/>
    <dbReference type="Ensembl" id="ENSMICT00000059098.1">
        <property type="protein sequence ID" value="ENSMICP00000042170.1"/>
        <property type="gene ID" value="ENSMICG00000041908.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063851"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016525">
        <property type="term" value="P:negative regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030308">
        <property type="term" value="P:negative regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039706">
        <property type="entry name" value="MINAR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009626">
        <property type="entry name" value="MINAR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055117">
        <property type="entry name" value="MINAR1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530:SF2">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31530">
        <property type="entry name" value="MAJOR INTRINSICALLY DISORDERED NOTCH2-BINDING RECEPTOR 1 MINAR1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06789">
        <property type="entry name" value="MINAR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22948">
        <property type="entry name" value="MINAR1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="MINAR1 N-terminal helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Major intrinsically disordered Notch2-binding receptor 1-like C-terminal" evidence="7">
        <location>
            <begin position="748"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="370"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="520"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="693"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="529"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="697"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="734"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="902" mass="96671" checksum="9D57BA5DE5C61F63" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVL6</accession>
    <name>A0A8C5XVL6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XVL6"/>
    <dbReference type="Ensembl" id="ENSMICT00000064871.1">
        <property type="protein sequence ID" value="ENSMICP00000041780.1"/>
        <property type="gene ID" value="ENSMICG00000043092.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="78"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="183" mass="19723" checksum="267188774F589B2F" modified="2022-01-19" version="1">GPELPLVPVKRQRHELQLGGQQGTRGALLPAGPPRCSSLQAPITLLLHPNGSTLAPAGSDRPILLWNVYGDCDNYATLKGHSGAVMELHCDTEAGSMPFSASTDKTVAVWDSETGERGKRLKGQASFLTRRGPQLVRTGSDDHTVKLWGIPIVNGITLLVSFSRCSLLAYRNATNLFYVDFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XY77</accession>
    <name>A0A8C5XY77_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Homeobox B4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">HOXB4</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Antp homeobox family. Deformed subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020107">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621494.1">
        <property type="nucleotide sequence ID" value="XM_012766040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XY77"/>
    <dbReference type="Ensembl" id="ENSMICT00000069231.1">
        <property type="protein sequence ID" value="ENSMICP00000043055.1"/>
        <property type="gene ID" value="ENSMICG00000043173.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872177"/>
    <dbReference type="KEGG" id="mmur:105872177"/>
    <dbReference type="CTD" id="3214"/>
    <dbReference type="GeneTree" id="ENSGT00940000162072"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009952">
        <property type="term" value="P:anterior/posterior pattern specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048539">
        <property type="term" value="P:bone marrow development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060216">
        <property type="term" value="P:definitive hemopoiesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048704">
        <property type="term" value="P:embryonic skeletal system morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060218">
        <property type="term" value="P:hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071425">
        <property type="term" value="P:hematopoietic stem cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002011">
        <property type="term" value="P:morphogenesis of an epithelial sheet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000738">
        <property type="term" value="P:positive regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048103">
        <property type="term" value="P:somatic stem cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048536">
        <property type="term" value="P:spleen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000029">
        <property type="entry name" value="Homeobox protein Hox-D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050609">
        <property type="entry name" value="Antp_homeobox_Deformed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020479">
        <property type="entry name" value="HD_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017995">
        <property type="entry name" value="Homeobox_antennapedia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771:SF3">
        <property type="entry name" value="HOMEOBOX PROTEIN HOX-B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45771">
        <property type="entry name" value="HOMEOTIC PROTEIN DEFORMED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00025">
        <property type="entry name" value="ANTENNAPEDIA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00024">
        <property type="entry name" value="HOMEOBOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="160"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="220"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="251" mass="27618" checksum="B45FE556B8BE84D9" modified="2022-01-19" version="1">MAMSSFLINSNYVDPKFPPCEEYSQSDYLPSDHSPGYYAGGQRRESSFQPEAGFGRRAACTVQRYSACRDPGPPPPPPPPPPPLPPPGLSPRAPAPPPAGALLPEPGQRCEAVSSSPPPPPCAQNPLHPNPSHSACKEPVVYPWMRKVHVSTVNPNYAGGEPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKKDHKLPNTKIRSGGTAGAAGGPPGRPNGGPPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYT2</accession>
    <name>A0A8C5XYT2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Urokinase plasminogen activator surface receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PLAUR</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Invadopodium membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03026721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616708.1">
        <property type="nucleotide sequence ID" value="XM_012761254.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYT2"/>
    <dbReference type="Ensembl" id="ENSMICT00000066630.1">
        <property type="protein sequence ID" value="ENSMICP00000043517.1"/>
        <property type="gene ID" value="ENSMICG00000044642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105869466"/>
    <dbReference type="KEGG" id="mmur:105869466"/>
    <dbReference type="CTD" id="5329"/>
    <dbReference type="GeneTree" id="ENSGT00940000153599"/>
    <dbReference type="OrthoDB" id="5945173at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0098637">
        <property type="term" value="C:protein complex involved in cell-matrix adhesion"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1905370">
        <property type="term" value="C:serine-type endopeptidase complex"/>
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        <property type="term" value="C:side of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:positive regulation of homotypic cell-cell adhesion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd23556">
        <property type="entry name" value="TFP_LU_ECD_uPAR_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23557">
        <property type="entry name" value="TFP_LU_ECD_uPAR_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23558">
        <property type="entry name" value="TFP_LU_ECD_uPAR_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000013">
        <property type="entry name" value="Urokinase plasminogen activator surface receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000015">
        <property type="entry name" value="Urokinase plasminogen activator surface receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.60.10:FF:000019">
        <property type="entry name" value="Urokinase plasminogen activator surface receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10624:SF6">
        <property type="entry name" value="UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10624">
        <property type="entry name" value="UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150410" description="Urokinase plasminogen activator surface receptor" evidence="16">
        <location>
            <begin position="25"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="17">
        <location>
            <begin position="25"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="17">
        <location>
            <begin position="126"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="17">
        <location>
            <begin position="222"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00024905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="343" mass="37400" checksum="F84C576AC182EFF3" modified="2022-01-19" version="1">MGRPLLLLLPPLLLAHTCLPASWGLQCMRCESSGHCQVEECAPGQDLCRTTVMRISEGGLQHDGKQEDELEVVERGCAYPEKTNRTMSYRTGLQIITLTETVCGADFCNRPRPGRRAPSFPRSRSLECVSCASSDMSCERGREQSLQCRSPKEQCLEVVTYRSLEGDLNDEQHTRGCGHLPGCPGPTGFHNNHTFHFLQCCNTTKCNGGPVMELQNLPLNGFQCYSCEGNSTHGCSAEETSLIDCRGPMNQCLEATGTNGPGTPSYTVRGCGTDSWCQRVHVADAFSLTHLNVTCCNGSGCNHPARDVQHRRGGAPRPGPAHLSLTVTLLMTARLWGGTLLWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y0F7</accession>
    <name>A0A8C5Y0F7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phosphodiesterase</fullName>
            <ecNumber evidence="16">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">PDE3A</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>3',5'-cyclic GMP + H2O = GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16957"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57746"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16958"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14653"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57867"/>
            <dbReference type="ChEBI" id="CHEBI:58464"/>
            <dbReference type="EC" id="3.1.4.17"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:14654"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="16">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="16"/>
    <dbReference type="EMBL" id="ABDC03010085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010086">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03010090">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y0F7"/>
    <dbReference type="Ensembl" id="ENSMICT00000006820.3">
        <property type="protein sequence ID" value="ENSMICP00000006215.3"/>
        <property type="gene ID" value="ENSMICG00000006815.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067137.1">
        <property type="protein sequence ID" value="ENSMICP00000044027.1"/>
        <property type="gene ID" value="ENSMICG00000006815.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105882816"/>
    <dbReference type="GeneTree" id="ENSGT00940000156628"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004119">
        <property type="term" value="F:3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047555">
        <property type="term" value="F:3',5'-cyclic-GMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099130">
        <property type="term" value="F:estrogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030284">
        <property type="term" value="F:nuclear estrogen receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097190">
        <property type="term" value="P:apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071321">
        <property type="term" value="P:cellular response to cGMP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071560">
        <property type="term" value="P:cellular response to transforming growth factor beta stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:negative regulation of vascular permeability"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of meiotic nuclear division"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Phosphodiesterase"/>
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        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
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        <property type="entry name" value="HD/PDEase_dom"/>
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        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HD-domain/PDEase-like"/>
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        <property type="entry name" value="PDEASE_I_1"/>
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        <property type="entry name" value="PDEASE_I_2"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="61"/>
            <end position="81"/>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="18">
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    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="240"/>
            <end position="256"/>
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        <location>
            <begin position="678"/>
            <end position="1097"/>
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        <location>
            <begin position="1"/>
            <end position="41"/>
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    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="441"/>
            <end position="460"/>
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            <begin position="522"/>
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            <begin position="524"/>
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            <begin position="612"/>
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            <begin position="1033"/>
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            <begin position="1104"/>
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            <begin position="1129"/>
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            <dbReference type="ARBA" id="ARBA00001936"/>
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    <sequence length="1145" mass="124700" checksum="4A6FE295BA8AB3A1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4D8</accession>
    <name>A0A8C5Y4D8_MICMU</name>
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        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL22m</fullName>
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            <fullName evidence="8">39S ribosomal protein L22, mitochondrial</fullName>
        </alternativeName>
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        <name evidence="10" type="primary">MRPL22</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the universal ribosomal protein uL22 family.</text>
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    <dbReference type="EMBL" id="ABDC03027481">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4D8"/>
    <dbReference type="Ensembl" id="ENSMICT00000061902.1">
        <property type="protein sequence ID" value="ENSMICP00000045644.1"/>
        <property type="gene ID" value="ENSMICG00000029267.2"/>
    </dbReference>
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        <property type="component" value="Chromosome 23"/>
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        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="39S ribosomal protein L22, mitochondrial"/>
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        <property type="entry name" value="Ribosomal protein L22/L17"/>
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        <property type="entry name" value="Ribosomal_uL22"/>
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        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
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        <property type="entry name" value="Ribosomal_uL22_sf"/>
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        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
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        <property type="entry name" value="Ribosomal protein L22"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035286"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="212" mass="24175" checksum="DE0E71CF5EC196FE" modified="2022-01-19" version="1">MAAAVLGQLGTLCIQDLRSRGKLALGFLSSHSVLPQSYIHTSASLDISRRWEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKLIQGMSIDQALAQLEFSDKKGAQIIKEVLLEAQDMAVREHNVEFKSNLYIAVSGSGRGQCLKRIRYHGRGYFGIMEKVYCHYFVKLVEGPPPPREAPKTAVAHAKEYIQELRNRTIIHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y6V5</accession>
    <name>A0A8C5Y6V5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024731">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y6V5"/>
    <dbReference type="Ensembl" id="ENSMICT00000061656.1">
        <property type="protein sequence ID" value="ENSMICP00000047225.1"/>
        <property type="gene ID" value="ENSMICG00000045546.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154293"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000442">
        <property type="entry name" value="Immunoglobulin lambda variable 2-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050150">
        <property type="entry name" value="IgV_Light_Chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23267">
        <property type="entry name" value="IMMUNOGLOBULIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="5" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Immunoglobulin" evidence="9">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin V-set" evidence="8">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10250" checksum="155902AABA1841C1" modified="2022-01-19" version="1">QSALTQPPSVSGAPGQSVTISCSNIKGNYAHWYQQLPGTAPKLLIYDNSKRPSGVPARFSGSKSGSSASLTIAGLQAEDEADYYCHSFLTYNLTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8X1</accession>
    <name>A0A8C5Y8X1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03029516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y8X1"/>
    <dbReference type="Ensembl" id="ENSMICT00000063032.1">
        <property type="protein sequence ID" value="ENSMICP00000047171.1"/>
        <property type="gene ID" value="ENSMICG00000042346.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286916"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="277" mass="32848" checksum="A6EF7AFCE58896C6" modified="2022-01-19" version="1">MGGINMPDIKLYYKAVVIKSIWYWHKNIGIDQWNRSENPDIKPSSYSHLIFDKADKNIHWGKESLFNKWCWENWIATCRRLKQDPHLSPLTKINSCRITDLNLRYETIRILEENVGNTLLDIGLGKEFMKKNRKTITAATKINKWDMIKLKSFCTAKETVMKANRQPTEWEKIFASYTSDKELITRIYLELTKISKKKSNNLIKKWAKDLNRNFSKEDRIMANKHMKKCSTSLIIREMQIKTTMRYHLFPVRMAFIKKSQNNRCWYGCGEIGTLLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YE08</accession>
    <name>A0A8C5YE08_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">A-type voltage-gated potassium channel KCND2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="29">Potassium voltage-gated channel subfamily D member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Voltage-gated potassium channel subunit Kv4.2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="34" type="primary">KCND2</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="34" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="34" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="34" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Perikaryon</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="26">Postsynaptic cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015294">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015295">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015298">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020145345.1">
        <property type="nucleotide sequence ID" value="XM_020289756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YE08"/>
    <dbReference type="Ensembl" id="ENSMICT00000060536.1">
        <property type="protein sequence ID" value="ENSMICP00000049675.1"/>
        <property type="gene ID" value="ENSMICG00000043428.1"/>
    </dbReference>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
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                <person name="Sullivan B."/>
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                <person name="Shamim M."/>
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                <person name="Yoder A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="19"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="204" mass="22659" checksum="486D9A0E57231291" modified="2022-01-19" version="1">SKSTKFQLGWIKNFFGIKPSLFLVGRDIIGLAETGSGKTGAFALPILNALLETPQRLFALVLTPTRELAFQISEQFEALGSSIGVQSAVIVGGIDSMSQSLALAKKPHIVIGELTTWNNTKVMDEAEILNMDFETEVDKILKVIPRDRKTFLFSATMTKKVQKLQRAALKNPVKCAVSSKYQTVEKLQQYYLFIPSKFKVKCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFM1</accession>
    <name>A0A8C5YFM1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Major histocompatibility complex, class II, DM alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">HLA-DMA</name>
        <name evidence="15" type="synonym">LOC105886004</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MHC class II family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007286">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFM1"/>
    <dbReference type="Ensembl" id="ENSMICT00000067677.1">
        <property type="protein sequence ID" value="ENSMICP00000050086.1"/>
        <property type="gene ID" value="ENSMICG00000010132.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161157"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042613">
        <property type="term" value="C:MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023026">
        <property type="term" value="F:MHC class II protein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002503">
        <property type="term" value="P:peptide antigen assembly with MHC class II protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.320.10">
        <property type="entry name" value="Class II Histocompatibility Antigen, M Beta Chain, Chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050160">
        <property type="entry name" value="MHC/Immunoglobulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014745">
        <property type="entry name" value="MHC_II_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001003">
        <property type="entry name" value="MHC_II_a_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944:SF50">
        <property type="entry name" value="HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19944">
        <property type="entry name" value="MHC CLASS II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00993">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00920">
        <property type="entry name" value="MHC_II_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0491">MHC II</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="MHC class II alpha chain N-terminal" evidence="14">
        <location>
            <begin position="83"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Immunoglobulin C1-set" evidence="13">
        <location>
            <begin position="183"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="275" mass="30200" checksum="FEF19440289127FB" modified="2022-01-19" version="1">MTRVTIGNELVKQDLSYPLGAGAGGPGLRGWQVRPAVWREDMAHGQSQGAALLPLLQLLWLLPHSGAFPAAPAPGWRDDTQNHTFLHTVYCQYGSPGVGLSEAYDEDQLFSFDFSRNTRVPRLPEFAKWTEEQSDASAILFDAGFCQMMIQQIGPHLDGKIPVSRGFPVAEVFTMKPLEFGKPNTLVCFVSNLFPPTLTAFSYLNFTPEPSDIFSCMVTHEIDRYTAIAYWVPRNALPSDLLENVLCGVAFGLGVLGIVVGTVLIIYFRKPCSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFV2</accession>
    <name>A0A8C5YFV2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein eS6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </alternativeName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000961">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFV2"/>
    <dbReference type="Ensembl" id="ENSMICT00000072655.1">
        <property type="protein sequence ID" value="ENSMICP00000051073.1"/>
        <property type="gene ID" value="ENSMICG00000049489.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000009819"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="79" mass="8900" checksum="A34342134B91E899" modified="2022-01-19" version="1">MCKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRHLGPQRASRIRKLFNLRVCVTEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EI65</accession>
    <name>A0A8C6EI65_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">single-stranded DNA cytosine deaminase</fullName>
            <ecNumber evidence="9">3.5.4.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC105858492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxycytidine in single-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in single-stranded DNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50948"/>
            <dbReference type="Rhea" id="RHEA-COMP:12846"/>
            <dbReference type="Rhea" id="RHEA-COMP:12847"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:133902"/>
            <dbReference type="EC" id="3.5.4.38"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.38" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03008888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008889">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008890">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EI65"/>
    <dbReference type="Ensembl" id="ENSMICT00000058917.1">
        <property type="protein sequence ID" value="ENSMICP00000044232.1"/>
        <property type="gene ID" value="ENSMICG00000042615.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162695"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016554">
        <property type="term" value="P:cytidine to uridine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070383">
        <property type="term" value="P:DNA cytosine deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045869">
        <property type="term" value="P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000029">
        <property type="entry name" value="DNA dC-&gt;dU-editing enzyme APOBEC-3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050610">
        <property type="entry name" value="APOBEC_Cyt_Deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13857:SF45">
        <property type="entry name" value="DNA DC-DU-EDITING ENZYME APOBEC-3F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13857">
        <property type="entry name" value="MRNA EDITING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18782">
        <property type="entry name" value="NAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="11">
        <location>
            <begin position="50"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="205" mass="24392" checksum="F17E3001A05E7743" modified="2022-01-19" version="1">MERYGARRTARVLQTCPEDCSPNPWIRDPMIRMYPKTFHYHFENRPILYGRYDTWLCFEVKRNDSPVSCGVFRNQEPPKTPCHAEDCFLTWFHDMLSSDQDYQVTWYTSWSPCPVCADDVAGLLAGHGNVTLTICCARLYYYQDPDYQKGLRRMNRNGARLHIMSQEEFKHCWETFVDNQGEPFQPWDGLKEYHQLWNAQLEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKX7</accession>
    <name>A0A8C6EKX7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC105868822</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013950">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144721.1">
        <property type="nucleotide sequence ID" value="XM_020289132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKX7"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
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            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
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                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
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                <person name="Durand N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746">
        <property type="entry name" value="LP21163P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45746:SF3">
        <property type="entry name" value="REGULATOR OF G-PROTEIN SIGNALING 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18148">
        <property type="entry name" value="RGS_DHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="303"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026861.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="467" mass="53174" checksum="16CA13E3D316364D" modified="2022-01-19" version="1">MATGPAPSGGRPREQRPHLSKMERVVVSMQDPDQGVKMRSQRLLITVVPHAVAGGDVVEWLIQKFCIPQEEALHLGTLLVQHGYLYPLRDPGILVLRPDETPYRFQTPYFWTSTLWPAAEMDYAIYLAKKNMRKHGALLDHEKERYVQLHKRINHAWDLVLMQAREQLRAAKRRRKGDRLVIACQEQTFWLVNRPPPGAPNVLEQGPERGCCTASPVQMTKSLDFYKREIERYRKALGRARVKSSVCLEAYLQYSVQHRLHDPILSGCLPGNPWITDNAAYWAVNSPTAAAPTKLRVERWAFSFQELLEDPLGRAHFMDFLGKEFSAENLSFWEACEELRYGGQAQVPALADAAYQQFLAPGAARWVNIDSRTMERTLEGLRQPHRYVLDDAQLHIYMLMKKDSYPRFLKSDLYKGLLAEAGIPLEMKRRVFPFPRKPWHSSPSPAVLPTSGEPMVAGGPGDGDKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EK10</accession>
    <name>A0A8B7EK10_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin-dependent peroxide reductase, mitochondrial</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Thioredoxin-dependent peroxiredoxin 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PRDX3</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Required for the maintenance of physical strength.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer; disulfide-linked, upon oxidation. 6 homodimers assemble to form a ring-like dodecamer. Interacts with NEK6. Interacts with LRRK2. Interacts with MAP3K13. Interacts with RPS6KC1 (via PX domain).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03019464">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594607.1">
        <property type="nucleotide sequence ID" value="XM_012739153.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EK10"/>
    <dbReference type="Ensembl" id="ENSMICT00000007620.3">
        <property type="protein sequence ID" value="ENSMICP00000006933.2"/>
        <property type="gene ID" value="ENSMICG00000007627.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857046"/>
    <dbReference type="KEGG" id="mmur:105857046"/>
    <dbReference type="CTD" id="10935"/>
    <dbReference type="GeneTree" id="ENSGT00940000153430"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043027">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034614">
        <property type="term" value="P:cellular response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001893">
        <property type="term" value="P:maternal placenta development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030099">
        <property type="term" value="P:myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051881">
        <property type="term" value="P:regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032496">
        <property type="term" value="P:response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF128">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="61"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006933.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="254" mass="27729" checksum="7EBA14C236FA5DE9" modified="2022-01-19" version="1">MAAAVCRLLRASVARQVSAIPWGISASASLRPAAVRRTGLTNVLWSGSGQAFSTSSSYQAPAVTQHAPYFKGTAVVNGEFKDLSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFRDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNIALLSDLTKQISRDYGVLLEGPGLALRGLFIIDPNGVIKHLSVNDLPVGRSVEETLRLVKAFQFVEIHGEVCPANWTPDSPTIKPNPTASKEYFEKVNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ELG8</accession>
    <name>A0A8B7ELG8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-galactosidase-1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">GLB1L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Probable glycosyl hydrolase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010755">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595650.1">
        <property type="nucleotide sequence ID" value="XM_012740196.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595651.1">
        <property type="nucleotide sequence ID" value="XM_012740197.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595652.1">
        <property type="nucleotide sequence ID" value="XM_012740198.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ELG8"/>
    <dbReference type="Ensembl" id="ENSMICT00000050916.2">
        <property type="protein sequence ID" value="ENSMICP00000038477.1"/>
        <property type="gene ID" value="ENSMICG00000000795.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857672"/>
    <dbReference type="KEGG" id="mmur:105857672"/>
    <dbReference type="CTD" id="79411"/>
    <dbReference type="GeneTree" id="ENSGT00950000182942"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000021">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000017">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133389" description="Beta-galactosidase-1-like protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="11">
        <location>
            <begin position="38"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="12">
        <location>
            <begin position="400"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="13">
        <location>
            <begin position="537"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="651" mass="74066" checksum="858459E6E5066CBE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EQ70</accession>
    <name>A0A8B7EQ70_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHD finger protein 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">PHF5A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008913">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597159.1">
        <property type="nucleotide sequence ID" value="XM_012741705.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EQ70"/>
    <dbReference type="SMR" id="A0A8B7EQ70"/>
    <dbReference type="Ensembl" id="ENSMICT00000060248.1">
        <property type="protein sequence ID" value="ENSMICP00000042693.1"/>
        <property type="gene ID" value="ENSMICG00000013520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858525"/>
    <dbReference type="KEGG" id="mmur:105858525"/>
    <dbReference type="CTD" id="84844"/>
    <dbReference type="GeneTree" id="ENSGT00390000018518"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048863">
        <property type="term" value="P:stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="110" mass="12405" checksum="90F7469DE7292BF7" modified="2022-01-19" version="1">MAKHHPDLIFCRKQAGVAIGRLCEKCDGKCVICDSYVRPCTLVRICDECNYGSYQGRCVICGGPGVSDAYYCKECTIQEKDRDGCPKIVNLGSSKTDLFYERKKYGFKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ETQ5</accession>
    <name>A0A8B7ETQ5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Choline/ethanolamine transporter FLVCR2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Calcium-chelate transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Feline leukemia virus subgroup C receptor-related protein 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Heme transporter FLVCR2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">FLVCR2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>choline(out) = choline(in)</text>
            <dbReference type="Rhea" id="RHEA:32751"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ethanolamine(in) = ethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:32747"/>
            <dbReference type="ChEBI" id="CHEBI:57603"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>heme b(in) = heme b(out)</text>
            <dbReference type="Rhea" id="RHEA:75443"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597780.1">
        <property type="nucleotide sequence ID" value="XM_012742326.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ETQ5"/>
    <dbReference type="Ensembl" id="ENSMICT00000016062.3">
        <property type="protein sequence ID" value="ENSMICP00000014644.2"/>
        <property type="gene ID" value="ENSMICG00000016055.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858915"/>
    <dbReference type="KEGG" id="mmur:105858915"/>
    <dbReference type="CTD" id="55640"/>
    <dbReference type="GeneTree" id="ENSGT01030000234625"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015220">
        <property type="term" value="F:choline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034228">
        <property type="term" value="F:ethanolamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097037">
        <property type="term" value="P:heme export"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17456">
        <property type="entry name" value="MFS_FLVCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000101">
        <property type="entry name" value="feline leukemia virus subgroup C receptor-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000092">
        <property type="entry name" value="Feline leukemia virus subgroup C receptor-related protein 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF3">
        <property type="entry name" value="HEME TRANSPORTER FLVCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="21">
        <location>
            <begin position="81"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="491"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00080885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="521" mass="56843" checksum="BD7F65B57F85B741" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EX04</accession>
    <name>A0A8B7EX04_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ETS-related transcription factor Elf-3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E74-like factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">ELF3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3. Interacts with ZNF768.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ETS family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599900.1">
        <property type="nucleotide sequence ID" value="XM_012744446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EX04"/>
    <dbReference type="SMR" id="A0A8B7EX04"/>
    <dbReference type="Ensembl" id="ENSMICT00000003168.3">
        <property type="protein sequence ID" value="ENSMICP00000002874.2"/>
        <property type="gene ID" value="ENSMICG00000003167.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860055"/>
    <dbReference type="KEGG" id="mmur:105860055"/>
    <dbReference type="CTD" id="1999"/>
    <dbReference type="GeneTree" id="ENSGT00940000158955"/>
    <dbReference type="OrthoDB" id="5961210at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001824">
        <property type="term" value="P:blastocyst development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060056">
        <property type="term" value="P:mammary gland involution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08537">
        <property type="entry name" value="SAM_PNT-ESE-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000136">
        <property type="entry name" value="ETS homologous factor isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000063">
        <property type="entry name" value="ETS-related transcription factor Elf-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042693">
        <property type="entry name" value="Elf-3_PNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046328">
        <property type="entry name" value="ETS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003118">
        <property type="entry name" value="Pointed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11849:SF13">
        <property type="entry name" value="ETS-RELATED TRANSCRIPTION FACTOR ELF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00178">
        <property type="entry name" value="Ets"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02198">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00454">
        <property type="entry name" value="ETSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00413">
        <property type="entry name" value="ETS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00251">
        <property type="entry name" value="SAM_PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51433">
        <property type="entry name" value="PNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="9 18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0395">Inflammatory response</keyword>
    <keyword evidence="13 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PNT" evidence="21">
        <location>
            <begin position="46"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="20">
        <location>
            <begin position="273"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="171"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="19">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00065911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002874.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="371" mass="41522" checksum="39E9FEE86C049263" modified="2022-01-19" version="1">MAAACQISNVFSNYFSAMYSAEDPALTSAPPAAAFGAEDAELTLGSPQVSLEGTEKASWSGEEPQFWSKAQVLDWISYQVEKHKYDASAIDFSRCNMDGATLCGCALEELRLVFGPLGDQLHAQLRDLTSSPSDELSWIIELLEKDGIAFQEALENPFDQGSPFAQELLEDGQQQASPCHPGSYGAGAPSPGSSDISTTGTGTPQSSHSSDSGGSDVDLDLADSKLFPRDGFPNYKKGDPKHGKRKRGRPRKLSKEYWERLEGKKSKHAPRGTHLWEFIRDILIYPELNQGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNNNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEDEVVQTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EXK7</accession>
    <name>A0A8B7EXK7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Matrix metalloproteinase-25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="primary">MMP25</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">May activate progelatinase A.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="21">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020813">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599327.1">
        <property type="nucleotide sequence ID" value="XM_012743873.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EXK7"/>
    <dbReference type="Ensembl" id="ENSMICT00000030392.2">
        <property type="protein sequence ID" value="ENSMICP00000017963.1"/>
        <property type="gene ID" value="ENSMICG00000028168.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105859759"/>
    <dbReference type="KEGG" id="mmur:105859759"/>
    <dbReference type="CTD" id="64386"/>
    <dbReference type="GeneTree" id="ENSGT00940000159799"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060022">
        <property type="term" value="P:hard palate development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000016">
        <property type="entry name" value="Matrix metallopeptidase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000016">
        <property type="entry name" value="Matrix metallopeptidase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
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        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
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        <property type="entry name" value="Pept_M10_metallopeptidase"/>
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        <property type="entry name" value="Pept_M10A"/>
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        <property type="entry name" value="Peptidase_Metallo"/>
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    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
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        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR10201:SF142">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-25"/>
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        <property type="entry name" value="Hemopexin"/>
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        <property type="entry name" value="Peptidase_M10"/>
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        <property type="entry name" value="PG_binding_1"/>
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        <property type="entry name" value="Peptidase_M10A_matrix"/>
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        <property type="entry name" value="MATRIXIN"/>
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        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
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        <property type="entry name" value="HEMOPEXIN_2"/>
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    <keyword evidence="10 21" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="25" id="KW-0732">Signal</keyword>
    <keyword evidence="9 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
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    <feature type="chain" id="PRO_5044133457" description="Matrix metalloproteinase-25" evidence="25">
        <location>
            <begin position="27"/>
            <end position="561"/>
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    </feature>
    <feature type="domain" description="Peptidase metallopeptidase" evidence="26">
        <location>
            <begin position="114"/>
            <end position="284"/>
        </location>
    </feature>
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        <location>
            <begin position="317"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="23">
        <location>
            <begin position="370"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="23">
        <location>
            <begin position="416"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="Hemopexin" evidence="23">
        <location>
            <begin position="465"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="283"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="492"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cysteine switch" evidence="22">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="24">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" description="in inhibited form" evidence="21">
        <location>
            <position position="93"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
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            <position position="172"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="182"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <label>1</label>
        </ligand>
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            <position position="184"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
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            <position position="189"/>
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    <sequence length="561" mass="62067" checksum="336A1453BC57BFC6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EZ80</accession>
    <name>A0A8B7EZ80_MICMU</name>
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        <recommendedName>
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            <recommendedName>
                <fullName evidence="11">Platelet factor 4</fullName>
                <shortName evidence="11">PF-4</shortName>
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            <alternativeName>
                <fullName evidence="11">C-X-C motif chemokine 4</fullName>
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        <domain>
            <recommendedName>
                <fullName evidence="10">C-X-C motif chemokine</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">LOC105860501</name>
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    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9 11">Homotetramer. Interacts with TNFAIP6 (via Link domain). Interacts with CCR1. Interacts with CXCR3. Interacts with THBD; this interaction enhances generation of activated protein C.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the intercrine alpha (chemokine CxC) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029013">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012745306.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000037082.2">
        <property type="protein sequence ID" value="ENSMICP00000019431.1"/>
        <property type="gene ID" value="ENSMICG00000032999.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860501"/>
    <dbReference type="KEGG" id="mmur:105860501"/>
    <dbReference type="GeneTree" id="ENSGT00940000163368"/>
    <dbReference type="OrthoDB" id="9937393at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008201">
        <property type="term" value="F:heparin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042832">
        <property type="term" value="P:defense response to protozoan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00273">
        <property type="entry name" value="Chemokine_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000004">
        <property type="entry name" value="C-X-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001089">
        <property type="entry name" value="Chemokine_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018048">
        <property type="entry name" value="Chemokine_CXC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033899">
        <property type="entry name" value="CXC_Chemokine_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF211">
        <property type="entry name" value="PLATELET FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00436">
        <property type="entry name" value="INTERLEUKIN8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00437">
        <property type="entry name" value="SMALLCYTKCXC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00471">
        <property type="entry name" value="SMALL_CYTOKINES_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4 10" id="KW-0202">Cytokine</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0358">Heparin-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133462" description="Multifunctional fusion protein" evidence="12">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="13">
        <location>
            <begin position="45"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="108" mass="11009" checksum="ECACA178A8584615" modified="2022-01-19" version="1">MSFPAGAGVAPRAGPGPLLLGLLLLTAAVATSTGASADPAEGAGDLQCLCVKTVSGIPPRLVTSLEVIKAGPHCPTAQLIATLKHGQKICLDQQASRYKKIIKKLLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F4A4</accession>
    <name>A0A8B7F4A4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Vesicle-associated membrane protein 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">Synaptobrevin-like protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">VAMP7</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="24">Cytoplasmic vesicle</location>
            <location evidence="24">Phagosome membrane</location>
            <topology evidence="24">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Cytoplasmic vesicle</location>
            <location evidence="21">Secretory vesicle membrane</location>
            <topology evidence="21">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Golgi apparatus</location>
            <location evidence="20">trans-Golgi network membrane</location>
            <topology evidence="20">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Late endosome membrane</location>
            <topology evidence="22">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Lysosome membrane</location>
            <topology evidence="23">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Synapse</location>
            <location evidence="18">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035588">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602410.1">
        <property type="nucleotide sequence ID" value="XM_012746956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F4A4"/>
    <dbReference type="Ensembl" id="ENSMICT00000028928.2">
        <property type="protein sequence ID" value="ENSMICP00000029401.1"/>
        <property type="gene ID" value="ENSMICG00000001581.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861465"/>
    <dbReference type="KEGG" id="mmur:105861465"/>
    <dbReference type="CTD" id="6845"/>
    <dbReference type="GeneTree" id="ENSGT00510000047733"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030658">
        <property type="term" value="C:transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15871">
        <property type="entry name" value="R-SNARE_VAMP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000006">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF179">
        <property type="entry name" value="VESICLE ASSOCIATED MEMBRANE PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 27" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="16" id="KW-0458">Lysosome</keyword>
    <keyword evidence="15 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="5" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="6 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="29">
        <location>
            <begin position="7"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="30">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00037328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00037845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00037863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00037875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00039269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00042194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="220" mass="24939" checksum="EA6885FB4B47C29E" modified="2022-01-19" version="1">MAILFAVVARGTTILAKHAWCGGNFLEVTEQILAKIPSENNKLTYSHGNYLFHYICQDRIVYLCITDDDFERSRAFNFMNEIKKRFQTTYGSRAQTALPYAMNSEFSSVLAAQLKHHSENKGLDKVMETQAQVDELKGIMVRNIDLVAQRGERLELLIDKTENLVDSSVTFKTTSRNLAQAMCMKNLKLTIIIIIISIVFIYIIVSPLCGGFTWPSCVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F8H6</accession>
    <name>A0A8B7F8H6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat and BTB domain containing 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">KBTBD3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03006793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604205.1">
        <property type="nucleotide sequence ID" value="XM_012748751.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604206.1">
        <property type="nucleotide sequence ID" value="XM_012748752.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F8H6"/>
    <dbReference type="Ensembl" id="ENSMICT00000059524.1">
        <property type="protein sequence ID" value="ENSMICP00000046741.1"/>
        <property type="gene ID" value="ENSMICG00000030981.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105862469"/>
    <dbReference type="KEGG" id="mmur:105862469"/>
    <dbReference type="CTD" id="143879"/>
    <dbReference type="GeneTree" id="ENSGT00940000158415"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd18480">
        <property type="entry name" value="BACK_KBTBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18271">
        <property type="entry name" value="BTB_POZ_KBTBD3_BKLHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.420:FF:000001">
        <property type="entry name" value="Kelch-like family member 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011705">
        <property type="entry name" value="BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017096">
        <property type="entry name" value="BTB-kelch_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030589">
        <property type="entry name" value="BTB/POZ_KBTBD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047062">
        <property type="entry name" value="KBTBD3_BACK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF418">
        <property type="entry name" value="KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07707">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037037">
        <property type="entry name" value="Kelch-like_protein_gigaxonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00875">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="52"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="611" mass="69874" checksum="EE46F1B2A29CE067" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FIE4</accession>
    <name>A0A8B7FIE4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">SLC9A6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Recycling endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035022">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012607784.1">
        <property type="nucleotide sequence ID" value="XM_012752330.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FIE4"/>
    <dbReference type="Ensembl" id="ENSMICT00000011755.3">
        <property type="protein sequence ID" value="ENSMICP00000010701.3"/>
        <property type="gene ID" value="ENSMICG00000011746.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105864446"/>
    <dbReference type="CTD" id="10479"/>
    <dbReference type="GeneTree" id="ENSGT00940000153460"/>
    <dbReference type="OrthoDB" id="196264at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043679">
        <property type="term" value="C:axon terminus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044308">
        <property type="term" value="C:axonal spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
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        <property type="term" value="F:potassium:proton antiporter activity"/>
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        <property type="term" value="F:sodium:proton antiporter activity"/>
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        <property type="term" value="P:brain-derived neurotrophic factor receptor signaling pathway"/>
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        <property type="term" value="P:dendritic spine development"/>
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        <property type="term" value="P:regulation of intracellular pH"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:regulation of neurotrophin TRK receptor signaling pathway"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099072">
        <property type="term" value="P:regulation of postsynaptic membrane neurotransmitter receptor levels"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050808">
        <property type="term" value="P:synapse organization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002090">
        <property type="entry name" value="NHE-6/7/9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF94">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01088">
        <property type="entry name" value="NAHEXCHNGR6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="10 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133623" description="Sodium/hydrogen exchanger" evidence="15">
        <location>
            <begin position="43"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="16">
        <location>
            <begin position="84"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007367"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023053"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003722"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010701.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="701" mass="77775" checksum="F4C84C99A1133227" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FVQ3</accession>
    <name>A0A8B7FVQ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">E3 ubiquitin-protein ligase TRIM9</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">RING-type E3 ubiquitin transferase TRIM9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Tripartite motif-containing protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="primary">TRIM9</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="32" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="32" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="32" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21">Interacts with SNAP25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell projection</location>
            <location evidence="4">Dendrite</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Synaptic vesicle</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03004254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004256">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613409.1">
        <property type="nucleotide sequence ID" value="XM_012757955.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FVQ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000054473.2">
        <property type="protein sequence ID" value="ENSMICP00000025279.1"/>
        <property type="gene ID" value="ENSMICG00000013634.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867673"/>
    <dbReference type="KEGG" id="mmur:105867673"/>
    <dbReference type="CTD" id="114088"/>
    <dbReference type="GeneTree" id="ENSGT00940000154071"/>
    <dbReference type="OrthoDB" id="295536at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008021">
        <property type="term" value="C:synaptic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19843">
        <property type="entry name" value="Bbox1_TRIM9_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19826">
        <property type="entry name" value="Bbox2_TRIM9_C-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16755">
        <property type="entry name" value="RING-HC_TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12889">
        <property type="entry name" value="SPRY_PRY_TRIM67_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000009">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000178">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000168">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.40:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000329">
        <property type="entry name" value="E3 ubiquitin-protein ligase TRIM9 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000017">
        <property type="entry name" value="Putative E3 ubiquitin-protein ligase TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003649">
        <property type="entry name" value="Bbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017903">
        <property type="entry name" value="COS_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049582">
        <property type="entry name" value="TRIM9_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
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        <property type="entry name" value="Znf_B-box"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
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        <property type="entry name" value="SPRY"/>
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    <dbReference type="Pfam" id="PF00643">
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        <property type="entry name" value="zf-RING_UBOX"/>
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        <property type="entry name" value="BBC"/>
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        <property type="entry name" value="RING"/>
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        <property type="entry name" value="B-box zinc-binding domain"/>
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    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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        <property type="entry name" value="Fibronectin type III"/>
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    <keyword evidence="19" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17 26" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="13" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="14" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="27">
        <location>
            <begin position="10"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="28">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="28">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="COS" evidence="31">
        <location>
            <begin position="374"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="30">
        <location>
            <begin position="440"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="29">
        <location>
            <begin position="517"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="26">
        <location>
            <begin position="288"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00061782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00074095"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079716"/>
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    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00083989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
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    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
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    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
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    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS51262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025279.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="710" mass="79251" checksum="717464D79D15CBF3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FY76</accession>
    <name>A0A8B7FY76_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COPS6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614449.1">
        <property type="nucleotide sequence ID" value="XM_012758995.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FY76"/>
    <dbReference type="Ensembl" id="ENSMICT00000026436.2">
        <property type="protein sequence ID" value="ENSMICP00000021048.1"/>
        <property type="gene ID" value="ENSMICG00000003965.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868308"/>
    <dbReference type="KEGG" id="mmur:105868308"/>
    <dbReference type="CTD" id="10980"/>
    <dbReference type="GeneTree" id="ENSGT00950000183073"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000017">
        <property type="entry name" value="COP9 signalosome complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="40"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="36078" checksum="FABEA4D023014353" modified="2022-01-19" version="1">MAAAAAAAAANGTGGSSGMEVDAAVVPSVMASGVTGSVSVALHPLVILNISDHWIRMRSQEGRPMQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G257</accession>
    <name>A0A8B7G257_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Gamma-aminobutyric acid type A receptor subunit alpha5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">GABRA5</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>chloride(in) = chloride(out)</text>
            <dbReference type="Rhea" id="RHEA:29823"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Postsynaptic cell membrane</location>
            <topology evidence="18">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615732.1">
        <property type="nucleotide sequence ID" value="XM_012760278.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615733.1">
        <property type="nucleotide sequence ID" value="XM_012760279.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615734.1">
        <property type="nucleotide sequence ID" value="XM_012760280.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615735.1">
        <property type="nucleotide sequence ID" value="XM_012760281.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615736.1">
        <property type="nucleotide sequence ID" value="XM_012760282.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G257"/>
    <dbReference type="Ensembl" id="ENSMICT00000000032.3">
        <property type="protein sequence ID" value="ENSMICP00000000030.2"/>
        <property type="gene ID" value="ENSMICG00000000032.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065897.1">
        <property type="protein sequence ID" value="ENSMICP00000046313.1"/>
        <property type="gene ID" value="ENSMICG00000000032.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868903"/>
    <dbReference type="KEGG" id="mmur:105868903"/>
    <dbReference type="CTD" id="2558"/>
    <dbReference type="GeneTree" id="ENSGT00940000156234"/>
    <dbReference type="OrthoDB" id="203862at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044297">
        <property type="term" value="C:cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004890">
        <property type="term" value="F:GABA-A receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022851">
        <property type="term" value="F:GABA-gated chloride ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099507">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008306">
        <property type="term" value="P:associative learning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090102">
        <property type="term" value="P:cochlea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007214">
        <property type="term" value="P:gamma-aminobutyric acid signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060119">
        <property type="term" value="P:inner ear receptor cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19038">
        <property type="entry name" value="LGIC_ECD_GABAAR_A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19052">
        <property type="entry name" value="LGIC_TM_GABAAR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000001">
        <property type="entry name" value="Gamma-aminobutyric acid A receptor subunit alpha-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000002">
        <property type="entry name" value="Putative gamma-aminobutyric acid receptor subunit alpha-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006028">
        <property type="entry name" value="GABAA/Glycine_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001390">
        <property type="entry name" value="GABAAa_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005435">
        <property type="entry name" value="GABBAa5_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047024">
        <property type="entry name" value="Gabra-1-6_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01079">
        <property type="entry name" value="GABAARALPHA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01618">
        <property type="entry name" value="GABAARALPHA5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00253">
        <property type="entry name" value="GABAARECEPTR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 19" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 19" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 19" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 19" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044519623" evidence="19">
        <location>
            <begin position="26"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="21">
        <location>
            <begin position="50"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="22">
        <location>
            <begin position="264"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="462" mass="52170" checksum="9566AE766A0798AD" modified="2022-01-19" version="1">MDNGMFSSFIMIKNLLLFCISMNLSSHFGFSQMPTSSGKDETNDNITIFTRILDGLLDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIKKKERELILKKSTNAFTTGKMTHPPNIPKEQTPAGTSNASSVSVKPEEKPSESKKTYNSISKIDKMSRIVFPVLFGTFNLVYWATYLNREPVIKGAASPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G472</accession>
    <name>A0A8B7G472_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">AP2S1</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Interacts with CCDC32; the interaction is direct and mediates association of CCDC32 with adaptor protein complex 2 (AP-2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026760">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616959.1">
        <property type="nucleotide sequence ID" value="XM_012761505.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G472"/>
    <dbReference type="SMR" id="A0A8B7G472"/>
    <dbReference type="Ensembl" id="ENSMICT00000038115.2">
        <property type="protein sequence ID" value="ENSMICP00000019384.1"/>
        <property type="gene ID" value="ENSMICG00000038528.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869576"/>
    <dbReference type="KEGG" id="mmur:105869576"/>
    <dbReference type="CTD" id="1175"/>
    <dbReference type="GeneTree" id="ENSGT00970000193421"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030122">
        <property type="term" value="C:AP-2 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14833">
        <property type="entry name" value="AP2_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000004">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027156">
        <property type="entry name" value="APS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000804">
        <property type="entry name" value="Clathrin_sm-chain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00989">
        <property type="entry name" value="CLAT_ADAPTOR_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0168">Coated pit</keyword>
    <keyword evidence="6" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="12">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="142" mass="17018" checksum="CA3FD868C65AEDF6" modified="2022-01-19" version="1">MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEFRNFKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVLKQLLMLQSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8A8</accession>
    <name>A0A8B7G8A8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPS7</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618623.1">
        <property type="nucleotide sequence ID" value="XM_012763169.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8A8"/>
    <dbReference type="SMR" id="A0A8B7G8A8"/>
    <dbReference type="Ensembl" id="ENSMICT00000053100.2">
        <property type="protein sequence ID" value="ENSMICP00000020556.1"/>
        <property type="gene ID" value="ENSMICG00000031923.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105870524"/>
    <dbReference type="KEGG" id="mmur:105870524"/>
    <dbReference type="CTD" id="6201"/>
    <dbReference type="GeneTree" id="ENSGT00390000014122"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990948">
        <property type="term" value="F:ubiquitin ligase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000059">
        <property type="term" value="P:negative regulation of ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014033">
        <property type="term" value="P:neural crest cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001843">
        <property type="term" value="P:neural tube closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902255">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="194" mass="22127" checksum="E21089929CC061E9" modified="2022-01-19" version="1">MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GDW4</accession>
    <name>A0A8B7GDW4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Tyrosine-protein kinase</fullName>
            <ecNumber evidence="21">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="primary">LCK</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 27">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the protein kinase superfamily. Tyr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03001596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001597">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620863.1">
        <property type="nucleotide sequence ID" value="XM_012765409.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GDW4"/>
    <dbReference type="Ensembl" id="ENSMICT00000032644.2">
        <property type="protein sequence ID" value="ENSMICP00000030658.1"/>
        <property type="gene ID" value="ENSMICG00000017802.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000047788.2">
        <property type="protein sequence ID" value="ENSMICP00000024325.1"/>
        <property type="gene ID" value="ENSMICG00000017802.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871813"/>
    <dbReference type="KEGG" id="mmur:105871813"/>
    <dbReference type="CTD" id="3932"/>
    <dbReference type="GeneTree" id="ENSGT00940000161163"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004715">
        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038094">
        <property type="term" value="P:Fc-gamma receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002429">
        <property type="term" value="P:immune response-activating cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050900">
        <property type="term" value="P:leukocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051240">
        <property type="term" value="P:positive regulation of multicellular organismal process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05067">
        <property type="entry name" value="PTKc_Lck_Blk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10362">
        <property type="entry name" value="SH2_Src_Lck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12005">
        <property type="entry name" value="SH3_Lck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000553">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000152">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000036">
        <property type="entry name" value="Tyrosine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000077">
        <property type="entry name" value="Tyrosine-protein kinase Lck"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035850">
        <property type="entry name" value="Lck_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035749">
        <property type="entry name" value="Lck_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050198">
        <property type="entry name" value="Non-receptor_tyrosine_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000980">
        <property type="entry name" value="SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24418">
        <property type="entry name" value="TYROSINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00017">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00401">
        <property type="entry name" value="SH2DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00252">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50001">
        <property type="entry name" value="SH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 18" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="3 19" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 21" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="SH3" evidence="23">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="SH2" evidence="22">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="245"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="509" mass="58066" checksum="49192A27050D7B4C" modified="2022-01-19" version="1">MGCGCSSNPEDDWMENIDVCENCHYPIVPLDGKATLPMRNGSEVRDPLVTYEGSNPPASPMQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDKGGFYISPRITFTSLHELVRHYTNTPDGLCTRLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPPGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVQPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GDX8</accession>
    <name>A0A8B7GDX8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eva-1 homolog B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EVA1B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EVA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001663">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620667.1">
        <property type="nucleotide sequence ID" value="XM_012765213.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620668.1">
        <property type="nucleotide sequence ID" value="XM_012765214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GDX8"/>
    <dbReference type="Ensembl" id="ENSMICT00000070311.1">
        <property type="protein sequence ID" value="ENSMICP00000044552.1"/>
        <property type="gene ID" value="ENSMICG00000044326.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105871740"/>
    <dbReference type="KEGG" id="mmur:105871740"/>
    <dbReference type="CTD" id="55194"/>
    <dbReference type="GeneTree" id="ENSGT00940000154096"/>
    <dbReference type="OMA" id="ISCAPHP"/>
    <dbReference type="OrthoDB" id="8956386at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052461">
        <property type="entry name" value="EVA1_A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039500">
        <property type="entry name" value="EVA1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422:SF2">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48422">
        <property type="entry name" value="PROTEIN EVA-1 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14851">
        <property type="entry name" value="FAM176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="EVA1" evidence="8">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="166" mass="18278" checksum="4E835ECA2746D18E" modified="2022-01-19" version="1">MDAPRRDMELLSNSLAAYAHIRANPESLGLYFVLGVCFGLLLTLCLLVISISCAPRPRPRGPSLRRGARSSTLEPEEDEDEEEEDTVTRLGPDDTLAGPELSAEPDGPLSVNVFTSAEELERAQRLEERERILREIWRTGQPDLLGTGTLGPSPTATGTLGRMHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GJ44</accession>
    <name>A0A8B7GJ44_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome 1 open reading frame 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C1orf54</name>
        <name evidence="2" type="synonym">C2H1orf54</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003006">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GJ44"/>
    <dbReference type="Ensembl" id="ENSMICT00000015338.3">
        <property type="protein sequence ID" value="ENSMICP00000013984.3"/>
        <property type="gene ID" value="ENSMICG00000015318.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003103"/>
    <dbReference type="OrthoDB" id="9834409at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001013">
        <property type="term" value="P:epithelial cell proliferation involved in renal tubule morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027957">
        <property type="entry name" value="DUF4634"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37870">
        <property type="entry name" value="CHROMOSOME 1 OPEN READING FRAME 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37870:SF1">
        <property type="entry name" value="CHROMOSOME 2 C1ORF54 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15465">
        <property type="entry name" value="DUF4634"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133863" evidence="1">
        <location>
            <begin position="17"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013984.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="131" mass="14977" checksum="0634EC6A9367BB90" modified="2022-01-19" version="1">MDVLLVAILAVPLILGQEYEDEESLEEDDYYQVVYYYTVTPSYDDFGANFTIDYSMFESEDRLNRLDQKVTEAVETTTSLETERADHQKPITVKPVIMETSPDLNDAVSGLQSPVSLLLWWALVQGGMYFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GMG3</accession>
    <name>A0A8B7GMG3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C1q domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">LOC105873601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03009155">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624128.1">
        <property type="nucleotide sequence ID" value="XM_012768674.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GMG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000061215.1">
        <property type="protein sequence ID" value="ENSMICP00000050260.1"/>
        <property type="gene ID" value="ENSMICG00000045713.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873601"/>
    <dbReference type="KEGG" id="mmur:105873601"/>
    <dbReference type="GeneTree" id="ENSGT00900000141239"/>
    <dbReference type="OrthoDB" id="9620672at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001073">
        <property type="entry name" value="C1q_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050392">
        <property type="entry name" value="Collagen/C1q_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008983">
        <property type="entry name" value="Tumour_necrosis_fac-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427">
        <property type="entry name" value="EMILIN ELASTIN MICROFIBRIL INTERFACE-LOCATED PROTEIN ELASTIN MICROFIBRIL INTERFACER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15427:SF34">
        <property type="entry name" value="PROTEIN HP-25 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00386">
        <property type="entry name" value="C1q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00007">
        <property type="entry name" value="COMPLEMNTC1Q"/>
    </dbReference>
    <dbReference type="SMART" id="SM00110">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49842">
        <property type="entry name" value="TNF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50871">
        <property type="entry name" value="C1Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133898" description="C1q domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="C1q" evidence="6">
        <location>
            <begin position="82"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="217" mass="23354" checksum="780503D8983B84DF" modified="2022-01-19" version="1">MHRAGERGLALGIVDVWMLSLSVVSAMAEVNSPETSKPCDSRGLPGVPGPPGFAGVPGPTGPPGYSGPPGAPGTPGDIEQCSSLPQTAFAVKLSDPLPAPSQPIVFKEVLHNHQDRFSLTSGVFTCINPGVYHFGFDIELFQHALKLGLMKNGIQVLEKEAEAKGMYRHVSGTVILQLMVGDRVWLESKLDTKENEKGLIQTIFFGYLLYGNYIDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GMR4</accession>
    <name>A0A8B7GMR4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sorting nexin-30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SNX30</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Heterodimer; heterodimerizes with SNX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014828">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624372.1">
        <property type="nucleotide sequence ID" value="XM_012768918.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GMR4"/>
    <dbReference type="Ensembl" id="ENSMICT00000001130.3">
        <property type="protein sequence ID" value="ENSMICP00000001028.2"/>
        <property type="gene ID" value="ENSMICG00000001131.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873721"/>
    <dbReference type="CTD" id="401548"/>
    <dbReference type="GeneTree" id="ENSGT00940000158994"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000786">
        <property type="term" value="P:positive regulation of autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07667">
        <property type="entry name" value="BAR_SNX30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06860">
        <property type="entry name" value="PX_SNX7_30_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028649">
        <property type="entry name" value="SNX30_BAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF1">
        <property type="entry name" value="SORTING NEXIN-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="89"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001028.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="437" mass="49635" checksum="F70B675EA8254BB8" modified="2022-01-19" version="1">MAGGPPKALPSTGPHSLRDMPHPLAGSSSEEAVGGDSTPSPDLLMGRSFGDKDLILPNGGTPAGTSSPASSSSLLNRLQLDDDIDGETRDLFVTVDDPKKHVCTMETYITYRITTKSTRVEFDLPEYSVRRRYQDFDWLRNKLEESQPTHLIPPLPEKFVVKGVVDRFSEEFVETRRKALDKFLKRITDHPVLSFNEHFNVFLTAKDLNAYKKQGMALLTRVGESVKHVTGGYKLRTRPLEFAAIGDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGVSGCIGNCSTALEELTDDMTEDFLPVLREYILYSDSMKSVLKKRDQVQAEYEAKLEAVALRKEERPKVPADVEKCQDRMECFNADLKADMERWQNNKRQDFRQLLMGMADKNIQYYEKCLMAWESVIPLLQEKQEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GPA2</accession>
    <name>A0A8B7GPA2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">TIMM13</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer; composed of 3 copies of TIMM8 (TIMM8A or TIMM8B) and 3 copies of TIMM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIMM22.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion inner membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028003">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624845.1">
        <property type="nucleotide sequence ID" value="XM_012769391.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GPA2"/>
    <dbReference type="SMR" id="A0A8B7GPA2"/>
    <dbReference type="Ensembl" id="ENSMICT00000053808.2">
        <property type="protein sequence ID" value="ENSMICP00000031882.1"/>
        <property type="gene ID" value="ENSMICG00000026616.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873986"/>
    <dbReference type="KEGG" id="mmur:105873986"/>
    <dbReference type="CTD" id="26517"/>
    <dbReference type="GeneTree" id="ENSGT00390000014000"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00064371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="95" mass="10500" checksum="E40E742C7CA55834" modified="2022-01-19" version="1">MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTDKCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GTB7</accession>
    <name>A0A8B7GTB7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RAB22A, member RAS onco family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RAB22A</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Phagosome membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021953">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625914.1">
        <property type="nucleotide sequence ID" value="XM_012770460.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GTB7"/>
    <dbReference type="Ensembl" id="ENSMICT00000027215.2">
        <property type="protein sequence ID" value="ENSMICP00000023979.1"/>
        <property type="gene ID" value="ENSMICG00000008382.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874529"/>
    <dbReference type="CTD" id="57403"/>
    <dbReference type="GeneTree" id="ENSGT00940000157009"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000346">
        <property type="entry name" value="RAB31, member RAS oncogene family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="194" mass="21839" checksum="EBC84711DA2B82DB" modified="2022-01-19" version="1">MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVKELRQHGPPNIVVAIAGNKCDLIDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANPPSGGKGFKLRRQPSEPKRSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H4D3</accession>
    <name>A0A8B7H4D3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Centrobin, centriole duplication and spindle assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CNTROB</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03020548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631201.1">
        <property type="nucleotide sequence ID" value="XM_012775747.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H4D3"/>
    <dbReference type="Ensembl" id="ENSMICT00000008878.3">
        <property type="protein sequence ID" value="ENSMICP00000008083.2"/>
        <property type="gene ID" value="ENSMICG00000008866.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877340"/>
    <dbReference type="KEGG" id="mmur:105877340"/>
    <dbReference type="CTD" id="116840"/>
    <dbReference type="GeneTree" id="ENSGT00610000086191"/>
    <dbReference type="OrthoDB" id="8190486at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019904">
        <property type="term" value="F:protein domain specific binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051299">
        <property type="term" value="P:centrosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902410">
        <property type="term" value="P:mitotic cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902017">
        <property type="term" value="P:regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038923">
        <property type="entry name" value="Centrobin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34439:SF1">
        <property type="entry name" value="CENTROBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="570"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="642"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="841"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="782"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008083.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="907" mass="101863" checksum="669F13CA476B4565" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H8T6</accession>
    <name>A0A8B7H8T6_MICMU</name>
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        <recommendedName>
            <fullName evidence="10">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">POU6F2</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the POU transcription factor family. Class-6 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015747">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015748">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015749">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012777600.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000050288.2">
        <property type="protein sequence ID" value="ENSMICP00000028581.1"/>
        <property type="gene ID" value="ENSMICG00000007361.3"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000051">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF68">
        <property type="entry name" value="POU DOMAIN, CLASS 6, TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="13">
        <location>
            <begin position="480"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="609"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="611"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="190"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="200"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061425"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028581.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="695" mass="73620" checksum="216519C83B695831" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HAF5</accession>
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            <fullName evidence="3">Elongation factor 1-gamma</fullName>
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            <fullName evidence="6">eEF-1B gamma</fullName>
        </alternativeName>
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        <name evidence="12" type="primary">EEF1G</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in anchoring the complex to other cellular components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">EF-1 is composed of four subunits: alpha, beta, delta, and gamma.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012778239.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000044205.2">
        <property type="protein sequence ID" value="ENSMICP00000018031.1"/>
        <property type="gene ID" value="ENSMICG00000009834.3"/>
    </dbReference>
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    <dbReference type="KEGG" id="mmur:105878599"/>
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    <dbReference type="GeneTree" id="ENSGT00390000007552"/>
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        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
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        <property type="entry name" value="Elongation factor 1-gamma"/>
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        <property type="entry name" value="Glutaredoxin"/>
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        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
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        <property type="entry name" value="EF1B_G_C_sf"/>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
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        <property type="entry name" value="Glutathione_S-Trfase"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GST C-terminal domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Thioredoxin-like"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="10">
        <location>
            <begin position="2"/>
            <end position="87"/>
        </location>
    </feature>
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            <begin position="88"/>
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    </feature>
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            <begin position="276"/>
            <end position="437"/>
        </location>
    </feature>
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            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
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            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBD5</accession>
    <name>A0A8B7HBD5_MICMU</name>
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        <recommendedName>
            <fullName evidence="5">Anillin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ANLN</name>
    </gene>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with F-actin. Interacts with CD2AP. May interact with RHOA. Interacts with FZR1/CDH1 during mitotic exit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Bleb</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015726">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633023.1">
        <property type="nucleotide sequence ID" value="XM_012777569.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HBD5"/>
    <dbReference type="Ensembl" id="ENSMICT00000051987.2">
        <property type="protein sequence ID" value="ENSMICP00000040051.2"/>
        <property type="gene ID" value="ENSMICG00000008936.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878240"/>
    <dbReference type="CTD" id="54443"/>
    <dbReference type="GeneTree" id="ENSGT00390000008749"/>
    <dbReference type="OrthoDB" id="5915976at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032059">
        <property type="term" value="C:bleb"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000915">
        <property type="term" value="P:actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090521">
        <property type="term" value="P:podocyte cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904172">
        <property type="term" value="P:positive regulation of bleb assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01263">
        <property type="entry name" value="PH_anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000111">
        <property type="entry name" value="anillin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031970">
        <property type="entry name" value="Anillin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051364">
        <property type="entry name" value="Cytokinesis/Rho-signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037840">
        <property type="entry name" value="PH_Anillin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538:SF27">
        <property type="entry name" value="ANILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21538">
        <property type="entry name" value="ANILLIN/RHOTEKIN RTKN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16018">
        <property type="entry name" value="Anillin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="8">
        <location>
            <begin position="980"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="622"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="567"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="467"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00057106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040051.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1121" mass="123733" checksum="7BCBC2FC317330CB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HDN6</accession>
    <name>A0A8B7HDN6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Olfactomedin like 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">OLFML3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OLFML3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002609">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633882.1">
        <property type="nucleotide sequence ID" value="XM_012778428.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HDN6"/>
    <dbReference type="Ensembl" id="ENSMICT00000051015.2">
        <property type="protein sequence ID" value="ENSMICP00000035822.2"/>
        <property type="gene ID" value="ENSMICG00000001412.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105878726"/>
    <dbReference type="KEGG" id="mmur:105878726"/>
    <dbReference type="CTD" id="56944"/>
    <dbReference type="GeneTree" id="ENSGT00940000158083"/>
    <dbReference type="OrthoDB" id="8626508at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003112">
        <property type="entry name" value="Olfac-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050605">
        <property type="entry name" value="Olfactomedin-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192:SF8">
        <property type="entry name" value="OLFACTOMEDIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23192">
        <property type="entry name" value="OLFACTOMEDIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02191">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00284">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51132">
        <property type="entry name" value="OLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Olfactomedin-like" evidence="12">
        <location>
            <begin position="202"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="96"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035822.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="474" mass="53292" checksum="09EE41E79438F425" modified="2022-01-19" version="1">MGPSVFDQSRRKGGGGGCKETVKAFQSSERDPEIRKRRHRPHPASKASHGFEGKRPPAHSYSGPTLQAAMGPSTPLLILFLLSWSGPLQGQQHHLVEYMERRLAALEERLAQCQDQSSRHAAELRDFKNKMLPLLEVAEKEREALRTEADTISGRVDRLEREVDYLETQNPALPCVEFDEVTGGPGTKSKGRRNEKYDMVTDCGYTISQVRSMKILKRFGGPAGLWTKDPLGPTEKIYVLDGTQNDTAFVFPRLRDFTLAMAARKASRVRVPFPWVGTGQLVYGGFLYYARRPPGGPGGGGELENTLQLIKFHLANRTVVDSSVFPAEGLIPPYSLTTDTYIDLAADEEGLWAVYATQEDDRHLCLAKLDPQTLDTEQQWDTPCPRENAEAAFVICGTLYVVYNTRPASRARIQCSFDASGTLTPERAALPYFPRRYGAHASLRYNPRERQLYAWDDGYQIVYKLEMRKKEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HET4</accession>
    <name>A0A8B7HET4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF25</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634410.1">
        <property type="nucleotide sequence ID" value="XM_012778956.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634411.1">
        <property type="nucleotide sequence ID" value="XM_012778957.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HET4"/>
    <dbReference type="Ensembl" id="ENSMICT00000004604.3">
        <property type="protein sequence ID" value="ENSMICP00000004199.1"/>
        <property type="gene ID" value="ENSMICG00000004606.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159981"/>
    <dbReference type="OMA" id="YQKPHLT"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001391">
        <property type="entry name" value="Zinc finger protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001842">
        <property type="entry name" value="Zinc finger protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000128">
        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000338">
        <property type="entry name" value="zinc finger protein 383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="456" mass="53473" checksum="3C372E93DEA32E19" modified="2022-01-19" version="1">MNKFRGPVTLKDVTVEFTKEEWKLLTPAQRTLYKDVMLENYRHLVSVGYRVNKPNGVFKLKQGKEPWVLEVEFPHRSCPEDLRNIHDLGARNQESQAGNSRNGELKKHHKTHTGEKAYECKECGKFFCQKTALIVHQHIHSKNKSYDCDKCGKSFSKNEELTIHQKTHNREKTYECKECKKIFYHLSSLSRHLRTHAGEKPYECNQCGKSFYQKPHLVEHQKTHTGEKPFECTECGKFFYVKAYLMVHQKTHTGEKPYECKECGKAFSQKSHLTVHQRTHTGEKPYKCKECGKFFSRNSHLKTHQRTHTGEKPYECKECRKCFYQKSALTVHQRTHTGEKPFECNKCGKNFFYKSDLTKHQRKHTGEKPYECTECGKSFSVNSVLRLHQRTHTGEKPYKCKECGKSFSQKSHFIIHQRKHTGEKPYECQECGETFIQKSQLTAHQKTHTKKGKADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HKN4</accession>
    <name>A0A8B7HKN4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Collagen type V alpha 1 chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COL5A1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03014969">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014970">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637566.1">
        <property type="nucleotide sequence ID" value="XM_012782112.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065547.1">
        <property type="protein sequence ID" value="ENSMICP00000040562.1"/>
        <property type="gene ID" value="ENSMICG00000000447.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880810"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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        <text evidence="1">Belongs to the Schlafen family. Subgroup III subfamily.</text>
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    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="888" mass="101627" checksum="6FD39BAEBD35BD5A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WKY1</accession>
    <name>A0A8B7WKY1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Semaphorin-3B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SEMA3B</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018227">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135920.1">
        <property type="nucleotide sequence ID" value="XM_020280331.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135921.1">
        <property type="nucleotide sequence ID" value="XM_020280332.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135922.1">
        <property type="nucleotide sequence ID" value="XM_020280333.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135923.1">
        <property type="nucleotide sequence ID" value="XM_020280334.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135924.1">
        <property type="nucleotide sequence ID" value="XM_020280335.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135925.1">
        <property type="nucleotide sequence ID" value="XM_020280336.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135926.1">
        <property type="nucleotide sequence ID" value="XM_020280337.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020135927.1">
        <property type="nucleotide sequence ID" value="XM_020280338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WKY1"/>
    <dbReference type="Ensembl" id="ENSMICT00000016292.3">
        <property type="protein sequence ID" value="ENSMICP00000014849.3"/>
        <property type="gene ID" value="ENSMICG00000016288.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000036835.2">
        <property type="protein sequence ID" value="ENSMICP00000031127.2"/>
        <property type="gene ID" value="ENSMICG00000016288.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105874991"/>
    <dbReference type="CTD" id="7869"/>
    <dbReference type="GeneTree" id="ENSGT00940000157756"/>
    <dbReference type="OrthoDB" id="9988752at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000015">
        <property type="entry name" value="Semaphorin 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000030">
        <property type="entry name" value="Semaphorin 3F like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000008">
        <property type="entry name" value="semaphorin-3B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF37">
        <property type="entry name" value="SEMAPHORIN-3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7" id="KW-0221">Differentiation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044665404" description="Semaphorin-3B" evidence="17">
        <location>
            <begin position="25"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="19">
        <location>
            <begin position="30"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="18">
        <location>
            <begin position="573"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="702"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00074126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031127.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="749" mass="82953" checksum="26A7878217C890C6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WUS7</accession>
    <name>A0A8B7WUS7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tectonic family member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TCTN1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the tectonic-like complex (also named B9 complex).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tectonic family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024867">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138550.1">
        <property type="nucleotide sequence ID" value="XM_020282961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WUS7"/>
    <dbReference type="Ensembl" id="ENSMICT00000026446.2">
        <property type="protein sequence ID" value="ENSMICP00000020987.1"/>
        <property type="gene ID" value="ENSMICG00000004952.3"/>
    </dbReference>
    <dbReference type="CTD" id="79600"/>
    <dbReference type="GeneTree" id="ENSGT00570000079101"/>
    <dbReference type="OrthoDB" id="2104337at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036038">
        <property type="term" value="C:MKS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021956">
        <property type="term" value="P:central nervous system interneuron axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021904">
        <property type="term" value="P:dorsal/ventral neural tube patterning"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001841">
        <property type="term" value="P:neural tube formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904491">
        <property type="term" value="P:protein localization to ciliary transition zone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008589">
        <property type="term" value="P:regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021523">
        <property type="term" value="P:somatic motor neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021537">
        <property type="term" value="P:telencephalon development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040354">
        <property type="entry name" value="TCTN1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011677">
        <property type="entry name" value="TCTN1-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057724">
        <property type="entry name" value="TCTN1-3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611">
        <property type="entry name" value="TECTONIC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14611:SF1">
        <property type="entry name" value="TECTONIC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25752">
        <property type="entry name" value="DUF1619_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07773">
        <property type="entry name" value="TCTN_DUF1619"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044135509" evidence="7">
        <location>
            <begin position="23"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3 N-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="8">
        <location>
            <begin position="204"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Tectonic-1-3" evidence="8">
        <location>
            <begin position="378"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="587" mass="63718" checksum="D9000982368224E9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WXK8</accession>
    <name>A0A8B7WXK8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TNFAIP3 interacting protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TNIP3</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601316.1">
        <property type="nucleotide sequence ID" value="XM_012745862.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601317.1">
        <property type="nucleotide sequence ID" value="XM_012745863.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139535.1">
        <property type="nucleotide sequence ID" value="XM_020283946.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139536.1">
        <property type="nucleotide sequence ID" value="XM_020283947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WXK8"/>
    <dbReference type="Ensembl" id="ENSMICT00000041652.2">
        <property type="protein sequence ID" value="ENSMICP00000029392.1"/>
        <property type="gene ID" value="ENSMICG00000038352.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105860834"/>
    <dbReference type="CTD" id="79931"/>
    <dbReference type="GeneTree" id="ENSGT00510000046908"/>
    <dbReference type="OrthoDB" id="5969558at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071222">
        <property type="term" value="P:cellular response to lipopolysaccharide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002756">
        <property type="term" value="P:MyD88-independent toll-like receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034142">
        <property type="term" value="P:toll-like receptor 4 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.990:FF:000004">
        <property type="entry name" value="TNFAIP3 interacting protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.990">
        <property type="entry name" value="Nemo cc2-lz domain - 1d5 darpin complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032419">
        <property type="entry name" value="CC2-LZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882:SF2">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31882">
        <property type="entry name" value="TNFAIP3-INTERACTING PROTEIN COILED COIL FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16516">
        <property type="entry name" value="CC2-LZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B essential modulator NEMO CC2-LZ" evidence="3">
        <location>
            <begin position="205"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="382" mass="43988" checksum="723BA9B7233BB090" modified="2022-01-19" version="1">MSQHNNERNAKCHPSIARCESMELDNQIRDLIERNASDAKGVTTEVVPCPRNSCSPKTPGKTASVAYLVQDTSRMSAAESSVEHPECAQSSRTNLTHCLEQKIRCLEKQRKELLEVNQQWDQQFRSMKKLYERKVAELQTQLDAAEGLLSAPDGERRPQRPRDGDGPRGPTRNPPREEKEKESLNEELHELKKENKLLKEKNALANKKKEHLECEIRRLNKALQDALNIECSSPPEDCLWKSGECCHEELRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINQTSQSQLNRLNSQIKACQMEKEKLKKQLKQMYFPPCNCGLVFHLRDPWGPTGPGAVQNPQEHPPDCPWNALDQLPPDVQHKANGFSSERKGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7XA21</accession>
    <name>A0A8B7XA21_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">KH RNA binding domain containing, signal transduction associated 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KHDRBS3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KHDRBS family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013466">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144617.1">
        <property type="nucleotide sequence ID" value="XM_020289028.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7XA21"/>
    <dbReference type="Ensembl" id="ENSMICT00000041590.2">
        <property type="protein sequence ID" value="ENSMICP00000034617.1"/>
        <property type="gene ID" value="ENSMICG00000027467.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105882785"/>
    <dbReference type="CTD" id="10656"/>
    <dbReference type="GeneTree" id="ENSGT00940000157280"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22470">
        <property type="entry name" value="KH-I_KHDRBS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000030">
        <property type="entry name" value="KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoformX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032571">
        <property type="entry name" value="Qua1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032335">
        <property type="entry name" value="Sam68-YY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF29">
        <property type="entry name" value="KH DOMAIN-CONTAINING, RNA-BINDING, SIGNAL TRANSDUCTION-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16274">
        <property type="entry name" value="Qua1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16568">
        <property type="entry name" value="Sam68-YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0729">SH3-binding</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="316"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="346" mass="38833" checksum="D3A63BFBC7B564D0" modified="2022-01-19" version="1">MEEKYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGESKDEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPTPTITRGRGGVTARPVGVGVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSEETYDSYGQEEWTNSRHKAPSARSAKGVYRDQPYGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UI49</accession>
    <name>A0A8C5UI49_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ashwin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">C2orf49</name>
        <name evidence="6" type="synonym">C4H2orf49</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ashwin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005412">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005413">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UI49"/>
    <dbReference type="Ensembl" id="ENSMICT00000000227.3">
        <property type="protein sequence ID" value="ENSMICP00000000205.3"/>
        <property type="gene ID" value="ENSMICG00000000227.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007488"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072669">
        <property type="term" value="C:tRNA-splicing ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048598">
        <property type="term" value="P:embryonic morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024887">
        <property type="entry name" value="Ashwin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28359">
        <property type="entry name" value="ASHWIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28359:SF1">
        <property type="entry name" value="ASHWIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15323">
        <property type="entry name" value="Ashwin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000205.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="223" mass="24646" checksum="9DD95FFE80EB760A" modified="2022-01-19" version="1">MAGDVGGRSCTDSELLLHPELLSQEFLLLTLEQKNIAVENDVRINKDNLTDLYVQHAIPLPQRDLWSFSRVPLFDFRSSTVDGLRKRPLIVFDGSSTSTSIKVKKTENGDNDRLKPPPQASFTSNAFRKLSNSSSSVSPLILSSNLPMNNKTEHNNNDTKQNHDLTHRKSPLGSVKSPPLSPVGTTPVKLKRVAPKEEAEAMVSMGVLSMLVVVWMKPEQSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJE6</accession>
    <name>A0A8C5UJE6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Ag(+)(out) = Ag(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75207"/>
            <dbReference type="ChEBI" id="CHEBI:49468"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>Cu(+)(out) = Cu(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:75211"/>
            <dbReference type="ChEBI" id="CHEBI:49552"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Basolateral cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="22">Membrane</location>
            <topology evidence="22">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 22">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006844">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000001102.3">
        <property type="protein sequence ID" value="ENSMICP00000001003.3"/>
        <property type="gene ID" value="ENSMICG00000001104.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155147"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF22">
        <property type="entry name" value="HIGH AFFINITY COPPER UPTAKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14 22" id="KW-0186">Copper</keyword>
    <keyword evidence="12 22" id="KW-0187">Copper transport</keyword>
    <keyword evidence="18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
    <keyword evidence="15 22" id="KW-0406">Ion transport</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0558">Oxidation</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 22" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00036192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001003.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="178" mass="19747" checksum="4F54C0D9553184A9" modified="2022-01-19" version="1">LGHAPVAGLNLRRIFSSHSHGGGDSNMMMMMPMTFYFGFKNVELLFSGLAINTAGEMAGTFVAVFLLVMFYEGLKIARESLLRKSQVSIWYNSMPVPGPNGTILMETHKTVGQQMLSFPHLLQTVLHIIQVVISYFLMLIFMIYNGYLCIAVAAGAGTGYFLFSWKKAVVVDITDHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM09</accession>
    <name>A0A8C5UM09_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cleavage furrow</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010963">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UM09"/>
    <dbReference type="Ensembl" id="ENSMICT00000001242.3">
        <property type="protein sequence ID" value="ENSMICP00000001132.3"/>
        <property type="gene ID" value="ENSMICG00000026486.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163656"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032154">
        <property type="term" value="C:cleavage furrow"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000095">
        <property type="entry name" value="Rho-related GTP-binding protein RhoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001132.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="194" mass="22049" checksum="2635186E52606CA4" modified="2022-01-19" version="1">MVAIRKKLVIVGDGACGKTCLLIVFSKDQFPAVYMLTMFENYVADIQVDGKQVELVLWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENILEKWIPEVKHFCPNVPIILVGNKKDLRNDEHTRQELAKIKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRRKKKSGCLCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UM96</accession>
    <name>A0A8C5UM96_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Centrosomal protein of 78 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">CEP78</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis. Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. Involved in cilium biogenesis and controls cilium length. Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins. Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110. Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PLK4. Interacts with FAM161A. Interacts with IFT20; regulating IFT20 stability and localization. Interacts with TTC21A; regulating TTC21A stability and localization. Interacts with USP16; promoting USP16-dependent deubiquitination of tektins. Interacts with DCAF1/VPRBP; promoting localization of the EDVP complex to centrosomes. Interacts with CEP350; promoting CEP78 localization to centrosome and centriole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CEP78 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014276">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014277">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014278">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UM96"/>
    <dbReference type="Ensembl" id="ENSMICT00000003005.3">
        <property type="protein sequence ID" value="ENSMICP00000002735.3"/>
        <property type="gene ID" value="ENSMICG00000003003.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013287"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044782">
        <property type="term" value="P:cilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000057">
        <property type="entry name" value="Centrosomal protein of 78 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000070">
        <property type="entry name" value="Centrosomal protein of 78 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026212">
        <property type="entry name" value="Cep78"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24110:SF3">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 78 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02062">
        <property type="entry name" value="CENTROSOME78"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="630"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="453"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00069623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002735.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="712" mass="78842" checksum="C365EF6E7C6EAD66" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UP47</accession>
    <name>A0A8C5UP47_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Src kinase-associated phosphoprotein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Src family-associated phosphoprotein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SKAP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628805.1">
        <property type="nucleotide sequence ID" value="XM_012773351.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012628806.1">
        <property type="nucleotide sequence ID" value="XM_012773352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UP47"/>
    <dbReference type="Ensembl" id="ENSMICT00000000466.3">
        <property type="protein sequence ID" value="ENSMICP00000000425.2"/>
        <property type="gene ID" value="ENSMICG00000000466.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875915"/>
    <dbReference type="KEGG" id="mmur:105875915"/>
    <dbReference type="CTD" id="8935"/>
    <dbReference type="GeneTree" id="ENSGT00390000017856"/>
    <dbReference type="OrthoDB" id="243840at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000194">
        <property type="entry name" value="Putative src kinase-associated phosphoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000097">
        <property type="entry name" value="Putative src kinase-associated phosphoprotein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037781">
        <property type="entry name" value="SKAP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129:SF2">
        <property type="entry name" value="SRC KINASE-ASSOCIATED PHOSPHOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15129">
        <property type="entry name" value="SRC-ASSOCIATED ADAPTOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0075">B-cell activation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="116"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="297"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000425.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="41265" checksum="1D6B53E14DF21115" modified="2022-01-19" version="1">MLNPSSTSSPYPLPEEIRNLLADFETFVADILRGENLSKKAKEKRESLVKKIKDVKSIYLPEFQDKGDVEDGEEYDDPFAGASDTVSLASERYDKDDEAPSDGTQFPPIPAQDLPFVLKAGYLEKRRKDHSFLGFEWQKRWCALSKGVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKDAKKDCCFEISAPDKRVYQFTAASSKDAEEWVQQLKFVLQDMESDVIPEDDDERGDLYDDVDHPLSMSSPSISSQPIDDEIYEELPEEEEDGALVKMEEQRKMNQDSVHHTLGDKNTDYANFYQGLWDCTGHLSDELSFKRGDVIYILSKEYNRYGWWVGEMKGAIGLVPKAYIMEMYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UT36</accession>
    <name>A0A8C5UT36_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Katanin p80 subunit C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015076">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UT36"/>
    <dbReference type="Ensembl" id="ENSMICT00000003856.3">
        <property type="protein sequence ID" value="ENSMICP00000003517.3"/>
        <property type="gene ID" value="ENSMICG00000044577.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012351"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028021">
        <property type="entry name" value="Katanin_C-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042404">
        <property type="entry name" value="KATNBL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14682">
        <property type="entry name" value="KATNB1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14682:SF1">
        <property type="entry name" value="KATNB1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13925">
        <property type="entry name" value="Katanin_con80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Katanin p80 subunit C-terminal" evidence="5">
        <location>
            <begin position="135"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003517.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="248" mass="28401" checksum="FB1C5E224468F072" modified="2022-01-19" version="1">MASETHNVNKQNFCDDIEDHSTDFPRKRISNFTNKNIKRTVGQAVKSPDKLHKVIYHRKKVHDPFPNPCYRKKQSPRSGSRDMANKENELACAGHLPEKLRHDSGTYLINSSDSKSPSSKYIGEFEIECSFNLNFTFWRKLSISELVAYLVRIEDLGVVVDCLPVLTNSLQEEKQYISLGCCVDLLPLVKSLLKSKFEEYVIVGFNWLQAILKQQLSGLWEQENHLTLVPGYTGNIAKDIDAYLLQLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UTL3</accession>
    <name>A0A8C5UTL3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Purinergic receptor P2Y11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">P2RY11</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UTL3"/>
    <dbReference type="Ensembl" id="ENSMICT00000006920.3">
        <property type="protein sequence ID" value="ENSMICP00000006305.3"/>
        <property type="gene ID" value="ENSMICG00000006915.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01030000234518"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045031">
        <property type="term" value="F:G protein-coupled ATP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030594">
        <property type="term" value="F:neurotransmitter receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071318">
        <property type="term" value="P:cellular response to ATP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023041">
        <property type="term" value="P:neuronal signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000283">
        <property type="entry name" value="Purinergic receptor P2Y11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231:SF46">
        <property type="entry name" value="P2Y PURINOCEPTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24231">
        <property type="entry name" value="PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01157">
        <property type="entry name" value="P2YPURNOCPTR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 9" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
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    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="12">
        <location>
            <begin position="45"/>
            <end position="322"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="362"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
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        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006305.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="376" mass="40510" checksum="04B4E676D7A4F448" modified="2022-01-19" version="1">MAATILGAKPCPANFSAAADRILSRFQEDFLWPVLVAEFLVAVVANGLALYRFSAREQRPWHPAVVFSAQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAACRLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFTRSHLRPKHAWALSAAGWVLAALLAAPTLSFSHLKRPQQEAARCSVASPEACTKCLGTAGDLQLEAYRAYSLALAGLGCGLPLLLSLAAYGALGCAVLHSPSMTTAEKLRVVALVASGVLLYASSYVPYHVTQVLNTDARRRWRARCPGFADVAQAKAALELGPYLGYQAMRGVMPLAFCIHPLLYMAVAPSLGCCRQCCRGCGRGRNPEDAKSTGQALPLDVIATSKNSSEPQSPELSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UV39</accession>
    <name>A0A8C5UV39_MICMU</name>
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        <submittedName>
            <fullName evidence="4">Metallophosphoesterase domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MPPED1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0046 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008968">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008971">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UV39"/>
    <dbReference type="Ensembl" id="ENSMICT00000005472.3">
        <property type="protein sequence ID" value="ENSMICP00000004986.2"/>
        <property type="gene ID" value="ENSMICG00000005477.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000007681"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Calcineurin-like_Pesterase"/>
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        <property type="entry name" value="Calcineurin-like_PHP"/>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
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        <property type="entry name" value="UPF0046_metallophosphoest"/>
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        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="Metallo-dependent phosphatases"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
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        <location>
            <begin position="29"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="91"/>
            <end position="254"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00007993"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004986.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="288" mass="32531" checksum="C78F3695B13BB4B1" modified="2022-01-19" version="1">MWRSRWDAGVLKAEALALLPCGLGMAFSQSHVMAGRRHQHGRLIVEVDEYSSNPTQAFTFYNINQGRFQPPHVQMVDPVPHDAPKPPGYTRFVCVSDTHSRTDPIQMPYGDVLIHAGDFTELGLPSEVKKFNEWLGSLPYEYKIVIAGNHELTFDQEFMADLIKQDFYYFPSVSKLKPESYENVQSLLTNCIYLQDSEVTVRGFRVYGSPWQPWFYGWGFNLPRGQALLEKWSLIPEGVDVLITHGPPLGYGVMADGTTTYVNASVCTVNYQPVNPPIVIDLPTPRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVT8</accession>
    <name>A0A8C5UVT8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Taperin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TPRN</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVT8"/>
    <dbReference type="Ensembl" id="ENSMICT00000006077.3">
        <property type="protein sequence ID" value="ENSMICP00000005540.3"/>
        <property type="gene ID" value="ENSMICG00000006079.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000064035"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005902">
        <property type="term" value="C:microvillus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120044">
        <property type="term" value="C:stereocilium base"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060088">
        <property type="term" value="P:auditory receptor cell stereocilium organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120045">
        <property type="term" value="P:stereocilium maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025903">
        <property type="entry name" value="Phostensin/Taperin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025907">
        <property type="entry name" value="Phostensin/Taperin_PP1-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026671">
        <property type="entry name" value="PPP1R18/Tprn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21685:SF1">
        <property type="entry name" value="TAPERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21685">
        <property type="entry name" value="TON-B BOX DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13914">
        <property type="entry name" value="Phostensin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13916">
        <property type="entry name" value="Phostensin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phostensin/Taperin N-terminal" evidence="7">
        <location>
            <begin position="9"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Phostensin/Taperin PP1-binding" evidence="6">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Ongeri F."/>
                <person name="Osuji N."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Shamim M."/>
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                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
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                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
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                <person name="Kurapati P."/>
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                <person name="Lee S."/>
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                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
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                <person name="Nguyen L."/>
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                <person name="Quiroz J."/>
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                <person name="Weissenberger G."/>
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                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="18">Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system. Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize. Highly selective for sodium, they are permeable to other cations. By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
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    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Li(+)(in) = Li(+)(out)</text>
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            <dbReference type="ChEBI" id="CHEBI:49713"/>
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    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Can form homotrimers. Heterotrimer; forms functional heterotrimers producing channel with different properties. Forms heterotrimers with ASIC1; while ASIC1 determines current amplitude, ASIC2 influences the properties of the current. Forms heterotrimers with ASIC3; resulting in channels with distinct properties. Interacts with STOM; STOM regulates the gating of ASIC2-containing channels. Interacts with PICK1; promotes ASIC3 phosphorylation by PKC and activation of ASIC2/ASIC3 heterotrimers.</text>
    </comment>
    <comment type="subcellular location">
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            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="19">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC2 subfamily.</text>
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        <property type="term" value="C:neuronal cell body"/>
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    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
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        <property type="term" value="P:phototransduction"/>
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        <property type="entry name" value="acid-sensing ion channel 1 isoform X2"/>
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        <property type="entry name" value="Acid-sensing ion channel subunit 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="acid-sensing ion channel 1 domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Acid-sensing ion channel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ENaC"/>
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        <property type="entry name" value="ENaC_chordates"/>
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    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
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        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF128">
        <property type="entry name" value="ACID-SENSING ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="3" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="13" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00044635"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00078576"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010842.2"/>
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    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="512" mass="57666" checksum="0DD55CB8673905E0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2G2</accession>
    <name>A0A8C5V2G2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 18">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ALAD</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 18">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homooctamer; active form. Homohexamer; low activity form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 18"/>
    <dbReference type="EMBL" id="ABDC03014830">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2G2"/>
    <dbReference type="Ensembl" id="ENSMICT00000015100.3">
        <property type="protein sequence ID" value="ENSMICP00000013771.3"/>
        <property type="gene ID" value="ENSMICG00000015095.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006998"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071353">
        <property type="term" value="P:cellular response to interleukin-4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006785">
        <property type="term" value="P:heme B biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901799">
        <property type="term" value="P:negative regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 18" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="15">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="15">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013771.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="324" mass="35215" checksum="93802F99E3494954" modified="2022-01-19" version="1">MQPQSVLHSGYFHPLLRTWQTAAATLDASNLIYPIFVTDVPDDVQPIASLPGVARYGVNRLEEMLSPLVEEGLCCVLVFGVDERGSAADSEESPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGAFLAKESCQRLAEVAVAYAKAGCQVVAPSDMMDGRVGAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKAKHPELPLAVYHVSGEFAMLWHGARAGAFDLKAAVLEAMTAFRRAGADIVITYYTPQLLQWLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2J7</accession>
    <name>A0A8C5V2J7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">G-protein coupled receptor 161</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19 21" type="primary">GPR161</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="21">Liver</tissue>
        </source>
    </reference>
    <reference evidence="19" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003330">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639337.1">
        <property type="nucleotide sequence ID" value="XM_012783883.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2J7"/>
    <dbReference type="Ensembl" id="ENSMICT00000011713.3">
        <property type="protein sequence ID" value="ENSMICP00000010662.3"/>
        <property type="gene ID" value="ENSMICG00000011715.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881902"/>
    <dbReference type="CTD" id="23432"/>
    <dbReference type="GeneTree" id="ENSGT00940000157829"/>
    <dbReference type="OrthoDB" id="5980076at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060170">
        <property type="term" value="C:ciliary membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15214">
        <property type="entry name" value="7tmA_GPR161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000091">
        <property type="entry name" value="G-protein coupled receptor 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22752:SF10">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 16" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 21" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="18">
        <location>
            <begin position="61"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00070749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010662.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="RefSeq" id="XP_012639337.1"/>
        </source>
    </evidence>
    <sequence length="546" mass="60217" checksum="39DE613D164F8613" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V303</accession>
    <name>A0A8C5V303_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cadherin-15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cadherin-14</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Muscle cadherin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CDH15</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
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    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="13">Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.</text>
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            <topology evidence="1 18">Single-pass type I membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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            <taxon>Mammalia</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
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                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <consortium name="Ensembl"/>
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    <comment type="subcellular location">
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        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN 1"/>
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        <property type="entry name" value="GLUTAMATE RECEPTOR-INTERACTING PROTEIN GRIP"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V517</accession>
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            <taxon>Mammalia</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="1">Important role in determination of the surface properties of the casein micelles.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the beta-casein family.</text>
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    </dbReference>
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        <property type="entry name" value="Casein"/>
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        <property type="entry name" value="Casein_beta"/>
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        <property type="entry name" value="Casein_CS"/>
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        <property type="entry name" value="BETA CASEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="BETA-CASEIN"/>
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        <property type="entry name" value="CASEIN_ALPHA_BETA"/>
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            <begin position="1"/>
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        </location>
    </feature>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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            <dbReference type="ARBA" id="ARBA00022553"/>
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            <dbReference type="ARBA" id="ARBA00022743"/>
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        <source>
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    </evidence>
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            <dbReference type="Ensembl" id="ENSMICP00000013842.3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="223" mass="25029" checksum="D45C1E98AE3E4264" modified="2022-01-19" version="1">MKVLILACLVALALAKETVESLSSSEESVTHDKQKIEKVKHLEQKQRENERQEKLNPFIQQQQPLVYPFAEPIPYTILPQNILPPLAQPAVVPTFLQPEVMQVSKSKQTAFPKHKVMPFLKSPVMPSFDPQNPNLKNQALALSLLQPLMPQVPQPIPQTSVLPPQSLWAPLQPKALPIPQQVVPYPQRAMPLQALLLYQNPTARQFYPATQQPLAPAHNPVIV</sequence>
</entry>
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    <name>A0A8C5V6M9_MICMU</name>
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        <submittedName>
            <fullName evidence="14">Solute carrier family 25 member 35</fullName>
        </submittedName>
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        <name evidence="14" type="primary">SLC25A35</name>
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    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Putative antiporter that exchanges dicarboxylates and sulfur oxoanions across the inner membrane of mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)</text>
            <dbReference type="Rhea" id="RHEA:76595"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:28965"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020542">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630901.1">
        <property type="nucleotide sequence ID" value="XM_012775447.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630910.1">
        <property type="nucleotide sequence ID" value="XM_012775456.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V6M9"/>
    <dbReference type="Ensembl" id="ENSMICT00000048932.2">
        <property type="protein sequence ID" value="ENSMICP00000016718.1"/>
        <property type="gene ID" value="ENSMICG00000013857.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877147"/>
    <dbReference type="KEGG" id="mmur:105877147"/>
    <dbReference type="CTD" id="399512"/>
    <dbReference type="GeneTree" id="ENSGT00940000160771"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000039">
        <property type="entry name" value="Solute carrier family 25 member 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF2">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="100"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="203"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00035937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="300" mass="32499" checksum="403D3A1CAE9DDB1D" modified="2022-01-19" version="1">MDFLMSGLAACGACVFTNPLEVVKTRMQLQGELQAPGTYQKHYRNVFHAFITIGRVDGLAALQKGLAPALLYQFLMNGIRLGTYGLAEAGGYMHTADGNFSHTRSAAVGGLAGILGAYLGSPIYMVKTHIQAQAASEIAVGHQYKHQGMLQALNEIGRKHGVVGLFRGAVGGLPRVIVGSSAQLCTFSSTKDLLSQWEIFPPQSWKVALAASMVSGIAVVLAMTPFDVASTRLYNQPTDAQGKGLMYRGILDALLQIARTEGIFGMYKGIGASYFRLGPHTVLSLFFWDQLRFLYYTYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7P1</accession>
    <name>A0A8C5V7P1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ATG7</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027290">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027291">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V7P1"/>
    <dbReference type="Ensembl" id="ENSMICT00000016549.3">
        <property type="protein sequence ID" value="ENSMICP00000015085.2"/>
        <property type="gene ID" value="ENSMICG00000016547.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017509"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071455">
        <property type="term" value="P:cellular response to hyperoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.100:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000156">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="5 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="13">
        <location>
            <begin position="53"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="12">
        <location>
            <begin position="378"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015085.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="743" mass="82947" checksum="9551031AFB9B57D4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VFT1</accession>
    <name>A0A8C5VFT1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="19">Dynein axonemal heavy chain 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">DNAH12</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018338">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018339">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018340">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018341">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018342">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018343">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018345">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018346">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000038924.2">
        <property type="protein sequence ID" value="ENSMICP00000022207.2"/>
        <property type="gene ID" value="ENSMICG00000005596.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154280"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036156">
        <property type="term" value="C:inner dynein arm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003341">
        <property type="term" value="P:cilium movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000002">
        <property type="entry name" value="Dynein axonemal heavy chain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000004">
        <property type="entry name" value="Dynein axonemal heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002141">
        <property type="entry name" value="Dynein heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000003">
        <property type="entry name" value="Dynein heavy chain 12, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000002">
        <property type="entry name" value="Dynein heavy chain 2, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000223">
        <property type="entry name" value="Dynein heavy chain 3, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000044">
        <property type="entry name" value="Dynein heavy chain 5, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000001">
        <property type="entry name" value="dynein heavy chain 7, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000005">
        <property type="entry name" value="Dynein, axonemal, heavy chain 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000362">
        <property type="entry name" value="Dynein, axonemal, heavy chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041589">
        <property type="entry name" value="DNAH3_AAA_lid_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878:SF70">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 2, AXONEMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22878">
        <property type="entry name" value="DYNEIN HEAVY CHAIN 6, AXONEMAL-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17857">
        <property type="entry name" value="AAA_lid_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1225"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1761"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="2549"/>
            <end position="2614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022207.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="3737" mass="429348" checksum="1726A0011E3E3AA7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMG2</accession>
    <name>A0A8C5VMG2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">NFIX</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Binds DNA as a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CTF/NF-I family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027782">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645880.1">
        <property type="nucleotide sequence ID" value="XM_012790426.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMG2"/>
    <dbReference type="Ensembl" id="ENSMICT00000030588.2">
        <property type="protein sequence ID" value="ENSMICP00000023513.2"/>
        <property type="gene ID" value="ENSMICG00000000785.3"/>
    </dbReference>
    <dbReference type="CTD" id="4784"/>
    <dbReference type="GeneTree" id="ENSGT00950000182916"/>
    <dbReference type="OrthoDB" id="10055441at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000647">
        <property type="entry name" value="CTF/NFI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020604">
        <property type="entry name" value="CTF/NFI_DNA-bd-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019739">
        <property type="entry name" value="CTF/NFI_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019548">
        <property type="entry name" value="CTF/NFI_DNA-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003619">
        <property type="entry name" value="MAD_homology1_Dwarfin-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492:SF3">
        <property type="entry name" value="NUCLEAR FACTOR 1 X-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11492">
        <property type="entry name" value="NUCLEAR FACTOR I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00859">
        <property type="entry name" value="CTF_NFI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03165">
        <property type="entry name" value="MH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10524">
        <property type="entry name" value="NfI_DNAbd_pre-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00523">
        <property type="entry name" value="DWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00349">
        <property type="entry name" value="CTF_NFI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51080">
        <property type="entry name" value="CTF_NFI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CTF/NF-I" evidence="11">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="403"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023513.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="494" mass="54156" checksum="8924299B719CE291" modified="2022-01-19" version="1">MDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSTTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKSTSTAPDGAALTPPSPSFATTGTASANRFVSIGPRDGNFLNIPQQSQSWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNY8</accession>
    <name>A0A8C5VNY8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VNY8"/>
    <dbReference type="Ensembl" id="ENSMICT00000027735.2">
        <property type="protein sequence ID" value="ENSMICP00000024363.2"/>
        <property type="gene ID" value="ENSMICG00000029180.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00500000045816"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024363.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="585" mass="62241" checksum="3009CF7DDF649B23" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQ42</accession>
    <name>A0A8C5VQ42_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rho GTPase activating protein 28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ARHGAP28</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023054">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601638.1">
        <property type="nucleotide sequence ID" value="XM_012746184.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQ42"/>
    <dbReference type="Ensembl" id="ENSMICT00000029232.2">
        <property type="protein sequence ID" value="ENSMICP00000027717.2"/>
        <property type="gene ID" value="ENSMICG00000009879.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860987"/>
    <dbReference type="CTD" id="79822"/>
    <dbReference type="GeneTree" id="ENSGT00940000158929"/>
    <dbReference type="OrthoDB" id="27680at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051497">
        <property type="term" value="P:negative regulation of stress fiber assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04391">
        <property type="entry name" value="RhoGAP_ARHGAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000018">
        <property type="entry name" value="Rho GTPase activating protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057323">
        <property type="entry name" value="RHG40/28/18_ubiquitin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14963:SF5">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25442">
        <property type="entry name" value="Ubiquitin_RHG40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="371"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00055252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027717.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="720" mass="80677" checksum="3D2C15D268F25D0F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VQU9</accession>
    <name>A0A8C5VQU9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Glutamate metabotropic receptor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">GRM6</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023105">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645450.1">
        <property type="nucleotide sequence ID" value="XM_012789996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VQU9"/>
    <dbReference type="Ensembl" id="ENSMICT00000039234.2">
        <property type="protein sequence ID" value="ENSMICP00000025284.1"/>
        <property type="gene ID" value="ENSMICG00000000566.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885212"/>
    <dbReference type="CTD" id="2916"/>
    <dbReference type="GeneTree" id="ENSGT01030000234648"/>
    <dbReference type="OrthoDB" id="425344at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035841">
        <property type="term" value="C:new growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008066">
        <property type="term" value="F:glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050908">
        <property type="term" value="P:detection of light stimulus involved in visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007216">
        <property type="term" value="P:G protein-coupled glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905665">
        <property type="term" value="P:positive regulation of calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007416">
        <property type="term" value="P:synapse assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15453">
        <property type="entry name" value="7tmC_mGluR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06376">
        <property type="entry name" value="PBP1_mGluR_groupIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000009">
        <property type="entry name" value="Glutamate receptor, metabotropic 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.50.30:FF:000001">
        <property type="entry name" value="metabotropic glutamate receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.30">
        <property type="entry name" value="GPCR, family 3, nine cysteines domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000337">
        <property type="entry name" value="GPCR_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011500">
        <property type="entry name" value="GPCR_3_9-Cys_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038550">
        <property type="entry name" value="GPCR_3_9-Cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000112">
        <property type="entry name" value="GPCR_3__mGluR6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017978">
        <property type="entry name" value="GPCR_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017979">
        <property type="entry name" value="GPCR_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000162">
        <property type="entry name" value="GPCR_3_mtglu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050726">
        <property type="entry name" value="mGluR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24060">
        <property type="entry name" value="METABOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00003">
        <property type="entry name" value="7tm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
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        <property type="entry name" value="NCD3G"/>
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        <property type="entry name" value="GPCRMGR"/>
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        <property type="entry name" value="MTABOTROPC6R"/>
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    <dbReference type="PRINTS" id="PR00593">
        <property type="entry name" value="MTABOTROPICR"/>
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    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00979">
        <property type="entry name" value="G_PROTEIN_RECEP_F3_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F3_4"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 14" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <feature type="chain" id="PRO_5044150126" evidence="15">
        <location>
            <begin position="28"/>
            <end position="875"/>
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        <location>
            <begin position="588"/>
            <end position="609"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="621"/>
            <end position="641"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="653"/>
            <end position="674"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="747"/>
            <end position="768"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="780"/>
            <end position="805"/>
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    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="811"/>
            <end position="835"/>
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        <location>
            <begin position="583"/>
            <end position="857"/>
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    </feature>
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        <location>
            <begin position="853"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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        <source>
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        <source>
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            <dbReference type="PROSITE" id="PS50259"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="875" mass="95198" checksum="4BB2AB985FDAD4B6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VSI4</accession>
    <name>A0A8C5VSI4_MICMU</name>
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        <submittedName>
            <fullName evidence="13">Rho guanine nucleotide exchange factor 7</fullName>
        </submittedName>
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    <gene>
        <name evidence="13" type="primary">ARHGEF7</name>
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    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Lamellipodium</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:storage vacuole"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein kinase binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Rho guanine nucleotide exchange factor 6"/>
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        <property type="entry name" value="Rho guanine nucleotide exchange factor 7"/>
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        <property type="entry name" value="Rho guanine nucleotide exchange factor 7 isoform X1"/>
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        <property type="entry name" value="rho guanine nucleotide exchange factor 7 isoform X1"/>
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        <property type="entry name" value="L1 transposable element, trimerization domain"/>
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        <property type="entry name" value="PH_DOMAIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="163"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="DH" evidence="11">
        <location>
            <begin position="250"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="452"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="396"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="810"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026268.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="862" mass="97019" checksum="6B38CE0F887CE339" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VT37</accession>
    <name>A0A8C5VT37_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015111">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VT37"/>
    <dbReference type="Ensembl" id="ENSMICT00000037602.2">
        <property type="protein sequence ID" value="ENSMICP00000028481.1"/>
        <property type="gene ID" value="ENSMICG00000027282.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154844"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01852">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000366">
        <property type="entry name" value="GTPase, IMAP family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006703">
        <property type="entry name" value="G_AIG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045058">
        <property type="entry name" value="GIMA/IAN/Toc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903:SF69">
        <property type="entry name" value="GTPASE IMAP FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10903">
        <property type="entry name" value="GTPASE, IMAP FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04548">
        <property type="entry name" value="AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51720">
        <property type="entry name" value="G_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="AIG1-type G" evidence="5">
        <location>
            <begin position="22"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="307" mass="34092" checksum="2538B3353337E6A9" modified="2022-01-19" version="1">MEGPQKSRYGTMAEEDNQFATSPSLRIILVGKTGCGKSATGNSILRQPVFESKLAAQPVTRACQAEMGTWHGRNILVVDTPSIFEAQAQDTCKDIGDCYLLSAPGPHVLLLVTQLGRFTAQDTAAVRRVKEVFGAGAMRHAVILFTHKEDLGGEPLSDYVAGTDNRSLQGLVRECGRRYCGFNNRAGGQEQEWQLAELMALVERLQRECEGSFYTNGLFLEAQMLRRRRDGACHEDHGAYGQYLAKVKQQVEKHKRELREEERNWVCKALLRVEHWVASNIVTSAFIAICVLIFLAIVIALSIAHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VW57</accession>
    <name>A0A8C5VW57_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-box/LRR-repeat protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">F-box and leucine-rich repeat protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-box protein FBL12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">FBXL12</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with SKP1 and CUL1.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027845">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027846">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646146.1">
        <property type="nucleotide sequence ID" value="XM_012790692.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VW57"/>
    <dbReference type="Ensembl" id="ENSMICT00000030926.2">
        <property type="protein sequence ID" value="ENSMICP00000030232.2"/>
        <property type="gene ID" value="ENSMICG00000033575.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885611"/>
    <dbReference type="CTD" id="54850"/>
    <dbReference type="GeneTree" id="ENSGT00390000003354"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22123">
        <property type="entry name" value="F-box_FBXL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000208">
        <property type="entry name" value="F-box/LRR-repeat protein 12 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF153">
        <property type="entry name" value="F-BOX_LRR-REPEAT PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00062674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00083343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030232.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="326" mass="37125" checksum="AC202E4997C685C4" modified="2022-01-19" version="1">MATFAELPDSVLLEIFSYLPVRDRIRISRVCHRWKRLVDDRWLWRHVDLTLYTMRPKVMWHLLRRYMASRLYSLRMGGYLFSGSQAPQLSPALMRALGQKCPNLKRLCLHVADLSMVPITSLPPTLRTLELHSCEISMAWLMKQQDPTVLPLLECIVLDRVPAFRDEHLQGLTRFRALRSLVLGGTYRVTETGLDASLQEMSYLQRLEVLGCTLSADGTLLAISRHLRDVRKIRLTVRGLSAPGLAVLEGMPALESLCLLGPLITPEMPSPTEILSSCLTMPKLRVLELQGLGWEGQEAERILCKGLPHCMVIVRACPKESMDWWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWH8</accession>
    <name>A0A8C5VWH8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA methyltransferase 1-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DMAP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03001560">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631391.1">
        <property type="nucleotide sequence ID" value="XM_012775937.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWH8"/>
    <dbReference type="Ensembl" id="ENSMICT00000053868.2">
        <property type="protein sequence ID" value="ENSMICP00000029234.1"/>
        <property type="gene ID" value="ENSMICG00000013636.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877436"/>
    <dbReference type="KEGG" id="mmur:105877436"/>
    <dbReference type="CTD" id="55929"/>
    <dbReference type="GeneTree" id="ENSGT00390000016466"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061629">
        <property type="term" value="F:RNA polymerase II-specific DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905168">
        <property type="term" value="P:positive regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11658">
        <property type="entry name" value="SANT_DMAP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000087">
        <property type="entry name" value="DNA methyltransferase 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008468">
        <property type="entry name" value="DMAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05499">
        <property type="entry name" value="DMAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="9">
        <location>
            <begin position="124"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="DNA methyltransferase 1-associated 1" evidence="8">
        <location>
            <begin position="243"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="405"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="468" mass="53118" checksum="125E8D7034CFBFA1" modified="2022-01-19" version="1">MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRTQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPAPASAEPAVPEPGLGPDPTKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VXZ1</accession>
    <name>A0A8C5VXZ1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Sushi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">LOC105868175</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">(Microbial infection) Acts as a receptor for Epstein-Barr virus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the receptors of complement activation (RCA) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029925">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VXZ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000028053.2">
        <property type="protein sequence ID" value="ENSMICP00000032516.2"/>
        <property type="gene ID" value="ENSMICG00000034334.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160375"/>
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        <property type="term" value="P:regulation of complement-dependent cytotoxicity"/>
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        <property type="entry name" value="Complement C3d receptor 2"/>
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        <property type="entry name" value="Complement component receptor type 1"/>
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        <property type="entry name" value="Membrane cofactor protein"/>
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        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
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        <property type="entry name" value="COMPLEMENT RECEPTOR TYPE 1"/>
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    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1183">Host cell receptor for virus entry</keyword>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1171" mass="128157" checksum="CA26CEF104C6A22A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W185</accession>
    <name>A0A8C5W185_MICMU</name>
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        <recommendedName>
            <fullName evidence="5">receptor protein serine/threonine kinase</fullName>
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        </recommendedName>
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        <name evidence="26" type="primary">BMPR1A</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03019072">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012788029.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000030344.1"/>
        <property type="gene ID" value="ENSMICG00000003384.3"/>
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        <property type="component" value="Chromosome 15"/>
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        <property type="term" value="C:caveola"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:HFE-transferrin receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:BMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:BMP receptor activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein homodimerization activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="531" mass="60065" checksum="4B4441BD1FA446C4" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W427</accession>
    <name>A0A8C5W427_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide biosynthesis domain containing 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">Protein PBDC1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">PBDC1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="5">Liver</tissue>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03033802">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610807.1">
        <property type="nucleotide sequence ID" value="XM_012755353.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W427"/>
    <dbReference type="Ensembl" id="ENSMICT00000031905.2">
        <property type="protein sequence ID" value="ENSMICP00000036676.1"/>
        <property type="gene ID" value="ENSMICG00000030118.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105866164"/>
    <dbReference type="KEGG" id="mmur:105866164"/>
    <dbReference type="CTD" id="51260"/>
    <dbReference type="GeneTree" id="ENSGT00390000016333"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="2">
        <location>
            <begin position="35"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="RefSeq" id="XP_012610807.1"/>
        </source>
    </evidence>
    <sequence length="220" mass="24804" checksum="BE2FCD1F915F58DA" modified="2022-01-19" version="1">MEATGGTEEPVSGELVSVAHALSLPAESYGNDPDIEMAWAMRAMQHAEVYYKLISSVDPQFLKLTKVDDQIYSEFRENFEKLRIDILDPEELKSESAKEKWRPFCLKFDGIVEDFNYGTLLRLDCSQGYTEENTIFAPRIQFFAIEIARNREGYNKAVYISVQDKKGEKGANSGGEKEADSGEEEKGVNKEEEEKEKTDKGGEKEKEADTEISKSGETAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W621</accession>
    <name>A0A8C5W621_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="21">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">BCAT2</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="21"/>
    <dbReference type="EMBL" id="ABDC03026861">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609706.1">
        <property type="nucleotide sequence ID" value="XM_012754252.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W621"/>
    <dbReference type="Ensembl" id="ENSMICT00000044715.2">
        <property type="protein sequence ID" value="ENSMICP00000037270.1"/>
        <property type="gene ID" value="ENSMICG00000013280.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865591"/>
    <dbReference type="CTD" id="587"/>
    <dbReference type="GeneTree" id="ENSGT00390000009532"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990830">
        <property type="term" value="P:cellular response to leukemia inhibitory factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006550">
        <property type="term" value="P:L-isoleucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010817">
        <property type="term" value="P:regulation of hormone levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000002">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000007">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF39">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 21" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 21" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="13 21" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 20" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="18">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="393" mass="44469" checksum="62AD4C45F9DDCA9E" modified="2022-01-19" version="1">MAAAALAQIWARKLLPVPWLLCAPRRYASSDFKAADLQLEMTKTPHKKPDPREPLVFGKTFTDHMLMVEWNEKKGWSQPRIQPFQNLTLHPACSSLHYSLQLFEGLKAFKGRDQQVRLFRPWLNMDRMLRSALRLCLPSFDKGELLECIRRLIEVDKDWVPDSAGTSLYVRPVLIGNEPSLGVTRPSQALLYVILCPVGSYFRGDSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEAKKKGCEQVLWLYGPDQQLTEVGTMNIFVYWTHKDGVLELVTPPLDGVILPGVVRQSLLDLAQTWGEFRVAERRITMKELLQALEEGRVREVFGSGTACQVCPVHQILYQGQHLHIPTMENGPELILRFQKELKAIQYGTSAHEWMLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XB09</accession>
    <name>A0A8C5XB09_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 46 member 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC46A2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. SLC46A family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014828">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012624370.1">
        <property type="nucleotide sequence ID" value="XM_012768916.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XB09"/>
    <dbReference type="Ensembl" id="ENSMICT00000001132.3">
        <property type="protein sequence ID" value="ENSMICP00000001030.1"/>
        <property type="gene ID" value="ENSMICG00000001133.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873720"/>
    <dbReference type="KEGG" id="mmur:105873720"/>
    <dbReference type="CTD" id="57864"/>
    <dbReference type="GeneTree" id="ENSGT00950000183096"/>
    <dbReference type="OMA" id="AYWSGVM"/>
    <dbReference type="OrthoDB" id="430300at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140360">
        <property type="term" value="F:cyclic-GMP-AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140361">
        <property type="term" value="P:cyclic-GMP-AMP transmembrane import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070233">
        <property type="term" value="P:negative regulation of T cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070430">
        <property type="term" value="P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045580">
        <property type="term" value="P:regulation of T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043029">
        <property type="term" value="P:T cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048538">
        <property type="term" value="P:thymus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF3">
        <property type="entry name" value="THYMIC STROMAL COTRANSPORTER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="475" mass="50983" checksum="172B69034C85C8DA" modified="2022-01-19" version="1">MGPGVTCPWSGRLPRLQVRTWIEPVVASTQVASALYDAGLLLVVKASFGGGGSSNHSTSPSPRGTLEDQQQKAISNFYIVYNLVVGLTPLLSAYGLGWLSDRYHRKISICVSLLGFLLSRLGLLLKVLLDWPVEMLYGAAALNGLCGGFSAFWSGVMALGSLGSSQGRRSVRLILIDLILGLAGFCGSMASGYLFEQMAGHSGQGLILTACSVSCATFALFYSLLVLKVPESVAKPSQELPSVDTVSGTVGTYRSLDPDQLDKQSVVGHLPSPGKAKPPKTVIALLFVGAIIYDLAVVGTVDVVPLFVLREPLRWNQVQVGYGMAAGYTVFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAAMMFALIPITTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTMYNKIYQLTMDTFVGTCFALSSFLSFLAIIPIGIVAYKQVPWSQYGDITEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XDQ2</accession>
    <name>A0A8C5XDQ2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vitamin K-dependent protein S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PROS1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03032792">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032793">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03032794">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140296.1">
        <property type="nucleotide sequence ID" value="XM_020284707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XDQ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000011859.3">
        <property type="protein sequence ID" value="ENSMICP00000010799.3"/>
        <property type="gene ID" value="ENSMICG00000011858.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000041509.2">
        <property type="protein sequence ID" value="ENSMICP00000022944.2"/>
        <property type="gene ID" value="ENSMICG00000011858.3"/>
    </dbReference>
    <dbReference type="CTD" id="5627"/>
    <dbReference type="GeneTree" id="ENSGT00940000154035"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007596">
        <property type="term" value="P:blood coagulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042730">
        <property type="term" value="P:fibrinolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00110">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000240">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000426">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000748">
        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000077">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.740.10:FF:000001">
        <property type="entry name" value="vitamin K-dependent protein S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.740.10">
        <property type="entry name" value="Coagulation Factor IX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017857">
        <property type="entry name" value="Coagulation_fac-like_Gla_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051145">
        <property type="entry name" value="GAS-SHBG-PROS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035972">
        <property type="entry name" value="GLA-like_dom_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000294">
        <property type="entry name" value="GLA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001791">
        <property type="entry name" value="Laminin_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040">
        <property type="entry name" value="LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24040:SF0">
        <property type="entry name" value="VITAMIN K-DEPENDENT PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00594">
        <property type="entry name" value="Gla"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin_G_1"/>
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    </dbReference>
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        <property type="entry name" value="Laminin_G_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00001">
        <property type="entry name" value="GLABLOOD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00069">
        <property type="entry name" value="GLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00282">
        <property type="entry name" value="LamG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
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    <dbReference type="SUPFAM" id="SSF57630">
        <property type="entry name" value="GLA-domain"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
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        <property type="entry name" value="ASX_HYDROXYL"/>
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    </dbReference>
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        <property type="entry name" value="EGF_1"/>
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        <property type="entry name" value="EGF_2"/>
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        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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        <property type="entry name" value="EGF_CA"/>
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        <property type="entry name" value="GLA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50998">
        <property type="entry name" value="GLA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50025">
        <property type="entry name" value="LAM_G_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0094">Blood coagulation</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="13 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 17" id="KW-0245">EGF-like domain</keyword>
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    <keyword evidence="4" id="KW-0301">Gamma-carboxyglutamic acid</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0356">Hemostasis</keyword>
    <keyword evidence="15" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044680962" description="Vitamin K-dependent protein S" evidence="18">
        <location>
            <begin position="25"/>
            <end position="675"/>
        </location>
    </feature>
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        <location>
            <begin position="41"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="117"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin G" evidence="19">
        <location>
            <begin position="299"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022696"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023084"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50025"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010799.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="675" mass="74966" checksum="9E4FF3B135EFADFF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XH84</accession>
    <name>A0A8C5XH84_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">LOC105862787</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024692">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XH84"/>
    <dbReference type="Ensembl" id="ENSMICT00000053420.2">
        <property type="protein sequence ID" value="ENSMICP00000022102.2"/>
        <property type="gene ID" value="ENSMICG00000027867.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005809"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="192"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022102.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="223" mass="27274" checksum="1A6B29A04C101B39" modified="2022-01-19" version="1">NGQCPDVFGSGLQAAAIMAFLAPVAYLTHQQVWRFYKWALCHLESWCIHRDKYWYFTCLMRARFEEHKNEKDMRKAIQLLREAEEEFWFRQHPQPYIFPDSPGGTSYKRYECYKLPEWCLDHWHPSEKAMYPDYFAKREQWKKLRRESWAREVKQLQEETPPGGPLPEALPPAQKEGDLPQLWWHIVTRPRDRPVERERERERERERERERERDRDLTIHACK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHR2</accession>
    <name>A0A8C5XHR2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family with sequence similarity 72 member A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">FAM72A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM72 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615818.1">
        <property type="nucleotide sequence ID" value="XM_012760364.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615821.1">
        <property type="nucleotide sequence ID" value="XM_012760367.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012615828.1">
        <property type="nucleotide sequence ID" value="XM_012760374.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XHR2"/>
    <dbReference type="Ensembl" id="ENSMICT00000052718.2">
        <property type="protein sequence ID" value="ENSMICP00000023720.2"/>
        <property type="gene ID" value="ENSMICG00000029197.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105868939"/>
    <dbReference type="KEGG" id="mmur:105868939"/>
    <dbReference type="CTD" id="729533"/>
    <dbReference type="GeneTree" id="ENSGT00390000005106"/>
    <dbReference type="OrthoDB" id="2526683at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026768">
        <property type="entry name" value="YPEH2ZP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31841:SF1">
        <property type="entry name" value="PROTEIN FAM72A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14976">
        <property type="entry name" value="YPEH2ZP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023720.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="149" mass="16631" checksum="32E3CD1364F0F460" modified="2022-01-19" version="1">MSANSCSFKDRCVSILCCKFCKQVLSSRGMKAVLLADTEIDLFSTDIPPTNAVDFIGRCYFTKICKCKLKDIACLKCGNIVGYHVIVPCTSCLLSCNNGHFWMFHSQAVYDINRLDSTGVNVLLWGNLPEIEENTDEDLLDISAEECIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHV5</accession>
    <name>A0A8C5XHV5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BolA family member 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">BOLA2B</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XHV5"/>
    <dbReference type="Ensembl" id="ENSMICT00000036727.2">
        <property type="protein sequence ID" value="ENSMICP00000024088.1"/>
        <property type="gene ID" value="ENSMICG00000037709.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000047760"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="148" mass="16594" checksum="F258B7E122DF0DBF" modified="2022-01-19" version="1">MASAETLDCWKARLRTSFTRALVRAEVDAPAEVASVRAEGGVVRLGAGVPSPLGFRPSWTAAMELSAEYLREKLQRDLEAEHVEVEDTTPNRCASSFRVLVVSAKFEGKPLLQRHRLVNTCLVDELPHIHAFEQKTLTPEQWAREQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XHW6</accession>
    <name>A0A8C5XHW6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Small nuclear ribonucleoprotein F</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein F</fullName>
        </alternativeName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034843">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XHW6"/>
    <dbReference type="Ensembl" id="ENSMICT00000055177.2">
        <property type="protein sequence ID" value="ENSMICP00000024090.2"/>
        <property type="gene ID" value="ENSMICG00000030494.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154818"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000133">
        <property type="entry name" value="Small nuclear ribonucleoprotein F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="14">
        <location>
            <begin position="45"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024090.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="125" mass="13761" checksum="F29CD2D1DE53541D" modified="2022-01-19" version="1">GLERDLPSRIAFHGTSCSHEGQAAAWLAASSLQHSPVVTMSLPLNPKHLLSGLTGKPVMVKLKWGMEYKAYLVSVDGYMNMQLANTEEYIDGALSGHLGEVLIRCNNALYIRGVEEEEEDGEMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJW7</accession>
    <name>A0A8C5XJW7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromosome 11 open reading frame 54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">C11orf54</name>
        <name evidence="8" type="synonym">C5H11orf54</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJW7"/>
    <dbReference type="Ensembl" id="ENSMICT00000028740.2">
        <property type="protein sequence ID" value="ENSMICP00000029943.1"/>
        <property type="gene ID" value="ENSMICG00000028510.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017214"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17298">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015021">
        <property type="entry name" value="C11orf54_DUF1907"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204:SF1">
        <property type="entry name" value="ESTER HYDROLASE C11ORF54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13204">
        <property type="entry name" value="PTD012 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08925">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01168">
        <property type="entry name" value="DUF1907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DUF1907" evidence="7">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000029943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="265" mass="29391" checksum="B8D8B708ADD5FF35" modified="2022-01-19" version="1">MAIAEFSFHVPSLAELAGVMQKGLKDNFADVQVSVVDCPDLTKEPFNFPVKGICGKTRIAEVGGVPYLLPLVNQKKVYDLNKIAKEIKLPGAFILGAGAGPFQTLGFNAEFMPVIQTESEHKPPVNGSYFARVNPADGGCLLQKYSEKHHDFGCALLANLFASEGQPGKPAEFSSCPLNSDEDVNKWLHFYEMKAPLVCLPVFVSKDPGYDLRLEHTHFFSHHGEGGHYHYDTTPDIVEYLGYFLPAEFLYRIDQPKETHTIGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNT1</accession>
    <name>A0A8C5XNT1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EH domain binding protein 1 like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">EHBP1L1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005855">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000048597.2">
        <property type="protein sequence ID" value="ENSMICP00000038451.2"/>
        <property type="gene ID" value="ENSMICG00000030542.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161027"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21255">
        <property type="entry name" value="CH_EHBP1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000023">
        <property type="entry name" value="EH domain-binding protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022735">
        <property type="entry name" value="bMERB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050540">
        <property type="entry name" value="F-actin_Monoox_Mical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167">
        <property type="entry name" value="CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23167:SF42">
        <property type="entry name" value="EH DOMAIN-BINDING PROTEIN 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12130">
        <property type="entry name" value="bMERB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01203">
        <property type="entry name" value="DUF3585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51848">
        <property type="entry name" value="BMERB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="7">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="1016"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="BMERB" evidence="8">
        <location>
            <begin position="1317"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="987"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1164"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1195"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1272"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038451.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1491" mass="158481" checksum="38048C6C3D780C63" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XQC3</accession>
    <name>A0A8C5XQC3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stathmin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">STMN2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Lamellipodium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the stathmin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012993">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03012995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595468.1">
        <property type="nucleotide sequence ID" value="XM_012740014.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XQC3"/>
    <dbReference type="SMR" id="A0A8C5XQC3"/>
    <dbReference type="Ensembl" id="ENSMICT00000036817.2">
        <property type="protein sequence ID" value="ENSMICP00000039371.1"/>
        <property type="gene ID" value="ENSMICG00000026842.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105857578"/>
    <dbReference type="KEGG" id="mmur:105857578"/>
    <dbReference type="CTD" id="11075"/>
    <dbReference type="GeneTree" id="ENSGT01030000234597"/>
    <dbReference type="OrthoDB" id="5986631at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030426">
        <property type="term" value="C:growth cone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990090">
        <property type="term" value="P:cellular response to nerve growth factor stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007026">
        <property type="term" value="P:negative regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031115">
        <property type="term" value="P:negative regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010977">
        <property type="term" value="P:negative regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031175">
        <property type="term" value="P:neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031117">
        <property type="term" value="P:positive regulation of microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030514">
        <property type="entry name" value="Stathmin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000956">
        <property type="entry name" value="Stathmin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036002">
        <property type="entry name" value="Stathmin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104">
        <property type="entry name" value="STATHMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10104:SF18">
        <property type="entry name" value="STATHMIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00836">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002285">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00345">
        <property type="entry name" value="STATHMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101494">
        <property type="entry name" value="Stathmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00563">
        <property type="entry name" value="STATHMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01041">
        <property type="entry name" value="STATHMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51663">
        <property type="entry name" value="STATHMIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="81"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="179" mass="20828" checksum="F9A258A1B57E620D" modified="2022-01-19" version="1">MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XSN8</accession>
    <name>A0A8C5XSN8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Polypeptide N-acetylgalactosaminyltransferase</fullName>
            <ecNumber evidence="19">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Protein-UDP acetylgalactosaminyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">GALNT16</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23956"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12788"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:53604"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = a 3-O-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:52424"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:67138"/>
            <dbReference type="ChEBI" id="CHEBI:87075"/>
            <dbReference type="EC" id="2.4.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 19">Golgi apparatus membrane</location>
            <topology evidence="2 19">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="19"/>
    <dbReference type="EMBL" id="ABDC03003994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003995">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003996">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003997">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636615.1">
        <property type="nucleotide sequence ID" value="XM_012781161.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSN8"/>
    <dbReference type="Ensembl" id="ENSMICT00000032457.2">
        <property type="protein sequence ID" value="ENSMICP00000032230.1"/>
        <property type="gene ID" value="ENSMICG00000009611.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070479.1">
        <property type="protein sequence ID" value="ENSMICP00000040733.1"/>
        <property type="gene ID" value="ENSMICG00000009611.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105880263"/>
    <dbReference type="CTD" id="57452"/>
    <dbReference type="GeneTree" id="ENSGT00940000158846"/>
    <dbReference type="OrthoDB" id="429263at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000041">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000020">
        <property type="entry name" value="Polypeptide N-acetylgalactosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF3">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 19" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12 19" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 19" id="KW-0430">Lectin</keyword>
    <keyword evidence="15 19" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="21">
        <location>
            <begin position="432"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="558" mass="63133" checksum="06809142CEE7CF16" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XT24</accession>
    <name>A0A8C5XT24_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">18 kDa Sin3-associated polypeptide</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XT24"/>
    <dbReference type="Ensembl" id="ENSMICT00000069791.1">
        <property type="protein sequence ID" value="ENSMICP00000040875.1"/>
        <property type="gene ID" value="ENSMICG00000041964.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000003152"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00030511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="154" mass="17614" checksum="AA7ABC9BBCB39173" modified="2022-01-19" version="1">MDGFSCRNIPSSELQVYTWLDATLKELTSLVKEVNPEARKKGTHFNFAIEIGSTMSGRKRTDDSMILQSQKFQIGDYLDIVITPPNRAPPPSGCTRTLLNSIYYFLNLFFGQFCKISLHVLFPPVMIAIKPLNSKQIIMHLFRSLDLDVLCYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XT29</accession>
    <name>A0A8C5XT29_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ZDHHC15</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03033796">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610804.1">
        <property type="nucleotide sequence ID" value="XM_012755350.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XT29"/>
    <dbReference type="Ensembl" id="ENSMICT00000068199.1">
        <property type="protein sequence ID" value="ENSMICP00000040669.1"/>
        <property type="gene ID" value="ENSMICG00000001081.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866161"/>
    <dbReference type="KEGG" id="mmur:105866161"/>
    <dbReference type="CTD" id="158866"/>
    <dbReference type="GeneTree" id="ENSGT00940000158214"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="129"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="337" mass="39304" checksum="601658E734FB759F" modified="2022-01-19" version="1">MRRGWKMALSGGLRCCRRVLSWVPVLVIVLVVLWSYYAYVFELCLVTVLSPAEKVIYLILYHAIFVFFAWTYWKSIFTLPQQPNQKFHLSYTDKERYENEERPEVQKQMLFDMAKKLPVYTRTGSGAVRFCDRCHLIKPDRCHHCSVCAMCVLKMDHHCPWVNNCIGFSNYKFFLQFLAYSVLYCLYIATTVFSYFIKYWRGELPSVRSKFHVLFLLFVACMFFVSLVILFGYHCWLVSRNKTTLEAFCTPVFTSGPEKNGFNLGFIKNIQQVFGDNKKFWLIPIGSSPGDGHSFPMRSMNESQNPLLANEEPWEDNEDDSQDYPEGSSSLAVETET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTL3</accession>
    <name>A0A8C5XTL3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">AT-rich interaction domain 5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ARID5A</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012642363.1">
        <property type="nucleotide sequence ID" value="XM_012786909.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5XTL3"/>
    <dbReference type="Ensembl" id="ENSMICT00000066005.1">
        <property type="protein sequence ID" value="ENSMICP00000041248.1"/>
        <property type="gene ID" value="ENSMICG00000001964.3"/>
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    <dbReference type="GeneID" id="105883644"/>
    <dbReference type="KEGG" id="mmur:105883644"/>
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    <dbReference type="GeneTree" id="ENSGT00940000161253"/>
    <dbReference type="OrthoDB" id="1938591at2759"/>
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        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0050681">
        <property type="term" value="F:nuclear androgen receptor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0030331">
        <property type="term" value="F:nuclear estrogen receptor binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046965">
        <property type="term" value="F:nuclear retinoid X receptor binding"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0046966">
        <property type="term" value="F:nuclear thyroid hormone receptor binding"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="ARID_ARID5A"/>
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        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARID/SWI1_ChromRemod"/>
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    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
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    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
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        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 5A"/>
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        <property type="entry name" value="RBP-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="55"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="440"/>
            <end position="449"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="596" mass="64502" checksum="B8945BC81B17DA0B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XTN7</accession>
    <name>A0A8C5XTN7_MICMU</name>
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        <recommendedName>
            <fullName evidence="16">Semaphorin-4D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">SEMA4D</name>
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    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the semaphorin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014031">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XTN7"/>
    <dbReference type="Ensembl" id="ENSMICT00000065850.1">
        <property type="protein sequence ID" value="ENSMICP00000040999.1"/>
        <property type="gene ID" value="ENSMICG00000001178.3"/>
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    <dbReference type="GeneTree" id="ENSGT00940000159594"/>
    <dbReference type="OMA" id="PSRGWIQ"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045499">
        <property type="term" value="F:chemorepellent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030215">
        <property type="term" value="F:semaphorin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070486">
        <property type="term" value="P:leukocyte aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001755">
        <property type="term" value="P:neural crest cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043931">
        <property type="term" value="P:ossification involved in bone maturation"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048672">
        <property type="term" value="P:positive regulation of collateral sprouting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051897">
        <property type="term" value="P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048814">
        <property type="term" value="P:regulation of dendrite morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071526">
        <property type="term" value="P:semaphorin-plexin signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11259">
        <property type="entry name" value="Sema_4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000120">
        <property type="entry name" value="Semaphorin 4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1680.10:FF:000013">
        <property type="entry name" value="Semaphorin 4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000647">
        <property type="entry name" value="Semaphorin-4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1680.10">
        <property type="entry name" value="ligand-binding face of the semaphorins, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013151">
        <property type="entry name" value="Immunoglobulin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002165">
        <property type="entry name" value="Plexin_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016201">
        <property type="entry name" value="PSI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036352">
        <property type="entry name" value="Semap_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027231">
        <property type="entry name" value="Semaphorin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036">
        <property type="entry name" value="SEMAPHORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11036:SF18">
        <property type="entry name" value="SEMAPHORIN-4D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00047">
        <property type="entry name" value="ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01437">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01403">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00423">
        <property type="entry name" value="PSI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00630">
        <property type="entry name" value="Sema"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103575">
        <property type="entry name" value="Plexin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101912">
        <property type="entry name" value="Sema domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Sema" evidence="21">
        <location>
            <begin position="19"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="20">
        <location>
            <begin position="554"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="669"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="795"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="862" mass="95595" checksum="F19DCC2AFAE2491B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUZ2</accession>
    <name>A0A8C5XUZ2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004513">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004514">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUZ2"/>
    <dbReference type="Ensembl" id="ENSMICT00000067314.1">
        <property type="protein sequence ID" value="ENSMICP00000041679.1"/>
        <property type="gene ID" value="ENSMICG00000047242.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182838"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="52"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="368" mass="41101" checksum="D447F0D754A8B46C" modified="2022-01-19" version="1">MSDIVEKTLTALPGLFLQNQPGGGPAAAKSSFSSRLGGLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRRALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVDFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTIYSIYPKSELLEKAAKCIGKFVLSPRINLKYLGSYSGSSTSDDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XVA3</accession>
    <name>A0A8C5XVA3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Wee1-like protein kinase</fullName>
            <ecNumber evidence="14">2.7.10.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">WEE2</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.10.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10597"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.10.2" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03015150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000042038.1"/>
        <property type="gene ID" value="ENSMICG00000045942.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000158803"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
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        <property type="term" value="C:cytosol"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:non-membrane spanning protein tyrosine kinase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:female meiotic nuclear division"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035038">
        <property type="term" value="P:female pronucleus assembly"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:1900194">
        <property type="term" value="P:negative regulation of oocyte maturation"/>
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        <property type="term" value="P:positive regulation of phosphorylation"/>
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    <dbReference type="GO" id="GO:0080154">
        <property type="term" value="P:regulation of fertilization"/>
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    <dbReference type="GO" id="GO:0060631">
        <property type="term" value="P:regulation of meiosis I"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000115">
        <property type="entry name" value="Wee1-like kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000217">
        <property type="entry name" value="Wee1-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CC_SR_Kinase"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Protein_kinase_ATP_BS"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="Wee1-like_protein_kinase"/>
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        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
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    </dbReference>
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        <property type="entry name" value="WEE1-LIKE PROTEIN KINASE 2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Wee1-like_protein_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
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    <keyword evidence="4 14 16" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="217"/>
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        </location>
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        <location>
            <begin position="1"/>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="344"/>
        </location>
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    <feature type="binding site" evidence="16">
        <location>
            <begin position="223"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16 18">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="17">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042038.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="569" mass="63278" checksum="8BCDF18B1B74F9FE" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="2">Galectin</fullName>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="Galectin_CRD"/>
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    <dbReference type="PANTHER" id="PTHR11346">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11346:SF15">
        <property type="entry name" value="PLACENTAL PROTEIN 13-LIKE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00276">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Galectin" evidence="3">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU102079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="141" mass="16108" checksum="9D6E9CC4C8516FB7" modified="2022-01-19" version="1">MSCLQVPHTQCVSFSVGSCVIIKGTPPVSFDKDPQLQVDFHTGTNDKSDIAFHFRVYFGRHVVMNSFEEGGWKHEVRLTHMPFAQGRAFELRILVLHDEYQVVVNGQHYFGFAHRLKPESVKMVHVWRDVSLTSVNVVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYN5</accession>
    <name>A0A8C5XYN5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OCA2 melanosomal transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">OCA2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013546">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013548">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013549">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013550">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020144648.1">
        <property type="nucleotide sequence ID" value="XM_020289059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYN5"/>
    <dbReference type="Ensembl" id="ENSMICT00000060508.1">
        <property type="protein sequence ID" value="ENSMICP00000043252.1"/>
        <property type="gene ID" value="ENSMICG00000000034.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000064143.1">
        <property type="protein sequence ID" value="ENSMICP00000044170.1"/>
        <property type="gene ID" value="ENSMICG00000000034.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105868891"/>
    <dbReference type="CTD" id="4948"/>
    <dbReference type="GeneTree" id="ENSGT01030000234550"/>
    <dbReference type="OrthoDB" id="442352at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:endosome membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033162">
        <property type="term" value="C:melanosome membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035752">
        <property type="term" value="P:lysosomal lumen pH elevation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006583">
        <property type="term" value="P:melanin biosynthetic process from tyrosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030318">
        <property type="term" value="P:melanocyte differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01116">
        <property type="entry name" value="P_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051475">
        <property type="entry name" value="Diverse_Ion_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43568:SF1">
        <property type="entry name" value="P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="728"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="819"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="349"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="845" mass="93143" checksum="466E5B4A500B1652" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y441</accession>
    <name>A0A8C5Y441_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein kinase Kist</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03005296">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005297">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y441"/>
    <dbReference type="Ensembl" id="ENSMICT00000064090.1">
        <property type="protein sequence ID" value="ENSMICP00000045226.1"/>
        <property type="gene ID" value="ENSMICG00000046769.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157769"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071598">
        <property type="term" value="C:neuronal ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046825">
        <property type="term" value="P:regulation of protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12465">
        <property type="entry name" value="RRM_UHMK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000322">
        <property type="entry name" value="Serine/threonine-protein kinase Kist isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000241">
        <property type="entry name" value="Serine/threonine-protein kinase Kist isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034372">
        <property type="entry name" value="UHMK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034371">
        <property type="entry name" value="UHMK1_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46962">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE KIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46962:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE KIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034125370" description="Serine/threonine-protein kinase Kist" evidence="2">
        <location>
            <begin position="20"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="237"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37542" checksum="A4CEC17B461865D9" modified="2022-01-19" version="1">LTLILLLFFTIHFSPNVPSRCLLLELLDVSASELLLYSSHQGCSMWMIQHCARDVLEALAFLHHEGYVHADLKPRNILWSAENECFKLIDFGLSFKEGNQDEKYIQTDRYRAPEAELQNCLAQAGLQSDTECTSAVDLWSLGIILLEMFSGMKLKHTVRSQEWKANSSAIIDHIFASKAVVNAAIPAYHLRDLMKSMLHDDPSRRIPAEMALCSAFFSIPFAPHIEDLVMLPTPVLRLLNVLDDDYLENEEEYEDVVQGVKEECQKYGPVVSLLVPKENPGRGQVFVEYANAGDSKAAQKLLTGRMFDGKFVVATFYPLSAYKRGYLYQTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y4P9</accession>
    <name>A0A8C5Y4P9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lys-63-specific deubiquitinase</fullName>
            <ecNumber evidence="10">3.4.19.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">BRCC3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the BRCA1-A complex, interacts directly with ABRAXAS1 and BABAM2. Component of the BRISC complex, at least composed of ABRAXAS2, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Identified in a complex with SHMT2 and the other subunits of the BRISC complex. In the BRISC complex, interacts directly with ABRAXAS2. Identified in a complex with ABRAXAS2 and NUMA1. The BRISC complex interacts with the CSN complex. Component of the BRCA1/BRCA2 containing complex (BRCC), which also contains BRCA1, BRCA2, BARD1, BABAM2 and RAD51. BRCC is a ubiquitin E3 ligase complex that enhances cellular survival following DNA damage. Interacts with BRCA1. Binds polyubiquitin. Interacts with PWWP2B. Interacts with HDAC1; this interaction is enhanced in the presence of PWWP2B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
            <location evidence="10">Cytoskeleton</location>
            <location evidence="10">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M67A family. BRCC36 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.-" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03035501">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035502">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035503">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140761.1">
        <property type="nucleotide sequence ID" value="XM_020285172.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020140762.1">
        <property type="nucleotide sequence ID" value="XM_020285173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y4P9"/>
    <dbReference type="Ensembl" id="ENSMICT00000068594.1">
        <property type="protein sequence ID" value="ENSMICP00000045764.1"/>
        <property type="gene ID" value="ENSMICG00000036150.2"/>
    </dbReference>
    <dbReference type="CTD" id="79184"/>
    <dbReference type="GeneTree" id="ENSGT00390000000360"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070531">
        <property type="term" value="C:BRCA1-A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045739">
        <property type="term" value="P:positive regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010212">
        <property type="term" value="P:response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08068">
        <property type="entry name" value="MPN_BRCC36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000015">
        <property type="entry name" value="Lys-63-specific deubiquitinase BRCC36 isoform 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040749">
        <property type="entry name" value="BRCC36_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033860">
        <property type="entry name" value="MPN_BRCC36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18110">
        <property type="entry name" value="BRCC36_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="12">
        <location>
            <begin position="12"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="259"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="291" mass="33164" checksum="4A66AAFFB21A930D" modified="2022-01-19" version="1">MAVQVVQAVQAVHLESDAFLVCLNHALSTEKEEVMGLCIGELNDDARTDSKFAYAGSEMRTVAEKIDTVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQSFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSEYERIEIPIHIVPHVTIGKVCLESAVELPKILCQEEQDAYRRIHSLTHLDSVTKIHNGSVFTKNLCSQMSAVSGPLLQWLEDRLEQNQQHLQELQQEKEELMQELSSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y616</accession>
    <name>A0A8C5Y616_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Wiskott-Aldrich syndrome protein family member</fullName>
            <shortName evidence="7">WASP family protein member</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">WASF3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Binds actin and the Arp2/3 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017886">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633982.1">
        <property type="nucleotide sequence ID" value="XM_012778528.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633983.1">
        <property type="nucleotide sequence ID" value="XM_012778529.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633984.1">
        <property type="nucleotide sequence ID" value="XM_012778530.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y616"/>
    <dbReference type="Ensembl" id="ENSMICT00000054963.2">
        <property type="protein sequence ID" value="ENSMICP00000021425.2"/>
        <property type="gene ID" value="ENSMICG00000027798.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000070737.1">
        <property type="protein sequence ID" value="ENSMICP00000045983.1"/>
        <property type="gene ID" value="ENSMICG00000027798.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878791"/>
    <dbReference type="KEGG" id="mmur:105878791"/>
    <dbReference type="CTD" id="10810"/>
    <dbReference type="GeneTree" id="ENSGT00950000182962"/>
    <dbReference type="OrthoDB" id="1060785at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097386">
        <property type="term" value="C:glial cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031209">
        <property type="term" value="C:SCAR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098885">
        <property type="term" value="P:modification of postsynaptic actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014003">
        <property type="term" value="P:oligodendrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031643">
        <property type="term" value="P:positive regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22073">
        <property type="entry name" value="WH2_WAVE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000012">
        <property type="entry name" value="Wiskott-Aldrich syndrome protein family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF7">
        <property type="entry name" value="ACTIN-BINDING PROTEIN WASF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00246">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="9">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="502" mass="55161" checksum="0A0AD66C1E3D6257" modified="2022-01-19" version="1">MPLVKRNIEPRHLCRGALPEGITSELECVTNSTLAAIIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDINMKKAFKSSTVQDQQVVSKNSIPNPVADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSYFFDLWKEKMLQDTEDKRKEKRRQKEQKRIDGTTREVKKVRKARNRRQEWNMMAYDKELRPDNRLSQSVYHGASSEGSLSPDTRSHASDVTDYSYPATPNHSLHAQPATPSYAAAGEAPPHGPASQAPEHEYRPPSASARHMALNRPQQPPPPPPPQAPEGSQASAPLAPADYGMLPAQIIEYYNPSGPPPPPPPPVIPSAQTAFVSPLQMPMQPAFPAPAGTTYTAPPHPPAGLLAAAPPPPGPPPPPPGPPGPGASLSPSPMHGPPAAEARRQEPAQPPISDARSDLLAAIRMGIQLKKVQEQREQEAKREPVGNDVATILSRRIAVEYSDSEDDSEFDENDWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YAS6</accession>
    <name>A0A8C5YAS6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lymphocyte antigen 6 family member L</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LY6L</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03013476">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YAS6"/>
    <dbReference type="Ensembl" id="ENSMICT00000060715.1">
        <property type="protein sequence ID" value="ENSMICP00000048680.1"/>
        <property type="gene ID" value="ENSMICG00000046185.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154560"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23551">
        <property type="entry name" value="TFP_LU_ECD_Ly6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.60.10">
        <property type="entry name" value="CD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051445">
        <property type="entry name" value="LY6H/LY6L_nAChR_modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045860">
        <property type="entry name" value="Snake_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32217">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32217:SF2">
        <property type="entry name" value="LYMPHOCYTE ANTIGEN 6L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00134">
        <property type="entry name" value="LU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57302">
        <property type="entry name" value="Snake toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034756149" evidence="9">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="10">
        <location>
            <begin position="28"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="138" mass="15406" checksum="0155349488642964" modified="2022-01-19" version="1">MRCFGVILWAFLGSPEFAGLWITPASNLTCYQCFKVSSPANCLPVRCLSTDQVCVSNEVVFFTKHSTRVLLSKRCAPRCPNTNSKFKWSLGSGVNSLMTRHCCSRNLCNRAPTTEEGLWAQPEMLLLQVGLSLLWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YCU5</accession>
    <name>A0A8C5YCU5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Retinol dehydrogenase 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RDH5</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009870">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608434.1">
        <property type="nucleotide sequence ID" value="XM_012752980.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608440.1">
        <property type="nucleotide sequence ID" value="XM_012752986.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YCU5"/>
    <dbReference type="Ensembl" id="ENSMICT00000059376.1">
        <property type="protein sequence ID" value="ENSMICP00000049496.1"/>
        <property type="gene ID" value="ENSMICG00000043819.1"/>
    </dbReference>
    <dbReference type="GeneID" id="109729192"/>
    <dbReference type="CTD" id="5959"/>
    <dbReference type="GeneTree" id="ENSGT00940000161168"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004745">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047044">
        <property type="term" value="F:androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047023">
        <property type="term" value="F:androsterone dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001523">
        <property type="term" value="P:retinoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000074">
        <property type="entry name" value="Retinol dehydrogenase type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313:SF12">
        <property type="entry name" value="RETINOL DEHYDROGENASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43313">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150580" evidence="4">
        <location>
            <begin position="26"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="318" mass="34892" checksum="4BD4A0A4723CC70A" modified="2022-01-19" version="1">MWLPLLLGALLWAVLWLLRDRQSLPASNAFVFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAEDLQRLASSHLHTTLLDVTDPQSVHQAAKWVETHVREAGLFGLVNNAGVAGIIGPTPWLTQDDFHRVLNVNTLGPIGVTLALLPLLQQARGRVVNITSVLGRLAANGGGYCISKFGLEAFSDSLRRDMAHFGVRVCIVEPGFFRTPVTNLESLENTLQACWARLPPATQALYGEAFLTKYLKVQRRIMNLICDPDLTKVSKCVEHALTARHPRTRYSPGWDAKLLWLPASYLPASLVDAVLTWVLPKPAQAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YD92</accession>
    <name>A0A8C5YD92_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein 183A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TMEM183A</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM183 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029857">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012599867.1">
        <property type="nucleotide sequence ID" value="XM_012744413.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YD92"/>
    <dbReference type="Ensembl" id="ENSMICT00000066383.1">
        <property type="protein sequence ID" value="ENSMICP00000049700.1"/>
        <property type="gene ID" value="ENSMICG00000037686.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860040"/>
    <dbReference type="CTD" id="92703"/>
    <dbReference type="GeneTree" id="ENSGT00390000009310"/>
    <dbReference type="OrthoDB" id="5955317at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026509">
        <property type="entry name" value="TMEM183"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20988:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 183A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="375" mass="42769" checksum="6E4A4CABB02EF427" modified="2022-01-19" version="1">MARGPGPLDRPRPDAVAMPKRGKRLKFRAHDACSGRVTVADYANSDPAVVRSGRVKKAIANAVQQEVKSLCGLEASQVPAEEALSGAGEPCDIIDSSDEMDAQEESIHERTVSRKKKSKRHKDLDGAGGEEYPMDIWLLLASYIRPEDIVNFSLICKNAWTVTCTAAFWTRLYRRHYTLDASLPLRLRPESMEKLRCLRACVIRSLYHMYEPFAARISKNPAIPESTPSTLKNSKCLLFWCRKIVGNRQEPMWEFNFKFKKQSPRLKSKCMGGLQPPIQYEDVHTNPDQDCCLLQVTTLNFIFIPIVMGMIFTLFTINVSTDMRHHRVRLVFQDSPVHGGRKLRSEQGVQVILDPVHSVRLFDWWHPQYPFSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEV3</accession>
    <name>A0A8C5YEV3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Growth differentiation factor 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">GDF7</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TGF-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011967">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEV3"/>
    <dbReference type="Ensembl" id="ENSMICT00000065065.1">
        <property type="protein sequence ID" value="ENSMICP00000050035.1"/>
        <property type="gene ID" value="ENSMICG00000044629.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160140"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032924">
        <property type="term" value="P:activin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007411">
        <property type="term" value="P:axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030509">
        <property type="term" value="P:BMP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048754">
        <property type="term" value="P:branching morphogenesis of an epithelial tube"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045165">
        <property type="term" value="P:cell fate commitment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030855">
        <property type="term" value="P:epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048853">
        <property type="term" value="P:forebrain morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022612">
        <property type="term" value="P:gland morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030901">
        <property type="term" value="P:midbrain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060571">
        <property type="term" value="P:morphogenesis of an epithelial fold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045666">
        <property type="term" value="P:positive regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060391">
        <property type="term" value="P:positive regulation of SMAD protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001051">
        <property type="term" value="P:positive regulation of tendon cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021509">
        <property type="term" value="P:roof plate formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021527">
        <property type="term" value="P:spinal cord association neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd13766">
        <property type="entry name" value="TGF_beta_GDF5_6_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.90.10:FF:000001">
        <property type="entry name" value="Bone morphogenetic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001839">
        <property type="entry name" value="TGF-b_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001111">
        <property type="entry name" value="TGF-b_propeptide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015615">
        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF160">
        <property type="entry name" value="GROWTH_DIFFERENTIATION FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00688">
        <property type="entry name" value="TGFb_propeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0339">Growth factor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034522593" evidence="11">
        <location>
            <begin position="23"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="12">
        <location>
            <begin position="314"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="447" mass="46838" checksum="0E40F51672F71F94" modified="2022-01-19" version="1">MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPARSSGGGGGGRTLAPAAGASAVPAAVVPEARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGRASAGAAAVSVSGHGRADTITGFADQATQDESAAETGQSFLFDVSSLPDADEVVGAELRVLRRGSPEQGPGSAPAPPLLLLSTCPGAAYSPRLLHSRAAEPLDGARWEVFDVADAVRRHRREPRAPRTFCLLLRAVARPARSPLALRRLGFGWRGGGDAAAEERALLVVSSRSQRKESLFREIRAQARALGAALAAEPPPDPGPGTRSPRVVIGGRRRRRTALAGTRAAAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGVCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFG9</accession>
    <name>A0A8C5YFG9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ZDHHC3</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="ABDC03000336">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03000337">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFG9"/>
    <dbReference type="Ensembl" id="ENSMICT00000072589.1">
        <property type="protein sequence ID" value="ENSMICP00000050648.1"/>
        <property type="gene ID" value="ENSMICG00000049170.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155721"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031669">
        <property type="term" value="P:cellular response to nutrient levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044873">
        <property type="term" value="P:lipoprotein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150032">
        <property type="term" value="P:positive regulation of protein localization to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034165">
        <property type="term" value="P:positive regulation of toll-like receptor 9 signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903546">
        <property type="term" value="P:protein localization to photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036462">
        <property type="term" value="P:TRAIL-activated apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="161"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="332" mass="37681" checksum="351E6D56A28E4CE8" modified="2022-01-19" version="1">MMLIPTHHFRDIERKPEYLQPEKCVPPPYPGPVGTMWFIRDGCGIACAIVTWCLVLYAEFVVLFVMLIPSRDYAYSIINGIVFNLLAFLALASHCRAMLTDPVRTCTEMAFTLLGGSSFPEKLDKPVSGRNKCLLGAVPKGNATKEFIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYIALISLHALIMVGFHFLHCFEEDWTKCSSFSPPTTVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEQLKKEERRWAKKTKWMNMKAVFGHPFSLGWASPFATPDQGKADPYQYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFL2</accession>
    <name>A0A8C5YFL2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006421">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006422">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006423">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006424">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFL2"/>
    <dbReference type="Ensembl" id="ENSMICT00000068309.1">
        <property type="protein sequence ID" value="ENSMICP00000050335.1"/>
        <property type="gene ID" value="ENSMICG00000041854.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286945"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000004">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0552">Olfaction</keyword>
    <keyword evidence="9 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10 11" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="13">
        <location>
            <begin position="43"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="313" mass="35002" checksum="E186945700647533" modified="2022-01-19" version="1">MEVGNHTTVTEFILLGLTKDPTLFLRVVLFMIILCIYLVTISGNLSTIILIRISSQLHHPMHFFLSHLASADLGFSSSVTPNMLVNFLVERNTISYLGCAIQHFSVAFFGTVECFLLAAMAYDRFVAICNPLLYSTKMSTQVCVQLLIVAYLSGFLNASSFTFSFFSLSFCGQNQVNHFFCDFAPLIELSCFDTSVSTAVPSFTAGCVIVVTVFVIVVSYIYILITILKMRSTKGRHKAFSTCTSHLTAVTLFYGTTTFNYLMTKSSTTDQNKVVSVFYMVVIPMLNPIIYSLRNMEIKGALKRELGRKIFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YGH7</accession>
    <name>A0A8C5YGH7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Acetoacetyl-CoA synthetase</fullName>
            <ecNumber evidence="3 11">6.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">AACS</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Converts acetoacetate to acetoacetyl-CoA in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16117"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.16" evidence="3 11"/>
    <dbReference type="EMBL" id="ABDC03024766">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024767">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637601.1">
        <property type="nucleotide sequence ID" value="XM_012782147.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YGH7"/>
    <dbReference type="Ensembl" id="ENSMICT00000064376.1">
        <property type="protein sequence ID" value="ENSMICP00000050111.1"/>
        <property type="gene ID" value="ENSMICG00000046827.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067841.1">
        <property type="protein sequence ID" value="ENSMICP00000047682.1"/>
        <property type="gene ID" value="ENSMICG00000046827.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105880840"/>
    <dbReference type="CTD" id="65985"/>
    <dbReference type="GeneTree" id="ENSGT00940000156044"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032024">
        <property type="term" value="P:positive regulation of insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05943">
        <property type="entry name" value="AACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000037">
        <property type="entry name" value="acetoacetyl-CoA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="13">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="12">
        <location>
            <begin position="110"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="672" mass="74839" checksum="1C529FE7571778B3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YH64</accession>
    <name>A0A8C5YH64_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Disks large homolog 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Synapse-associated protein 97</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DLG1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Apical cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MAGUK family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001030">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001031">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001032">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
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    <sequence length="893" mass="100020" checksum="6D7EC34D2E736B0B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YJW3</accession>
    <name>A0A8C5YJW3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor A domain containing 5B2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">VWA5B2</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012736912.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8C5YJW3"/>
    <dbReference type="Ensembl" id="ENSMICT00000073413.1">
        <property type="protein sequence ID" value="ENSMICP00000051467.1"/>
        <property type="gene ID" value="ENSMICG00000049272.1"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157096"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2"/>
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        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5B2-RELATED"/>
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        <property type="entry name" value="VIT_2"/>
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        </location>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
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                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Weissenberger G."/>
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                <person name="Dudchenko O."/>
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                <person name="Shamim M."/>
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                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="7" key="3">
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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            <location evidence="1">trans-Golgi network membrane</location>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012786538.2"/>
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    <dbReference type="KEGG" id="mmur:105883449"/>
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    <dbReference type="GeneTree" id="ENSGT00950000183040"/>
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    <dbReference type="Proteomes" id="UP000694394">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8C6EHW1_MICMU</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03023267">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EHW1"/>
    <dbReference type="Ensembl" id="ENSMICT00000063412.1">
        <property type="protein sequence ID" value="ENSMICP00000043608.1"/>
        <property type="gene ID" value="ENSMICG00000047285.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034145971" description="GALNS" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="6546" checksum="75533AC16E21AF05" modified="2022-01-19" version="1">MVAVAAATRWRLLLVVLSALGMGAASAPQPPNILLLLMDDVSGDPARGPPRWCPCPPAAGGAARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EI49</accession>
    <name>A0A8C6EI49_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Olfactory receptor family 56 subfamily A member 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">OR56A4</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006437">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006438">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EI49"/>
    <dbReference type="Ensembl" id="ENSMICT00000060018.1">
        <property type="protein sequence ID" value="ENSMICP00000043585.1"/>
        <property type="gene ID" value="ENSMICG00000045298.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161235"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071396">
        <property type="term" value="P:cellular response to lipid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000002">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050402">
        <property type="entry name" value="OR51/52/56-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450">
        <property type="entry name" value="OLFACTORY RECEPTOR 56B1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26450:SF52">
        <property type="entry name" value="OLFACTORY RECEPTOR FAMILY 56 SUBFAMILY A MEMBER 41, PSEUDOGENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01381">
        <property type="entry name" value="7TM_GPCR_Srsx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0552">Olfaction</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="11">
        <location>
            <begin position="44"/>
            <end position="295"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="35093" checksum="36B8179F720AB361" modified="2022-01-19" version="1">MVSSPNNTGTQVTEFLMICFPGMQDTQHWLSIVLAPLLVLALGANFVLLLAIRQEASLHEPMYYLLAILSVLDVILCLTVIPKVLLIFWFNMKPISFAGCFLQMFVMNTFLPMESSTFLVMAYDRYVAICHPLRYPSIITEQFVINAAIFIVFRNLLATLPTPVLAARLNYCASNVVENCICANISVARLSCGDIRLNKLYQFVSVWCLLGSDLVLILLSYCFILKAVMHLQSGGATTKALSTCGSHLILILFFYTLLLVFIFTNKAGKSVPSEVPILLNVLHHLIPPALNPIVYGVRTQEIKQGIMKLLKYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EID3</accession>
    <name>A0A8C6EID3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Formin 1</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="10">Formin-1 isoform X1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">FMN1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="10">Liver</tissue>
        </source>
    </reference>
    <reference evidence="8" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. Cappuccino subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004572">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621776.1">
        <property type="nucleotide sequence ID" value="XM_012766322.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621777.1">
        <property type="nucleotide sequence ID" value="XM_012766323.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621778.1">
        <property type="nucleotide sequence ID" value="XM_012766324.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621779.1">
        <property type="nucleotide sequence ID" value="XM_012766325.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621780.1">
        <property type="nucleotide sequence ID" value="XM_012766326.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621781.1">
        <property type="nucleotide sequence ID" value="XM_012766327.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621782.1">
        <property type="nucleotide sequence ID" value="XM_012766328.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621783.1">
        <property type="nucleotide sequence ID" value="XM_012766329.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621784.1">
        <property type="nucleotide sequence ID" value="XM_012766330.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000060784.1">
        <property type="protein sequence ID" value="ENSMICP00000043019.1"/>
        <property type="gene ID" value="ENSMICG00000004127.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000060897.1">
        <property type="protein sequence ID" value="ENSMICP00000050187.1"/>
        <property type="gene ID" value="ENSMICG00000004127.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000062723.1">
        <property type="protein sequence ID" value="ENSMICP00000044101.1"/>
        <property type="gene ID" value="ENSMICG00000004127.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000068420.1">
        <property type="protein sequence ID" value="ENSMICP00000045371.1"/>
        <property type="gene ID" value="ENSMICG00000004127.3"/>
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        <property type="entry name" value="Formin_Cappuccino_subfam"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDN7</accession>
    <name>A0A8B7EDN7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">F-box and leucine rich repeat protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FBXL3</name>
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    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012737075.2"/>
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        <property type="nucleotide sequence ID" value="XM_012737076.2"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="C:mitochondrion"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016604">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:ubiquitin-protein transferase activity"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22178">
        <property type="entry name" value="F-box_FBXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23957">
        <property type="entry name" value="FBXL3_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box/LRR-repeat protein 3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
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        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224">
        <property type="entry name" value="ES1 PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF18">
        <property type="entry name" value="F-BOX AND LEUCINE RICH REPEAT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="F-box domain"/>
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    </dbReference>
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        <property type="entry name" value="RNI-like"/>
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    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="39"/>
            <end position="79"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EFT9</accession>
    <name>A0A8B7EFT9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane protein 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TMEM11</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in mitochondrial morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TMEM11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020702">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593375.1">
        <property type="nucleotide sequence ID" value="XM_012737921.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EFT9"/>
    <dbReference type="Ensembl" id="ENSMICT00000052182.2">
        <property type="protein sequence ID" value="ENSMICP00000026906.2"/>
        <property type="gene ID" value="ENSMICG00000003895.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856321"/>
    <dbReference type="KEGG" id="mmur:105856321"/>
    <dbReference type="CTD" id="8834"/>
    <dbReference type="GeneTree" id="ENSGT00390000006617"/>
    <dbReference type="OrthoDB" id="9970856at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026120">
        <property type="entry name" value="TMEM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099">
        <property type="entry name" value="PROTEIN PM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15099:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 11, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14972">
        <property type="entry name" value="Mito_morph_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026906.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="192" mass="21467" checksum="9969BF581D83CE07" modified="2022-01-19" version="1">MAAWGRRRLGPGSGGGGARERVSLSATDCYIVHEIYNGENAQDQFEYELEQALEAQYKYIVIEPTRIGDETARWITVGNCLHKTAVLAGTACLFTPLALPLDYSHYVSLPAGVLSLACCTLYGISWQFDPCCKYQVEYDAYKLSRLPLHTLTSSTPVVLVRKDDLHRKRLHNTIALAALVYCVKKIYELYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ERE6</accession>
    <name>A0A8B7ERE6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Syntaxin-1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="primary">STX1A</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
            <location evidence="1">Synaptic vesicle membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Synapse</location>
            <location evidence="18">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021097">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597681.2">
        <property type="nucleotide sequence ID" value="XM_012742227.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ERE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000036304.2">
        <property type="protein sequence ID" value="ENSMICP00000022100.2"/>
        <property type="gene ID" value="ENSMICG00000008224.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858842"/>
    <dbReference type="KEGG" id="mmur:105858842"/>
    <dbReference type="CTD" id="6804"/>
    <dbReference type="GeneTree" id="ENSGT01030000234627"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030424">
        <property type="term" value="C:axon"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070044">
        <property type="term" value="C:synaptobrevin 2-SNAP-25-syntaxin-1a complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019855">
        <property type="term" value="F:calcium channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019869">
        <property type="term" value="F:chloride channel inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030073">
        <property type="term" value="P:insulin secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000463">
        <property type="term" value="P:positive regulation of excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001956">
        <property type="term" value="P:positive regulation of neurotransmitter secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010807">
        <property type="term" value="P:regulation of synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048488">
        <property type="term" value="P:synaptic vesicle endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016079">
        <property type="term" value="P:synaptic vesicle exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15880">
        <property type="entry name" value="SNARE_syntaxin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000042">
        <property type="entry name" value="Syntaxin 11b, tandem duplicate 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000005">
        <property type="entry name" value="Syntaxin 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF84">
        <property type="entry name" value="SYNTAXIN-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15 22" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="16 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0532">Neurotransmitter transport</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0770">Synapse</keyword>
    <keyword evidence="9" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="10 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0832">Ubl conjugation</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="25">
        <location>
            <begin position="192"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="22">
        <location>
            <begin position="68"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00040530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00046172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022100.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="288" mass="33087" checksum="8F9287EB9E3BACAA" modified="2022-01-19" version="1">MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIVIASTFGGIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2K1</accession>
    <name>A0A8B7F2K1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">THAP domain-containing protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">THAP5</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015350">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601191.2">
        <property type="nucleotide sequence ID" value="XM_012745737.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F2K1"/>
    <dbReference type="Ensembl" id="ENSMICT00000039136.2">
        <property type="protein sequence ID" value="ENSMICP00000030216.2"/>
        <property type="gene ID" value="ENSMICG00000037373.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105860769"/>
    <dbReference type="CTD" id="168451"/>
    <dbReference type="GeneTree" id="ENSGT00940000162392"/>
    <dbReference type="OrthoDB" id="5982876at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002020">
        <property type="term" value="F:protease binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045786">
        <property type="term" value="P:negative regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052224">
        <property type="entry name" value="THAP_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006612">
        <property type="entry name" value="THAP_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927">
        <property type="entry name" value="AGAP005574-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46927:SF1">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05485">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00692">
        <property type="entry name" value="DM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00980">
        <property type="entry name" value="THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50950">
        <property type="entry name" value="ZF_THAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="THAP-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="351"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030216.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="394" mass="45214" checksum="481DD3D8CAE712F2" modified="2022-01-19" version="1">MPRYCAAICCKNRRGRNSKDRKLSFYPFPLHDKERLEKWLKNMKRDSWVPSKYQFLCSDHFTPDSLDIRWGIRYLKQTAVPTIFSLPEDNQGKDPSKKKPQKKKLENEKEVCLKAKSEESHALNEANKNVVNTDMPPERAELLDSSGLLKPQAPTTGIIQNNMLTLNLVKQDTGKPESTLETSVNQDISISGFHTSFENLNSTTITLTTSNSEGIHQALETQEVLEITNHLANPSLTNNSVEIKSTQEKPFLFSTINQTVEELNTNKESIIAIFVPAENSKPVVNSFISARKETMEMEDTDINDSLYKDVDYGTEVLQIEHSYCRQDVNKEHLWQKVSKLHSKITLLELQEQQTLGRLKSLEALVRQLKQENWLSEENVKIIENHFTTYEVTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F3A0</accession>
    <name>A0A8B7F3A0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Glucagon-like peptide 1 receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">GLP1R</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">May form homodimers and heterodimers with GIPR.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03007426">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602402.1">
        <property type="nucleotide sequence ID" value="XM_012746948.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F3A0"/>
    <dbReference type="Ensembl" id="ENSMICT00000017281.3">
        <property type="protein sequence ID" value="ENSMICP00000015740.2"/>
        <property type="gene ID" value="ENSMICG00000017281.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861452"/>
    <dbReference type="KEGG" id="mmur:105861452"/>
    <dbReference type="CTD" id="2740"/>
    <dbReference type="GeneTree" id="ENSGT00940000161009"/>
    <dbReference type="OrthoDB" id="5967113at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004967">
        <property type="term" value="F:glucagon receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044508">
        <property type="term" value="F:glucagon-like peptide 1 receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017046">
        <property type="term" value="F:peptide hormone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045777">
        <property type="term" value="P:positive regulation of blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15268">
        <property type="entry name" value="7tmB1_GLP1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000105">
        <property type="entry name" value="Glucagon like peptide 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1240.10:FF:000013">
        <property type="entry name" value="Glucagon like peptide 1 receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1240.10">
        <property type="entry name" value="GPCR, family 2, extracellular hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047033">
        <property type="entry name" value="GLP1R_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050332">
        <property type="entry name" value="GPCR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036445">
        <property type="entry name" value="GPCR_2_extracell_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001879">
        <property type="entry name" value="GPCR_2_extracellular_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003290">
        <property type="entry name" value="GPCR_2_GLP1/glucagon_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003292">
        <property type="entry name" value="GPCR_2_GLP1_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017983">
        <property type="entry name" value="GPCR_2_secretin-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620:SF25">
        <property type="entry name" value="GLUCAGON-LIKE PEPTIDE 1 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45620">
        <property type="entry name" value="PDF RECEPTOR-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01353">
        <property type="entry name" value="GLUCAGNFAMLY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01355">
        <property type="entry name" value="GLUCAGNLIKER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00249">
        <property type="entry name" value="GPCRSECRETIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00008">
        <property type="entry name" value="HormR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111418">
        <property type="entry name" value="Hormone receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00649">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00650">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50227">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133518" description="Glucagon-like peptide 1 receptor" evidence="18">
        <location>
            <begin position="24"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="353"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 1" evidence="19">
        <location>
            <begin position="45"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="20">
        <location>
            <begin position="144"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
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            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023224"/>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00068346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="19">
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            <dbReference type="PROSITE" id="PS50227"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50261"/>
        </source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015740.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="463" mass="52693" checksum="C4E7D935DCD67527" modified="2022-01-19" version="1">MAGAPGPLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRRQCQRFLSEAPPPATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERSSPEEQLLSLYIIYTVGYALSFCALVVASAILLGFRHLRCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLALSVFSEQRVFRLYVSIGWGVPLLFVVPWGVVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATVSSSVYSATCQASCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FBT8</accession>
    <name>A0A8B7FBT8_MICMU</name>
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        <submittedName>
            <fullName evidence="12">Transforming growth factor alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TGFA</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005114">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03005115">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605622.1">
        <property type="nucleotide sequence ID" value="XM_012750168.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FBT8"/>
    <dbReference type="Ensembl" id="ENSMICT00000027694.2">
        <property type="protein sequence ID" value="ENSMICP00000017098.1"/>
        <property type="gene ID" value="ENSMICG00000030189.2"/>
    </dbReference>
    <dbReference type="CTD" id="7039"/>
    <dbReference type="GeneTree" id="ENSGT00940000160058"/>
    <dbReference type="OrthoDB" id="9946464at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005154">
        <property type="term" value="F:epidermal growth factor receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051781">
        <property type="term" value="P:positive regulation of cell division"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045840">
        <property type="term" value="P:positive regulation of mitotic nuclear division"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000182">
        <property type="entry name" value="Protransforming growth factor alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740:SF1">
        <property type="entry name" value="PROTRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10740">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00009">
        <property type="entry name" value="EGFTGF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="4" id="KW-0339">Growth factor</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0497">Mitogen</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133559" evidence="10">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="42"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="72"/>
            <end position="81"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023246"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063435"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017098.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="159" mass="17016" checksum="951F34584E4A7E75" modified="2022-01-19" version="1">MVTSAGQLVLLALGIVLAMCQALENSTSSQSDPPMAAAVVSHFNDCPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAVLIIACVLIHCCQVRKHCEWCRALVCRHEKPSALLKGRTTCCHSETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FCA1</accession>
    <name>A0A8B7FCA1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Palmitoyltransferase</fullName>
            <ecNumber evidence="16">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">ZDHHC17</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="16"/>
    <dbReference type="EMBL" id="ABDC03009389">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605802.1">
        <property type="nucleotide sequence ID" value="XM_012750348.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FCA1"/>
    <dbReference type="SMR" id="A0A8B7FCA1"/>
    <dbReference type="Ensembl" id="ENSMICT00000026337.2">
        <property type="protein sequence ID" value="ENSMICP00000033020.1"/>
        <property type="gene ID" value="ENSMICG00000033453.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105863373"/>
    <dbReference type="CTD" id="23390"/>
    <dbReference type="GeneTree" id="ENSGT00530000063074"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140240">
        <property type="term" value="C:perforant pathway to dendrate granule cell synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0150051">
        <property type="term" value="C:postsynaptic Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007409">
        <property type="term" value="P:axonogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098987">
        <property type="term" value="P:regulation of modification of synapse structure, modulating synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051386">
        <property type="term" value="P:regulation of neurotrophin TRK receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043067">
        <property type="term" value="P:regulation of programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000035">
        <property type="entry name" value="Palmitoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF18">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="539"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="17">
        <location>
            <begin position="438"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="632" mass="72640" checksum="3FD5FD592F2C617F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FIX1</accession>
    <name>A0A8B7FIX1_MICMU</name>
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        <submittedName>
            <fullName evidence="13">Solute carrier family 16 member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">SLC16A10</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)</text>
            <dbReference type="Rhea" id="RHEA:71811"/>
            <dbReference type="ChEBI" id="CHEBI:533015"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:71812"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="8">
            <dbReference type="Rhea" id="RHEA:71813"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-thyroxine(out) = L-thyroxine(in)</text>
            <dbReference type="Rhea" id="RHEA:71819"/>
            <dbReference type="ChEBI" id="CHEBI:58448"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:71820"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:71821"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008282">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012608528.1">
        <property type="nucleotide sequence ID" value="XM_012753074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FIX1"/>
    <dbReference type="Ensembl" id="ENSMICT00000029717.2">
        <property type="protein sequence ID" value="ENSMICP00000025842.2"/>
        <property type="gene ID" value="ENSMICG00000030833.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105864901"/>
    <dbReference type="KEGG" id="mmur:105864901"/>
    <dbReference type="CTD" id="117247"/>
    <dbReference type="GeneTree" id="ENSGT00940000157966"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015192">
        <property type="term" value="F:L-phenylalanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015196">
        <property type="term" value="F:L-tryptophan transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015349">
        <property type="term" value="F:thyroid hormone transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006590">
        <property type="term" value="P:thyroid hormone generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070460">
        <property type="term" value="P:thyroid-stimulating hormone secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000330">
        <property type="entry name" value="monocarboxylate transporter 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000156">
        <property type="entry name" value="monocarboxylate transporter 8 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF119">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="289"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025842.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="517" mass="55769" checksum="B4007AC43E4BC361" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FPP4</accession>
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        <submittedName>
            <fullName evidence="2">Chromosome 20 open reading frame 173</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">C20orf173</name>
        <name evidence="2" type="synonym">C18H20orf173</name>
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    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
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        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03021606">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7FPP4"/>
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        <property type="gene ID" value="ENSMICG00000004178.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000049503"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003836">
        <property type="term" value="F:beta-galactoside (CMP) alpha-2,3-sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097503">
        <property type="term" value="P:sialylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Beta-gal_alpha2-3_sialyltrans"/>
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        <property type="entry name" value="GT29-like_sf"/>
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        <property type="entry name" value="ALPHA-2,3-SIALYLTRANSFERASE ST3GAL I ISOFORM X1"/>
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    </dbReference>
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        <property type="entry name" value="RIKEN CDNA 6430550D23 GENE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133650" evidence="1">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003803.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="202" mass="22732" checksum="EF6D7BE5D52BD46C" modified="2022-01-19" version="1">MKRWQIFVLWVLWVLILWLMATCLDLTPAESALQEERTYLVPWSCTCRWFKPKKCGCPSETLNCSSCHHAAGGCHWFDAYCENTKGYLMRKKESMASDAVLWWLGMNSGSQLGKVWTTLFKVILRPSASHFDFSCGACVMLGSPQILPGSGLSSNMDRNRVAFRNASDQGSWRQLLLLLLLPDLARTSDALGDEISEDGPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FS41</accession>
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        <recommendedName>
            <fullName evidence="6">S1 RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="10" type="primary">SRBD1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012611420.1">
        <property type="nucleotide sequence ID" value="XM_012755966.3"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000040009.2">
        <property type="protein sequence ID" value="ENSMICP00000019450.2"/>
        <property type="gene ID" value="ENSMICG00000007835.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105866559"/>
    <dbReference type="KEGG" id="mmur:105866559"/>
    <dbReference type="CTD" id="55133"/>
    <dbReference type="GeneTree" id="ENSGT00510000047850"/>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000001">
        <property type="entry name" value="RNA-binding transcriptional accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1 RNA-binding domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tex RuvX-like domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="Ribos_protein_bS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
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        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
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        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
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        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="30S RIBOSOMAL PROTEIN S1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF10">
        <property type="entry name" value="S1 RNA-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF22706">
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YqgFc"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
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    </dbReference>
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    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
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        <location>
            <begin position="919"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019450.2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="995" mass="111777" checksum="F370D15EC617A44A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FZ60</accession>
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        <submittedName>
            <fullName evidence="6">Canopy FGF signaling regulator 4</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="primary">CNPY4</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
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        <lineage>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the canopy family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021066">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000004001.3">
        <property type="protein sequence ID" value="ENSMICP00000003645.3"/>
        <property type="gene ID" value="ENSMICG00000004002.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105868310"/>
    <dbReference type="KEGG" id="mmur:105868310"/>
    <dbReference type="CTD" id="245812"/>
    <dbReference type="GeneTree" id="ENSGT00390000014072"/>
    <dbReference type="OrthoDB" id="6020060at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903078">
        <property type="term" value="P:positive regulation of protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021852">
        <property type="entry name" value="DUF3456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382">
        <property type="entry name" value="CTG4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15382:SF3">
        <property type="entry name" value="PROTEIN CANOPY HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11938">
        <property type="entry name" value="DUF3456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133708" evidence="4">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3456" evidence="5">
        <location>
            <begin position="35"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11938"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003645.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="242" mass="27675" checksum="E3D514DADBCD40CC" modified="2022-01-19" version="1">MGPVRLGLLLFILAVYGAWAETPKDDDDTERLPSKCEVCKLLSTELQEELSRTGRSREVLELGQVLDTGKRKRHVPYSVSETRLEEALENLCERILDYSVHAERKGSLRYAKGQSQTMATLKGLVQKGVKVDLGIPLELWDEPSVEVTFLKKQCETMLEEFEDVVGDWYFHHQEQPLQHFLCEGHVLPAVETACLQETWTGKEKITDGQEKTKEEEEEEEEEEEGEKLTKTPGHPKHDPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G517</accession>
    <name>A0A8B7G517_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 227</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF227</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026725">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616734.1">
        <property type="nucleotide sequence ID" value="XM_012761280.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616735.1">
        <property type="nucleotide sequence ID" value="XM_012761281.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G517"/>
    <dbReference type="Ensembl" id="ENSMICT00000063707.1">
        <property type="protein sequence ID" value="ENSMICP00000044138.1"/>
        <property type="gene ID" value="ENSMICG00000042316.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105869475"/>
    <dbReference type="KEGG" id="mmur:105869475"/>
    <dbReference type="CTD" id="7770"/>
    <dbReference type="GeneTree" id="ENSGT00940000162819"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000274">
        <property type="entry name" value="zinc finger protein 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001158">
        <property type="entry name" value="zinc finger protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001534">
        <property type="entry name" value="zinc finger protein 227 isoform X1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000506">
        <property type="entry name" value="Zinc finger protein 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000623">
        <property type="entry name" value="Zinc finger protein 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000269">
        <property type="entry name" value="Zinc finger protein 287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000663">
        <property type="entry name" value="Zinc finger protein 45"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002090">
        <property type="entry name" value="Zinc finger protein 473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000384">
        <property type="entry name" value="Zinc finger protein 550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002357">
        <property type="entry name" value="Zinc finger protein 782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399:SF54">
        <property type="entry name" value="GASTRULA ZINC FINGER PROTEIN XLCGF26.1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24399">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="23"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="418"/>
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        </location>
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        <location>
            <begin position="446"/>
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        <location>
            <begin position="474"/>
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            <begin position="502"/>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="614"/>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="642"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="670"/>
            <end position="697"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="754"/>
            <end position="781"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="782"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067244"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="809" mass="93078" checksum="690E99741B3157CB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G7R2</accession>
    <name>A0A8B7G7R2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor A, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">TFAM</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Monomer; binds DNA as a monomer. Homodimer. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT. In this complex TFAM recruits POLRMT to the promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Upon metabolic stress, forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT. Interacts with TFB1M and TFB2M. Interacts with CLPX; this enhances DNA-binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03019235">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618285.2">
        <property type="nucleotide sequence ID" value="XM_012762831.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G7R2"/>
    <dbReference type="Ensembl" id="ENSMICT00000010257.3">
        <property type="protein sequence ID" value="ENSMICP00000009341.3"/>
        <property type="gene ID" value="ENSMICG00000010260.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105870281"/>
    <dbReference type="CTD" id="7019"/>
    <dbReference type="GeneTree" id="ENSGT00440000039001"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd21987">
        <property type="entry name" value="HMG-box_TFAM_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000043">
        <property type="entry name" value="Transcription factor A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000045">
        <property type="entry name" value="Transcription factor A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF36">
        <property type="entry name" value="TRANSCRIPTION FACTOR A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09011">
        <property type="entry name" value="HMG_box_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="15">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="50"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="14">
        <location>
            <begin position="155"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009341.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="246" mass="28886" checksum="779185CEFFC19C69" modified="2022-01-19" version="1">MAPLRSMWGVLSALGRSGAELCAGCGMRLRLPFSFVYIPKWFSSALASYPKKPLTSYLRFSKEQLPIYKARNPDAKTTELIKKIAEVWRDLPDSEKKIYEDAYRADWQAYKEEVNRIQEQLTPSQVLSLEKEIIQKRLKKKSLIKKRELTMLGKPKRPRSAYNIFVSESFQEAKDSSSQAKLKSINENWKNLSSSEKQVYIQLAKDDKIRYYNEMKSWEEQMMEVGRDDLIRRYVKEQAKDDTEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GBV9</accession>
    <name>A0A8B7GBV9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Sal-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">SALL1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Transcriptional repressor involved in organogenesis. Plays an essential role in ureteric bud invasion during kidney development.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">May associate with NuRD histone deacetylase complex (HDAC). Interacts with components of HDAC complex including HDAC1, HDAC2, RBBP4, RBPP7, MTA1 and MTA2. Interacts with CCNQ. Interacts with NSD2 (via PHD-type zinc fingers 1, 2 and 3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024407">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619887.1">
        <property type="nucleotide sequence ID" value="XM_012764433.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619888.1">
        <property type="nucleotide sequence ID" value="XM_012764434.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619889.1">
        <property type="nucleotide sequence ID" value="XM_012764435.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000043106.2">
        <property type="protein sequence ID" value="ENSMICP00000026021.1"/>
        <property type="gene ID" value="ENSMICG00000036486.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871205"/>
    <dbReference type="KEGG" id="mmur:105871205"/>
    <dbReference type="CTD" id="6299"/>
    <dbReference type="GeneTree" id="ENSGT00940000155938"/>
    <dbReference type="OrthoDB" id="8749569at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000792">
        <property type="term" value="C:heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008013">
        <property type="term" value="F:beta-catenin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 18" id="KW-0863">Zinc-finger</keyword>
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        <source>
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    <sequence length="1315" mass="139199" checksum="785092C1E46EEB21" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GU44</accession>
    <name>A0A8B7GU44_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">POC1 centriolar protein homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">WD repeat-containing protein 51A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">POC1A</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with POC1B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat POC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626949.1">
        <property type="nucleotide sequence ID" value="XM_012771495.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7GU44"/>
    <dbReference type="Ensembl" id="ENSMICT00000035278.2">
        <property type="protein sequence ID" value="ENSMICP00000019594.1"/>
        <property type="gene ID" value="ENSMICG00000002709.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875038"/>
    <dbReference type="CTD" id="25886"/>
    <dbReference type="GeneTree" id="ENSGT00940000157494"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:growth plate cartilage chondrocyte development"/>
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        <property type="term" value="P:positive regulation of centrosome duplication"/>
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        <property type="entry name" value="POC1 centriolar protein homolog A"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="WDR55/POC1"/>
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        <property type="entry name" value="POC1 CENTRIOLAR PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="15"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="57"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
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    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="183"/>
            <end position="224"/>
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    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004120"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004647"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
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        <source>
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    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019594.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="406" mass="44989" checksum="46D5FD29A786B23E" modified="2022-01-19" version="1">MAAPCLEDPSLERHFKGHRDAVTCVDFSLNMKQLASGSMDSCLMVWHMKPQSRAYRFMGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSLVTASDDKTVKVWSTHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKNSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNALSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDVDYGEVLKVQRPPATLAGTAGNLPAVDFPIPPGRGKSLESVQSQPPEPTSMPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H429</accession>
    <name>A0A8B7H429_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DDX18</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop. Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells. Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with NOL8; the interaction is RNA-dependent. Interacts with PRC2 complex components EZH2, SUZ2 and JARID2; these interactions prevent deposition of the repressive H3K27me3 mark onto rDNA in pluripotent cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="13"/>
    <dbReference type="EMBL" id="ABDC03011366">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631065.1">
        <property type="nucleotide sequence ID" value="XM_012775611.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H429"/>
    <dbReference type="Ensembl" id="ENSMICT00000070794.1">
        <property type="protein sequence ID" value="ENSMICP00000042389.1"/>
        <property type="gene ID" value="ENSMICG00000047072.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105877244"/>
    <dbReference type="KEGG" id="mmur:105877244"/>
    <dbReference type="CTD" id="8886"/>
    <dbReference type="GeneTree" id="ENSGT00680000100037"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="211"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="400"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="628"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="671" mass="75606" checksum="E0DDCE3920E7AFA8" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H4C3</accession>
    <name>A0A8B7H4C3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Zinc finger protein 569</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">ZNF569</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026965">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630289.1">
        <property type="nucleotide sequence ID" value="XM_012774835.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630290.1">
        <property type="nucleotide sequence ID" value="XM_012774836.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630292.1">
        <property type="nucleotide sequence ID" value="XM_012774838.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H4C3"/>
    <dbReference type="Ensembl" id="ENSMICT00000036660.2">
        <property type="protein sequence ID" value="ENSMICP00000037069.1"/>
        <property type="gene ID" value="ENSMICG00000038344.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105876858"/>
    <dbReference type="KEGG" id="mmur:105876858"/>
    <dbReference type="CTD" id="148266"/>
    <dbReference type="GeneTree" id="ENSGT00940000154650"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:004137">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000136">
        <property type="entry name" value="GLI family zinc finger 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000944">
        <property type="entry name" value="zinc finger protein 232 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002402">
        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000023">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002254">
        <property type="entry name" value="Zinc finger protein 540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000281">
        <property type="entry name" value="Zinc finger protein 558 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000149">
        <property type="entry name" value="Zinc finger protein 569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001558">
        <property type="entry name" value="Zinc finger protein 569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001270">
        <property type="entry name" value="zinc finger protein 583 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000176">
        <property type="entry name" value="zinc finger protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226">
        <property type="entry name" value="ZINC FINGER AND SCAN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23226:SF366">
        <property type="entry name" value="ZINC FINGER PROTEIN ZFP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="15">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="605"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="661"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="685" mass="79025" checksum="86EE27BCFC71C322" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HBC2</accession>
    <name>A0A8B7HBC2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Dpy-19 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">DPY19L2</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015720">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015721">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633011.1">
        <property type="nucleotide sequence ID" value="XM_012777557.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HBC2"/>
    <dbReference type="Ensembl" id="ENSMICT00000036231.2">
        <property type="protein sequence ID" value="ENSMICP00000034289.1"/>
        <property type="gene ID" value="ENSMICG00000028498.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878230"/>
    <dbReference type="KEGG" id="mmur:105878230"/>
    <dbReference type="CTD" id="283417"/>
    <dbReference type="GeneTree" id="ENSGT00530000063023"/>
    <dbReference type="OrthoDB" id="6019623at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20179">
        <property type="entry name" value="Dpy19L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018732">
        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488:SF6">
        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10034">
        <property type="entry name" value="Dpy19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="775" mass="89684" checksum="A5C1CB9FF6D91F79" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HF64</accession>
    <name>A0A8B7HF64_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-9kD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase 9 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">NDUFV3</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFV3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03033307">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033308">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033309">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03033310">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012634579.1">
        <property type="nucleotide sequence ID" value="XM_012779125.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HF64"/>
    <dbReference type="Ensembl" id="ENSMICT00000068528.1">
        <property type="protein sequence ID" value="ENSMICP00000040871.1"/>
        <property type="gene ID" value="ENSMICG00000046617.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105879121"/>
    <dbReference type="KEGG" id="mmur:105879121"/>
    <dbReference type="CTD" id="4731"/>
    <dbReference type="GeneTree" id="ENSGT00390000012196"/>
    <dbReference type="OrthoDB" id="6161911at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026193">
        <property type="entry name" value="NDUFV3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17117:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17117">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15880">
        <property type="entry name" value="NDUFV3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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            <fullName evidence="3">RNA polymerase III subunit E</fullName>
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        <name evidence="3" type="primary">POLR3E</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        </source>
    </evidence>
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            <fullName evidence="2">RD3 regulator of GUCY2D</fullName>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
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                <person name="Doddapaneni H."/>
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                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
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                <person name="Nguyen L."/>
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                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2" key="2">
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            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <authorList>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    <name>A0A8B7HJ48_MICMU</name>
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        <recommendedName>
            <fullName evidence="4">Putative monooxygenase p33MONOX</fullName>
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        <name evidence="10" type="primary">KIAA1191</name>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with NELFB, NOL12 and PRNP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the P33MONOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03028883">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028884">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028885">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028886">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028887">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03028888">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636984.2">
        <property type="nucleotide sequence ID" value="XM_012781530.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636985.2">
        <property type="nucleotide sequence ID" value="XM_012781531.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636986.2">
        <property type="nucleotide sequence ID" value="XM_012781532.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HJ48"/>
    <dbReference type="Ensembl" id="ENSMICT00000034982.2">
        <property type="protein sequence ID" value="ENSMICP00000033357.2"/>
        <property type="gene ID" value="ENSMICG00000037293.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105880468"/>
    <dbReference type="KEGG" id="mmur:105880468"/>
    <dbReference type="CTD" id="57179"/>
    <dbReference type="GeneTree" id="ENSGT00390000000537"/>
    <dbReference type="OrthoDB" id="8935954at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026759">
        <property type="entry name" value="P33MONOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28342">
        <property type="entry name" value="MONOOXYGENASE P33MONOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28342:SF1">
        <property type="entry name" value="MONOOXYGENASE P33MONOX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15302">
        <property type="entry name" value="P33MONOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033357.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="305" mass="33198" checksum="D199AD8EF43276FC" modified="2022-01-19" version="1">MASRQPEVPALEPSGPLGKMSLPIGICRRAFSYDDALEDPAPMTPPPSDMGSIPWKPVIPERKYQHLAQVEEGEASVSSLAMTLPSATDSVDKVPVVKAKATHVIMNSLVTKQTQESIQRFEQQAGLRDAGYTPHKGLTTEESKYLRVAEALHKLKLQSGEITKEEKQPASAQSTPSSTPHSSPKHRPRGWFTSGSSTALPGPNPGTMDSGSGDKDRNPSDKWSFFGTRPLQKYDSGSFATQAYRGAQKPSPMELIRAQATRMAEDPATFKPPKMDVPVMEGKTQPPRTHSLKPRDLNVLTPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HLE9</accession>
    <name>A0A8B7HLE9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Carbonyl reductase (NADPH)</fullName>
            <ecNumber evidence="7 9">1.1.1.184</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">CBR3</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a secondary alcohol + NADP(+) = a ketone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19257"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.184"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.184" evidence="7 9"/>
    <dbReference type="EMBL" id="ABDC03033153">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HLE9"/>
    <dbReference type="Ensembl" id="ENSMICT00000042425.2">
        <property type="protein sequence ID" value="ENSMICP00000017555.2"/>
        <property type="gene ID" value="ENSMICG00000002179.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881309"/>
    <dbReference type="KEGG" id="mmur:105881309"/>
    <dbReference type="GeneTree" id="ENSGT00940000162541"/>
    <dbReference type="OMA" id="MAGDYGS"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004090">
        <property type="term" value="F:carbonyl reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050890">
        <property type="term" value="P:cognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd05324">
        <property type="entry name" value="carb_red_PTCR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000164">
        <property type="entry name" value="Carbonyl reductase [NADPH] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045313">
        <property type="entry name" value="CBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963">
        <property type="entry name" value="CARBONYL REDUCTASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43963:SF3">
        <property type="entry name" value="CARBONYL REDUCTASE [NADPH] 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0521">NADP</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017555.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="277" mass="30751" checksum="68EB0C21AC7A6F22" modified="2022-01-19" version="1">MSSCSRVALVTGANKGIGFAIARDLCRQFSGDVVLTARDAARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRREYGGLNVLVNNAGIAFKIDDPTPFDIQAEMTMKTNFFATRNVCTELLPIMKPHGRVVNISSLQGLKALENCSEELQEKFRCETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSAYGVSKLGVTVLSRILARRLDEKRKADRILLNACCPGWVKTDMAGTYGSRTVEEGAETPVYLALLPPDATEPHGQLVRDKVVQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HQS8</accession>
    <name>A0A8B7HQS8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein arginine N-methyltransferase 9</fullName>
            <ecNumber evidence="2">2.1.1.320</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Protein arginine N-methyltransferase 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">PRMT9</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Found in a complex with PRMT9, SF3B2 and SF3B4. Interacts with SF3B2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03018656">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018657">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018658">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03018659">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639210.1">
        <property type="nucleotide sequence ID" value="XM_012783756.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HQS8"/>
    <dbReference type="Ensembl" id="ENSMICT00000030556.2">
        <property type="protein sequence ID" value="ENSMICP00000033014.1"/>
        <property type="gene ID" value="ENSMICG00000000584.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881836"/>
    <dbReference type="KEGG" id="mmur:105881836"/>
    <dbReference type="CTD" id="90826"/>
    <dbReference type="GeneTree" id="ENSGT00940000158472"/>
    <dbReference type="OrthoDB" id="5980806at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000138">
        <property type="entry name" value="Protein arginine methyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000006">
        <property type="entry name" value="Protein arginine methyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000078">
        <property type="entry name" value="Protein arginine methyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000384">
        <property type="entry name" value="Protein arginine methyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000011">
        <property type="entry name" value="Protein arginine N-methyltransferase 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF60">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 14" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="14">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="367"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="17">
        <location>
            <begin position="751"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="846" mass="94714" checksum="E2A3DCAE900C7F3C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HT45</accession>
    <name>A0A8B7HT45_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">RPL13</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035946">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640198.1">
        <property type="nucleotide sequence ID" value="XM_012784744.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HT45"/>
    <dbReference type="Ensembl" id="ENSMICT00000065704.1">
        <property type="protein sequence ID" value="ENSMICP00000042390.1"/>
        <property type="gene ID" value="ENSMICG00000043954.1"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105882403"/>
    <dbReference type="GeneTree" id="ENSGT00390000007818"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="211" mass="24245" checksum="4B26C9A7F43B5972" modified="2022-01-19" version="1">MAPSRNGMILKPHFHKGWQRRVATWFNQPARKIRRRKARQAKARRIAPRPASGPIRPIVRCPTVRYHTKVRAGRGFSLEELRVAGIHKKVARTIGISVDPRRRNKSTESLQANVQRLREYRSKLILFPRKPSAPKKGDSSGEELKLATQLTGPVMPIRNVYKKEKARVITEEEKNFKAFASLRMARANARLFGIRAKRAKEAAEQDVEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HUH2</accession>
    <name>A0A8B7HUH2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CLCN6</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:29567"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:29568"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Membrane</location>
            <topology evidence="20">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002382">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640786.1">
        <property type="nucleotide sequence ID" value="XM_012785332.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HUH2"/>
    <dbReference type="Ensembl" id="ENSMICT00000065702.1">
        <property type="protein sequence ID" value="ENSMICP00000046329.1"/>
        <property type="gene ID" value="ENSMICG00000003383.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882713"/>
    <dbReference type="CTD" id="1185"/>
    <dbReference type="GeneTree" id="ENSGT00940000159291"/>
    <dbReference type="OrthoDB" id="428525at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03685">
        <property type="entry name" value="ClC_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000010">
        <property type="entry name" value="Chloride voltage-gated channel 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051280">
        <property type="entry name" value="Cl-channel/antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002248">
        <property type="entry name" value="Cl_channel-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11689:SF158">
        <property type="entry name" value="H(+)_CL(-) EXCHANGE TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01117">
        <property type="entry name" value="CLCHANNEL6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 19" id="KW-0129">CBS domain</keyword>
    <keyword evidence="15 20" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 20" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 20" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="807"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00056509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00061575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="869" mass="97522" checksum="A2D7F9E72F49F982" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HY72</accession>
    <name>A0A8B7HY72_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Matrilin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">MATN3</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1. Interacts with COMP. Component of a complex containing at least CRELD2, MANF, MATN3 and PDIA4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011980">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643184.1">
        <property type="nucleotide sequence ID" value="XM_012787730.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HY72"/>
    <dbReference type="Ensembl" id="ENSMICT00000037831.2">
        <property type="protein sequence ID" value="ENSMICP00000039363.2"/>
        <property type="gene ID" value="ENSMICG00000032185.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105884040"/>
    <dbReference type="KEGG" id="mmur:105884040"/>
    <dbReference type="CTD" id="4148"/>
    <dbReference type="GeneTree" id="ENSGT00940000157581"/>
    <dbReference type="OrthoDB" id="6022609at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120216">
        <property type="term" value="C:matrilin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051216">
        <property type="term" value="P:cartilage development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000018">
        <property type="entry name" value="Matrilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.30:FF:000004">
        <property type="entry name" value="Matrilin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000126">
        <property type="entry name" value="Matrilin 3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050525">
        <property type="entry name" value="ECM_Assembly_Org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036337">
        <property type="entry name" value="Matrilin_CC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019466">
        <property type="entry name" value="Matrilin_CC_trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24020:SF12">
        <property type="entry name" value="MATRILIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14670">
        <property type="entry name" value="FXa_inhibition"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10393">
        <property type="entry name" value="Matrilin_ccoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00453">
        <property type="entry name" value="VWFADOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01279">
        <property type="entry name" value="Matrilin_ccoil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58002">
        <property type="entry name" value="Chicken cartilage matrix protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134188" description="Matrilin-3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="17">
        <location>
            <begin position="84"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="16">
        <location>
            <begin position="307"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00063495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039363.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="487" mass="52675" checksum="38D8F303CD83BA0A" modified="2022-01-19" version="1">MPRPAPTRHLPGLLLLLWPLLLLPPLAAPGPLARPGFRRLGTRGPGGSPGRSPAPAAPTRAPHSGAGQPGGARGAGVCKSRPLDLVFIIDSSRSVRPLEFTKVKTFVSQIIDTLDIGAADTRVAVVNYASTVKIEFHLQTYSDKQSLKQAVGRITPLSTGTMSGLAIQTAMDEAFTVEAGARGPTSNIPKVAIIVTDGRPQDQVTEVAARARASGIELYAVGVDRADMESLKMMASEPLDEHVFYVETYGVIEKLSSRFQETFCAVDPCVLGTHQCQHVCISDGDGRHHCECSQGYALNADKKTCSAIDKCALNTHGCEHVCVNDRTGSYHCECYEGYTLNEDRKTCSAQDRCALGTHGCQHLCVNDRNGSHHCECYEGYALNADKKTCTVRDKCTLGSHGCQHICVSDGAASYHCDCFPGYTLNEDKRTCSAIEEARRLVSTEDACGCEATLAFQDKVSSYLQRLNTKLDGILKKLQINEYGQIHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I7I3</accession>
    <name>A0A8B7I7I3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3'(2'),5'-bisphosphate nucleotidase 1</fullName>
            <ecNumber evidence="17">3.1.3.57</ecNumber>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">3'-phosphoadenosine 5'-phosphate phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Bisphosphate 3'-nucleotidase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Inositol-polyphosphate 1-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">BPNT1</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.57" evidence="17"/>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03029439">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029440">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029441">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646953.1">
        <property type="nucleotide sequence ID" value="XM_012791499.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I7I3"/>
    <dbReference type="Ensembl" id="ENSMICT00000044654.2">
        <property type="protein sequence ID" value="ENSMICP00000039951.1"/>
        <property type="gene ID" value="ENSMICG00000017745.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000059146.1">
        <property type="protein sequence ID" value="ENSMICP00000046614.1"/>
        <property type="gene ID" value="ENSMICG00000017745.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105886079"/>
    <dbReference type="CTD" id="10380"/>
    <dbReference type="GeneTree" id="ENSGT00940000157359"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01640">
        <property type="entry name" value="IPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000011">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000006">
        <property type="entry name" value="Bisphosphate nucleotidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
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        <property type="entry name" value="Inositol_monoP_metal-BS"/>
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    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
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    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0452">Lithium</keyword>
    <keyword evidence="8 20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
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        <location>
            <position position="120"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00044554"/>
        </source>
    </evidence>
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            <dbReference type="PIRSR" id="PIRSR600760-2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="308" mass="33498" checksum="E05A2A3D3CC3D75C" modified="2022-01-19" version="1">MASSHTVLMRLVASAYSIAQKAGVIVRRVIAEGDLGIVEKTCATDLQTKADRLVQMSICSSLARKFPKLTIIGEEDLPPEEVDQELIEDGQWEEILKQPCPSQYSNIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGIINQPYYNYQAGPDAVLGRTIWGILGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVTAMNPDDVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNALQYNKEVKHMNSAGVLATLRNYDYYASRVPESVKKALVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I896</accession>
    <name>A0A8B7I896_MICMU</name>
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        <submittedName>
            <fullName evidence="2">Cancer/testis antigen 83</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="primary">CT83</name>
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    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03034398">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646470.1">
        <property type="nucleotide sequence ID" value="XM_012791016.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I896"/>
    <dbReference type="Ensembl" id="ENSMICT00000052651.2">
        <property type="protein sequence ID" value="ENSMICP00000028120.1"/>
        <property type="gene ID" value="ENSMICG00000029868.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885783"/>
    <dbReference type="KEGG" id="mmur:105885783"/>
    <dbReference type="CTD" id="203413"/>
    <dbReference type="GeneTree" id="ENSGT00390000018873"/>
    <dbReference type="OrthoDB" id="9529309at2759"/>
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        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027940">
        <property type="entry name" value="KKLCAg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38650">
        <property type="entry name" value="KITA-KYUSHU LUNG CANCER ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38650:SF1">
        <property type="entry name" value="KITA-KYUSHU LUNG CANCER ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15204">
        <property type="entry name" value="KKLCAg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="125" mass="13980" checksum="86B05C9A1A587100" modified="2022-01-19" version="1">METLLILPSCVLIAFLIIFWKYGFERNIGEISNSTSLALVRTSSTGSTKSNTDKSLSVNNLSRDILNNFPHSIAMQKRILVNLRIVEYKLAELEHFLVTRGLNGALVNRKSTEKLTRCNDSGGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WNM6</accession>
    <name>A0A8B7WNM6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein subunit beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNB1</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002140">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631915.1">
        <property type="nucleotide sequence ID" value="XM_012776461.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136893.1">
        <property type="nucleotide sequence ID" value="XM_020281304.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136894.1">
        <property type="nucleotide sequence ID" value="XM_020281305.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136899.1">
        <property type="nucleotide sequence ID" value="XM_020281310.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136900.1">
        <property type="nucleotide sequence ID" value="XM_020281311.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136905.1">
        <property type="nucleotide sequence ID" value="XM_020281316.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020136907.1">
        <property type="nucleotide sequence ID" value="XM_020281318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WNM6"/>
    <dbReference type="Ensembl" id="ENSMICT00000037353.2">
        <property type="protein sequence ID" value="ENSMICP00000023098.1"/>
        <property type="gene ID" value="ENSMICG00000033912.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105877661"/>
    <dbReference type="CTD" id="2782"/>
    <dbReference type="GeneTree" id="ENSGT01000000214413"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001750">
        <property type="term" value="C:photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060041">
        <property type="term" value="P:retina development in camera-type eye"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050909">
        <property type="term" value="P:sensory perception of taste"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="340" mass="37347" checksum="733C533362687E99" modified="2022-01-19" version="1">MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDARLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7X7U3</accession>
    <name>A0A8B7X7U3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TBC1 domain family member 30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TBC1D30</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009750">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020143118.1">
        <property type="nucleotide sequence ID" value="XM_020287529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7X7U3"/>
    <dbReference type="Ensembl" id="ENSMICT00000069215.1">
        <property type="protein sequence ID" value="ENSMICP00000047539.1"/>
        <property type="gene ID" value="ENSMICG00000027290.2"/>
    </dbReference>
    <dbReference type="CTD" id="23329"/>
    <dbReference type="GeneTree" id="ENSGT00940000159226"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902018">
        <property type="term" value="P:negative regulation of cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000011">
        <property type="entry name" value="TBC1 domain family member 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000009">
        <property type="entry name" value="TBC1 domain family member 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032738">
        <property type="entry name" value="Tbc1d30_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13399">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN TRAP , GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15733">
        <property type="entry name" value="DUF4682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="4">
        <location>
            <begin position="124"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="719"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="719"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00067508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="813" mass="90427" checksum="B586F236D5251F10" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UKI2</accession>
    <name>A0A8C5UKI2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myocyte enhancer factor 2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MEF2B</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03027894">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027895">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UKI2"/>
    <dbReference type="Ensembl" id="ENSMICT00000000436.3">
        <property type="protein sequence ID" value="ENSMICP00000000398.3"/>
        <property type="gene ID" value="ENSMICG00000000439.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160699"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030054">
        <property type="term" value="C:cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000398.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UKR2</accession>
    <name>A0A8C5UKR2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">GPX3</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 glutathione + H2O2 = glutathione disulfide + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16833"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="EC" id="1.11.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03027509">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UKR2"/>
    <dbReference type="Ensembl" id="ENSMICT00000000659.3">
        <property type="protein sequence ID" value="ENSMICP00000000592.3"/>
        <property type="gene ID" value="ENSMICG00000000660.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161754"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 23"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008430">
        <property type="term" value="F:selenium binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000112">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF32">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034691992" description="Glutathione peroxidase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000592.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="222" mass="24843" checksum="3CBDE75B814FCB8D" modified="2022-01-19" version="1">MARLLRASCLLSLLLAGFVPPGRGQEKSKTDCHGGVSGTIYEYGALTIDGDEYIPFKQYAGKYVLFVNVASFGLTGQYVELNALQEELAPFGLVILGFPCNQFGKQEPGDNSEILPTIKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGSPGRLFWEPMKIHDIRWNFEKFLVGPDGIPVMRWHHRTTISNVKIDILSYMRRQAAKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UPM5</accession>
    <name>A0A8C5UPM5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="23">Potassium voltage-gated channel subfamily Q member 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="23" type="primary">KCNQ3</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>Cs(+)(in) = Cs(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78555"/>
            <dbReference type="ChEBI" id="CHEBI:49547"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Rb(+)(in) = Rb(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:78547"/>
            <dbReference type="ChEBI" id="CHEBI:49847"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03013447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013448">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012640872.1">
        <property type="nucleotide sequence ID" value="XM_012785418.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UPM5"/>
    <dbReference type="Ensembl" id="ENSMICT00000003614.3">
        <property type="protein sequence ID" value="ENSMICP00000003290.2"/>
        <property type="gene ID" value="ENSMICG00000003612.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105882764"/>
    <dbReference type="KEGG" id="mmur:105882764"/>
    <dbReference type="CTD" id="3786"/>
    <dbReference type="GeneTree" id="ENSGT00940000159760"/>
    <dbReference type="OrthoDB" id="8879391at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043194">
        <property type="term" value="C:axon initial segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033268">
        <property type="term" value="C:node of Ranvier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008076">
        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099610">
        <property type="term" value="P:action potential initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097314">
        <property type="term" value="P:apoptosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098976">
        <property type="term" value="P:excitatory chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098977">
        <property type="term" value="P:inhibitory chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060081">
        <property type="term" value="P:membrane hyperpolarization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051882">
        <property type="term" value="P:mitochondrial depolarization"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021675">
        <property type="term" value="P:nerve development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051402">
        <property type="term" value="P:neuron apoptotic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019228">
        <property type="term" value="P:neuronal action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036343">
        <property type="term" value="P:psychomotor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099611">
        <property type="term" value="P:regulation of action potential firing threshold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010996">
        <property type="term" value="P:response to auditory stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903701">
        <property type="term" value="P:substantia propria of cornea development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000017">
        <property type="entry name" value="potassium voltage-gated channel subfamily KQT member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000016">
        <property type="entry name" value="Putative potassium voltage-gated channel subfamily KQT member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020969">
        <property type="entry name" value="Ankyrin-G_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003937">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003948">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013821">
        <property type="entry name" value="K_chnl_volt-dep_KCNQ_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735:SF11">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47735">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03520">
        <property type="entry name" value="KCNQ_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11956">
        <property type="entry name" value="KCNQC3-Ank-G_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01462">
        <property type="entry name" value="KCNQ3CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01459">
        <property type="entry name" value="KCNQCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0630">Potassium</keyword>
    <keyword evidence="7" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="21">
        <location>
            <begin position="124"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel voltage dependent KCNQ C-terminal" evidence="22">
        <location>
            <begin position="446"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="573"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="710"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="761"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="842"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003290.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="871" mass="96562" checksum="77F4470BC7BD2654" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UPW2</accession>
    <name>A0A8C5UPW2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfotransferase</fullName>
            <ecNumber evidence="8">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">HS3ST4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="8"/>
    <dbReference type="EMBL" id="ABDC03021007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021008">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635581.1">
        <property type="nucleotide sequence ID" value="XM_012780127.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UPW2"/>
    <dbReference type="Ensembl" id="ENSMICT00000001584.3">
        <property type="protein sequence ID" value="ENSMICP00000001440.2"/>
        <property type="gene ID" value="ENSMICG00000001588.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879702"/>
    <dbReference type="KEGG" id="mmur:105879702"/>
    <dbReference type="CTD" id="9951"/>
    <dbReference type="GeneTree" id="ENSGT00940000161466"/>
    <dbReference type="OrthoDB" id="411451at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008467">
        <property type="term" value="F:[heparan sulfate]-glucosamine 3-sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015012">
        <property type="term" value="P:heparan sulfate proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001224">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002590">
        <property type="entry name" value="Sulfotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037359">
        <property type="entry name" value="NST/OST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605:SF11">
        <property type="entry name" value="HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10605">
        <property type="entry name" value="HEPARAN SULFATE SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="10">
        <location>
            <begin position="198"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="For sulfotransferase activity" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="413"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR637359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001440.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="456" mass="49904" checksum="E02B258FEC6F96E5" modified="2022-01-19" version="1">MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQEPSVTAAEPPPSPPPPSLPPLPVRLGAPSQPPAPPPLDNGSRGEPPEPPDQPAAPGADGWGLASGGGGARDAWLRTPLAPSEMITAQSALLEREAQESSTTDEELAGRRAANGSIERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNMMFYQMTGQDFQWEQEEGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQW5</accession>
    <name>A0A8C5UQW5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Tripartite motif containing 66</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">TRIM66</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03006407">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UQW5"/>
    <dbReference type="Ensembl" id="ENSMICT00000002291.3">
        <property type="protein sequence ID" value="ENSMICP00000002091.3"/>
        <property type="gene ID" value="ENSMICG00000002287.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159240"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010369">
        <property type="term" value="C:chromocenter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
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                <person name="Yoder A."/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UR45</accession>
    <name>A0A8C5UR45_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein TEL2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TELO2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020790">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020791">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03020792">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UR45"/>
    <dbReference type="Ensembl" id="ENSMICT00000000220.3">
        <property type="protein sequence ID" value="ENSMICP00000000199.3"/>
        <property type="gene ID" value="ENSMICG00000000220.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000006698"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000001">
        <property type="entry name" value="Telomere length regulation protein TEL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057348">
        <property type="entry name" value="TELO2_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25320">
        <property type="entry name" value="TELO2_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TELO2 ARM repeat" evidence="7">
        <location>
            <begin position="325"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="6">
        <location>
            <begin position="516"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000199.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="831" mass="90831" checksum="7DA7BC1E85A687D1" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5US62</accession>
    <name>A0A8C5US62_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4E nuclear import factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">EIF4ENIF1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024661">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5US62"/>
    <dbReference type="Ensembl" id="ENSMICT00000005482.3">
        <property type="protein sequence ID" value="ENSMICP00000004996.3"/>
        <property type="gene ID" value="ENSMICG00000005470.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012071"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035278">
        <property type="term" value="P:miRNA-mediated gene silencing by inhibition of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106289">
        <property type="term" value="P:negative regulation of deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030182">
        <property type="term" value="P:neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019827">
        <property type="term" value="P:stem cell population maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018862">
        <property type="entry name" value="eIF4E-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12269:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10477">
        <property type="entry name" value="EIF4E-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="696"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="896"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004996.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="974" mass="107316" checksum="E426295B53C60D30" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UU29</accession>
    <name>A0A8C5UU29_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PSMB2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001646">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001647">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001648">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620698.1">
        <property type="nucleotide sequence ID" value="XM_012765244.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UU29"/>
    <dbReference type="Ensembl" id="ENSMICT00000006455.3">
        <property type="protein sequence ID" value="ENSMICP00000005895.2"/>
        <property type="gene ID" value="ENSMICG00000006460.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871755"/>
    <dbReference type="KEGG" id="mmur:105871755"/>
    <dbReference type="CTD" id="5690"/>
    <dbReference type="GeneTree" id="ENSGT00640000091536"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005895.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="201" mass="22835" checksum="221930C66C7C039F" modified="2022-01-19" version="1">MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPNISREKAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLENISFPKQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UVV2</accession>
    <name>A0A8C5UVV2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lck interacting transmembrane adaptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">LIME1</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03022059">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVV2"/>
    <dbReference type="Ensembl" id="ENSMICT00000008849.3">
        <property type="protein sequence ID" value="ENSMICP00000008057.3"/>
        <property type="gene ID" value="ENSMICG00000008850.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00510000050080"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019815">
        <property type="term" value="C:B cell receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050853">
        <property type="term" value="P:B cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043122">
        <property type="term" value="P:regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901222">
        <property type="term" value="P:regulation of non-canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051279">
        <property type="term" value="P:regulation of release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050852">
        <property type="term" value="P:T cell receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026072">
        <property type="entry name" value="Lime1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47740:SF1">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47740">
        <property type="entry name" value="LCK-INTERACTING TRANSMEMBRANE ADAPTER 1, LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15332">
        <property type="entry name" value="LIME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034088495" evidence="1">
        <location>
            <begin position="31"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008057.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="297" mass="31416" checksum="F6A1D02BCFEA6F3E" modified="2022-01-19" version="1">MGLQVPSAPPALWVLGCCALLLWLWALCTANHPCPHLPPWPDNALAPRKRARRPWAGLQGSMLPAEAVSACLPRGQGGLGSLSKSDTRLHELHSGPQGGRAQRPVSMDLLRPHWPEMSRALPRLQAATSAFPHRELPQGPPAASPAMGPMATYSNVGLAAFPRVGLAASPVVAEYACVQKLKGTEQGSRKQQGRAKESPAAQVDILYSRVCKPKRRDPGPTTAPLDLEGRGAIPALGGDSAYEALPLRGLGVDSGPLENVYESIQEMGAHASDISWTPGHPVSTCLSPGRGWKPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UWQ8</accession>
    <name>A0A8C5UWQ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">GRIN2C</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18 26">Postsynaptic cell membrane</location>
            <topology evidence="18 26">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019893">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UWQ8"/>
    <dbReference type="Ensembl" id="ENSMICT00000010577.3">
        <property type="protein sequence ID" value="ENSMICP00000009633.3"/>
        <property type="gene ID" value="ENSMICG00000010565.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156964"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017146">
        <property type="term" value="C:NMDA selective glutamate receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004972">
        <property type="term" value="F:NMDA glutamate receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904315">
        <property type="term" value="F:transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097553">
        <property type="term" value="P:calcium ion transmembrane import into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033058">
        <property type="term" value="P:directional locomotion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060079">
        <property type="term" value="P:excitatory postsynaptic potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042177">
        <property type="term" value="P:negative regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050885">
        <property type="term" value="P:neuromuscular process controlling balance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903539">
        <property type="term" value="P:protein localization to postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048167">
        <property type="term" value="P:regulation of synaptic plasticity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06378">
        <property type="entry name" value="PBP1_iGluR_NMDA_NR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13718">
        <property type="entry name" value="PBP2_iGluR_NMDA_Nr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000026">
        <property type="entry name" value="Glutamate ionotropic receptor NMDA type subunit 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000020">
        <property type="entry name" value="Glutamate receptor ionotropic, NMDA 2B, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000007">
        <property type="entry name" value="Putative glutamate receptor ionotropic NMDA 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001508">
        <property type="entry name" value="Iono_Glu_rcpt_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018884">
        <property type="entry name" value="NMDAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10565">
        <property type="entry name" value="NMDAR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00177">
        <property type="entry name" value="NMDARECEPTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00918">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 26" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17 26" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10 26" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16 26" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15 26" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="13 26" id="KW-0675">Receptor</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 26" id="KW-0732">Signal</keyword>
    <keyword evidence="9 26" id="KW-0770">Synapse</keyword>
    <keyword evidence="4 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 26" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="26">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034693995" description="Glutamate receptor" evidence="26">
        <location>
            <begin position="20"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="626"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="815"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="28">
        <location>
            <begin position="439"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor L-glutamate and glycine-binding" evidence="29">
        <location>
            <begin position="447"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="27">
        <location>
            <begin position="921"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="27">
        <location>
            <begin position="928"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="24">
        <location>
            <position position="485"/>
        </location>
    </feature>
    <feature type="site" description="Crucial to convey clamshell closure to channel opening" evidence="24">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with the cone snail toxin Con-ikot-ikot" evidence="24">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="25">
        <location>
            <begin position="742"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00034104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00060923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR601508-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU367118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="SMART" id="SM00918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009633.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1237" mass="134617" checksum="C081437158BEC604" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXR9</accession>
    <name>A0A8C5UXR9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03035992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035993">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXR9"/>
    <dbReference type="Ensembl" id="ENSMICT00000010757.3">
        <property type="protein sequence ID" value="ENSMICP00000009804.3"/>
        <property type="gene ID" value="ENSMICG00000010756.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063666"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033182">
        <property type="entry name" value="MIC26/MIC27_animal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14564">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC26 / MIC27 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009804.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="198" mass="22232" checksum="639152B44A54D8A3" modified="2022-01-19" version="1">MFKVIQRSVGPASLSLLTLKVYAAPKKDSPPPYPMKIDELSLYSVPGGQSKYVEEPRTQLEERISQLRHYCEPYTRWCQETYSQTKPKIQTLIQCGLDSYEYLQNAPPGFFPRLGVIGFAGLVGLLLARGSKVKKLVYPPGFMGLAASIYYPQQAITFVQVSGEKLYDWGLRGYIVVEDLWKGSFQKPGNVKNSPGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXW0</accession>
    <name>A0A8C5UXW0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPATA31 subfamily G member 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">SPATA31G1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03014777">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXW0"/>
    <dbReference type="Ensembl" id="ENSMICT00000005461.3">
        <property type="protein sequence ID" value="ENSMICP00000004978.3"/>
        <property type="gene ID" value="ENSMICG00000005469.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000748"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039509">
        <property type="entry name" value="SPATA31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026677">
        <property type="entry name" value="Spata31g1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21777">
        <property type="entry name" value="RCG55159-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21777:SF0">
        <property type="entry name" value="RCG55159-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14650">
        <property type="entry name" value="FAM75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPATA31" evidence="2">
        <location>
            <begin position="110"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004978.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109098" checksum="8C4CA0495D0E00A0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZL5</accession>
    <name>A0A8C5UZL5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">USP10</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta (IL1B)-mediated NF-kappa-B activation by promoting IKBKG or TRAF6 deubiquitination. Interacts with IKBKG; this interaction increases in response to DNA damage. Interacts with TANK; this interaction increases in response to DNA damage. Interacts with TRAF6; this interaction increases in response to DNA damage. Interacts with ZC3H12A; this interaction increases in response to DNA damage. Interacts with G3BP1 (via NTF2 domain) and G3BP2 (via NTF2 domain); inhibiting stress granule formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family. USP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="15"/>
    <dbReference type="EMBL" id="ABDC03023436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZL5"/>
    <dbReference type="Ensembl" id="ENSMICT00000012613.3">
        <property type="protein sequence ID" value="ENSMICP00000011484.2"/>
        <property type="gene ID" value="ENSMICG00000028886.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074994"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030330">
        <property type="term" value="P:DNA damage response, signal transduction by p53 class mediator"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000015">
        <property type="entry name" value="Ubiquitin specific peptidase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF687">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="419"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="141"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="199"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="571"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011484.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="802" mass="87978" checksum="E3FF850E61F75DE7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V1C5</accession>
    <name>A0A8C5V1C5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Arachidonate 12-lipoxygenase, 12R type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ALOX12B</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="10">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020547">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631177.1">
        <property type="nucleotide sequence ID" value="XM_012775723.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V1C5"/>
    <dbReference type="Ensembl" id="ENSMICT00000013668.3">
        <property type="protein sequence ID" value="ENSMICP00000012470.2"/>
        <property type="gene ID" value="ENSMICG00000013664.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877312"/>
    <dbReference type="KEGG" id="mmur:105877312"/>
    <dbReference type="CTD" id="242"/>
    <dbReference type="GeneTree" id="ENSGT00940000162032"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004052">
        <property type="term" value="F:arachidonate 12(S)-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047677">
        <property type="term" value="F:arachidonate 8(R)-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990136">
        <property type="term" value="F:linoleate 9S-lipoxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061436">
        <property type="term" value="P:establishment of skin barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043651">
        <property type="term" value="P:linoleic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034440">
        <property type="term" value="P:lipid oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019372">
        <property type="term" value="P:lipoxygenase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070257">
        <property type="term" value="P:positive regulation of mucus secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd01753">
        <property type="entry name" value="PLAT_LOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.60:FF:000001">
        <property type="entry name" value="arachidonate 12-lipoxygenase, 12R-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.245.10:FF:000001">
        <property type="entry name" value="Arachidonate 5-lipoxygenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.60.20:FF:000002">
        <property type="entry name" value="Arachidonate 5-lipoxygenase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.245.10">
        <property type="entry name" value="Lipoxygenase-1, Domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000907">
        <property type="entry name" value="LipOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013819">
        <property type="entry name" value="LipOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036226">
        <property type="entry name" value="LipOase_C_sf"/>
    </dbReference>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
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    <keyword evidence="5 14" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7 10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 10 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="15">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
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    <feature type="domain" description="Lipoxygenase" evidence="16">
        <location>
            <begin position="119"/>
            <end position="701"/>
        </location>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="398"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="403"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        <location>
            <position position="578"/>
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        <ligand>
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            <position position="104"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
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                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
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            <begin position="20"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="90" mass="9759" checksum="82EA210C39318402" modified="2022-01-19" version="1">MASSRLSLVVLLLPAQHWSHDPQNALRTPGEILGTAAGSPAQTACSLPSDTLTSLKDRVPWEGRTMTQWWFKPLAGRGWRRAPAPGDGKV</sequence>
</entry>
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            <fullName evidence="2">Prefoldin subunit 5</fullName>
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        <name evidence="2" type="primary">PFDN5</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
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                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Prefoldin"/>
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        <property type="entry name" value="Prefoldin_subunit_alpha"/>
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        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
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        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
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    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013009.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="12409" checksum="899AFF4731BC00D7" modified="2022-01-19" version="1">MAQSINITELNLPQLEMLKNQLDQMYVPGKLHDVEHVLIDVGTGYYVEKTAEDAKDFFKRKIDFLTKQMEKIQPALQEKHAMKQAVMEMMSQKIQQLTALGAAQTTAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2C4</accession>
    <name>A0A8C5V2C4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">LOC105870766</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MHC class I family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023263">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023265">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2C4"/>
    <dbReference type="Ensembl" id="ENSMICT00000009082.3">
        <property type="protein sequence ID" value="ENSMICP00000008270.3"/>
        <property type="gene ID" value="ENSMICG00000047281.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01120000271826"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042612">
        <property type="term" value="C:MHC class I protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030670">
        <property type="term" value="C:phagocytic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042605">
        <property type="term" value="F:peptide antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002486">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002476">
        <property type="term" value="P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07698">
        <property type="entry name" value="IgC1_MHC_I_alpha3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000014">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000001">
        <property type="entry name" value="H-2 class I histocompatibility antigen, alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001039">
        <property type="entry name" value="MHC_I_a_a1/a2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF270">
        <property type="entry name" value="HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00129">
        <property type="entry name" value="MHC_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01638">
        <property type="entry name" value="MHCCLASSI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0490">MHC I</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="12">
        <location>
            <begin position="209"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008270.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="393" mass="43805" checksum="1EAE85C2D04FBC11" modified="2022-01-19" version="1">MAVPAPGAGAAREAGRGLSRSPPPGSHSLRYFASAVSRPGRGEPRYISVGYVDDTQFVRFDSDAESPRVEPRAPWVEREGPEYWDRETRVANGHAQTFRVNLRTALRYYNQSDGGSHTFQRMQGCILGPDGRLLRGYLQFAYDGADYLALNEDLRSWTAADTAAQISKRKWESAGEAEHRRAYLEGLCVDSLRRYLEHGKDTLLRADPPRTHVTHHPSSEREATMRCWALGFYPGEITLTWQRDGQDLTQDMEFVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPEPLTLRWEPPSQPSIPMVGIVAGLVVLGAVLIGAVVAAVMWRKKSSGRKGWGRRWCFLVPLGVSRPGRSVPCLTQGPCLLTLALLERTWNVQNKSITLMIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V2X8</accession>
    <name>A0A8C5V2X8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">STAGA complex 65 subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">SPTF-associated factor 65 gamma</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Suppressor of Ty 7-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">SUPT7L</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, SUPT7L, GCN5L2, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12 and TAF9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03011903">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V2X8"/>
    <dbReference type="Ensembl" id="ENSMICT00000014948.3">
        <property type="protein sequence ID" value="ENSMICP00000013629.2"/>
        <property type="gene ID" value="ENSMICG00000014961.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000005572"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051457">
        <property type="term" value="P:maintenance of protein location in nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd06847">
        <property type="entry name" value="HFD_SUPT7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000034">
        <property type="entry name" value="STAGA complex 65 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039460">
        <property type="entry name" value="SUPT7L/Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28598:SF1">
        <property type="entry name" value="STAGA COMPLEX 65 SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="13">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="346"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00084075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013629.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="414" mass="46257" checksum="895E4ED2621EEB9D" modified="2022-01-19" version="1">MNLQRYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSANKPKPPTMLDIPSEPCSLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPLPSCPGSPPLPDDLLPLDCKNANALFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQAVATILAHAGFECANESVLETLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQVFHEVGIGSVLSLQKFWQHRIKDYHSYMLQISKQLSEEYERIVNPEKATEDTKPVKIKEEPVSDITFPVSEELEADLASGDQSLPMGVLGAQSERFPSNLEVEASPQASSAEVNASPLWNLTHVKMEPQESEEGNVSGHGVLGSDVFEEPMSGMSEAGIPQSPDDSDSSYGSHSTDSLMGSSPVFNQRCKKRMRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3J3</accession>
    <name>A0A8C5V3J3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AWAT2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03033642">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591701.1">
        <property type="nucleotide sequence ID" value="XM_012736247.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3J3"/>
    <dbReference type="Ensembl" id="ENSMICT00000015967.3">
        <property type="protein sequence ID" value="ENSMICP00000014556.2"/>
        <property type="gene ID" value="ENSMICG00000015973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855332"/>
    <dbReference type="GeneTree" id="ENSGT01030000234582"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050252">
        <property type="term" value="F:retinol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006640">
        <property type="term" value="P:monoacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010025">
        <property type="term" value="P:wax biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF12">
        <property type="entry name" value="ACYL-COA WAX ALCOHOL ACYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014556.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="38238" checksum="6EEA1F71844E1C16" modified="2022-01-19" version="1">MLLPSKKDLKTAMEVFAVFQWALSAFLIVITVILVNLYLVMFTPYWPATVLMLTWLAFDWKTPERGGRRFRCVRRWRLWRHYCNYFPLKLLKTHDISPSHNYILACHPHGLMSHACFGHFSTEMSGFSKIFPGITPYMLTLGAFFWVPFLREYVMATGACSVSQSSMDFLLTRRGTGNMLIVVVGGLAECRHSQPGSSTLVLKNRSGFVRMALRHGVALIPAYAFGETDLYDQHIFTPGALANRFQKWFRRMVHIYPCAFYGRGFTKNSWGFLPYTRPVTTVVGEPLPLPKIENPSQETVAKYHALYIDALRKLFDEHKTKFGISETQELVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3T7</accession>
    <name>A0A8C5V3T7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CCNO</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03016516">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631178.1">
        <property type="nucleotide sequence ID" value="XM_012775724.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3T7"/>
    <dbReference type="Ensembl" id="ENSMICT00000012724.3">
        <property type="protein sequence ID" value="ENSMICP00000011587.2"/>
        <property type="gene ID" value="ENSMICG00000012726.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877317"/>
    <dbReference type="KEGG" id="mmur:105877317"/>
    <dbReference type="CTD" id="10309"/>
    <dbReference type="GeneTree" id="ENSGT00940000155998"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034451">
        <property type="term" value="C:centriolar satellite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903251">
        <property type="term" value="P:multi-ciliated epithelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072520">
        <property type="term" value="P:seminiferous tubule development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20536">
        <property type="entry name" value="CYCLIN_CCNO_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20722">
        <property type="entry name" value="CYCLIN_CCNO_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000064">
        <property type="entry name" value="Cyclin O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000061">
        <property type="entry name" value="cyclin-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="140"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="12">
        <location>
            <begin position="233"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011587.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="352" mass="38459" checksum="066FC68DEAA52F2B" modified="2022-01-19" version="1">MVAPCPTSPASPATGVGRRDNDQNLRAPVKKSRRPRLRRKQPLQPLNPCSLPGDSGVCDLFESPSSGSDSADSPTAWAGRRCNPLPGPTQPLVQLDLQNFRDYGQSCYAFRKAQESHFHPRESLARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFLTTTPVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFSLGAPTISFFLEHFTHARVEAGQVEVSEALEAQALAQGVAELSLADYAFTSYAPSLLAICCLALADRMLRLPRAVDLSPGEHPEAALQDCLGKLQLLVAINSTSLTHMLPLEICEKCSLSPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V4U5</accession>
    <name>A0A8C5V4U5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MAST1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03027787">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027788">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000016239.3">
        <property type="protein sequence ID" value="ENSMICP00000014801.3"/>
        <property type="gene ID" value="ENSMICG00000016221.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157700"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043005">
        <property type="term" value="C:neuron projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23073">
        <property type="entry name" value="PDZ_MAST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05609">
        <property type="entry name" value="STKc_MAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001045">
        <property type="entry name" value="Microtubule-associated serine/threonine kinase 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000012">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1480.20:FF:000001">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000008">
        <property type="entry name" value="microtubule-associated serine/threonine-protein kinase 4 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.20">
        <property type="entry name" value="MAST3 pre-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037711">
        <property type="entry name" value="MAST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015022">
        <property type="entry name" value="MAST_pre-PK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023142">
        <property type="entry name" value="MAST_pre-PK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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        <source>
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        <source>
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    <sequence length="1525" mass="165393" checksum="EEFC643A29096662" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V6K6</accession>
    <name>A0A8C5V6K6_MICMU</name>
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        <recommendedName>
            <fullName evidence="4 15">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">HACD4</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(3R)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:39159"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:61526"/>
            <dbReference type="ChEBI" id="CHEBI:74278"/>
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        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:39160"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
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        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:45813"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Endoplasmic reticulum membrane</location>
            <topology evidence="15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
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        <property type="protein sequence ID" value="ENSMICP00000013133.3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:fatty acid elongation"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:sphingolipid biosynthetic process"/>
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        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
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        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE 4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
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    <keyword evidence="15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 15" id="KW-0275">Fatty acid biosynthesis</keyword>
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    <keyword evidence="5 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
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    <feature type="transmembrane region" description="Helical" evidence="15">
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013133.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="224" mass="26856" checksum="5150804A40BEACC8" modified="2022-01-19" version="1">MGRVALPAWLQPRYRKNAYLFIYYLIQFCGHSWIFTNMTVKFFHLKSKTPKSLFDNFHSCFHLLLHIYVGIESNHLLPRFLQLTERIIILFVVITSQEEVQEKYVVCVLFIFWNLLDMVRYTYNMLSVIGISYAILTWLSQTLWMLIYPLCVLAEAFAIYQSLPYFESFGTYSTKLPFDVSIYFPYVLKIYLMMLFIGMYFTYSHLYSERRDILGIFPVKKKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V7X3</accession>
    <name>A0A8C5V7X3_MICMU</name>
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        <submittedName>
            <fullName evidence="14">ATP binding cassette subfamily A member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ABCA10</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCA family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020280">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000017277.3">
        <property type="protein sequence ID" value="ENSMICP00000015737.3"/>
        <property type="gene ID" value="ENSMICG00000017260.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162673"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005319">
        <property type="term" value="F:lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03263">
        <property type="entry name" value="ABC_subfamily_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000335">
        <property type="entry name" value="ATP binding cassette subfamily A member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000436">
        <property type="entry name" value="ATP binding cassette subfamily A member 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026082">
        <property type="entry name" value="ABCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229:SF269">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19229">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12698">
        <property type="entry name" value="ABC2_membrane_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="893"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="932"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="985"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1046"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1071"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1116"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="391"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1202"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015737.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1544" mass="175495" checksum="4F79DB50C8774C67" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V915</accession>
    <name>A0A8C5V915_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 91</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC91</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03024504">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024505">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024506">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024507">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V915"/>
    <dbReference type="Ensembl" id="ENSMICT00000045477.2">
        <property type="protein sequence ID" value="ENSMICP00000017703.2"/>
        <property type="gene ID" value="ENSMICG00000043077.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015899"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090160">
        <property type="term" value="P:Golgi to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034592">
        <property type="entry name" value="CCDC91"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35072:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000017703.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="426" mass="48765" checksum="6A3DBA017A7D26DA" modified="2022-01-19" version="1">MDDDDFGGFEAAETFDGGNGETQTTSPAIPWAAFPTVSGVHLSPASPEIVLDHDHSSPSVGCLSSDAIISSPEDTHTDNNIIQQSRHTHLDISLFPLGLTDEKSNGTIALVDDSEDPGGNVSNMQLQQKISSLEIKLKVSEEEKQRIMKDVESLMEKHSVLEKDFLKEKEQEAISFQDRYKELQEKHKQELEDMRKAGHEALSIIVDEYKALLQSSVKQQVEAIEKQYISAIEKQAHKCEELLNAQHQRLLEMLDTEKELLKEKIKEALIQQSQEQKELLEKCLEEERQRNKEALVSAAKLEKEAMQDAVFKAIEEERKNLEKAHAEERELWKTEHAKDQEKVSQEIQKAIQEQRKISQETVKAAIIEEQKRSEKAVEEAVRRTRDELIEYVKEQKRLDQVIRQRSLSSLELFLSCAQKHITWPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V9S7</accession>
    <name>A0A8C5V9S7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Low-density lipoprotein receptor-related protein 1B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Low-density lipoprotein receptor-related protein-deleted in tumor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">LRP1B</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LDLR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011299">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011300">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011301">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000014950.3">
        <property type="protein sequence ID" value="ENSMICP00000013631.3"/>
        <property type="gene ID" value="ENSMICG00000014855.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157521"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043235">
        <property type="term" value="C:receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005041">
        <property type="term" value="F:low-density lipoprotein particle receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00112">
        <property type="entry name" value="LDLa"/>
        <property type="match status" value="29"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000022">
        <property type="entry name" value="LDL receptor related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000504">
        <property type="entry name" value="LDL receptor related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000012">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000007">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000008">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000010">
        <property type="entry name" value="Low density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000024">
        <property type="entry name" value="Low-density lipoprotein RecePtor related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000129">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000144">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000505">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000014">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000018">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000019">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000001">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000002">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000004">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000010">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000012">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000015">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000018">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000072">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000498">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000005">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000061">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000068">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000070">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000073">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000080">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000081">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000101">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000102">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000110">
        <property type="entry name" value="Low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000123">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000148">
        <property type="entry name" value="low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000088">
        <property type="entry name" value="Prolow-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000020">
        <property type="entry name" value="Prolow-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000028">
        <property type="entry name" value="prolow-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000029">
        <property type="entry name" value="prolow-density lipoprotein receptor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000009">
        <property type="entry name" value="Putative low-density lipoprotein receptor-related protein 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.400.10:FF:000065">
        <property type="entry name" value="Transmembrane protease serine 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.400.10">
        <property type="entry name" value="Low-density Lipoprotein Receptor"/>
        <property type="match status" value="32"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036055">
        <property type="entry name" value="LDL_receptor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051221">
        <property type="entry name" value="LDLR-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023415">
        <property type="entry name" value="LDLR_class-A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002172">
        <property type="entry name" value="LDrepeatLR_classA_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032485">
        <property type="entry name" value="LRP1-like_beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722:SF5">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22722">
        <property type="entry name" value="LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="18">Steroid 21-hydroxylase</fullName>
            <ecNumber evidence="17">1.14.14.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">21-OHase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Cytochrome P-450c21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Cytochrome P450 21</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytochrome P450 XXI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cytochrome P450-C21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30 32" type="primary">CYP21A2</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="26">A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 11-deoxycortisol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50308"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17252"/>
            <dbReference type="ChEBI" id="CHEBI:28324"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:50309"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 21-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50304"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16973"/>
            <dbReference type="ChEBI" id="CHEBI:17026"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:50305"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="27">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 28">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.16" evidence="17"/>
    <dbReference type="EMBL" id="ABDC03007279">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VC18"/>
    <dbReference type="Ensembl" id="ENSMICT00000016654.3">
        <property type="protein sequence ID" value="ENSMICP00000015176.2"/>
        <property type="gene ID" value="ENSMICG00000016652.3"/>
    </dbReference>
    <dbReference type="VGNC" id="VGNC:80513">
        <property type="gene designation" value="CYP21A2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158338"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103069">
        <property type="term" value="F:17-hydroxyprogesterone 21-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106309">
        <property type="term" value="F:progesterone 21-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004508">
        <property type="term" value="F:steroid 17-alpha-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005496">
        <property type="term" value="F:steroid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034651">
        <property type="term" value="P:cortisol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006705">
        <property type="term" value="P:mineralocorticoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042448">
        <property type="term" value="P:progesterone metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20674">
        <property type="entry name" value="CYP21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000049">
        <property type="entry name" value="steroid 21-hydroxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289">
        <property type="entry name" value="STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24289:SF17">
        <property type="entry name" value="STEROID 21-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 27 28" id="KW-0349">Heme</keyword>
    <keyword evidence="11 27 28" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 27 28" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 28" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="29" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0754">Steroid-binding</keyword>
    <keyword evidence="16" id="KW-0755">Steroidogenesis</keyword>
    <feature type="signal peptide" evidence="29">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034983429" description="Steroid 21-hydroxylase" evidence="29">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="27">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00044342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00051718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00052423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00057752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015176.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="VGNC" id="VGNC:80513"/>
        </source>
    </evidence>
    <sequence length="494" mass="56323" checksum="193A35ED36AD2B2A" modified="2022-01-19" version="1">MLLLGLLLLALLALLAGACLLWGQWKRRSLHLPPLAPGFLHLLRPNLPIYLLGLTQKFGPIYRLRLGLQEVVVLNSKRTIEEAMVRKWVDFAGRPEMLSYKLASQGYPDLSLGDYSLLWKAHKKLTRSALLLGIRSSMEPVMERLTQEFLERLRAQASTPVAIQKEFSFLTCSIICYLIFGDKIKDNLLHTFHDCVQEVMTLWDHWATQIVDIIPFLRFFPNPSLRRLKQAMEKRDHFVEKQLRWHKESLVAGQWRDMIDYMLQEVALPRVEESPGQLLEGHVHMSVVDLLIGGTETTATTLSWAVAFLLHHPEIQRRLQEELDLELGPSASGSWVSYKDRERLPLLNATIAEVLRLRPVVPLALPHRTTQPSSIFGYDIPEGTVVIPNLQGAHLDDTVWERAHEFWPDRFLQPGKSPRTLVFGCGARLCLGEPLARLELFVVLARLLQAFTLLPVGALPSLQPQPYFSLNLEIRPFQVWLQPRGMGGPNLGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VDW3</accession>
    <name>A0A8C5VDW3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L7-like 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011901">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VDW3"/>
    <dbReference type="Ensembl" id="ENSMICT00000041523.2">
        <property type="protein sequence ID" value="ENSMICP00000020735.2"/>
        <property type="gene ID" value="ENSMICG00000047228.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182878"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF13">
        <property type="entry name" value="RIBOSOMAL PROTEIN UL30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="95"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020735.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="29421" checksum="608AC8231CAE3ECB" modified="2022-01-19" version="1">MINTGKMAEQEERKKIPLVPENLLKKRKAYQALKATQAKQALLAKKEQRKGKGPRFKRLESFLHDSWRQQRDRVRLRRLEVKPHALKLPDKHSLAFVVRIQRINGVSSLVQKTIARLRLKKIFSGVFVRVTPQSLKLLRMVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLTDNTVIEEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLRPFQLSVARHATKNKVGFLKEMGSPGYRGERINQLIRQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VEE0</accession>
    <name>A0A8C5VEE0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LOC105868912</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013942">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VEE0"/>
    <dbReference type="Ensembl" id="ENSMICT00000033474.2">
        <property type="protein sequence ID" value="ENSMICP00000020615.2"/>
        <property type="gene ID" value="ENSMICG00000035596.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154488"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000478">
        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000725">
        <property type="entry name" value="zinc finger protein 205 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000135">
        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000011">
        <property type="entry name" value="zinc finger protein 615 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001266">
        <property type="entry name" value="Zinc finger protein 662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF23">
        <property type="entry name" value="ZINC FINGER PROTEIN 143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="326"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020615.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="422" mass="48054" checksum="E0330D58FA64B0A0" modified="2022-01-19" version="1">MPWVVALPELPHSESQVKTKYKLSSPKEKSSEEELQGLTQEIFPKGNPETFEFQQACRSEKGAEHSWKKFTIKARRKFFPQKRGLGQLVSSPLNTNTEEKYQQCNKLKKSFSLGTKPVVPPRDRPGEKASGLRLSDQGFPCQAGLSGPQTGPSRSKTQGCYVCGKSFSKNSHLIRHQKIHSREKPYVCMECGKKFNHNSLLLQHEKVHRGEKPYVCNECGKGFRETSKLAKHQRIHTGEKPYRCNECGKAFSGNSNLTKHQLIHTGEKPYNCHECGRAFNQKANLIKHQRIHTGEKPFECKECGKSFSQPSHLIHHQRMHSGEKPYKCNECGKGFSQTSHLVDHQRIHTGEKPYVCTVCKRGFIQMSHLIHHHRTHSGEKPHECSECGKCFSQSSTLIRHQVIHTMESAYELNERGQAFSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VFK1</accession>
    <name>A0A8C5VFK1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone-lysine N-methyltransferase SETMAR</fullName>
            <ecNumber evidence="12">2.1.1.357</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC105869397</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60308"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="2.1.1.357"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.357" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03028789">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VFK1"/>
    <dbReference type="Ensembl" id="ENSMICT00000049479.2">
        <property type="protein sequence ID" value="ENSMICP00000019703.2"/>
        <property type="gene ID" value="ENSMICG00000032203.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162663"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 26"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140954">
        <property type="term" value="F:histone H3K36 dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10544">
        <property type="entry name" value="SET_SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000041">
        <property type="entry name" value="Histone-lysine N-methyltransferase SETMAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="15">
        <location>
            <begin position="73"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="14">
        <location>
            <begin position="139"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="16">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019703.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="356" mass="39880" checksum="4F200ADD2D5F235F" modified="2022-01-19" version="1">MFVEAAEKRRPLRMAACEEAPAVPPGQVDVARGLENLPVSAWPPGAGPGPFQYTPDHVRGPGADMDPTQITFPGCICVKTPCLPGTCSCLHYEENYDANSCLRDTGWEAKYAKPVFECNVLCQCGDHCRNRVVQRGLQFHLQVFKTDKKGWGLRTLEFIPKGRFVCEYAGEVLGFSEAQRRIHLQTVCDSNYIIAIREHVYNGQIMETFVDPTYLGNIGRFLNHSCEPNLLMIPVRIDSMVPRLALFAAKDILPEEELSYDYSGRFLNLMDCEDKERLDEGKLRKPCYCGAKSCTAFLPFDSSLYGPLEKPKPSMCGPAPYAFLSSKQLTLEGSLVRGKQLAPLHKERWWLPGFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VGH3</accession>
    <name>A0A8C5VGH3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Barttin CLCNK type accessory subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">BSND</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03001446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001448">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VGH3"/>
    <dbReference type="Ensembl" id="ENSMICT00000042273.2">
        <property type="protein sequence ID" value="ENSMICP00000022631.2"/>
        <property type="gene ID" value="ENSMICG00000027495.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000008549"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017081">
        <property type="term" value="F:chloride channel regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007605">
        <property type="term" value="P:sensory perception of sound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029181">
        <property type="entry name" value="Barttin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28399">
        <property type="entry name" value="BARTTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28399:SF1">
        <property type="entry name" value="BARTTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15462">
        <property type="entry name" value="Barttin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022631.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="310" mass="33970" checksum="62BA34F12B6491AA" modified="2022-01-19" version="1">MADEKTFRIGFIVLGLFLLALGTFLMSHDRPQVYGTFYAMGSVMVIGGVIWSMCQCYPKVAFVPADSDFQGVLSPKALGLLENGLAADVRSPQPPYVRLWEEAAYDQSLPDFSHIQMKFMSYSEDPRPLLGPKLGTSGGEGGARDVQAWAEAAVVVHRGSEENEGEREPTQKLPSPLWFLPSCPQGPAPLASFQDDLDVGSSEDSSPNPSPPHPPPQEPRACWCPLDRYSDFALIDANMAEDVPQRGQQQEVALPNNWQRSPGTKEEEESSDPGTEEPEEEEEDLYYGLPDSPGDPLPDKELGFEPNAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VHV5</accession>
    <name>A0A8C5VHV5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="4">1.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Short-chain 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">HADH</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:30799"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31187"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62548"/>
            <dbReference type="ChEBI" id="CHEBI:62616"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31159"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57349"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62613"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homodimer. Interacts with GLUD1; this interaction inhibits the activation of glutamate dehydrogenase 1 (GLUD1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03030237">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621708.1">
        <property type="nucleotide sequence ID" value="XM_012766254.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VHV5"/>
    <dbReference type="Ensembl" id="ENSMICT00000038943.2">
        <property type="protein sequence ID" value="ENSMICP00000020063.1"/>
        <property type="gene ID" value="ENSMICG00000012822.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872330"/>
    <dbReference type="CTD" id="3033"/>
    <dbReference type="GeneTree" id="ENSGT00940000159984"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000019">
        <property type="entry name" value="3-hydroxybutyryl-CoA dehydrogenase FadB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000258">
        <property type="entry name" value="Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052242">
        <property type="entry name" value="Mito_3-hydroxyacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43561:SF3">
        <property type="entry name" value="HYDROXYACYL-COENZYME A DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="14" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11 25" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0744">Spermatogenesis</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="28">
        <location>
            <begin position="29"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="27">
        <location>
            <begin position="216"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="34"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="26">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="24">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00059837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00065273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00071676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00079904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="314" mass="34178" checksum="E7C45EB52AD2E86D" modified="2022-01-19" version="1">MAFVTRQFVRSVSSSSAASAAAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSRQGIEDSLRKVAKKKFAENPKAGDEFVEKTLSSISTSTDAAAVVHSTDLVVEAIVENLAVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPLMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAVRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFIMDGWHELDVKDPMFQPSPALNKLVAEKKLGRKTGEGFYKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJH4</accession>
    <name>A0A8C5VJH4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Growth arrest specific 2 like 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GAS2L2</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GAS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019973">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJH4"/>
    <dbReference type="Ensembl" id="ENSMICT00000032052.2">
        <property type="protein sequence ID" value="ENSMICP00000022303.1"/>
        <property type="gene ID" value="ENSMICG00000030480.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154849"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008093">
        <property type="term" value="F:cytoskeletal anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051764">
        <property type="term" value="P:actin crosslink formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001578">
        <property type="term" value="P:microtubule bundle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904825">
        <property type="term" value="P:protein localization to microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21268">
        <property type="entry name" value="CH_GAS2L1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000047">
        <property type="entry name" value="Growth arrest specific 2 like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756:SF14">
        <property type="entry name" value="GAS2-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46756">
        <property type="entry name" value="TRANSGELIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="32"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="215" mass="23798" checksum="D89C94997E24D5D7" modified="2022-01-19" version="1">MSQPGGHRRRPGTLGPPVRSIRPFRSSEQYLEAMKEDLAEWLRDLYGLDIDAANFLQVLETGLVLCRHANAVTEAALAFLAEAPARAQRIPMPRAGVRCNGAAQPGTFQARDNVSNFIQWCRKEMGIQEVLMFETEDLVLRKNVKNVVLCLLELGRRAWRFGVAAPTLVQLEEEIDQELRTELAPALPLPQPRPDGAEPGEPLHVPSAVPHGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VJI8</accession>
    <name>A0A8C5VJI8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SART1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633615.1">
        <property type="nucleotide sequence ID" value="XM_012778161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VJI8"/>
    <dbReference type="Ensembl" id="ENSMICT00000031490.2">
        <property type="protein sequence ID" value="ENSMICP00000019731.1"/>
        <property type="gene ID" value="ENSMICG00000030096.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878556"/>
    <dbReference type="KEGG" id="mmur:105878556"/>
    <dbReference type="CTD" id="9092"/>
    <dbReference type="GeneTree" id="ENSGT00390000007071"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015030">
        <property type="term" value="C:Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071005">
        <property type="term" value="C:U2-type precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045585">
        <property type="term" value="P:positive regulation of cytotoxic T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="423"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="807" mass="90723" checksum="CDF62BEB3D8282FC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VL12</accession>
    <name>A0A8C5VL12_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">CDK18</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03029896">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029897">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03029898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VL12"/>
    <dbReference type="Ensembl" id="ENSMICT00000046758.2">
        <property type="protein sequence ID" value="ENSMICP00000023257.2"/>
        <property type="gene ID" value="ENSMICG00000000060.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159482"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031643">
        <property type="term" value="P:positive regulation of myelination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000007">
        <property type="entry name" value="Cyclin-dependent kinase 14, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000061">
        <property type="entry name" value="Putative cyclin-dependent kinase 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF52">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="144"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023257.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="474" mass="54263" checksum="D9A2D26D8315B8F9" modified="2022-01-19" version="1">TIMNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRIEDLQLGPLGRDPPPEPGTFSPTDSGEEPGRPSPGMQYRRRQSQRRFSMEDISKRLSLPMDIRLPQEFLQKLQLESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTALSEFRTYSFPRYLPQPLISHAPRLDTDGISLLTGLLLYESKSRTSAEAALSHPYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKSRRQSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLG3</accession>
    <name>A0A8C5VLG3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DNMT3A</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03011918">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000041214.2">
        <property type="protein sequence ID" value="ENSMICP00000025378.1"/>
        <property type="gene ID" value="ENSMICG00000004108.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155459"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd11729">
        <property type="entry name" value="ADDz_Dnmt3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20154">
        <property type="entry name" value="PWWP_DNMT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.50">
        <property type="entry name" value="PWWP, helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025766">
        <property type="entry name" value="ADD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044108">
        <property type="entry name" value="ADD_DNMT3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054724">
        <property type="entry name" value="DNM3A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040552">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049554">
        <property type="entry name" value="DNMT3_ADD_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068:SF10">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23068">
        <property type="entry name" value="DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17980">
        <property type="entry name" value="ADD_DNMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22855">
        <property type="entry name" value="DNM3A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21255">
        <property type="entry name" value="DNMT3_ADD_GATA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00855">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00293">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51533">
        <property type="entry name" value="ADD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50812">
        <property type="entry name" value="PWWP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PWWP" evidence="13">
        <location>
            <begin position="292"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="482"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="246"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="912" mass="101967" checksum="E0CE12C6A7200865" modified="2025-10-08" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VLX6</accession>
    <name>A0A8C5VLX6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Leucine rich repeat and Ig domain containing 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">LINGO1</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03004928">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VLX6"/>
    <dbReference type="Ensembl" id="ENSMICT00000053005.2">
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        <property type="gene ID" value="ENSMICG00000007331.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154996"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20969">
        <property type="entry name" value="IgI_Lingo-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000076">
        <property type="entry name" value="Leucine-rich repeat and Ig domain-containing 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000014">
        <property type="entry name" value="Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013098">
        <property type="entry name" value="Ig_I-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003599">
        <property type="entry name" value="Ig_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003598">
        <property type="entry name" value="Ig_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050541">
        <property type="entry name" value="LRR_TM_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369">
        <property type="entry name" value="ANTIGEN BSP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24369:SF178">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07679">
        <property type="entry name" value="I-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00409">
        <property type="entry name" value="IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00408">
        <property type="entry name" value="IGc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
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        <property type="entry name" value="IG_LIKE"/>
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        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034511553" evidence="13">
        <location>
            <begin position="42"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="557"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="14">
        <location>
            <begin position="411"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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        <source>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023071.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="620" mass="69705" checksum="A52D16E95FF45453" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNZ8</accession>
    <name>A0A8C5VNZ8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="30">Histone-lysine N-methyltransferase ASH1L</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
            <ecNumber evidence="29">2.1.1.367</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="31">ASH1-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="32">Absent small and homeotic disks protein 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="40" type="primary">ASH1L</name>
    </gene>
    <organism evidence="40 41">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="40" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="40" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="40" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="28">Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-lysyl(9)-[histone H3] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(9)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60280"/>
            <dbReference type="Rhea" id="RHEA-COMP:15542"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="EC" id="2.1.1.367"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell junction</location>
            <location evidence="3">Tight junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EC" id="2.1.1.367" evidence="29"/>
    <dbReference type="EMBL" id="ABDC03003207">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003208">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003209">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003210">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003212">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000039406.2">
        <property type="protein sequence ID" value="ENSMICP00000024376.2"/>
        <property type="gene ID" value="ENSMICG00000007490.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156698"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005923">
        <property type="term" value="C:bicellular tight junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:decidualization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:flagellated sperm motility"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:inflammatory response"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:skeletal system development"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:1903699">
        <property type="term" value="P:tarsal gland development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:uterus morphogenesis"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="BAH_polybromo"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bromo_ASH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15548">
        <property type="entry name" value="PHD_ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19174">
        <property type="entry name" value="SET_ASH1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000025">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000011">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
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    </dbReference>
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        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043320">
        <property type="entry name" value="Bromo_ASH1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043319">
        <property type="entry name" value="PHD_ASH1L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46147">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ASH1"/>
        <property type="match status" value="1"/>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052253">
        <property type="entry name" value="CR1/CR2-DNA-binding_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006">
        <property type="entry name" value="PAPILLOMAVIRUS REGULATORY FACTOR PRF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13006:SF8">
        <property type="entry name" value="SLC2A4 REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01366">
        <property type="entry name" value="c-clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="362" mass="38173" checksum="2ED6C9636839B691" modified="2022-01-19" version="1">MEAERPPPRVVGRDPSVPLAEAPWLRAESPGPRAAPVTVPTPPQGPAASGGCAGLELALPQEPEPRAADLGAPGTWAGAAAGLPTPSAHIPVPAQRASPAAARLEEVMAAAALTSLSTSPLLLGAPAAAFSPEPGLEPWKEALARPPGSYSSSSASGEWGWDLASDQSSPSTPSPPLPLEAAHFLFGEPTLRKRKSSAQAMFQCLWKSCGKVLSSASGMQRHIRLVHLGRQAEPEQSDGEEDFYYTELDAGVDTLTDGLSSLTPASPTASLPPTFSRLELPESPVLTSMGAPQACHSDHAYPLEPQPTEVRACVPALPARMGVSLRKPRGDAKKCRKVYGMDHRDLWCTACRWKKACQRFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWI7</accession>
    <name>A0A8C5VWI7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 177</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM177 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03011376">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWI7"/>
    <dbReference type="Ensembl" id="ENSMICT00000045265.2">
        <property type="protein sequence ID" value="ENSMICP00000027744.1"/>
        <property type="gene ID" value="ENSMICG00000017224.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000010354"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026620">
        <property type="entry name" value="TMEM177"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21824:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="108" mass="12304" checksum="3ECD261C81B2ACC7" modified="2022-01-19" version="1">MAGPLWRAAAFVQRHRTGLLVGSCAGLFGAQISYHLFPDPVVQWLYHYWPQGQPAPLSPQLQRLFQEVLQDIGIPAGHSYKPFTAFTFQPARKEHRKVKKFPLNHKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWM1</accession>
    <name>A0A8C5VWM1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyroglutamylated RFamide peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">QRFP</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RFamide neuropeptide family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014942">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWM1"/>
    <dbReference type="Ensembl" id="ENSMICT00000015515.3">
        <property type="protein sequence ID" value="ENSMICP00000031713.2"/>
        <property type="gene ID" value="ENSMICG00000015518.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000015756"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005184">
        <property type="term" value="F:neuropeptide hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031854">
        <property type="term" value="F:orexigenic neuropeptide QRFP receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007218">
        <property type="term" value="P:neuropeptide signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024565">
        <property type="entry name" value="P518"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36476">
        <property type="entry name" value="OREXIGENIC NEUROPEPTIDE QRFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36476:SF1">
        <property type="entry name" value="OREXIGENIC NEUROPEPTIDE QRFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11109">
        <property type="entry name" value="RFamide_26RFa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0027">Amidation</keyword>
    <keyword evidence="5" id="KW-0527">Neuropeptide</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034079492" evidence="6">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031713.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="107" mass="11573" checksum="42EB39059DF99A99" modified="2022-01-19" version="1">MLSPHSLAYLLLLPLGPCFPPRDTGGPSDALGMIGARASWASLAEGPRPASSPRPQALLVEPKGLREHAGFRFRFGRQDEGREATSFWASVLLGNLAEELNGYSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VX13</accession>
    <name>A0A8C5VX13_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hedgehog acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">HHAT</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the membrane-bound acyltransferase family. HHAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029974">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012637159.1">
        <property type="nucleotide sequence ID" value="XM_012781705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VX13"/>
    <dbReference type="Ensembl" id="ENSMICT00000029603.2">
        <property type="protein sequence ID" value="ENSMICP00000028830.1"/>
        <property type="gene ID" value="ENSMICG00000017324.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105880558"/>
    <dbReference type="CTD" id="55733"/>
    <dbReference type="GeneTree" id="ENSGT00530000063629"/>
    <dbReference type="OrthoDB" id="420606at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016409">
        <property type="term" value="F:palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051085">
        <property type="entry name" value="MB_O-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13285:SF20">
        <property type="entry name" value="PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE HHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="493" mass="56853" checksum="CB9FD32B1AD82B81" modified="2022-01-19" version="1">MLPRWELSLYLLASLGFHFYSFYEVYKVSKEHEEELDREFELETDGLFGGLKKDPTDFEWSFWMEWGKQWLVWLLLGHVAVSQMATLLARKHRPWILTGYGVWACWCVLGLPGVAMVLLHAIISFCVAQFRSLILSWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLEFCWRERPAERAAYSFPWLLAYVFYYPAFHNGPILGFPEFVTQMQQQEVGSPKASLRVLILGLGRLLLWWWLAELMVHLMYMHAIYGSVPLLGAVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLKPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPVGGSQHGLLGTLFSTAMTFAFVSYWHGGYDYLWCWAALNWLGVTVENGVRRLVETPCIRDSLARHLSPGVRRRLHAALASCSTSILILSNLVFLGGNQVGKTYWNRIFVQGWPGVTLSVLGFLYCYAHVGIAWAQTYATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0W9</accession>
    <name>A0A8C5W0W9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">DDX55</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probable ATP-binding RNA helicase. Has ATPase activity and is involved in the maturation of precursor large subunit rRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with 28S rRNA. Interacts with double-stranded RNA substrates in vitro; the interaction stimulates ATPase activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03024801">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03024802">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W0W9"/>
    <dbReference type="Ensembl" id="ENSMICT00000045062.2">
        <property type="protein sequence ID" value="ENSMICP00000031067.2"/>
        <property type="gene ID" value="ENSMICG00000006477.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074969"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001022">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="40"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="241"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031067.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="578" mass="65825" checksum="37E56D7FC03AC88A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W4F0</accession>
    <name>A0A8C5W4F0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003747">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W4F0"/>
    <dbReference type="Ensembl" id="ENSMICT00000032657.2">
        <property type="protein sequence ID" value="ENSMICP00000036685.2"/>
        <property type="gene ID" value="ENSMICG00000031235.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01110000267902"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05768">
        <property type="entry name" value="IgC1_CH3_IgAGD_CH4_IgAEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000463">
        <property type="entry name" value="Immunoglobulin heavy constant gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003006">
        <property type="entry name" value="Ig/MHC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050380">
        <property type="entry name" value="Immune_Resp_Modulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23411">
        <property type="entry name" value="TAPASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00290">
        <property type="entry name" value="IG_MHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036685.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="131" mass="14422" checksum="ADD0B5D90D6FA70A" modified="2022-01-19" version="1">GDNFRPQVHLLPPPSEELALNELVSLTCLVRGFSPEQVLVRWLRGSQELPPGDYLTWPSRQEPGQGASTFAVTSVLRVTAESWKNGDNFSCMVGHEALPRAFTQKTIDRLSGKPTHVNVSVVMAEVDGTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W507</accession>
    <name>A0A8C5W507_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">LOC105877511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Early endosome membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001524">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W507"/>
    <dbReference type="Ensembl" id="ENSMICT00000043666.2">
        <property type="protein sequence ID" value="ENSMICP00000033346.2"/>
        <property type="gene ID" value="ENSMICG00000031270.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01000000214440"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15876">
        <property type="entry name" value="SNARE_syntaxin12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000016">
        <property type="entry name" value="Syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF88">
        <property type="entry name" value="SYNTAXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033346.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="237" mass="26892" checksum="27170100DEEBA504" modified="2022-01-19" version="1">MSYGPLDMYWNPGPSDPQLRDFSSSIQTCSGNIQWISQATAQIKNVMSQLGTKQDSSKLQENLQQLQHYTNQLGPSETSEGTPHQWLLCSLQQFPGCEKESIARARAGPCLSAEKRQREEQLVSFDSHEEWNQMQSQEDEVAITEETAIWQLEANILDVSQIFKDLAVMIHDQGDLIDSIEANVESSEVHVERATDQLQRAAYYQKKSCKKMCIPVLVLSMIIVILGLIIWLVYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XD29</accession>
    <name>A0A8C5XD29_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">KASH domain containing 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">KASH5</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03026870">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03026871">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XD29"/>
    <dbReference type="Ensembl" id="ENSMICT00000009294.3">
        <property type="protein sequence ID" value="ENSMICP00000008467.3"/>
        <property type="gene ID" value="ENSMICG00000009290.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00420000029926"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000800">
        <property type="term" value="C:lateral element"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034993">
        <property type="term" value="C:meiotic nuclear membrane microtubule tethering complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090619">
        <property type="term" value="C:meiotic spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045141">
        <property type="term" value="P:meiotic telomere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048477">
        <property type="term" value="P:oogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007283">
        <property type="term" value="P:spermatogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051653">
        <property type="term" value="P:spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028170">
        <property type="entry name" value="KASH5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028168">
        <property type="entry name" value="KASH5_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039508">
        <property type="entry name" value="KASH5_EF-hand-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47300">
        <property type="entry name" value="PROTEIN KASH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47300:SF1">
        <property type="entry name" value="PROTEIN KASH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14658">
        <property type="entry name" value="EF-hand_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14662">
        <property type="entry name" value="KASH_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Protein KASH5 EF-hand-like" evidence="4">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="KASH5-like coiled-coil" evidence="5">
        <location>
            <begin position="158"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="416"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008467.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="566" mass="63388" checksum="534F00F2B1432C0D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XE11</accession>
    <name>A0A8C5XE11_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">UBE2D4</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03015814">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03015816">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012596991.1">
        <property type="nucleotide sequence ID" value="XM_012741537.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XE11"/>
    <dbReference type="Ensembl" id="ENSMICT00000013290.3">
        <property type="protein sequence ID" value="ENSMICP00000012118.2"/>
        <property type="gene ID" value="ENSMICG00000013289.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105858417"/>
    <dbReference type="CTD" id="51619"/>
    <dbReference type="GeneTree" id="ENSGT00940000155109"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070936">
        <property type="term" value="P:protein K48-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000101">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="8">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012118.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="147" mass="16618" checksum="BEF7041DBC79AEB8" modified="2022-01-19" version="1">MALKRIQKELSDLQRDPPAQCSAGPVGNDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPEIAHIYKADKEKYNRLAREWTQKYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEX9</accession>
    <name>A0A8C5XEX9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CD1e molecule</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">CD1E</name>
        <name evidence="12" type="synonym">LOC105862424</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003126">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEX9"/>
    <dbReference type="Ensembl" id="ENSMICT00000016775.3">
        <property type="protein sequence ID" value="ENSMICP00000015295.3"/>
        <property type="gene ID" value="ENSMICG00000010222.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105862424"/>
    <dbReference type="GeneTree" id="ENSGT01120000271825"/>
    <dbReference type="OrthoDB" id="8890485at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030883">
        <property type="term" value="F:endogenous lipid antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030884">
        <property type="term" value="F:exogenous lipid antigen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071723">
        <property type="term" value="F:lipopeptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048006">
        <property type="term" value="P:antigen processing and presentation, endogenous lipid antigen via MHC class Ib"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048007">
        <property type="term" value="P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001916">
        <property type="term" value="P:positive regulation of T cell mediated cytotoxicity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21029">
        <property type="entry name" value="IgC1_CD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000254">
        <property type="entry name" value="Antigen-presenting glycoprotein CD1d1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.500.10:FF:000002">
        <property type="entry name" value="Antigen-presenting glycoprotein CD1d1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.500.10">
        <property type="entry name" value="MHC class I-like antigen recognition-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003597">
        <property type="entry name" value="Ig_C1-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050208">
        <property type="entry name" value="MHC_class-I_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011161">
        <property type="entry name" value="MHC_I-like_Ag-recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037055">
        <property type="entry name" value="MHC_I-like_Ag-recog_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011162">
        <property type="entry name" value="MHC_I/II-like_Ag-recog"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675">
        <property type="entry name" value="MHC CLASS I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16675:SF146">
        <property type="entry name" value="T-CELL SURFACE GLYCOPROTEIN CD1E, MEMBRANE-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07654">
        <property type="entry name" value="C1-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16497">
        <property type="entry name" value="MHC_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00407">
        <property type="entry name" value="IGc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54452">
        <property type="entry name" value="MHC antigen-recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0391">Immunity</keyword>
    <keyword evidence="7" id="KW-0393">Immunoglobulin domain</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150279" evidence="10">
        <location>
            <begin position="19"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ig-like" evidence="11">
        <location>
            <begin position="197"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015295.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="394" mass="44158" checksum="5F39ED43FCD58142" modified="2022-01-19" version="1">MLLLLLLLLLFREFSCPGENTAAPQALGSHHPAAEEPISFRLLQISSFANHSWVRTQGSGWLGELQTHSWDDIVGTFRFLRPWSQGQFSKQELKNLQALLQLYLHVFPREVQTFASQFQLEYPFELQISAGCKMHAGKASEMFINGAYQGTDFLSFQGSSWVPSPAAGSRAQNVCKMLNRYRDIKEIVQSLFGHTCPRFLEGLLAAGKSELERQVKPEAWLSSGPSPGPGRLLLVCHVSGFYPKPVWVRWMRGELEQLGTQHSDLLPNADGTWYLQATLDVAAGEAAGLSCRVKHSSLGGQDIILYWGGYSILLILICLTVLVTLVMLVVVDLWFKKQCSNWNFVSPHGSGTAFPVRVNTQDTRGSGHQLCLAQESWIINRILKKWKTSLKQIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XME7</accession>
    <name>A0A8C5XME7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CAPZB</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Cytoplasm</location>
            <location evidence="2 12">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Myofibril</location>
            <location evidence="1">Sarcomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001948">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012643141.1">
        <property type="nucleotide sequence ID" value="XM_012787687.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XME7"/>
    <dbReference type="Ensembl" id="ENSMICT00000037180.2">
        <property type="protein sequence ID" value="ENSMICP00000037167.1"/>
        <property type="gene ID" value="ENSMICG00000014212.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105884014"/>
    <dbReference type="CTD" id="832"/>
    <dbReference type="GeneTree" id="ENSGT00390000017957"/>
    <dbReference type="OMA" id="WSNKYYP"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005903">
        <property type="term" value="C:brush border"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030863">
        <property type="term" value="C:cortical cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098686">
        <property type="term" value="C:hippocampal mossy fiber to CA3 synapse"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030027">
        <property type="term" value="C:lamellipodium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014069">
        <property type="term" value="C:postsynaptic density"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030017">
        <property type="term" value="C:sarcomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120212">
        <property type="term" value="C:sperm head-tail coupling apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071203">
        <property type="term" value="C:WASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030032">
        <property type="term" value="P:lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022604">
        <property type="term" value="P:regulation of cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010591">
        <property type="term" value="P:regulation of lamellipodium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.570:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000001">
        <property type="entry name" value="F-actin-capping protein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019771">
        <property type="entry name" value="F-actin_capping_bsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10619:SF1">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00192">
        <property type="entry name" value="FACTINCAPB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00231">
        <property type="entry name" value="F_ACTIN_CAPPING_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0117">Actin capping</keyword>
    <keyword evidence="9 12" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="301" mass="33723" checksum="113574A24FD97E40" modified="2022-01-19" version="1">MHPSRRSLPFPLNCQLVRVGTADYGGGTDQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPGLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XNT2</accession>
    <name>A0A8C5XNT2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Synaptotagmin 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SYT3</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptotagmin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026898">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XNT2"/>
    <dbReference type="Ensembl" id="ENSMICT00000032576.2">
        <property type="protein sequence ID" value="ENSMICP00000038351.1"/>
        <property type="gene ID" value="ENSMICG00000030095.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000161770"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070382">
        <property type="term" value="C:exocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017156">
        <property type="term" value="P:calcium-ion regulated exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903861">
        <property type="term" value="P:positive regulation of dendrite extension"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd08385">
        <property type="entry name" value="C2A_Synaptotagmin-1-5-6-9-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000011">
        <property type="entry name" value="Synaptotagmin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001565">
        <property type="entry name" value="Synaptotagmin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024">
        <property type="entry name" value="SYNAPTOTAGMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10024:SF176">
        <property type="entry name" value="SYNAPTOTAGMIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00360">
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
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                <person name="Puazo M."/>
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                <person name="Durand N."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
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                <person name="Raveendran M."/>
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                <person name="English A."/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
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                <person name="Jayaseelan J."/>
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                <person name="Lee S."/>
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                <person name="Quiroz J."/>
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                <person name="Durand N."/>
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                <person name="Yoder A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="62" mass="7105" checksum="7E1504E38437675C" modified="2022-01-19" version="1">MTLTRWTGMIIGGMVDARSIPVLAKWQNSYSIKAVLQELRHLMMSKENMKLPQPPEGQTYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XYN9</accession>
    <name>A0A8C5XYN9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leukocyte specific transcript 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">LST1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03007264">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XYN9"/>
    <dbReference type="Ensembl" id="ENSMICT00000064677.1">
        <property type="protein sequence ID" value="ENSMICP00000043510.1"/>
        <property type="gene ID" value="ENSMICG00000017357.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000112003"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016358">
        <property type="term" value="P:dendrite development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050672">
        <property type="term" value="P:negative regulation of lymphocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007775">
        <property type="entry name" value="Leukocyte-sp_tscrpt_1_LST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15452">
        <property type="entry name" value="LEUKOCYTE-SPECIFIC TRANSCRIPT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15452:SF5">
        <property type="entry name" value="LEUKOCYTE-SPECIFIC TRANSCRIPT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05083">
        <property type="entry name" value="LST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="98" mass="10793" checksum="EA5BD23927800DBA" modified="2022-01-19" version="1">MSPCKDGWCHYLYGGLGLGALLLLAVAILCACLCRLHRRVKRLERSWAQLSEQELHYASLQRLPVPSGQGPDPRGRDEEGTKADPSADYACIADKKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XZF9</accession>
    <name>A0A8C5XZF9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C-type lectin domain family 5 member A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-type lectin superfamily member 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Myeloid DAP12-associating lectin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">CLEC5A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03015148">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623505.1">
        <property type="nucleotide sequence ID" value="XM_012768051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XZF9"/>
    <dbReference type="Ensembl" id="ENSMICT00000059768.1">
        <property type="protein sequence ID" value="ENSMICP00000043411.1"/>
        <property type="gene ID" value="ENSMICG00000001118.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105873265"/>
    <dbReference type="CTD" id="23601"/>
    <dbReference type="GeneTree" id="ENSGT00910000144330"/>
    <dbReference type="OMA" id="WHWIDNS"/>
    <dbReference type="OrthoDB" id="7357196at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001618">
        <property type="term" value="F:virus receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030099">
        <property type="term" value="P:myeloid cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033033">
        <property type="term" value="P:negative regulation of myeloid cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002076">
        <property type="term" value="P:osteoblast development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001819">
        <property type="term" value="P:positive regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03593">
        <property type="entry name" value="CLECT_NK_receptors_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000065">
        <property type="entry name" value="C-type lectin domain family 5 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052869">
        <property type="entry name" value="CLEC5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033992">
        <property type="entry name" value="NKR-like_CTLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47536">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 5 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47536:SF1">
        <property type="entry name" value="C-TYPE LECTIN DOMAIN FAMILY 5 MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="78"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00068093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00076978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="188" mass="21299" checksum="ADFFB38CCB28ACC2" modified="2022-01-19" version="1">MNWHMIISGFIVVVLKVVGMTLFLLYFPQIFGKSNDGFIPTGSYETVSQIFGSLSPSPDSSIPTSSYGTVCPKEWDFYQGRCFFLSTSELSWNKSKDFCEREGATLAIVDTLEKLKFLQSITSAEKYFIGLIYQDAEKKWRWINNSAFNGNVTNWNQNFNCVTIGLTKTFDAALCDTSYRSICEKNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y0I7</accession>
    <name>A0A8C5Y0I7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein EFR3 homolog A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Protein EFR3-like</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">EFR3A</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and HYCC (HYCC1 or HYCC2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFR3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013446">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03013447">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y0I7"/>
    <dbReference type="Ensembl" id="ENSMICT00000061805.1">
        <property type="protein sequence ID" value="ENSMICP00000043773.1"/>
        <property type="gene ID" value="ENSMICG00000003585.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000002143"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098978">
        <property type="term" value="C:glutamatergic synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016082">
        <property type="term" value="P:synaptic vesicle priming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000347">
        <property type="entry name" value="EFR3 homolog A (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051851">
        <property type="entry name" value="EFR3_Homologs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444:SF1">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12444">
        <property type="entry name" value="PROTEIN EFR3 HOMOLOG CMP44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00057442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="846" mass="95784" checksum="4A387CDC86B64C86" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1D6</accession>
    <name>A0A8C5Y1D6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-wave-sensitive opsin 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Blue cone photoreceptor pigment</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Blue-sensitive opsin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="primary">OPN1SW</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="27" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Photoreceptor outer segment</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 24">Membrane</location>
            <topology evidence="1 24">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Photoreceptor inner segment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015254">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644610.1">
        <property type="nucleotide sequence ID" value="XM_012789156.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y1D6"/>
    <dbReference type="Ensembl" id="ENSMICT00000069310.1">
        <property type="protein sequence ID" value="ENSMICP00000044296.1"/>
        <property type="gene ID" value="ENSMICG00000045275.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105884845"/>
    <dbReference type="KEGG" id="mmur:105884845"/>
    <dbReference type="CTD" id="611"/>
    <dbReference type="GeneTree" id="ENSGT01030000234549"/>
    <dbReference type="OMA" id="QTAFMGF"/>
    <dbReference type="OrthoDB" id="6142583at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120199">
        <property type="term" value="C:cone photoreceptor outer segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097381">
        <property type="term" value="C:photoreceptor disc membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001917">
        <property type="term" value="C:photoreceptor inner segment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15076">
        <property type="entry name" value="7tmA_SWS1_opsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000018">
        <property type="entry name" value="Rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
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        <property type="entry name" value="Opsin"/>
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        <property type="entry name" value="Opsin_blue"/>
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        <property type="entry name" value="Retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24240">
        <property type="entry name" value="OPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00001">
        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="OPSIN"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
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        <location>
            <begin position="35"/>
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            <begin position="151"/>
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            <begin position="200"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="252"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
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            <begin position="286"/>
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    </feature>
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            <begin position="52"/>
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            <dbReference type="RuleBase" id="RU004951"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50262"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044296.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="349" mass="39324" checksum="D3DD92ECD93AA8A8" modified="2022-01-19" version="1">MSKMSGEEEFYLFKNLSSVGPWDGPQYHIAPVWTFYLQAVFMGFVFFAGTPLNVMVLVATLRYKKLRQPLNYILVNLSFGGFLSCIFSVLPVFIASCRGYFLFGRHVCALEGFLGCAAGLVIGWSLAFLAFERYVVICKPFGNFRFSSRHALMVVLATWAIGIGVSIPPFFGWSRFIPEGLQCSCGPDWYTVDTKYRSEYYTWFLFLFCFIVPLSLICFSYSQLLQALRAVAAQQQESATTQKAEREVSRMVVVMVGSFCLCYVPYAALAMYIVNNRNHGLDLRLVTIPAFFSKSACVYNPIIYCFMNKQFQACIMEMVCGKAMTDESDTSSSQKTEISTFSSSQVGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y2K8</accession>
    <name>A0A8C5Y2K8_MICMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="primary">CUNH4orf36</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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            <dbReference type="Ensembl" id="ENSMICP00000045312.1"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="110" mass="12793" checksum="E9662466257DF0A4" modified="2022-01-19" version="1">MAYGLPRKNTVKTILRGSCYEVQEAWDLALLTKTFYTNLANMKLPFLGEIKFGNPLKLTRYKTMKDGLLISAESLKLERECELKRLNKHKCQETTSRELQLLLRERQTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y3H0</accession>
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        <name evidence="14" type="primary">INHBC</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
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            <taxon>Strepsirrhini</taxon>
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            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TGF-beta family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="ENSMICP00000045684.1"/>
        <property type="gene ID" value="ENSMICG00000043104.1"/>
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    <dbReference type="OMA" id="GIDCQGG"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:growth factor activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19406">
        <property type="entry name" value="TGF_beta_INHBC_E"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Inhibin beta A chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cystine-knot_cytokine"/>
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        <property type="entry name" value="Inhibin_betaC"/>
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        <property type="entry name" value="TGF-b_C"/>
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        <property type="entry name" value="TGF-beta-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017948">
        <property type="entry name" value="TGFb_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848:SF130">
        <property type="entry name" value="INHIBIN BETA C CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11848">
        <property type="entry name" value="TGF-BETA FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00019">
        <property type="entry name" value="TGF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00672">
        <property type="entry name" value="INHIBINBC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00204">
        <property type="entry name" value="TGFB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="Cystine-knot cytokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00250">
        <property type="entry name" value="TGF_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51362">
        <property type="entry name" value="TGF_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0339">Growth factor</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034513660" evidence="12">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="TGF-beta family profile" evidence="13">
        <location>
            <begin position="231"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000045684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="351" mass="37955" checksum="F69E7D8037C25C74" modified="2022-01-19" version="1">MTSSLLLAFLFLAPVTVATPRAGGQCPACGGPALDLESQRELLLDLAKRSILDKLHLSQRPTLSRPVSKTALRTALQRLHGPPQGALPEDDRGQECEIISFAKTGLSNVNQTRLDFHFSDTTAGGMEVQQASLMFFVQLPLNTTWTLKVRVLVLGLHGTNLTLANQHLLEVDASGWHQLLLGPEAQAAYSQGHLTLELVPEGQVAQSPVILAGAAHRPFVTVQVRVGGKHRVRRRGIDCQGGSRMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCTGQCPLHVAGMPGIAASFHTSVLNLLKANTAAGTAGGGSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVDACGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y487</accession>
    <name>A0A8C5Y487_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Asporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ASPN</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Secreted</location>
            <location evidence="1 10">Extracellular space</location>
            <location evidence="1 10">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014118">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014119">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602590.2">
        <property type="nucleotide sequence ID" value="XM_012747136.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602592.2">
        <property type="nucleotide sequence ID" value="XM_012747138.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602593.2">
        <property type="nucleotide sequence ID" value="XM_012747139.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602594.2">
        <property type="nucleotide sequence ID" value="XM_012747140.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y487"/>
    <dbReference type="Ensembl" id="ENSMICT00000067343.1">
        <property type="protein sequence ID" value="ENSMICP00000044990.1"/>
        <property type="gene ID" value="ENSMICG00000003189.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861568"/>
    <dbReference type="KEGG" id="mmur:105861568"/>
    <dbReference type="CTD" id="54829"/>
    <dbReference type="GeneTree" id="ENSGT00940000157444"/>
    <dbReference type="OMA" id="INDFCPT"/>
    <dbReference type="OrthoDB" id="1111193at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000038">
        <property type="entry name" value="Biglycan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000372">
        <property type="entry name" value="LRRNT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016352">
        <property type="entry name" value="SLRP_I_decor/aspor/byglycan"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF2">
        <property type="entry name" value="ASPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01462">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002490">
        <property type="entry name" value="SLRP_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00013">
        <property type="entry name" value="LRRNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150452" description="Asporin" evidence="13">
        <location>
            <begin position="16"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="LRRNT" evidence="14">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="68"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR002490-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="373" mass="42663" checksum="1261A8C1EBB0E552" modified="2022-01-19" version="1">MKEYMLLLFLALCSAKPFFSPSHITLKNMMLKDMEDTDDNDDDDDDNSLFPTKEPRSPFFPFDLFPTCPFGCQCYSRVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDNDGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPSTLLELHLDFNKISTVEQEDFKRYKELQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPAAFRCVLSRMSVQLANFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y663</accession>
    <name>A0A8C5Y663_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017197">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y663"/>
    <dbReference type="Ensembl" id="ENSMICT00000062523.1">
        <property type="protein sequence ID" value="ENSMICP00000046101.1"/>
        <property type="gene ID" value="ENSMICG00000035316.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000168566"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11264" checksum="EBF77A0EDC07FFDC" modified="2022-01-19" version="1">MLSAQGSLVANRGRRFQWAIELSGPGGGSRGRNSLYPVGYLDKQVPDTSVQETDCILVEKRYGASLLHPDMVEDMNKLPWDTKVLNSFTRAPPSAPKYLLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y6I3</accession>
    <name>A0A8C5Y6I3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">palmitoyl-protein hydrolase</fullName>
            <ecNumber evidence="3">3.1.2.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ABHD17A</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>S-hexadecanoyl-L-cysteinyl-[protein] + H2O = L-cysteinyl-[protein] + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19233"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="3.1.2.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Dendritic spine</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Postsynaptic density membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the AB hydrolase superfamily. ABHD17 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03027998">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601124.1">
        <property type="nucleotide sequence ID" value="XM_012745670.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y6I3"/>
    <dbReference type="Ensembl" id="ENSMICT00000059044.1">
        <property type="protein sequence ID" value="ENSMICP00000046245.1"/>
        <property type="gene ID" value="ENSMICG00000013508.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860734"/>
    <dbReference type="KEGG" id="mmur:105860734"/>
    <dbReference type="CTD" id="81926"/>
    <dbReference type="GeneTree" id="ENSGT00940000155854"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043197">
        <property type="term" value="C:dendritic spine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098839">
        <property type="term" value="C:postsynaptic density membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099175">
        <property type="term" value="P:regulation of postsynapse organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000008">
        <property type="entry name" value="Alpha/beta hydrolase domain-containing protein 17B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF52">
        <property type="entry name" value="ALPHA_BETA HYDROLASE DOMAIN-CONTAINING PROTEIN 17A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0628">Postsynaptic cell membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="16">
        <location>
            <begin position="110"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="309" mass="34008" checksum="69464C6CB2DFE61A" modified="2022-01-19" version="1">MNGLSVSELCCLFCCPPCPGRIAAKLAFLPPEPTYSLLPEPEPGPGGAGAAPSGTLRTSGNPGRWKLHLTERADFQYSQRELDTIEVFLTKSARGNRISCMYVRCVPGARYTVLFSHGNAVDLGQMCSFYIGLGSRIHCNVFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTRKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YA97</accession>
    <name>A0A8C5YA97_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein JTB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">JTB</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.</text>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with AURKA, AURKB, BIRC5 and INCENP. May be a component of the CPC at least composed of BIRC5/survivin, CDCA8/borealin, INCENP and AURKB/Aurora-B.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Microtubule organizing center</location>
            <location evidence="3">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the JTB family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003231">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646708.1">
        <property type="nucleotide sequence ID" value="XM_012791254.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YA97"/>
    <dbReference type="Ensembl" id="ENSMICT00000062875.1">
        <property type="protein sequence ID" value="ENSMICP00000048090.1"/>
        <property type="gene ID" value="ENSMICG00000010337.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885927"/>
    <dbReference type="KEGG" id="mmur:105885927"/>
    <dbReference type="CTD" id="10899"/>
    <dbReference type="GeneTree" id="ENSGT00390000016136"/>
    <dbReference type="OMA" id="EECHPCS"/>
    <dbReference type="OrthoDB" id="5971907at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030496">
        <property type="term" value="C:midbody"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008637">
        <property type="term" value="P:apoptotic mitochondrial changes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000281">
        <property type="term" value="P:mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042127">
        <property type="term" value="P:regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.220:FF:000001">
        <property type="entry name" value="Jumping translocation breakpoint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008657">
        <property type="entry name" value="JTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041">
        <property type="entry name" value="JTB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13041:SF3">
        <property type="entry name" value="PROTEIN JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05439">
        <property type="entry name" value="JTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150510" description="Protein JTB" evidence="20">
        <location>
            <begin position="31"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="146" mass="16411" checksum="AB6CF7C6693A579C" modified="2022-01-19" version="1">MPAGAGRRGLPHGRHLCWLLCAFTLKLCQAEAPVQEEKLSVSTSNLPCWMVEEFVVAEECTPCSNFKTKTTPECSSTGYVEKIICSSSKKNEFKSCRSALMEQHLFWKFEGAVVGVALIFACLVIIRQRQLDRKALEKVRKQIESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YB80</accession>
    <name>A0A8C5YB80_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="35">Arachidonate 12-lipoxygenase, 12S type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="35" type="primary">ALOX12</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="35" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate</text>
            <dbReference type="Rhea" id="RHEA:50276"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:131965"/>
            <dbReference type="ChEBI" id="CHEBI:132063"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:50277"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate</text>
            <dbReference type="Rhea" id="RHEA:50284"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:131964"/>
            <dbReference type="ChEBI" id="CHEBI:132065"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:50285"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (14S)-hydroperoxy-(4Z,7Z,10Z,12E,16Z,19Z)-docosahexaenoate</text>
            <dbReference type="Rhea" id="RHEA:41332"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:77016"/>
            <dbReference type="ChEBI" id="CHEBI:78048"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:41333"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:10428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57444"/>
            <dbReference type="EC" id="1.13.11.31"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:10429"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate</text>
            <dbReference type="Rhea" id="RHEA:16869"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:32395"/>
            <dbReference type="ChEBI" id="CHEBI:57446"/>
            <dbReference type="EC" id="1.13.11.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:16870"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,14S)-dihydroperoxy-(4Z,8E,10Z,12E,16Z,19Z)-docosahexaenoate</text>
            <dbReference type="Rhea" id="RHEA:64724"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:156049"/>
            <dbReference type="ChEBI" id="CHEBI:156082"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:64725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(7S)-hydroperoxy-(4Z,8E,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (7S,17S)-dihydroperoxy-(4Z,8E,10Z,13Z,15E,19Z)-docosahexaenoate</text>
            <dbReference type="Rhea" id="RHEA:64728"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:140349"/>
            <dbReference type="ChEBI" id="CHEBI:156049"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:64729"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-L-alanine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-alanine</text>
            <dbReference type="Rhea" id="RHEA:50172"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:132071"/>
            <dbReference type="ChEBI" id="CHEBI:132074"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="27">
            <dbReference type="Rhea" id="RHEA:50173"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-L-alanine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-alanine</text>
            <dbReference type="Rhea" id="RHEA:50184"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:132071"/>
            <dbReference type="ChEBI" id="CHEBI:132077"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:50185"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-gamma-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:50176"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:132072"/>
            <dbReference type="ChEBI" id="CHEBI:132075"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:50177"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-gamma-aminobutanoate + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-gamma-aminobutanoate</text>
            <dbReference type="Rhea" id="RHEA:50180"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:132072"/>
            <dbReference type="ChEBI" id="CHEBI:132078"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-glycine</text>
            <dbReference type="Rhea" id="RHEA:50168"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
            <dbReference type="ChEBI" id="CHEBI:132073"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:50169"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-glycine</text>
            <dbReference type="Rhea" id="RHEA:50188"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:59002"/>
            <dbReference type="ChEBI" id="CHEBI:132076"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:50189"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoyl-taurine</text>
            <dbReference type="Rhea" id="RHEA:50160"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:132060"/>
            <dbReference type="ChEBI" id="CHEBI:132061"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:50161"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-taurine + O2 = N-(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-taurine</text>
            <dbReference type="Rhea" id="RHEA:50156"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:132060"/>
            <dbReference type="ChEBI" id="CHEBI:132062"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:50157"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="28">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="28">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="24">Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 32">Belongs to the lipoxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020565">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YB80"/>
    <dbReference type="Ensembl" id="ENSMICT00000058400.1">
        <property type="protein sequence ID" value="ENSMICP00000048143.1"/>
        <property type="gene ID" value="ENSMICG00000014044.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155191"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <location>
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        <location>
            <position position="17"/>
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        <ligand>
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        <location>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Vertebrata</taxon>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
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            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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            <taxon>Microcebus</taxon>
        </lineage>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021774">
        <property type="entry name" value="CUPID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047176">
        <property type="entry name" value="FRMD4A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46079:SF1">
        <property type="entry name" value="FERM DOMAIN-CONTAINING PROTEIN 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11819">
        <property type="entry name" value="CUPID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01196">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47031">
        <property type="entry name" value="Second domain of FERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FERM C-terminal PH-like" evidence="5">
        <location>
            <begin position="189"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="786" mass="86962" checksum="C8C1DF1DF60F327B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YBZ1</accession>
    <name>A0A8C5YBZ1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Melanoma inhibitory activity protein 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">CTAGE family member 5 ER export factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">MIA2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum. Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with MIA3. Interacts with the COPII coat subunits SEC23A, SEC23B and maybe SEC24C. Interacts with PREB; recruits PREB to endoplasmic reticulum exit sites. Interacts with APOB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the MIA/OTOR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004184">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020141372.1">
        <property type="nucleotide sequence ID" value="XM_020285783.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000066740.1">
        <property type="protein sequence ID" value="ENSMICP00000048528.1"/>
        <property type="gene ID" value="ENSMICG00000004833.3"/>
    </dbReference>
    <dbReference type="CTD" id="4253"/>
    <dbReference type="GeneTree" id="ENSGT00950000182767"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035459">
        <property type="term" value="P:vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11892">
        <property type="entry name" value="SH3_MIA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000142">
        <property type="entry name" value="melanoma inhibitory activity protein 2 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051500">
        <property type="entry name" value="cTAGE_MIA/OTOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035555">
        <property type="entry name" value="MIA2_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158:SF38">
        <property type="entry name" value="MELANOMA INHIBITORY ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23158">
        <property type="entry name" value="MELANOMA INHIBITORY ACTIVITY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 15" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150531" description="Melanoma inhibitory activity protein 2" evidence="18">
        <location>
            <begin position="23"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="19">
        <location>
            <begin position="39"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="174"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="262"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1112"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1324"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1368"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="709"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="944"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1144"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="1156"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1174"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1398"/>
            <end position="1408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1408" mass="159536" checksum="C386AEB46C914E06" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6ECZ1</accession>
    <name>A0A8C6ECZ1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial</fullName>
            <ecNumber evidence="14">3.1.3.43</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein phosphatase 2C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pyruvate dehydrogenase phosphatase catalytic subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">PDP1</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.43"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:12670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.43" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03013174">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6ECZ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000044202.2">
        <property type="protein sequence ID" value="ENSMICP00000038157.2"/>
        <property type="gene ID" value="ENSMICG00000015194.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156368"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010510">
        <property type="term" value="P:regulation of pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF627">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE [ACETYL-TRANSFERRING]]-PHOSPHATASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 20" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="22">
        <location>
            <begin position="217"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00040842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038157.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="645" mass="71704" checksum="78F37842C43AD35F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EEJ9</accession>
    <name>A0A8C6EEJ9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CXXC-type zinc finger protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CpG-binding protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">PHD finger and CXXC domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">CXXC1</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03022211">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EEJ9"/>
    <dbReference type="Ensembl" id="ENSMICT00000034870.2">
        <property type="protein sequence ID" value="ENSMICP00000040008.2"/>
        <property type="gene ID" value="ENSMICG00000006424.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00730000111044"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045322">
        <property type="term" value="F:unmethylated CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd15553">
        <property type="entry name" value="PHD_Cfp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000138">
        <property type="entry name" value="CXXC-type zinc finger protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022056">
        <property type="entry name" value="CpG-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002857">
        <property type="entry name" value="Znf_CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12269">
        <property type="entry name" value="CpG_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02008">
        <property type="entry name" value="zf-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51058">
        <property type="entry name" value="ZF_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="17">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="CXXC-type" evidence="18">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="217"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="309"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="428"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="319"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00079319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040008.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="597" mass="67509" checksum="DA8F25A6327DB65B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EK70</accession>
    <name>A0A8C6EK70_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03002715">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EK70"/>
    <dbReference type="Ensembl" id="ENSMICT00000059716.1">
        <property type="protein sequence ID" value="ENSMICP00000047859.1"/>
        <property type="gene ID" value="ENSMICG00000042739.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00910000147804"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="53" mass="5969" checksum="D2E9475BFCEEC641" modified="2022-01-19" version="1">MELPTPFFIEGPPLDLIKVLLGYAAVFEMNISEKRNSVVYWGYPSTFSSLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKR6</accession>
    <name>A0A8C6EKR6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TBC1 domain family member 9B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">TBC1D9B</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a GTPase-activating protein for Rab family protein(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03023121">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03023123">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKR6"/>
    <dbReference type="Ensembl" id="ENSMICT00000065609.1">
        <property type="protein sequence ID" value="ENSMICP00000049719.1"/>
        <property type="gene ID" value="ENSMICG00000036875.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158554"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003008">
        <property type="term" value="P:system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13351">
        <property type="entry name" value="PH-GRAM1_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13354">
        <property type="entry name" value="PH-GRAM2_TCB1D9_TCB1D9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000013">
        <property type="entry name" value="Putative TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000041">
        <property type="entry name" value="TBC1 domain family member 9 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000002">
        <property type="entry name" value="TBC1 domain family member 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000130">
        <property type="entry name" value="TBC1 domain family member 9B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000033">
        <property type="entry name" value="TBC1 domain family member 9B isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036014">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036017">
        <property type="entry name" value="TCB1D9/TCB1D9B_PH-GRAM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666">
        <property type="entry name" value="PROTEIN VASCULAR ASSOCIATED DEATH 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47666:SF5">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="11">
        <location>
            <begin position="509"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="12">
        <location>
            <begin position="887"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="396"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1059"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1234" mass="138392" checksum="802CB40A1A431B09" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EBK0</accession>
    <name>A0A8B7EBK0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal Pro-X carboxypeptidase</fullName>
            <ecNumber evidence="14">3.4.16.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Proline carboxypeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Prolylcarboxypeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PRCP</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.</text>
            <dbReference type="EC" id="3.4.16.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.2" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03006543">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591565.1">
        <property type="nucleotide sequence ID" value="XM_012736111.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591566.1">
        <property type="nucleotide sequence ID" value="XM_012736112.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591567.1">
        <property type="nucleotide sequence ID" value="XM_012736113.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591568.1">
        <property type="nucleotide sequence ID" value="XM_012736114.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591569.1">
        <property type="nucleotide sequence ID" value="XM_012736115.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012591570.1">
        <property type="nucleotide sequence ID" value="XM_012736116.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020142226.1">
        <property type="nucleotide sequence ID" value="XM_020286637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EBK0"/>
    <dbReference type="Ensembl" id="ENSMICT00000045696.2">
        <property type="protein sequence ID" value="ENSMICP00000036374.2"/>
        <property type="gene ID" value="ENSMICG00000011983.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855250"/>
    <dbReference type="KEGG" id="mmur:105855250"/>
    <dbReference type="CTD" id="5547"/>
    <dbReference type="GeneTree" id="ENSGT00940000158099"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045178">
        <property type="term" value="C:basal part of cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060055">
        <property type="term" value="P:angiogenesis involved in wound healing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002003">
        <property type="term" value="P:angiotensin maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097009">
        <property type="term" value="P:energy homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042593">
        <property type="term" value="P:glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003085">
        <property type="term" value="P:negative regulation of systemic arterial blood pressure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002353">
        <property type="term" value="P:plasma kallikrein-kinin cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043535">
        <property type="term" value="P:regulation of blood vessel endothelial cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000377">
        <property type="term" value="P:regulation of reactive oxygen species metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002155">
        <property type="term" value="P:regulation of thyroid hormone receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000002">
        <property type="entry name" value="lysosomal Pro-X carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0458">Lysosome</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133313" description="Lysosomal Pro-X carboxypeptidase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036374.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="500" mass="56613" checksum="EE6EA58FFCF89E4B" modified="2022-01-19" version="1">MGRRALLLLLLAFLAPGAAITLRPTLRTLGSLHLPTSSTSRYAVARNYSVHYFQQKIDHFGFTIMKTFKQRYIIADKYWKKDGGSILFYTGNEGDIIWFCNNTGFMWDVAKELKAMLVFAEHRYYGESLPFGHSSYKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIALGGSYGGMLAAWFRMKYPHIVVGALAASAPILQFDNLIPCGVFMKIVTTDFRKSGPYCSESIRRSWDAINRLSNTGRGLRWLTEALHLCNPLDSQDIQHLKDWIAETWVNLAMVDYPYASNFLQPLPAWPIKVACQYLRNPNVSDSVLLENIFQALNVYYNYSGQAQCLNMSETTTRSLGSQGWSYQACTEMVMPFCTNGIDDMFEPRLWDLKEFSDDCFNHWGVRPRPSWISTLYGGKNISSHTNIVFSNGELDPWSGGGITEDITDTLVAITISEGAHHLDLRASNPLDPSSVLLARTLEVGHMKKWIKDFYGRAGKEELRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDJ3</accession>
    <name>A0A8B7EDJ3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G protein subunit beta 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">GNB4</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03000915">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592463.1">
        <property type="nucleotide sequence ID" value="XM_012737009.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592464.1">
        <property type="nucleotide sequence ID" value="XM_012737010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EDJ3"/>
    <dbReference type="SMR" id="A0A8B7EDJ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000073183.1">
        <property type="protein sequence ID" value="ENSMICP00000051355.1"/>
        <property type="gene ID" value="ENSMICG00000049251.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105855818"/>
    <dbReference type="KEGG" id="mmur:105855818"/>
    <dbReference type="CTD" id="59345"/>
    <dbReference type="GeneTree" id="ENSGT01000000214413"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="139"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000051355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="340" mass="37567" checksum="EDF085155A1EDC89" modified="2022-01-19" version="1">MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EDM9</accession>
    <name>A0A8B7EDM9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">SLC44A1</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014798">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012592253.1">
        <property type="nucleotide sequence ID" value="XM_012736799.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EDM9"/>
    <dbReference type="Ensembl" id="ENSMICT00000028972.2">
        <property type="protein sequence ID" value="ENSMICP00000033341.1"/>
        <property type="gene ID" value="ENSMICG00000012375.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105855715"/>
    <dbReference type="CTD" id="23446"/>
    <dbReference type="GeneTree" id="ENSGT00940000157174"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015220">
        <property type="term" value="F:choline transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF56">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="654" mass="73154" checksum="EFCD049E53DB81C6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EHN4</accession>
    <name>A0A8B7EHN4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="28">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="primary">SLC1A1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:71379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29990"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:82559"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>K(+)(in) + L-glutamate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-glutamate(in) + 3 Na(+)(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:70699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Apical cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Early endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Membrane</location>
            <topology evidence="28">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Recycling endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="21">Synapse</location>
            <location evidence="21">Synaptosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014374">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03014375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012593128.1">
        <property type="nucleotide sequence ID" value="XM_012737674.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EHN4"/>
    <dbReference type="Ensembl" id="ENSMICT00000005169.3">
        <property type="protein sequence ID" value="ENSMICP00000004713.2"/>
        <property type="gene ID" value="ENSMICG00000005171.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105856181"/>
    <dbReference type="KEGG" id="mmur:105856181"/>
    <dbReference type="CTD" id="6505"/>
    <dbReference type="GeneTree" id="ENSGT00940000155397"/>
    <dbReference type="OrthoDB" id="5877963at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030425">
        <property type="term" value="C:dendrite"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043025">
        <property type="term" value="C:neuronal cell body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098794">
        <property type="term" value="C:postsynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098685">
        <property type="term" value="C:Schaffer collateral - CA1 synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015108">
        <property type="term" value="F:chloride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033229">
        <property type="term" value="F:cysteine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140010">
        <property type="term" value="F:D-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005314">
        <property type="term" value="F:high-affinity L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005253">
        <property type="term" value="F:monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030534">
        <property type="term" value="P:adult behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001662">
        <property type="term" value="P:behavioral fear response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048514">
        <property type="term" value="P:blood vessel morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007420">
        <property type="term" value="P:brain development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071242">
        <property type="term" value="P:cellular response to ammonium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903926">
        <property type="term" value="P:cellular response to bisphenol A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071314">
        <property type="term" value="P:cellular response to cocaine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071288">
        <property type="term" value="P:cellular response to mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990708">
        <property type="term" value="P:conditioned place preference"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019221">
        <property type="term" value="P:cytokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070779">
        <property type="term" value="P:D-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042417">
        <property type="term" value="P:dopamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007212">
        <property type="term" value="P:G protein-coupled dopamine receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007215">
        <property type="term" value="P:glutamate receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007625">
        <property type="term" value="P:grooming behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060047">
        <property type="term" value="P:heart contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090461">
        <property type="term" value="P:intracellular glutamate homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140009">
        <property type="term" value="P:L-aspartate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098712">
        <property type="term" value="P:L-glutamate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007626">
        <property type="term" value="P:locomotory behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060291">
        <property type="term" value="P:long-term synaptic potentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035633">
        <property type="term" value="P:maintenance of blood-brain barrier"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007613">
        <property type="term" value="P:memory"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061744">
        <property type="term" value="P:motor behavior"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097049">
        <property type="term" value="P:motor neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043524">
        <property type="term" value="P:negative regulation of neuron apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022008">
        <property type="term" value="P:neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098877">
        <property type="term" value="P:neurotransmitter receptor transport to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006836">
        <property type="term" value="P:neurotransmitter transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010460">
        <property type="term" value="P:positive regulation of heart rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099170">
        <property type="term" value="P:postsynaptic modulation of chemical synaptic transmission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090313">
        <property type="term" value="P:regulation of protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001975">
        <property type="term" value="P:response to amphetamine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072347">
        <property type="term" value="P:response to anesthetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048678">
        <property type="term" value="P:response to axon injury"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036293">
        <property type="term" value="P:response to decreased oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043278">
        <property type="term" value="P:response to morphine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010842">
        <property type="term" value="P:retina layer formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060013">
        <property type="term" value="P:righting reflex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
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        <property type="term" value="P:synapse organization"/>
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        <property type="term" value="P:zinc ion transmembrane transport"/>
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        <property type="entry name" value="Amino acid transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Sodium:dicarboxylate symporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DAACS"/>
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        <property type="entry name" value="Na-dicarboxylate_symporter"/>
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        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
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        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11958">
        <property type="entry name" value="SODIUM/DICARBOXYLATE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SDF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EDTRNSPORT"/>
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    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA_DICARBOXYL_SYMP_1"/>
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        <property type="entry name" value="NA_DICARBOXYL_SYMP_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0868">Chloride</keyword>
    <keyword evidence="11" id="KW-0967">Endosome</keyword>
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    <keyword evidence="18 28" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0630">Potassium</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0915">Sodium</keyword>
    <keyword evidence="12 28" id="KW-0769">Symport</keyword>
    <keyword evidence="16" id="KW-0770">Synapse</keyword>
    <keyword evidence="8" id="KW-0771">Synaptosome</keyword>
    <keyword evidence="9 28" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 28" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 28" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="58"/>
            <end position="82"/>
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    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="94"/>
            <end position="116"/>
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    <feature type="transmembrane region" description="Helical" evidence="28">
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            <begin position="210"/>
            <end position="229"/>
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    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="250"/>
            <end position="271"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="28">
        <location>
            <begin position="283"/>
            <end position="308"/>
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            <dbReference type="ARBA" id="ARBA00004146"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004414"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004565"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022599"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
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        <source>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023214"/>
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            <dbReference type="ARBA" id="ARBA00034102"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00037996"/>
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            <dbReference type="ARBA" id="ARBA00045494"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047601"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048715"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00049118"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049885"/>
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    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="RuleBase" id="RU361216"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000004713.2"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="524" mass="57101" checksum="FA84BE133E8894EC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EM01</accession>
    <name>A0A8B7EM01_MICMU</name>
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        <recommendedName>
            <fullName evidence="2">C-X-C chemokine receptor type 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">High affinity interleukin-8 receptor B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">LOC105857711</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Interacts with IL8. Interacts with GNAI2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012740306.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000031906.1"/>
        <property type="gene ID" value="ENSMICG00000046166.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105857711"/>
    <dbReference type="KEGG" id="mmur:105857711"/>
    <dbReference type="GeneTree" id="ENSGT01050000244848"/>
    <dbReference type="OrthoDB" id="9946013at2759"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009897">
        <property type="term" value="C:external side of plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019957">
        <property type="term" value="F:C-C chemokine binding"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0016493">
        <property type="term" value="F:C-C chemokine receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0019959">
        <property type="term" value="F:interleukin-8 binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:interleukin-8 receptor activity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002407">
        <property type="term" value="P:dendritic cell chemotaxis"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:neutrophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007204">
        <property type="term" value="P:positive regulation of cytosolic calcium ion concentration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15178">
        <property type="entry name" value="7tmA_CXCR1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C-X-C chemokine receptor type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050119">
        <property type="entry name" value="CCR1-9-like"/>
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    <dbReference type="InterPro" id="IPR000057">
        <property type="entry name" value="Chemokine_CXCR2"/>
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    <dbReference type="InterPro" id="IPR000174">
        <property type="entry name" value="Chemokine_CXCR_1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
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        <property type="entry name" value="C-X-C CHEMOKINE RECEPTOR TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10489">
        <property type="entry name" value="CELL ADHESION MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="7tm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GPCRRHODOPSN"/>
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        <property type="entry name" value="INTRLEUKIN8R"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00573">
        <property type="entry name" value="INTRLEUKN8BR"/>
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    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
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        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11 17" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 17" id="KW-0807">Transducer</keyword>
    <keyword evidence="6 17 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="19">
        <location>
            <begin position="64"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="40252" checksum="B4F4A514462AAE7D" modified="2022-01-19" version="1">MEDVNWEDFILEDLLDGDFSNYTYSTDLHPILPDSAPCRPESLEINKYAVVITSALVFLLSLLGNSLVMLVILCSCVSRSITDVYLLNLAMADLLFALTLPIWAASKVNGWIFGTALCKLVSLLKEVNFYSGILLLACISVDRYLAIVHATRALTQKRHQVKFICLGTWALSLCLSLPVIIFRTTIYPPSSSPVCYEDMGNSTATWRMVLRILPQTFGFVLPLLVMLFCYGFTLRTLLKAHMGQKHRAMRVIFAVVLVFLLCWLPYHLVLLADTLRRTQVISETCKRGNDIDRALDATEILGFFHSCLNPFIYAFIGQKFRHGLLKILATHGLISKQFLPKDSRPSFAGSSSGNRSTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7ETF1</accession>
    <name>A0A8B7ETF1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Matrix metalloproteinase-9</fullName>
            <ecNumber evidence="4">3.4.24.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">92 kDa gelatinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">92 kDa type IV collagenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">Gelatinase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33 35" type="primary">MMP9</name>
    </gene>
    <organism evidence="35">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="33" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="33" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="35" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="35">Liver</tissue>
        </source>
    </reference>
    <reference evidence="33" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves NINJ1 to generate the Secreted ninjurin-1 form. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of gelatin types I and V and collagen types IV and V.</text>
            <dbReference type="EC" id="3.4.24.35"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="26">Can bind about 5 Ca(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="26">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="26">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="24">Exists as monomer or homodimer; disulfide-linked. Also exists as heterodimer with LCN2. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M10A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.35" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03021831">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598452.1">
        <property type="nucleotide sequence ID" value="XM_012742998.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7ETF1"/>
    <dbReference type="Ensembl" id="ENSMICT00000033023.2">
        <property type="protein sequence ID" value="ENSMICP00000021161.1"/>
        <property type="gene ID" value="ENSMICG00000011348.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859286"/>
    <dbReference type="KEGG" id="mmur:105859286"/>
    <dbReference type="CTD" id="4318"/>
    <dbReference type="GeneTree" id="ENSGT00940000157415"/>
    <dbReference type="OrthoDB" id="406838at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016477">
        <property type="term" value="P:cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071492">
        <property type="term" value="P:cellular response to UV-A"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030574">
        <property type="term" value="P:collagen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007566">
        <property type="term" value="P:embryo implantation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035987">
        <property type="term" value="P:endodermal cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022617">
        <property type="term" value="P:extracellular matrix disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904063">
        <property type="term" value="P:negative regulation of cation transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000697">
        <property type="term" value="P:negative regulation of epithelial cell differentiation involved in kidney development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001243">
        <property type="term" value="P:negative regulation of intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043065">
        <property type="term" value="P:positive regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045742">
        <property type="term" value="P:positive regulation of epidermal growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051549">
        <property type="term" value="P:positive regulation of keratinocyte migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090200">
        <property type="term" value="P:positive regulation of release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904707">
        <property type="term" value="P:positive regulation of vascular associated smooth muscle cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904645">
        <property type="term" value="P:response to amyloid-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00062">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00094">
        <property type="entry name" value="HX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04278">
        <property type="entry name" value="ZnMc_MMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000010">
        <property type="entry name" value="72 kDa type IV collagenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.10.10:FF:000001">
        <property type="entry name" value="Fibronectin 1a isoform 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.110.10.10:FF:000011">
        <property type="entry name" value="Matrix metalloproteinase-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.110.10.10">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000562">
        <property type="entry name" value="FN_type2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000585">
        <property type="entry name" value="Hemopexin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036375">
        <property type="entry name" value="Hemopexin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018487">
        <property type="entry name" value="Hemopexin-like_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018486">
        <property type="entry name" value="Hemopexin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033739">
        <property type="entry name" value="M10A_MMP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001818">
        <property type="entry name" value="Pept_M10_metallopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021190">
        <property type="entry name" value="Pept_M10A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021158">
        <property type="entry name" value="Pept_M10A_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201">
        <property type="entry name" value="MATRIX METALLOPROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10201:SF30">
        <property type="entry name" value="MATRIX METALLOPROTEINASE-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00040">
        <property type="entry name" value="fn2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00045">
        <property type="entry name" value="Hemopexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00413">
        <property type="entry name" value="Peptidase_M10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001191">
        <property type="entry name" value="Peptidase_M10A_matrix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00013">
        <property type="entry name" value="FNTYPEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00138">
        <property type="entry name" value="MATRIXIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00059">
        <property type="entry name" value="FN2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00120">
        <property type="entry name" value="HX"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50923">
        <property type="entry name" value="Hemopexin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="PGBD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00546">
        <property type="entry name" value="CYSTEINE_SWITCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00023">
        <property type="entry name" value="FN2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51092">
        <property type="entry name" value="FN2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00024">
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F1K2</accession>
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            <fullName evidence="11">Kinetochore protein NDC80</fullName>
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        <name evidence="17" type="primary">NDC80</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.</text>
    </comment>
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        <text evidence="11">Component of the NDC80 complex.</text>
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            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <text evidence="1 11">Belongs to the NDC80/HEC1 family.</text>
    </comment>
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        <property type="term" value="F:identical protein binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090267">
        <property type="term" value="P:positive regulation of mitotic cell cycle spindle assembly checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.30:FF:000002">
        <property type="entry name" value="NDC80, kinetochore complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040967">
        <property type="entry name" value="DUF5595"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057091">
        <property type="entry name" value="NDC80_loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18077">
        <property type="entry name" value="DUF5595"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24487">
        <property type="entry name" value="NDC80_loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="14">
        <location>
            <begin position="52"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5595" evidence="15">
        <location>
            <begin position="213"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Kinetochore protein NDC80 loop region" evidence="16">
        <location>
            <begin position="377"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="265"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="458"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF24487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000007633.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="642" mass="73683" checksum="9276479C43E10A54" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F2A8</accession>
    <name>A0A8B7F2A8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Zinc finger protein</fullName>
            <ecNumber evidence="18">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PRDM5</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="17">Interacts with EHMT2/G9A, GFI1 and HDAC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="18"/>
    <dbReference type="EMBL" id="ABDC03027984">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03027985">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601310.1">
        <property type="nucleotide sequence ID" value="XM_012745856.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F2A8"/>
    <dbReference type="Ensembl" id="ENSMICT00000043350.2">
        <property type="protein sequence ID" value="ENSMICP00000036177.1"/>
        <property type="gene ID" value="ENSMICG00000001459.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105860830"/>
    <dbReference type="CTD" id="11107"/>
    <dbReference type="GeneTree" id="ENSGT00940000158340"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19190">
        <property type="entry name" value="PR-SET_PRDM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000015">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000407">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000476">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000510">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000518">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000527">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000533">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000636">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000659">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000546">
        <property type="entry name" value="Zinc finger protein 333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000102">
        <property type="entry name" value="zinc finger protein 850 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044415">
        <property type="entry name" value="PRDM5_PR-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050331">
        <property type="entry name" value="Zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017125">
        <property type="entry name" value="Znf_PRDM5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16515:SF32">
        <property type="entry name" value="PR DOMAIN ZINC FINGER PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21549">
        <property type="entry name" value="PRDM2_PR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037162">
        <property type="entry name" value="PRDM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 18" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="21">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="20">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
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</entry>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
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                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
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                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
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                <person name="Xin Y."/>
                <person name="Han Y."/>
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                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F8K0</accession>
    <name>A0A8B7F8K0_MICMU</name>
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        <recommendedName>
            <fullName evidence="13">Catenin alpha-1</fullName>
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        <name evidence="15" type="primary">CTNNA1</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
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            <taxon>Primates</taxon>
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    <reference evidence="15" key="1">
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            <authorList>
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                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
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            <location evidence="4">Cell junction</location>
            <location evidence="4">Adherens junction</location>
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        <subcellularLocation>
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            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vinculin/alpha-catenin family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome 19"/>
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    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="C:flotillin complex"/>
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        <property type="term" value="F:cadherin binding"/>
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        <property type="term" value="P:negative regulation of integrin-mediated signaling pathway"/>
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        <property type="term" value="P:negative regulation of neuroblast proliferation"/>
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        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
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        <property type="term" value="P:smoothened signaling pathway"/>
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        <property type="entry name" value="Catenin alpha 1"/>
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        <property type="entry name" value="Catenin alpha-2 isoform 1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="1.20.120.230">
        <property type="entry name" value="Alpha-catenin/vinculin-like"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Alpha-catenin/vinculin-like_sf"/>
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    <dbReference type="InterPro" id="IPR001033">
        <property type="entry name" value="Alpha_catenin"/>
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    <dbReference type="InterPro" id="IPR006077">
        <property type="entry name" value="Vinculin/catenin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000633">
        <property type="entry name" value="Vinculin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18914">
        <property type="entry name" value="ALPHA CATENIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR18914:SF24">
        <property type="entry name" value="CATENIN ALPHA-1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01044">
        <property type="entry name" value="Vinculin"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00805">
        <property type="entry name" value="ALPHACATENIN"/>
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    <dbReference type="SUPFAM" id="SSF47220">
        <property type="entry name" value="alpha-catenin/vinculin-like"/>
        <property type="match status" value="4"/>
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    <dbReference type="PROSITE" id="PS00663">
        <property type="entry name" value="VINCULIN_1"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="864"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="906" mass="100086" checksum="DDDB981FD9B1B6C6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FAX8</accession>
    <name>A0A8B7FAX8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tyrosine-protein phosphatase non-receptor type</fullName>
            <ecNumber evidence="11">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PTPN4</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May act at junctions between the membrane and the cytoskeleton.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="11"/>
    <dbReference type="EMBL" id="ABDC03011378">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011379">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011380">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03011381">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605206.1">
        <property type="nucleotide sequence ID" value="XM_012749752.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FAX8"/>
    <dbReference type="Ensembl" id="ENSMICT00000038239.2">
        <property type="protein sequence ID" value="ENSMICP00000020721.1"/>
        <property type="gene ID" value="ENSMICG00000046058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105863015"/>
    <dbReference type="CTD" id="5775"/>
    <dbReference type="GeneTree" id="ENSGT00940000157211"/>
    <dbReference type="OrthoDB" id="5854685at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035254">
        <property type="term" value="F:glutamate receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd14473">
        <property type="entry name" value="FERM_B-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13189">
        <property type="entry name" value="FERM_C_PTPN4_PTPN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17194">
        <property type="entry name" value="FERM_F1_PTPN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06706">
        <property type="entry name" value="PDZ_PTPN3-4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000002">
        <property type="entry name" value="Band 4.1-like protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000045">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000104">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000023">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000003">
        <property type="entry name" value="Tyrosine-protein phosphatase non-receptor type 4"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR019749">
        <property type="entry name" value="Band_41_domain"/>
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    <dbReference type="InterPro" id="IPR014847">
        <property type="entry name" value="FA"/>
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    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035963">
        <property type="entry name" value="FERM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019748">
        <property type="entry name" value="FERM_central"/>
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    <dbReference type="InterPro" id="IPR019747">
        <property type="entry name" value="FERM_CS"/>
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    <dbReference type="InterPro" id="IPR000299">
        <property type="entry name" value="FERM_domain"/>
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    <dbReference type="InterPro" id="IPR018979">
        <property type="entry name" value="FERM_N"/>
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    <dbReference type="InterPro" id="IPR018980">
        <property type="entry name" value="FERM_PH-like_C"/>
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    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
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    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
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    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041783">
        <property type="entry name" value="PTPN3/4_FERM_C"/>
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    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
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        <property type="entry name" value="Tyr_Pase_cat"/>
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        <property type="entry name" value="Tyr_Pase_dom"/>
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        <property type="entry name" value="Tyr_Pase_non-rcpt_typ-3/4"/>
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    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
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    <dbReference type="PANTHER" id="PTHR45706">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
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    </dbReference>
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        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 4"/>
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    <dbReference type="Pfam" id="PF08736">
        <property type="entry name" value="FA"/>
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    <dbReference type="Pfam" id="PF09380">
        <property type="entry name" value="FERM_C"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00373">
        <property type="entry name" value="FERM_M"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FERM_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tyr-Ptase_nr3"/>
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        <property type="entry name" value="BAND41"/>
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    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
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        <property type="entry name" value="B41"/>
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    <dbReference type="SMART" id="SM01195">
        <property type="entry name" value="FA"/>
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        <property type="entry name" value="FERM_C"/>
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    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00404">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
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        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="FERM_3"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
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        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
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    </dbReference>
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    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 11" id="KW-0904">Protein phosphatase</keyword>
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        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
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        <location>
            <begin position="517"/>
            <end position="589"/>
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    </feature>
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        <location>
            <begin position="655"/>
            <end position="911"/>
        </location>
    </feature>
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        <location>
            <begin position="828"/>
            <end position="902"/>
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            <begin position="379"/>
            <end position="413"/>
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    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="468"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
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            <begin position="398"/>
            <end position="408"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="434"/>
            <end position="456"/>
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        <location>
            <position position="852"/>
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        <location>
            <position position="820"/>
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            <name>substrate</name>
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            <begin position="852"/>
            <end position="858"/>
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        <ligand>
            <name>substrate</name>
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        <location>
            <position position="896"/>
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        <ligand>
            <name>substrate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
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        <source>
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        <source>
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        <source>
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        <source>
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    <sequence length="925" mass="105844" checksum="4E96980184555E96" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="10">cAMP responsive element binding protein 1</fullName>
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        <name evidence="10" type="primary">CREB1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <property type="entry name" value="KID"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="87"/>
            <end position="146"/>
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    <feature type="domain" description="BZIP" evidence="8">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50217"/>
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            <dbReference type="PROSITE" id="PS50953"/>
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            <dbReference type="Proteomes" id="UP000694394"/>
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    <sequence length="327" mass="35136" checksum="F5BA8200EE5184B7" modified="2022-01-19" version="1">MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FLA6</accession>
    <name>A0A8B7FLA6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 12">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">UGDH</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Required for proper brain and neuronal development.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 12"/>
    <dbReference type="EMBL" id="ABDC03023178">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03023179">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609449.1">
        <property type="nucleotide sequence ID" value="XM_012753995.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7FLA6"/>
    <dbReference type="Ensembl" id="ENSMICT00000048758.2">
        <property type="protein sequence ID" value="ENSMICP00000033021.1"/>
        <property type="gene ID" value="ENSMICG00000016782.3"/>
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    <dbReference type="GeneID" id="105865426"/>
    <dbReference type="KEGG" id="mmur:105865426"/>
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    <dbReference type="GeneTree" id="ENSGT00390000015355"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
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        <property type="component" value="Chromosome 19"/>
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        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050650">
        <property type="term" value="P:chondroitin sulfate proteoglycan biosynthetic process"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:gastrulation with mouth forming second"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="Ensembl"/>
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        <property type="term" value="P:protein hexamerization"/>
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        <property type="project" value="Ensembl"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
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        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
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        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
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    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
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        <property type="entry name" value="UDPglc_DH_euk"/>
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        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
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        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
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        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
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            <begin position="11"/>
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        <ligand>
            <name>NAD(+)</name>
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        <ligand>
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    <feature type="binding site" evidence="15">
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        <ligand>
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    <feature type="binding site" evidence="14">
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        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="15">
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        <ligand>
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    <feature type="binding site" evidence="14">
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00045283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="494" mass="54954" checksum="70D4B9A085F062E8" modified="2022-01-19" version="1">MFEIKKICCIGAGYVGGPTCSVIAHMCPEVRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEHWVPRERILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDEGAHLHIYDPKVPREQIVVDLSHPGVSEDDQVSRLVTISKDPYEACDGAHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHSELQAIGFQIETIGKKVSSKRIPYAPSGEIPKFSLQDPPSKKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FMK6</accession>
    <name>A0A8B7FMK6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">LY6/PLAUR domain containing 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LYPD8</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03017150">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017151">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610024.1">
        <property type="nucleotide sequence ID" value="XM_012754570.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610025.1">
        <property type="nucleotide sequence ID" value="XM_012754571.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610027.1">
        <property type="nucleotide sequence ID" value="XM_012754573.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610028.1">
        <property type="nucleotide sequence ID" value="XM_012754574.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FMK6"/>
    <dbReference type="Ensembl" id="ENSMICT00000046381.2">
        <property type="protein sequence ID" value="ENSMICP00000018698.1"/>
        <property type="gene ID" value="ENSMICG00000029880.2"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000065120.1">
        <property type="protein sequence ID" value="ENSMICP00000043210.1"/>
        <property type="gene ID" value="ENSMICG00000029880.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105865733"/>
    <dbReference type="CTD" id="646627"/>
    <dbReference type="GeneTree" id="ENSGT00570000079564"/>
    <dbReference type="OrthoDB" id="9838086at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23568">
        <property type="entry name" value="TFP_LU_ECD_LYPD8_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23569">
        <property type="entry name" value="TFP_LU_ECD_LYPD8_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050918">
        <property type="entry name" value="CNF-like_PLA2_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016054">
        <property type="entry name" value="LY6_UPA_recep-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914">
        <property type="entry name" value="LY6/PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20914:SF2">
        <property type="entry name" value="LY6_PLAUR DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00021">
        <property type="entry name" value="UPAR_LY6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044664209" evidence="4">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="5">
        <location>
            <begin position="20"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="UPAR/Ly6" evidence="5">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="241" mass="24766" checksum="15EF9EDFDB733C4D" modified="2022-01-19" version="1">MKGILVAAVIAALAVAAVESTSCLQCHSWNNSCVDAAVFECPLSANNSCVSSTVNSSLGAAIRLYQAMSCSAENCSEETNTVMAFAVHTSDNESFHFASQCCQGGGCNSTSEDLDPPLRNVTSNIECPACYGPNETACVERIHRCYEGERCVSLVAEFTNGTASQRLALKGCSDLSDSACRALSAGNTTLGGVIFRKVECAASPATSPTTSPTTSPATSPASLASLAFLVLAGLALLGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FMS0</accession>
    <name>A0A8B7FMS0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tumor protein p53 inducible nuclear protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">TP53INP2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021616">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610122.1">
        <property type="nucleotide sequence ID" value="XM_012754668.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610123.1">
        <property type="nucleotide sequence ID" value="XM_012754669.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610124.1">
        <property type="nucleotide sequence ID" value="XM_012754670.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610125.1">
        <property type="nucleotide sequence ID" value="XM_012754671.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012610126.1">
        <property type="nucleotide sequence ID" value="XM_012754672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FMS0"/>
    <dbReference type="Ensembl" id="ENSMICT00000063693.1">
        <property type="protein sequence ID" value="ENSMICP00000042229.1"/>
        <property type="gene ID" value="ENSMICG00000042490.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105865822"/>
    <dbReference type="CTD" id="58476"/>
    <dbReference type="GeneTree" id="ENSGT00530000063829"/>
    <dbReference type="OrthoDB" id="10041339at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903828">
        <property type="term" value="P:negative regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001649">
        <property type="term" value="P:osteoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001894">
        <property type="term" value="P:tissue homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029431">
        <property type="entry name" value="TP53INP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671">
        <property type="entry name" value="DIABETES AND OBESITY REGULATED, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31671:SF2">
        <property type="entry name" value="TUMOR PROTEIN P53-INDUCIBLE NUCLEAR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14839">
        <property type="entry name" value="DOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="221" mass="24080" checksum="D6D6E564EB19AEE7" modified="2022-01-19" version="1">MFQRFTSLFFGTPPPPEDPVCPQAFVSEEDEVDGWLIIDLPDSYAAPPSPGAAPAPAGRPPPAPSLMDESWFVTPPACFTAEGPGLGPTRLQSSPLEDLLIEHPSMSVYVTGSTIVLEPGPPSPLPDAALADGDLSDGELAPARREPRALRHAAAPLPARAALLDKASQVRRLQRARQRAERHALSAKVVQRQNRARESRPRRPKHQGSFVYQPCQRQFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FUR8</accession>
    <name>A0A8B7FUR8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carabin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">TBC1 domain family member 10C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">TBC1D10C</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with both calcineurin and HRAS.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006022">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612997.1">
        <property type="nucleotide sequence ID" value="XM_012757543.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012612999.1">
        <property type="nucleotide sequence ID" value="XM_012757545.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FUR8"/>
    <dbReference type="Ensembl" id="ENSMICT00000004105.3">
        <property type="protein sequence ID" value="ENSMICP00000003741.1"/>
        <property type="gene ID" value="ENSMICG00000004107.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067741.1">
        <property type="protein sequence ID" value="ENSMICP00000049288.1"/>
        <property type="gene ID" value="ENSMICG00000004107.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105867472"/>
    <dbReference type="CTD" id="374403"/>
    <dbReference type="GeneTree" id="ENSGT00940000161287"/>
    <dbReference type="OMA" id="RPHRSSF"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031527">
        <property type="term" value="C:filopodium membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042113">
        <property type="term" value="P:B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033173">
        <property type="term" value="P:calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050869">
        <property type="term" value="P:negative regulation of B cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070885">
        <property type="term" value="P:negative regulation of calcineurin-NFAT signaling cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070373">
        <property type="term" value="P:negative regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000042">
        <property type="entry name" value="carabin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000001">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000007">
        <property type="entry name" value="TBC1 domain family member 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF4">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 10A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="7">
        <location>
            <begin position="92"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="382"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00060117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00075545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="446" mass="49648" checksum="2DB2E6FF1560A9BB" modified="2022-01-19" version="1">MAQALGEDLVQPSELQDDSSSLGSDSELSGPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTYQKLAEAPGDPQWMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRQLPRVHKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGAKVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPTQLQEEVFMSQVHGVALSERDLQREIRVQLAQLPESAPGPPPQPQARLAGAQAVFEAQQLAGARRGAKPEVPRIVVQPPEEPRPPRRKPQTRGKTFHGLLTRARGPPIEGPPRSHRGSASFLDTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FUV8</accession>
    <name>A0A8B7FUV8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TOP6B like initiator of meiotic double strand breaks</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">TOP6BL</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03006019">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03006020">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FUV8"/>
    <dbReference type="Ensembl" id="ENSMICT00000038249.2">
        <property type="protein sequence ID" value="ENSMICP00000039373.2"/>
        <property type="gene ID" value="ENSMICG00000003846.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105867460"/>
    <dbReference type="CTD" id="79703"/>
    <dbReference type="GeneTree" id="ENSGT00390000009327"/>
    <dbReference type="OrthoDB" id="9424252at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028040">
        <property type="entry name" value="TopoVIB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14652">
        <property type="entry name" value="TYPE 2 DNA TOPOISOMERASE 6 SUBUNIT B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14652:SF2">
        <property type="entry name" value="TYPE 2 DNA TOPOISOMERASE 6 SUBUNIT B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15091">
        <property type="entry name" value="DUF4554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039373.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="578" mass="63790" checksum="3BFD7DE70C4408ED" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FXZ1</accession>
    <name>A0A8B7FXZ1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rho-related GTP-binding protein Rho6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Rho family GTPase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Rnd1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">RND1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614369.1">
        <property type="nucleotide sequence ID" value="XM_012758915.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FXZ1"/>
    <dbReference type="Ensembl" id="ENSMICT00000042169.2">
        <property type="protein sequence ID" value="ENSMICP00000024662.1"/>
        <property type="gene ID" value="ENSMICG00000034995.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105868263"/>
    <dbReference type="KEGG" id="mmur:105868263"/>
    <dbReference type="CTD" id="27289"/>
    <dbReference type="GeneTree" id="ENSGT00940000158666"/>
    <dbReference type="OMA" id="PIVARCK"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005102">
        <property type="term" value="F:signaling receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007162">
        <property type="term" value="P:negative regulation of cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016322">
        <property type="term" value="P:neuron remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000569">
        <property type="entry name" value="Rho-related GTP-binding protein Rho6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0636">Prenylation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00076616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000024662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="232" mass="26055" checksum="8622759B732BE548" modified="2022-01-19" version="1">MKERRPPQPVVARCKLVLVGDVQCGKTAMLQVLAKDCYPETYVPTVFENYTACLETEEQRVELSLWDTSGSPYYDNVRPLCYSDSDAVLLCFDISRPETVDSALKKWRTEILDYCPSTRVLLIGCKTDLRTDLSTLMELSHQKQAPISYEQGCAIAKQLGAEIYLEGSAFTSEKSIHSIFRTASMVCLNKPSPMPPKSPVRSLSKRLLHLPSRSELISSTFKKEKAKSCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FY78</accession>
    <name>A0A8B7FY78_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Retinol dehydrogenase 14</fullName>
            <ecNumber evidence="2">1.1.1.300</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alcohol dehydrogenase PAN2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">RDH14</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>11-cis-retinol + NADP(+) = 11-cis-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16066"/>
            <dbReference type="ChEBI" id="CHEBI:16302"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>9-cis-retinol + NADP(+) = 9-cis-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78272"/>
            <dbReference type="ChEBI" id="CHEBI:78273"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>all-trans-retinol + NADP(+) = all-trans-retinal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25033"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17336"/>
            <dbReference type="ChEBI" id="CHEBI:17898"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.300"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.300" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03011992">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614019.1">
        <property type="nucleotide sequence ID" value="XM_012758565.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FY78"/>
    <dbReference type="Ensembl" id="ENSMICT00000034616.2">
        <property type="protein sequence ID" value="ENSMICP00000027978.1"/>
        <property type="gene ID" value="ENSMICG00000033814.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105868056"/>
    <dbReference type="KEGG" id="mmur:105868056"/>
    <dbReference type="CTD" id="57665"/>
    <dbReference type="GeneTree" id="ENSGT00940000160181"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000331">
        <property type="entry name" value="Retinol dehydrogenase 14 (All-trans/9-cis/11-cis)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF72">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="335" mass="36462" checksum="A39B5AE9006EC3D3" modified="2022-01-19" version="1">MAVATAAALLAALGGALWLAARRFVGPRVQRLHGSGTLGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRVRAEEAAGQLRRELQAGESGPDPGAGGAGELVVRELDLASLRSVRAFCQDMLQEEPRLDVLINNAGIFQCPYTKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFEDLNSEQSYDKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGITRTNLGRHIHIPPLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPKVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G876</accession>
    <name>A0A8B7G876_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled-coil domain containing 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CCDC6</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618265.1">
        <property type="nucleotide sequence ID" value="XM_012762811.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G876"/>
    <dbReference type="Ensembl" id="ENSMICT00000028959.2">
        <property type="protein sequence ID" value="ENSMICP00000020339.1"/>
        <property type="gene ID" value="ENSMICG00000031248.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105870273"/>
    <dbReference type="KEGG" id="mmur:105870273"/>
    <dbReference type="CTD" id="8030"/>
    <dbReference type="GeneTree" id="ENSGT00390000013594"/>
    <dbReference type="OrthoDB" id="78858at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="474" mass="53215" checksum="3E979EBBB4284DA0" modified="2022-01-19" version="1">MADSASESDTDGAGGNSGGSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELTNRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKIQALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKKLENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVSAPPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREENLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSPSSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSPDKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPAVPSAATSQPSPSQHSVHPSSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8D3</accession>
    <name>A0A8B7G8D3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LOC105870490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRAME family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03002347">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618576.1">
        <property type="nucleotide sequence ID" value="XM_012763122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8D3"/>
    <dbReference type="Ensembl" id="ENSMICT00000011657.3">
        <property type="protein sequence ID" value="ENSMICP00000010607.3"/>
        <property type="gene ID" value="ENSMICG00000011663.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870490"/>
    <dbReference type="KEGG" id="mmur:105870490"/>
    <dbReference type="GeneTree" id="ENSGT01030000234531"/>
    <dbReference type="OrthoDB" id="9533139at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045596">
        <property type="term" value="P:negative regulation of cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008284">
        <property type="term" value="P:positive regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000079">
        <property type="entry name" value="PRAME family member 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050694">
        <property type="entry name" value="LRRC14/PRAME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026271">
        <property type="entry name" value="PRAME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224:SF19">
        <property type="entry name" value="PRAME FAMILY MEMBER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14224">
        <property type="entry name" value="SIMILAR TO PREFERENTIALLY EXPRESSED ANTIGEN IN MELANOMA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038286">
        <property type="entry name" value="PRAME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010607.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="486" mass="55889" checksum="08E16DFF2CE5EB2B" modified="2022-01-19" version="1">MSLQAPPRLLQLAGQSLVRNEALVIPLLEELPRELFPPLFMEAFTNRCRKVLTAMVQAWPFTRLPLGALMLTPDLETLRAVLDGLDVLLALKVRPRRWKLQVLDLQDFDENFWSVGSEAVAHACLPHAMNKRKTVKNCPRMGRQQPLKVFINLHIKEGSLDELLTYLFSWVKQRKDLVHLCCTKLSIFTTQIQKIRIVLRMVDLDCIQEVNVRCSWKLSMLARFAPYLGEMRNLQKLLLLQISVYNLKKKDRFIAQFTTQFRKLDHLQRLYMNSLSFLEGHLDQVLRCLKTPLETLSITNCLLSESDLRHLSQCPSISQIKNLALSRITPTDFSPEPFQHLLEKVAATLQTLRLDECWITDPQLAVILPALSRCAQLTTFSFRGNPISKAALENLLQHTLRLSQLRLQLYDTPLESYNAGGAVSWEKLARFRAELRQILKNLWWPKRILFSTVLCPHCGHSVFYDLGLGKPCCPTPHSSRHWAAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GAT3</accession>
    <name>A0A8B7GAT3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transmembrane protein 265</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TMEM265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021375">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619657.1">
        <property type="nucleotide sequence ID" value="XM_012764203.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619658.1">
        <property type="nucleotide sequence ID" value="XM_012764204.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619659.1">
        <property type="nucleotide sequence ID" value="XM_012764205.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GAT3"/>
    <dbReference type="Ensembl" id="ENSMICT00000033130.2">
        <property type="protein sequence ID" value="ENSMICP00000032971.1"/>
        <property type="gene ID" value="ENSMICG00000026354.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871068"/>
    <dbReference type="KEGG" id="mmur:105871068"/>
    <dbReference type="CTD" id="100862671"/>
    <dbReference type="GeneTree" id="ENSGT01150000287009"/>
    <dbReference type="OrthoDB" id="9907795at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="109" mass="11930" checksum="3BF3DE25A94C36B4" modified="2022-01-19" version="1">MADEEKAVETLVGNSEAAHTPSPIRCCWLRLRYLAATSIICGCSCLGVMALVFAIKAEERLKAGRSEEAVHWGARARRLILASFAVWFAVLILGPILLWLLSYAIAQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GCF8</accession>
    <name>A0A8B7GCF8_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar ribonucleoprotein protein MPP10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MPHOSPH10</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
            <location evidence="1 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the MPP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013610">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620065.1">
        <property type="nucleotide sequence ID" value="XM_012764611.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GCF8"/>
    <dbReference type="Ensembl" id="ENSMICT00000036525.2">
        <property type="protein sequence ID" value="ENSMICP00000036312.1"/>
        <property type="gene ID" value="ENSMICG00000036069.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105871302"/>
    <dbReference type="KEGG" id="mmur:105871302"/>
    <dbReference type="CTD" id="10199"/>
    <dbReference type="GeneTree" id="ENSGT00390000011359"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017300">
        <property type="entry name" value="snoRNP_Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="363"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="558"/>
            <end position="614"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="144"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
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            <begin position="145"/>
            <end position="163"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="228"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="279"/>
            <end position="289"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
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            <begin position="290"/>
            <end position="319"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="350"/>
            <end position="363"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="558"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="671"/>
            <end position="680"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036312.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="680" mass="78864" checksum="BCE7E3959B5D71DA" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GDB6</accession>
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        <recommendedName>
            <fullName evidence="14">Granulocyte colony-stimulating factor receptor</fullName>
        </recommendedName>
    </protein>
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        <name evidence="19" type="primary">CSF3R</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <text evidence="13">Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R.</text>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type I cytokine receptor family. Type 2 subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012765190.2"/>
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        <property type="nucleotide sequence ID" value="XM_012765191.2"/>
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    <dbReference type="RefSeq" id="XP_012620646.1">
        <property type="nucleotide sequence ID" value="XM_012765192.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620647.1">
        <property type="nucleotide sequence ID" value="XM_012765193.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012620648.1">
        <property type="nucleotide sequence ID" value="XM_012765194.2"/>
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    <dbReference type="RefSeq" id="XP_012620649.1">
        <property type="nucleotide sequence ID" value="XM_012765195.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GDB6"/>
    <dbReference type="Ensembl" id="ENSMICT00000059625.1">
        <property type="protein sequence ID" value="ENSMICP00000044441.1"/>
        <property type="gene ID" value="ENSMICG00000007970.3"/>
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    <dbReference type="Ensembl" id="ENSMICT00000065067.1">
        <property type="protein sequence ID" value="ENSMICP00000050082.1"/>
        <property type="gene ID" value="ENSMICG00000007970.3"/>
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    <dbReference type="KEGG" id="mmur:105871730"/>
    <dbReference type="CTD" id="1441"/>
    <dbReference type="GeneTree" id="ENSGT00940000158915"/>
    <dbReference type="OrthoDB" id="9887129at2759"/>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0030666">
        <property type="term" value="C:endocytic vesicle membrane"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005886">
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:cytokine receptor activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Colony stimulating factor 3 receptor"/>
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        <property type="entry name" value="Colony stimulating factor 3 receptor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Colony stimulating factor 3 receptor (Granulocyte)"/>
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        <property type="entry name" value="Granulocyte colony-stimulating factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="granulocyte colony-stimulating factor receptor isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="FN3_dom"/>
    </dbReference>
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        <property type="entry name" value="FN3_sf"/>
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        <property type="entry name" value="Hematopoietin_rcpt_Gp130_CS"/>
    </dbReference>
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        <property type="entry name" value="Ig-like_dom_sf"/>
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        <property type="entry name" value="Ig-like_fold"/>
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        <property type="entry name" value="IgC2-like_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052672">
        <property type="entry name" value="Type1_Cytokine_Rcpt_Type2"/>
    </dbReference>
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        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48423:SF1">
        <property type="entry name" value="INTERLEUKIN-27 RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06328">
        <property type="entry name" value="Lep_receptor_Ig"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="4"/>
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        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="HEMATOPO_REC_L_F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
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    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044664223" description="Granulocyte colony-stimulating factor receptor" evidence="17">
        <location>
            <begin position="25"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="231"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="331"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="18">
        <location>
            <begin position="526"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008921"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="835" mass="92159" checksum="981AFCF4241B73DB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GGE1</accession>
    <name>A0A8B7GGE1_MICMU</name>
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        <recommendedName>
            <fullName evidence="20">RAS guanyl-releasing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Calcium and DAG-regulated guanine nucleotide exchange factor II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">Ras guanyl-releasing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">RASGRP1</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="21">Homodimer. Forms a signaling complex with DGKZ and HRAS. Interacts with F-actin. Interacts with SKAP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RASGRP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03004580">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621831.1">
        <property type="nucleotide sequence ID" value="XM_012766377.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GGE1"/>
    <dbReference type="Ensembl" id="ENSMICT00000040148.2">
        <property type="protein sequence ID" value="ENSMICP00000030012.2"/>
        <property type="gene ID" value="ENSMICG00000017344.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872414"/>
    <dbReference type="CTD" id="10125"/>
    <dbReference type="GeneTree" id="ENSGT00940000158910"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045321">
        <property type="term" value="P:leukocyte activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002684">
        <property type="term" value="P:positive regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20860">
        <property type="entry name" value="C1_RASGRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22290">
        <property type="entry name" value="cc_RasGRP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.870.10:FF:000008">
        <property type="entry name" value="RAS guanyl-releasing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000023">
        <property type="entry name" value="RAS guanyl-releasing protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000051">
        <property type="entry name" value="Ras guanyl-releasing protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.840.10:FF:000003">
        <property type="entry name" value="Ras guanyl-releasing protein 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF174">
        <property type="entry name" value="RAS GUANYL-RELEASING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18 25" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0221">Differentiation</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 24" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="29">
        <location>
            <begin position="52"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="27">
        <location>
            <begin position="204"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="30">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="28">
        <location>
            <begin position="540"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="25">
        <location>
            <begin position="747"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00041172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00064537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00077467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030012.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="796" mass="90458" checksum="3A2A47C95E312B26" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GJF2</accession>
    <name>A0A8B7GJF2_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Circadian associated repressor of transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">CIART</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03003006">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012622900.1">
        <property type="nucleotide sequence ID" value="XM_012767446.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GJF2"/>
    <dbReference type="Ensembl" id="ENSMICT00000015357.3">
        <property type="protein sequence ID" value="ENSMICP00000014001.1"/>
        <property type="gene ID" value="ENSMICG00000015355.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872977"/>
    <dbReference type="KEGG" id="mmur:105872977"/>
    <dbReference type="CTD" id="148523"/>
    <dbReference type="GeneTree" id="ENSGT00390000018360"/>
    <dbReference type="OMA" id="REMTVGH"/>
    <dbReference type="OrthoDB" id="9949430at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070888">
        <property type="term" value="F:E-box binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045475">
        <property type="term" value="P:locomotor rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031373">
        <property type="entry name" value="Ciart"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35441">
        <property type="entry name" value="CIRCADIAN-ASSOCIATED TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35441:SF1">
        <property type="entry name" value="CIRCADIAN-ASSOCIATED TRANSCRIPTIONAL REPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15673">
        <property type="entry name" value="Ciart"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000014001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="386" mass="41747" checksum="64AC160DF02444EF" modified="2022-01-19" version="1">MDSPSSISSYSSYSLSSSFSTSPVNSDFGFPSDSEREDKGAHGPRPDTVGQRGGSRPSPGPIRCRHRFRVSSNHHTASHPEQRGLASPMAGSGVKRSRSGELETNLNIQGCTTEGDLLFAQKCKELQGYIPPLTDLLNGLKMGRFERGLSSFQQSVAMDRIQRIVGVLQKPQMGERYLGTLLQVEGMLKTWFPHIAAQKTSLGGSRHQLTKNFPSHCSDSVASSPISPVEKMDQTQLGHVVLKPEQPWHLTEWPAMNLTWIHTTPICNPPLGSPGTISFSHGPLGSGTSIGVILFVQHGVQPFTHSTPTTPVPPTTTSPVISGDTKKLSGEGPRCYSLPVTMPSDWSCTLSPPSLPTMAREMTIGQLEQQMRSHPPGASDAHLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKE3</accession>
    <name>A0A8B7GKE3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Myocyte enhancer factor 2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF2D</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003180">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623185.1">
        <property type="nucleotide sequence ID" value="XM_012767731.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKE3"/>
    <dbReference type="Ensembl" id="ENSMICT00000032067.2">
        <property type="protein sequence ID" value="ENSMICP00000023076.1"/>
        <property type="gene ID" value="ENSMICG00000034832.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873125"/>
    <dbReference type="CTD" id="4209"/>
    <dbReference type="GeneTree" id="ENSGT00940000159463"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048513">
        <property type="term" value="P:animal organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007399">
        <property type="term" value="P:nervous system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000001">
        <property type="entry name" value="Myocyte-specific enhancer factor 2A homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022102">
        <property type="entry name" value="HJURP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF23">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12347">
        <property type="entry name" value="HJURP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0524">Neurogenesis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="9">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="350"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="429"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="513" mass="54916" checksum="27DB89A168707126" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GR94</accession>
    <name>A0A8B7GR94_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">AQP7</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>glycerol(in) = glycerol(out)</text>
            <dbReference type="Rhea" id="RHEA:29675"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014745">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625615.1">
        <property type="nucleotide sequence ID" value="XM_012770161.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625616.1">
        <property type="nucleotide sequence ID" value="XM_012770162.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GR94"/>
    <dbReference type="Ensembl" id="ENSMICT00000012970.3">
        <property type="protein sequence ID" value="ENSMICP00000011819.3"/>
        <property type="gene ID" value="ENSMICG00000012978.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874366"/>
    <dbReference type="KEGG" id="mmur:105874366"/>
    <dbReference type="CTD" id="364"/>
    <dbReference type="GeneTree" id="ENSGT00940000159054"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070295">
        <property type="term" value="P:renal water absorption"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000005">
        <property type="entry name" value="Aquaporin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF15">
        <property type="entry name" value="AQUAPORIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02019">
        <property type="entry name" value="AQUAPORIN7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="282"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011819.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="38899" checksum="0728450777040F90" modified="2022-01-19" version="1">MSQVIGQRRSTRSTRMNSSSVITSVHTTLRRQMVQEFLAECLSTYVMMVFGLGSVAHMVLGNKTFGSYLGVNLGFGFGVTMGVYIAGNISGAHMNSAVTFTSCALGRMPWKKFPVYVLGQFLGSFMAAATIYGLFYPAIIHFSSGELTVTGPTATGGIFATYLPDHMTLWRGFVDEVIVTGMLQLCLCAITDKDNPEHQGTQPLVIGFLIVIIGVGLGMNSGYAINPSRDLPPRFFTYLAGWGTQVFRAGDNWWWVPVVAPPLGAYLGGIVYLVFIGSSTSRKPKKLEDPAAYEDHRISSLPKTSHDPSMMSSLTPASVAPTTRSPVSSSFTPVSVPPIKRSSFQPAPPVRDSVNEEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GTL7</accession>
    <name>A0A8B7GTL7_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NCK interacting protein with SH3 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">NCKIPSD</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626658.1">
        <property type="nucleotide sequence ID" value="XM_012771204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GTL7"/>
    <dbReference type="Ensembl" id="ENSMICT00000049601.2">
        <property type="protein sequence ID" value="ENSMICP00000036696.1"/>
        <property type="gene ID" value="ENSMICG00000030986.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874935"/>
    <dbReference type="KEGG" id="mmur:105874935"/>
    <dbReference type="CTD" id="51517"/>
    <dbReference type="GeneTree" id="ENSGT00390000015725"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010976">
        <property type="term" value="P:positive regulation of neuron projection development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd11849">
        <property type="entry name" value="SH3_SPIN90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035514">
        <property type="entry name" value="SPIN90_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="714" mass="78130" checksum="4859839E7FCBE8FB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GUI1</accession>
    <name>A0A8B7GUI1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Protein kinase C delta type</fullName>
            <ecNumber evidence="18">2.7.11.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">nPKC-delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="primary">PRKCD</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="18">Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Cytoplasm</location>
            <location evidence="18">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="18"/>
    <dbReference type="EMBL" id="ABDC03018263">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627042.1">
        <property type="nucleotide sequence ID" value="XM_012771588.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GUI1"/>
    <dbReference type="Ensembl" id="ENSMICT00000041406.2">
        <property type="protein sequence ID" value="ENSMICP00000039014.1"/>
        <property type="gene ID" value="ENSMICG00000010903.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875067"/>
    <dbReference type="CTD" id="5580"/>
    <dbReference type="GeneTree" id="ENSGT00940000155327"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005911">
        <property type="term" value="C:cell-cell junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036019">
        <property type="term" value="C:endolysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004699">
        <property type="term" value="F:diacylglycerol-dependent, calcium-independent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043560">
        <property type="term" value="F:insulin receptor substrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030296">
        <property type="term" value="F:protein tyrosine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042100">
        <property type="term" value="P:B cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060326">
        <property type="term" value="P:cell chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904385">
        <property type="term" value="P:cellular response to angiotensin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071447">
        <property type="term" value="P:cellular response to hydroperoxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034644">
        <property type="term" value="P:cellular response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090398">
        <property type="term" value="P:cellular senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016064">
        <property type="term" value="P:immunoglobulin mediated immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030837">
        <property type="term" value="P:negative regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051490">
        <property type="term" value="P:negative regulation of filopodium assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034351">
        <property type="term" value="P:negative regulation of glial cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050728">
        <property type="term" value="P:negative regulation of inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046627">
        <property type="term" value="P:negative regulation of insulin receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090331">
        <property type="term" value="P:negative regulation of platelet aggregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042119">
        <property type="term" value="P:neutrophil activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141212">
        <property type="term" value="P:phospholipase C/protein kinase C signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001235">
        <property type="term" value="P:positive regulation of apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000304">
        <property type="term" value="P:positive regulation of ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000753">
        <property type="term" value="P:positive regulation of glucosylceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042307">
        <property type="term" value="P:positive regulation of protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000755">
        <property type="term" value="P:positive regulation of sphingomyelin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032930">
        <property type="term" value="P:positive regulation of superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070528">
        <property type="term" value="P:protein kinase C signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023021">
        <property type="term" value="P:termination of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20834">
        <property type="entry name" value="C1_nPKC_theta-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20837">
        <property type="entry name" value="C1_nPKC_theta-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase C delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000049">
        <property type="entry name" value="Protein kinase C delta type"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000008">
        <property type="entry name" value="Protein kinase C theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000020">
        <property type="entry name" value="Protein kinase C, alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000150">
        <property type="entry name" value="Protein kinase C, theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027436">
        <property type="entry name" value="PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014376">
        <property type="entry name" value="Prot_kin_PKC_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21494">
        <property type="entry name" value="PKC_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000551">
        <property type="entry name" value="PKC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF501104">
        <property type="entry name" value="Protein_kin_C_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14 18 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 18 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2" evidence="22">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="24">
        <location>
            <begin position="230"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="349"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="25">
        <location>
            <begin position="604"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="19">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="355"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20 21">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000551-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="676" mass="77432" checksum="00CC683F3485880B" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GVY6</accession>
    <name>A0A8B7GVY6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dual specificity protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
            <ecNumber evidence="9">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">DUSP7</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EC" id="3.1.3.48" evidence="9"/>
    <dbReference type="EMBL" id="ABDC03018255">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626946.1">
        <property type="nucleotide sequence ID" value="XM_012771492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GVY6"/>
    <dbReference type="Ensembl" id="ENSMICT00000031567.2">
        <property type="protein sequence ID" value="ENSMICP00000037369.1"/>
        <property type="gene ID" value="ENSMICG00000002706.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875037"/>
    <dbReference type="KEGG" id="mmur:105875037"/>
    <dbReference type="CTD" id="1849"/>
    <dbReference type="GeneTree" id="ENSGT00940000157262"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070371">
        <property type="term" value="P:ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14643">
        <property type="entry name" value="DSP_DUSP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000011">
        <property type="entry name" value="Dual specificity phosphatase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000011">
        <property type="entry name" value="Dual specificity phosphatase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008343">
        <property type="entry name" value="MKP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF305">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000939">
        <property type="entry name" value="MAPK_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01764">
        <property type="entry name" value="MAPKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="69"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="12">
        <location>
            <begin position="245"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="13">
        <location>
            <begin position="309"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="10">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="420" mass="45031" checksum="0502E1E55C692EFA" modified="2022-01-19" version="1">MKNQLCGPPARAHMSASGAAAAAGGTRAGSEPGAGCGSSAGTGASAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHAPSEQLYFSTPTNHNLFPLNTLEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H3X4</accession>
    <name>A0A8B7H3X4_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PIN2 (TERF1) interacting telomerase inhibitor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">PINX1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03023660">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630926.1">
        <property type="nucleotide sequence ID" value="XM_012775472.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7H3X4"/>
    <dbReference type="Ensembl" id="ENSMICT00000067635.1">
        <property type="protein sequence ID" value="ENSMICP00000041848.1"/>
        <property type="gene ID" value="ENSMICG00000044679.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105877159"/>
    <dbReference type="KEGG" id="mmur:105877159"/>
    <dbReference type="CTD" id="54984"/>
    <dbReference type="GeneTree" id="ENSGT00450000040279"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007080">
        <property type="term" value="P:mitotic metaphase chromosome alignment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031397">
        <property type="term" value="P:negative regulation of protein ubiquitination"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032211">
        <property type="term" value="P:negative regulation of telomere maintenance via telomerase"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904751">
        <property type="term" value="P:positive regulation of protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070198">
        <property type="term" value="P:protein localization to chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902570">
        <property type="term" value="P:protein localization to nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF27">
        <property type="entry name" value="PIN2_TERF1-INTERACTING TELOMERASE INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="332" mass="37567" checksum="AB465133E46A71A8" modified="2022-01-19" version="1">MSMLAERRRKQRWTVDPRNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIRVQVKNNHLGLGATVNNEDNWIAHQDGFNQLLAELNTCHAQETADSLDNKEKKSFSLEEKSKISKNRVHYKKFTKGKDLSSRSKTDLDCVFGKRQSKKTPEDDSSPSTPDENETTTTTTSAFTIQEYFARRMAELKSKPQVTAPRPDGSDTQAELKRRKKRNKEATGKNGESYPQPKAKQPEEETCEEEGSLERPAKKKRAPVSQQPRRALQDESSDASAEAAEDHVQPPGDQDVIPTPRKRREKQKLQKPVEEAVDMVPAETLVKKKKKKKKGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H8N7</accession>
    <name>A0A8B7H8N7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sodium/potassium-transporting ATPase subunit beta-1-interacting protein</fullName>
            <shortName evidence="7">Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NKAIN2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NKAIN family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008383">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008384">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008385">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008387">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008388">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012777552.2"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7H8N7"/>
    <dbReference type="Ensembl" id="ENSMICT00000014025.3">
        <property type="protein sequence ID" value="ENSMICP00000012785.2"/>
        <property type="gene ID" value="ENSMICG00000014034.3"/>
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    <dbReference type="GeneID" id="105878227"/>
    <dbReference type="KEGG" id="mmur:105878227"/>
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        <property type="component" value="Chromosome 6"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0002028">
        <property type="term" value="P:regulation of sodium ion transport"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="InterPro" id="IPR008516">
        <property type="entry name" value="Na/K-Atpase_Interacting"/>
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    <dbReference type="PANTHER" id="PTHR13084:SF3">
        <property type="entry name" value="SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-1-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR13084">
        <property type="entry name" value="T-CELL LYMPHOMA BREAKPOINT-ASSOCIATED TARGET 1-RELATED"/>
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    <dbReference type="Pfam" id="PF05640">
        <property type="entry name" value="NKAIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006364"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000012785.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="208" mass="23895" checksum="16F35DABE22EC2BD" modified="2022-01-19" version="1">MGYCSGRCTLIFICGMQLVCVLERQIFDFLGYQWAPILANFVHIIIVILGLFGTIQYRPRYITGYAVWLVLWVTWNVFVICFYLEAGDLSKETDLILTFNISMHRSWWMENGPGCMVTSVTPAPDWAPEDHRYITVSGCFLEYQYIEVAHSSLQIVLALAGFIYACYVVKCITEEEDSFDFIGGFDSYGYQGPQKTSHLQLQPMYMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H9D1</accession>
    <name>A0A8B7H9D1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Coiled-coil domain containing 85A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">CCDC85A</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
            <location evidence="1">Adherens junction</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCDC85 family.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03005034">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012633292.1">
        <property type="nucleotide sequence ID" value="XM_012777838.3"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7H9D1"/>
    <dbReference type="Ensembl" id="ENSMICT00000035874.2">
        <property type="protein sequence ID" value="ENSMICP00000027868.1"/>
        <property type="gene ID" value="ENSMICG00000029777.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878436"/>
    <dbReference type="KEGG" id="mmur:105878436"/>
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    <dbReference type="GeneTree" id="ENSGT00940000157361"/>
    <dbReference type="OrthoDB" id="10056395at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005912">
        <property type="term" value="C:adherens junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019359">
        <property type="entry name" value="CCDC85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546:SF13">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 85A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13546">
        <property type="entry name" value="RE60986P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10226">
        <property type="entry name" value="CCDC85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0965">Cell junction</keyword>
    <keyword evidence="4 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="136"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="591" mass="64035" checksum="AD4BFAA4BC1DDB04" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HGY6</accession>
    <name>A0A8B7HGY6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-sensitive inward rectifier potassium channel 11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Inward rectifier K(+) channel Kir6.2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Potassium channel, inwardly rectifying subfamily J member 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="primary">KCNJ11</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. In pancreatic cells, it forms KATP channels with ABCC8/SUR1. Can form cardiac and smooth muscle-type KATP channels with ABCC9.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="22">Homotetramer; the homotetramer binds four ATP molecules (one ATP per subunit). Forms an heterooctamer with ABCC8/SUR1; one KCNJ11 homotetramer interacts with four ABCC8/SUR1 molecules. Interacts with ABCC9/SUR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 24">Membrane</location>
            <topology evidence="1 24">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006344">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012636119.1">
        <property type="nucleotide sequence ID" value="XM_012780665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HGY6"/>
    <dbReference type="Ensembl" id="ENSMICT00000005515.3">
        <property type="protein sequence ID" value="ENSMICP00000005027.1"/>
        <property type="gene ID" value="ENSMICG00000005520.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879982"/>
    <dbReference type="KEGG" id="mmur:105879982"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008282">
        <property type="term" value="C:inward rectifying potassium channel"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030506">
        <property type="term" value="F:ankyrin binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015272">
        <property type="term" value="F:ATP-activated inward rectifier potassium channel activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044325">
        <property type="term" value="F:transmembrane transporter binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099508">
        <property type="term" value="F:voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046676">
        <property type="term" value="P:negative regulation of insulin secretion"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050877">
        <property type="term" value="P:nervous system process"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033198">
        <property type="term" value="P:response to ATP"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
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    </dbReference>
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        <property type="entry name" value="ATP-sensitive inward rectifier potassium channel 11"/>
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        <property type="entry name" value="G protein-activated inward rectifier potassium channel 2"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003279">
        <property type="entry name" value="K_chnl_inward-rec_Kir6.2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767:SF44">
        <property type="entry name" value="ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005465">
        <property type="entry name" value="GIRK_kir"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01332">
        <property type="entry name" value="KIR62CHANNEL"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01320">
        <property type="entry name" value="KIRCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17 24" id="KW-0407">Ion channel</keyword>
    <keyword evidence="14 24" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12 24" id="KW-0630">Potassium</keyword>
    <keyword evidence="5 24" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 24 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 24" id="KW-0813">Transport</keyword>
    <keyword evidence="11 24" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="26">
        <location>
            <begin position="36"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="27">
        <location>
            <begin position="181"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="site" description="Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesium" evidence="23">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00031412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00050001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR005465-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000005027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="390" mass="43448" checksum="D6A424061F1A8027" modified="2022-01-19" version="1">MLSRKGIIPEEYVLTRLAEDPAEPRYRARERRARFVSKKGNCNVAHKNIREQGRFLQDVFTTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPIEGAGEPCVTSINSFSSAFLFSIEVQVTIGFGGRMVTEECPLAILVLIVQNIVGLMINAIMLGCIFMKTAQAHRRAETLIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPMENGMGGNSIFLVAPLIIYHVIDANSPLYDLAPGDLHHHQDLEIIVILEGVVETTGITTQARTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDRSLLDALTLASARGPLRKRSVAVAKAKPRFSIAPDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HHR7</accession>
    <name>A0A8B7HHR7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Epithelial sodium channel subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Amiloride-sensitive sodium channel subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Beta-NaCH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Nonvoltage-gated sodium channel 1 subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">SCNEB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SCNN1B</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Apical cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635656.1">
        <property type="nucleotide sequence ID" value="XM_012780202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012635657.1">
        <property type="nucleotide sequence ID" value="XM_012780203.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HHR7"/>
    <dbReference type="Ensembl" id="ENSMICT00000029571.2">
        <property type="protein sequence ID" value="ENSMICP00000023296.1"/>
        <property type="gene ID" value="ENSMICG00000007684.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105879731"/>
    <dbReference type="KEGG" id="mmur:105879731"/>
    <dbReference type="CTD" id="6338"/>
    <dbReference type="GeneTree" id="ENSGT00940000160893"/>
    <dbReference type="OrthoDB" id="6502088at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016324">
        <property type="term" value="C:apical plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034706">
        <property type="term" value="C:sodium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015280">
        <property type="term" value="F:ligand-gated sodium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050699">
        <property type="term" value="F:WW domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050891">
        <property type="term" value="P:multicellular organismal-level water homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.470.10:FF:000003">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.770:FF:000002">
        <property type="entry name" value="Amiloride-sensitive sodium channel subunit beta 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.470.10">
        <property type="entry name" value="Acid-sensing ion channels like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.770">
        <property type="entry name" value="YojJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001873">
        <property type="entry name" value="ENaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004724">
        <property type="entry name" value="ENaC_chordates"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020903">
        <property type="entry name" value="ENaC_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00859">
        <property type="entry name" value="ENaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690:SF18">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11690">
        <property type="entry name" value="AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00858">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01078">
        <property type="entry name" value="AMINACHANNEL"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01206">
        <property type="entry name" value="ASC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="4" id="KW-0894">Sodium channel</keyword>
    <keyword evidence="12" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="586"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00050037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="634" mass="71862" checksum="3465C3260A9E24FF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HNK0</accession>
    <name>A0A8B7HNK0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">POU domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">POU2F1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with POU2AF1; the interaction increases POU2F1 transactivation activity. Interacts with NR3C1, AR, PGR and HCFC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the POU transcription factor family. Class-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003320">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639303.1">
        <property type="nucleotide sequence ID" value="XM_012783849.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HNK0"/>
    <dbReference type="Ensembl" id="ENSMICT00000011642.3">
        <property type="protein sequence ID" value="ENSMICP00000010594.3"/>
        <property type="gene ID" value="ENSMICG00000011644.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881891"/>
    <dbReference type="CTD" id="5451"/>
    <dbReference type="GeneTree" id="ENSGT00940000157831"/>
    <dbReference type="OrthoDB" id="6358449at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000979">
        <property type="term" value="F:RNA polymerase II core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000005">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000001">
        <property type="entry name" value="POU domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013847">
        <property type="entry name" value="POU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045703">
        <property type="entry name" value="POU2F1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000327">
        <property type="entry name" value="POU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050255">
        <property type="entry name" value="POU_domain_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000972">
        <property type="entry name" value="TF_octamer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636">
        <property type="entry name" value="POU DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11636:SF47">
        <property type="entry name" value="POU DOMAIN, CLASS 2, TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00157">
        <property type="entry name" value="Pou"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19536">
        <property type="entry name" value="POU2F1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00029">
        <property type="entry name" value="OCTAMER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00028">
        <property type="entry name" value="POUDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00352">
        <property type="entry name" value="POU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00035">
        <property type="entry name" value="POU_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00465">
        <property type="entry name" value="POU_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51179">
        <property type="entry name" value="POU_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="4 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 12" id="KW-0371">Homeobox</keyword>
    <keyword evidence="8 11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="POU-specific" evidence="16">
        <location>
            <begin position="303"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="15">
        <location>
            <begin position="400"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="11">
        <location>
            <begin position="402"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="516"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010594.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="766" mass="78506" checksum="F164971611CCEA46" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7HP47</accession>
    <name>A0A8B7HP47_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-C motif chemokine ligand 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">CCL16</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03019974">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638908.1">
        <property type="nucleotide sequence ID" value="XM_012783454.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7HP47"/>
    <dbReference type="Ensembl" id="ENSMICT00000044629.2">
        <property type="protein sequence ID" value="ENSMICP00000031691.1"/>
        <property type="gene ID" value="ENSMICG00000029697.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105881660"/>
    <dbReference type="KEGG" id="mmur:105881660"/>
    <dbReference type="CTD" id="6360"/>
    <dbReference type="GeneTree" id="ENSGT01100000263482"/>
    <dbReference type="OrthoDB" id="9930747at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048020">
        <property type="term" value="F:CCR chemokine receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042056">
        <property type="term" value="F:chemoattractant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008009">
        <property type="term" value="F:chemokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061844">
        <property type="term" value="P:antimicrobial humoral immune response mediated by antimicrobial peptide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070098">
        <property type="term" value="P:chemokine-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048245">
        <property type="term" value="P:eosinophil chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006954">
        <property type="term" value="P:inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030335">
        <property type="term" value="P:positive regulation of cell migration"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00272">
        <property type="entry name" value="Chemokine_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.40:FF:000034">
        <property type="entry name" value="C-C motif chemokine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039809">
        <property type="entry name" value="Chemokine_b/g/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001811">
        <property type="entry name" value="Chemokine_IL8-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036048">
        <property type="entry name" value="Interleukin_8-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015:SF21">
        <property type="entry name" value="C-C MOTIF CHEMOKINE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12015">
        <property type="entry name" value="SMALL INDUCIBLE CYTOKINE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00048">
        <property type="entry name" value="IL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00199">
        <property type="entry name" value="SCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54117">
        <property type="entry name" value="Interleukin 8-like chemokines"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0202">Cytokine</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134139" evidence="4">
        <location>
            <begin position="21"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Chemokine interleukin-8-like" evidence="5">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="119" mass="13355" checksum="E841C7B9D16B4A96" modified="2022-01-19" version="1">MKVSVAAFFLLNIILTTTAAFYSQPKIPESVNQPSACCLKYHERVLPRKLTIGYRKALNCHLPAIIFITKKNREVCSNPSKDWVQEYIKDPNLPLLPSRNSGLKTATSRKGQPQLLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7I3D5</accession>
    <name>A0A8B7I3D5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial carrier homolog 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">MTCH2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins. Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Regulates the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with p15BID.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006156">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012644106.1">
        <property type="nucleotide sequence ID" value="XM_012788652.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7I3D5"/>
    <dbReference type="Ensembl" id="ENSMICT00000043681.2">
        <property type="protein sequence ID" value="ENSMICP00000019377.1"/>
        <property type="gene ID" value="ENSMICG00000027810.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105884594"/>
    <dbReference type="KEGG" id="mmur:105884594"/>
    <dbReference type="CTD" id="23788"/>
    <dbReference type="GeneTree" id="ENSGT00390000000020"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071478">
        <property type="term" value="P:cellular response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090152">
        <property type="term" value="P:establishment of protein localization to mitochondrial membrane involved in mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061484">
        <property type="term" value="P:hematopoietic stem cell homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035701">
        <property type="term" value="P:hematopoietic stem cell migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097284">
        <property type="term" value="P:hepatocyte apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042775">
        <property type="term" value="P:mitochondrial ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010917">
        <property type="term" value="P:negative regulation of mitochondrial membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902231">
        <property type="term" value="P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000738">
        <property type="term" value="P:positive regulation of stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010635">
        <property type="term" value="P:regulation of mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902108">
        <property type="term" value="P:regulation of mitochondrial membrane permeability involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000035">
        <property type="entry name" value="Mitochondrial carrier homolog 2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10780:SF20">
        <property type="entry name" value="MITOCHONDRIAL CARRIER HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="13">
        <location>
            <begin position="118"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="303" mass="33273" checksum="0661E9DBC75A182C" modified="2022-01-19" version="1">MADAASQVLLGSGLTILSQPLMYVKVLIQVGYEPLSPTIGRNIFGRQVCQLPGLFCYAQHIASIDGKRGLFTGLTPRLCSGVLGTVVHGKVLQQCQESDKDEDLGSGNVQKEVSSCFDRVIKETTREMIARSAATLITHPFHVITLRSMVQFIGRESKYCGLCDSIVTIYREEGILGFFAGLVPRLLGDIISLWLCNSLAYLVNTYALDSGVSTMNEMKSYSQAVTGFFASMLTYPFVLVSNLMAVNNCGLAGGSPPYAPIYTSWLDCWCILQKEGNMSRGNSLFFRKVPFGKTYCCDLRMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7WYU4</accession>
    <name>A0A8B7WYU4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Inhibitor of nuclear factor kappa-B kinase subunit epsilon</fullName>
            <ecNumber evidence="3">2.7.11.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Inducible I kappa-B kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">IKBKE</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.10" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03029914">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020139970.1">
        <property type="nucleotide sequence ID" value="XM_020284381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7WYU4"/>
    <dbReference type="Ensembl" id="ENSMICT00000035365.2">
        <property type="protein sequence ID" value="ENSMICP00000027459.2"/>
        <property type="gene ID" value="ENSMICG00000010881.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000035784.2">
        <property type="protein sequence ID" value="ENSMICP00000034597.2"/>
        <property type="gene ID" value="ENSMICG00000010881.3"/>
    </dbReference>
    <dbReference type="CTD" id="9641"/>
    <dbReference type="GeneTree" id="ENSGT00950000182937"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016605">
        <property type="term" value="C:PML body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008384">
        <property type="term" value="F:IkappaB kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036435">
        <property type="term" value="F:K48-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098586">
        <property type="term" value="P:cellular response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097400">
        <property type="term" value="P:interleukin-17-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010884">
        <property type="term" value="P:positive regulation of lipid storage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032481">
        <property type="term" value="P:positive regulation of type I interferon production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043254">
        <property type="term" value="P:regulation of protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035456">
        <property type="term" value="P:response to interferon-beta"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060337">
        <property type="term" value="P:type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17128">
        <property type="entry name" value="Ubl_IKKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.420:FF:000002">
        <property type="entry name" value="Inhibitor of nuclear factor kappa B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000147">
        <property type="entry name" value="Inhibitor of nuclear factor kappa B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000100">
        <property type="entry name" value="inhibitor of nuclear factor kappa-B kinase subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000106">
        <property type="entry name" value="serine/threonine-protein kinase TBK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051180">
        <property type="entry name" value="IKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041309">
        <property type="entry name" value="TBK1_CC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041087">
        <property type="entry name" value="TBK1_ULD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969">
        <property type="entry name" value="IKB KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22969:SF10">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18394">
        <property type="entry name" value="TBK1_CCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18396">
        <property type="entry name" value="TBK1_ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="9"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071230"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00076866"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027459.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="717" mass="80425" checksum="6A7181B41AE9FE46" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UJY8</accession>
    <name>A0A8C5UJY8_MICMU</name>
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        <submittedName>
            <fullName evidence="4">Paternally expressed 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PEG10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03015486">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UJY8"/>
    <dbReference type="Ensembl" id="ENSMICT00000001465.3">
        <property type="protein sequence ID" value="ENSMICP00000001337.3"/>
        <property type="gene ID" value="ENSMICG00000001469.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183173"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000054">
        <property type="entry name" value="retrotransposon-derived protein PEG10 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA/RNA_pol_sf"/>
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        <property type="entry name" value="Retrotrans_gag_dom"/>
    </dbReference>
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        <property type="entry name" value="RTL1-rel"/>
    </dbReference>
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        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
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        <property type="entry name" value="LDOC1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15503:SF31">
        <property type="entry name" value="RETROTRANSPOSON-DERIVED PROTEIN PEG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03732">
        <property type="entry name" value="Retrotrans_gag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08284">
        <property type="entry name" value="RVP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
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        <location>
            <begin position="49"/>
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        </location>
    </feature>
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        <location>
            <begin position="79"/>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
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        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001337.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UK92</accession>
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        <submittedName>
            <fullName evidence="10">PHD finger protein 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PHF20</name>
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    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021598">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021599">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03021600">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UK92"/>
    <dbReference type="Ensembl" id="ENSMICT00000001675.3">
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        <property type="gene ID" value="ENSMICG00000001674.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156477"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000049">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000196">
        <property type="entry name" value="PHD finger protein 20 (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043449">
        <property type="entry name" value="PHF20-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022255">
        <property type="entry name" value="PHF20_AT-hook"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856:SF27">
        <property type="entry name" value="PHD FINGER PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15856">
        <property type="entry name" value="PHD FINGER PROTEIN 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20826">
        <property type="entry name" value="PHD_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12618">
        <property type="entry name" value="PHF20_AT-hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="427"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="841"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000001521.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="987" mass="112515" checksum="8B826D3FBB66FA1A" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UMU1</accession>
    <name>A0A8C5UMU1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Dynamin-1</fullName>
            <ecNumber evidence="4">3.6.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Dynamin I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="primary">DNM1</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="29" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Chromaffin granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Presynapse</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="24">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="4"/>
    <dbReference type="EMBL" id="ABDC03014911">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UMU1"/>
    <dbReference type="Ensembl" id="ENSMICT00000003425.3">
        <property type="protein sequence ID" value="ENSMICP00000003115.2"/>
        <property type="gene ID" value="ENSMICG00000003416.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155214"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042583">
        <property type="term" value="C:chromaffin granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098793">
        <property type="term" value="C:presynapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016185">
        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01256">
        <property type="entry name" value="PH_dynamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000019">
        <property type="entry name" value="Dynamin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000014">
        <property type="entry name" value="Dynamin 2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000045">
        <property type="entry name" value="dynamin-1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000555">
        <property type="entry name" value="dynamin-1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF32">
        <property type="entry name" value="DYNAMIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="17" id="KW-0168">Coated pit</keyword>
    <keyword evidence="19" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="14 24" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="13" id="KW-0944">Nitration</keyword>
    <keyword evidence="10 24" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="28">
        <location>
            <begin position="28"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="26">
        <location>
            <begin position="515"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="27">
        <location>
            <begin position="655"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="763"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="25">
        <location>
            <begin position="851"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00034106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00050873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00073713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00075371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003115.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="864" mass="97298" checksum="C205D6542F37C10F" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UPE8</accession>
    <name>A0A8C5UPE8_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear FMR1 interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NUFIP1</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03017686">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012638188.1">
        <property type="nucleotide sequence ID" value="XM_012782734.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UPE8"/>
    <dbReference type="Ensembl" id="ENSMICT00000003420.3">
        <property type="protein sequence ID" value="ENSMICP00000003110.2"/>
        <property type="gene ID" value="ENSMICG00000003419.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105881174"/>
    <dbReference type="KEGG" id="mmur:105881174"/>
    <dbReference type="CTD" id="26747"/>
    <dbReference type="GeneTree" id="ENSGT00390000003758"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005726">
        <property type="term" value="C:perichromatin fibrils"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045202">
        <property type="term" value="C:synapse"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003110.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="495" mass="56150" checksum="0A188EE01035D693" modified="2022-01-19" version="1">MAQPASGFVSPTGWLPAPELTPTLGPLSNTAQLPNTWMLWGMLPPPPPSSTPGAGSEPSSETQPRRDAQSLSGAPAPFDAQILSGAQPTFDAQSRLDSQPQVNGQSSWNFQALTSWYWRQSPNVFPQHQKSYNLPVKHSYFPQKHDAKFTAFNSPPSRKQKRKRRKEPVFHIFCDTCDRGFKNQEKYDRHMSEHIKCPEVDCSFSAHEKIVQFHWRNMHAPGMKKIKLDTPEEIARWREERRKNYPTLANIERKKKLKLEKEKRGAVLTTTQYGKMKGMSRHSQMAKIRSPGKHHRWKNGGARQRAVTGAGNHLCDSKPKGLPKAIPDPLGVLINSDSESDKEEKPQRTVVPKEVTPALCSLMSSYGNVSGSESEPEETPIKTEADILAENQVLHSNTPKSPSQDVKATVRNFSEAKCENQKKSFKQTNTKRKKDYHNYQTLFEPRTHHPYLLEMLLAPDVRHERNVILQCVRYIIKKDFFGLDTSSVKPKDVCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UQR3</accession>
    <name>A0A8C5UQR3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GON-4-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GON-4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GON4L</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A and HDAC1. Required for B cell lymphopoiesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Found in a complex with YY1, SIN3A and HDAC1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003203">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000002192.3">
        <property type="protein sequence ID" value="ENSMICP00000002007.3"/>
        <property type="gene ID" value="ENSMICG00000002183.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000016256"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030183">
        <property type="term" value="P:B cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd12202">
        <property type="entry name" value="CASP8AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000191">
        <property type="entry name" value="GON-4-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000006">
        <property type="entry name" value="GON-4-like protein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049257">
        <property type="entry name" value="Gon4l/CASP8AP2_myb-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052435">
        <property type="entry name" value="YY1-Transcr_Regul"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088:SF3">
        <property type="entry name" value="GON-4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16088">
        <property type="entry name" value="YY1 ASSOCIATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21227">
        <property type="entry name" value="Myb_DNA-binding_7"/>
        <property type="match status" value="1"/>
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                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2025-08" db="UniProtKB">
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                <consortium name="Ensembl"/>
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        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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        <text evidence="16">Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.</text>
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        <text evidence="16">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Anti-proliferative protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BTG family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009302">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012630695.1">
        <property type="nucleotide sequence ID" value="XM_012775241.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UVS7"/>
    <dbReference type="SMR" id="A0A8C5UVS7"/>
    <dbReference type="Ensembl" id="ENSMICT00000009222.3">
        <property type="protein sequence ID" value="ENSMICP00000008398.1"/>
        <property type="gene ID" value="ENSMICG00000009227.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877053"/>
    <dbReference type="KEGG" id="mmur:105877053"/>
    <dbReference type="CTD" id="694"/>
    <dbReference type="GeneTree" id="ENSGT00950000182952"/>
    <dbReference type="OMA" id="SHWFPDK"/>
    <dbReference type="OrthoDB" id="19928at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019899">
        <property type="term" value="F:enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008283">
        <property type="term" value="P:cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008285">
        <property type="term" value="P:negative regulation of cell population proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045766">
        <property type="term" value="P:positive regulation of angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045603">
        <property type="term" value="P:positive regulation of endothelial cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000271">
        <property type="term" value="P:positive regulation of fibroblast apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045663">
        <property type="term" value="P:positive regulation of myoblast differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.90:FF:000003">
        <property type="entry name" value="BTG1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.90">
        <property type="entry name" value="Anti-proliferative protein, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002087">
        <property type="entry name" value="Anti_prolifrtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033332">
        <property type="entry name" value="BTG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036054">
        <property type="entry name" value="BTG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978">
        <property type="entry name" value="B-CELL TRANSLOCATION GENE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22978:SF30">
        <property type="entry name" value="PROTEIN BTG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07742">
        <property type="entry name" value="BTG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00310">
        <property type="entry name" value="ANTIPRLFBTG1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00099">
        <property type="entry name" value="btg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160696">
        <property type="entry name" value="BTG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00960">
        <property type="entry name" value="BTG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01203">
        <property type="entry name" value="BTG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anti-proliferative protein" evidence="5">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Anti-proliferative protein" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="171" mass="19209" checksum="EFED8BE09013BE60" modified="2022-01-19" version="1">MHPFYTRAATMIGEIAAAVSFISKFLRTKGLTSERQLQTFSQSLQELLAEHYKHHWFPEKPCKGSGYRCIRINHKMDPLIGQAAQRIGLSSQELFRLLPSELTLWVDPYEVSYRIGEDGSICVLYEASPAGGSTQNSTNVQMVDSRISCKEELLLGRTSPSKNYNMMTVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UX38</accession>
    <name>A0A8C5UX38_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphatase and actin regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PHACTR2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Binds PPP1CA and actin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the phosphatase and actin regulator family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03008490">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03008491">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UX38"/>
    <dbReference type="Ensembl" id="ENSMICT00000009816.3">
        <property type="protein sequence ID" value="ENSMICP00000008938.2"/>
        <property type="gene ID" value="ENSMICG00000009825.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157628"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751:SF5">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12751">
        <property type="entry name" value="PHOSPHATASE AND ACTIN REGULATOR PHACTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="99"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="382"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU301113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008938.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="643" mass="70030" checksum="6F5F00C08E77B885" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UXQ3</accession>
    <name>A0A8C5UXQ3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">ATP-dependent RNA helicase DHX38</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">DEAH box protein 38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">DHX38</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Probable ATP-binding RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Identified in the spliceosome C complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03024116">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597984.1">
        <property type="nucleotide sequence ID" value="XM_012742530.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UXQ3"/>
    <dbReference type="Ensembl" id="ENSMICT00000011410.3">
        <property type="protein sequence ID" value="ENSMICP00000010387.1"/>
        <property type="gene ID" value="ENSMICG00000011402.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105859002"/>
    <dbReference type="KEGG" id="mmur:105859002"/>
    <dbReference type="CTD" id="9785"/>
    <dbReference type="GeneTree" id="ENSGT00940000156898"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17983">
        <property type="entry name" value="DEXHc_DHX38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000313">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004736">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="542"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="727"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="59"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1155"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="21">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="128"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1157"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1181"/>
            <end position="1194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00062997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00080917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00083364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1227" mass="140388" checksum="28ACC53E44E8C8BC" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UY09</accession>
    <name>A0A8C5UY09_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha/beta-tubulin-N-acetyltransferase 9</fullName>
            <ecNumber evidence="6">2.3.1.308</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT9</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-terminal L-methionyl-[tubulin] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[tubulin] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69607"/>
            <dbReference type="Rhea" id="RHEA-COMP:17729"/>
            <dbReference type="Rhea" id="RHEA-COMP:17730"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.308"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.308" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03019893">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UY09"/>
    <dbReference type="Ensembl" id="ENSMICT00000010544.3">
        <property type="protein sequence ID" value="ENSMICP00000009601.3"/>
        <property type="gene ID" value="ENSMICG00000010549.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000012745"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120519">
        <property type="term" value="F:tubulin N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000040">
        <property type="entry name" value="N-acetyltransferase 9 (putative)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00058998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009601.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="207" mass="23565" checksum="EDA4983B182B134B" modified="2022-01-19" version="1">MRLNQNTLLLGKKVVLVPYTSEHVPRYHEWMKSEELQRLTASEPLTLEQEYAMQHSWREDADKCTFIVLDAQKWQAQPGVTEESCMAGDVNLFLTDLEDPTVGEIEVPPITWDRRDGASSCCLPFLSSPLGGVTKLGLTKFEAKIGQGNEPSIRMFQKLHFEQVAVSSIFQEVTLRLIMNEPVQQWLLEQTSHVEEQPYRDGSAEPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZ45</accession>
    <name>A0A8C5UZ45_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="21">Cholinergic receptor nicotinic alpha 6 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="21" type="primary">CHRNA6</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>K(+)(in) = K(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29463"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Na(+)(in) = Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:34963"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Synaptic cell membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ligand-gated ion channel (TC 1.A.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03023553">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZ45"/>
    <dbReference type="Ensembl" id="ENSMICT00000010714.3">
        <property type="protein sequence ID" value="ENSMICP00000009763.3"/>
        <property type="gene ID" value="ENSMICG00000010715.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158062"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098878">
        <property type="term" value="C:neurotransmitter receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045211">
        <property type="term" value="C:postsynaptic membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022848">
        <property type="term" value="F:acetylcholine-gated monoatomic cation-selective channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19064">
        <property type="entry name" value="LGIC_TM_nAChR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.170.10:FF:000008">
        <property type="entry name" value="Cholinergic receptor nicotinic alpha 6 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.390:FF:000001">
        <property type="entry name" value="Neuronal nicotinic acetylcholine receptor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.170.10">
        <property type="entry name" value="Neurotransmitter-gated ion-channel ligand-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.390">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006202">
        <property type="entry name" value="Neur_chan_lig-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036734">
        <property type="entry name" value="Neur_chan_lig-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006201">
        <property type="entry name" value="Neur_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036719">
        <property type="entry name" value="Neuro-gated_channel_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038050">
        <property type="entry name" value="Neuro_actylchol_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006029">
        <property type="entry name" value="Neurotrans-gated_channel_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018000">
        <property type="entry name" value="Neurotransmitter_ion_chnl_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002394">
        <property type="entry name" value="Nicotinic_acetylcholine_rcpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00860">
        <property type="entry name" value="LIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18945">
        <property type="entry name" value="NEUROTRANSMITTER GATED ION CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02931">
        <property type="entry name" value="Neur_chan_LBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02932">
        <property type="entry name" value="Neur_chan_memb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00254">
        <property type="entry name" value="NICOTINICR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00252">
        <property type="entry name" value="NRIONCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90112">
        <property type="entry name" value="Neurotransmitter-gated ion-channel transmembrane pore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63712">
        <property type="entry name" value="Nicotinic receptor ligand binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00236">
        <property type="entry name" value="NEUROTR_ION_CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 18" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0770">Synapse</keyword>
    <keyword evidence="3 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 18" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034859227" evidence="18">
        <location>
            <begin position="24"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel ligand-binding" evidence="19">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="240"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Neurotransmitter-gated ion-channel transmembrane" evidence="20">
        <location>
            <begin position="397"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00036239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009763.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="440" mass="50029" checksum="9077AAE2F1396B05" modified="2022-01-19" version="1">MLPSEAVWLWFWVSAPFFKGCMGCAAEERLFQRLFSHYNQLIRPVENVSEPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPVEYDGIETLRVPAEKIWKPDIVLYNNAVGGFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMKDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYLRRLPMFYTVNLILPCLFISFLTVLVFYLPSDCREKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPGWVQKVFLQLLERLPGLTPSPAVPGSAGQAGLGAFFEKEGGCLRDRGRSPGFWSLKLALVFLFASQAEDDWKYVAMVVDRVLLWVFAAACVCGTAGLFAQPLLGGAGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5UZI3</accession>
    <name>A0A8C5UZI3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Extracellular sulfatase</fullName>
            <ecNumber evidence="12">3.1.6.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SULF2</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate.</text>
            <dbReference type="EC" id="3.1.6.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus</location>
            <location evidence="1 12">Golgi stack</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell surface</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.-" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03021834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012598426.1">
        <property type="nucleotide sequence ID" value="XM_012742972.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5UZI3"/>
    <dbReference type="Ensembl" id="ENSMICT00000006823.3">
        <property type="protein sequence ID" value="ENSMICP00000006217.2"/>
        <property type="gene ID" value="ENSMICG00000006819.3"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105859274"/>
    <dbReference type="CTD" id="55959"/>
    <dbReference type="GeneTree" id="ENSGT00940000159151"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 18"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060348">
        <property type="term" value="P:bone development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002063">
        <property type="term" value="P:chondrocyte development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048706">
        <property type="term" value="P:embryonic skeletal system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0014846">
        <property type="term" value="P:esophagus smooth muscle contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035860">
        <property type="term" value="P:glial cell-derived neurotrophic factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032836">
        <property type="term" value="P:glomerular basement membrane development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003094">
        <property type="term" value="P:glomerular filtration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030201">
        <property type="term" value="P:heparan sulfate proteoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060384">
        <property type="term" value="P:innervation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097421">
        <property type="term" value="P:liver regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040037">
        <property type="term" value="P:negative regulation of fibroblast growth factor receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090263">
        <property type="term" value="P:positive regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010575">
        <property type="term" value="P:positive regulation of vascular endothelial growth factor production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000345">
        <property type="term" value="P:regulation of hepatocyte proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000003">
        <property type="entry name" value="Extracellular sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014615">
        <property type="entry name" value="Extracellular_sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024609">
        <property type="entry name" value="Extracellular_sulfatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF4">
        <property type="entry name" value="EXTRACELLULAR SULFATASE SULF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12548">
        <property type="entry name" value="DUF3740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036665">
        <property type="entry name" value="Sulf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044049723" description="Extracellular sulfatase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="18">
        <location>
            <begin position="44"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Extracellular sulfatase C-terminal" evidence="19">
        <location>
            <begin position="528"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via 3-oxoalanine" evidence="15">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="13">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036665-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF12548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000006217.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="870" mass="100181" checksum="27486E85DD12FE91" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V332</accession>
    <name>A0A8C5V332_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Asialoglycoprotein receptor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ASGR2</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03020562">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632570.1">
        <property type="nucleotide sequence ID" value="XM_012777116.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012632579.1">
        <property type="nucleotide sequence ID" value="XM_012777125.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V332"/>
    <dbReference type="Ensembl" id="ENSMICT00000012092.3">
        <property type="protein sequence ID" value="ENSMICP00000011008.2"/>
        <property type="gene ID" value="ENSMICG00000012091.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000067481.1">
        <property type="protein sequence ID" value="ENSMICP00000046723.1"/>
        <property type="gene ID" value="ENSMICG00000012091.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877990"/>
    <dbReference type="KEGG" id="mmur:105877990"/>
    <dbReference type="CTD" id="433"/>
    <dbReference type="GeneTree" id="ENSGT00940000162310"/>
    <dbReference type="OrthoDB" id="2142683at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000041">
        <property type="entry name" value="Asialoglycoprotein receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03954">
        <property type="entry name" value="Lectin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="11">
        <location>
            <begin position="181"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000011008.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="308" mass="34836" checksum="F7AA04439D656DEC" modified="2022-01-19" version="1">MAKDSQDIQQLDLEENDHQPQLGRSEGPGTCRQTPGGEDLLWKGPPAPQCFAQRLCSMLRLSLLVLGFNVLLLVAICVIGSQSTQMRLELRALKETFSNFSSSTIAEVRALGAHGGSVVGKLTSLGAKLEKQQQDLKADHATLLLHLKHFPADLRVLSCQMEVLYSNGSERTCCPVNWVEHAGSCYWFSRSGKPWLEAEKYCQLENSHLVVINSWEEQKFIAQHTSPFNAWIGLTDSDGSWKWVDGTEYRHNYKNWAITQPDNWEGHELDGGEDCAEMQPNGRWNDNFCLQVFRWVCEKKRNSTLQEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V3F5</accession>
    <name>A0A8C5V3F5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Paladin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PALD1</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the paladin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018941">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618065.1">
        <property type="nucleotide sequence ID" value="XM_012762611.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V3F5"/>
    <dbReference type="Ensembl" id="ENSMICT00000015093.3">
        <property type="protein sequence ID" value="ENSMICP00000013764.2"/>
        <property type="gene ID" value="ENSMICG00000015086.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870193"/>
    <dbReference type="KEGG" id="mmur:105870193"/>
    <dbReference type="CTD" id="27143"/>
    <dbReference type="GeneTree" id="ENSGT00390000005448"/>
    <dbReference type="OrthoDB" id="66369at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17659">
        <property type="entry name" value="PTP_paladin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000091">
        <property type="entry name" value="Phosphatase domain containing paladin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14566">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01301">
        <property type="entry name" value="PTPlike_phytase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0519">Myristate</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013764.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="854" mass="95689" checksum="C8BD571469D57961" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V549</accession>
    <name>A0A8C5V549_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">EIF4A1</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ABDC03020552">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012631636.1">
        <property type="nucleotide sequence ID" value="XM_012776182.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V549"/>
    <dbReference type="SMR" id="A0A8C5V549"/>
    <dbReference type="Ensembl" id="ENSMICT00000014757.3">
        <property type="protein sequence ID" value="ENSMICP00000013457.3"/>
        <property type="gene ID" value="ENSMICG00000014759.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105877539"/>
    <dbReference type="KEGG" id="mmur:105877539"/>
    <dbReference type="CTD" id="1973"/>
    <dbReference type="GeneTree" id="ENSGT00940000153889"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097165">
        <property type="term" value="C:nuclear stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="63"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="245"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013457.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="406" mass="46154" checksum="6EF89939F3045420" modified="2022-01-19" version="1">MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5V637</accession>
    <name>A0A8C5V637_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="14">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">CYB5R1</name>
        <name evidence="16" type="synonym">LOC105860018</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03029854">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5V637"/>
    <dbReference type="Ensembl" id="ENSMICT00000037218.2">
        <property type="protein sequence ID" value="ENSMICP00000016403.1"/>
        <property type="gene ID" value="ENSMICG00000034721.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860018"/>
    <dbReference type="KEGG" id="mmur:105860018"/>
    <dbReference type="GeneTree" id="ENSGT00940000160784"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000021">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000005">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF74">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0520">NAD</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="44"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="305" mass="33895" checksum="50BCB363986F3847" modified="2022-01-19" version="1">MGVQPSSALLASLGVGLLTLLGLALGSYLLRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHILGLPVGKHIYLSARIDGSLVIRPYTPVTSDEDQGYVDLVIKIYLKGVHPKFPEGGKMSQYLNSLKIGDVVEFRGPSGLLTYAGKGQFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIQAILKVPEDPTQCFLLFANQTEKDIILREDLEELQAQHPTRFKLWFTLDHPPADWAYSKGFVTADLIREHLPAPGDDVLLLLCGPPPMVQLACHPNLDKLGYSQKMRFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VAI0</accession>
    <name>A0A8C5VAI0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylate kinase 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + AMP = GDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:29863"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034400">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VAI0"/>
    <dbReference type="Ensembl" id="ENSMICT00000037465.2">
        <property type="protein sequence ID" value="ENSMICP00000019057.1"/>
        <property type="gene ID" value="ENSMICG00000026999.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000155120"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="8">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="191" mass="21642" checksum="22CB7811F1795B69" modified="2022-01-19" version="1">HFELKHLSSGDLLRDNMLRGTEIGVLAKAFIDQGKLIPDDVMTRLALHELKNLTQHSWLLDGFPRTLPQVEALDKVHQIDTVINLNVPFEVIKQRLTACWIHPASGRVYNIEFNPPKTMGIDDVTGEPLVQPEDDRPETVIKRLKAYEAQTKKKGVLETFSGTETNKIWPHVYAFLQTKVPQTNQKASVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VB12</accession>
    <name>A0A8C5VB12_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bcl-2-related protein A1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Hemopoietic-specific early response protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Protein BFL-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">BCL2A1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection. Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Bcl-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03013786">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VB12"/>
    <dbReference type="Ensembl" id="ENSMICT00000043327.2">
        <property type="protein sequence ID" value="ENSMICP00000016746.1"/>
        <property type="gene ID" value="ENSMICG00000032100.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01130000278292"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051400">
        <property type="term" value="F:BH domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097192">
        <property type="term" value="P:extrinsic apoptotic signaling pathway in absence of ligand"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008630">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to DNA damage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001836">
        <property type="term" value="P:release of cytochrome c from mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06845">
        <property type="entry name" value="Bcl-2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.437.10:FF:000008">
        <property type="entry name" value="Bcl-2-related protein A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.437.10">
        <property type="entry name" value="Blc2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036834">
        <property type="entry name" value="Bcl-2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046371">
        <property type="entry name" value="Bcl-2_BH1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026298">
        <property type="entry name" value="Bcl-2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020717">
        <property type="entry name" value="Bcl2_BH1_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020726">
        <property type="entry name" value="Bcl2_BH2_motif_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013282">
        <property type="entry name" value="Bcl2A1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256">
        <property type="entry name" value="BCL-2 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11256:SF10">
        <property type="entry name" value="BCL-2-RELATED PROTEIN A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00452">
        <property type="entry name" value="Bcl-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01862">
        <property type="entry name" value="BCL2FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01867">
        <property type="entry name" value="BCL2RLATEDA1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00337">
        <property type="entry name" value="BCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56854">
        <property type="entry name" value="Bcl-2 inhibitors of programmed cell death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01080">
        <property type="entry name" value="BH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01258">
        <property type="entry name" value="BH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bcl-2 Bcl-2 homology region 1-3" evidence="9">
        <location>
            <begin position="50"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000016746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="186" mass="20928" checksum="890EDA8BBFDE4504" modified="2022-01-19" version="1">MKQLQTLLPAGRKMTGCEFEFTRELAQDYLQHVLRAPQPGSSPSEASRVLRSVASSVQNEVERRLEPCLDNFNVASVETARAIFSRVMEQEFGDGVVNWGRVVTVFAFGGVLTKRLLRERAALDPDACKQISHLIAEFVVSHTGEWIRQNGGWEHGFVKKFEPRPAWLTFLEVLGKVCGVLSLLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VGA5</accession>
    <name>A0A8C5VGA5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-hydroxyacyl-CoA lyase 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Acetolactate synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">IlvB-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="primary">ILVBL</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="25" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="25" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Endoplasmic reticulum 2-OH acyl-CoA lyase involved in the cleavage (C1 removal) reaction in the fatty acid alpha-oxydation in a thiamine pyrophosphate (TPP)-dependent manner. Involved in the phytosphingosine degradation pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2R)-hydroxyhexadecanoyl-CoA = pentadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55212"/>
            <dbReference type="ChEBI" id="CHEBI:17302"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:138654"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:55213"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2-hydroxyoctadecanoyl-CoA = heptadecanal + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:55196"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:74116"/>
            <dbReference type="ChEBI" id="CHEBI:138631"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:55197"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030164">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VGA5"/>
    <dbReference type="Ensembl" id="ENSMICT00000005896.3">
        <property type="protein sequence ID" value="ENSMICP00000005380.2"/>
        <property type="gene ID" value="ENSMICG00000005896.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000033526.2">
        <property type="protein sequence ID" value="ENSMICP00000022543.1"/>
        <property type="gene ID" value="ENSMICG00000005896.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158035"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000021">
        <property type="entry name" value="IlvB (bacterial acetolactate synthase)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000048">
        <property type="entry name" value="IlvB (bacterial acetolactate synthase)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000043">
        <property type="entry name" value="IlvB acetolactate synthase like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF166">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 21" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="24">
        <location>
            <begin position="53"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="22">
        <location>
            <begin position="273"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="23">
        <location>
            <begin position="467"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00056367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000022543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="632" mass="68132" checksum="D176C6AFEB030BFB" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VH83</accession>
    <name>A0A8C5VH83_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lysophospholipase</fullName>
            <ecNumber evidence="3">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">PNPLA6</name>
        <name evidence="22" type="synonym">MCOLN1</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + (9Z)-octadecenoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28610"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:40808"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1-hexadecanoyl-sn-glycero-3-phosphate + H2O = sn-glycerol 3-phosphate + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49092"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57518"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:49093"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40435"/>
            <dbReference type="ChEBI" id="CHEBI:7896"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:72998"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:40436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:15178"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03027852">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000033080.2">
        <property type="protein sequence ID" value="ENSMICP00000020539.2"/>
        <property type="gene ID" value="ENSMICG00000003776.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000159130"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009887">
        <property type="term" value="P:animal organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd07225">
        <property type="entry name" value="Pat_PNPLA6_PNPLA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000010">
        <property type="entry name" value="neuropathy target esterase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000012">
        <property type="entry name" value="neuropathy target esterase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000001">
        <property type="entry name" value="neuropathy target esterase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000022">
        <property type="entry name" value="Patatin like phospholipase domain containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF26">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 17" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="186"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="502"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="20">
        <location>
            <begin position="635"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="21">
        <location>
            <begin position="971"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1296"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="17">
        <location>
            <begin position="975"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="1303"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="1004"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="17">
        <location>
            <position position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048454"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020539.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1365" mass="150087" checksum="14615363942976CF" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VKL0</accession>
    <name>A0A8C5VKL0_MICMU</name>
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        <submittedName>
            <fullName evidence="4">Transmembrane protein 94</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">TMEM94</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03019879">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="ABDC03019880">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_012778804.2"/>
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    <dbReference type="Ensembl" id="ENSMICT00000043610.2">
        <property type="protein sequence ID" value="ENSMICP00000025063.2"/>
        <property type="gene ID" value="ENSMICG00000007421.3"/>
    </dbReference>
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    <dbReference type="GeneTree" id="ENSGT00390000016550"/>
    <dbReference type="OrthoDB" id="5568754at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039720">
        <property type="entry name" value="TMEM94"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13219:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1124"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1167"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1235"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1264"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025063.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1356" mass="151339" checksum="288FD97CFB8055A5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VM48</accession>
    <name>A0A8C5VM48_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ankyrin repeat domain-containing protein 23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Diabetes-related ankyrin repeat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ANKRD23</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with titin/TTN and MYPN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03005351">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012642404.1">
        <property type="nucleotide sequence ID" value="XM_012786950.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VM48"/>
    <dbReference type="Ensembl" id="ENSMICT00000051495.2">
        <property type="protein sequence ID" value="ENSMICP00000023853.1"/>
        <property type="gene ID" value="ENSMICG00000012604.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105883653"/>
    <dbReference type="KEGG" id="mmur:105883653"/>
    <dbReference type="CTD" id="200539"/>
    <dbReference type="GeneTree" id="ENSGT00940000161920"/>
    <dbReference type="OMA" id="AGPWWES"/>
    <dbReference type="OrthoDB" id="9995210at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031674">
        <property type="term" value="C:I band"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031432">
        <property type="term" value="F:titin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060297">
        <property type="term" value="P:regulation of sarcomere organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035994">
        <property type="term" value="P:response to muscle stretch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000413">
        <property type="entry name" value="Ankyrin repeat domain 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000093">
        <property type="entry name" value="ankyrin repeat domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050663">
        <property type="entry name" value="Ankyrin-SOCS_Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193:SF122">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24193">
        <property type="entry name" value="ANKYRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="144"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00082248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="306" mass="34484" checksum="47D3A5B07A44D812" modified="2022-01-19" version="1">MDFISIQQLVCGERMERKVLGFGHGVPDPGGWPSDGRMAPQEALAREKLKLEEEKKKKLERFNSSRLNLETLADLENLVQRRREKRLRRRVPPRESEPVVKLQPQAQVESVDLEMFLKAAAENQEALIDKYLADGGNPNAHDKLHRTALHWACLKGHSQLVNKLLAAGATVDPRDLLDRTPMFWACRGGHLDILKQLLNQGARVNARDKIWSTPLHVAVRTGHSDCLEHLIECGAHINAQDKEGDTALHEAVRHGRFKAMKLLLLYGAKLGVQNVASMTPVQLARDWQRGIQEALQAHVAHPRTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VMC2</accession>
    <name>A0A8C5VMC2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="13">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the chaperonin-containing T-complex (TRiC), a hexadecamer composed of two identical back-to-back stacked rings enclosing a protein folding chamber. Each ring is made up of eight different subunits: TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A/CCT6, CCT7, CCT8. Interacts with PACRG. Interacts with DLEC1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03012247">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VMC2"/>
    <dbReference type="Ensembl" id="ENSMICT00000034072.2">
        <property type="protein sequence ID" value="ENSMICP00000023452.2"/>
        <property type="gene ID" value="ENSMICG00000032327.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074832"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000023452.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="551" mass="59867" checksum="79E11493258130C5" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VNA7</accession>
    <name>A0A8C5VNA7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein NLRC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NLRC5</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with RIGI and IFIH1; blocks the interaction of MAVS to RIGI.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NLRP family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024261">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000049268.2">
        <property type="protein sequence ID" value="ENSMICP00000026609.2"/>
        <property type="gene ID" value="ENSMICG00000011036.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000160652"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060339">
        <property type="term" value="P:negative regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045345">
        <property type="term" value="P:positive regulation of MHC class I biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045348">
        <property type="term" value="P:positive regulation of MHC class II biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060340">
        <property type="term" value="P:positive regulation of type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060335">
        <property type="term" value="P:positive regulation of type II interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.533.20:FF:000001">
        <property type="entry name" value="NLR family CARD domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001114">
        <property type="entry name" value="NLR family CARD domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000255">
        <property type="entry name" value="NLR family CARD domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000267">
        <property type="entry name" value="NLR family CARD domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000508">
        <property type="entry name" value="NLR family CARD domain containing 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.533.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041210">
        <property type="entry name" value="NLRC5_atypical_Card"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041267">
        <property type="entry name" value="NLRP_HD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47189">
        <property type="entry name" value="MHC CLASS II TRANSACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47189:SF1">
        <property type="entry name" value="MHC CLASS II TRANSACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18461">
        <property type="entry name" value="Atypical_Card"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17776">
        <property type="entry name" value="NLRC4_HD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0391">Immunity</keyword>
    <keyword evidence="4" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="14">
        <location>
            <begin position="225"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="99"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026609.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1871" mass="202689" checksum="EEA99F67E6806CE7" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VWP1</accession>
    <name>A0A8C5VWP1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="27">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="30" type="primary">DLD</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="30" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="30" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22 27">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="25 27">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="25 27">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="23">Homodimer. Part of the multimeric pyruvate dehydrogenase complex that contains multiple copies of pyruvate dehydrogenase (subunits PDHA (PDHA1 or PDHA2) and PDHB, E1), dihydrolipoamide acetyltransferase (DLAT, E2) and lipoamide dehydrogenase (DLD, E3). These subunits are bound to an inner core composed of about 48 DLAT and 12 PDHX molecules (by non covalent bonds). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2), DLD (dihydrolipoamide dehydrogenase; E3) and the assembly factor KGD4. It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A. Interacts with PDHX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell projection</location>
            <location evidence="3">Cilium</location>
            <location evidence="3">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Secretory vesicle</location>
            <location evidence="2">Acrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="27">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 27">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="27"/>
    <dbReference type="EMBL" id="ABDC03015355">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012601493.1">
        <property type="nucleotide sequence ID" value="XM_012746039.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VWP1"/>
    <dbReference type="Ensembl" id="ENSMICT00000045165.2">
        <property type="protein sequence ID" value="ENSMICP00000030545.1"/>
        <property type="gene ID" value="ENSMICG00000036659.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105860915"/>
    <dbReference type="KEGG" id="mmur:105860915"/>
    <dbReference type="CTD" id="1738"/>
    <dbReference type="GeneTree" id="ENSGT00550000074844"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001669">
        <property type="term" value="C:acrosomal vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000221">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="18" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="20" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 25 27" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 27" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13 25 27" id="KW-0520">NAD</keyword>
    <keyword evidence="25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12 27" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19 27" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="29">
        <location>
            <begin position="43"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="28">
        <location>
            <begin position="389"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="24">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="220"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <begin position="361"/>
            <end position="364"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="26">
        <location>
            <begin position="80"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00062615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000030545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="509" mass="54184" checksum="104B6947A83FA173" modified="2022-01-19" version="1">MQSWSRVYCSLAKRGHFNRISHGLQGLSAVPLRSYADQSIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLGKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGNTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGIGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTQNLGLEQLGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGHKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKPINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5VZS6</accession>
    <name>A0A8C5VZS6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pulmonary surfactant-associated protein D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Lung surfactant protein D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">SFTPD</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="17">Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex of 4 set of homotrimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Surface film</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SFTPD family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018966">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617946.1">
        <property type="nucleotide sequence ID" value="XM_012762492.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5VZS6"/>
    <dbReference type="Ensembl" id="ENSMICT00000041570.2">
        <property type="protein sequence ID" value="ENSMICP00000032343.2"/>
        <property type="gene ID" value="ENSMICG00000030174.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105870136"/>
    <dbReference type="CTD" id="6441"/>
    <dbReference type="GeneTree" id="ENSGT00940000155748"/>
    <dbReference type="OrthoDB" id="10255512at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005581">
        <property type="term" value="C:collagen trimer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048286">
        <property type="term" value="P:lung alveolus development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002682">
        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007585">
        <property type="term" value="P:respiratory gaseous exchange by respiratory system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043129">
        <property type="term" value="P:surfactant homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03591">
        <property type="entry name" value="CLECT_collectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.360:FF:000001">
        <property type="entry name" value="Pulmonary surfactant-associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000045">
        <property type="entry name" value="Pulmonary surfactant-associated protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.360">
        <property type="entry name" value="SFTPD helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018378">
        <property type="entry name" value="C-type_lectin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051077">
        <property type="entry name" value="Ca-dependent_lectin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033990">
        <property type="entry name" value="Collectin_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015097">
        <property type="entry name" value="Surfac_D-trimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24024:SF15">
        <property type="entry name" value="PULMONARY SURFACTANT-ASSOCIATED PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09006">
        <property type="entry name" value="Surfac_D-trimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57944">
        <property type="entry name" value="Triple coiled coil domain of C-type lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00615">
        <property type="entry name" value="C_TYPE_LECTIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0176">Collagen</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0305">Gaseous exchange</keyword>
    <keyword evidence="16" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="13" id="KW-0391">Immunity</keyword>
    <keyword evidence="6" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0767">Surface film</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044150182" description="Pulmonary surfactant-associated protein D" evidence="21">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="22">
        <location>
            <begin position="271"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="42"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00054961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00070848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00083470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032343.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="374" mass="37833" checksum="85E81AD61F441ECC" modified="2022-01-19" version="1">MLLLLSVLVLLTQPLGYLEAEMKTYSRRTVADACTLVMCSSVENGLPGRDGRDGREGPRGEKGDPGLPGAVGQAGMPGPAGAIGPKGDNGSAGEPGPKGDTGPSGPPGLPGVPGPAGTEGVQGRQGNVGPQGKPGPKGEAGPKGEVGAPGMQGSAGTRGPTGPKGERGAPGERGAPGNAGAAGPAGAVGAQGAPGARGPPGLKGDRGVPGDRGAKGESGLPEVTALRQQVEALQGQLRHLQATFSQYKKVELFPNGRSVGKKIFKTVGLEKPFEHAQQVCVQAGGQLASPRSEAENAALQQLVTDQNKAAFLSMTDTKTEGKFTYPTGEPLVYSNWAPGEPNNDGGAENCVEIFTNGKWNDRACAEQRLVICEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0J1</accession>
    <name>A0A8C5W0J1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Zinc finger protein 404</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ZNF404</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03026724">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616779.1">
        <property type="nucleotide sequence ID" value="XM_012761325.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W0J1"/>
    <dbReference type="Ensembl" id="ENSMICT00000031668.2">
        <property type="protein sequence ID" value="ENSMICP00000034277.2"/>
        <property type="gene ID" value="ENSMICG00000032342.2"/>
    </dbReference>
    <dbReference type="KEGG" id="mmur:105869485"/>
    <dbReference type="CTD" id="342908"/>
    <dbReference type="GeneTree" id="ENSGT00940000164159"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
        <property type="entry name" value="KRAB_A-box"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AGAP008430-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000008">
        <property type="entry name" value="RB-associated KRAB zinc finger protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000020">
        <property type="entry name" value="Zinc finger protein 14 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000053">
        <property type="entry name" value="zinc finger protein 182 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000295">
        <property type="entry name" value="zinc finger protein 19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000058">
        <property type="entry name" value="Zinc finger protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000087">
        <property type="entry name" value="Zinc finger protein 354B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001498">
        <property type="entry name" value="Zinc finger protein 404"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002390">
        <property type="entry name" value="zinc finger protein 404 isoform X2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000773">
        <property type="entry name" value="Zinc finger protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000737">
        <property type="entry name" value="Zinc finger protein 565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000051">
        <property type="entry name" value="zinc finger protein 585A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000416">
        <property type="entry name" value="zinc finger protein 879 isoform X1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001909">
        <property type="entry name" value="KRAB"/>
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    <dbReference type="InterPro" id="IPR036051">
        <property type="entry name" value="KRAB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050826">
        <property type="entry name" value="Krueppel_C2H2_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24377">
        <property type="entry name" value="IP01015P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01352">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00349">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50805">
        <property type="entry name" value="KRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="15"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="14">
        <location>
            <begin position="63"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="384"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="440"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="468"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="496"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="552"/>
            <end position="579"/>
        </location>
    </feature>
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        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50805"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034277.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="609" mass="70969" checksum="CAB95CC858D15821" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W0Q7</accession>
    <name>A0A8C5W0Q7_MICMU</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
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    <reference evidence="1" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03004575">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W0Q7"/>
    <dbReference type="Ensembl" id="ENSMICT00000040516.2">
        <property type="protein sequence ID" value="ENSMICP00000034401.1"/>
        <property type="gene ID" value="ENSMICG00000029270.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00860000136167"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000034401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="121" mass="12605" checksum="0C1F6ABBF7572E33" modified="2022-01-19" version="1">MWLAVRSHMGEGVEEWVRLEGAFSLGCEQLCAGGFAAGGGGSLPGLVLSPGPVWVWDWPPPFAPAPTPAVRGFSSLPCLLRGGARGSLGVSMTTLCVWEGQTWGLPARGPFLGDHLSMSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W222</accession>
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        <submittedName>
            <fullName evidence="13">Limb development membrane protein 1 like</fullName>
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    </protein>
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        <name evidence="13" type="primary">LMBR1L</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LIMR family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009651">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616741.1">
        <property type="nucleotide sequence ID" value="XM_012761287.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W222"/>
    <dbReference type="Ensembl" id="ENSMICT00000043596.2">
        <property type="protein sequence ID" value="ENSMICP00000035095.2"/>
        <property type="gene ID" value="ENSMICG00000017550.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869476"/>
    <dbReference type="KEGG" id="mmur:105869476"/>
    <dbReference type="CTD" id="55716"/>
    <dbReference type="GeneTree" id="ENSGT00390000007809"/>
    <dbReference type="OrthoDB" id="5596951at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060218">
        <property type="term" value="P:hematopoietic stem cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090090">
        <property type="term" value="P:negative regulation of canonical Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070231">
        <property type="term" value="P:T cell apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030217">
        <property type="term" value="P:T cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042098">
        <property type="term" value="P:T cell proliferation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008075">
        <property type="entry name" value="LIMR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625">
        <property type="entry name" value="LIPOCALIN-1 INTERACTING MEMBRANE RECEPTOR LIMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12625:SF2">
        <property type="entry name" value="PROTEIN LMBR1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01692">
        <property type="entry name" value="LIPOCALINIMR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="297"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035095.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="489" mass="55082" checksum="0C6D4AB30BD724CB" modified="2022-01-19" version="1">MEAADYEVLSVREQLFHERVRECIISTLLFAALYILCHIFLTRFKKPAEFTTVDDEDATVNKIALELCTFTLAVALGAVLLLPFSIISNEVLLSLPRNYYIQWLNGSLIHGLWNLVFLFSNLSLIFLMPFAYFFTESEGFAGSRKGVLGRVYETVVMLMLLTLLVLGMVWVASAIVDNNKASRESLYDFWEYYLPYLYSCISFLGVLLLLVCTPLGLARMFSVTGKLLVKPRLLEDLEEQLYCSAFEEAALTRRICNPTSCWLPLDMELLHRQVLALQTQRVLLEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAIHILELLIDEAAMPRGMQGASLGQVSFSKLGSFGAVIQVVLIFYLMVSSVVGFYSSPLFRSLRPRWHDTAMTQIIGNCVCLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLCLVKTFTAAVRAELIRAFGLDRLPLPVSGFPRASRKTQHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W473</accession>
    <name>A0A8C5W473_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 18">Calpain-3</fullName>
            <ecNumber evidence="13 18">3.4.22.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">CAPN3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Calcium-regulated non-lysosomal thiol-protease.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 18">
            <text>Broad endopeptidase activity.</text>
            <dbReference type="EC" id="3.4.22.54"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer; via EF-hand domain 4. Interacts with TTN/titin. Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with SIMC1. Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the peptidase C2 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.54" evidence="13 18"/>
    <dbReference type="EMBL" id="ABDC03004633">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004634">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03004635">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W473"/>
    <dbReference type="Ensembl" id="ENSMICT00000031118.2">
        <property type="protein sequence ID" value="ENSMICP00000033503.1"/>
        <property type="gene ID" value="ENSMICG00000027351.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000156092"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00214">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00044">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16190">
        <property type="entry name" value="EFh_PEF_CAPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000555">
        <property type="entry name" value="Calpain-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000065">
        <property type="entry name" value="calpain-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.380:FF:000002">
        <property type="entry name" value="calpain-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033883">
        <property type="entry name" value="C2_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022684">
        <property type="entry name" value="Calpain_cysteine_protease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022682">
        <property type="entry name" value="Calpain_domain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022683">
        <property type="entry name" value="Calpain_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036213">
        <property type="entry name" value="Calpain_III_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032100">
        <property type="entry name" value="Calpain_u2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054069">
        <property type="entry name" value="CAPN3/13-like_C_EFh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029531">
        <property type="entry name" value="CAPN3_PEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183">
        <property type="entry name" value="CALPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10183:SF329">
        <property type="entry name" value="CALPAIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01067">
        <property type="entry name" value="Calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16648">
        <property type="entry name" value="Calpain_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21875">
        <property type="entry name" value="CAPN13-like_C_EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00704">
        <property type="entry name" value="CALPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00720">
        <property type="entry name" value="calpain_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49758">
        <property type="entry name" value="Calpain large subunit, middle domain (domain III)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 18" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 17 18" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17 18" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="20">
        <location>
            <begin position="74"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="21">
        <location>
            <begin position="781"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="605"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 17">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 17">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="active site" evidence="16 17">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR622684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="815" mass="93725" checksum="56BCF3C6D0C994E0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W500</accession>
    <name>A0A8C5W500_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Syntaxin-12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">STX12</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="15">SNARE promoting fusion of transport vesicles with target membranes. Together with SNARE STX6, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway. Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Early endosome membrane</location>
            <topology evidence="13">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endomembrane system</location>
            <topology evidence="16">Single-pass type IV membrane protein</topology>
            <orientation evidence="16">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Recycling endosome membrane</location>
            <topology evidence="14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001800">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606167.1">
        <property type="nucleotide sequence ID" value="XM_012750713.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W500"/>
    <dbReference type="Ensembl" id="ENSMICT00000035607.2">
        <property type="protein sequence ID" value="ENSMICP00000033947.2"/>
        <property type="gene ID" value="ENSMICG00000011066.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863526"/>
    <dbReference type="KEGG" id="mmur:105863526"/>
    <dbReference type="CTD" id="23673"/>
    <dbReference type="GeneTree" id="ENSGT01000000214440"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045335">
        <property type="term" value="C:phagocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098837">
        <property type="term" value="C:postsynaptic recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030672">
        <property type="term" value="C:synaptic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033344">
        <property type="term" value="P:cholesterol efflux"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="CDD" id="cd15876">
        <property type="entry name" value="SNARE_syntaxin12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00179">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000016">
        <property type="entry name" value="Syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000009">
        <property type="entry name" value="Syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF88">
        <property type="entry name" value="SYNTAXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="21">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00069800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033947.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="276" mass="31554" checksum="C40E5C1C382D286C" modified="2022-01-19" version="1">MSYGPLDMYRNPGPSGPQLRDFSSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQLQHSTNQLAKETNELLKELGSLPLPLSTSEQRQQKLQKERLMNDFSAALNNFQAVQRRVSEKEKESIARARAGSRLSAEERQREEQLVSFDSHEEWNQMQSQEDEVAITEQDLELIKERETAIRQLEADILDVNQIFKDLAVMIHDQGDLIDSIEANVESSEVHVERATDQLQRAAYYQKKSRKKMCILVLVLSVIIVILGLIIWLVYKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W578</accession>
    <name>A0A8C5W578_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W578"/>
    <dbReference type="Ensembl" id="ENSMICT00000040994.2">
        <property type="protein sequence ID" value="ENSMICP00000037153.2"/>
        <property type="gene ID" value="ENSMICG00000037711.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154388"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037153.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="197" mass="21888" checksum="310DE0606A99CC0A" modified="2022-01-19" version="1">IASADSHRVGDGNSAGGTFQPYLDSLWQELQQTDPMLLLSVVVAVFAVLLMLVFWKFIQSRRSSQRAVLLVGLCDSGKTLLFVRLDTQMSITDSCAIYRANNNWGNSLTLIDLPEWFKSSARALVFVVDNAVKDVAEFLFQVLIESMSLKNTPSFLIDCNKQDTAMAKSFQHCPCSAGKERVYLVCSHGFTGEHLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W5I2</accession>
    <name>A0A8C5W5I2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Solute carrier family 35 member B1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">SLC35B1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020092">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012645179.1">
        <property type="nucleotide sequence ID" value="XM_012789725.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W5I2"/>
    <dbReference type="Ensembl" id="ENSMICT00000032356.2">
        <property type="protein sequence ID" value="ENSMICP00000037651.1"/>
        <property type="gene ID" value="ENSMICG00000016462.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105885098"/>
    <dbReference type="CTD" id="10237"/>
    <dbReference type="GeneTree" id="ENSGT00940000157900"/>
    <dbReference type="OrthoDB" id="78344at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="315"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000037651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="39513" checksum="A96B5162EAB2EC56" modified="2022-01-19" version="1">MRPLPPVGDVRLELSPPPLPLPLPAVSGSPVSSSGRLMASSSSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGAKQETFTFALTLVFIQCVINAVFAKILIQFFDTARVDRTRSWLYAACSVSYLGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLRKKYPLAKYLCVLLIVAGVALFMYKPKKVVGMEERTVGYGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTLLLGAGILFTGELWEFLSFAERYPSITYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISSMQWVGTVLVFLGLGLDAKFGKGAKKTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W6P1</accession>
    <name>A0A8C5W6P1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Solute carrier family 22 member 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SLC22A6</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005851">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W6P1"/>
    <dbReference type="Ensembl" id="ENSMICT00000029882.2">
        <property type="protein sequence ID" value="ENSMICP00000036145.2"/>
        <property type="gene ID" value="ENSMICG00000026456.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000157004"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015139">
        <property type="term" value="F:alpha-ketoglutarate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015132">
        <property type="term" value="F:prostaglandin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097254">
        <property type="term" value="P:renal tubular secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17446">
        <property type="entry name" value="MFS_SLC22A6_OAT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000023">
        <property type="entry name" value="Solute carrier family 22 member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004749">
        <property type="entry name" value="Orgcat_transp/SVOP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00898">
        <property type="entry name" value="2A0119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="93"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000036145.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="554" mass="61213" checksum="23C624DB05422254" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W7K2</accession>
    <name>A0A8C5W7K2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA-associated factor 29</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Coiled-coil domain-containing protein 101</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">SAGA complex-associated factor 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">SGF29</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Interacts with dimethylated and trimethylated 'Lys-4' of histone H3 (H3K4me2 and H3K4me3), with a preference for the trimethylated form (H3K4me3). Component of some SAGA-type complexes. Component of the ADA2A-containing complex (ATAC), composed of KAT14, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. Interacts with (methylated) CGAS. Interacts with TADA3L, GCN5L2, SUPT3H and MYC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03021391">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619784.1">
        <property type="nucleotide sequence ID" value="XM_012764330.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012619786.1">
        <property type="nucleotide sequence ID" value="XM_012764332.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020137288.1">
        <property type="nucleotide sequence ID" value="XM_020281699.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5W7K2"/>
    <dbReference type="Ensembl" id="ENSMICT00000032981.2">
        <property type="protein sequence ID" value="ENSMICP00000026214.1"/>
        <property type="gene ID" value="ENSMICG00000009973.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000045338.2">
        <property type="protein sequence ID" value="ENSMICP00000036758.1"/>
        <property type="gene ID" value="ENSMICG00000009973.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105871132"/>
    <dbReference type="KEGG" id="mmur:105871132"/>
    <dbReference type="CTD" id="112869"/>
    <dbReference type="GeneTree" id="ENSGT00390000015229"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140672">
        <property type="term" value="C:ATAC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140003">
        <property type="term" value="F:histone H3K36me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140002">
        <property type="term" value="F:histone H3K4me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140034">
        <property type="term" value="F:methylation-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045738">
        <property type="term" value="P:negative regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045995">
        <property type="term" value="P:regulation of embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000026">
        <property type="entry name" value="SAGA-associated factor 29 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000029">
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            <dbReference type="PROSITE" id="PS51518"/>
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            <dbReference type="Ensembl" id="ENSMICP00000036758.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="293" mass="33224" checksum="52D147F2CAB89580" modified="2022-01-19" version="1">MALVSADSRIAELLTELHQLIKQTQEERSRSEHNLVNIQKTHERMQTENKISPYYRTKLRGLYTTAKADAEAECNILRKALDKIAEIKSLLEERRIAAKIAGLYNDSEPPRKTMRRGVLMTLLQQSAMTLPLWIGKPGDKPPPLCGAIPASGDYVAKPGDKVAARVKAVDGDEQWILAEVVSYSHATNKYEVDDIDEEGKERHTLSRRRIIPLPQWKANPETDPEALFQKEQLVLALYPQTTCFYRALIHAPPQRPQDDYSVLFEDTSYADGYSPPLNVAQRYVVACKEPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5W8W0</accession>
    <name>A0A8C5W8W0_MICMU</name>
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        <recommendedName>
            <fullName evidence="6">Splicing factor 3b subunit 2</fullName>
        </recommendedName>
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        <name evidence="4" type="primary">LOC105883799</name>
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    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:U12-type spliceosomal complex"/>
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        <property type="entry name" value="U2_snRNP_Complex_Component"/>
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    </dbReference>
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        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
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        </location>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="100738" checksum="72DAD2FAE441463D" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
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    <name>A0A8C5WA70_MICMU</name>
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        </alternativeName>
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            <taxon>Mammalia</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
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                <person name="Sullivan B."/>
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                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
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                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <text evidence="9">Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.</text>
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        <text evidence="9">Homotrimer.</text>
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            <location evidence="9">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
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        </subcellularLocation>
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            <topology evidence="9">Single-pass membrane protein</topology>
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        <subcellularLocation>
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        </subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.</text>
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        <text evidence="2 9">Belongs to the ERG2 family.</text>
    </comment>
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    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006716">
        <property type="entry name" value="ERG2_sigma1_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868">
        <property type="entry name" value="SIGMA 1-TYPE OPIOID RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10868:SF1">
        <property type="entry name" value="SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04622">
        <property type="entry name" value="ERG2_Sigma1R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034830065" description="Sigma non-opioid intracellular receptor 1" evidence="10">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000035520.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="193" mass="21938" checksum="EC757C40329092F7" modified="2022-01-19" version="1">MQWAVGWRWVWAALLLAAMAVLAQVVWLWLGPQSFEEIAQLARQYAGLDHELAFSRLIVLLRWLHPGHVLPDKELQWVFVNEGGWMGAMCLLHLFCTALGSRGHSGRYWDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLCSYARTYLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XEE6</accession>
    <name>A0A8C5XEE6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein SGT1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Suppressor of G2 allele of SKP1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">SUGT1</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Probably associates with SCF (SKP1-CUL1-F-box protein) complex through interaction with SKP1. Interacts with S100A6. Interacts with HSP90.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03017615">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03017616">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XEE6"/>
    <dbReference type="Ensembl" id="ENSMICT00000014620.3">
        <property type="protein sequence ID" value="ENSMICP00000013326.2"/>
        <property type="gene ID" value="ENSMICG00000014614.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000013700"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06489">
        <property type="entry name" value="p23_CS_hSgt1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000244">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000012">
        <property type="entry name" value="SGT1 homolog, MIS12 kinetochore complex assembly cochaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="19">
        <location>
            <begin position="137"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="18">
        <location>
            <begin position="244"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00069423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00075471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013326.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="333" mass="37924" checksum="97B21F83E8866EC2" modified="2022-01-19" version="1">MAAAAAGPATTQRFFQSCSDALIDKDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGNYCDAVADTKKSLELNPNNSTAMLRKGICEYHEKNYAAALETFTEGQKLYSTDADFSVWIKRCQEAQNGSESEVRTHQSKIKYDWYQTESQVIVTLMIKNVQKNDVNVEFSAKELSALVKLPSGEDYNLKLRLLYPIIPEQSTFKVLSTKIEIKMKKPEAVRWEMLEGQGDVSKPKQFIADVKNLYPSSSHYTRNWDKLVGEIKEEEKNEKLEGDAALNKLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XF19</accession>
    <name>A0A8C5XF19_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Phosphatidylinositol-binding clathrin assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="primary">PICALM</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).</text>
    </comment>
    <comment type="subunit">
        <text evidence="19">Binds to clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol 4,5- bisphosphate. Interacts with PIMREG; this interaction may change the subcellular location into the nucleus. Interacts with AP2A1 (via its alpha-appendage domain). Interacts (via N-terminus) with VAMP2; VAMP3; VAMP7 and VAMP8 (Via N-terminus). Interacts with LC3/MAP1LC3A.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Membrane</location>
            <location evidence="5">Clathrin-coated pit</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PICALM/SNAP91 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03006583">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XF19"/>
    <dbReference type="Ensembl" id="ENSMICT00000017270.3">
        <property type="protein sequence ID" value="ENSMICP00000015731.2"/>
        <property type="gene ID" value="ENSMICG00000017261.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183068"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:clathrin-coated pit"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:clathrin-coated vesicle"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:extrinsic component of presynaptic endocytic zone membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:1-phosphatidylinositol binding"/>
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        <property type="term" value="F:SNARE binding"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:synaptic vesicle budding from presynaptic endocytic zone membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ANTH_N_AP180"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
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        <property type="entry name" value="ANTH_dom_sf"/>
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        <property type="entry name" value="AP180-like"/>
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        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
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        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0168">Coated pit</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="23">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="561"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00055144"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00061829"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50942"/>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000015731.2"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="634" mass="69022" checksum="93A3B97BC57CD5A0" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XGJ3</accession>
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        <submittedName>
            <fullName evidence="2">Negative regulator of P-body association</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">NBDY</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome X"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0010607">
        <property type="term" value="P:negative regulation of cytoplasmic mRNA processing body assembly"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="entry name" value="NoBody"/>
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    <dbReference type="Pfam" id="PF21949">
        <property type="entry name" value="NoBody"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000020151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="68" mass="7059" checksum="FA3727879A1CE853" modified="2022-01-19" version="1">MGDQPCASGRSTLPPGNTREAKPPKKRCLLAPRWDYPEGTPNGGSTTLPSAPPPASASLKSHPAPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XII5</accession>
    <name>A0A8C5XII5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase cytochrome b560 subunit, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Integral membrane protein CII-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Malate dehydrogenase [quinone] cytochrome b560 subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">QPs-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">SDHC</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b560 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003084">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003085">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003086">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003087">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003088">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03003089">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XII5"/>
    <dbReference type="Ensembl" id="ENSMICT00000030563.2">
        <property type="protein sequence ID" value="ENSMICP00000026053.2"/>
        <property type="gene ID" value="ENSMICG00000007317.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000000566"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045273">
        <property type="term" value="C:respiratory chain complex II (succinate dehydrogenase)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000006">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.540:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.540">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00045847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00076718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00079783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000026053.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="147" mass="16389" checksum="7FF94B52ABE887EA" modified="2022-01-19" version="1">MAALLLRHVGRHCLRAHLSPQLCIRNAVPLGTTAKEEMERFWNKNTSSNRPLSPHISIYVYLFGLSALLLPGNFESYFEFVKSLSLGPALIHTAKFALVFPLMYHSWNGIRHLMWDLGKGLKIAQLYQSGVVVLVLTVLSSVGLAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XJD6</accession>
    <name>A0A8C5XJD6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acidic leucine-rich nuclear phosphoprotein 32 family member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ANP32E</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Multifunctional protein that is involved in the regulation of many processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 11">Belongs to the ANP32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03003007">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XJD6"/>
    <dbReference type="Ensembl" id="ENSMICT00000034343.2">
        <property type="protein sequence ID" value="ENSMICP00000028382.2"/>
        <property type="gene ID" value="ENSMICG00000015265.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000182907"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF5">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000028382.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="161" mass="18990" checksum="FB546B6AF1EC807C" modified="2022-01-19" version="1">MEMKKRINLELRNRAPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLELSDNIISGGLEVLAEKCPNLTYLNLSGNKIKDLSTVEALMEMTMMKMKRKMKLVHLKDMRRRRRKRRKKMRMKMKQAQNWERAKRKWASHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XPE0</accession>
    <name>A0A8C5XPE0_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Podocan like 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">PODNL1</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03027719">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XPE0"/>
    <dbReference type="Ensembl" id="ENSMICT00000047522.2">
        <property type="protein sequence ID" value="ENSMICP00000038758.2"/>
        <property type="gene ID" value="ENSMICG00000027429.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162059"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050333">
        <property type="entry name" value="SLRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712">
        <property type="entry name" value="AGAP008170-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45712:SF5">
        <property type="entry name" value="PODOCAN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034770205" evidence="3">
        <location>
            <begin position="26"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000038758.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="501" mass="55195" checksum="197BB2EFE69E9873" modified="2022-01-19" version="1">MVRGAGEGLRRLSLLLLLLWPGPLATPGMEDATFPHLGESSQPPPRACPPRCSCPRADTVDCNGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSSLRTLNLHNNRISSEGLPDEAFESLTQLQHIYVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGQKPALRSVYLHNNQLDNAGLPADAFRGSEAVATLSLSSNRLRYLPPSLPASLERLHLQNNLISKVPRGALSHQTQLRELYLQHNQLTDNGLDATTFSKLRSLEYLDLSHNQLATVPAGLPRTLAVLHLGRNRIRRVEAGRLRGARALRYLLLQHNALGSAGLPAGALRPLRGLHTLHLYGNGLDRVPLALPRRLHALVLPHNRVAALGARDLASTPGLAELNLAYNRLASARVHRRAFRRLRGLRSLDLAGNQLTRLPTGLPAGLRALRLQRNQLRGLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQALQVRGRLVSRAVPTPPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XSM2</accession>
    <name>A0A8C5XSM2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Hephaestin</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="31" type="primary">HEPH</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="31" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="31" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="23">Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:11149"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="24">Part of a complex composed of SLC40A1/ferroportin, TF/transferrin and HEPH/hephaestin that transfers iron from cells to transferrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Basolateral cell membrane</location>
            <topology evidence="21">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="ABDC03002544">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03002545">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XSM2"/>
    <dbReference type="Ensembl" id="ENSMICT00000067324.1">
        <property type="protein sequence ID" value="ENSMICP00000040797.1"/>
        <property type="gene ID" value="ENSMICG00000010448.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000158517"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016323">
        <property type="term" value="C:basolateral plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04222">
        <property type="entry name" value="CuRO_1_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11021">
        <property type="entry name" value="CuRO_2_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04224">
        <property type="entry name" value="CuRO_3_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04225">
        <property type="entry name" value="CuRO_5_ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000009">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000015">
        <property type="entry name" value="Ceruloplasmin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000075">
        <property type="entry name" value="hephaestin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000002">
        <property type="entry name" value="Hephaestin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048236">
        <property type="entry name" value="Ceruloplasmin-like_CuRO_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF221">
        <property type="entry name" value="HEPHAESTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="18 26" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 27" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 26" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 26" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034515558" description="Hephaestin" evidence="27">
        <location>
            <begin position="27"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="26">
        <location>
            <begin position="1109"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="30">
        <location>
            <begin position="101"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="28">
        <location>
            <begin position="235"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="30">
        <location>
            <begin position="458"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="30">
        <location>
            <begin position="812"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="29">
        <location>
            <begin position="966"/>
            <end position="1067"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00054029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00065139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00068243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1160" mass="130725" checksum="BF6A1046A6942420" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XUD2</accession>
    <name>A0A8C5XUD2_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SYF2</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SYF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03001839">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03001840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XUD2"/>
    <dbReference type="Ensembl" id="ENSMICT00000065635.1">
        <property type="protein sequence ID" value="ENSMICP00000041589.1"/>
        <property type="gene ID" value="ENSMICG00000016191.3"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00390000017845"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048568">
        <property type="term" value="P:embryonic organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007369">
        <property type="term" value="P:gastrulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001701">
        <property type="term" value="P:in utero embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="207" mass="24647" checksum="364CCA10966700D0" modified="2022-01-19" version="1">KREQRLRKFRELHLKRVTRKLNHPEVPQKARLVMGTEGIGKRKLLGTTLLECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMEAYERQREKHGEEFFPTSDSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5XW61</accession>
    <name>A0A8C5XW61_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Insulin gene enhancer protein ISL-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">ISL2</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with LHX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03004947">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012594814.1">
        <property type="nucleotide sequence ID" value="XM_012739360.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5XW61"/>
    <dbReference type="Ensembl" id="ENSMICT00000066193.1">
        <property type="protein sequence ID" value="ENSMICP00000041869.1"/>
        <property type="gene ID" value="ENSMICG00000044370.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105857184"/>
    <dbReference type="KEGG" id="mmur:105857184"/>
    <dbReference type="CTD" id="64843"/>
    <dbReference type="GeneTree" id="ENSGT00940000153731"/>
    <dbReference type="OrthoDB" id="125004at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045665">
        <property type="term" value="P:negative regulation of neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031290">
        <property type="term" value="P:retinal ganglion cell axon guidance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021520">
        <property type="term" value="P:spinal cord motor neuron cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021524">
        <property type="term" value="P:visceral motor neuron differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09366">
        <property type="entry name" value="LIM1_Isl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09471">
        <property type="entry name" value="LIM2_Isl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000034">
        <property type="entry name" value="Insulin gene enhancer protein ISL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000041">
        <property type="entry name" value="insulin gene enhancer protein ISL-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000068">
        <property type="entry name" value="Insulin gene enhancer protein ISL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047169">
        <property type="entry name" value="ISL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047244">
        <property type="entry name" value="ISL1/2-like_LIM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24204:SF2">
        <property type="entry name" value="INSULIN GENE ENHANCER PROTEIN ISL-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="7 13 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 13 15" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 14" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="25"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="17">
        <location>
            <begin position="88"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="18">
        <location>
            <begin position="189"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="13">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="151"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="326"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="344"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="359" mass="39697" checksum="0A04BFE9BAFD9E66" modified="2022-01-19" version="1">MVDIIFHCPFLGAMGDHPKKKPGTAMCVGCGSQIHDQFILRVSPDLEWHAACLKCAECSQYLDETCTCFVRDGKTYCKRDYVRLFGIKCAKCQVGFSSSDLVMRARDSVYHIECFRCSVCSRQLLPGDEFSLREHELLCRADHGLLLERAAAGSPRSPGPLPGARGLHLPEPGAARQPSLRQHAHKQAEKTTRVRTVLNEKQLHTLRTCYAANPRPDALMKEQLVEMTGLSPRVIRVWFQNKRCKDKKKSILMKQLQQQQHNDKTSLQGLTGTPLVAGSPVCHESAMQGSAVEVQTYQPPWKALSEFALQSDLDQPAFQQLVSFSESGSLGTSSGSDVTSLSSQLPDTPNSMVPSPVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y104</accession>
    <name>A0A8C5Y104_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Zinc finger protein 33B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">LOC105868241</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03021044">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614296.1">
        <property type="nucleotide sequence ID" value="XM_012758842.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614297.1">
        <property type="nucleotide sequence ID" value="XM_012758843.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012614298.1">
        <property type="nucleotide sequence ID" value="XM_012758844.2"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000070598.1">
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        <location>
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        <location>
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    <feature type="domain" description="C2H2-type" evidence="15">
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        <source>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="992" mass="114707" checksum="A1D3186926F2BFC6" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y1Z2</accession>
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        <recommendedName>
            <fullName evidence="14">Relaxin receptor 2</fullName>
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        <alternativeName>
            <fullName evidence="17">G-protein coupled receptor 106</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">G-protein coupled receptor affecting testicular descent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Leucine-rich repeat-containing G-protein coupled receptor 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Relaxin family peptide receptor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">RXFP2</name>
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    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="ENSMICG00000011921.3"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008528">
        <property type="term" value="F:G protein-coupled peptide receptor activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016500">
        <property type="term" value="F:protein-hormone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y7D6</accession>
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            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
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                <person name="Yoder A."/>
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                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>IDENTIFICATION</scope>
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    <sequence length="110" mass="12444" checksum="D66BDDE2A1102C0E" modified="2022-01-19" version="1">MQAALEVTARYCGRELEQYGQCVAAKPESWQRDCHHLKMSIARCTSSHPIIRQIRQACAEPFESFEECLRQNEAAVGNCAEHVRRFLQCAEQVQPPRSPTTMEAQPLPAS</sequence>
</entry>
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    <accession>A0A8C5Y7W3</accession>
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            <fullName evidence="12">Phosphodiesterase</fullName>
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        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
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                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
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                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>3',5'-cyclic AMP + H2O = AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25277"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.4.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:25278"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="12"/>
    <dbReference type="EMBL" id="ABDC03027840">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012646103.1">
        <property type="nucleotide sequence ID" value="XM_012790649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y7W3"/>
    <dbReference type="Ensembl" id="ENSMICT00000060738.1">
        <property type="protein sequence ID" value="ENSMICP00000046738.1"/>
        <property type="gene ID" value="ENSMICG00000026345.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105885589"/>
    <dbReference type="CTD" id="5141"/>
    <dbReference type="GeneTree" id="ENSGT00940000159788"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="UniPathway" id="UPA00762">
        <property type="reaction ID" value="UER00747"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 24"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
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    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004115">
        <property type="term" value="F:3',5'-cyclic-AMP phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006198">
        <property type="term" value="P:cAMP catabolic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="GO" id="GO:0071466">
        <property type="term" value="P:cellular response to xenobiotic stimulus"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106070">
        <property type="term" value="P:regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141161">
        <property type="term" value="P:regulation of cAMP/PKA signal transduction"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007608">
        <property type="term" value="P:sensory perception of smell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000001">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040844">
        <property type="entry name" value="PDE4_UCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18100">
        <property type="entry name" value="PDE4_UCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="14">
        <location>
            <begin position="356"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="294"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="681"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="711"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="432"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="641"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004703"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009517"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033681"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000046738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="882" mass="97354" checksum="FA5EC4513EFECF10" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8N9</accession>
    <name>A0A8C5Y8N9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Olfactory receptor</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the G-protein coupled receptor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005815">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000070079.1">
        <property type="protein sequence ID" value="ENSMICP00000047420.1"/>
        <property type="gene ID" value="ENSMICG00000042992.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT01150000286921"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 5"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004984">
        <property type="term" value="F:olfactory receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15407">
        <property type="entry name" value="7tmA_OR5B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000003">
        <property type="entry name" value="Olfactory receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000276">
        <property type="entry name" value="GPCR_Rhodpsn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000725">
        <property type="entry name" value="Olfact_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48018">
        <property type="entry name" value="OLFACTORY RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13853">
        <property type="entry name" value="7tm_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00237">
        <property type="entry name" value="GPCRRHODOPSN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00245">
        <property type="entry name" value="OLFACTORYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00237">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0552">Olfaction</keyword>
    <keyword evidence="6 8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 8" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="10">
        <location>
            <begin position="42"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="315" mass="35144" checksum="9DAF639B5E5193B7" modified="2022-01-19" version="1">MTSMENSSEVNEFRLLGLTDIPELQVPLFITFTLVYLITVIGNLGMIVLILLDSRLHTPMYFFLSNLSLADCVYSSAVTPKVMVGLLTGEKVISYGGCVAQMFFFVAFASVDCFLLAVMAYDRHAAVCKPLRYTATMTTSACTHMVMGCYVWGVVESAIHTGLTFRLSFCHSNVVHHFFCDIPPILALSCSDLYMNEIVLFILAAFNVVFALTVILTSYLFILIAILRMHSAEGQKKAFSTCASHLTAVTIFYGTVIFMYLQPSSSHSMDNDQMASVFYTIIIPMLNPIVYSLRNKEVNNAFKKAMEKMKTLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5Y8X4</accession>
    <name>A0A8C5Y8X4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03003596">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5Y8X4"/>
    <dbReference type="Ensembl" id="ENSMICT00000065305.1">
        <property type="protein sequence ID" value="ENSMICP00000047737.1"/>
        <property type="gene ID" value="ENSMICG00000042237.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00950000183013"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019814">
        <property type="term" value="C:immunoglobulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04981">
        <property type="entry name" value="IgV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000556">
        <property type="entry name" value="Immunoglobulin heavy variable 7-81 (non-functional)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036179">
        <property type="entry name" value="Ig-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013106">
        <property type="entry name" value="Ig_V-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050199">
        <property type="entry name" value="IgHV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23266">
        <property type="entry name" value="IMMUNOGLOBULIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07686">
        <property type="entry name" value="V-set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00406">
        <property type="entry name" value="IGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48726">
        <property type="entry name" value="Immunoglobulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0391">Immunity</keyword>
    <keyword evidence="9" id="KW-1280">Immunoglobulin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Ig-like" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000047737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="101" mass="11099" checksum="85611A7D59B010AF" modified="2022-01-19" version="1">QVQLVQSGAEVKPPGASVKVSCKASGYTFTSYYMHWVRQAPGQGLEWMGRINPSSGGTSYAQKFQGRVTMTRDTSTSTAYMELSSLRPEDTAVYYCARDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YBU9</accession>
    <name>A0A8C5YBU9_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline rich transmembrane protein 1B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRRT1B</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CD225/Dispanin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014954">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YBU9"/>
    <dbReference type="Ensembl" id="ENSMICT00000065841.1">
        <property type="protein sequence ID" value="ENSMICP00000048763.1"/>
        <property type="gene ID" value="ENSMICG00000044047.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000163383"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051423">
        <property type="entry name" value="CD225/Dispanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007593">
        <property type="entry name" value="CD225/Dispanin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948">
        <property type="entry name" value="NG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14948:SF18">
        <property type="entry name" value="PROLINE RICH TRANSMEMBRANE PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04505">
        <property type="entry name" value="CD225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="230" mass="23482" checksum="59CBE6EFBD6724C3" modified="2022-01-19" version="1">GDAKAGGSPVPAEDARSPTPPALPALPRRPQPLDEDAGPSEDAAGAGAGGSEPAPEEPAAAGEARPEPKAAAGGVLPIGFVGEPPPYAPPDPKAVHLLYPPFPQVPVLFQAAPAPAAAFPPPAPLYPAAPAFPFPVYGSPVAAPPPAEHRPLPKDYMVESVLATLFCCLLTGLVAIVYSHETRAALGRGDLAQAEAASRKARSLVLFSLLFGVFVSTSWVIYVVVALYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YBW1</accession>
    <name>A0A8C5YBW1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mesoderm posterior bHLH transcription factor 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MESP2</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03013844">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YBW1"/>
    <dbReference type="Ensembl" id="ENSMICT00000070252.1">
        <property type="protein sequence ID" value="ENSMICP00000049112.1"/>
        <property type="gene ID" value="ENSMICG00000044704.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00530000063712"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003007">
        <property type="term" value="P:heart morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001707">
        <property type="term" value="P:mesoderm formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032525">
        <property type="term" value="P:somite rostral/caudal axis specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040259">
        <property type="entry name" value="Mesogenin/MesP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937">
        <property type="entry name" value="IP14615P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20937:SF17">
        <property type="entry name" value="MESODERM POSTERIOR PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="59"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="348" mass="36627" checksum="6EC6D4C35882965A" modified="2022-01-19" version="1">MAQSPPQSLLSHDHWIFSQGWGWAGHSDSTSPASSSDSSGSCPYDSTRGPSRPAPPACGARRARTGRRRQRQSASEREKLRMRTLAPPCTSCAVPAASLTKIETLRLAIRYIGHLSARGSLQRRRRRRSDAASAGAAAVPDGGAQAQVQVQAQVQVRGPGLGSAARAGASWGSPPACPGPGAVPEHLGSGGPDTDPWVTPPYCPKIQSPTHPSQGRTPDESFWMPPQAFPRTQTSPEPGNQAVPWTTPPGPVELAAVYQGVSVSPESCLSLGSPPLLPRPSCQRLQPQTQWGCWSHSAEVLPGSEGQAPGPAFQLHEASPPQSSGLPLGGCPELWPEDLEGAHLGLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YEY9</accession>
    <name>A0A8C5YEY9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein light chain Tctex-type 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain Tctex-type family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020829">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YEY9"/>
    <dbReference type="Ensembl" id="ENSMICT00000065957.1">
        <property type="protein sequence ID" value="ENSMICP00000050001.1"/>
        <property type="gene ID" value="ENSMICG00000042727.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000154531"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 17"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF19">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11806" checksum="F245FEFFFA729850" modified="2022-01-19" version="1">GCWQHLSGKMEDYQATEETTFVVDEVSNNVKEAIESAIGPGVVAHAFNQWTTNVVEQTLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTIAFGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C5YFT5</accession>
    <name>A0A8C5YFT5_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">V-type proton ATPase catalytic subunit A</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">V-ATPase 69 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Vacuolar proton pump subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">ATP6V1A</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR. Interacts with the V0 complex V-ATPase subunit a4 ATP6V0A4. Interacts with WFS1. Interacts with alpha-crystallin B chain/CRYAB and with MTOR, forming a ternary complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasmic vesicle</location>
            <location evidence="11">Clathrin-coated vesicle membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="ABDC03001145">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C5YFT5"/>
    <dbReference type="Ensembl" id="ENSMICT00000073027.1">
        <property type="protein sequence ID" value="ENSMICP00000050774.1"/>
        <property type="gene ID" value="ENSMICG00000049182.1"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00550000074787"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042592">
        <property type="term" value="P:homeostatic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF9">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="18">
        <location>
            <begin position="22"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="19">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="17">
        <location>
            <begin position="230"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="20">
        <location>
            <begin position="463"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="617" mass="68331" checksum="06B127D8B50AA03E" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EH26</accession>
    <name>A0A8C6EH26_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Essential for reactive oxygen species protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">CYBC1</name>
        <name evidence="13" type="synonym">C16H17orf62</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYBC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03019670">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012777272.1"/>
    </dbReference>
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    <dbReference type="Ensembl" id="ENSMICT00000065610.1">
        <property type="protein sequence ID" value="ENSMICP00000041928.1"/>
        <property type="gene ID" value="ENSMICG00000038561.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105878082"/>
    <dbReference type="KEGG" id="mmur:105878082"/>
    <dbReference type="GeneTree" id="ENSGT00390000004691"/>
    <dbReference type="OrthoDB" id="10022724at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
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        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:innate immune response"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:respiratory burst after phagocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027846">
        <property type="entry name" value="Cybc1"/>
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        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31837:SF3">
        <property type="entry name" value="CYTOCHROME B-245 CHAPERONE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15169">
        <property type="entry name" value="Cybc1_Eros"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
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    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00030424"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Ensembl" id="ENSMICP00000041928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="187" mass="20884" checksum="6B389DCAD94C4A29" modified="2022-01-19" version="1">MYMQVEMRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVAGCLFVAVQNLEDWEEAVFNKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLSDIRDVNVEEEKVRYFGRGYSVVLRFATGFSHPLTQSAVMGRRSDVEAVAKLITNFLELHRLESPAELSQSSDSEASDPGNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EIF5</accession>
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        <submittedName>
            <fullName evidence="9">DC-STAMP domain containing 2</fullName>
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        <name evidence="9" type="primary">DCST2</name>
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    <organism evidence="9 10">
        <name type="scientific">Microcebus murinus</name>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
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            <taxon>Microcebus</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Ensembl" id="ENSMICT00000068883.1">
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        <property type="gene ID" value="ENSMICG00000044446.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105873181"/>
    <dbReference type="CTD" id="127579"/>
    <dbReference type="GeneTree" id="ENSGT00940000153269"/>
    <dbReference type="OrthoDB" id="6598372at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="Ensembl"/>
    </dbReference>
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        <property type="term" value="P:sperm-egg recognition"/>
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        <property type="project" value="Ensembl"/>
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    <dbReference type="InterPro" id="IPR051856">
        <property type="entry name" value="CSR-E3_Ligase_Protein"/>
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        <property type="entry name" value="DC_STAMP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058842">
        <property type="entry name" value="DCST1_C"/>
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    <dbReference type="PANTHER" id="PTHR21041:SF6">
        <property type="entry name" value="DC-STAMP DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21041">
        <property type="entry name" value="DENDRITIC CELL-SPECIFIC TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07782">
        <property type="entry name" value="DC_STAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dcst2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-RING_DCST1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Dendritic cell-specific transmembrane protein-like" evidence="7">
        <location>
            <begin position="354"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="E3 ubiquitin-protein ligase DCST1-like C-terminal" evidence="8">
        <location>
            <begin position="598"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="689"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
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        </location>
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        <location>
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        </location>
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            <end position="765"/>
        </location>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07782"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF26037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000044221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="773" mass="86486" checksum="0192DC5FB9258CC3" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8C6EKW0</accession>
    <name>A0A8C6EKW0_MICMU</name>
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        <submittedName>
            <fullName evidence="6">Small integral membrane protein 18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SMIM18</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
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            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03023834">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639592.1">
        <property type="nucleotide sequence ID" value="XM_012784138.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639593.1">
        <property type="nucleotide sequence ID" value="XM_012784139.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012639594.1">
        <property type="nucleotide sequence ID" value="XM_012784140.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_020138431.1">
        <property type="nucleotide sequence ID" value="XM_020282842.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8C6EKW0"/>
    <dbReference type="SMR" id="A0A8C6EKW0"/>
    <dbReference type="Ensembl" id="ENSMICT00000060702.1">
        <property type="protein sequence ID" value="ENSMICP00000049276.1"/>
        <property type="gene ID" value="ENSMICG00000042305.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105882053"/>
    <dbReference type="CTD" id="100507341"/>
    <dbReference type="GeneTree" id="ENSGT00410000029064"/>
    <dbReference type="OrthoDB" id="9944050at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20255">
        <property type="entry name" value="CASIMO1_SMIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053081">
        <property type="entry name" value="SIM_Modulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031671">
        <property type="entry name" value="SMIM5/18/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36982">
        <property type="entry name" value="CLCA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36982:SF1">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15831">
        <property type="entry name" value="SMIM5_18_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="95" mass="11088" checksum="02D6026BDEF80CA7" modified="2022-01-19" version="1">MASSHWNETTTSVYQYLGFQVQKIYPFHDNWNTACFVILLLFIFTVVSLVVLAFLYEVLDCCCCVKNKTVKDLKSEPNPLRSMMDNIRKRETEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EMN3</accession>
    <name>A0A8B7EMN3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-1-phosphate guanylyltransferase regulatory subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GDP-mannose pyrophosphorylase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">GTP-mannose-1-phosphate guanylyltransferase alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">GMPPA</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="13">Liver</tissue>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Regulatory subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex; reduces the catalytic activity of GMPPB when part of the complex. Mediates allosteric feedback inhibition of GMPPB catalytic activity upon binding GDP-alpha-D-mannose. Together with GMPPB regulates GDP-alpha-D-mannose levels.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex composed of 4 GMPPA subunits and 8 GMPPB subunits; the complex is organized into three layers, a central layer made up of 2 GMPPA dimers sandwiched between two layers each made up of 2 GMPPB dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03010755">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595589.1">
        <property type="nucleotide sequence ID" value="XM_012740135.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595590.1">
        <property type="nucleotide sequence ID" value="XM_012740136.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595591.1">
        <property type="nucleotide sequence ID" value="XM_012740137.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012595592.1">
        <property type="nucleotide sequence ID" value="XM_012740138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EMN3"/>
    <dbReference type="Ensembl" id="ENSMICT00000045086.2">
        <property type="protein sequence ID" value="ENSMICP00000025222.1"/>
        <property type="gene ID" value="ENSMICG00000001329.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105857659"/>
    <dbReference type="KEGG" id="mmur:105857659"/>
    <dbReference type="CTD" id="29926"/>
    <dbReference type="GeneTree" id="ENSGT00940000157018"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06428">
        <property type="entry name" value="M1P_guanylylT_A_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000071">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000023">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase alpha (Predicted)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="288"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000025222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="RefSeq" id="XP_012595589.1"/>
        </source>
    </evidence>
    <sequence length="425" mass="46820" checksum="32280F430C29C230" modified="2022-01-19" version="1">MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEPLTQFLETAQQEFNLPIRYLQEFAPLGTGGGLYHFRDQILAGGPEAFFVLNADVCSDFPLNAMLDAHRCQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDVFQRNQQDRQLCLALGEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVYLTDGIWSQIKSAGSALYASRLYLGRYEFTHPERLAKHTPGGPQIRGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRESIVLHGATIQEHTCVLHSIVGWGSTVGRWARVEGTPNDPNPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7EU43</accession>
    <name>A0A8B7EU43_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 13">Nuclear transport factor 2</fullName>
            <shortName evidence="13">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">NUTF2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. Interacts with RAN (GDP-bound form); the interaction is direct and regulates RAN nuclear import. Interacts with the nucleoporins NUP54, NUP58 and NUP62 (via FG repeats); recruits NUTF2 to the nuclear pore complex a step required for NUTF2-mediated GDP-bound RAN nuclear import. Interacts with CAPG; mediates its nuclear import.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03024318">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597918.1">
        <property type="nucleotide sequence ID" value="XM_012742464.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597920.1">
        <property type="nucleotide sequence ID" value="XM_012742466.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012597921.1">
        <property type="nucleotide sequence ID" value="XM_012742467.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7EU43"/>
    <dbReference type="SMR" id="A0A8B7EU43"/>
    <dbReference type="Ensembl" id="ENSMICT00000041109.2">
        <property type="protein sequence ID" value="ENSMICP00000033807.1"/>
        <property type="gene ID" value="ENSMICG00000028936.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105858979"/>
    <dbReference type="KEGG" id="mmur:105858979"/>
    <dbReference type="CTD" id="10204"/>
    <dbReference type="GeneTree" id="ENSGT00510000047030"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 20"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000007">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="14">
        <location>
            <begin position="10"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000033807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="127" mass="14478" checksum="817752F20E262FD3" modified="2022-01-19" version="1">MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F4V3</accession>
    <name>A0A8B7F4V3_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">26S proteasome AAA-ATPase subunit RPT6</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Proteasome 26S subunit ATPase 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Proteasome subunit p45</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">p45/SUG</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">PSMC5</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components. Component of a complex with USP49 and RUVBL1. Interacts with PRPF19. Interacts with TRIM5. Interacts with NDC80. Interacts with PAAF1. Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR). Interacts with ERCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020238">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012602728.1">
        <property type="nucleotide sequence ID" value="XM_012747274.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F4V3"/>
    <dbReference type="Ensembl" id="ENSMICT00000009989.3">
        <property type="protein sequence ID" value="ENSMICP00000009098.2"/>
        <property type="gene ID" value="ENSMICG00000009989.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861623"/>
    <dbReference type="KEGG" id="mmur:105861623"/>
    <dbReference type="CTD" id="5705"/>
    <dbReference type="GeneTree" id="ENSGT01020000230346"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140297">
        <property type="term" value="F:DNA-binding transcription factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140296">
        <property type="term" value="F:general transcription initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031531">
        <property type="term" value="F:thyrotropin-releasing hormone receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="191"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000009098.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="415" mass="46425" checksum="550E2480866F4191" modified="2022-01-19" version="1">MPAVSAGGKMALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F5G6</accession>
    <name>A0A8B7F5G6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small integral membrane protein 10-like protein 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">LOC105867679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1" key="3">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03034994">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03035002">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012613427.1">
        <property type="nucleotide sequence ID" value="XM_012757973.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F5G6"/>
    <dbReference type="Ensembl" id="ENSMICT00000064750.1">
        <property type="protein sequence ID" value="ENSMICP00000044830.1"/>
        <property type="gene ID" value="ENSMICG00000048125.1"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000069992.1">
        <property type="protein sequence ID" value="ENSMICP00000049367.1"/>
        <property type="gene ID" value="ENSMICG00000043469.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105867679"/>
    <dbReference type="KEGG" id="mmur:105861746"/>
    <dbReference type="KEGG" id="mmur:105867679"/>
    <dbReference type="GeneTree" id="ENSGT00390000014547"/>
    <dbReference type="OrthoDB" id="9619930at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029367">
        <property type="entry name" value="SMIM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34446">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34446:SF3">
        <property type="entry name" value="SMALL INTEGRAL MEMBRANE PROTEIN 10-LIKE PROTEIN 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15118">
        <property type="entry name" value="DUF4560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000049367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8419" checksum="33CD7A03A2FBB8D1" modified="2022-01-19" version="1">MAASAALSAAAAAAALSGLAVRLSRSAAARSSYGAFCKGLTRTLLTFFDLAWRLRMNFPYFYIVASVMLNVRLQVRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F5S5</accession>
    <name>A0A8B7F5S5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Zinc finger protein 84</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ZNF84</name>
        <name evidence="17" type="synonym">LOC105861820</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in transcriptional regulation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03024944">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F5S5"/>
    <dbReference type="Ensembl" id="ENSMICT00000044297.2">
        <property type="protein sequence ID" value="ENSMICP00000018285.2"/>
        <property type="gene ID" value="ENSMICG00000031977.2"/>
    </dbReference>
    <dbReference type="GeneTree" id="ENSGT00940000162931"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 21"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07765">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger and SCAN domain-containing 20"/>
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        <property type="entry name" value="Zinc finger protein 133"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 184"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="zinc finger protein 197 isoform X1"/>
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        <property type="entry name" value="zinc finger protein 268 isoform X1"/>
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        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="Zinc finger protein 347"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 358"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zinc finger protein 37 homolog"/>
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        <property type="entry name" value="Zinc finger protein 550"/>
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        <property type="entry name" value="Zinc finger protein 768"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Zinc finger protein 793"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="19"/>
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        <property type="entry name" value="KRAB"/>
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        <property type="entry name" value="KRAB_dom_sf"/>
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        <property type="entry name" value="Znf_C2H2-type"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-C2H2"/>
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        <property type="entry name" value="KRAB"/>
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    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109640">
        <property type="entry name" value="KRAB domain (Kruppel-associated box)"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="KRAB" evidence="16">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="209"/>
            <end position="236"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="237"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="265"/>
            <end position="292"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="293"/>
            <end position="320"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="321"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="405"/>
            <end position="432"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="433"/>
            <end position="460"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="461"/>
            <end position="488"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="517"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="545"/>
            <end position="572"/>
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    </feature>
    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="573"/>
            <end position="600"/>
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    <feature type="domain" description="C2H2-type" evidence="15">
        <location>
            <begin position="601"/>
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            <begin position="713"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00003767"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50805"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000018285.2"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="740" mass="85922" checksum="953D597D59600622" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F6A7</accession>
    <name>A0A8B7F6A7_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosducin-like protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">PDCL3</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts (via thioredoxin fold region) with KDR/VEGFR2 (via juxtamembrane domain). Forms ternary complexes with the chaperonin CCT complex and actin substrate, leading to inhibition of actin folding. Interacts with XIAP (via BIR 3 and RING domain). Interacts with HSP90AA1 and HSP90AB1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03005377">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012603323.1">
        <property type="nucleotide sequence ID" value="XM_012747869.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F6A7"/>
    <dbReference type="Ensembl" id="ENSMICT00000000657.3">
        <property type="protein sequence ID" value="ENSMICP00000000590.3"/>
        <property type="gene ID" value="ENSMICG00000000657.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105861942"/>
    <dbReference type="KEGG" id="mmur:105861942"/>
    <dbReference type="CTD" id="79031"/>
    <dbReference type="GeneTree" id="ENSGT00940000154295"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043184">
        <property type="term" value="F:vascular endothelial growth factor receptor 2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001525">
        <property type="term" value="P:angiogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="phosducin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01552">
        <property type="entry name" value="phd_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF4">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0037">Angiogenesis</keyword>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="15">
        <location>
            <begin position="31"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000000590.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="240" mass="27619" checksum="F384A0FC39783839" modified="2022-01-19" version="1">MQDPNADTEWNDILRKKGILPSKESLEDLEKEAEEEEQRVLQQSVVKTYEDMTLEELEDHEDEFNEEDERAIEMYRQQRLAEWKATKLKNKFGEVLEISGKDYVQEVTKAGEGLWVVLHLYKQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTRDELEWKLSESGAVKTDLEENPKKPIEDTLLSSVRCSVPLRRDSDSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F904</accession>
    <name>A0A8B7F904_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Lysine-specific demethylase</fullName>
            <ecNumber evidence="14">1.14.11.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">KDM3B</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(9)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:60188"/>
            <dbReference type="Rhea" id="RHEA-COMP:15541"/>
            <dbReference type="Rhea" id="RHEA-COMP:15546"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="14">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.</text>
    </comment>
    <comment type="domain">
        <text evidence="14">The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the JHDM2 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.65" evidence="14"/>
    <dbReference type="EMBL" id="ABDC03022466">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ABDC03022467">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604431.1">
        <property type="nucleotide sequence ID" value="XM_012748977.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000046204.2">
        <property type="protein sequence ID" value="ENSMICP00000027330.1"/>
        <property type="gene ID" value="ENSMICG00000001706.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105862588"/>
    <dbReference type="CTD" id="51780"/>
    <dbReference type="GeneTree" id="ENSGT00940000158095"/>
    <dbReference type="OrthoDB" id="1667110at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140683">
        <property type="term" value="F:histone H3K9me/H3K9me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000004">
        <property type="entry name" value="Putative lysine-specific demethylase 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054294">
        <property type="entry name" value="DUF7030"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054503">
        <property type="entry name" value="KDM3AB_Tudor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054504">
        <property type="entry name" value="PWWP_KDM3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF8">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22989">
        <property type="entry name" value="DUF7030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22988">
        <property type="entry name" value="PWWP_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22987">
        <property type="entry name" value="Tudor_KDM3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 14" id="KW-0408">Iron</keyword>
    <keyword evidence="2 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133539" description="Lysine-specific demethylase" evidence="16">
        <location>
            <begin position="27"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="17">
        <location>
            <begin position="1498"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="254"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="652"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="718"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="805"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1284"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="724"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1143"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1175"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000027330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="1761" mass="191677" checksum="3D1527F5A4755DA2" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7F979</accession>
    <name>A0A8B7F979_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoside diphosphate kinase homolog 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">3'-5' exonuclease NME5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">NME5</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the axonemal radial spoke complex 1 (RS1), at least composed of spoke head proteins RSPH1, RSPH3, RSPH9 and the cilia-specific component RSPH4A or sperm-specific component RSPH6A, spoke stalk proteins RSPH14, DNAJB13, DYDC1, ROPN1L and NME5, and the anchor protein IQUB. Interacts with IQUB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Flagellum axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15 16">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022461">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012604555.1">
        <property type="nucleotide sequence ID" value="XM_012749101.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7F979"/>
    <dbReference type="Ensembl" id="ENSMICT00000046284.2">
        <property type="protein sequence ID" value="ENSMICP00000031926.1"/>
        <property type="gene ID" value="ENSMICG00000027492.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105862647"/>
    <dbReference type="KEGG" id="mmur:105862647"/>
    <dbReference type="CTD" id="8382"/>
    <dbReference type="GeneTree" id="ENSGT00940000159595"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 19"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001534">
        <property type="term" value="C:radial spoke"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036126">
        <property type="term" value="C:sperm flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003351">
        <property type="term" value="P:epithelial cilium movement involved in extracellular fluid movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051649">
        <property type="term" value="P:establishment of localization in cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902176">
        <property type="term" value="P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007286">
        <property type="term" value="P:spermatid development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021591">
        <property type="term" value="P:ventricular system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd22970">
        <property type="entry name" value="DD_NDKH5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04418">
        <property type="entry name" value="NDPk5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.890.10:FF:000008">
        <property type="entry name" value="Nucleoside diphosphate kinase homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000008">
        <property type="entry name" value="nucleoside diphosphate kinase homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.890.10">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007858">
        <property type="entry name" value="Dpy-30_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012410">
        <property type="entry name" value="NDK_H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF1">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05186">
        <property type="entry name" value="Dpy-30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036504">
        <property type="entry name" value="NDK_H5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0221">Differentiation</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0744">Spermatogenesis</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="17">
        <location>
            <begin position="12"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00080200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000031926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="212" mass="24183" checksum="0F76BF6B39B5D28C" modified="2022-01-19" version="1">MEVSMPLPQIYVEKTLAIIKPDIVDKEEEIQDIIVRSGFTIVQRRKLHLSPEQCSNFYVEQYGKMFFPNLTAYMSSGPLVAMILARHKAISHWKELLGPSNSLVAKETHPDSLRAIYGTDDLRNALHGSNDFTAAEREIRFMFPEVIVEPIPIGQSAKDYLNLYVTPTLLQGLTELCKQKPGDPFVWLADWLLKNNPNKPKLCHYQITEEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FB06</accession>
    <name>A0A8B7FB06_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zinc finger and BTB domain containing 21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ZBTB21</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03033239">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605300.1">
        <property type="nucleotide sequence ID" value="XM_012749846.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FB06"/>
    <dbReference type="Ensembl" id="ENSMICT00000064027.1">
        <property type="protein sequence ID" value="ENSMICP00000043074.1"/>
        <property type="gene ID" value="ENSMICG00000042192.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105863086"/>
    <dbReference type="CTD" id="49854"/>
    <dbReference type="GeneTree" id="ENSGT00940000161028"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 31"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001227">
        <property type="term" value="F:DNA-binding transcription repressor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008327">
        <property type="term" value="F:methyl-CpG binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031208">
        <property type="term" value="F:POZ domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18209">
        <property type="entry name" value="BTB_POZ_ZBTB21_ZNF295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000777">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001637">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 21"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.710.10:FF:000065">
        <property type="entry name" value="zinc finger and BTB domain-containing protein 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
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    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
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    <dbReference type="InterPro" id="IPR041011">
        <property type="entry name" value="Znf_C2H2_6"/>
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    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF15">
        <property type="entry name" value="ZINC FINGER AND BTB DOMAIN-CONTAINING PROTEIN 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18450">
        <property type="entry name" value="zf_C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="11">
        <location>
            <begin position="30"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="572"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="734"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="840"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="603"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="760"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="475"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="517"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="776"/>
            <end position="792"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
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    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000043074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="863" mass="95233" checksum="C77C5209F72CE5F9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FBW4</accession>
    <name>A0A8B7FBW4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Prenylcysteine oxidase 1</fullName>
            <ecNumber evidence="10">1.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">LOC105863272</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Only active against free prenylcysteines and not prenylcysteine residues within prenylated proteins or peptides. Involved in the final step in the degradation of prenylated proteins, by degrading prenylcysteines after the protein has been degraded.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:30231"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15894"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:62141"/>
            <dbReference type="EC" id="1.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:30232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(2E,6E,10E)-geranylgeranyl]-L-cysteine + O2 + H2O = (2E,6E,10E)-geranylgeranial + L-cysteine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:70407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:189549"/>
            <dbReference type="ChEBI" id="CHEBI:189554"/>
            <dbReference type="EC" id="1.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:70408"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an S-polyprenyl-L-cysteine + O2 + H2O = a polyprenal + L-cysteine + H2O2</text>
            <dbReference type="Rhea" id="RHEA:53892"/>
            <dbReference type="Rhea" id="RHEA-COMP:13675"/>
            <dbReference type="Rhea" id="RHEA-COMP:13676"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:137934"/>
            <dbReference type="ChEBI" id="CHEBI:137935"/>
            <dbReference type="EC" id="1.8.3.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:53893"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Lysosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the prenylcysteine oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.5" evidence="10"/>
    <dbReference type="EMBL" id="ABDC03005108">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012605648.1">
        <property type="nucleotide sequence ID" value="XM_012750194.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FBW4"/>
    <dbReference type="Ensembl" id="ENSMICT00000070842.1">
        <property type="protein sequence ID" value="ENSMICP00000042636.1"/>
        <property type="gene ID" value="ENSMICG00000045047.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105863272"/>
    <dbReference type="KEGG" id="mmur:105863272"/>
    <dbReference type="CTD" id="51449"/>
    <dbReference type="GeneTree" id="ENSGT00390000011206"/>
    <dbReference type="OrthoDB" id="437369at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001735">
        <property type="term" value="F:prenylcysteine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030327">
        <property type="term" value="P:prenylated protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030328">
        <property type="term" value="P:prenylcysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000081">
        <property type="entry name" value="prenylcysteine oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010795">
        <property type="entry name" value="Prenylcys_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017046">
        <property type="entry name" value="Prenylcysteine_Oxase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944">
        <property type="entry name" value="FARNESYLCYSTEINE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15944:SF3">
        <property type="entry name" value="PRENYLCYSTEINE OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07156">
        <property type="entry name" value="Prenylcys_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036292">
        <property type="entry name" value="Prenylcysteine_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044133563" description="Prenylcysteine oxidase 1" evidence="17">
        <location>
            <begin position="29"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Prenylcysteine lyase" evidence="18">
        <location>
            <begin position="128"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000042636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="505" mass="56252" checksum="FB4D9B0D6C02A6E5" modified="2022-01-19" version="1">MRRAVLELVSPLVGLWLLLCSWGCPGNAEPRSPPEKIAIIGAGIGGTSAAYILRQKFGKDVKIDVFEREEVGGRLATLTVQGEDYEAGGSIIHPLNLHMKRFVKDLGLSALQVSGGLVGVYDGKTLVFEESSWFIINMIKLIWRYGFQPLRMHMWVEDLLGKFMRIYRYQSHEYAFSSVEKLLHAAGGDEFLGLLNRTLLEALQKAGFSEKFLNEMIAPVMRVNYGQSTGLNAFVGAVSLSGGDSGLWAVEGGNKLVCSGLLQASKSNLISGSVVYIEEKTKTKQTGYPTTMYEVVYQIGSETRSDFYDIVLVAAPLNRKMSNITFLNFDPPIEEFHQNYEHIVTTLVKGELNASVFGSRAIDNFGLGMVLTTDNSDLFINSLGMPSSVKKKENLQPSTDGTFVWKMFSPETLTKAQILKLFLSYDYAVKKPWLAYPHYEPPEKCPSIILHDRLYYINGMECAASAMEMSAIAAYNAALLAYHRWNGHTDMIDQDGLYEKLKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FDU5</accession>
    <name>A0A8B7FDU5_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dynein axonemal assembly factor 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">DNAAF6</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIH1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03034322">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606412.1">
        <property type="nucleotide sequence ID" value="XM_012750958.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012606417.1">
        <property type="nucleotide sequence ID" value="XM_012750963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FDU5"/>
    <dbReference type="Ensembl" id="ENSMICT00000009767.3">
        <property type="protein sequence ID" value="ENSMICP00000008893.2"/>
        <property type="gene ID" value="ENSMICG00000009770.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105863623"/>
    <dbReference type="KEGG" id="mmur:105863623"/>
    <dbReference type="CTD" id="139212"/>
    <dbReference type="GeneTree" id="ENSGT00390000015219"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome X"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030317">
        <property type="term" value="P:flagellated sperm motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036159">
        <property type="term" value="P:inner dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036158">
        <property type="term" value="P:outer dynein arm assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026697">
        <property type="entry name" value="DNAAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041442">
        <property type="entry name" value="PIH1D1/2/3_CS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083:SF0">
        <property type="entry name" value="DYNEIN AXONEMAL ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21083">
        <property type="entry name" value="TWISTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18201">
        <property type="entry name" value="PIH1_CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIH1D1/2/3 CS-like" evidence="3">
        <location>
            <begin position="105"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000008893.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="209" mass="23423" checksum="2079949DA0AF6D9C" modified="2022-01-19" version="1">MDSENTEAESMRPKNLEIETLSSISTLEALSELINPEEEDDFDSGQSNYSSSVGAMGPGNIGPPQREEPKVIPQASEERGGDIWNPEEVPEGAEHDDMWDVREIPEFEIVFQQQVGTEDVFLAFTRKDPSTACCQDLVVKIKLPDTNPSDIDIDIQEMFLDLRTPNKKLLITLPHPVECSSAKASYTRETETLEVTATMKRELDVVNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7FKT6</accession>
    <name>A0A8B7FKT6_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zinc finger-containing ubiquitin peptidase 1</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Lys-63-specific deubiquitinase ZUFSP</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Zinc finger with UFM1-specific peptidase domain protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">ZUFSP</name>
        <name evidence="22" type="synonym">ZUP1</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2007-07" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="The Genome Sequencing Platform"/>
                <consortium name="The Genome Assembly Team"/>
                <person name="Lindblad-Toh K."/>
                <person name="DiPalma F."/>
                <person name="Gnerre S."/>
                <person name="Clamp M."/>
                <person name="Lander E.S."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="24" key="3">
        <citation type="submission" date="2023-09" db="UniProtKB">
            <authorList>
                <consortium name="RefSeq"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
        <source>
            <tissue evidence="24">Liver</tissue>
        </source>
    </reference>
    <reference evidence="22" key="4">
        <citation type="submission" date="2025-05" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 25">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with RPA1 and RPA2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C78 family. ZUFSP subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="ABDC03008339">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609287.1">
        <property type="nucleotide sequence ID" value="XM_012753833.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609288.1">
        <property type="nucleotide sequence ID" value="XM_012753834.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609289.1">
        <property type="nucleotide sequence ID" value="XM_012753835.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012609290.1">
        <property type="nucleotide sequence ID" value="XM_012753836.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7FKT6"/>
    <dbReference type="Ensembl" id="ENSMICT00000013669.3">
        <property type="protein sequence ID" value="ENSMICP00000012471.2"/>
        <property type="gene ID" value="ENSMICG00000013671.3"/>
    </dbReference>
    <dbReference type="Ensembl" id="ENSMICT00000066637.1">
        <property type="protein sequence ID" value="ENSMICP00000046856.1"/>
        <property type="gene ID" value="ENSMICG00000013671.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105865349"/>
    <dbReference type="KEGG" id="mmur:105865349"/>
    <dbReference type="CTD" id="221302"/>
    <dbReference type="GeneTree" id="ENSGT00390000008232"/>
    <dbReference type="OrthoDB" id="288987at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.130:FF:000002">
        <property type="entry name" value="Zinc finger containing ubiquitin peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
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        <property type="entry name" value="Znf_C2H2_type"/>
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        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR24403:SF82">
        <property type="entry name" value="ZINC FINGER-CONTAINING UBIQUITIN PEPTIDASE 1"/>
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        <property type="entry name" value="Peptidase_C78"/>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="21">
        <location>
            <begin position="194"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
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            <begin position="242"/>
            <end position="263"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010469"/>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50157"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="RefSeq" id="XP_012609287.1"/>
        </source>
    </evidence>
    <sequence length="579" mass="66332" checksum="469E6A8912BB5B40" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G166</accession>
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        <submittedName>
            <fullName evidence="12">Heat shock transcription factor 1</fullName>
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        <name evidence="12" type="primary">HSF1</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
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    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HSF family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_012760244.2"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <location>
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        </location>
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        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
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</entry>
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        <name evidence="17" type="primary">CLEC4D</name>
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        <name type="scientific">Microcebus murinus</name>
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            <taxon>Eutheria</taxon>
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    <reference evidence="17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03010436">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012616155.1">
        <property type="nucleotide sequence ID" value="XM_012760701.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G285"/>
    <dbReference type="Ensembl" id="ENSMICT00000039571.2">
        <property type="protein sequence ID" value="ENSMICP00000019441.1"/>
        <property type="gene ID" value="ENSMICG00000028843.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105869096"/>
    <dbReference type="KEGG" id="mmur:105869096"/>
    <dbReference type="CTD" id="338339"/>
    <dbReference type="GeneTree" id="ENSGT00940000162400"/>
    <dbReference type="OrthoDB" id="6133475at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034987">
        <property type="term" value="F:immunoglobulin receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038187">
        <property type="term" value="F:pattern recognition receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002250">
        <property type="term" value="P:adaptive immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061760">
        <property type="term" value="P:antifungal innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038094">
        <property type="term" value="P:Fc-gamma receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043123">
        <property type="term" value="P:positive regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030887">
        <property type="term" value="P:positive regulation of myeloid dendritic cell activation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002292">
        <property type="term" value="P:T cell differentiation involved in immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd03590">
        <property type="entry name" value="CLECT_DC-SIGN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.100.10:FF:000024">
        <property type="entry name" value="C-type lectin domain family 4 member A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="entry name" value="Mannose-Binding Protein A, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001304">
        <property type="entry name" value="C-type_lectin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050111">
        <property type="entry name" value="C-type_lectin/snaclec_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033989">
        <property type="entry name" value="CD209-like_CTLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22803">
        <property type="entry name" value="MANNOSE, PHOSPHOLIPASE, LECTIN RECEPTOR RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00059">
        <property type="entry name" value="Lectin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00034">
        <property type="entry name" value="CLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50041">
        <property type="entry name" value="C_TYPE_LECTIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1064">Adaptive immunity</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0399">Innate immunity</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="C-type lectin" evidence="16">
        <location>
            <begin position="88"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000019441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="212" mass="24543" checksum="D2A5DDDC2404DA14" modified="2022-01-19" version="1">MGLEESQSKEGGEHSQRVPWIIAVVLIALLSACFIANCLVTHHSFLRCKGDMGMHKLPEYHTKLTCVRQTSELKGSTWNCCPVLWRAFQSSCFLPLNDNKTWAESERNCSGMGAHLATISTEAEQNFVIQFLDRQFSYFLGLTDENTEGQWRWVDQTPFNMHMVFWHKGEPNNYKEENCVVLLYTKDKWAWNNIPCNLERYRICKIPAMALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G5B6</accession>
    <name>A0A8B7G5B6_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SWI/SNF related BAF chromatin remodeling complex subunit D1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SMARCD1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMARCD family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03009633">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012617417.1">
        <property type="nucleotide sequence ID" value="XM_012761963.3"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G5B6"/>
    <dbReference type="Ensembl" id="ENSMICT00000044310.2">
        <property type="protein sequence ID" value="ENSMICP00000039064.1"/>
        <property type="gene ID" value="ENSMICG00000015651.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105869838"/>
    <dbReference type="KEGG" id="mmur:105869838"/>
    <dbReference type="CTD" id="6602"/>
    <dbReference type="GeneTree" id="ENSGT00940000156629"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071565">
        <property type="term" value="C:nBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071564">
        <property type="term" value="C:npBAF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd17674">
        <property type="entry name" value="SWIB_BAF60A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.245.10:FF:000001">
        <property type="entry name" value="SWI/SNF-related matrix-associated regulator of chromatin subfamily D member 3 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038041">
        <property type="entry name" value="SMARCD1_SWIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="4">
        <location>
            <begin position="290"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000039064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="515" mass="58247" checksum="D683AA1E345C7369" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G5T9</accession>
    <name>A0A8B7G5T9_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">UQCRQ</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03022404">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012617612.1">
        <property type="nucleotide sequence ID" value="XM_012762158.1"/>
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    <dbReference type="AlphaFoldDB" id="A0A8B7G5T9"/>
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        <property type="protein sequence ID" value="ENSMICP00000048701.1"/>
        <property type="gene ID" value="ENSMICG00000041653.1"/>
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    <dbReference type="GeneID" id="105869963"/>
    <dbReference type="KEGG" id="mmur:105869963"/>
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        <property type="component" value="Chromosome 19"/>
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        <property type="term" value="C:mitochondrial inner membrane"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="P:cerebellar Purkinje cell layer development"/>
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        <property type="term" value="P:hippocampus development"/>
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        <property type="term" value="P:hypothalamus development"/>
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        <property type="term" value="P:midbrain development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
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        <property type="term" value="P:pons development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0021860">
        <property type="term" value="P:pyramidal neuron development"/>
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    </dbReference>
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        <property type="term" value="P:subthalamus development"/>
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        <property type="term" value="P:thalamus development"/>
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        <property type="project" value="Ensembl"/>
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        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000048701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="82" mass="9678" checksum="019E469F334B8BC9" modified="2022-01-19" version="1">MGREFGNLTRMRHVITYSLSPFEQRAFPNYFSKGVPNVLRRIQASALRVAPPFVVFYLVYTWGMEEFEKSKRKNPAVYENDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7G8F1</accession>
    <name>A0A8B7G8F1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fibronectin type III and SPRY domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">FSD2</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="9">Interacts with CMYA5. In cardiac muscles, identified in a complex composed of FSD2, CMYA5 and RYR2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Sarcoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ABDC03013891">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012618679.1">
        <property type="nucleotide sequence ID" value="XM_012763225.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7G8F1"/>
    <dbReference type="Ensembl" id="ENSMICT00000030403.2">
        <property type="protein sequence ID" value="ENSMICP00000032063.1"/>
        <property type="gene ID" value="ENSMICG00000017199.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105870571"/>
    <dbReference type="KEGG" id="mmur:105870571"/>
    <dbReference type="CTD" id="123722"/>
    <dbReference type="GeneTree" id="ENSGT00940000158441"/>
    <dbReference type="OrthoDB" id="6232067at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016529">
        <property type="term" value="C:sarcoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000051">
        <property type="entry name" value="Fibronectin type III and SPRY domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001757">
        <property type="entry name" value="Fibronectin type III and SPRY domain containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003879">
        <property type="entry name" value="Butyrophylin_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050617">
        <property type="entry name" value="E3_ligase_FN3/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24099:SF6">
        <property type="entry name" value="FIBRONECTIN TYPE III AND SPRY DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01407">
        <property type="entry name" value="BUTYPHLNCDUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="376"/>
            <end position="471"/>
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        <location>
            <begin position="472"/>
            <end position="565"/>
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            <begin position="547"/>
            <end position="746"/>
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            <begin position="42"/>
            <end position="64"/>
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            <end position="288"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GF68</accession>
    <name>A0A8B7GF68_MICMU</name>
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        <recommendedName>
            <fullName evidence="6">Ankyrin repeat domain-containing protein 1</fullName>
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        <alternativeName>
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        <name evidence="9" type="primary">ANKRD1</name>
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        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
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            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
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        </citation>
        <scope>IDENTIFICATION</scope>
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        <citation type="submission" date="2025-09" db="UniProtKB">
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                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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        <property type="component" value="Chromosome 15"/>
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        <property type="project" value="Ensembl"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="152"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="251"/>
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        </location>
    </feature>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023043"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039564"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00078011"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="319" mass="36340" checksum="9230558A7C2AD6B8" modified="2022-01-19" version="1">MMMLKVEELVTGKKNSNGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLPAHPLTLGEQQWEKEKQREAELKKKKLEQRSKLENLEDLEIIIQLKKRKKYKKTKVPVMKEPEPEIITEPVDVPRFLKAALENKLPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLIEAGAQIEFRDMLESTAIHWASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDREGDTPLHDAVRLNRYRMIRLLITYGSDLNVKNCAGKTPMDLVLHWQNGTKAIFDSLKESSYKTSRIATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GFY4</accession>
    <name>A0A8B7GFY4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">GAR1</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03030219">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621656.1">
        <property type="nucleotide sequence ID" value="XM_012766202.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621657.1">
        <property type="nucleotide sequence ID" value="XM_012766203.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621658.1">
        <property type="nucleotide sequence ID" value="XM_012766204.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GFY4"/>
    <dbReference type="Ensembl" id="ENSMICT00000003323.3">
        <property type="protein sequence ID" value="ENSMICP00000003020.3"/>
        <property type="gene ID" value="ENSMICG00000003326.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105872310"/>
    <dbReference type="CTD" id="54433"/>
    <dbReference type="GeneTree" id="ENSGT00730000111223"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 28"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090661">
        <property type="term" value="C:box H/ACA telomerase RNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001650">
        <property type="term" value="C:fibrillar center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="168"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000003020.3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="217" mass="22432" checksum="EB3F858E63B13CB9" modified="2022-01-19" version="1">MSFRGGGRGGFSRGGGGGGFNRGGGGTNNHFRGGGGGNFRGGGGRGGFGRGGGRGAFNKGQDQGPPERVVLLGEFLHPCEDDIVCKCTTDENKVPYFNAPVYLENKEQIGKVDEIFGQLRDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKAPPRGGGRGGGRGGGRGGVGRGGGRGGGFRGGRGGGGGFRGGRGGGGFRGRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GGD1</accession>
    <name>A0A8B7GGD1_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Gasdermin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">GSDMA</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gasdermin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03020145">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012621524.1">
        <property type="nucleotide sequence ID" value="XM_012766070.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GGD1"/>
    <dbReference type="Ensembl" id="ENSMICT00000064551.1">
        <property type="protein sequence ID" value="ENSMICP00000050159.1"/>
        <property type="gene ID" value="ENSMICG00000047508.1"/>
    </dbReference>
    <dbReference type="GeneID" id="105872220"/>
    <dbReference type="KEGG" id="mmur:105872220"/>
    <dbReference type="CTD" id="284110"/>
    <dbReference type="GeneTree" id="ENSGT00950000183140"/>
    <dbReference type="OrthoDB" id="9944616at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 16"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022829">
        <property type="term" value="F:wide pore channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012501">
        <property type="term" value="P:programmed cell death"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070269">
        <property type="term" value="P:pyroptotic inflammatory response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007677">
        <property type="entry name" value="Gasdermin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040460">
        <property type="entry name" value="Gasdermin_pore"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041263">
        <property type="entry name" value="Gasdermin_PUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16399">
        <property type="entry name" value="GASDERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16399:SF18">
        <property type="entry name" value="GASDERMIN-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04598">
        <property type="entry name" value="Gasdermin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17708">
        <property type="entry name" value="Gasdermin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1210">Necrosis</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Gasdermin pore forming" evidence="13">
        <location>
            <begin position="3"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Gasdermin PUB" evidence="14">
        <location>
            <begin position="258"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="258"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000050159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="446" mass="49631" checksum="FBF1354D2E293074" modified="2022-01-19" version="1">MTMFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLDVLEPGSSPSDPTDAGSFGFKNMLDARVEGEVDVPKTVKVTGTAGLSRNSTLEVQTLSVAPKALETLQGERKLVADHPFLKEMRDRGENLYVVMEVVETVQEVTLERAGKAEGCFSLPFFAPLGLQGSVNHKEAVTIPKGCVLAFRVRQLMVKGKDEWDIPHICNDNMQTFPPGEKPGEEKFIFIQASDVGDVHEGFKTLKEEVQRETQEVDKLSRMGQSSLLSSLSKLLGKKKELQDLELELEGALDKGHEVALEALPKDVLLSKEAMGAILYFLGALTELSEAQQKLLVKSMEKKILPVQLKLVESTMEQNFLQDKESVFPLQPELLSPLGEEELTLTEALVGLSGLEVQRSGPQYTWDPDTLPRLCALYASLSLLQLLTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GKE4</accession>
    <name>A0A8B7GKE4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">60S ribosomal protein L36a-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">LOC105873222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03015166">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012623432.1">
        <property type="nucleotide sequence ID" value="XM_012767978.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GKE4"/>
    <dbReference type="Ensembl" id="ENSMICT00000045162.2">
        <property type="protein sequence ID" value="ENSMICP00000032177.1"/>
        <property type="gene ID" value="ENSMICG00000032066.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105873222"/>
    <dbReference type="KEGG" id="mmur:105873222"/>
    <dbReference type="GeneTree" id="ENSGT00390000018085"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000032177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="12168" checksum="ADD7BBF51D2697B0" modified="2022-01-19" version="1">MVNVPKTRRTFCKKCGKHQPHKVTQYKKGKDSLYAQGKRRYDRKQSGYGGQTKPIFRKKAKTTKKIVLRLECVEPNCRSKRMLAIKRCKHFELGGDKKRKAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GRG3</accession>
    <name>A0A8B7GRG3_MICMU</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T cell activation inhibitor, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">TCAIM</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <dbReference type="EMBL" id="ABDC03018122">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625838.1">
        <property type="nucleotide sequence ID" value="XM_012770384.2"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625839.1">
        <property type="nucleotide sequence ID" value="XM_012770385.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012625840.1">
        <property type="nucleotide sequence ID" value="XM_012770386.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GRG3"/>
    <dbReference type="Ensembl" id="ENSMICT00000059035.1">
        <property type="protein sequence ID" value="ENSMICP00000040905.1"/>
        <property type="gene ID" value="ENSMICG00000038369.2"/>
    </dbReference>
    <dbReference type="GeneID" id="105874476"/>
    <dbReference type="KEGG" id="mmur:105874476"/>
    <dbReference type="CTD" id="285343"/>
    <dbReference type="GeneTree" id="ENSGT00390000012832"/>
    <dbReference type="OrthoDB" id="4238at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028031">
        <property type="entry name" value="DUF4460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027989">
        <property type="entry name" value="DUF4461"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027986">
        <property type="entry name" value="TCAIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31596:SF1">
        <property type="entry name" value="T-CELL ACTIVATION INHIBITOR, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14687">
        <property type="entry name" value="DUF4460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14688">
        <property type="entry name" value="DUF4461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4460" evidence="1">
        <location>
            <begin position="24"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4461" evidence="2">
        <location>
            <begin position="188"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000040905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="496" mass="57768" checksum="8C2F4641D104ED43" modified="2022-01-19" version="1">MFCHLRPVRRLCLEKIFSPWFVYSRALSAAEAVNALRPFYFAVHPDFFGQHPKEREINENSLKRLSVYLENLQKPGFKSLKPTQLMFYVRGTDQNSSDGHEPFSTSGFRAVKFTLHTRDLLSTVLYILNSCSLSIEHIQSSNTNVHSQPLKEAKRMSDRPIKWDKSYYSFTGFRDPDEDLEQVSRMETTLTSWLDNNGKSAVKKLKHSLPLRKELDRLKDELSHQLQLSDIRWQRSWGIAHRCSQLHSLGRLAQQNLETLKKAKGCTVLFTDRSGVSAVGHVMLGTMDVHHHWVKLFERLPSYFDLQRKLMLLEDQISYLLGGIQVVYIDELQPVLTLEEYYSLLDVFYNRILESRMPFHPQSLRGLQMILNSDRYAPSLHELGHFNIPVLCDLANLQWFILTKAQQARENMKRKEELKVIENELIQASTKKFSLEKLYKEPSISSIQMVDCCKRLLEQSLPYLHGMHLCVSHFYSVMQDGDLCIPWNWKNGEAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GTK4</accession>
    <name>A0A8B7GTK4_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b-c1 complex subunit 1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex III subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Core protein I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Ubiquinol-cytochrome-c reductase complex core protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">UQCRC1</name>
        <name evidence="19" type="synonym">LOC105874931</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="12">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with UQCC6. Interacts with STMP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03018185">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012626642.1">
        <property type="nucleotide sequence ID" value="XM_012771188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GTK4"/>
    <dbReference type="Ensembl" id="ENSMICT00000014345.3">
        <property type="protein sequence ID" value="ENSMICP00000013076.2"/>
        <property type="gene ID" value="ENSMICG00000014344.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105874931"/>
    <dbReference type="KEGG" id="mmur:105874931"/>
    <dbReference type="GeneTree" id="ENSGT00940000158931"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 14"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000016">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF116">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="17">
        <location>
            <begin position="58"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="18">
        <location>
            <begin position="210"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000013076.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="480" mass="52728" checksum="1FF9F68616324887" modified="2022-01-19" version="1">MAASVVSRVASAGAQVLLHTRRSPALLRAPAFRSTATFAQALQLVPETQVSLLDNGLRVASEQSSQPTCTVGVWIDAGSRYETEKNNGAGYFVEHLAFKGTKNLPGNALEKEVESIGAHLNAYSTREHTAYYVKALSKDLPKVVELLADIVQNCSLEDSQIEKERDVILQEMQENDASMRDVVFDYLHATAFQGTPLAQAVEGPSENVRKLSRADLTEYLDRHYKAPRMVLAAAGGVEHQQLLGLAQKHFSSISRTYAEDAVPTLSPCRFTGSEIRHRDDALPLAHVAIAVEGPGWANPDNVALQVANAIIGHYDCTYGGGVHLSSPLASVAAAKKLCQSFQTFNICYAETGLLGAHFVCDRMSIDDMMFFLQGQWMRLCTSATEGEVERGKNILRNALISHLDGTTPVCEDIGRSLLTYGRRIPLAEWESRIAVVDASMVREVCSRYFYDQCPAVAGLGPIEQLPDYNRIRSGMFWLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GV06</accession>
    <name>A0A8B7GV06_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosducin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">PDCL</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="10">Forms a complex with the beta and gamma subunits of the GTP-binding protein, transducin. Interacts with the CCT chaperonin complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03014859">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627262.1">
        <property type="nucleotide sequence ID" value="XM_012771808.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627263.1">
        <property type="nucleotide sequence ID" value="XM_012771809.3"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627264.1">
        <property type="nucleotide sequence ID" value="XM_012771810.2"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GV06"/>
    <dbReference type="Ensembl" id="ENSMICT00000003223.3">
        <property type="protein sequence ID" value="ENSMICP00000002924.1"/>
        <property type="gene ID" value="ENSMICG00000003224.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875159"/>
    <dbReference type="KEGG" id="mmur:105875159"/>
    <dbReference type="CTD" id="5082"/>
    <dbReference type="GeneTree" id="ENSGT00940000159569"/>
    <dbReference type="OMA" id="GIIEMMP"/>
    <dbReference type="OrthoDB" id="70588at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030030">
        <property type="term" value="P:cell projection organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902605">
        <property type="term" value="P:heterotrimeric G-protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045880">
        <property type="term" value="P:positive regulation of smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008277">
        <property type="term" value="P:regulation of G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007601">
        <property type="term" value="P:visual perception"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02987">
        <property type="entry name" value="Phd_like_Phd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000072">
        <property type="entry name" value="Phosducin like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.10:FF:000001">
        <property type="entry name" value="phosducin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.10">
        <property type="entry name" value="Phosducin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001200">
        <property type="entry name" value="Phosducin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051499">
        <property type="entry name" value="Phosducin-like_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023196">
        <property type="entry name" value="Phosducin_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46052:SF4">
        <property type="entry name" value="PHOSDUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00677">
        <property type="entry name" value="PHOSDUCIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="9" id="KW-0844">Vision</keyword>
    <feature type="domain" description="Phosducin" evidence="13">
        <location>
            <begin position="36"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00063912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000002924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="301" mass="34408" checksum="F4C94A616C1A436B" modified="2022-01-19" version="1">MTTLDDKLLGEKLQYYYSSSEDEDSDHEDKDRGRGAPASSSMHAEAELAGEGISVNTGPKGVINDWRRFKQLETEQREEQCREMERLIKKLSMTCRSHLDEEEEQQKQKDLQEKISGKMTLKEFAMMNEDQDDEEFLQQYRKQRMEEMRQQLHKGPQFKQVFEIPSGEGFLDMIDKEQKSTLIMVHIYEDGIPGTEAMNGCMICLAAEYPAVKFCRVKSSVIGASSRFTRNALPALLIYKGGELIGNFVRVTDQLGEDFFAVDLEAFLQEFGLLPEKEVLVLTSVRNSATCHSEDSDLEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7GWC0</accession>
    <name>A0A8B7GWC0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding protein RO60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">60 kDa SS-A/Ro ribonucleoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">TROVE domain family member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">RO60</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RAB11FIP5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ro 60 kDa family.</text>
    </comment>
    <dbReference type="EMBL" id="ABDC03029654">
        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627853.1">
        <property type="nucleotide sequence ID" value="XM_012772399.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_012627854.1">
        <property type="nucleotide sequence ID" value="XM_012772400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A8B7GWC0"/>
    <dbReference type="Ensembl" id="ENSMICT00000041956.2">
        <property type="protein sequence ID" value="ENSMICP00000021462.2"/>
        <property type="gene ID" value="ENSMICG00000011506.3"/>
    </dbReference>
    <dbReference type="GeneID" id="105875396"/>
    <dbReference type="KEGG" id="mmur:105875396"/>
    <dbReference type="CTD" id="6738"/>
    <dbReference type="GeneTree" id="ENSGT00390000006200"/>
    <dbReference type="OrthoDB" id="6098064at2759"/>
    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 27"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035457">
        <property type="term" value="P:cellular response to interferon-alpha"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060271">
        <property type="term" value="P:cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002520">
        <property type="term" value="P:immune system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007224">
        <property type="term" value="P:smoothened signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000033">
        <property type="entry name" value="60 kDa SS-A/Ro ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000040">
        <property type="entry name" value="60 kDa SS-A/Ro ribonucleoprotein isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040322">
        <property type="entry name" value="TROVE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008858">
        <property type="entry name" value="TROVE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037214">
        <property type="entry name" value="TROVE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056800">
        <property type="entry name" value="vWA_Ro60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202">
        <property type="entry name" value="60 KDA RIBONUCLEOPROTEIN SSA/RO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14202:SF0">
        <property type="entry name" value="RNA-BINDING PROTEIN RO60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05731">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25045">
        <property type="entry name" value="vWA_Ro60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140864">
        <property type="entry name" value="TROVE domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50988">
        <property type="entry name" value="TROVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0970">Cilium biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="TROVE" evidence="12">
        <location>
            <begin position="16"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000021462.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
        </source>
    </evidence>
    <sequence length="538" mass="60615" checksum="248C9DB317DF37D9" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H3S1</accession>
    <name>A0A8B7H3S1_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Delta-like protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Drosophila Delta homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">DLL3</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference evidence="22" key="3">
        <citation type="submission" date="2025-09" db="UniProtKB">
            <authorList>
                <consortium name="Ensembl"/>
            </authorList>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Can bind and activate Notch-1 or another Notch receptor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="status" value="NOT_ANNOTATED_CDS"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_012630076.1">
        <property type="nucleotide sequence ID" value="XM_012774622.2"/>
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        <property type="protein sequence ID" value="ENSMICP00000010439.3"/>
        <property type="gene ID" value="ENSMICG00000011466.3"/>
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    <dbReference type="GeneID" id="105876785"/>
    <dbReference type="KEGG" id="mmur:105876785"/>
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    <dbReference type="GeneTree" id="ENSGT00940000162127"/>
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    <dbReference type="Proteomes" id="UP000694394">
        <property type="component" value="Chromosome 22"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0007386">
        <property type="term" value="P:compartment pattern specification"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045197">
        <property type="term" value="P:establishment or maintenance of epithelial cell apical/basal polarity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007157">
        <property type="term" value="P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050768">
        <property type="term" value="P:negative regulation of neurogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048339">
        <property type="term" value="P:paraxial mesoderm development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001501">
        <property type="term" value="P:skeletal system development"/>
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        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001756">
        <property type="term" value="P:somitogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="Ensembl"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000368">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000403">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
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        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000585">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
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    <dbReference type="FunFam" id="2.60.40.3510:FF:000005">
        <property type="entry name" value="Delta-like 3 (Drosophila), isoform CRA_b"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="2.10.25.10:FF:000347">
        <property type="entry name" value="delta-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000066">
        <property type="entry name" value="FAT atypical cadherin 4"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="EGF"/>
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        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
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    <dbReference type="InterPro" id="IPR013032">
        <property type="entry name" value="EGF-like_CS"/>
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    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
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        <property type="entry name" value="Notch_Cell-Fate_Det"/>
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        <property type="entry name" value="Notch_ligand_N"/>
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        <property type="entry name" value="CRUMBS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DROSOPHILA CRUMBS HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="EGF_DL_JAG"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="MNNL"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGFBLOOD"/>
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    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
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    <keyword evidence="3 17" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="11 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0914">Notch signaling pathway</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 20" id="KW-0732">Signal</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044134022" description="Delta-like protein 3" evidence="20">
        <location>
            <begin position="27"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="274"/>
            <end position="310"/>
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    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="312"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="353"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="391"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="21">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="548"/>
            <end position="572"/>
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    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="300"/>
            <end position="309"/>
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    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="341"/>
            <end position="350"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="417"/>
            <end position="426"/>
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    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
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    </evidence>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00055837"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062208"/>
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    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071912"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00080954"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
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    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Ensembl" id="ENSMICP00000010439.3"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000694394"/>
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    </evidence>
    <sequence length="590" mass="61290" checksum="E9940419EF90DC4C" modified="2022-01-19" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2022-01-19" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A8B7H7P0</accession>
    <name>A0A8B7H7P0_MICMU</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma</fullName>
            <ecNumber evidence="14">2.7.1.149</ecNumber>
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        <alternativeName>
            <fullName evidence="16">Phosphatidylinositol 5-phosphate 4-kinase type II gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="primary">PIP4K2C</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Microcebus murinus</name>
        <name type="common">Gray mouse lemur</name>
        <name type="synonym">Lemur murinus</name>
        <dbReference type="NCBI Taxonomy" id="30608"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Metazoa</taxon>
            <taxon>Chordata</taxon>
            <taxon>Craniata</taxon>
            <taxon>Vertebrata</taxon>
            <taxon>Euteleostomi</taxon>
            <taxon>Mammalia</taxon>
            <taxon>Eutheria</taxon>
            <taxon>Euarchontoglires</taxon>
            <taxon>Primates</taxon>
            <taxon>Strepsirrhini</taxon>
            <taxon>Lemuriformes</taxon>
            <taxon>Cheirogaleidae</taxon>
            <taxon>Microcebus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>Mouse lemur reference genome and diversity panel.</title>
            <authorList>
                <person name="Harris R."/>
                <person name="Larsen P."/>
                <person name="Liu Y."/>
                <person name="Hughes D.S."/>
                <person name="Murali S."/>
                <person name="Raveendran M."/>
                <person name="Korchina V."/>
                <person name="Wang M."/>
                <person name="Jhangiani S."/>
                <person name="Bandaranaike D."/>
                <person name="Bellair M."/>
                <person name="Blankenburg K."/>
                <person name="Chao H."/>
                <person name="Dahdouli M."/>
                <person name="Dinh H."/>
                <person name="Doddapaneni H."/>
                <person name="English A."/>
                <person name="Firestine M."/>
                <person name="Gnanaolivu R."/>
                <person name="Gross S."/>
                <person name="Hernandez B."/>
                <person name="Javaid M."/>
                <person name="Jayaseelan J."/>
                <person name="Jones J."/>
                <person name="Khan Z."/>
                <person name="Kovar C."/>
                <person name="Kurapati P."/>
                <person name="Le B."/>
                <person name="Lee S."/>
                <person name="Li M."/>
                <person name="Mathew T."/>
                <person name="Narasimhan A."/>
                <person name="Ngo D."/>
                <person name="Nguyen L."/>
                <person name="Okwuonu G."/>
                <person name="Ongeri F."/>
                <person name="Osuji N."/>
                <person name="Pu L.-L."/>
                <person name="Puazo M."/>
                <person name="Quiroz J."/>
                <person name="Raj R."/>
                <person name="Rajbhandari K."/>
                <person name="Reid J.G."/>
                <person name="Santibanez J."/>
                <person name="Sexton D."/>
                <person name="Skinner E."/>
                <person name="Vee V."/>
                <person name="Weissenberger G."/>
                <person name="Wu Y."/>
                <person name="Xin Y."/>
                <person name="Han Y."/>
                <person name="Campbell C."/>
                <person name="Brown A."/>
                <person name="Sullivan B."/>
                <person name="Shelton J."/>
                <person name="Brown S."/>
                <person name="Dudchenko O."/>
                <person name="Machol I."/>
                <person name="Durand N."/>
                <person name="Shamim M."/>
                <person name="Lieberman A."/>
                <person name="Muzny D.M."/>
                <person name="Richards S."/>
                <person name="Yoder A."/>
                <person name="Worley K.C."/>
                <person name="Rogers J."/>
                <person name="Gibbs R.A."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2025-08" db="UniProtKB">
            <authorList>
                <consortium name="Ens